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5148results about "Mixing methods" patented technology

Device and method for creating hydrodynamic cavitation in fluids

This invention provides a device and method for creating hydrodynamic cavitation in fluids which includes a flow-through chamber intermediate an inlet opening and an outlet opening; the flow-through chamber having an upstream opening portion communicating with the inlet opening and a downstream opening portion communicating with the outlet opening; the cross-sectional area of the downstream opening portion being greater than the cross-sectional area of the upstream opening portion; and a cavitation generator located within the flow-through chamber for generating a hydrodynamic cavitation field downstream from the generator. This invention also provides for a device for creating hydrodynamic cavitation in fluids wherein the walls of the flow-through chamber are removable mounted within the device and are interchangeable and replaceable with replacement walls having various shapes and configurations, thereby enabling the flow-through chamber to assume various shapes and configurations to affect cavitation. This invention also provides for a device for a device for creating hydrodynamic cavitation in fluids wherein the baffle elements are removably mounted within the device and are interchangeable and replaceable with replacement baffles having various shapes and configurations thereby enabling variable effects on cavitation.
Owner:ARISDYNE STSTEMS INC

Solid lipid particles, particles of bioactive agents and methods for the manufacture and use thereof

InactiveUS6207178B1Suppresses decrease in specific surface areaImprove bioavailabilityBiocideCosmetic preparationsLipid formationLipid particle
The present invention is in the area of administration forms and delivery systems for drugs, vaccines and other biologically active agents. More specifically the invention is related to the preparation of suspensions of colloidal solid lipid particles (SLPs) of predominantly anisometrical shape with the lipid matrix being in a stable polymorphic modification and of suspensions of micron and submicron particles of bioactive agents (PBAs); as well as to the use of such suspensions or the lyophilizates thereof as delivery systems primarily for the parenteral administration of preferably poorly water-soluble bioactive substances, particularly drugs, and to their use in cosmetic, food and agricultural products. SLPs and PBAs are prepared by the following emulsification process: (1) A solid lipid or bioactive agent or a mixture of solid lipids or bioactive agents is melted. (2) Stabilizers are added either to the lipid or bioactive agent and to the aqueous phase or to the aqueous phase only depending on their physicochemical characteristics. Stabilizers may also be added or exchanged after homogenization. (3) Drugs or other bioactive substances to be incorporated into the SLPs may be melted together with the lipids if the physicochemical characteristics of the substance permit or may be dissolved, solubilized or dispersed in the lipid melt before homogenization. (4) The aqueous phase is heated to the temperature of the melt before mixing and may contain for example stabilizers, isotonicity agents, buffering substances, cryoprotectants and/or preservatives. (5) The molten lipid compounds and the bioactive agents are emulsified in an aqueous phase preferably by high-pressure homogenization.
Owner:PHARMACIA AB
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