5964 results about "Microemulsion" patented technology

Composition for pharmaceutical or cosmetic use, capable of forming a microemulsion, comprising at least: an active principle, a lipophilic phase consisting of a mixture of fatty acid esters and glycerides, a surfactant (SA), a cosurfactant (CoSA), a hydrophilic phase, characterized: in that the lipophilic phase consists of a mixture of C8 to C18 polyglycolized glycerides having a hydrophilic-lipophilic balance (HLB) of less than 16, this lipophilic phase representing from 30 to 75% of the total weight of the composition; in that the surfactant (SA) is chosen from the group comprising saturated C8-C10 olyglycolized glycerides and oleic esters of polyglycerol, this surfactant having an HLB of less than 16; in that the cosurfactant (CoSA) is chosen from the group comprising lauric esters of propylene glycol, oleic esters of polyglycerol and ethyl diglycol; in that the SA / CoSA ratio is between 0.5 and 6; and in that the hydrophilic phase of the final microemulsion is supplied after ingestion by the physiological fluid of the digestive milieu.

The present invention generally relates to a vehicle useful for delivering a pharmaceutically active compound including a genetic molecule or composition. More particularly, the present invention provides microemulsions for transdermal delivery of pharmaceutically active agents to a subject.

There is provided a process for the preparation of an oil in water (O / W) microemulsion or sub-micron emulsion composition for dermal delivery of at least one pharmaceutically active ingredient, the method including the steps of a) Admixing a first part including at least one of the group consisting of animal, mineral or vegetable oils, silanes, siloxanes, esters, fatty acids, fats, halogen compounds or alkoxylated alcohols; and one or more lipophilic surfactants, and a second part including water and at least one hydrophilic surfactant to achieve homogeneity, b) heating the mix of step a) to a phase assembly temperature in the range of 40-99° C., preferably 45-95° C., more preferably 65-85° C. with continuous mixing to obtain a microemulsion or sub-micron emulsion, c) allowing said microemulsion or sub-micron emulsion to cool, and d) adding a third part to said microemulsion or sub-micron emulsion at a temperature between 2° C. and said phase assembly temperature, said third part if necessary being premixed and heated until the components are dissolved and including at least one component selected from the group consisting of non-surfactant amphiphilic type compound, surfactant and water with the proviso that when the third part includes water it also includes a non-surfactant amphiphilic type compound and / or surfactant. The phase assembly temperature can be determined visually by the achievement of translucence in the composition or by measures such as conductivity which peaks and then is maintained at a plateau whilst phase assembly occurs. It has been found that whilst if a non-surfactant amphiphilic type compound such as the polyol is added together with the second part as would conventionally be the case, a microemulsion or sub-micron emulsion is not formed, by adding the so called third part, phase assembly occurs at a lower temperature than would be expected and moreover, this phase appears to assist in maintaining the microemulsion or sub-micron emulsion characteristics of the formulation during storage at normal temperatures.

This invention relates to polymeric nanoparticles useful for drug delivery with target molecules bonded to the surface of the particles and having sizes of up to 1000 nm, preferably 1 nm to 400 nm, more preferably 1 nm to 200 nm, that are dispersed homogeneously in aqueous solution. The target drug / target substance is covalently bonded to the novel polymeric nanoparticles to secure them from outer intervention in vivo or cell culture in vitro until they are exposed at the target site within the cell. This invention also relates to microemulsion polymerization techniques useful for preparing the novel nanoparticles.

A method for making oil free polysiloxane standard, fine and microemulsions using emulsion polymerization is disclosed. The method comprises reacting a cyclicsiloxane in the presence of a catalyst, ionic surfactant and nonionic surfactant within a certain operating window. Emulsions containing silicone copolymers can also be produced using the method of the instant invention.

A pharmaceutical composition comprising a cyclosporin solid-state microemulsion is disclosed. In a preferred embodiment, the composition comprises a cyclosporin microemulsion dispersed in an enteric carrier. The composition does not dissolve in external phases such as artificial gastric fluid, but dissolves rapidly in artificial intestinal fluid, whereby it releases the cyclosporin microemulsion, providing rapid delivery of cyclosporin. The composition effectively maintains a therapeutic blood concentration of cyclosporin with once a day dosing, providing for convenience of administration and avoiding adverse effects induced by increasing peak blood cyclosporin concentrations associated with conventional cyclosporin formulations.

A well treatment microemulsion for use in a subterranean formation is disclosed, the microemulsion comprises a solvent blend comprising a solvent and a co-solvent; a surfactant blend comprising a surfactant, wherein the surfactant blend is able to give formation intermediate wettability properties; an alcohol; and a carrier fluid; wherein the alcohol, the solvent and surfactant blends are combined with the carrier fluid to produce the well treatment microemulsion. By intermediate wettability it is meant that the water has an advancing contact angle on the surface between 62 and 133 degrees. The associate method of treating a subterranean formation of a well with the microemulsion and the associate method of modifying the wettability of the formation with the microemulsion are also disclosed.

A microemulsion system is disclosed which comprises a solvent subsystem, a co-solvent subsystem and a surfactant subsystem comprises at least one monoalkyl branched propoxy sulfate anionic surfactant, where the microemulsion system are useful in drilling, producing, remediation, and fracturing application to reduce water blocks and water blocking in formation of a producing formation.

If the particle size of pigments in ink-jet inks is reduced below 500 nm, then the ink compositions achieved extraordinary stability; that is, there is no visible sediment formed after three weeks at ambient temperature and there is no sediment formed after heating to 70 DEG C. for 10 min followed by cooling to 0 DEG C. for 10 min. No dispersant is necessary, and the pigment particles having such a defined size may be incorporated into microemulsions, using a suitable oil (water-immiscible organic compound), at least one amphiphile, and water.

An aqueous shampoo composition comprising, in addition to water:i) at least one cleansing surfactant;ii) a cationic deposition polymer, andiii) a silicone component consisting of a blend of:(a) emulsified particles of an insoluble silicone, in which the emulsified particles of insoluble silicone are incorporated into the shampoo composition as a preformed aqueous emulsion having an average silicone particle size in the emulsion and in the shampoo composition of from 0.15 to 30 microns, and(b) microemulsified particles of an insoluble silicone, in which the microemulsified particles of insoluble silicone are incorporated into the shampoo composition as a preformed aqueous microemulsion having an average-silicone particle size in the microemulsion and in the shampoo composition of less than 0.10 microns.

The invention discloses a microemulsion metal cutting fluid which contains 1-20 wt% of fatty oil, 1-40 wt% of emulsifier, 5-40 wt% of co-emulsion, 5-30 wt% of wear and rust inhibitor, 1-20 wt% of penetrant, 5-30 wt% of pH regulator, 0.5-5 wt% of defoaming agent and 0.1-5 wt% anticorrosive bactericide. The microemulsion metal cutting fluid has excellent lubricating, antiwear, antirust, cleaning and cooling properties, and can be widely used in precise cutting work of ferrous metals and nonferrous metals.

A method of treating a well consists of introducing into the wellbore a biodegradable fluid system containing a blend of lactic acid ester, such as ethyl lactate, and a fatty acid ester, such as methyl soyate. The fluid system may be further in the form of a microemulsion that is formed by combining a blend with one or more emulsifiers, an alcohol, and water. The fluid system may be used in displacement, well remediation and stimulation as well as additional, alternative applications such as the cleaning of surface and / or downhole equipment.

The present invention provides a method for the synthesis of unagglomerated, highly dispersed, stable core / shell nanocomposite particles comprised of preparing a reverse micelle microemulsion that contains nanocomposite particles, treating the microemulsion with a silane coupling agent, breaking the microemulsion to form a suspension of the nanocomposite particles by adding an acid / alcohol solution to the microemulsion that maintains the suspension of nanocomposite particles at a pH of between about 6 and 7, and simultaneously washing and dispersing the suspension of nanocomposite particles, preferably with a size exclusion HPLC system modified to ensure unagglomeration of the nanocomposite particles. The primary particle size of the nanocomposite particles can range in diameter from between about 1 to 100 nm, preferably from between about 10 to 50 nm, more preferably about 10 to 20 nm, and most preferably about 20 nm.

A microemulsion system is disclosed which comprises a solvent subsystem, a co-solvent subsystem and a surfactant subsystem comprises at least one monoalkyl branched propoxy sulfate anionic surfactant, where the microemulsion system are useful in drilling, producing, remediation, and fracturing application to reduce water blocks and water blocking in formation of a producing formation.

The present invention relates to biocompatible microemulsion systems designed for controlled release drug delivery applications formulated with phospholipids such as lecithin (surfactant), a lipophilic additive (linker) containing 9 or more carbons in their alkyl group and hydrophilic-lipophilic balance (HLB) of 5 or less, and a surfactant-like hydrophilic additive (linker) containing between 6 to 9 carbon atoms in their alkyl tail. The combination of linkers and phospholipids produce formulations capable of delivering high concentrations of poorly soluble drugs into epithelial tissue using low surfactant concentrations, with minimum cytotoxic side effects.

The invention relates to a microemulsion-type fracture acidizing cleanup additive, and a preparation method and application thereof, belonging to the technical field of petrochemical industry. The microemulsion-type fracture acidizing cleanup additive is prepared from the following components in percentage by weight:5-10% of surfactant, 2-8% of cosurfactant, 35-45% of oil phase, 35-45% of water phase and 3-10% of inorganic electrolyte. The microemulsion-type fracture acidizing cleanup additive provided by the invention has a function of restoring reservoir permeability; and compared with the existing cleanup additive system, the microemulsion-type fracture acidizing cleanup additive provided by the invention can reduce the degree of reservoir damage, which is caused by incompatibility of water locks, residues and formation fluids in the wellbore area of an oil well in the fracture acidizing process of an oil and gas well, by more than 50%.

The present invention belongs to the field of water-soluble functional high-molecular nano material, in particular, it relates to a nano water-soluble microgel oil displacement material and method for preparing said nano water-soluble microgel oil displacement material by adopting inverse microemulsion ligh-polymerization process. It is characterized by that said invention utilizes acrylamide / anionic monomer / third monomer to synthesize ternary copolymer nano-size microgel oil displacement material. Besides, said invention also provides the concrete steps of its preparation method.

Disclosed and claimed is a microemulsion flowback aid composition and a method of enhancing recovery of oil or gas during fracturing or stimulation processes. The microemulsion flowback aid composition includes (i) an oil-like phase comprising at least one nonionic surfactant having a hydrophilic-lipophilic balance (HLB) of less than about 9; (ii) a coupling agent capable of stabilizing the microemulsion flowback aid composition; (iii) at least one water-soluble or dispersible nonionic surfactant that is different from the at least one nonionic surfactant in the oil-like phase; (iv) at least one additional surfactant selected from anionic, cationic, amphoteric, and combinations thereof; and (v) water.

The invention relates to a harsh oil deposit reversed-phase microemulsion profile-control flooding system and a preparation method thereof. The problems in the prior art that the initial particle size of the product is improper and polymeric microspheres are poor in expansibility under high-temperature high-salt conditions are mainly solved. The harsh oil deposit reversed-phase microemulsion profile-control flooding system disclosed by the invention comprises the following components in parts by weight of microemulsion: 20-70 parts of an oil-soluble solvent, 5-20 parts of an emulsifier and a co-emulsifier, 20-70 parts of a polymer aqueous phase containing acrylamide and other temperature-resistant salt-resistant comonomers. According to the technical scheme, a semi-continuous reaction method is adopted, the aqueous phase containing acrylamide and other temperature-resistant salt-resistant comonomers is added into an oil phase containing the emulsifiers in batches, and a hydrophobic monomer is added, so that the problems are solved, the prepared polyacrylamide reversed-phase microemulsion is directly compounded or is compounded with other oil field chemicals to be applied to such field applications for improving oil recovery as depth profile control, water plugging and displacement in tertiary oil recovery of a harsh oil deposit.

A non-toxic oil-in-water or bicontinous microemulsion used as a pharmaceutically acceptable vehicle for administration of one or more active compounds having a low solubility in water as well as a process for the preparation and the use thereof.

The invention provides a transdermal, transmucosal pharmaceutical composition suitable for substantially extra-vascular application of at least one biologically active substance to biological membranes of a mammal, comprising a pharmaceutical or cosmetic composition comprising propylene carbonate at least one oil or source of fatty acid or surfactant; and water; in combination with the at least one biologically active substance wherein the propylene carbonate is adapted to enhance the bioavailability of the at least one biologically active substance.

The invention relates to a preparation method of a profile control and oil displacement system of polyacrylamide nanometer microsphere with low interfacial tension, which comprises the steps of: inversely preparing microemulsion with oil phase, combined emulsifying agents and water phase containing crosslinking agents, initiating polyreaction with a redox initiation system used as initiating agents, neutralizing the obtained polyacrylamide nanometer microsphere with alkali, and preparing highly active sulphonate or carboxylate surfactants with the reaction of the alkali and the substance of organic acid in the combined emulsifying agents; the oil water interfacial tension can be greatly reduced by the surfactants. The profile control and oil displacement system is applied to enhancing enhanced recovery ratio, has good effect on enhancing oil cleaning efficiency, and is a novel profile control and oil displacement system with the dual functions of profile control and oil displacement.

Methods and compositions comprising an emulsion or a microemulsion for use in various aspects of the life cycle of an oil and / or gas well are provided. In some embodiments, the emulsion or the microemulsion comprises water, a solvent, and a surfactant, and optionally, one or more additives.

Described herein are cyclodextrin-stabilized microemulsion systems useful for increasing the solubility, stability, bioavailability, or safety of an active agent for delivery to the skin. The microemulsions may reduce the occurrence of skin irritation or odor upon application. In certain embodiments, the active agent is substantially insoluble in water. The microemulsions may be formulated as semi-solids, for example creams, or as aerosol or non-aerosol foams. Also described are methods of treating skin disorders, comprising the step of applying to an affected area of a subject in need thereof a therapeutically-effective amount of an inventive microemulsion.