53 results about "Polymeric nanoparticles" patented technology

A construction and use of an environmentally adaptive co-regulated mRNA nanodelivery system. By incorporating EACR molecules into mRNA nanoparticles, the microenvironment is remodeled to be suitable for robust and sustained mRNA expression, while tissue damage associated with the self-immunogenicity of mRNA drugs is avoided. The nanodelivery system is compatible with ionizable lipid nanoparticles, cationic liposomes, cationic nanoemulsions, and polymeric nanoparticles. The EACR molecules include: anti-inflammatory drugs, tyrosine kinases / adaptors, JAK / STAT and MAPK pathway inhibitors, nutrients and metabolites, membrane transporters / ion channels, phosphodiesterase and cellular stress inhibitors, and natural viral proteins. The therapeutic mRNAs may encode tumor, viral, or bacterial antigens, immunomodulatory factors, therapeutic antibodies, or functional proteins / enzymes, and can play a role in the fields of regenerative medicine, protein supplementation / replacement therapy, targeted gene editing, and immunotherapy.

Described herein is a composite adhesive composition. The composition comprises: a plurality of polymeric nanoparticles dispersed within a (meth)acrylate-based matrix; and the (meth)acrylate-based matrix is derived from a C1 to C12(meth)acrylate ester monomer and a (meth)acrylate macromer. In some embodiments, these composite adhesives show good impact resistance and good dynamic shear resistance. In one embodiment, an ionic liquid is added to the composite adhesive to enable electro-debonding.

The invention discloses a preparation method and application of a nano heat-insulating metal oxide composite coating. The preparation method comprises the following steps: preparing a nano ATO crystal of which the surface contains silicon hydroxyl; preparing polymerizable ATO (antimony tin oxide) nano particles; and uniformly mixing the polymerizable ATO nano particles, the silane modified nano silicon dioxide, the self-emulsifying polyurethane emulsion and the auxiliary agent to obtain the required coating. Nanometer ATO crystallization and surface silicon hydroxyl modification are synchronously completed in a hydrothermal environment, and the problem of uneven coating caused by traditional two-step modification is solved; after the high-temperature reaction, cold ethanol is used for realizing shock cooling to stop crystal growth, so that the problem of thermodynamic instability of the nanocrystalline is solved; the interfacial compatibility is improved by introducing a vinyl-containing siloxane monomer; by compounding the polymerizable ATO nano particles, the silane modified nano silicon dioxide, the self-emulsifying polyurethane emulsion and the auxiliaries, a stable topological structure connected by covalent bonds is constructed, and the aging resistance, the heat insulation property and the adhesive force of the coating are remarkably improved.

A polymeric nanoparticle is disclosed which comprises:(i) at least one disease-associated antigen which is capable of producing a T-cell response, wherein the disease-associated antigen is encapsulated in the nanoparticle;(ii) at least one adjuvant; and(iii) a dendritic cell targeting moiety which is attached to the outer surface of the nanoparticle.Use of the nanoparticle for treating diseases associated with abnormal cell growth or an infection is also disclosed.

Compositions and methods of improving radiation therapy are provided. The composition typically includes an effective amount of 7-DHC or a derivative or analog thereof. The methods typically include administering the composition to a subject in need thereof in combination with one or more doses of radiation therapy, preferably non-ultraviolet radiation therapy. A preferred radiation is ionizing radiation. The compositions and methods can be used to treat tumors, e.g., benign and malignant tumors. Thus, methods of treating cancer are provided. In preferred embodiments, the 7-DHC or a derivative or analog thereof is encapsulated or incorporated into nanoparticles. The particles can be, for example, polymeric nanoparticles, lipoprotein or lipoprotein-like particles, liposomes, inorganic nanoparticles, or a combination thereof. In some embodiments, the 7-DHC or analog thereof is derivatized with a polymer or saccharide, which is some embodiments, can self-assemble into particles. In some embodiments, the nanoparticles further include a targeting agent coupled thereto.

The present invention deals with the development of novel nanocomposite paints for biofouling removal coatings, which result from the mixing of two components, where the first component is an epoxy resin (component A) and the second component is a suitably modified polymerization agent (hardener). These hardeners are modified with hydrophobic nanoparticles based on functional dendritic polymers with symmetric or asymmetric architecture or based on functional inorganic nanoparticles (metal or metalloid nanoparticles or a mixture thereof). Both the polymeric nanoparticles and the inorganic nanoparticles were modified with suitable lipophilic groups. These nanocomposite paints addressed by the present invention exhibit organic microfilm control properties and can be effectively applied to objects immersed in seawater as biofouling removal coatings.

In various embodiments tolerogenic nanoparticles are provided that induce immune tolerance to one or more desired antigen(s) and / or that reduce an immune response to those antigen(s). In certain embodiments the tolerogenic nanoparticle comprises a nanoparticle comprising a biocompatible polymer; an antigen disposed within or attached to said biocompatible polymer where said antigen comprises an antigen to which immune tolerance is to be induced by administration of said tolerogenic nanoparticle to a mammal; and a first targeting moiety that binds to a scavenger receptor in the liver, and / or a second targeting moiety that binds to a mannose receptor in the liver, and / or a third targeting moiety that binds to hepatocytes, wherein said first and / or second and / or third targeting moiety are attached to the surface of said nanoparticle.

The disclosure describes poly(β-thioester) polymers and polymeric nanoparticles, pharmaceutical compositions comprising these materials, their use in the treatment of cancer and infectious disease, and machine learning methods for identifying and selecting them.

Nanoparticle compositions and methods for preparation thereof are provided. The compositions include nanoparticles comprising anionic polymers, therapeutic agents, and cations. Nanoparticles predominantly fall within a diameter range of 10 nm to 80 nm. Method of preparation involves mixing anionic polymers with cations and therapeutic agents in a microfluidic device to produce nanoparticles.

The present invention belongs to the field of catalyst preparation technology, and specifically relates to a Ni-NiO / Fe(OH)3 / CC bifunctional catalyst and its preparation method and application. The present invention uses carbon cloth as a substrate and prepares Ni-NiO / Fe(OH)3 / CC composed of polymeric nanoparticles with interparticle pores by a method combining electrodeposition and chemical precipitation. The catalyst has multiple active components, and the components are tightly combined to form a unique network structure, exposing more active sites, improving electrical conductivity and having high-intensity stability. In addition, through the synergistic effect between different metals, the adsorption Gibbs free energy of the intermediate product can be significantly reduced, thereby improving the catalytic activity of the catalyst material, making it exhibit lower overpotential and faster kinetics, and having good stability. The preparation method of the present invention is simple, the raw materials are easily available, the cost is low, and it is easy to realize industrial production.

Provided herein are nanoparticles comprising a triblock copolymer and a targeting moiety for targeted delivery of one or more therapeutic agents, and formulations thereof. Also provided herein are layered drug delivery vehicles. Further provided herein are methods, or uses thereof, for treating cancers, preferably pancreatic and brain cancers, by administration of the nanoparticles disclosed herein.

Bioadhesive and biodegradable polymeric nanoparticles can be administered intrathecally, for example, via the cisterna magna, into the spinal column to allow widespread distribution for the treatment of tumors such as leptomeningeal metastases. The nanoparticles rapidly spread to all cerebrospinal fluid (CSF) compartments, including the brain parenchyma and spinal column. The bioadhesive nanoparticles penetrate and are retained for long periods of time, during which time they can continue to release drugs. These nanoparticles can be loaded with different therapeutic, preventive, or diagnostic agents, most preferably DNA repair inhibitors, to enhance the killing of leptomeningeal tumors, such as leptomeningeal metastases, and disseminated tumors, such as medulloblastoma. In a preferred embodiment, patients are treated with a combination of a PARP inhibitor and temozolomide.

A transdermal drug delivery (TDD) system is provided accelerating the TDD process through the combination of (1) a micropump, (2) microneedles, and (3) nanoencapsulation. A 3D printed shape memory alloy (SMA) triggered micropump combined with polymeric nanoparticles loaded with a drug can be pumped through integrated microneedles. An SMA spring wire is used to actuate a loaded pumping spring to drive an elastic membrane into a chamber. The system's performance characterized an average membrane speed of 0.28 m / s. The efficacy of the system showed an almost 100% improvement for the total percentage of deposited polymeric nanoparticles over that of the untreated solution. The rapid response and demonstrated efficacy can be aimed for transdermal insulin injection.

A nanoparticle generally includes a stimulus-responsive polymer core and a silica coating disposed on at least a portion of the core. Methods of forming nanoparticles. Methods of administering nanoparticles to a target subject.

Hydrophilic nanoparticles are disclosed comprising CuS and a hydrophobic surface. Also disclosed are amphiphilic polymeric nanoparticles useful in transporting the CuS or other hydrophobic payloads, and composites containing the polymeric nanoparticles and the hydrophobic CuS payloads. This system can be used, for example, to modulate plant growth and development, resulting in improved yields, crop quality, and shelf life.

The present disclosure provides a composition comprising a polymeric nanoparticle encapsulating an antigen and an agonist, wherein the antigen is M2e peptide. The composition may induce the immune response to influenza A. A method for inducing immune response to influenza A is also provided.

A method to precisely tailor the surface topography of polymeric nanoparticles having bound thereto polyalkylene oxide and to improve their systemic circulation and diseased tissue accumulation, based on tuning the architecture of shape-persistent amphiphilic bottlebrush block copolymer (BBCP) building blocks and inclusion of small molecule chemical modifications, has been developed. It was demonstrated that nanoparticle formation and surface topography can be controlled by systematically changing structural parameters of BBCP architecture. The surface topography of PEGylated nanoparticles (nanoparticles having PEO or PEG covalently bound thereto) and the presence of hydrophobic small molecule modifications, cationic small molecule modifications, and / or small molecule modifications containing a positively ionizable atom significantly affects their biological performance.

The present disclosure provides polymeric nanoparticles including block copolymers which possess reactive oxygen species (ROS) quenching units to reduce oxidative stress to prevent neurodegeneration and which can also be used to encapsulate an active pharmaceutical ingredient, a diagnostic marker, or a combination thereof in a pharmaceutical composition. The polymeric nanoparticles of the present disclosure are designed to release ROS quenchers, the active pharmaceutical ingredient, the diagnostic marker, or the combination thereof upon exposure to a pH below about 6.5, exposure to a reactive oxygen species, or a combination thereof. Methods of diagnosing or treating radiotherapy-induced brain injuries in a patient are also described.

The invention belongs to the technical field of dermatology and relates to a dermal filler formulation containing polymeric nanoparticles that creates volume in various parts of the skin for cosmetic or medical purposes, removing lines, wrinkles, irregularities caused by trauma and / or moisturizing, as well as removing or minimizing infections frequently encountered during dermal filler applications.

The present invention relates to a delivery system of thyroid hormones comprising lipid or polymeric nanoparticles, preferably comprising a targeting agent for the TRCP6 receptor. Such a delivery system can be used in the treatment of diabetic cardiomyopathy or diabetic nephropathy.

Hybrid nanoparticles consisting of a polymeric component encapsulating cationic liposomes and / or lipoplexes comprising a cationic lipid and a helper lipid are described, wherein the polymeric component constitutes at least the 80% by weight with respect to the total material constituting the nanoparticles.

The invention relates to a composition for use in the treatment or prevention of one or more unwanted immune responses in a subject, wherein the one or more unwanted immune responses are caused by the use of one or more immunogenic drugs and wherein the composition comprises negatively charged non-polymeric nanoparticles, wherein the negatively charged non-polymeric nanoparticles are selected from the group consisting of at least one of silicon particles, solid lipid particles comprising at least one immune modulating drug and liposomes comprising at least one immune modulating drug.

The present disclosure provides copolymers and glycopeptide antibiotic-loaded polymeric nanoparticles (PNPs) comprising the copolymers as well as charge neutral polymers for targeted and sustained delivery of glycopeptide antibiotics to treat bacterial infections, including but not limited to biofilm bacterial infections. The copolymers are block, alternate, or random copolymers comprising x units of the formulaand y units of the formulawherein Z is an organic moiety, R and R′ are each independently selected from the group consisting of hydrogen and C1-C18 alkyl, each of x and y is an integer of 1 or greater, the sum of x and y is an integer from about 40 to about 714, and y is from about 10% to about 90% of the sum of x and y.

The present disclosure relates to compositions and methods for treating genetic disorders caused by nonsense mutations using anticodon-engineered transfer RNA (ACE-tRNA) constructs. These DNA-based ACE-tRNA constructs are designed to suppress premature termination codons (PTCs) and restore the expression of full-length, functional proteins. The disclosure further provides formulations of ACE-tRNA constructs with poly(amine-co-ester) (PACE) polymeric nanoparticles to improve stability, protect nucleic acids, and enhance delivery to airway epithelial cells. Also described are functionalized ACE-tRNA Picovectors (sLPVs) incorporating targeting elements such as nuclear localization signals (NLSs), nucleolar localization sequences (NoLSs), and DNA nuclear targeting sequences (DTSs) to improve nuclear import and localization.

Disclosed herein are polymeric nanoparticles containing peptides, which provide low burst release and sustained, delivery of the peptides, and pharmaceutical compositions thereof. The polymeric nanoparticles contain a peptide encapsulated or dispersed therein. The nanoparticles can provide sustained release of the peptide, for example, less than 20% of the peptide is released initially (at time 0 hour) following placement into a phosphate buffered saline at pH 7.4 at 37° C. and room pressure. Methods for micronizing a peptide and for preparing polymeric nanoparticles containing solid, micronized peptides are also disclosed. The preparation methods use miscible solvent and non-solvent pairs in phase inversion nanoencapsulation processes. The Gibbs energy of mixing (ΔGMix) between the solvent and non-solvent can be tailored to achieve desired particle size, encapsulation efficiency, and release profile.

Microalgae combined with antibiotic-loaded neutrophil membrane-coated polymeric nanoparticles provide a hybrid microrobot having robust locomotion in the lungs in vivo toward effective treatment of pulmonary and gastrointestinal tract infections. The algae-nanoparticle hybrid microrobots are provided in methods of treatment of disease or conditions by administration for active in vivo delivery of therapeutics to the lungs or gastrointestinal tract. The microrobot system can be applied to treat a wide range of diseases, including viral pneumonia.

The invention discloses a polypeptide modified cationic polymer nanoparticle as well as a preparation method and application thereof, and relates to the technical field of genetic engineering medicine and vaccine manufacturing, the polypeptide modified cationic polymer nanoparticle comprises a cationic polymer nanoparticle PBAE-536 and plasmid DNA which is in electrostatic binding and tight winding with the PBAE-536; the cell-penetrating peptide HIV-TAT is indirectly coupled to the surface of the PBAE-536, the auxiliary peptide HA2-TAT is mixed with the PBAE-536, and the oligopeptide is coupled with a carrier of the PBAE-536 and contains a microtubule related sequence MTAS and a nuclear localization signal NLS; the polypeptide modified cationic polymer nanoparticles have low cytotoxicity, and can enter cells through endocytosis after being incubated with T lymphocytes from peripheral blood for 30 minutes, so that rapid and efficient gene delivery is realized.

Therapeutic compositions for treating a subject, the compositions including a polymeric nanoparticle, an active agent encapsulated within the polymeric nanoparticle, and a delivery vehicle for targeted delivery of the polymeric nanoparticle and encapsulated agent to a target tissue in the subject. The therapeutic compositions can be designed for targeting the destruction of a Nuclei neutrophil extracellular trap (NET) in a venous thrombus in a subject. The active agent can be an enzyme, including deoxyribonuclease 1 (DNase 1) enzyme. Methods of treating a subject using the therapeutic compositions are provided, including methods of treating venous thrombus, deep vein thrombosis, or a related blood clotting disease and / or condition.

Described are new biodegradable nanoparticle platforms for encapsulation and sustained release of protein therapeutics through a scalable and reproducible method. Specifically nanoparticles comprising a complex comprising a protein, or peptide, and a counter ion polymer are described.

A method to precisely tailor the surface topography of polymeric nanoparticles having bound thereto polyalkylene oxide, based on tuning the architecture of shape-persistent amphiphilic bottlebrush block copolymer (BBCP) building blocks, has been developed. It was demonstrated that nanoparticle formation and surface topography can be controlled by systematically changing structural parameters of BBCP architecture. The surface topography of PEGylated nanoparticles (nanoparticles having PEO or PEG covalently bound thereto) significantly affects their biological performance.