106 results about "Superparamagnetism" patented technology

The invention discloses a preparation method of a wool-based nitrogen-doped magnetic biochar material, which comprises the following steps: firstly, impregnating impurity-removed and scale-removed wool in a ferric chloride solution for coordination reaction to obtain a wool / iron complex; adding melamine, metal salt and the wool / iron complex into deionized water, sealing to form a closed environment, and then vibrating to uniformly disperse the metal salt and melamine on the surface of the wool; taking out and drying until no water exists to obtain a metal salt / melamine / wool mixture; carbonizing the mixture in an oxygen-free environment, and removing metal salt and impurities in the product; and drying to obtain the wool-based nitrogen-doped magnetic biochar material. The magnetic biochar material loaded with magnetic nanoparticles is prepared from wool, has excellent adsorption effect and adsorption catalysis effect on complex mixed dye liquor, achieves catalysis and adsorption synergistic integration, has superparamagnetism, and can realize solid-liquid separation and recovery by setting an external magnetic field.

The invention discloses a magnetic hydrogel, a surface modified Ti implant with an anisotropic magnetic hydrogel coating and application of the surface modified Ti implant. Fe3O4 nano-particles are uniformly deposited on carboxylated cellulose nano-fibers and are modified with polydopamine, and the magnetic cellulose nano-particles with high biocompatibility and superparamagnetism are prepared; the particles can sensitively respond to a weak magnetic field; the preparation method comprises the following steps: preparing a polydopamine modified Ti material, doping the polydopamine modified Ti material and a calcium phosphate oligomer into a GelMA hydrogel solution, coating the polydopamine modified Ti material with the solution, forming an anisotropic structure in a magnetic field, and carrying out photo-crosslinking to finally obtain the surface modified Ti implant with an anisotropic magnetic hydrogel coating. The magnetic hydrogel coating has an anisotropic structure and mechanical properties, and can simulate the anisotropy of bones to a certain extent.

The invention discloses a sewage zero discharge treatment device which comprises a sewage treatment tank, a first partition plate, a second partition plate, a third partition plate and a fourth partition plate are arranged in the sewage treatment tank, a closed area between the third partition plate and the fourth partition plate forms a collection pool, and a rotating magnetic field device is arranged on the periphery of an anaerobic pool. The rotating magnetic field device generates a rotating magnetic field, ferroferric oxide nanoparticles with the surfaces modified with sulfonic acid groups exist in the anaerobic tank, the ferroferric oxide nanoparticles have superparamagnetism and are driven by the rotating magnetic field to form a directional vortex flow, and the ferroferric oxide nanoparticles adsorb protons and load anaerobic microorganisms. A magnetic biological membrane is formed, meanwhile, the mixed mass transfer efficiency of microorganisms and sewage is enhanced through the directional vortex flow, an ultrasonic vibrator array is arranged at the bottom of the aerobic tank, and a collecting device is arranged above the sewage treatment tank.

The invention provides a fluorescent / photo-thermal dual-mode sensor constructed based on an entropy-driven DNA molecular machine as well as a construction method and application of the fluorescent / photo-thermal dual-mode sensor, and belongs to the technical field of sensor construction and analytical testing. The fluorescent / photo-thermal dual-mode sensor is constructed on the basis of Ag (at) Au NPRs with good photo-thermal performance, CdTe QDs with strong fluorescence signals, a Fe3O4 (at) SiO2 nano material with superparamagnetism and an entropy-driven DNA molecular machine signal amplification strategy capable of being specifically combined with miRNA; the fluorescence detection range of the fluorescence / photo-thermal dual-mode sensor is 1 fM to 50 pM, the detection limit is 0.34 fM, the photo-thermal detection range is 1 pM to 1 nM, and the detection limit is 0.5 pM; the fluorescent / photo-thermal dual-mode sensor is simple in construction method, convenient and rapid in detection and high in selectivity, has very good practicability and has very good application in miRNA detection.

The invention discloses a magnetic porous microsphere for in-vitro diagnosis and a preparation method of the magnetic porous microsphere, and belongs to the technical field of preparation of micro-nano materials. According to the invention, styrene is used as a polymerization monomer, and a dispersion polymerization method is adopted to prepare monodisperse polystyrene microspheres; ferric chloride and ferrous sulfate are selected as precursors, magnetic nanoparticles are synthesized through a coprecipitation method under the alkaline condition, the initial loading capacity is changed, the magnetic nanoparticles are loaded on the surfaces and in pore channels of polymer porous microspheres through a multi-step seed growth method, and the magnetic nanoparticles are prepared. The composite magnetic polystyrene microspheres with high magnetic content, good magnetic responsiveness and superparamagnetism are synthesized; finally, functional groups are introduced to the surfaces of the magnetic spheres by monomers containing the functional groups through a monomer swelling polymerization method, and the prepared magnetic porous microspheres have the advantages of uniform particle size, small coefficient of variation and large specific surface area, and can be better combined with antigens and antibodies, so that in-vitro diagnostic function detection such as nucleic acid extraction and chemiluminescence is carried out.

The invention provides a preparation method of streptavidin magnetic beads, and relates to the technical field of preparation of polymer composites.The preparation method comprises the steps that S1, PS / SiO2 composite microspheres are prepared; s2, carboxyl magnetic beads are prepared on the basis of the PS / SiO2 composite microspheres prepared in the step S1; s3, activating the carboxyl magnetic beads; s4, carrying out covalent coupling on the carboxyl magnetic beads and streptavidin; step S5, stripping of the physically combined streptavidin; and S6, sealing and storing the streptavidin magnetic beads. The streptavidin magnetic beads prepared through the method are controllable in particle size, superparamagnetic, good in stability and high in activity, compared with a traditional method, a cross-linking agent does not need to be additionally added, the process is effectively simplified, the cost is reduced, the streptavidin magnetic beads have excellent performance in the using process of a chemiluminescence platform, and the process is easy to amplify and beneficial to control.

The invention provides double-signal sensing gel skin as well as a preparation method and application thereof, and relates to the technical field of flexible sensing. The preparation method of the double-signal sensing gel skin comprises the following steps: dispersing superparamagnetic ferroferric oxide colloidal nanoparticles in a hydrogel precursor solution to obtain a gel solution, and curing the gel solution in a magnetic field to obtain the gel skin, uniformly mixing water and glycerol, and adding anhydrous lithium chloride powder for multiple times under an ultrasonic condition to obtain a displacement liquid; completely immersing the gel skin into the replacement liquid to obtain the double-signal sensing gel skin. Superparamagnetic ferroferric oxide colloidal nanoparticles are used as a photonic crystal color-changing material to realize optical sensing, a glycerol / water binary solvent is used as an environment-resistant solvent to improve the low-temperature environment tolerance of gel skin, and anhydrous lithium chloride is used as a high-conductivity unit and a self-regeneration material to realize self-regeneration of the gel skin. Anhydrous lithium chloride and glycerol generate a synergistic effect of reducing the freezing point, and almost no ice crystal is formed within the temperature change of 20-40 DEG C.

The invention discloses a tree-shaped heavy oil demulsifier with magnetic response as well as a preparation method and application thereof. The demulsifying agent comprises composite magnetic nano particles, the composite magnetic nano particles are provided with magnetic particle inner cores and polymers coated on the outer surfaces of the magnetic particle inner cores, the magnetic particle inner cores are modified superparamagnetic ferroferric oxide nano particles, and the polymers are alkyl phenolic resin polyoxyethylene polyoxypropylene ether. Rapid demulsification of the emulsion with the magnetic response effect at the low temperature is successfully achieved, the using amount of magnetic particles is small during demulsification, and the demulsification process is environmentally friendly, efficient and low in cost.

The invention relates to the technical field of oil gas well tracing monitoring, in particular to a preparation method and application of an oil gas well tracing monitoring magnetic nano tracer agent. Comprising the following steps: dissolving FeCl3, FeSO4. 7H2O and doped metal salt in water, and introducing N2 to remove oxygen; the initial reaction temperature is 85 DEG C, rapidly adding ammonia water, reacting to generate Fe3O4 nanoparticles, doping elements, reducing the temperature to 60 DEG C, and firstly adding sodium citrate for primary carboxyl modification; adding a mixed solution of oleic acid and PEG twice; the pH value of the reaction system is controlled to be 9.5-10.5 in the whole process. The method has the beneficial effects that the doping amount is remarkably increased, the doping amount of doped elements is multiple times of that in the prior art, and the detection sensitivity is remarkably improved; in addition, oleic acid / PEG composite modification is adopted instead of single citric acid modification, so that the tracer is kept stably dispersed in high-salinity formation water; the superparamagnetism facilitates magnetic separation and recovery, and is suitable for harsh formation conditions.

The invention relates to a method for preparing superfine magnetic iron oxide nanoparticles by using liquid nitrogen as a reaction medium, which comprises the following steps: S1, dropping a mixed aqueous solution containing Fe < 3 + > and Fe < 2 + > as a precursor solution and ammonia water into the liquid nitrogen at the same time; s2, stirring while adding ammonia water, and when the mixed solution becomes black, adding oleic acid for particle coating to obtain nanoparticles; and S3, sequentially washing the nano-particles with deionized water and acetone, collecting, filling liquid nitrogen into the obtained nano-particles, and freeze-drying to obtain the superfine magnetic iron oxide nano-particles. The method is easy to operate, the agglomeration phenomenon is effectively prevented under the low-temperature condition of liquid nitrogen, and the prepared nanoparticles have better dispersity and magnetism; due to the use of liquid nitrogen in the reaction process and a subsequent freeze-drying method, the formation of superfine nano-particle powder with uniform size is effectively realized, and the obtained nano-particles have superparamagnetism; the method is environment-friendly and low in cost.

The invention discloses a mesoporous channel internal immunoassay analysis model constructed based on core-shell structure magnetic hierarchical porous ZIFs and a preparation method and application thereof.The preparation method comprises the steps that mesoporous ZIF-8 grows outside Fe3O4 magnetite nanoparticles through a soft template oriented self-assembly and constrained growth mechanism, and a superparamagnetic core-shell structure Fe3O4-coated HMZIF-8 with Fe3O4NPs as a core and HMZIF-8 as a shell is obtained; the structure is used for constructing an in-mesoporous immunoassay analysis model. According to the immunoassay analysis model disclosed by the invention, a stable microenvironment is provided by virtue of a large mesoporous channel so as to maintain the recognition capability of a captured antibody, the sensitivity of immunoassay is remarkably improved, the content of low-concentration cTnI in serum can be accurately quantified, and the luminous quantitative detection on the cTnI in a complex biological sample is not interfered. A novel nano platform for accurately diagnosing different diseases is obtained by changing the type of a primary capture antibody of IMIA.

An object of the present application is to provide a magnetic particle including a secondary particle in which a plurality of primary particles are aggregated, each primary particle having a particle diameter deemed to exhibit superparamagnetism, and the secondary particle exhibiting a larger particle diameter. [Solution] This object is achieved by magnetic particles including secondary particles in which a plurality of primary particles are aggregated, in which the secondary particles have an average particle diameter of 500 nm or more and 5000 nm or less, and in which the plurality of primary particles have an average particle diameter of 2 nm or more and 20 nm or less.

The invention belongs to the technical field of magnetic nano materials, and particularly relates to a preparation method of nickel-chelated agarose magnetic beads with uniformly dispersed magnetic cores. The preparation method comprises the following steps: preparing Fe3O4 magnetic nanoparticles through a coprecipitation method, modifying the Fe3O4 magnetic nanoparticles through a sodium citrate solution to obtain a super-stable magnetic fluid, mixing the super-stable magnetic fluid with an agarose solution, adding the mixture into an oil phase, emulsifying the mixture to obtain superparamagnetic agarose composite microspheres with uniformly distributed magnetic substances, and grafting IDA spacer chelated nickel ions on the surfaces of the superparamagnetic agarose composite microspheres so as to obtain the super-paramagnetic agarose composite microspheres. The IDA-Ni agarose magnetic beads with uniformly distributed magnetic substances are obtained, the IDA-Ni agarose magnetic beads have good suspension stability and can realize separation and purification of tag proteins, the separated and purified proteins are high in purity, and the problems that existing agarose magnetic beads are incomplete in magnetic separation and rapid in precipitation are solved.

The invention provides a magnetic nano material for enriching benzimidazole compounds and application of the magnetic nano material. The magnetic nano enrichment material comprises a core body, wherein the core body is composed of superparamagnetic ferroferric oxide; the shell covers at least part of the surface of the core body, and the shell is made of a covalent organic framework material formed by a repeating unit as shown in a formula I in the specification. The enrichment material has a porous and ordered crystal structure and a high specific surface area, and shows excellent adsorption performance, including high adsorption capacity, rapid adsorption kinetics, good selectivity and reusability. Therefore, the benzimidazole compound in a complex sample can be efficiently enriched and purified, and an effective means is provided for trace detection of the compound residues in a food matrix.

The present application relates to a kind of high-throughput staphylococcus aureus enterotoxin microfluidic chip detection method and application based on chain quantity amplification enhanced fluorescence.The microfluidic chip is provided with fluorescence sensor, and the fluorescence sensor includes identification probe and signal probe;The identification probe is composed of magnetic nanoparticle, nucleic acid aptamer H1 of target to be measured and target aptamer complementary chain H2, and the signal probe is composed of nanomaterial with signal amplification function and three oligonucleotides H3, H4, H5.The present application combines MNPs-ssDNA-AuNPs sandwich structure system and microfluidic chip, realizes detection signal amplification using the excellent superparamagnetic property of MNPs and the high loading capacity of AuNPs, constructs high-throughput, high-sensitivity fluorescence sensing technology for SEA, SEB and SEC1 detection, simplifies experimental process, and builds the rapid, efficient detection platform of multiple pollutants in food.

The invention discloses an acanthosphere-shaped multi-interface type metal oxide magnetic particle and a preparation method and application thereof.The magnetic particle comprises a core composed of magnetic nanoparticles and a shell layer composed of titanium oxide nanosheet spines arranged in a radial mode, and the magnetic particle has superparamagnetism, high specific surface area and rich active sites; and a large number of trap spaces matched with the exosome scale range, so that the method can be used for efficiently enriching and separating the exosome from the biological fluid. Meanwhile, the magnetic core has an out-phase junction composed of amorphous phase titanium oxide and anatase phase titanium oxide, a heterojunction interface composed of titanium oxide and the magnetic core and an ordered spine microstructure, the synergistic effect of the multi-interface effect and the point effect is fully exerted under laser irradiation, the excellent ultraviolet absorption capacity and electron-hole separation efficiency are shown, and the magnetic core has the good application prospect. The method is used for laser desorption ionization mass spectrometry, efficient in-situ pyrolysis of the exosome is achieved, desorption and ionization of metabolite in a lysis solution are promoted, and a high-resolution mass spectrum of the metabolite of the exosome is obtained.

The invention relates to a magnetic mesoporous material based on functionalised silica (3MS-f), the method comprising the steps of: i) hydrolysing and precondensing, in an acid medium, a silica precursor (SiO2) in the presence of a porogen compound having the formula (POE)n-(POP)m-(POE)n wherein: -POE is a polyoxyethylene block; -POP is a polyoxypropylene block; -n is equal to 20 or 106 and -m is equal to 70; ii) incorporating silica-coated superparamagnetic iron nanoparticles into the precondensed mixture obtained in step i) and continuing the condensation; iii) removing the porogen agent from the obtained condensed structure, whereby an organised magnetic mesoporous material based on silica (3MS) is obtained; iv) functionalising the material (3MS) obtained in the preceding step by covalently grafting at least one reactive function that is capable of forming a weak bond with at least one organic molecule of interest (MIO), the weak bond being selected in particular from among electrostatic bonds between oppositely charged groups such as carboxylate / ammonium, phosphonate / ammonium or sulphonate / ammonium and hydrophobic bonds such as bonds between alkyl chains or between aromatic groups; v) optionally, recovering the functionalised magnetic mesoporous material based on silica (3MS-f) obtained in the preceding step.

[Problem] To provide a superparamagnetic tunnel junction element and a computing system using same, the tunnel junction element having excellent operation stability (robustness) against an external magnetic field and being suitable for the computing system based on probabilistic computing. [Solution] This superparamagnetic tunnel junction element 10 comprises a first ferromagnetic layer group 14 including a ferromagnetic material, a second ferromagnetic layer group 12 including a ferromagnetic material, and a barrier layer 13 disposed between the first ferromagnetic layer group 14 and the second ferromagnetic layer group 12, wherein: the first ferromagnetic layer group 14 includes a 1-1st ferromagnetic layer 14A_1, a 1-2nd ferromagnetic layer 14A_2, and a first non-magnetic bonding layer 14B_1; the 1-1st ferromagnetic layer 14A_1 is composed of a ferromagnetic material, and the magnetization direction thereof varies with a first time constant; the first time constant is one second or shorter; and the first non-magnetic bonding layer 14B_1 contains at least one among Ru, Ir, Rh, Cr, and Cu.

Disclosed herein are methods and kits for purifying therapeutic-grade plasmid DNA using magnetic particles. In particular, the technology of the present disclosure relates to methods and kits for purifying therapeutic-grade plasmid DNA at a high degree of purity using magnetic particles with a siliceous oxide surface layer and a superparamagnetic core.

To provide: a fine particle which has superparamagnetism and which does not deteriorate when brought into contact with water; and a production method thereof.SOLUTION: A fine particle (1) according to the present invention includes γ-Fe2O3(5) contained in a matrix phase (3) containing SiO2. In the fine particle, an atom ratio (Si / Fe) between a silicon atom derived from SiO2 and an iron atom derived from γ-Fe2O3 is preferably 0.050 to 0.500, a coercive force is preferably 480A / m or less, and a saturation magnetization is preferably 40A m2 / kg or more.SELECTED DRAWING: Figure 1

The invention relates to a preparation and application method of a controllable microbial carrier, and belongs to the field of perishable organic solid waste biological treatment. The preparation method comprises the following steps: (1) modifying ferroferric oxide with oleic acid; and (2) synthesizing porous magnetic microspheres on the surface of oleic acid modified ferroferric oxide by a suspension polymerization method, namely the controllable microbial carrier. The obtained carrier has the advantages of porosity, superparamagnetism, large surface roughness, large particle size and the like, functional microbial flora can be effectively enriched and fixed, and the bioconversion efficiency of organic solid waste is greatly improved. The carrier can be regulated, controlled and recycled through an exogenous magnetic field, and meanwhile, a solid substrate and functional microorganisms in an organic solid waste aerobic or anaerobic biological treatment system can be effectively separated.

The present invention provides a tunneling magnetoresistance, a manufacturing method thereof, and a tunneling magnetic device. The tunneling magnetoresistance includes: a pinned layer; a free layer disposed opposite to the pinned layer, the free layer being a superparamagnetic layer, and the thickness of the free layer being less than or equal to a critical thickness; and a tunneling barrier layer located between the pinned layer and the free layer. In the tunneling magnetoresistance, a superparamagnetic layer with a thickness less than or equal to the critical thickness is selected as the free layer. During the magnetization process, the magnetic moments of the single-domain particles constituting the superparamagnetism can be oriented in the same direction to reach magnetic saturation, and the magnetic susceptibility is relatively high. Therefore, the tunneling magnetoresistance provided by the present invention has a large saturation field and a large linearity.

The present invention provides an EMI shielding device including a flame retarding, thermal interface material composite with a through plane thermal conductivity of no less than 30 W / mK and a dielectric withstanding voltage of no less than 1 kV / mm, where the composite includes at least one dielectric layer of self-aligned, carbon-based materials associated with superparamagnetic particles and at least one layer of fillers including a blend of dielectric heat transfer materials with a thermal or UV curable polymer or phase change polymer. The anisotropic heat transfer carbon-based materials associated with superparamagnetic materials are aligned under a low magnetic field strength of less than 1 Tesla to an orientation that results in a high thermal conductivity direction which can conduct the maximum heat from the adjacent device of the present composite. The present invention also provides a method for preparing the composite.

The application provides a superparamagnetic conductive fluid material, a preparation method thereof and a magnetically connected laminated photovoltaic module; the preparation method comprises the following steps: a) dissolving FeCl2*4H2O and FeCl3*6H2O in water, then adding an NH3*H2O aqueous solution to carry out a coprecipitation reaction, separating and cleaning a solid product to obtain a Fe3O4 magnetic fluid; b) mixing the Fe3O4 magnetic fluid obtained in the step a) with a nano-silver conductive adhesive and a diluent, and carrying out ultrasonic dispersion to obtain the superparamagnetic conductive fluid material. Compared with the prior art, the application first synthesizes a superparamagnetic conductive fluid material, then coats the superparamagnetic conductive fluid material on a battery sheet overlapping connection setting area in a coating mode, the superparamagnetic conductive fluid material is rapidly magnetized under the action of a magnetic field, and loses magnetism rapidly after the external magnetic field disappears; when a single battery sheet has a defect, the damaged battery sheet can be easily disassembled and replaced, so that the waste of the battery sheet is reduced; meanwhile, the superparamagnetic conductive fluid material can also be used for the recycling and disassembly of the module after retirement.

The present invention relates to an apparatus for softening a crystalline lens nucleus (100) in a cataract phacoemulsification treatment comprising an electric current pulse generator (11) to supply a pulse current to a handpiece (12), wherein the pulse current generates a pulsatile magnetic field, and to hydrodissect the lens nucleus with iron oxide nanoparticle solution to loosen the lens nucleus as well as to infiltrate the lens nucleus (14) with the iron oxide nanoparticles (13), characterised in that the needle tip (24) of the handpiece (12) conducts the generated pulsatile magnetic field to the lens nucleus which causes vibration of iron oxide nanoparticles which emanates a mechanical force to break interdigitating bonds between lens fibers, leading to a controlled softening and fragmenting of the lens nucleus, wherein the electric current pulse generator (11) is configured to produce pulse currents with adjustable voltage and frequency parameters, and the iron oxide nanoparticle solution (13) further comprises a superparamagnetic property functionalised with a biocompatible coating.

The invention relates to the technical field of semiconductor photocatalytic materials, in particular to a preparation method of a spherical Fe3O4 (at) ZnO nanosheet photocatalyst. According to the method, in an ethylene glycol solvent, Fe < 3 + > is used as an iron source, sodium acetate is used as a precipitator, PEG-1000 is used as a morphology guiding agent, and monodisperse spherical Fe3O4 is prepared through a hydrothermal method; then dispersing the spherical Fe3O4 into an aqueous solution containing PEG-20000 and PVP (Polyvinyl Pyrrolidone), and growing a ZnO nanosheet precursor on the surface of the spherical Fe3O4 through hydrothermal reaction again by taking zinc acetate as a zinc source and urea as a homogeneous precipitator; and finally performing high-temperature calcination to obtain a final product. Through the synergistic effect of the two-step hydrothermal method and the surfactant, tight heterojunction compounding of Fe3O4 and ZnO is realized, and the prepared catalyst has high specific surface area, rich active sites and superparamagnetism. The catalyst disclosed by the invention shows excellent photocatalytic degradation activity and cycling stability to organic pollutants under visible light, can be quickly separated and recycled by utilizing an external magnetic field, and has a wide application prospect in the field of wastewater treatment.

The invention discloses boron-rich magnetic nanoparticles and a preparation method and application thereof.The boron element content of the boron-rich magnetic nanoparticles is as high as 9-15 wt%, the boron-rich magnetic nanoparticles are prepared through a one-step solvothermal method, an iron oleate precursor, boric acid, phenyl ether and polyethylene glycol dicarboxylic acid are mixed, and then the mixture is subjected to a three-stage temperature programming reaction at the temperature of 90-120 DEG C, 180-220 DEG C and 250-270 DEG C to obtain the boron-rich magnetic nanoparticles; the prepared boron-rich nanoparticles are uniform in particle size and good in dispersity, have both high boron loading and superparamagnetism, and can significantly improve the tumor killing efficiency of BNCT and reduce the drug toxicity; the superparamagnetism can realize active targeting delivery guided by an external magnetic field, and the magnetic resonance imaging contrast agent can be used for avoiding the risk of magnetic agglomeration at the same time; fluorescence labeling and cell membrane or specific cell membrane protein modification are easily performed on the surfaces of the particles, so that the treatment effect is enhanced, and diagnosis and treatment integration guided by multi-modal imaging is realized; the boron-rich nanoparticles are simple and convenient in preparation process and easily available in raw materials, and have wide application prospects in tumor boron neutron capture therapy drugs.

The invention relates to Calpeptin magnetic nano drug-loaded particles of a targeted enrichment membrane layer and application, and belongs to the technical field of biological medicines. The invention designs a Calpeptin magnetic nano drug-loaded particle for targeting a middle membrane layer, the Calpeptin magnetic nano drug-loaded particle adopts a core-shell structure, a magnetic core is composed of superparamagnetic ferroferric oxide nano particles, and the core endows the material with response ability to an external magnetic field, so that the material can be used for preparing the drug-loaded particle. The polymer shell layer is formed by wrapping the surface of the magnetic core with polydopamine (PDA), and Calpeptin is covalently connected to a polydopamine shell. The Calpeptin magnetic nano drug-loaded particle disclosed by the invention solves the technical problem that a composite material cannot efficiently penetrate through an aorta wall and is specifically enriched in a middle membrane layer, so that a reliable directional intervention scheme with in-vivo experimental evidence support is provided for accurate treatment of TAAD.