55results about How to "Magnetically responsive" patented technology

The present invention relates to a magnetic fluorescent double-functional microsphere with core-shell structure and its preparation method. Firstly, said invention uses strong acid and sodium citrate to modify surface of inorganic magnetic nano granules, then uses alkyl orthosilicate as precursor body, and adopts gel-sol process to prepare silicon dioxide magnetic microsphere with core-shell structure, finally utilizes the copolycondensation method of alkyl orthosilicate and silane coupling agent of bonded fluorescein to prepare silicon dixide fluorescent microsphere with magnetism. Said microsphere has magnetic response characteristic, and can send out fluorescence under the excitation of UV-light and visible light.

The invention provides a method for preparing lysozyme molecular imprinting nano particles with magnetic responsiveness and extremely high adsorption capacity. In the method, lysozymes are used as template molecules. The method comprises the following steps of: carrying out template polymerization under the conditions that suitable functional monomers, a cross-linking agent and an initiator and magnetic nano particles the surfaces which are coated with SiO2 and are modified by sulfydryl and acryloyloxy exist; and washing out the template molecules to obtain the lysozyme molecular imprinting nano particles with magnetic responsiveness and high adsorption capacity. The invention also provides a method for preparing the nano particles. The lysozyme molecular imprinting nano particles prepared by adopting the method disclosed by the invention have the characteristics of high adsorption capacity, simpleness for preparation, low cost, strong specific absorption, high physical, chemical stability, capability of being recycled repeatedly and the like.

The present invention belongs to the field of inorganic material technology, and is especially one kind of magnetic metal oxide microsphere in core-shell structure and its preparation process. The microsphere has ferroferric oxide microsphere as the core and metal oxide as the shell. It is prepared through the first hydrothermal process to cover one layer of amorphous carbon onto ferroferric oxide microsphere to form magnetic carbon microsphere Fe3O4@C, the subsequent dispersing microsphere Fe3O4@C in alcohol water solution of pre-hydrolyzed metal alkoxide for adsorbing inorganic oligomer to the surface of the microsphere, and the final calcining in nitrogen atmosphere to obtain the magnetic metal oxide microsphere in core-shell structure. The process is simple and practical, and has adjustable size of the microsphere. The magnetic metal oxide microsphere has important application in separating protein, separating polypeptide and other fields.

The invention provides carboxyl magnetic microspheres, a preparation method and an application. The surfaces of mesoporous polymer microspheres are modified with functional groups with a physical adsorption method, carboxyl magnetic microspheres are prepared with an in-situ coprecipitation synthesis method, and magnetic microspheres modified with carboxyl repeatedly is prepared by silica coating,amino modification and carboxyl re-modification. The carboxyl repeatedly modified magnetic microspheres are functional composite microspheres, have the advantages of magnetic responsiveness, high stability, better biological compatibility, uniform particle size, good monodispersity, controllable magnetic content and good batch repeatability, are suitable for large-scale stable preparation in industry, and can be widely applied to the fields of cell separation, immune detection, protein purification, immobilized enzyme, environmental protection and the like.

The invention discloses a method for preparing magnetic super-hydrophobic sponge materials. The method includes steps of carrying out cleaning pretreatment on sponges; preparing modified Fe3O4 solution; preparing polydimethylsiloxane solution; preparing magnetic super-hydrophobic sponges. The method has the advantages that the method is economical, environmentally friendly and simple and is high in efficiency, oil or solvents with the volumes dozens of times the volumes of the magnetic super-hydrophobic sponge materials prepared by the aid of the method can be absorbed by the magnetic super-hydrophobic sponge materials, the magnetic super-hydrophobic sponge materials are excellent in oil or organic solvent and water separating capacity, and the oil or the solvents can be quickly recycled by the aid of the magnetic super-hydrophobic sponge materials; the magnetic super-hydrophobic sponge materials are excellent in compression resistance and can be recycled.

The invention relates to a preparation method of nano magnetic particles for detection and treatment of coronary heart diseases, which comprises the following steps: A, mixing transition layer molecules on the surfaces of magnetic nuclei, wherein the transition layer molecule are compounds which simultaneously contain amino groups, carboxyl groups or hydrosulfide groups and groups capable of reacting with hydroxyl groups; B, on the magnetic nuclei fixed with the transition layer molecules, fixing functional molecules capable of prolonging the residence time of nano particles in blood; and C, on the magnetic nuclei fixed with functional molecules, fixing specific recognition ligands of endothelial progenitor cells or diseased endothelial cells, thus obtaining the nano magnetic particles. The method can be used for preparing magnetic nano particles for early-stage detection and location of diseased endothelial cells of coronary heart diseases, and the detection is sensitive and reliable; the method can be also used for preparing magnetic nano particles for mid-late-stage treatment of coronary heart diseases; and good repairing and treatment effects on coronary heart diseases can be achieved.

The invention discloses a preparation method and a using method of a magnetic response aminated cellulose-based heavy metal adsorption material. The preparation method comprises the following steps: S1, crushing cellulose and dissolving the crushed cellulose in an alkali urea solution under stirring state to obtain a transparent cellulose solution; S2, adding an animation reagent and a superparamagnetic material into the cellulose solution, uniformly mixing, then adding a cross-linking agent and grafting the animation reagent to a cellulose chain to obtain modified cellulose; and S3, converting the modified cellulose from liquid state into solid state by adjusting reaction temperature and pH value of a modified cellulose system to obtain the magnetic response aminated cellulose-based heavymetal adsorption material. The magnetic response aminated cellulose-based heavy metal adsorption material prepared by the method has high amino density and magnetic response, is capable of rapidly carrying out solid-liquid separation in an externally-applied magnetic field, has a good effect of removing various heavy metals in water, has good regeneration property, and can be applied to the fieldof treatment of wastewater with heavy metals.

The method for preparing polymer magnetic medicine-loaded particle by utilizing the process using supercritical CO2 to resist solvent mainly includes the following steps: firstly, adding magnetic powder into polymer solution containing medicine, uniformly dispersing said magnetic powder, placing them into reaction still, then injecting CO2 into reaction still according to a certain flow rate, making the solute undergo the supercritical CO2 reversed-phase extraction process, be crystallized, precipitated and separated out, continuously introducing CO2 to clean residual organic solvent to obtain the polymer particle containing medicine and magnetic powder.

The invention provides a clathrate compound of cyclodextrin/Fe3O4 magnetic nano compound and ibuprofen, prepared by adopting the following steps of: adding a cyclodextrin/Fe3O4 magnetic nano compound into ibuprofen ethanol solution in the weight ratio of (0.2-20): 1, and carrying out ultrasonic processing for 2-4 hours; washing products with secondary distilled water, separating by adopting a permanent magnet, and carrying out vacuum drying to obtain the clathrate compound. The cyclodextrin/Fe3O4 magnetic nano compound realizes targeting delivery on a medicine by simultaneously utilizing clathration characteristic of cyclodextrin and magnetic performance of a Fe3O4 magnetic nano particle; the ibuprofen is clathrated by the Fe3O4 magnetic nano compound, adverse effect of the medicine is reduced, peculiar and odour smells of the medicine are covered, solubility, bioavailability and stability are all improved, the clathrate compound can be used for targeting medicine delivery under the action of an external magnetic field, and curative effect of the medicine can be played to the utmost extent.

The invention provides a sulfobutyl ether-beta-cyclodextrin/Fe3O4 magnetic nano particle composite (SBE-beta-CD/Fe3O4MNP), which is prepared by modifying sulfobutyl ether-beta-cyclodextrin with citric acid to introduce carboxyl onto the sulfobutyl ether-beta-cyclodextrin, and subjecting the sulfobutyl ether-beta-cyclodextrin with the carboxyl to dehydration condensation together with Arabic gum modified amino-containing Fe3O4 magnetic nano particles. Characterization by X-ray diffraction (XRD), transmission electron microscope (TEM), dynamic light scattering (DLS), Fourier transform infrared spectroscopy (FTIR) and thermogravimetric analysis (TGA) methods proves the Fe3O4 magnetic nano particles are grafted with sulfobutyl ether-beta-cyclodextrin. The composite can be used as a potential medicinal carrier. The invention also provides the inclusion compound of the composite and ibuprofen, which has high solubility and high biocompatibility and can be used in preparation of ibuprofen targeted medicines.

The invention discloses a preparation method of magnetic immobilized lipase capable of being used in organic media. A magnetic Fe3O4/P(St-AA) nanosphere or a magnetic Fe3O4/ PS-CH3Cl nanosphere is used as a carrier, and the lipase is fixed on the surface of the magnetic Fe3O4/P(St-AA) nanosphere or the magnetic Fe3O4/ PS-CH3Cl nanosphere through covalent binding. The method is simple and moderate, the carrier content of the lipase is high, and the magnetic immobilized lipase has the advantages of high recovery rate, good stability and wide application prospect and can be widely used in the organic media.

The invention provides a magnetic nano material and a preparation method and application thereof. The magnetic nano-material comprises a magnetic core, a silicon dioxide shell and an amphiphilic organic group grafted outside the silicon dioxide shell. The magnetic nano material has the advantages of being uniform in particle size, magnetic responsive, amphiphilic, non-toxic, environmentally friendly and low in production cost; no by-product is generated in the preparation process, the oil-water interfacial tension can be remarkably reduced, and the method has a good application prospect in the field of oil-water emulsion separation.

The invention discloses an anti-counterfeiting adhesive tape with magnetic response and biodegradation functions as well as a preparation method and an application of the anti-counterfeiting adhesive tape. One of a chitosan/polyacrylamide double-cross-linked network, a sodium alginate/polyacrylamide double-cross-linked network, a chitosan/polyacrylic acid double-cross-linked network and a sodium alginate/polyacrylic acid double-cross-linked network is formed on the surface of the base material film, wherein the network formed by chitosan or sodium alginate has biodegradability; meanwhile, Fe3O4 particles with magnetism are introduced into the four double-crosslinking networks, so that the modified base material film with excellent magnetic response and biodegradation functions is obtained, and therefore, the anti-counterfeiting adhesive tape prepared by adopting the modified base material film also has the magnetic response and biodegradation functions. According to the method, the whole operation steps are simple, and implementation feasibility is high; The modification process of the substrate film is carried out in a water-phase environment, so that environmental pollution is avoided.