Cyclodextrin/fe3o4 magnetic nanocomposite and its drug inclusion complex

A technology of magnetic nanoparticles and magnetic nanoparticles, which is applied in drug combinations, antipyretics, pharmaceutical formulations, etc., can solve the problems of strong gastrointestinal irritation, frequent medication to maintain therapeutic concentration, low dissolution rate and bioavailability , to achieve the effect of improving solubility, significant solubilization effect and increasing drug stability

Inactive Publication Date: 2011-11-30
SHANXI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to its insolubility in water, low dissolution rate and bioavailability, frequent medication is required to maintain the therapeutic concentration, and it has a great stimulating effect on the gastrointestinal tract, which limits its application to a certain extent.

Method used

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  • Cyclodextrin/fe3o4 magnetic nanocomposite and its drug inclusion complex
  • Cyclodextrin/fe3o4 magnetic nanocomposite and its drug inclusion complex
  • Cyclodextrin/fe3o4 magnetic nanocomposite and its drug inclusion complex

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1: Fe 3 o 4 Preparation of Magnetic Nanoparticles

[0021] (1) Weigh FeCl with a molar ratio of 1:1 2 .4H 2 O and FeCl 3 .6H 2O (total iron concentration 0.3mol / L) is placed in a 250ml round bottom flask, add an appropriate amount of twice distilled water 194ml, fully stir and dissolve at a speed of 600r / min at a temperature of 30°C, and simultaneously add concentrated ammonia water (25-28%) When the pH is 9 to complete the precipitation, heat up to 80°C and mature for 30 minutes. The reactant is naturally cooled to room temperature, washed repeatedly with double distilled water and ethanol, separated by a permanent magnet, and vacuum-dried at 70°C for 24 hours to obtain Fe 3 o 4 Magnetic nanoparticles (MNP) (see figure 1 ).

[0022] Characterized by X-ray diffraction technique, from figure 2 It can be seen that the peaks at 2θ at 30.2, 35.6, 43.2, 53.7, 57.2 and 62.9 correspond to the face-centered cubic Fe 3 o 4 The (220), (311), (400), (422), (511...

Embodiment 2

[0034] Embodiment 2: sulfobutyl ether-β-cyclodextrin / Fe 3 o 4 Inclusion Compound of Magnetic Nanocomposite and Ibuprofen

[0035] sulfobutyl ether-β-cyclodextrin / Fe 3 o 4 Add 20 mg of the magnetic nanocomposite to the ethanol solution of ibuprofen (containing 16.83 mg ibuprofen), react with ultrasound for 4 hours, wash the product with twice distilled water, separate it with a permanent magnet, and dry it at 50°C for 10 hours to obtain sulfobutyl ether- β-Cyclodextrin / Fe 3 o 4 The inclusion compound of the magnetic nanocomposite and ibuprofen has a measured inclusion rate of 60.91%, and the actual drug content of the inclusion compound is 10.25 mg / g.

Embodiment 3

[0036] Embodiment 3: Sulfonyl ether-β-cyclodextrin / Fe 3 o 4 Inclusion Compound of Magnetic Nanocomposite and Ibuprofen

[0037] sulfobutyl ether-β-cyclodextrin / Fe 3 o 4 Add 20 mg of the magnetic nanocomposite to ibuprofen ethanol solution (containing 9.85 mg ibuprofen), react with ultrasound for 4 hours, wash the product with double distilled water, separate it with a permanent magnet, and dry it at 50°C for 10 hours to obtain sulfobutyl ether- β-Cyclodextrin / Fe 3 o 4 The inclusion compound of the magnetic nanocomposite and ibuprofen has a measured inclusion rate of 57.46%, and the actual drug content of the inclusion compound is 5.66mg / g.

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Abstract

The invention provides a sulfobutyl ether-beta-cyclodextrin/Fe3O4 magnetic nano particle composite (SBE-beta-CD/Fe3O4MNP), which is prepared by modifying sulfobutyl ether-beta-cyclodextrin with citric acid to introduce carboxyl onto the sulfobutyl ether-beta-cyclodextrin, and subjecting the sulfobutyl ether-beta-cyclodextrin with the carboxyl to dehydration condensation together with Arabic gum modified amino-containing Fe3O4 magnetic nano particles. Characterization by X-ray diffraction (XRD), transmission electron microscope (TEM), dynamic light scattering (DLS), Fourier transform infrared spectroscopy (FTIR) and thermogravimetric analysis (TGA) methods proves the Fe3O4 magnetic nano particles are grafted with sulfobutyl ether-beta-cyclodextrin. The composite can be used as a potential medicinal carrier. The invention also provides the inclusion compound of the composite and ibuprofen, which has high solubility and high biocompatibility and can be used in preparation of ibuprofen targeted medicines.

Description

technical field [0001] The present invention relates to drug clathrate, specifically belongs to cyclodextrin / Fe 3 o 4 Magnetic nanocomposites, and their inclusion complexes with ibuprofen. Background technique [0002] Magnetic nanomaterials are nanomaterials with magnetic responsiveness. Commonly used magnetic nanomaterials mainly refer to transition elements such as iron, nickel, cobalt or their alloys, oxides, etc., Fe 3 o 4 Magnetic nanoparticles have attracted special attention because of their high specific surface area, non-toxicity, easy preparation, and rapid response to external magnetic fields. They are widely used in biomedicine, materials chemistry, and separation science, especially in targeted drug delivery. The application of this aspect has attracted the continuous and extensive attention of researchers. [0003] Since the size of the hydrophobic cavity of cyclodextrin is suitable for most of the drug molecules in clinical use or testing, the formed incl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/48A61K47/02A61P29/00
Inventor 董川曹丽燕周叶红双少敏
Owner SHANXI UNIV
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