230results about How to "High drug content" patented technology

The invention discloses a medicine granule containing the following components by mass percent: 75 to 95 of medicine, 2 to 22 of thinner for pelletization, 0.06t to 0.5 of glidant, and 1.5 to 3.5 of adhesive. The invention also discloses a preparation method thereof and a preparation containing same. The medicine granule has high medicine content, round surface, higher rigidity and smaller grain diameter, can be directly used for tabletting, has less weight increment if being coated and can achieve a better taste masking effect. The method for preparing the medicine granule can simultaneously realize pelletization and coating technologies in a tangent spraying fluidized bed, has simple production steps and high efficiency, and can be applied to mass production.

The present invention relates to a fuliconazole injection. Said injection includes the following components; (by wt%) fuliconazole 0.01-20%, cyclodextrin or cyclodextrin derivative 0%-60%, water-soluble excipient 0-75%, solubilizer 0%-20% and the rest is injection water. Its preparation method includes the following steps: mixing the above-mentioned raw materials, using active carbon to remove impurity and heat source, filtering, fine filtering, filling, sterilizing, checking and putting in storage.

[Problems] A derivative of a nucleic acid antimetabolite is demanded which can show a higher therapeutic effect at a lower dose.

[Means for Solving Problems] Disclosed is a high molecular weight derivative a nucleic acid antimetabolite, which is characterized by comprising a high molecular weight compound comprising a polyethylene glycol moiety and a polymer moiety having a carboxyl group in a side chain and a nucleoside derivative which can act as a nucleic acid antimetabolite, wherein the nucleoside derivative is bound to the carboxyl group in the side chain of the high molecular weight compound via a highly hydrophobic linker.

The invention discloses a method for emulsionizing outer gelation and preparing sodium alginate/chitosan slow release micro-capsule in one step. The current preparation method of calcium alginate gel by internal gelation has defects that small parts of the calcium salt granules cannot be richly reacted with glacial acetic acid and remained in the sodium alginate calcium beads, the encapsulization materials are easily lost and the wrapping rate is low due to the calcium salt is difficult to evenly disperse. The invention uses the sodium alginate liquor as the disperse phase, the edible plant oil as the disperse medium and the sorbitan monooleate as the surfactant to emulsionize small liquid drops wrapped with oil; calcium chloride chitosan liquor is used for initiating the gelation reaction of the sodium alginate so as to generate sodium alginate/chitosan slow release micro-capsule; the oil remained on the surface is eliminated by a oil removing device with precipitation self-drifting method. The invention elevates the micro-capsule medicine contents and the wrapping rate.

A cellulose powder which has an average degree of polymerization of 150 to 450, an average particle diameter of 30 to 250 μm, an apparent specific volume exceeding 7 cm³/g, and a retention of polyethylene glycol having a molecular weight of 400 to 190% or higher.

The invention discloses a spinning solution, nuclear shell nanofiber as well as a preparation method and application thereof. A hydrophobic drug and polyvinyl alcohol (PVA)/polyethylene glycol-b-poly(p-dioxanone) (PEG-b-PPDO) are blended to obtain a spinning solution system, and the nuclear shell nanofiber is directly formed by utilizing a single-axis spinneret under a high-voltage electrostatic effect. The preparation method disclosed by the invention has the advantages of simple equipment, mild conditions, simple flow and low energy consumption, can be used for achieving the aims of high-efficiency embedding of the hydrophobic drug, controllable drug release speed and long sustained release time, and is very suitable for industrial production.

The invention relates to a method for producing rifampicin raw material medicines with densities of less than or equal to 0.3g/ml and more than or equal to 0.8g/ml. The recrystallization process for obtaining the rifampicin raw material medicine product with the density of less than or equal to 0.3g/ml comprises the following steps of: dissolving a rifampicin crude product in n-butyl alcohol with stirring, keeping the temperature, and dissolving completely; controlling the concentration of solution; forming a large number of crystal nuclei, adjusting stirring speed, and circularly reducing the temperature; and separating to obtain a wet product by using a centrifugal machine, and performing vacuum drying. The recrystallization process for obtaining the rifampicin raw material medicine product with the density of more than or equal to 0.8g/ml comprises the following steps of: dissolving a rifampicin crude product in acetone with stirring, keeping the temperature, and dissolving completely; controlling the concentration of solution; and putting a previously cleaned and dried stainless steel cylinder into the solution, circularly reducing the temperature, taking the stainless steel cylinder out for later use, putting into a centrifugal machine with continuous stirring, separating to obtain a wet product and performing vacuum drying. By the method, the rifampicin raw material medicines with the densities can be purposefully and effectively produced; and raw material medicine crystals are uniform and ordered, and have high liquidity, low impurity content and high content.

The invention discloses a compound plant enzyme stoste which comprises dozens of fruits/vegetables, 29 traditional Chinese medicines and the like. The compound plant enzyme stoste disclosed by the invention has the following advantages: the formula is precise and rational; first, the fruits/vegetables and traditional Chinese medicines are circularly fermented by composite zymocyte and stored for several years for ripening; then, thousands of enzymes are obtained through chelation and ripening, synergistic interaction is promoted by over 5 times, and overall curative effect is good; and the compound plant enzyme stoste has the functions of promoting production of body fluid and quenching thirst, replenishing qi and invigorating spleen, nourishing yin and strengthening yarn, improving body immunity, strengthening healthy qi, removing toxin and losing weight, reducing blood pressure and blood fat, activating blood and beatifying face, preventing and resisting cancer, resisting aging and the like, improving appetite and recovering constitution. The invention also discloses a functional composite plant enzyme stoste as well as a preparation method and functional food thereof, wherein the functional composite plant enzyme stoste is particularly suitable for losing weight, reducing blood pressure and blood fat, preventing cancer, resisting aging and improving body immunity and physical strength of sub-healthy people and is particularly adapted to the toxicity reducing and effect increasing for physical weakness, low appetite, postoperative rehabilitation and tumor chemoradiotherapy of a patient so as to improve the life quality of the patient.

The invention relates to a preparation method for Chinese herbal medicament nutrient fertilizer containing honeysuckle. The nutrient fertilizer comprises 2,000 g of dry chicken manure, 1,150 g of dry sheep manure, 1,300 g of dry dairy manure, 3,000 g of dry rabbit manure, 3,000g of bean cake powder, 1,000 g of bone meal, 6,000 g of corncob, 2,000 g of beanstalk, 2,000 g of compound fertilizer, 1,000 g of urea, 2,000 g of phosphate fertilizer, 600 g of glucose powder, 300 g of sanmate powder, 1,000 g of panaplate powder and 2,000 g of phenolic resin powder. The preparation method comprises the following steps: taking the powder agents according to the proportion and combining all powder agents together; putting the mixture in a stirrer to stir for 70 minutes; taking out and putting the mixture in a pulverizer to crush the mixture into particles about 60-mesh; putting the particles in the stirrer again to stir for 160 minutes; taking all particles out and pouring all particles in a fermenting tank; adding 1:1.5 human excrement solution to stir up and down and piling up the evenly stirred mixture; and finally, patting the mixture and compacting and tightly covering the mixture by a plastic cloth to carry out fermentation for 26 hours.

The invention provides a compound clobetasol propionate mixed micellar solution. Phosphatide and cholate are mainly utilized to prepare the mixed micellar solution which is used for packaging clobetasol propionate and tretinoin. The mixed micelle solution can be simply prepared, and the medicament stability can be guaranteed in the process of preparation. By preparing a mixed micelle system from the phosphatide and the cholate, the problem of medicament dissolution is solved. Compared with a common ointment, the mixed micelle solution has a higher retention volume on skins, and the quantity of the medicament on local skins and the therapeutic index can be increased. The mixed micelle solution can be further prepared into an ointment and a gel, and is mainly used for treating psoriasis vulgaris, dermatitis, eczema, etc.

The invention provides a high-content toltrazuril soluble powder, as well as a preparation method and application of the high-content toltrazuril soluble powder, relates to the field of the soluble powders, preparation methods and application of the soluble powders, and aims at solving the problems of the existing preparation method that the toltrazuril preparation is low in water solubility, low in bioavailability, poor in stability, and easy to generate precipitate and discolor so that the treatment effects and application of the toltrazuril preparation are greatly limited. The high-content toltrazuril soluble powder is prepared from toltrazuril, an alkaline pH (Potential of Hydrogen) regulator, a cosolvent and a soluble filler in parts by weight. The preparation method comprises the following steps of: 1, weighing; 2, mixing and preparing solution; and 3 preparing the powder by the spray drying process. The application is the application of the high-content toltrazuril soluble powder serving as the raw material in tablet preparations, granular preparations and freeze-dried powder preparations. The preparation method is simple in preparation process; the prepared powder contains the toltrazuril up to 60% and is quick to dissolve; and the preparations can be placed for three years at the room temperature without packing and discoloring. The high-content toltrazuril soluble powder is applicable to the field of veterinary drug preparations.

The invention discloses a clathrate of a mesoporous silicon oxide/Fe3O4 magnetic nano-grade complex and ibuprofen. The clathrate is prepared through the steps that: the mesoporous silicon oxide/Fe3O4 magnetic nano-grade complex is added into an ibuprofen ethanol solution, wherein the mass ratio of ibuprofen to the mesoporous silicon oxide/Fe3O4 magnetic nano-grade complex is 1:0.25-25; the mixture is subjected to ultrasonic treatment for 2-5h; an obtained product is washed by using twice-distilled water; the product is separated by using a permanent magnet; the obtained product is subjected to vacuum drying for 6-8h under a temperature of 50-70 DEG C, such that a solid clathrate is obtained. The clathrate can be used for preparing an ibuprofen targeting medicine. Under the effect of an external magnetic field, the contained medicine can be released at the exact position of a lesion site. Therefore, medicine adverse reactions can be reduced, administration frequencies can be reduced, and medicine maximal curative effect can be developed.

The present invention discloses a gemcitabine chemical transfer prodrug, a preparation method and applications thereof, wherein the gemcitabine chemical transfer prodrug mainly comprises gemcitabine and a dihydropyridine chemical delivery system. According to the present invention, based on the dihydropyridine-pyridine ion oxidation-reduction reaction, gemcitabine and a targeting agent 3-quinolinic acid are bonded to prepare the reduced gemcitabine chemical transfer prodrug, the conjugate is promoted to diffuse into the brain tissue through the high lipid solubility, and in the brain, the pyridine part in the dihydropyridine brain-targeting chemical delivery system conjugate is oxidized into the oxidized gemcitabine chemical transfer prodrug by a coenzyme system; and the gemcitabine chemical transfer prodrug has effects of improvement of the amount of the drug entering the brain, enhancement of the drug efficacy, reduction of the drug consumption, and reduction of the drug toxic-side effect.

The invention provides an antineoplastic compound deacetylase fungus epoxy ethyl ester injection and a preparation method thereof, belonging to a compound. The antineoplastic compound deacetylase fungus epoxy ethyl ester injection can solve the slightly solubility problem of deacetylase fungus epoxy ethyl ester, can increase the oral bioavailability of deacetylase fungus epoxy ethyl ester and hasgood stability. The antineoplastic compound deacetylase fungus epoxy ethyl ester injection is nano suspension freeze-dried powder and comprises deacetylase fungus epoxy ethyl ester, a surface active agent, a suspending agent and a freeze-drying protecting agent in the mass ratio of 1:(0.5-10):(0-10):(2-10). The preparation method comprises the following steps of: putting deacetylase fungus epoxy ethyl ester, the surface active agent and the suspending agent in a container, adding water, predispersing, homogenizing, adding the freeze-drying protecting agent, dissolving by stirring, subpackaging, freezing, and freeze-drying to obtain the antineoplastic compound deacetylase fungus epoxy ethyl ester injection.

The invention discloses a Chinese herbal medicine nutrition fertilizer for Polygonum multiflorum, comprising dried chicken manure, dried sheep manure, wheat straw powder, peanut stem leaf powder, corn stem leaf powder, rapeseed cake meal, rice chaff powder, towel gourd stem leaf powder, phosphate fertilizer, nitrogenous fertilizer, composite fertilizer, zinc fertilizer, trichlorfon, carbendazim, glucose powder, and fennel powder. The nutrition fertilizer disclosed herein has the advantages of, easy obtainment of raw materials, and simple formula and preparation method, and a lot of organic fertilizers generated in the nutrition fertilizer can meet the rapid growth requirements of Polygonum multiflorum.

The invention relates to a preparation method of a concentrated pill made of Chinese traditional medicine for anti-aging effect on brain, adopting the production technique such as alcohol extracting, water extracting-alcohol precipitating, attritioning, concentrating under vacuum , spray drying and vacuum drying in decompression at low temperature and repulverizing respectively according to the properties of different medicinal materials and the efficacies of different medicinal materials in prescriptions to prepare a drug powder. A small amount of the disintegrating agent is added into the powder and then blended; water or the alcohol with certain consistency is taken as wetting agents; then palletizing, polishing, selecting, drying and film coating process are carried out. Or the powder is palletized with over 90 percent alcohol, dried, arranged and then added with a small amount of disintegrating agent and lubricant, pelted by dry method and coated; the concentrated pill made of the Chinese traditional medicine for anti-aging effect on brain is obtained. The pill has high drug content, small diameter and small clinic dose, which is convenient for the patient to swallow and prevents the stomach from being irritated by the capsule shell. With rapid treatment effect and high bioavailability; the film coating process prevents the pill from going bad due to the moisture absorption, and enhances the stability of the preparation.

An inclusion compound used as medicine is prepared from astragaloside A and cyclodextrin through including the astragaloside A by cyclodextrin. Its preparing process is also disclosed. It has the improved solubility and biological utilization rate.

The invention discloses a drug balloon. The drug balloon comprises a balloon body and a drug coating located on the surface of the balloon body, wherein the drug coating comprises a drug and an excipient; the drug coating comprises a near-end coating, a middle-section coating and a far-end coating, the drug-loading density of one of the near-end coating and the far-end coating is larger than the drug-loading density of the middle-section coating, and the drug-loading density of the other one of the near-end coating and the far-end coating is not smaller than the drug-loading density of the middle-section coating. When stent restenosis lesions are treated, the drug balloon is selected to be pressurized according to lesion characteristics, the drug balloon has a supporting function, part ofthe coating with a large drug-loading density is close to severe stenosis lesions at the near end or the far end, the drug content is selectively increased, and the stenosis rate of severe lesion areais reduced; meanwhile, the total drug content of the whole lesions is reduced, and the drug toxicity and adverse reactions of the body are reduced.

The invention provides a taxanes dimer, a preparation method and a preparation thereof and belongs to the field of biological medicine. The problem of low solubleness of the present taxanes drug in water can be solved. The dimer is composed of taxanes and a joint molecule. The taxanes is taxol or docetaxel and the joint molecule is dicarboxylic acid or dicarboxylic acid containing a disulfide bond. The invention also provides the preparation method for the taxanes dimer. The invention also provides the preparation. The preparation contains an amphiphilic polymer and the taxanes dimer. The taxanes dimer provided by the invention has high solubleness in water or injection; the solution has higher storage stability; the taxanes dimer has hydrolysis reaction under a physiological condition; the taxanes drug is released, so that the curative effect can be achieved.

A houttuyninum sodium injection is prepared through dissolving hydroxypropyl beta-cyclodextrin in water for injection while stirring, adding houttuyninium sodium, stirring or grinding and vacuum (or spray) drying or freeze drying. Its advantages are high safety and high stability.

The invention relates to a preparation method for Chinese herbal medicament nutrient fertilizer containing dahuriae angelica root. The nutrient fertilizer comprises 25,000 g of dry chicken manure, 30,000 g of dry rabbit manure, 25,000 g of dry sheep manure, 25,000 g of dry human excrement, 20,000 g of bean cake, 20,000 g of cotton seed cake, 20,000 g of tikitiki powder, 20,000 g of corn flour, 20,000 g of compound fertilizer, 30,000 g of phosphate fertilizer, 10,000 g of urea, 10,000 g of calcium, zinc and potash fertilizer, 1,000 g of panaplate, 1,000 g of paclobutrazol, 2,000 g of glucose powder and 10,000 g of epoxide resin. The preparation method comprises the following steps: taking the powder agents according to the proportion and combining all powder agents together; putting the mixture in a stirrer to stir for 70 minutes; taking the mixture out and putting the mixture in a pulverizer to crush the mixture into particles about 60-mesh; putting the particles in the stirrer again to stir for 160 minutes; taking out and pouring all particles in a fermenting tank; adding 1:1.5 human excrement solution to stir up and down and piling up the evenly stirred mixture; and finally patting the mixture and compacting and tightly covering the mixture by a plastic cloth to carry out fermentation for 26 hours.