156 results about "Improved solubility" patented technology

The invention discloses a method for improving solubility by coordinating walnut meal protein isolate with a metal polyphenol network. The method comprises the following steps: preparing a metal polyphenol network conjugate and forming a ternary graft of the conjugate and walnut protein isolate, the metal polyphenol network conjugate is formed by coordination chelation of caffeic acid and zinc ions; the formation of the ternary graft comprises the step of forming the hydrophilic ternary graft by the caffeic acid-zinc ion conjugate and different proportions of walnut protein isolate under pH cycle induction, so that the zinc-rich walnut protein isolate with remarkably improved solubility is obtained. According to the method, the solubility of the walnut meal protein can be improved to 70.88% from 30.71%, the steps are simple, the safety is high, the period is short, and the method has important significance in expanding the application of the walnut meal protein in the field of food processing.

The invention relates to a stevioside composition, which comprises at least one stevioside and at least one of siamenoside I, mogroside V, mogroside III-E and mogroside II-E, and is characterized in that the stevioside composition comprises at least one stevioside and at least one of siamenoside I, mogroside V, mogroside III-E and mogroside II-E; wherein the stevioside has a higher solubility in the composition than in an equivalent composition lacking siamenoside I, mogroside V, mogroside III-E, and mogroside II-E. The invention also relates to a method for preparing the stevioside composition. The composition may be an aqueous solution.

The present invention relates to a beta-lactam compound and a preparation method and use thereof, the beta-lactam compound has a structure represented by formula (I), n = 0-6, and the X-ray powder diffraction pattern 2theta diffraction angle of the crystal form A has characteristic diffraction peaks at 5.8 + / -0.2 degrees, 10.8 + / -0.2 degrees, 15.3 + / -0.2 degrees, 17.4 + / -0.2 degrees and 18.6 + / -0.2 degrees. The beta-lactam compound of the present invention not only has improved efficacy, but also has improved solubility and stability. # imgabs0 #

The present invention relates to a process for manufacturing dry powder cell culture media. The preparation and usage of mixed particles generated by co-lyophilisation leads to cell culture media with improved solubility without changing the chemical composition.

Provided are long-acting atrial natriuretic peptide (ANP) polypeptides that bind to natriuretic peptide receptors, such as NPR-A, thereby functioning as NPR-A agonists and that exhibit improved stability. The present invention provides atrial natriuretic peptides with specific structural features that result in polypeptides with sufficient activity at NPR-A and also possess a number of other beneficial attributes related to their potential development as therapeutic treatments, including improved solubility of the analogs in aqueous solution, improved chemical and physical formulation stability, an enhanced pharmacokinetic profile, and minimized potential immunogenicity.

The invention discloses an embedding method for stabilizing and slowly releasing beta-carotene. The embedding method comprises the following steps: selecting soybean oil; the stirring conditions are as follows: 300 r / min and 75 DEG C; preparing a water phase: stirring 80 kg of maltodextrin and 20 kg of cane sugar at 50 DEG C until 200 kg of distilled water is completely dissolved; the homogenizing conditions are as follows: the high-speed mixing and shearing emulsifying machine shears for 5 minutes at the speed of 17000 r / min, and the high-pressure homogenizing machine homogenizes for 2 minutes at the pressure of 20 MPa; the spray drying conditions are as follows: the pressure is 0.5 MPa, the inlet temperature is 170 DEG C, and the flow rate is 10 mL / min. The particle size D of the optimized beta-carotene microcapsule product is 95lt; according to the present invention, the prepared nano-particles have characteristics of uniform particle size, 300 nm, embedding rate of 94.2%, good stability in the 90-day storage period, and significantly improved solubility.

A method for improving drug solubility and a drug composite material having improved solubility. The method comprises preparing a silica colloidal suspension from silica nanoparticles having a diameter between 2 nm and 100 nm; rapidly evaporating a solvent by means of controlling the temperature and pressure, so as to obtain a porous surface material with ultra-high density silanol groups retained on the surface; and loading drug molecules. By controlling the size of nanoparticles and the density of silanol groups, drug molecules can be effectively adsorbed under anhydrous conditions, and rapidly desorbed and released in an aqueous environment.

The invention relates to an acid salt of a compound shown as a formula (I), in particular to a hydrochloride of the compound shown as a crystalline form (I) and a preparation method and application of the hydrochloride, and the compound is a PD-1 / PD-L1 inhibitor with the structure of the compound shown as the formula (I). The acid salt of the compound as shown in the formula (I) has improved dissolving capacity in a biological medium, and particularly, the crystalline compound hydrochloride has moderate hygroscopicity, good crystallinity, good solubility and stable physicochemical properties, which all meet the industrial production requirements and meet the development requirements of clinical pharmaceutical preparations. The acid salt or crystalline compound hydrochloride of the compound shown in the formula (I) can be widely applied to preparation of drugs for treating PD-1 / PD-L1 signal channel mediated tumors, immune related diseases and disorders, infectious diseases, infectious diseases or metabolic diseases.

This invention provides a highly water-soluble composition for promoting autophagy and its application. The composition comprises 5-hydroxyflavone, acetylhydroxyproline, and a suitable solvent. This composition is a unique vesicular composition that enables efficient delivery and synergistic effects of the two active ingredients. It promotes autophagy, has improved solubility, stability, and antioxidant properties, and can prevent and repair skin photodamage at its source. This invention also discloses a method for preparing this composition and its applications.

The present invention provides a salt of an aromatic amino purine derivative shown in Formula 2, and a preparation method and application thereof. The salt obtained by the present invention has good crystallinity and significantly improved solubility relative to the free form. The salt and the crystal form preferably have low hygroscopicity and can exist stably, so it is easier to make medicine than the free form of aromatic amino purine derivatives or other salts. (2).

This invention relates to isolated polypeptides that are analogs of human amylin. The disclosed amylin analog polypeptides have beneficial physicochemical properties relative to endogenous amylin, such as longer elimination half-lives (t1 / 2) and improved solubility and thermal stability. This invention also relates to methods of using presently disclosed amylin analog polypeptides in a variety of therapeutic indications, as well as methods of producing the same. The disclosed amylin analog polypeptides are particularly useful in methods of treating metabolic diseases or disorders, such as types 1 and 2 diabetes, and providing weight loss.

The present invention relates to a use of a methylated peptide as a therapeutic agent for degenerative brain diseases. Specifically, it has been confirmed that the methylated peptide according to the present invention exhibits improved solubility, bioavailability, phagocytosis by microglia, and anti-inflammatory efficacy compared to a conventional unmodified peptide, and exhibits excellent amyloid beta reduction efficacy compared to a conventional unmodified peptide in an animal model of degenerative brain diseases. Therefore, the methylated peptide according to the present invention can be usefully used as an active ingredient of a composition for preventing or treating degenerative brain diseases and cognitive impairment, learning disability, or memory impairment associated therewith.

Provided herein are compositions comprising a silicate, inositol, and optionally an amino acid, which have improved solubility and / or are crystalline. Also provided are methods of making the disclosed compositions, as well as methods of making beverages comprising the disclosed compositions.

Provided are substrates and methods for detecting enzymatic activity of various lysosomal storage enzymes. The molecules may be used as substrates with improved solubility.

The subject matter of the present invention is a creatine agglomerate with improved solubility characteristics in aqueous systems and improved handling, thus simplifying the intake of creatine. The agglomerate is characterized in that it contains 30 to 99.9 wt. % of ground creatine and / or ground creatine derivatives and / or ground creatine salts and 0.1 to 30 wt. % of a binder containing at least one oligosaccharide, in particular maltodextrin, based on the total weight of the agglomerate.

The present application belongs to the technical field of biological medicine, and discloses a salinomycin derivative, and a preparation method therefor and a use thereof. The salinomycin derivative comprises a general formula structure of formula (1), and compared with salinomycin, the activity of the salinomycin derivative is significantly improved. A group at the C-20 position contains a disulfide bond. By means of a replacement reaction of the disulfide bond, quick and efficient coupling with a polypeptide or an antibody can occur to obtain a GSH-sensitive salinomycin derivative containing the polypeptide or the antibody, or a salt thereof. The salinomycin derivative containing the polypeptide or the antibody, or the salt thereof has improved solubility, and also has enhanced targeting performance, has improved drug selectivity and biological activity, has a bystander effect, and in addition to being able to kill tumor cells highly expressing antigens, has a significant inhibitory effect on cells lowly expressing antigens. In addition, the salinomycin derivative or the salt thereof has the effects of reversing drug resistance in tumor cells and enhancing drug sensitization and can be used in combination with other drugs to further improve the efficacy.

The present application relates to ursolic acid with improved solubility and dispersibility, a method for producing same, and a method for improving the solubility of ursolic acid. In the present application, a complex of ursolic acid, an emulsifier, and a nonionic surfactant is formed and made into microparticles, thereby improving the solubility and dispersibility of poorly soluble ursolic acid and facilitating the utilization of ursolic acid as a nutritional material.

To provide glucose-dependent insulinotropic peptide (GIP)-derived peptide analogues which are antagonists of the GIP receptor.SOLUTION: The invention provides GIP-derived peptide analogues having specific sequences. The GIP peptide analogues are optimized by comprising amino acid substitutions A13Aib and / or N24E, and are fatty acid conjugated with / without a linker, thereby having improved solubility and / or physical stability.SELECTED DRAWING: None

Exemplary embodiments of the present technological advancement include pyridine-2,6-bis(phenylenephenolate) complexes that are useful as catalyst components for olefin polymerization and have enhanced solubility in non-aromatic hydrocarbons (e.g., isohexane). The improved solubility of these complexes was accomplished by the modification of the leaving group which generally leads to improved solubility, without adversely affecting the performance of the complex when used as a catalyst for olefin polymerizations.

The present disclosure provides cyclodextrin inclusion complexes of a β-cyclodextrin substituted host molecule wherein the guest is tirapazamine. The molar ratio of the tirapazamine guest to the cyclodextrin host ranges from about 14:1 to about 2:1, inclusive. The complexed tirapazamine has advantageous properties when compared to non-complexed tirapazamine in that the tirapazamine complex is water soluble and, at a molar ratio of the β-cyclodextrin substituted host molecule to the tirapazamine guest of 2:1, the pH of a 0.7-1 mg / mL solution of the inclusion complexes containing tirapazamine ranges from about pH 5.3 to about pH 6.4. The present disclosure also provides pharmaceutical compositions comprising a pharmaceutically acceptable carrier and cyclodextrin inclusion complexes of β-cyclodextrin substituted host molecules wherein the guest is tirapazamine. The pharmaceutical composition comprising the β-cyclodextrin-complexed tirapazamine demonstrates improved stability, improved solubility and reduced toxicity of the tirapazamine compared to non-complexed tirapazamine alone.

The present invention provides a crystal of a compound of formula I as a 3-hydroxy-5-pregnane-20-one derivative and a preparation method thereof. Specifically, the invention provides a crystal form G of a compound shown as a formula I and a preparation method thereof. The crystal form G of the present invention has significantly improved solubility, excellent storage stability at various temperatures, and low hygroscopicity, thereby improving druggability, and bringing very excellent effects for production, sales and transportation of drugs.

The present invention relates to a method for producing a plant protein extract comprising providing an aqueous suspension of a plant protein composition acidified to its isoelectric pH, adding an alkaline composition comprising a carbonate or bicarbonate salt to said suspension to correct the pH of said suspension to a pH ranging from 6.2 to 7.0, preferably 6.40 to 6.70, and heat treating the suspension at the corrected pH to form the plant protein extract. The invention also relates to a pea protein extract with a solubility, determined at 20°C and at pH 7, of greater than or equal to 50% and also with a reduced sodium content, and also to the use thereof for producing food products, in particular beverages.

A cyclocurcumin-based composition consisting of: a cyclocurcumin component present at 20 to 40 wt% of the total composition; a curcuminoid component present at 30 to 50 wt%, comprising 20 to 30 wt% curcumin, 5 to 10 wt% demethoxycurcumin, and 3 to 8 wt% bisdemethoxycurcumin; a solubilizer component present at 5 to 15 wt%, comprising polysorbate at 3 to 8 wt% and lecithin at 3 to 7 wt%; a complexing component present at 5 to 12 wt%, comprising cyclodextrin inclusion complexes; and a nanoparticulate component present at 3 to 10 wt%, comprising cyclocurcumin particles with a particle size in the range of 50 nm to 200 nm. consists of a polymer stabilizing component, which is present in an amount of 4 to 10 wt.-% is present and comprises polyvinylpyrrolidone or polyethylene glycol, a phospholipid complex component present in an amount of 3 to 8 wt% and consisting of phosphatidylcholine complexes, and an encapsulation component present in an amount of 2 to 6 wt% and containing maltodextrin or gum arabic, the composition being configured to ensure improved solubility, stability and bioavailability.

This invention provides urolithin A cocrystals, their preparation methods, compositions, and applications. Specifically, this invention provides a urolithin A cocrystal with high bioavailability, wherein the urolithin A cocrystal is selected from the group consisting of: urolithin A-proline cocrystals, urolithin A-carnitine cocrystals, urolithin A-nicotinamide cocrystals, or urolithin A-creatine cocrystals. Compared to urolithin itself, the urolithin A cocrystals of this invention exhibit high stability, a significantly lower melting point, and significantly improved solubility and bioavailability. Furthermore, the preparation method is simple, easy to control, and has good reproducibility, allowing for stable acquisition of the target cocrystal. The composition containing the cocrystal, prepared by grinding, has high yield, low cost, and is suitable for large-scale production.

The present invention relates to the field of pharmaceutical crystal forms, and specifically relates to crystal forms of 2-(4,4-difluoroazepin-1-yl)-N-(2-sulfamoylpyridin-4-yl)quinoline-3-carboxamide and a salt thereof, a pharmaceutical composition, and a use. The crystal forms of a compound of formula (I) and a salt thereof which are obtained in the present invention have excellent physical stability and chemical stability, and compared with free base crystal form K1 of the compound of formula (I), have significantly improved solubility, hygroscopicity and bioavailability, and are more conducive to clinical applications. Also disclosed in the present invention is a use of the crystal forms of the compound of formula (I) and the salt thereof as sodium ion channel Nav1.8 inhibitors for treating a wide range of pain.

The invention provides a reactive curing agent which has improved solubility in methyl ethyl ketone and can improve the heat resistance of a thermosetting resin composition. According to the present invention, provided is a reactive curing agent comprising a copolymer containing an aromatic vinyl monomer unit, an unsaturated acid anhydride monomer unit, and a maleimide monomer unit, the weight-average molecular weight of the copolymer being 10,000 or more and less than 9,000, and the total content of the monomer units contained in the copolymer being 100% by mass. The copolymer contains the maleimide monomer unit in an amount of 3.0% by mass or more but less than 49.0% by mass.

Exemplary embodiments of the industrial progress of the present invention include pyridine-2,6-bis(phenylene phenolate) complexes that are useful as catalyst components for olefin polymerization and have improved solubility in non-aromatic hydrocarbons (e.g., isohexane). The improvement in the solubility of these complexes was achieved by modifying the ligand framework that provides improved solubility at specific positions, but did not adversely affect the performance of this complex when used as a catalyst for olefin polymerization.

The invention relates to the technical field of medical chemistry, and discloses a compound PX5-9 with neuroprotective activity as well as a preparation method and application thereof. The compound PX5-9 is obtained by introducing an N-Oxide group on the basis of the structure of a compound 5, and has remarkable neuroprotective activity, improved solubility and equivalent biological activity. The compound PX5-9 is used for preparing drugs for treating central nervous system degenerative diseases or traumatic brain injury, such as Alzheimer's disease or Parkinson's disease, solves the problems of poor solubility and affected druggability of the compound 5, and has potential clinical application value.

Provided is a novel crystalline form of lifitegrast and a pharmaceutical composition containing the novel crystalline form of lifitegrast. The crystalline form of lifitegrast has improved solubility and excellent stability against heat and moisture, thereby being effectively used for preparing a pharmaceutical composition.

To provide a unit dose detergent article having improved solubility.SOLUTION: Provided is a multi-compartment water-soluble unit dose detergent article including a plurality of compartments in a generally superposed relationship. The water-soluble unit dose detergent article 1 includes a water-soluble film wrapping a fabric care or household care detergent composition. The detergent composition includes a detersive surfactant. The water-soluble film includes a first film 2 including a specific polyvinyl alcohol polymer blend.SELECTED DRAWING: Figure 1