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2446 results about "Hydroxypropylmethyl cellulose" patented technology

Hydroxypropyl methyl cellulose (HPMC) is a polymer used for multiple applications in fields such as construction and ophthalmology.

Controlled release formulations using intelligent polymers

InactiveUS6893661B1Promote absorptionMaintenance of therapeutically effective blood levelPowder deliveryOrganic active ingredientsSmart polymerWater contact
An extended release dosage composition of pharmaceutically active substances that have a water contact angle (θ) such that cos θ is between +0.9848 and −0.9848 presented as a matrix tablet containing the said pharmaceutically active substances, with/without suitable pharmaceutical excipients in intimate mixture with two groups of intelligent polymers having opposing wettability characteristics, one demonstrating a stronger tendency towards hydrophobicity and the other a stronger tendency towards hydrophilicity, the polymer combination being between the ratios of 1:50 and 50:1 amounts effective to control the release of said pharmaceutically active substances in a mathematically predictable manner, wherein the polymer demonstrating a stronger tendency towards hydrophobicity is not less than 5% wt/wt and preferably between 5-70% wt/wt of the final formulation composition. The intelligent polymers being ethylcellulose (EC) as a more strongly hydrophobic and hydroxyethylcellulose (HEC) and/or hydroxypropyl methylcellulose (HPMC) as more strongly hydrophilic (the ratio of HEC to HPMC being between 1:100 and 100:1). The matrix tablet is optionally coated with an enteric coat, 0-5%-15% wt/wt to prevent the initial burst effect seen in such systems and to impart gastrointestinal tract (GIT) “stealth” characteristics especially in the presence of food.
Owner:VALEANT INT BERMUDA

Stabilized Hme Composition With Small Drug Particles

A hot-melt extruded composition having finely divided drug-containing particles dispersed within a polymeric and/or lipophyllic carrier matrix is provided. The carrier softens or melts during hot-melt extrusion but it does not dissolve the drug-containing particles during extrusion. As a result, a majority or at least 90% wt. of the drug-containing particles in the extrudate are deaggregated during extrusion into essentially primary crystalline and/or amorphous particles. PEO is a suitable carrier material for drugs insoluble in the solid state in this carrier. Various functional excipients can be included in the carrier system to stabilize the particle size and physical state of the drug substance in either a crystalline and/or amorphous state. The carrier system is comprised of at least one thermal binder, and may also contain various functional excipients, such as: super-disintegrants, antioxidants, surfactants, wetting agents, stabilizing agents, retardants, or similar functional excipients. A hydrophilic polymer, such as hydroxypropyl methylcellulose (HPMC E15), polyvinyl alcohol (PVA), or poloxamer, and/or a surfactant, such as sodium lauryl sulfate (SLS), can be included in the composition. A process for preparing the extrudate is conducted at a temperature approximating or above the softening or melting temperature of the matrix and below the point of solubilization of drug-containing particles in the carrier system, and below the recrystallization point in the case of amorphous fine drug particles.
Owner:BOARD OF RGT THE UNIV OF TEXAS SYST

Sustained release formulations of guaifenesin and additional drug ingredients

The invention relates to a novel pharmaceutical sustained release formulation of guaifenesin and at least one additional drug ingredient. The formulation may comprise a hydrophilic polymer, preferably a hydroxypropyl methylcellulose, and a water-insoluble polymer, preferably an acrylic resin, in a ratio range of about one-to-one (1:1) to about nine-to-one (9:1), more preferably a range of about three-to-two (3:2) to about six-to-one (6:1), and most preferably in a range of about two-to-one (2:1) to about four-to-one (4:1) by weight. This formulation capable of providing therapeutically effective bioavailability of guaifenesin for at least twelve hours after dosing in a human subject. The invention also relates to a modified release product which has two portions: a first portion having an immediate release formulation of guaifenesin and a second portion having a sustained release formulation of guaifenesin, wherein one or both portions has at least one additional drug ingredient. The modified release product has a maximum guaifenesin serum concentration equivalent to that of an immediate release guaifenesin tablet, and is capable of providing therapeutically effective bioavailability of guaifenesin for at least twelve hours after dosing in a human subject.
Owner:RB HEALTH US LLC

Slowly-released compound acidifier for poultry and livestock feed, preparation method thereof and feed

The invention discloses a slowly-released compound acidifier for poultry and livestock feed, a preparation method thereof and feed containing the same. The compound acidifier comprises the following compositions in part by weight: 30 to 80 parts of complex organic acid, 15 to 50 parts of supplementary materials and 5 to 20 parts of coating agents. The complex organic acid is citric acid, fumaric acid, malic acid, lactic acid, linoleic acid, crataegolic acid, ursolic acid, chlorogenic acid, glycyrrhizic acid and oleanolic acid, and the supplementary materials are silicon dioxide, hydroxypropyl methylcellulose and ethyl cellulose. The acidifier is scientifically proportioned, has strong efficiency and is long-acting and slow-releasing, nutrients in the feed are free from being damaged, the acidifier has good fluidity and is easy to be uniformly mixed with the feed, the digestive absorption of nutrients can be promoted, the conversion rate of the feed can be improved, the productivity of poultry and livestock can be improved, the time for domestic animals for sale can be effectively shortened, the health of gastrointestinal mucosa of the animals can be protected, the immunologic function of the animals can be strengthened, and diseases can be prevented.
Owner:BEIJING DABEINONG ANIMAL HEALTH TECH +1

External wall flexible waterproof putty powder and preparation method thereof

The invention relates to external wall flexible waterproof putty powder and a preparation method thereof. The flexible waterproof putty powder consists of the following components according to weight percentage: 22% of cement, 20.5% of heavy calcium carbonate, 15% of quartz powder, 8% of diatomite, 8% of talcum powder, 5% of kaolin, 5% of ash calcium, 3% of ethylene oxide, 2% of a retarder, 0.3% of HPMC, 3% of latex powder, 2% of wollastonite powder, 2% of a catalyst, 0.4% of a dehydrating agent, 0.5% of wood fiber, 0.3% of starch ether and 3% of other fillers, wherein the particle size of the heavy calcium carbonate powder is controlled as follows: d97 is smaller than 10 microns, d50 is 1.5 microns, the whiteness is greater than 95%, and the CaCO3 content is greater than or equal to 98%; the quartz powder with 1-3 microns accounts for 57%, 5-8 microns for 22%, 9-15 microns for 13%, and 15-18 microns for 8%; the diatomite is 260-300 mesh; for kaolin, d97 is about 15 microns, d50 is about 2 microns, and the whiteness is greater than 92%; the retarder includes 72% of a citric acid retarder and 28% of a sodium polyphosphate retarder; the length-diameter ratio of wollastonite powder is greater than 10; HPMC adopts hydroxypropyl methyl cellulose with the viscosity of 100,000. The external wall flexible waterproof putty powder has the characteristics of being white, fine and smooth, good in construction workability, high in strength, good in water resistance and anti-cracking.
Owner:杭州正博新型建筑材料有限公司

Moisture-absorbing and perspiring anti-bacterial fabric and preparation technology thereof

The invention relates to a moisture-absorbing and perspiring anti-bacterial fabric and a preparation technology thereof. The moisture-absorbing and perspiring anti-bacterial fabric is blended and weaved by the following raw materials in parts by weight: 40 to 80 parts of bamboo fibers, 40 to 80 parts of long staple, 10 to 30 parts of ramie, 10 to 30 parts of coolmax fibers, 10 to 20 parts of corn fibers, 10 to 20 parts of Delight fibers, and 5 to 20 parts of Tancel, and then is treated by anti-bacterial finishing liquid; the anti-bacterial finishing liquid comprises 5 to 10 parts of chitosan, 5 to 10 parts of silk fibroin, 0.5 to 3 parts of butyl ricinoleate sodium sulfate, 0.5 to 3 parts of lemon acid, 0.5 to 2 parts of butyl methacrylate, 5 to 8 parts of dodecyl diphenyl ether sodium disulfonate, 5 to 10 parts of hydroxypropyl methyl cellulose, 5 to 10 parts of polyhexamethylene biguanidine, 5 to 15 parts of organosilicon quaternary ammonium salt, 3 to 8 parts of dodecyl trimethyl ammonium chloride, and 5 to 10 parts of water-based polyurethane. The moisture-absorbing and perspiring anti-bacterial fabric has the advantages that the anti-bacterial property is higher, the moisture-absorbing, perspiring, anti-pilling and air-ventilation properties are realized, the softness is realized, and the abrasion is resisted; the moisture-absorbing and perspiring anti-bacterial fabric is particularly suitable for being applied to the fields of underwear, overwear, sportswear and bedding articles.
Owner:杜名胜

Tea polyphenol liposoluble microcapsules and preparation method thereof

The invention relates to microcapsules and a preparation method thereof, particularly to tea polyphenol liposoluble microcapsules and a preparation method thereof, wherein a core material of the tea polyphenol liposoluble microcapsules comprises tea polyphenol and reduced glutathione, a mass ratio of the tea polyphenol to the reduced glutathione is 95-99:1-5, a wall material of the tea polyphenol liposoluble microcapsules is one or a plurality of materials selected from arabic gum, dextrin, corn syrup, ethyl cellulose, methylcellulose, and hydroxypropyl methylcellulose phthalate, and a mass weight ratio of the core material to the wall material is 1:1-4. The tea polyphenol liposoluble microcapsule preparation method comprises the following steps: respectively preparing a core material emulsion liquid and a wall material solution, adding the core material emulsion liquid to the wall material solution, carrying out high speed stirring, homogenizing, and carrying out spray drying to obtain the tea polyphenol liposoluble microcapsules. The tea polyphenol liposoluble microcapsules have characteristics of fine average particle size and slow tea polyphenol release, such that anti-oxidation and absorption utilization efficiency of the tea polyphenol are substantially improved.
Owner:ZHEJIANG MINGHUANG NATURAL PRODS DEV

Preparation method of high-strength and antioxidant rare-earth-based smoke denitration catalyst

The invention discloses a preparation method of a high-strength and antioxidant rare-earth-based smoke denitration catalyst. The preparation method of the high-strength and antioxidant rare-earth-based smoke denitration catalyst comprises the following steps: by taking titanium dioxide and montmorillonite as carriers and ammonium metatungstate, cerous nitrate and lanthanum nitrate as active components, mixing, ageing, kneading, forming, drying and roasting with the accompanying of auxiliary materials. The auxiliary materials comprise ammonia water, lactic acid, citric acid, stearic acid, glass fiber, wood pulp, hydroxypropyl methyl cellulose, polyoxyethylene, monoethanolamine and water. The product prepared by the method is separated under a high SO2 smoke condition, nitric oxide in the smoke can be decomposed; meanwhile, the purpose of removing mercury and dioxin can be achieved. According to the preparation method of the high-strength and antioxidant rare-earth-based smoke denitration catalyst, the rare earth elements, namely cerium and lanthanum are used as the active components, so that the addition amount of vanadium is reduced, the toxicity of the product is reduced or the product is non-toxic product, the pressure of the post treatment of the product is reduced; the environmental protection pressure is reduced; the product is environmentally friendly; the product can be widely used in the field of thermal power plants, glass factories and chemical plants.
Owner:山东信义汽车配件制造有限公司
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