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71 results about "Smart polymer" patented technology

Smart polymers or stimuli-responsive polymers are high-performance polymers that change according to the environment they are in. Such materials can be sensitive to a number of factors, such as temperature, humidity, pH, chemical compounds , the wavelength or intensity of light or an electrical or magnetic field and can respond in various ways, like altering colour or transparency, becoming conductive or permeable to water or changing shape (shape memory polymers). Usually, slight changes in the environment are sufficient to induce large changes in the polymer's properties.

Water-dispersible oral, parenteral, and topical formulations for poorly water soluble drugs using smart polymeric nanoparticles

Polymeric nanoparticles with a hydrophobic core and a hydrophilic shell are formed from: 1) N-isopropyl acrylamide (NIPAAM), at a molar ratio of about 50% to about 90%, and preferably 60% for specific delivery routes such as oral or parenteral; either water-soluble vinyl derivatives like vinylpyrolidone (VP) or vinyl acetate (VA), or water insoluble vinyl derivatives like methyl methacrylate (MMA) or styrene (ST), at a molar ratio of about 10% to about 30%; and acrylic acid (AA), at a molar ratio of about 10% to about 30%. The formed nanoparticles may be optionally surface functionalized using reactive groups present in AA, including PEGylation, or conjugation of moieties such as chemotherapeutics, contrasting agents, antibodies, radionucleides, ligands, and sugars, for diagnostic, therapeutic, and imaging purposes. The polymeric nanoparticles are preferably dispersed in aqueous solutions. The polymeric nanoparticles incorporate one or more types of medicines or bioactive agents in the hydrophobic core; on occasion, the medicine or bioactive agent may be conjugated to the nanoparticle surface via reactive functional groups. The polymeric nanoparticles are capable of delivering the said medicines or bioactive agents through oral, parenteral, or topical routes. The polymeric nanoparticles allow poorly water soluble medicines or bioactive agents, or those with poor oral bioavailability, to be formulated in an aqueous solution, and enable their convenient delivery into the systemic circulation.
Owner:THE JOHN HOPKINS UNIV SCHOOL OF MEDICINE

Controlled release formulations using intelligent polymers

InactiveUS6893661B1Promote absorptionMaintenance of therapeutically effective blood levelPowder deliveryOrganic active ingredientsSmart polymerWater contact
An extended release dosage composition of pharmaceutically active substances that have a water contact angle (θ) such that cos θ is between +0.9848 and −0.9848 presented as a matrix tablet containing the said pharmaceutically active substances, with/without suitable pharmaceutical excipients in intimate mixture with two groups of intelligent polymers having opposing wettability characteristics, one demonstrating a stronger tendency towards hydrophobicity and the other a stronger tendency towards hydrophilicity, the polymer combination being between the ratios of 1:50 and 50:1 amounts effective to control the release of said pharmaceutically active substances in a mathematically predictable manner, wherein the polymer demonstrating a stronger tendency towards hydrophobicity is not less than 5% wt/wt and preferably between 5-70% wt/wt of the final formulation composition. The intelligent polymers being ethylcellulose (EC) as a more strongly hydrophobic and hydroxyethylcellulose (HEC) and/or hydroxypropyl methylcellulose (HPMC) as more strongly hydrophilic (the ratio of HEC to HPMC being between 1:100 and 100:1). The matrix tablet is optionally coated with an enteric coat, 0-5%-15% wt/wt to prevent the initial burst effect seen in such systems and to impart gastrointestinal tract (GIT) “stealth” characteristics especially in the presence of food.
Owner:VALEANT INT BERMUDA

Temperature and pH stimuli-responsive intelligent polymer microcapsule and preparation thereof

The invention relates to a temperature and pH stimuli-responsive intelligent polymer microcapsule and preparation thereof. The microcapsule comprises two polymers sensitive to temperature and pH, and an interpenetrating network structure is formed between the two polymers. Preparation includes the following steps: (1) uniformly blending tetraethyl orthosilicate, aqueous ammonia, water and absolute ethyl alcohol, and then adding surface modifier; (2) adding temperature-sensitive monomer and crosslinking agent into the modified dispersion, and adding initiator for reaction; (3) after diluting the emulsion by five to fifteen times, adding pH-sensitive monomer and crosslinking agent, and adding initiator for reaction; and (4) dispersing the white emulsion of core-shell composite particles with shells formed into a interpenetrating polymer network structure into hydrofluoric acid, and carrying out centrifugal separation or dialysis purification. The microcapsule can respectively respond tothe stimulation of temperature and pH, and moreover, the two types of stimuli responsiveness are independent from each other, and therefore have little interference on each other. The preparation method is simple, and is suitable for industrial production.
Owner:DONGHUA UNIV

Polymer nanometer blocking agent for water-based drilling fluid and its preparation method

InactiveCN107915798ARealize bridging and blockingRealize compression deformation sealingDrilling compositionWater basedTemperature response
The invention discloses a polymer nanometer blocking agent for water-based drilling fluid and its preparation method, and belongs to the technical field of a drilling fluid function material. The polymer nanometer blocking agent for water-based drilling fluid is prepared from, by weight, 4-16 parts of emulgator, 2-14 parts of temperature sensitive monomer, 10-53 parts of hydrophilic monomer, 0.5-10 parts of hydrophobic monomer and 0.05-0.5 part of initiator. The polymer nanometer blocking agent is small in size, and can block micro and nano-sized holes of a shale well wall; through compressivedeformation property of the poymer, the compact blocking of the well wall hole can be realized; by means of the temperature response property of an intelligent polymer, the transformation from hydrophilia to hydrophobicity is realized in the well wall, and the zone closing to the well wall is transformed to be a hydrophobic environment, thus the diffusion and permeation of water in the water-based dirlling fluid towards the shale well wall is effectively stopped, thereby stabilizing the well wall and protecting reservoir, and providing an important technical guarantee for the development of the water-based drilling fluid system for shale development.
Owner:SOUTHWEST PETROLEUM UNIV

Intelligent high-safety lithium-on battery with polymer skeleton

The invention discloses an intelligent high-safety lithium-on battery with a polymer skeleton. The intelligent high-safety lithium-on battery comprises a positive electrode, a negative electrode, a membrane and an electrolyte, wherein the positive electrode, the negative electrode and the membrane all contain positive-temperature temperature-sensitive polymer particles; the lithium-on battery can be reversibly converted between a ''liquid lithium-on battery'' and a ''polymer lithium-on battery'' within different temperature ranges; the electrolyte in the ''liquid lithium-on battery'' exists in a form of a liquid electrolyte; and the electrolyte in the ''polymer lithium-on battery'' exists in a form of a polymer electrolyte. The lithium-on battery disclosed by the invention is quickly converted into the ''polymer lithium-on battery'' when the temperature suddenly rises, and does not contain the liquid electrolyte, so that an unstable solid-liquid interface can be removed and the interface stability of the battery can be effectively improved; and by adopting the polymer skeleton, the positive electrode, the negative electrode and the membrane of the battery are tightly connected, and the stability of the battery structure can be improved, so that the lithium-on battery can show good cycling stability and excellent electrochemical properties at different temperatures and is suitable for various complicated environments.
Owner:SHANGHAI AEROSPACE POWER TECH
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