Controlled release formulations using intelligent polymers
a technology of intelligent polymers and formulations, applied in the field of controlled release formulations, can solve the problems of affecting the efficacy of osmotic and press coated tablets, the active ingredient is often not delivered in a consistent and reproducible manner, and the production cost is particularly high, so as to maintain the therapeutically effective blood level and good absorbability of the selected active ingredient.
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example 1
ER 5 mg
[0047]
% compositionGlipizide1.83Hydroxypropyl methylcellulose20Ethylcellulose16.17Hydroxyethylcellulose4Lactose30Microcrystalline cellulose23Silicone dioxide0.6Sodium Lauryl sulfate4Magnesium stearate0.4
example 2
Hydrochloride ER 60 mg
[0048]
% compositionDiltiazem hydrochloride58.82Hydroxypropyl methylcellulose5Ethylcellulose5Hydroxyethylcellulose15Lactose5Microcrystalline cellulose9.18Talc1Magnesium stearate1
example 3
e ER 60 mg
[0049]
% compositionNifedipine20Hydroxypropyl methylcellulose20Ethylcellulose29Hydroxyethylcellulose3.8Lactose14Microcrystalline cellulose10Silicone dioxide1.2Na lauryl sulfate1Magnesium stearate1
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