100 results about "Coated tablets" patented technology

The present disclosure is directed to oral tablet of ribociclib including its salt(s). One embodiment of the present disclosure is directed to tablet of ribociclib with high drug load with an immediate release profile. One embodiment of the present disclosure is directed to coated tablet of ribociclib. Another embodiment of the present disclosure is directed to coated tablet of ribociclib where the coating is an aqueous moisture barrier coating (e.g., Opadry® amb II coating where the coating is PVA based).

The present invention provides a tablet and a method for manufacturing a tablet that allows for easy formulation of coated tablets, even when calcium carbonate is used for coating the tablet. [Solution] A tablet coated with a coating layer, wherein the coating layer comprises calcium carbonate granules and a binder for binding the calcium carbonate granules together. The invention also provides a method for manufacturing a tablet coated with a coating layer, comprising a raw material preparation step of dispersing calcium carbonate granules and a binder for binding the calcium carbonate granules together in an aqueous medium to obtain a coating raw material, and a coating layer formation step of coating a tablet with the coating raw material.

The invention addresses the instability and toxicity of organometallic compounds used as fuel additives, which can pose environmental and health risks during handling. While these additives improve fuel combustion, efficiency, and reduce emissions by increasing octane, their handling exposes humans and the environment. This invention provides a formulation, coating process (spraying, immersion, extrusion, powder coating), and testing method to prevent direct contact. Coatings, comprising organic hydrocarbons, do not hinder octane enhancement, ensure deposit-free release in fuel tanks, and clean the fuel system. The coating also prevents sublimation during storage. Performance is evaluated by measuring weight loss under vacuum.

The invention discloses a mixed auxiliary material for traditional Chinese medicine film coated tablets and a preparation method of the mixed auxiliary material. The mixed auxiliary material comprises the following components in percentage by weight: 50-60% of etherified crosslinked starch, 15-20% of pregelatinized starch, 10-15% of sodium carboxymethyl starch, 0.6-0.8% of magnesium stearate and 2-3% of talc. The etherified cross-linked starch is used for replacing a traditional polymer, a cross-linked structure of the etherified cross-linked starch blocks water molecule permeation, pre-gelatinized starch improves powder fluidity, crushed talcum powder is mixed with the pre-gelatinized starch, microgaps are filled, a friction system is reduced, and the situation that the sheet surface is rough and prone to sticking is avoided; the dynamic balance of sodium carboxymethyl starch and magnesium stearate ensures the synergism of disintegration and lubrication, and completely avoids the problems of poor tablet hardness, slow disintegration and large weight difference of traditional Chinese medicine film-coated tablets.

A gastro-resistant high-strength unit dosage form includes a solid solution prepared by hot-melt extrusion, whereby the solid solution contains 300 mg posaconazole and an enteric polymer in a specific weight ratio. The unit dosage form may be a capsule or an optionally film-coated tablet.

The invention belongs to the technical field of proton pump inhibition medicine preparations, and relates to a rabeprazole sodium enteric-coated tablet and a preparation method thereof. The technical problems that an existing rabeprazole sodium enteric-coated tablet is insufficient in stability, lagged in dissolution and the like are solved. The enteric-coated tablet consists of a tablet core and an enteric-coated coating layer wrapped outside the tablet core, wherein the tablet core comprises auxiliary materials such as rabeprazole sodium, a filling agent, an adhesive, a stable dissolution promoter and the like; the enteric coating layer comprises an enteric coating material, a plasticizer, an anti-sticking agent and a solvent. Through the synergistic effect of the compound stabilizer and process control, the stability and dissolution performance of the enteric-coated tablet are synergistically improved, meanwhile, the production process is simplified, and the preparation method is suitable for industrial application.

The present invention belongs to the technical field of pharmaceutical formulations, specifically relates to a controlled-release tablet of loxoprofen sodium, its preparation method, and use. The controlled-release tablet comprises a drug-containing immediate-release layer, a drug-containing core layer, and a drug-containing sustained-release layer, the drug-containing core layer comprising a plain tablet core, an enteric coating film, and a sealing coating film. The preparation method includes granulating the raw materials for the drug-containing immediate-release layer and the drug-containing sustained-release layer, respectively, wet granulating the raw materials for the plain tablet core and compressing them into tablets, followed by sequentially applying a first sealing coating, a second enteric coating, and a third sealing coating to obtain a drug-containing core, placing the drug-containing core on the drug-containing sustained-release layer granules and pre-compressing them, and then placing the drug-containing immediate-release layer granules on the pre-compressed tablet, compressing them, and coating them to obtain the drug-containing core. The present invention achieves the sustained-release effect of the loxoprofen sodium tablet core by designing the single-layer structure, raw materials, and coating layer components of the dry-coated tablet, thereby achieving 12-hour in vivo efficacy and improving patient compliance.

The utility model relates to the technical field of health care product preparation devices, in particular to a health care tablet coating device which comprises an equipment box body, a feeding port is formed in the right end of the equipment box body, and a coating module is arranged in the equipment box body. The coating module comprises a transmission plate, a supporting rod, a supporting ring, a positioning groove, a coating roller, a fixing ring, a positioning sliding block, a spraying pipe and an air inlet pipe, an inserting hole is formed in the center of the transmission plate, a driving module is arranged on the left side of the equipment box body, and the driving module comprises a first positioning ring, a servo motor, a transmission gear, a second positioning ring and a transmission gear ring. One group of coating rollers is fed into the equipment box body, the other group of coating rollers are fed into the equipment box body, then the tablets coated in the previous group of coating rollers are taken out, and the inner walls of the coating rollers are cleaned, so that the cleanliness of the interiors of the coating rollers is effectively kept, the coating quality is improved, and meanwhile, the multiple groups of coating rollers are matched, so that the coating efficiency is improved. The feeding and discharging time is shortened, and the coating efficiency is improved.

The invention provides a bromocriptine mesylate enteric-coated tablet and a preparation method thereof. Specifically, the bromocriptine mesylate enteric-coated tablet comprises a tablet core and an enteric coating layer wrapping the tablet core. The enteric-coated tablet disclosed by the invention is simple in process, good in stability and small in gastrointestinal side effect, the bioavailability of the enteric-coated tablet is more than two times that of a common tablet sold in the market, the dosage is expected to be reduced, the side effect is further reduced, and the enteric-coated tablet has excellent clinical value.

1. The name of the design product: packaging box (omeprazole enteric-coated tablets). 2. The use of the design product: used for the outer packaging of products. 3. The design points of the design product: the combination of shape and pattern. 4. The picture or photo that best indicates the design points: the unfolded state reference drawing.

The invention discloses a rifapentine isoniazide tablet and a preparation method thereof, the rifapentine isoniazide tablet is a core-coated tablet, and comprises an inner-layer tablet core containing rifapentine and an outer-layer tablet layer containing isoniazide; the inner-layer tablet core comprises rifapentine, edetate disodium, sodium ascorbate and lauryl sodium sulfate, the rifapentine accounts for 53-63% of the total mass of the inner-layer tablet core, and the rifapentine tablet further comprises a filler, a stabilizer, a disintegrating agent, an adhesive, a surfactant, a lubricant and a coating layer; the coating layer coats the inner-layer tablet core; the outer sheet layer comprises isoniazide, a filling agent, a disintegrating agent, an adhesive, a lubricant and an adhesive; and the mass of the isoniazide accounts for 75-95% of the total mass of the outer sheet layer. According to the rifapentine isoniazide tablet disclosed by the invention, the compliance of a patient is enhanced. And meanwhile, the potential safety hazard problem of impurity increase caused by incompatibility of rifapentine and isoniazide is solved.

This application discloses a jujube seed and Ganoderma lucidum film-coated tablet and its preparation method. The film-coated tablet uses jujube seed and Ganoderma lucidum in a weight ratio of (2.9–3.1):2 as active raw materials, employs a microcrystalline cellulose and erythritol compound as fillers, and combines them with silica, magnesium stearate, and a specific composite film-coating agent. The preparation method includes raw material pretreatment, water extraction, vacuum concentration, vacuum drying, fluidized bed granulation, total mixing and tableting, and film coating, optimizing each process parameter. This application solves the technical problems of existing traditional Chinese medicine extracts, such as high hygroscopicity, poor compressibility, poor stability, and unclear synergistic effects. The prepared product has high active ingredient content, good stability, rapid disintegration, and good patient compliance, making it suitable for large-scale industrial production and possessing good market application prospects.

This utility model relates to the technical field of coating devices, specifically a coating device for the enteric coating layer of bisacodyl enteric-coated tablets. It includes a cabinet with a roller inside. A rotating ring is connected to the left side wall of the cabinet, and the left end of the rotating ring is rotatably connected to the inner left side wall of the cabinet via a bearing. In operation, bisacodyl tablets are placed into the roller, the door is closed, and a motor drives the drive wheel, transmission belt, driven wheel, rotating ring, and roller to rotate. Support rollers provide support and improve the stability of the roller's rotation. A peristaltic pump draws and delivers the coating solution to the nozzle of a spray gun. The spray gun is connected to a compressed air pipeline, and the compressed air is used to evenly spray the coating solution onto the surface of the bisacodyl tablets for coating. The rotation of the roller causes the tablets to continuously rotate, ensuring the uniformity of the coating solution spray, thereby effectively coating the surface of the bisacodyl tablets with an enteric coating layer.

The invention discloses an artemisia selengensis leaf extract self-microemulsifying drug delivery system and a preparation method thereof, and belongs to the technical field of pharmaceutical preparations. The system is composed of artemisia selengensis leaf extract and a self-microemulsion drug delivery system composed of an oil phase, a surfactant and a cosurfactant, and the mass ratio of the oil phase to the surfactant to the cosurfactant is (10-20): (60-80): (10-30). According to the invention, the liquid system is solidified into powder through an adsorption carrier, and the powder is further prepared into enteric-coated tablets. The drug delivery system can significantly improve the solubility, stability and intestinal absorption efficiency of caffeoylquinic acid compounds (CQAs) in the artemisia selengensis leaves, effectively inhibits degradation of the caffeoylquinic acid compounds in gastric juice, shows excellent xanthine oxidase inhibitory activity, can be used for preparing functional foods or drugs for reducing uric acid, and realizes high-valued utilization of artemisia selengensis leaf resources.

The invention relates to a coating method of a powerful anti-glare sugar-coated tablet. The coating method comprises the following steps: coating an isolating layer; coating a mixed slurry layer; coating a sugar coating layer; according to the preparation method disclosed by the invention, a novel mixed slurry coating method is adopted, the simple syrup and the talcum powder are prepared into mixed slurry, and the mixed slurry is uniformly dripped in a production process by using an automatic dripping method of a coating gun, so that the non-uniformity of manually scattering the talcum powder is reduced, the production operation is simple and convenient, the coating difficulty is reduced, and the operation error rate is reduced; the quality risk of an intermediate product is reduced, dust flying and pollution to the production environment in the production process are avoided, and the weight increment of the coating is reduced. According to the method, the use amount of talcum powder is only 1 / 2 of that of a traditional method, and the rejection rate of cut pieces is reduced to 2%-3% from 4%-5% of that of the original method.

The invention discloses a galanthamine hydrobromide enteric-coated tablet and a preparation method thereof. The tablet is composed of a tablet core, an isolation layer and an enteric layer, the tablet core contains 5.0%-16.0% of galanthamine hydrobromide, and auxiliary materials such as mannitol, a mixture of magnesium stearate and sodium stearyl fumarate in a specific proportion, colloidal silicon dioxide and the like are matched; the isolating layer adopts an opadry II type film coating, and the enteric-coated layer adopts an opadry Acryl-EZE II type enteric-coated coating. The dissolution rate of the tablet in an acidic medium with the pH value of 1.2 for 2 hours is less than 5%, the release rate of the tablet in a medium with the pH value of 5.5 or 6.8 for 45 minutes is more than or equal to 80%, the tablet is sealed and placed at 40 DEG C + / -2 DEG C / 75% + / -5% RH for 6 months, the stability is good, and the pharmacokinetic parameters are excellent. The preparation method comprises the steps of raw and auxiliary material pretreatment, graded premixing, total mixing and lubricating, tabletting, two-step coating and the like, and the process is stable and controllable. The enteric-coated tablet disclosed by the invention is strong in targeted release property, high in stability and good in bioavailability, and can guarantee the effectiveness and safety of medication.

The invention discloses an in-vitro dissolution method of a posaconazole enteric-coated tablet, which is characterized in that a Tween-80 (TWEEN-80) surfactant is added into a dissolution medium, so that the solubility of the posaconazole enteric-coated tablet in a phosphate buffer solution is remarkably improved, the phenomenon that a solution in a dissolution cup is not uniform is solved, the jump point phenomenon of a dissolution curve is eliminated, and the dissolution rate of the posaconazole enteric-coated tablet is improved. When a phosphate buffer solution added with a certain amount of surfactant is used as a dissolution medium, the accumulated dissolution amount at each time point is stable, the dissolution curve is smooth, the detection result is accurate and reliable, the repeatability and predictability of the dissolution test are remarkably improved, and a more reliable detection method is provided for the initial stage of drug research and development and quality control.

A coating composition useful for coating a tablet such as a tablet, a capsule, a pill, a capsule, a confection or a grain, the coating composition comprising an opaque amount of cross-linked povidone having an average particle size of less than 10 [mu] m. Crosslinked povidone having an average particle size of less than 10 [mu] m is used as an opacifier and white pigment in the coating of the coated tablet in place of titanium dioxide.

The invention discloses a progesterone enteric-coated tablet processing technology. The technology comprises the following steps: 1, preparing a tablet core; 2, coating an isolating layer; 3, coating an enteric-coated layer; and 4, coloring layer coating. According to the processing technology of the progesterone enteric-coated tablet, the overall technological steps, technological parameters in all the technological steps and the raw material formula are optimized, the steps are simple, operation is easy, the quality of all layers of coatings can be effectively controlled, the stability and consistency of the final product are ensured, the prepared progesterone enteric-coated tablet can stably release medicine in the intestinal tract, and the bioavailability of the product is improved. The absorption speed is high, and the medication comfort and compliance of a patient are improved, so that the requirements of clinical treatment are better met.

This application provides a pharmaceutical composition comprising: an active ingredient, a filler, a disintegrant, and optionally one or more of a binder, a flow aid, and a lubricant. It also provides an enteric-coated tablet comprising (1) a core containing the aforementioned pharmaceutical composition; (2) an optional insulating layer; and (3) an enteric coating layer. The active ingredient in the enteric-coated tablet is not released in the stomach but is released in the intestines, preventing the active ingredient in the composition from degrading in the acidic environment of the stomach.

The utility model provides an air heater for enteric-coated tablet coating production, which comprises an air supply mechanism, a heating mechanism and a temperature adjusting tank, and the air outlet end of the air supply mechanism is connected with the temperature adjusting tank through a first connecting pipe. The heating mechanism is connected with the gas outlet end of the gas supply mechanism through a second connecting pipe, the heating mechanism is connected with the temperature adjusting tank through a third connecting pipe, and a gas distribution mechanism is installed on the temperature adjusting tank. By arranging the electromagnetic heating assembly and the net type heating mechanism, air fed into the net type heating mechanism by the air supply mechanism can be rapidly heated to a required temperature through the electromagnetic heating assembly during use, so that hot air can be timely supplied to a drying system for use; and meanwhile, the electromagnetic heating mode is adopted, so that the energy utilization rate can be increased, energy consumption is reduced, and the electricity utilization cost needed by air heating is reduced.

Provided are: a tablet containing 2-{4-[N-(5,6-diphenylpyrazin-2-yl)-N-isopropylamino]butyloxy}-N-(methylsulfonyl)acetamide (compound I); and a method for producing the same. The tablet is an uncoated tablet containing the (A) compound I, (B) starch and a crystalline cellulose, and a (C) binder, or is a coated tablet obtained by providing a coating material on the uncoated tablet. The (C) component is contained in an amount of 1 mass% or more with respect to 100 mass% of the uncoated tablet. The proportion of the crystalline cellulose with respect to 1 part by mass of the starch in the (B) component is 1-5 parts by mass.

This utility model belongs to the field of pharmaceutical machinery technology, specifically relating to a coating device for the sugar coating layer of bisacodyl enteric-coated tablets. It includes a base and a coating pan. A frame is fixedly mounted on the base, and control buttons are located outside the frame. A blower is located inside the frame, and an air duct is fixedly mounted on the frame, communicating with the blower. A tilting and adjustable safety component is provided between the base, frame, and coating pan. This utility model, through corresponding structural improvements, utilizes a worm gear and worm design to enable rapid angle tilting of the coating pan, facilitating feeding by the operator. The design of the arc-shaped through-hole, telescopic rod, and pin allows for positioning at the feeding and rotation positions, reducing the burden on the worm gear and extending the overall service life. Heating by a heating device ensures a uniform sugar coating thickness, preventing the coated tablets from becoming too wet and improving coating efficiency.

The application belongs to the technical field of pharmaceutical preparations, and particularly relates to a diclofenac sodium enteric-coated tablet and a preparation method thereof. The diclofenac sodium enteric-coated tablet comprises a quick-release layer, a slow-release layer and an enteric-coated layer; the quick-release layer comprises the following components in parts by weight: 20-40 parts of diclofenac sodium, 5-15 parts of a disintegrating agent, 20-50 parts of a filling agent, 1-3 parts of a lubricant and 1-5 parts of a binder; the slow-release layer comprises the following components in parts by weight: 50-80 parts of diclofenac sodium, 5-15 parts of crosslinked chitosan, 1-3 parts of a lubricant and 1-5 parts of a binder; and the enteric-coated layer comprises the following components in parts by weight: 20-45 parts of an enteric material and 5-15 parts of N-acetylneuraminic acid derivative. The diclofenac sodium enteric-coated tablet has excellent in-vitro cumulative release degree, and has low hygroscopicity, high stability and high friability.

Provided is a pharmaceutical composition containing compound 1 and having excellent disintegrability and bioavailability.　This pharmaceutical composition contains crystalline cellulose and a granulated substance containing 3-ethyl-4-{4-[4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-1-yl}benzamide or a pharmaceutically acceptable salt thereof, and has a disintegration time of 360 seconds or less in a coated tablet state.

The present invention addresses the problem of providing a tablet which contains acotiamide or a salt thereof at a high concentration and which has not only a good elution property but also good storage stability.　The present invention relates to a tablet characterized by comprising granules that contain (A) acotiamide or a salt thereof, (B) pregelatinized starch, and (C) a disintegrant selected from low-substituted hydroxypropyl cellulose and sodium starch glycolate wherein the content of the component (A) in an uncoated tablet is 65-91 mass%.

The utility model discloses a packaging processing device for enteric-coated tablet production, and relates to the technical field of medicine production. The device comprises a belt type conveying device, a plurality of supporting legs are installed at the bottom of the belt type conveying device, a plurality of supports are installed at the top of the belt type conveying device, a material storage box is installed at the tops of the supports, a discharging pipe is installed at the bottom of the material storage box, and a piece adding cylinder is fixedly connected to the bottom of the discharging pipe. Two tablet plates are arranged at the top of the belt type conveying device, and the positioning part is installed in the belt type conveying device. According to the utility model, the positioning part is arranged, specifically, the motor is started to drive the two-way threaded rod to rotate clockwise, so that the two movable frames and the positioning plates on the outer surface of the two-way threaded rod are close to each other, the motor is closed after the width of the tablet plate is adjusted to a proper position, and the right sides of the two positioning plates are V-shaped, so that the tablet plate can be guided to enter between the two positioning plates to be aligned with the tablet adding cylinder; and the mode can flexibly adapt to tablet plates with different widths, so that the applicability is improved.

The invention provides a sustained-release and quick-release coated tablet and a preparation method thereof, and belongs to the technical field of biological medicines. The outer layer of the core-coated tablet is the quick-release layer, the inner layer of the core-coated tablet utilizes the coating to prolong release, and the core-coated tablet is used as the slow-release layer to realize double-phase release of drugs, so that time-sharing release and outer-layer quick release after single administration are realized, drug peak concentration and effective drug concentration can be reached in a short time after administration, and the inner layer is slowly released by virtue of the coating material; the sustained-release rate is not influenced by the pH value of the intestinal tract, the force of peristalsis and extrusion of gastrointestinal tracts can be borne, the problem that the sudden release rate of the medicine is large in deviation is avoided, and the sustained-release preparation is safer and more effective.

The application belongs to the technical field of pharmaceutical preparations, and particularly relates to a co-processing crystal excipient evaluation method for preventing machine blockage in a tabletting process. The method can accurately predict and easily determine whether the used co-processing excipient will cause tablet core boost rod blockage by comparing and evaluating indexes such as the crystallinity, thermal stability, particle shape and particle size distribution of the co-processing or premixed crystal excipient, thereby directly avoiding the boost rod blockage phenomenon in the production process of the core-coated tablet, reducing the consumption of time, manpower and material resources, providing a simple and fast condition for production, being high in accuracy, being capable of significantly improving the production efficiency of the core-coated tablet, and being very suitable for large-scale industrial production.

The invention relates to the technical field of film coating detection, and discloses surface laser detection equipment after film coating production, the surface laser detection equipment comprises a supporting working base table, the top end of the supporting working base table is fixedly connected with a feeding and discharging mechanism, and the interior of the feeding and discharging mechanism is movably connected with a suspension mechanism; a film coating tablet is placed at the top end of the feeding and discharging mechanism, and a detection mechanism is fixedly connected to one side of the top end of the feeding and discharging mechanism; when film coating tablets are placed above a limiting plate, a voice coil motor is started to enable the limiting plate to vibrate, the film coating tablets are sequentially vibrated into a conical groove of the limiting plate when the limiting plate vibrates, gas is introduced into a suspension mechanism at the moment, and the gas enables the film coating tablets in the conical groove to suspend in the air; the film coating tablet can automatically rotate during suspension, the detection mechanism can comprehensively detect the film coating tablet, contact is not needed during detection, and damage to the film coating tablet is avoided.