55 results about "Coated tablets" patented technology

The present invention provides a tablet and a method for manufacturing a tablet that allows for easy formulation of coated tablets, even when calcium carbonate is used for coating the tablet. [Solution] A tablet coated with a coating layer, wherein the coating layer comprises calcium carbonate granules and a binder for binding the calcium carbonate granules together. The invention also provides a method for manufacturing a tablet coated with a coating layer, comprising a raw material preparation step of dispersing calcium carbonate granules and a binder for binding the calcium carbonate granules together in an aqueous medium to obtain a coating raw material, and a coating layer formation step of coating a tablet with the coating raw material.

The invention discloses a mixed auxiliary material for traditional Chinese medicine film coated tablets and a preparation method of the mixed auxiliary material. The mixed auxiliary material comprises the following components in percentage by weight: 50-60% of etherified crosslinked starch, 15-20% of pregelatinized starch, 10-15% of sodium carboxymethyl starch, 0.6-0.8% of magnesium stearate and 2-3% of talc. The etherified cross-linked starch is used for replacing a traditional polymer, a cross-linked structure of the etherified cross-linked starch blocks water molecule permeation, pre-gelatinized starch improves powder fluidity, crushed talcum powder is mixed with the pre-gelatinized starch, microgaps are filled, a friction system is reduced, and the situation that the sheet surface is rough and prone to sticking is avoided; the dynamic balance of sodium carboxymethyl starch and magnesium stearate ensures the synergism of disintegration and lubrication, and completely avoids the problems of poor tablet hardness, slow disintegration and large weight difference of traditional Chinese medicine film-coated tablets.

A gastro-resistant high-strength unit dosage form includes a solid solution prepared by hot-melt extrusion, whereby the solid solution contains 300 mg posaconazole and an enteric polymer in a specific weight ratio. The unit dosage form may be a capsule or an optionally film-coated tablet.

The invention belongs to the technical field of proton pump inhibition medicine preparations, and relates to a rabeprazole sodium enteric-coated tablet and a preparation method thereof. The technical problems that an existing rabeprazole sodium enteric-coated tablet is insufficient in stability, lagged in dissolution and the like are solved. The enteric-coated tablet consists of a tablet core and an enteric-coated coating layer wrapped outside the tablet core, wherein the tablet core comprises auxiliary materials such as rabeprazole sodium, a filling agent, an adhesive, a stable dissolution promoter and the like; the enteric coating layer comprises an enteric coating material, a plasticizer, an anti-sticking agent and a solvent. Through the synergistic effect of the compound stabilizer and process control, the stability and dissolution performance of the enteric-coated tablet are synergistically improved, meanwhile, the production process is simplified, and the preparation method is suitable for industrial application.

The utility model relates to the technical field of health care product preparation devices, in particular to a health care tablet coating device which comprises an equipment box body, a feeding port is formed in the right end of the equipment box body, and a coating module is arranged in the equipment box body. The coating module comprises a transmission plate, a supporting rod, a supporting ring, a positioning groove, a coating roller, a fixing ring, a positioning sliding block, a spraying pipe and an air inlet pipe, an inserting hole is formed in the center of the transmission plate, a driving module is arranged on the left side of the equipment box body, and the driving module comprises a first positioning ring, a servo motor, a transmission gear, a second positioning ring and a transmission gear ring. One group of coating rollers is fed into the equipment box body, the other group of coating rollers are fed into the equipment box body, then the tablets coated in the previous group of coating rollers are taken out, and the inner walls of the coating rollers are cleaned, so that the cleanliness of the interiors of the coating rollers is effectively kept, the coating quality is improved, and meanwhile, the multiple groups of coating rollers are matched, so that the coating efficiency is improved. The feeding and discharging time is shortened, and the coating efficiency is improved.

The invention provides a bromocriptine mesylate enteric-coated tablet and a preparation method thereof. Specifically, the bromocriptine mesylate enteric-coated tablet comprises a tablet core and an enteric coating layer wrapping the tablet core. The enteric-coated tablet disclosed by the invention is simple in process, good in stability and small in gastrointestinal side effect, the bioavailability of the enteric-coated tablet is more than two times that of a common tablet sold in the market, the dosage is expected to be reduced, the side effect is further reduced, and the enteric-coated tablet has excellent clinical value.

This application discloses a jujube seed and Ganoderma lucidum film-coated tablet and its preparation method. The film-coated tablet uses jujube seed and Ganoderma lucidum in a weight ratio of (2.9–3.1):2 as active raw materials, employs a microcrystalline cellulose and erythritol compound as fillers, and combines them with silica, magnesium stearate, and a specific composite film-coating agent. The preparation method includes raw material pretreatment, water extraction, vacuum concentration, vacuum drying, fluidized bed granulation, total mixing and tableting, and film coating, optimizing each process parameter. This application solves the technical problems of existing traditional Chinese medicine extracts, such as high hygroscopicity, poor compressibility, poor stability, and unclear synergistic effects. The prepared product has high active ingredient content, good stability, rapid disintegration, and good patient compliance, making it suitable for large-scale industrial production and possessing good market application prospects.

This utility model relates to the technical field of coating devices, specifically a coating device for the enteric coating layer of bisacodyl enteric-coated tablets. It includes a cabinet with a roller inside. A rotating ring is connected to the left side wall of the cabinet, and the left end of the rotating ring is rotatably connected to the inner left side wall of the cabinet via a bearing. In operation, bisacodyl tablets are placed into the roller, the door is closed, and a motor drives the drive wheel, transmission belt, driven wheel, rotating ring, and roller to rotate. Support rollers provide support and improve the stability of the roller's rotation. A peristaltic pump draws and delivers the coating solution to the nozzle of a spray gun. The spray gun is connected to a compressed air pipeline, and the compressed air is used to evenly spray the coating solution onto the surface of the bisacodyl tablets for coating. The rotation of the roller causes the tablets to continuously rotate, ensuring the uniformity of the coating solution spray, thereby effectively coating the surface of the bisacodyl tablets with an enteric coating layer.

The invention discloses a galanthamine hydrobromide enteric-coated tablet and a preparation method thereof. The tablet is composed of a tablet core, an isolation layer and an enteric layer, the tablet core contains 5.0%-16.0% of galanthamine hydrobromide, and auxiliary materials such as mannitol, a mixture of magnesium stearate and sodium stearyl fumarate in a specific proportion, colloidal silicon dioxide and the like are matched; the isolating layer adopts an opadry II type film coating, and the enteric-coated layer adopts an opadry Acryl-EZE II type enteric-coated coating. The dissolution rate of the tablet in an acidic medium with the pH value of 1.2 for 2 hours is less than 5%, the release rate of the tablet in a medium with the pH value of 5.5 or 6.8 for 45 minutes is more than or equal to 80%, the tablet is sealed and placed at 40 DEG C + / -2 DEG C / 75% + / -5% RH for 6 months, the stability is good, and the pharmacokinetic parameters are excellent. The preparation method comprises the steps of raw and auxiliary material pretreatment, graded premixing, total mixing and lubricating, tabletting, two-step coating and the like, and the process is stable and controllable. The enteric-coated tablet disclosed by the invention is strong in targeted release property, high in stability and good in bioavailability, and can guarantee the effectiveness and safety of medication.

The invention discloses an in-vitro dissolution method of a posaconazole enteric-coated tablet, which is characterized in that a Tween-80 (TWEEN-80) surfactant is added into a dissolution medium, so that the solubility of the posaconazole enteric-coated tablet in a phosphate buffer solution is remarkably improved, the phenomenon that a solution in a dissolution cup is not uniform is solved, the jump point phenomenon of a dissolution curve is eliminated, and the dissolution rate of the posaconazole enteric-coated tablet is improved. When a phosphate buffer solution added with a certain amount of surfactant is used as a dissolution medium, the accumulated dissolution amount at each time point is stable, the dissolution curve is smooth, the detection result is accurate and reliable, the repeatability and predictability of the dissolution test are remarkably improved, and a more reliable detection method is provided for the initial stage of drug research and development and quality control.

The invention discloses a progesterone enteric-coated tablet processing technology. The technology comprises the following steps: 1, preparing a tablet core; 2, coating an isolating layer; 3, coating an enteric-coated layer; and 4, coloring layer coating. According to the processing technology of the progesterone enteric-coated tablet, the overall technological steps, technological parameters in all the technological steps and the raw material formula are optimized, the steps are simple, operation is easy, the quality of all layers of coatings can be effectively controlled, the stability and consistency of the final product are ensured, the prepared progesterone enteric-coated tablet can stably release medicine in the intestinal tract, and the bioavailability of the product is improved. The absorption speed is high, and the medication comfort and compliance of a patient are improved, so that the requirements of clinical treatment are better met.

This application provides a pharmaceutical composition comprising: an active ingredient, a filler, a disintegrant, and optionally one or more of a binder, a flow aid, and a lubricant. It also provides an enteric-coated tablet comprising (1) a core containing the aforementioned pharmaceutical composition; (2) an optional insulating layer; and (3) an enteric coating layer. The active ingredient in the enteric-coated tablet is not released in the stomach but is released in the intestines, preventing the active ingredient in the composition from degrading in the acidic environment of the stomach.

The utility model provides an air heater for enteric-coated tablet coating production, which comprises an air supply mechanism, a heating mechanism and a temperature adjusting tank, and the air outlet end of the air supply mechanism is connected with the temperature adjusting tank through a first connecting pipe. The heating mechanism is connected with the gas outlet end of the gas supply mechanism through a second connecting pipe, the heating mechanism is connected with the temperature adjusting tank through a third connecting pipe, and a gas distribution mechanism is installed on the temperature adjusting tank. By arranging the electromagnetic heating assembly and the net type heating mechanism, air fed into the net type heating mechanism by the air supply mechanism can be rapidly heated to a required temperature through the electromagnetic heating assembly during use, so that hot air can be timely supplied to a drying system for use; and meanwhile, the electromagnetic heating mode is adopted, so that the energy utilization rate can be increased, energy consumption is reduced, and the electricity utilization cost needed by air heating is reduced.

This utility model belongs to the field of pharmaceutical machinery technology, specifically relating to a coating device for the sugar coating layer of bisacodyl enteric-coated tablets. It includes a base and a coating pan. A frame is fixedly mounted on the base, and control buttons are located outside the frame. A blower is located inside the frame, and an air duct is fixedly mounted on the frame, communicating with the blower. A tilting and adjustable safety component is provided between the base, frame, and coating pan. This utility model, through corresponding structural improvements, utilizes a worm gear and worm design to enable rapid angle tilting of the coating pan, facilitating feeding by the operator. The design of the arc-shaped through-hole, telescopic rod, and pin allows for positioning at the feeding and rotation positions, reducing the burden on the worm gear and extending the overall service life. Heating by a heating device ensures a uniform sugar coating thickness, preventing the coated tablets from becoming too wet and improving coating efficiency.

The application belongs to the technical field of pharmaceutical preparations, and particularly relates to a diclofenac sodium enteric-coated tablet and a preparation method thereof. The diclofenac sodium enteric-coated tablet comprises a quick-release layer, a slow-release layer and an enteric-coated layer; the quick-release layer comprises the following components in parts by weight: 20-40 parts of diclofenac sodium, 5-15 parts of a disintegrating agent, 20-50 parts of a filling agent, 1-3 parts of a lubricant and 1-5 parts of a binder; the slow-release layer comprises the following components in parts by weight: 50-80 parts of diclofenac sodium, 5-15 parts of crosslinked chitosan, 1-3 parts of a lubricant and 1-5 parts of a binder; and the enteric-coated layer comprises the following components in parts by weight: 20-45 parts of an enteric material and 5-15 parts of N-acetylneuraminic acid derivative. The diclofenac sodium enteric-coated tablet has excellent in-vitro cumulative release degree, and has low hygroscopicity, high stability and high friability.

The utility model discloses a packaging processing device for enteric-coated tablet production, and relates to the technical field of medicine production. The device comprises a belt type conveying device, a plurality of supporting legs are installed at the bottom of the belt type conveying device, a plurality of supports are installed at the top of the belt type conveying device, a material storage box is installed at the tops of the supports, a discharging pipe is installed at the bottom of the material storage box, and a piece adding cylinder is fixedly connected to the bottom of the discharging pipe. Two tablet plates are arranged at the top of the belt type conveying device, and the positioning part is installed in the belt type conveying device. According to the utility model, the positioning part is arranged, specifically, the motor is started to drive the two-way threaded rod to rotate clockwise, so that the two movable frames and the positioning plates on the outer surface of the two-way threaded rod are close to each other, the motor is closed after the width of the tablet plate is adjusted to a proper position, and the right sides of the two positioning plates are V-shaped, so that the tablet plate can be guided to enter between the two positioning plates to be aligned with the tablet adding cylinder; and the mode can flexibly adapt to tablet plates with different widths, so that the applicability is improved.

The invention provides a sustained-release and quick-release coated tablet and a preparation method thereof, and belongs to the technical field of biological medicines. The outer layer of the core-coated tablet is the quick-release layer, the inner layer of the core-coated tablet utilizes the coating to prolong release, and the core-coated tablet is used as the slow-release layer to realize double-phase release of drugs, so that time-sharing release and outer-layer quick release after single administration are realized, drug peak concentration and effective drug concentration can be reached in a short time after administration, and the inner layer is slowly released by virtue of the coating material; the sustained-release rate is not influenced by the pH value of the intestinal tract, the force of peristalsis and extrusion of gastrointestinal tracts can be borne, the problem that the sudden release rate of the medicine is large in deviation is avoided, and the sustained-release preparation is safer and more effective.

The application belongs to the technical field of pharmaceutical preparations, and particularly relates to a co-processing crystal excipient evaluation method for preventing machine blockage in a tabletting process. The method can accurately predict and easily determine whether the used co-processing excipient will cause tablet core boost rod blockage by comparing and evaluating indexes such as the crystallinity, thermal stability, particle shape and particle size distribution of the co-processing or premixed crystal excipient, thereby directly avoiding the boost rod blockage phenomenon in the production process of the core-coated tablet, reducing the consumption of time, manpower and material resources, providing a simple and fast condition for production, being high in accuracy, being capable of significantly improving the production efficiency of the core-coated tablet, and being very suitable for large-scale industrial production.

The invention discloses an estradiol valerate film-coated tablet and a preparation method thereof. The estradiol valerate film-coated tablet comprises the following components in parts by weight: 1 part of estradiol valerate, 60-80 parts of a filler, 10-25 parts of a disintegrating agent, 5-12 parts of an adhesive, 1-3 parts of a flow aid, 1-3 parts of a lubricant and 8-14 parts of a film coating premix, and the filling agent is anhydrous lactose. After a sugar coating is changed into a film coating, the front end of the preparation is obviously and quickly dissolved out and is not similar to the original sugar-coated tablet, the tablet core is disintegrated in a corrosion manner by adjusting the dosage of lactose in the prescription, and the whole dissolution of the tablet is similar to the dissolution of the original sugar-coated tablet by adjusting the weight increment of the film coating. The process is simple, industrial production is facilitated, and the stability of the preparation is obviously improved.

To provide a linagliptin-containing pharmaceutical composition, particularly a linagliptin-containing film-coated tablet, and a method for producing the same, which can suppress the delayed disintegration, delayed dissolution, and increase of related substances that occur over time by simpler means. [Solution] The invention provides linagliptin as an active ingredient, along with excipients, disintegrants, binders, and lubricants. The binder used is a polyvinyl alcohol / acrylic acid / methyl methacrylate copolymer or a polyvinyl alcohol / polyethylene glycol / graft copolymer. The uncoated tablets are prepared by a wet granulation method called fluid bed granulation drying. Hypromellose is used as the film coating agent, and the film coating layer does not contain polyethylene glycol, resulting in linagliptin-containing film-coated tablets.

1.The name of the design product: packaging box (alengling aspirin enteric-coated tablets). 2.The use of the design product: used for the outer packaging of medicines. 3.The design points of the design product: the combination of shape, pattern and color. 4.The picture or photo that best shows the design points: front view. 5.The design contains colors.

The application belongs to the technical field of direct compression of pharmaceutical preparations, and particularly relates to a sustained-release isosorbide mononitrate tablet and a preparation method thereof. The sustained-release tablet is composed of a sustained-release tablet core and a coating layer. After isosorbide mononitrate, hydroxypropyl cellulose, palm wax, silicon dioxide, microcrystalline cellulose-lactose and talc powder are mixed, the powder is directly compressed into a tablet. The obtained tablet is coated into a film-coated tablet by using a moisture-proof coating material (AMB). The powder direct compression technology is adopted, so that the technical complexity is greatly reduced, and the wet heat unit operation is avoided. The preparation process is simple, and the quality is stable.

The invention belongs to the technical field of medicines, and particularly relates to a tiopronin composition and a preparation method thereof. The composition is an enteric-coated tablet which is composed of a tablet core and an enteric coating layer, wherein the tablet core contains tiopronin, porous starch, chitosan, vitamin C and other pharmaceutically acceptable filler, adhesive, disintegrating agent and lubricant. The tablet prescription can reduce the impurity content of the preparation product and improve the stability; meanwhile, the dissolution rate of tiopronin is improved; the content is uniform, unpleasant odor is effectively covered, and improvement of patient compliance is facilitated; the preparation method of the composition is simple and suitable for industrial production.

The present invention relates to a coated tablet composition comprising omeprazole (KN510) with improved stability and a method for preparing the same. More specifically, the present invention relates to a bilayer coated tablet composition comprising omeprazole, an enantiomer thereof, or a pharmaceutically acceptable salt thereof, and a method for preparing the same. In the present invention, in order to increase the stability of a KN510 tablet (30 mg) comprising omeprazole, a tablet composition is designed using calcium carbonate. It is proved that when mannitol and lactose are contained as excipients, tablets satisfying disintegration, dissolution and friability standards can be prepared, and the increase of related substances is significantly reduced.

The present invention relates to a coated tablet composition comprising trimetazidine (KN713) and a process for the preparation thereof. In the invention, in order to improve the flowability of an active ingredient trimetazidine of a KN713 tablet (30mg), silicified microcrystalline cellulose, mannitol and colloidal silicon dioxide are used to design a tablet composition, and magnesium stearate is added to solve a film forming phenomenon occurring in a tabletting process. Furthermore, when a KN713 tablet (30 mg) is produced using the coated tablet composition of the present invention, it is confirmed that a tablet conforming to disintegration, dissolution, and friability standards can be produced, and the increase in related substances is significantly reduced. Therefore, the tablet composition of the present invention can be effectively used as an anticancer tablet.

The invention discloses a compound vitamin coated tablet which is prepared from compound vitamins, mineral substances, a diluent, an adhesive, a disintegrating agent, a lubricant and a gastric-soluble film coating premix. According to the present invention, the core-coated tablet preparation technology is adopted to prepare the tablet into the two-layer or three-layer core-coated tablet, such that the disintegration of the product is accelerated, and the risk of vitamin degradation during the storage period is effectively reduced;

The invention relates to a herbal preparation in the form of film-coated tablets for the supportive treatment of allergic rhinitis and sinusitis, and a process for preparing such a preparation. The preparation according to the invention contains herbal extracts obtained from a mixture of medicinal herbs including Bupleurum root (Radix Bupleurum), Platycodon grandiflorus root (Radix Platycodi grandiflori), Xanthium strumarium fruit (Fructus Xanthii strumarii), Magnolia officinalis flower (Flos Magnoliae), and Oroxylum indicum bark (Cortex Oroxyli indici), in which each herb is used in appropriate amounts to create synergistic anti-inflammatory, anti-allergic, decongestant, expectorant, and immune-enhancing effects on the respiratory mucosa. The preparation also includes a film-coating system containing a film-forming polymer, plasticizer, and coloring agent, along with tablet-forming excipients such as preservatives, fillers, stabilizers, and anti-caking agents in appropriate proportions to create a highly stable film-coated tablet.The preparation according to the invention has the advantages of preserving the active ingredients of the medicinal herbs, increasing stability, improving bioavailability, being convenient to use, and contributing to enhancing the effectiveness of supporting the treatment of symptoms of allergic rhinitis and sinusitis. It is also safe for long-term use because the preparation contains herbal extracts of natural origin that have been used for a long time in traditional medicine, and does not contain synthetic vasoconstrictors, corticosteroids, or antibiotics. In addition, the extraction and purification process helps remove impurities and reduce irritating components, thereby limiting the risk of unwanted side effects with prolonged use.

The invention relates to the technical field of tablet presses, in particular to a tablet press and a preparation method of a chip wrapping piece. The tablet press comprises a rotary table mechanism, a feeding mechanism, a core falling mechanism and a pressing mechanism. The rotary table mechanism comprises a first encoder, a material disc and a first driving motor used for driving the material disc to rotate in the circumferential direction, the core falling mechanism comprises a chip conveying part, a core disc, a second encoder and a second driving motor used for driving the core disc to rotate in the circumferential direction, and the first encoder is linked with the second encoder; the die cavity of the material disc is aligned with the chip accommodating hole of the core disc at a set position, so that the chip falls in the center of the die cavity. The first encoder and the second encoder work in a linkage mode, the relative movement of the material disc and the core disc is synchronously adjusted according to the real-time position data of the first encoder and the second encoder, and therefore high-precision alignment of the die cavity of the material disc and the chip containing hole of the core disc at the set position is achieved, and the problem that a chip is prone to deviating from the center is fundamentally solved.

The utility model relates to an enteric-coated tablet counting and subpackaging device which aims at solving the technical problem that at present, counted medicine cannot be conveniently and rapidly collected in a centralized mode, the enteric-coated tablet counting and subpackaging device comprises a fixing plate, a material distributing shell and a material conveying device, a plurality of counting holes are evenly formed in the surface of the fixing plate, and the material distributing shell is attached to the top of the fixing plate; the blocking plate is arranged at the bottom of the fixing plate and is arranged under the material distributing shell; the strip-shaped hole is formed in one side wall of the fixing plate, a driving assembly is installed in the strip-shaped hole, and the driving assembly is used for driving the material distributing shell and the blocking plate to move; according to the tablet counting device, the driving assembly drives the distributing shell to move, so that tablets can be guided into the counting holes to be counted, the counted tablets can automatically fall into the collecting hopper, the tablets can be rapidly collected, the working efficiency is improved, the labor intensity of workers is reduced, and the working efficiency is improved. And the phenomenon that the tablets are scattered is avoided.

The present invention relates to over the counter (OTC) film coated tablet compositions comprising one or more types of vitamins. Specifically, the invention focuses on formulations that include B vitamins, such as thiamine (B1), riboflavin (B2), nicotinamide (B3), pantothenic 5 acid (B5), pyridoxine (B6), biotin (B7), folic acid (B9), and cobalamin (B12). These vitamin- enriched tablets are intended for dietary supplementation to support various bodily functions, including energy metabolism, nervous system health, and the maintenance of healthy skin, hair, and eyes.