15 results about "Enteric coated" patented technology

The invention discloses a mesoporous polydopamine (MPDA) nanoparticle which is loaded with a CeO2 nano enzyme and mitoxantrone mesylate (MitoQ) and is released by an intestinal tract, a preparation method of the mesoporous polydopamine (MPDA) nanoparticle, and an application of the mesoporous polydopamine (MPDA) nanoparticle, the preparation method of the mesoporous polydopamine (MPDA) nanoparticle, the preparation method of the mesoporous polydopamine (MPDA) nanoparticle and the preparation method of the mesoporous polydopamine (MPDA) nanoparticle, the preparation method of the mesoporous polydopamine (MPDA) nanoparticle, and the preparation method of the mesoporous polydopamine (MPDA) nanoparticle. The mesoporous polydopamine nanoparticle loaded with the CeO2 nano enzyme and the mitoxantrone mesylate and released by the intestinal tract comprises mesoporous polydopamine loaded with the CeO2 nano enzyme and MitoQ, and an enteric coating of chitosan and sodium alginate. The preparation method comprises the following steps: synthesizing mesoporous polydopamine by adopting a triblock copolymer as a template, then loading a small molecular drug MitoQ into MPDA through ultrasonic waves, and loading CeO2 nano-enzyme on the surface of MPDA through metal coordination to form MPDA (at) CeO2-MitoQ. And finally, coating chitosan and sodium alginate on the surfaces of the nanoparticles through electrostatic adsorption to obtain the final MPDA (at) CeO2-MitoQ (at) SA / CS. The drug-loaded nano-particles prepared by the preparation method disclosed by the invention have a good treatment effect on ulcerative colitis.

The invention discloses an oral vaccine as well as a preparation method and application thereof, and relates to the technical field of pharmaceutical preparations. The oral vaccine comprises a core, and a permeation enhancing layer, an active molecular layer and an enteric coating layer which are sequentially coated on the surface of the core, the core is a biodegradable polymer nano particle; the permeation enhancing layer is a polydopamine layer loaded with a permeation enhancer; the active molecular layer is a chitosan layer loaded with an antigen and a targeting substance. The oral vaccine provided by the embodiment of the invention is good in stability, can ensure that the antigen is stable in gastrointestinal tracts and keeps activity, realizes targeted release of intestinal tracts, can activate far-end mucous membrane tissues at the same time, realizes broad-spectrum IgA and IgG immunization, and is suitable for delivery of various oral antigens.

The present invention relates to a sustained-release enteric coating pellet and a method for manufacturing same and, more specifically, to a sustained-release enteric coating pellet and a method for manufacturing same, the sustained-release enteric coating pallet comprising: an inert core; a coating layer of an active ingredient formed on the core; a sustained-release coating layer formed on the coating layer of the active ingredient; and an enteric coating layer formed on the sustained-release coating layer, wherein: the active ingredient is tamsulosin or a pharmaceutically acceptable salt thereof; the sustained-release coating layer comprises a sustained-release agent and a coating stabilizer; the coating stabilizer is polyvinyl alcohol, such that the pellet allows for the sustained release in a continuous and stable manner under enteric conditions and exhibits high reproducibility even when manufactured under various environmental or process conditions.

The application discloses a bactericidal and anti-inflammatory multi-layer microneedle patch with programmed response and a preparation method, and relates to the technical field of biomedical materials and wound repair. The microneedle patch comprises an outer shell layer, a core layer and a sandwich layer, the sandwich layer wraps the core layer, and the outer shell layer is coated outside the needle body of the sandwich layer. The component of the core layer is PVP and PVA loaded curcumin nanoparticles. The component of the outer shell layer is PVP and PVA loaded copper chloride. The sandwich layer is an enteric coating. The preparation method adopts reverse combination from solid to liquid, the solidified inner core is used as a male die, and is directly added to an un-solidified solution in a female die to form a mechanical interlocking structure. The application realizes layered time-sequencing drug delivery under multi-signal response, has good antibacterial, anti-inflammatory and wound healing abilities, and good mechanical properties, biocompatibility and large-scale preparation potential, and can significantly improve the antibacterial and repair efficiency of chronic wounds.

The invention provides an enteric-coated tablet for treating neuritis and a preparation method of the enteric-coated tablet. The enteric-coated tablet is prepared from the following components in percentage by weight: 0.01%-1% of mecobalamin, 60%-80% of butanedisulfonic acid adenosyl methionine, 10%-30% of a diluent, 4%-9% of an adhesive, 1%-5% of a disintegrating agent, 0.1%-1% of a lubricant and 8%-16% of an enteric-coated material. The enteric-coated tablet disclosed by the invention is simple in production process, universal in production equipment and low in cost, mainly overcomes the defect of large in-vivo absorption difference, and has a remarkable curative effect on treating neuritis.

The present application relates to the technical field of pet feed additives, and discloses a pet coated postbiotic feed additive containing enzymes and a preparation method, the additive comprising core particles formed by mixing postbiotics and complex enzymes coated with a slow-release coating, and an enteric layer coated on the outside of the core particles. The preparation method comprises: preparing the postbiotics and the slow-release coated complex enzymes respectively, mixing the two to form core particles, and then enteric coating the core particles. The present application protects the activity of functional components through a double-coating structure, so that the functional components are released in the intestinal tract and synergize. The additive can effectively improve the digestion of pet protein, regulate the intestinal microenvironment, significantly proliferate beneficial bacteria such as lactobacillus and prasrmanella, and inhibit escherichia coli, thereby reducing soft stool and maintaining the intestinal health of pets.

An omeprazole delayed release tablet comprises a core and an enteric coating over the core. The core consists essentially of omeprazole, lactose, sodium starch glycolate, sodium stearate, and sodium stearyl fumarate. The enteric coating over the core consists essentially of hydroxypropyl methyl cellulose (HPMC) acetate succinate, triethyl citrate, sodium lauryl sulfate, talc, monoethanol amine, and less than 500 ppm of residual ammonium hydroxide.

Embodiments herein provide a pharmaceutical formulation comprising an anti-inflammatory antipyretic agent with reduced side effects, addressing gastric problems. An enteric-coated tablet of the present invention comprises esomeprazole, aceclofenac, and paracetamol, along with maize starch, microcrystalline cellulose, povidone K30, colloidal anhydrous silica, and magnesium stearate.

The application belongs to the technical field of coating materials, and particularly relates to a biodegradable medicinal casing based on a natural polysaccharide compound and a preparation method thereof. The biodegradable medicinal casing based on the natural polysaccharide compound comprises the following components in parts by weight: the enteric coating comprises the following components in parts by weight: 1-5 parts of pullulan, 20-25 parts of an enteric material, 6-10 parts of seaweed extract, 0.2-0.5 parts of a plasticizer, 5-9 parts of an anti-sticking agent, 0.20-0.25 parts of a pH regulator and 40-45 parts of water. The medicinal casing prepared in the application has high dissolution rate, strong stability and fast release speed when omeprazole is coated.

The invention discloses a sterilization and anti-inflammation multilayer microneedle patch with programmed response and a preparation method, and relates to the technical field of biomedical materials and wound repair. The microneedle patch comprises a shell layer, a core layer and a sandwich layer, the sandwich layer wraps the core layer, and the shell layer wraps a needle body of the sandwich layer; the components of the core layer are PVP (Polyvinyl Pyrrolidone) and PVA (Polyvinyl Alcohol) loaded curcumin nanoparticles; the components of the shell layer are PVP (Polyvinyl Pyrrolidone) and PVA-loaded copper chloride; the sandwich layer is an enteric coating; according to the preparation method, solid-to-liquid reverse combination is adopted, a cured inner core serves as a male mold and is directly added into an uncured solution in a female mold, and a mechanical interlocking structure is formed; layered sequential drug delivery under multi-signal response is achieved, the hydrogel has good antibacterial, anti-inflammatory and wound healing promoting capacity, good mechanical performance, biocompatibility and large-scale preparation potential, and the antibacterial and repairing efficiency of chronic wounds can be remarkably improved.

The application discloses a kind of active oxygen response drug release lipid nanoparticles and its preparation method and application, belong to the technical field of pharmaceutical preparation, the lipid nanoparticles include functional drug, lipid material and enteric coating material;The functional drug is anti-inflammatory drug or intestinal barrier regulator, the anti-inflammatory drug includes dexamethasone acetate, 5-amino salicylate or sulfasalazine, and the intestinal barrier regulator is PI3K inhibitor;The lipid material is the alpha-tocopherol and monoglyceride of thiole ketone bond bonding, obtained by the reaction of alpha-tocopherol, double carboxyl crosslinking monomer containing thiole ketone bond and monoglyceride;The lipid nanoparticles have active oxygen response drug release and colon sustained-release performance, can promote intestinal barrier repair, reduce inflammatory response and the like.

The invention discloses an enteric-coated vegetable gelatin soft capsule and a preparation method thereof, and belongs to the technical field of soft capsule preparation, and the enteric-coated vegetable gelatin soft capsule comprises the following components in parts by weight: 50-80 parts of vegetable-based gelatin powder, 0.5-5 parts of cellulose ether ester, 10-50 parts of a plasticizer, 1-10 parts of a water-retaining agent and 10-20 parts of water; the enteric-coated plant soft capsule does not contain an enteric coating, so that a coating process does not need to be added, the slow infiltration risk caused by influence on soft capsule seams in the coating process is reduced, and the enteric-coated effect is improved; by optimizing the preparation process, the preparation process is simplified, the manufacturing cost is reduced, and the prepared soft capsule meets the requirement of disintegration time limit and is good in performance; the soft capsule is free of protein residues, allergy is effectively reduced, and the requirements of vegetarians can be met; the vegetable gum is used as a natural component, meets the market preference of'natural and additive-free ', has small stimulation to human bodies, and reduces the harm of auxiliary materials to the human bodies.

The invention belongs to the technical field of medicine preparation processes, and provides a penicillin V potassium tablet and a preparation method thereof. The preparation method comprises the following steps: (1) putting a plain tablet of a penicillin V potassium tablet into a coating pan, preheating, spraying an enteric coating solution onto the rotating plain tablet, drying, and cooling to room temperature to obtain an enteric coated tablet; acrylic resin II and Eudragit RS100 are adopted as a coating agent of the enteric coating solution; (2) putting the enteric coated tablet into a coating pan, preheating, spraying the gastric-soluble coating liquid onto the rotating enteric coated tablet, drying, and cooling to room temperature to obtain a double-layer coated tablet; and a coating agent of the gastric-soluble coating solution adopts acrylic resin IV. The penicillin V potassium tablet prepared by the preparation method disclosed by the invention has a double-layer film coating layer and an extremely good taste masking effect, and can be slowly and stably released in intestinal tracts, and meanwhile, a coating agent adopted by the double-layer film coating layer is close to and single in component.

A crocetin preparation with high bioavailability, and the use thereof. Crocetin disodium is used as a main active ingredient, and prepared into an oral enteric coated preparation with high bioavailability and rapid absorption. By means of optimizing the formulation and process of the oral preparation, a lipid material, a solubilizer, and a pH modulator are used as key ingredients in the enteric coated crocetin disodium preparation, which synergistically solves critical technical problems in terms of druggability, such as the aqueous insolubility and poor solution stability of crocetin, and significantly enhances the stability, solubility, and absorption efficiency of the pharmaceutical ingredients in vivo, thereby elevating the oral bioavailability of an insoluble crocetin preparation, and improving the pharmacokinetic parameters and efficacy of the drug. The oral enteric coated preparation can effectively prevent or treat cardiovascular and cerebrovascular diseases and metabolic diseases, greatly expands the clinical value and druggability of crocetin, and has a simple preparation process and low cost.

The application discloses a preparation method of aspirin enteric-coated tablets based on specific particle size screening and belongs to the technical field of pharmaceutical preparations. In aspirin raw materials used in the enteric-coated tablets, the mass percentage of particles with a particle size between a three-number sieve aperture of 355 mu m plus or minus 13 mu m and a seven-number sieve aperture of 125 mu m plus or minus 5.8 mu m accounts for more than 90% of the total particles; the enteric-coated tablets comprise aspirin, a filling agent, a disintegrating agent and an enteric-coated layer. The application precisely controls the proportion of aspirin raw material particles with a particle size between a three-number sieve and a seven-number sieve to be more than 90%, and optimizes the selection of auxiliary materials and the process parameters of the preparation, such as the parameters of direct mixing, direct compression of powder and enteric-coated coating and the like, based on the raw material with a specific particle size range, so that the synergistic effect of each link is ensured, and the product quality is improved. The preparation method of the aspirin enteric-coated tablets based on specific particle size screening has the advantages of stable preparation process, high dissolution rate, good quality stability and the like, and improves the overall quality and curative effect of the medicine.