621 results about "Small intestine" patented technology

The invention belongs to the technical field of biology, and discloses a reagent combination or kit for constructing intestinal organs and application of the reagent combination or kit. According to the reagent combination or the kit, intestinal organs can be obtained from cell-derived epithelial cells obtained from a donor in a non-invasive manner, and the obtained intestinal organs can be cryopreserved and recovered and can be amplified in vitro for a long time; transcriptome characteristics are similar to those of real human small intestine tissues, and typical marker genes of various small intestine pedigree cell types are highly expressed; compared with intestinal organs obtained through induction of pluripotent stem cells, the intestinal organs have more intestinal pedigree characteristics, and the intestinal function development is more mature; after being promoted to be mature, the intestinal organ also highly expresses genes related to drug absorption and metabolism, has drug absorption capability similar to that of an immortalized intestinal cell line, but more prominently shows intestinal cell lineage characteristics, is closer to an intestinal environment in a real human body, and can be used for screening intestinal disease drugs; the intestinal barrier function is realized.

The invention discloses a personalized in-vitro total digestion glycolysis simulation system, and belongs to the technical field of in-vitro digestion simulation. According to the invention, by dynamically regulating and controlling the emptying amount and the flow velocity of digestive juice, the process of'digesting and absorbing at the same time 'in the small intestine is simulated, and the interaction of colon flora and colon organs is enhanced in combination with a micro-fluidic chip technology, so that the accurate detection of the digestion process and digestion products is realized. The digestion product simulated by the method disclosed by the invention and the flora structure are very close to the real in-vivo structure, so that the method has relatively high authenticity and credibility.

The invention discloses a method for simulating small intestine-colon dynamic digestion and glycolysis of polysaccharide-based food, and belongs to the technical field of food detection. The small intestine-colon simulated digestion and absorption system special for the polysaccharide-based food comprises a small intestine digestion simulation system, a sampling and emptying system, a large intestine glycolysis simulation system and a central intelligent control and display system (a pH control system, a temperature control system, a stirring rate control system, a gas path system and a flow rate control system). Aiming at the limitations that an existing human gastrointestinal tract digestion in-vitro simulation system cannot be continuous, is short in period and the like, the in-vivo real digestion and glycolysis physiological environment and process are simulated, intestinal peristalsis waves and digestion and glycolysis of polysaccharide-based food are simulated, automatic sampling can be achieved, generation of glucose in small intestines can be detected on line, and the in-vitro simulation system fits the real human physiological environment.

The invention relates to the field of biological agents, in particular to a compound probiotic preparation rich in organic selenium and a preparation method of the compound probiotic preparation, and efficient synergistic delivery is achieved through plant micromolecule organic selenium extraction and a multi-layer microemulsion embedding technology. The preparation consists of a core active component, a carrier system and a curcumin compound. The plant micromolecular organic selenium is extracted from cardamine hupingshanesis and high-selenium corn flour through an HLUP technology, and the bioavailability is remarkably improved. A corn protein modified W / O / W microemulsion is adopted as a carrier, an outer layer membrane is stable in an acid environment, and an inner layer accurately releases selenium to small intestines; a protective agent composed of trehalose and glucose inhibits ice crystal damage, and glutaraldehyde crosslinking enhances the mechanical strength of the membrane. Curcumin and selenium synergistically enhance antioxidant and immunomodulatory functions, and promote phagocytic activity of macrophages. The stability and bioavailability bottlenecks of a traditional preparation are broken through, and an innovative scheme is provided for functional food development.

The invention discloses a feed additive, feed, a feeding method and a selenium-enriched cow milk obtaining method. The feed additive comprises a core material and a coating film, the core material comprises a carrier and organic selenium, and the coating at least comprises a material which is stable in a rumen environment and has a swelling effect in a small intestine; the selenium content in the feed additive is 0.6 to 1.5 g / kg. According to the invention, cow milk with higher selenium content can be obtained under the condition that a smaller amount of organic selenium is added, the selenium content in the cow milk can be increased to 9ug / 100g or above, and the absorption and utilization rate of the organic selenium is remarkably increased.

The invention relates to the technical field of biological medicine, in particular to a lactobacillus-sourced extracellular vesicle and application of the lactobacillus-sourced extracellular vesicle in prevention and treatment of necrotizing enterocolitis, the extracellular vesicle is prepared from lactobacillus, the lactobacillus is Lactobacillus rhamnosus GG, the strain is purchased in the American Center for Type Culture Collection, and the preservation number is ATCC 53103. The preparation method of the extracellular vesicles comprises the following steps: carrying out ultracentrifugation on a lactobacillus culture solution, removing thalli, then collecting supernate, carrying out primary microfiltration, taking micro-filtrate, carrying out differential centrifugation, resuspending precipitates by using PBS, then carrying out secondary microfiltration, collecting the micro-filtrate, carrying out density gradient centrifugation, and collecting a 30-45% interface vesicle layer. The invention discloses a synergistic effect mode between intestinal symbiotic flora and intestinal epithelial cell metabolic molecules for the first time, and the discovery is expected to construct a brand-new mechanism normal form for regulating the host intestinal barrier function by flora.

The invention provides a preparation method of a calcium emulsifying and embedding system with high bioaccessibility, which comprises the following steps: S1) heating and mixing biomacromolecules and an emulsifier in water to obtain a water phase; the biomacromolecules are protein colloids and / or polysaccharide colloids; the method comprises the following steps: heating and mixing a calcium source substance and anhydrous cream to obtain an oil-solid phase; and S2) mixing the oil-solid phase with a water phase, and emulsifying to obtain the calcium emulsifying and embedding system. Compared with the prior art, the preparation method has the advantages that the natural macromolecular protein and / or polysaccharide with high nutritional value is used as a carrier, the calcium source substance is embedded through a water-oil-solid three-phase emulsification technology, and the preparation method is simple, easy to operate, low in cost and environmentally friendly; in addition, a water-oil-solid three-phase homogenized emulsion is created, the problem that the dispersion stability of milk mineral salt in a liquid food matrix is poor is effectively solved, release of free calcium ions in the small intestine environment can be promoted, and the calcium bioaccessibility is remarkably improved.

The invention belongs to the technical field of feed additives, and particularly relates to slow-release fat powder for pigs and a preparation method of the slow-release fat powder. The slow-release fat powder for pigs comprises an intragastric adhesion-slow release layer, a small intestine forepart bile acid response controlled release layer and a small intestine posterior microbe response controlled release layer. The prepared slow-release fat powder for the pigs is good in stability, accurate release of different nutritional ingredients in different parts of gastrointestinal tracts of the pigs can be achieved, and powerful support is provided for sustainable development of the pig raising industry.

Methods of enhancing visualization of a body lumen. A device including a capsule endoscope and a plurality of struts attached thereto may be positioned into the body lumen. The plurality of struts of the device may self-expand within the body lumen from a constrained configuration to an expanded configuration in which the plurality of struts extend both radially and axially away from a camera lens of the capsule endoscope so as to form a frame around the camera lens in the expanded configuration. The camera lens may image through the frame into the body lumen. At least a portion of the frame or a material constraining the struts of the frame may dissolve to allow passage of the device from the body lumen.

The invention relates to the field of microorganisms, and discloses a Lactococcus lactis subsp. Lactis VB346 which is preserved in the China Center for Type Culture Collection on September 20, 2024, and the preservation number is CCTCC NO: M 20242013. The invention further discloses a preparation method of the Lactococcus lactis subsp. Lactis VB346. The lactococcus lactis subsp. Lactis VB346 disclosed by the invention has the capability of efficiently degrading purine nucleoside, and can decompose purine nucleoside in ingested food in intestinal tracts, so that the absorption amount of purine nucleoside by small intestines is reduced. The polypeptide has the ability of degrading bilirubin, and can be used for treating or improving hyperbilirubinemia, or improving liver and gall injury caused by hyperbilirubin; meanwhile, the acid resistance required by survival in the stomach, the cholate tolerance required by survival in the intestinal tract and the stable survival ability in the intestinal tract are achieved, and the bacillus subtilis has huge application prospects in preparation of drugs, microbial agents, health care products or food.

The invention discloses double-layer cross-linked artificial matrigel and an application method of the double-layer cross-linked artificial matrigel in a small intestine micro-physiological system. Low-concentration calcium ions are adopted for primary crosslinking to form a soft inner layer structure, and then high-concentration calcium ions are used for secondary crosslinking to improve the overall rigidity. The matrigel is used for dynamic culture of small intestine organoid and is combined with a micro-fluidic chip to form a small intestine micro-physiological system. In the system, the digestive absorption process of the small intestine is dynamically simulated by controlling the flow ratio and rate of digestive fluid and culture fluid. Compared with the traditional natural matrigel, the matrigel disclosed by the invention has more appropriate mechanical strength and structural stability, supports long-term growth of the organoids, and improves the multiplication capacity, tight connection and structural integrity of the organoids in an in-vitro environment. The method can be used for researching intestinal diseases, food digestion and drug absorption, and is an in-vitro digestion simulation platform with high biocompatibility and stability.

The invention belongs to the field of food processing, and discloses a preparation method and application of a targeted colon delivery polyunsaturated fatty acid grease microcapsule. 11S globulin in soybeans and Arabic gum are used as wall materials of the microcapsule, complex coacervation of the 11S globulin in the soybeans and the Arabic gum is induced under a certain pH condition, so that oil drops are wetted by a coacervate, a core-shell structure is formed, a coacervate phase is further stabilized through glucan to inhibit coalescence, and on the basis, the microcapsule is prepared. And tannic acid, polysaccharide and protein can form hydrogen bonds and generate hydrophobic interaction to further crosslink the condensed phase to obtain the microcapsule capable of resisting digestion of the stomach and the small intestine, so that colon delivery of polyunsaturated fatty acid is realized.

The invention discloses a capsule medicament for endoscopic treatment of ulcerative colitis and a preparation method thereof, and belongs to the technical field of biological medicine, the capsule medicament is composed of a capsule matrix and a drug matrix; by adopting a dual control mechanism of an enteric layer coating and a pH response layer coating, accurate release of a medicine at a colon diseased region is ensured, medicine waste of the stomach and the small intestine is reduced, the medicine concentration at a focus is improved, mesalazine or budesonide is combined with the composite composition for treatment, inflammatory response is rapidly inhibited, acute symptoms are controlled, and the curative effect is good. A multi-mechanism synergistic treatment mode is adopted, the anti-inflammatory and repairing effects are enhanced, the clinical remission rate and the mucous membrane healing rate are remarkably improved, the pH response layer is dissolved in a colon alkaline environment, and the MMP-9 peptide cross-linking agent is subjected to enzymolysis at an inflammation part, so that the medicine is continuously released at a focus, the administration frequency is reduced, the compliance of a patient is improved, and the curative effect is good. In addition, the spherical gel particles in the medicament can prevent the medicament from being disintegrated too early in the intestinal tract, and the long-acting effect can be maintained.

The pneumatic soft robot comprises a front air bag, a corrugated pipe and a rear air bag which are sequentially and coaxially connected, the front air bag, the corrugated pipe and the rear air bag are all provided with independent ventilation air paths, and the front air bag and the rear air bag can achieve radial volume expansion by means of inflation. Therefore, anchoring in the small intestine is achieved, and the corrugated pipe can stretch out and draw back in the axial direction by means of air inflation. Different from a previous intestinal tract detection pneumatic robot, the core idea of the invention is that the small intestine is dragged by using the pneumatic robot, the robot does not need to crawl in the small intestine, a traditional enteroscope outer sleeve operation mode can be replaced, and medical personnel can conveniently carry out related detection.

The invention relates to the technical field of feed additives, and discloses a ruminant animal fattening and growth-promoting feed additive which comprises the following components in percentage by mass: 22-28 parts of phytosterol, 42-48 parts of a rumen protection type amino acid compound, 11-14 parts of a compound probiotic preparation, 6-7.5 parts of a compound enzyme preparation, 9-11 parts of a trace element compound and 4-4.8 parts of a buffer system. According to the preparation method of the fattening and growth-promoting feed additive for ruminant animals, a modified hydrogenated palm oil and lecithin compound is used as a rumen protection type amino acid coating material, and a high-pressure homogenizer is used for performing multi-stage homogenizing treatment, so that a coating layer is more compact in structure, and the weight of the coating layer is increased; the rumen microorganism lipase decomposition resistance is enhanced through the synergistic effect of the composite material, particle distribution is optimized in combination with a refined homogenizing process, the release controllability and absorption efficiency of amino acid in small intestines are improved, and the problems that a traditional single coating material is easy to decompose and the particle size is extensively controlled are solved.

The invention relates to a lactobacillus rhamnosus YYSJ019 strain for relieving obesity and application of the lactobacillus rhamnosus YYSJ019 strain. The lactobacillus rhamnosus YYSJ019 strain is classified and named as lactobacillus rhamnosus, and the preservation number of the lactobacillus rhamnosus YYSJ019 strain is CGMCC (China General Microbiological Culture Collection Center) No.33472. The strain has good tolerance and high surface hydrophobicity in gastric juice, and has the potential of smoothly entering the gastrointestinal tract of a human body; the bacterial strain has excellent intestinal adhesion capability, and provides a basis for continuously playing a probiotic effect; the strain can slow down weight gain of obese mice and improve fat accumulation, liver injury and inflammation in bodies of the obese mice; the blood sugar metabolism capability and the blood fat metabolism capability can also be improved, and the potential of preventing and treating hyperglycemia or hyperlipidemia is achieved; in addition, a mouse small intestine endocrine cell line (STC-1 cell line) can be stimulated to generate the glucagon-like peptide-1, and the glucagon-like peptide-1 has the potential of improving diseases caused by insufficient secretion of the glucagon-like peptide-1; the effects of reducing uric acid in vitro and reducing uric acid in vivo are achieved, and the potential of preventing and treating hyperuricemia is achieved.

The invention belongs to the technical field of medicines, and particularly provides a solid dispersion as well as a preparation method and application thereof. The solid dispersion comprises a carrier material, and further comprises quercetagetin and phospholipid, the mass ratio of the quercetagetin to the phospholipid is 1: (0.3-1.5), and the carrier material comprises one or more of a hydrophilic polymer and a pH-dependent polymer. Wherein the quercetagetin and the phospholipid are combined through an intermolecular force, so that the quercetagetin obtains a lipid material similar to a cell membrane structure, a cell membrane bionic phospholipid compound is formed, the cell membrane bionic phospholipid compound can be naturally compatible with an upper wall cell membrane of a small intestine, and the permeation transmembrane capability of the quercetagetin is better promoted; the quercetagetin is added into the solid dispersion, so that more quercetagetin can enter systemic circulation and lymphatic circulation, and therefore, the solid dispersion can strengthen transmembrane absorption while strengthening dissolution, so that the solid dispersion has high bioavailability.

The invention discloses a preparation method of immunoglobulin composite liposome nanoparticles with a controlled release characteristic, and belongs to the field of food nutrition and functional factors. Cholesterol and sitosterol are creatively used as auxiliary supports of a lecithin liposome skeleton, the stability of an immunoglobulin liposome nanoparticle structure is improved, the slow release property in the simulation effect process is improved, and a pH response type hydrogel film formed based on electrostatic crosslinking is prepared from calcium alginate and chitosan. A more stable double-layer shell-core structure is formed, so that the stability of embedded immune globulin molecules in gastric juice is further improved, and fixed-point slow release in small intestines is realized.

The invention belongs to the field of biological medicines, particularly relates to an oral polypeptide composition system capable of being stably absorbed in gastrointestinal tracts, and particularly discloses an oral polypeptide composition which comprises polypeptide molecules (A), a surfactant (B) and an amino acid single-molecule or double-molecule combination (C), the molecular weight of the peptide medicine used as the medicine in the oral polypeptide composition is in the range of 0.1 kDa to 20 kDa. The acting part of the composition system is small intestine or large intestine; the stability and absorbability of the polypeptide composition in gastrointestinal tracts are obviously improved and enhanced.

The invention relates to composite hydrogel for tissue repair as well as a preparation method and application of the composite hydrogel. The composite hydrogel is prepared from a methacrylated acellular matrix, nano clay (LAP), a photoinitiator, carboxymethyl chitosan (CMCS) and water. The acellular matrix is modified through methylacryloylation, and a polymer network is reinforced by combining nano-clay, so that the mechanical strength is improved; and carboxymethyl chitosan adjusts the degradation rate, constructs a pore structure and endows antibacterial and anti-inflammatory functions. The preparation method comprises the following steps: dissolving the methacrylated acellular matrix in the PBS containing the photoinitiator, dissolving the carboxymethyl chitosan in ultrapure water, mixing, and carrying out illumination cross-linking curing. When the composite hydrogel is applied to small intestine tissue engineering, a small intestine defect part can be filled with the composite hydrogel, photo-crosslinking curing is performed to form a stent, the degradation period is matched with the small intestine regeneration period, and the antibacterial rate is gt; the cell toxicity is 0 level, a good microenvironment can be provided for cells, tissue repair can be promoted, and the compound can also be used for preparing pharmaceutical compositions for treating small intestine related diseases.

The invention belongs to the technical field of medicine, and particularly relates to a medicine for treating or preventing chicken coccidiosis and chicken necrotic enteritis and application, the medicine is chaulmoogratree seed, and can be in the form of medicinal material powder or chaulmoogratree seed extract. The traditional Chinese medicine composition can be used for preventing and treating chicken coccidiosis diseases, reducing the death rate of broilers with necrotic enteritis and intestinal lesions of necrotic enteritis, effectively improving chicken necrotic enteritis and has a good popularization and application prospect in the aspect of preventing and treating chicken necrotic enteritis diseases; the traditional Chinese medicine composition has a good treatment effect on mixed infection diseases of small intestine coccidiosis and clostridium.

The invention provides a preparation method of a Witzia ciliaris IOB502 microbial inoculum and an application of the Witzia ciliaris IOB502 microbial inoculum in the aspect of recovering intestinal motility, the Witzia ciliaris IOB502 microbial inoculum is prepared by adopting a method of carrying out low-oxygen stress staged fermentation on chickpeas by adopting the Witzia ciliaris IOB502, and the generation of vitamins B1 and B2 can be promoted. The microbial inoculum does not affect physiological development of important organs such as liver, spleen and small intestine of mice, can improve defecation symptoms of the mice with constipation, increase defecation times and water content of excrement, improve intestinal movement of the mice with constipation, promote smooth passage of intestinal contents, effectively improve colon injury of the mice with constipation, and improve the constipation rate of the mice with constipation. Comprising mucous membrane layer thinning and mucus secretion reduction.

The invention relates to the technical field of empty capsules, in particular to a production process of enteric plant empty capsules. The preparation method comprises the following steps: firstly, taking hydroxypropyl methylcellulose as a main material, taking carrageenan, Tween 80 and sodium alginate as auxiliary materials, mixing the main material, the auxiliary materials and water, and carrying out glue dipping, forming, drying, demolding and cutting processes to obtain an empty capsule; the preparation method comprises the following steps: modifying chitosan by adopting sodium palmitate, so as to obtain chitosan-palmitate with hydrophobic property; and mixing the chitosan-palmitate with the hydroxypropyl methylcellulose acetate succinate to prepare a coating solution, and coating the hollow capsule to obtain a finished product. The prepared enteric plant empty capsule is high in yield, low in moisture absorption rate and long in disintegration time in gastric acid, it is ensured that effective components are released on the upper portion of the small intestine, and the absorption efficiency is improved.

The invention relates to the technical field of medicines, and discloses a peptide-containing composition for improving human immunity and a preparation method thereof. The peptide-containing composition is prepared by mixing the following components: an active polypeptide liposome, an antioxidant, a sweetening agent and a flocculating agent according to a ratio of (8-25): (1-3): (2-4): 1, so as to obtain the peptide-containing composition, wherein the active polypeptide liposome, the antioxidant, the sweetening agent and the flocculating agent are mixed according to a ratio of (8-25): (1-3): (2-4): 1. The active polypeptide liposome is granular and has a double-layer embedding structure; the active polypeptide liposome comprises the following components in percentage by mass: 60%-80% of polypeptide concentrated solution, 10%-40% of amino acid, 5%-30% of vitamin and 5%-18% of calcium. The peptide-containing composition is an oral liquid preparation and is good in palatability, polypeptide active ingredients are not affected by stomach digestion and can be fully released in small intestines, the absorbance of the polypeptide active ingredients in a human body is improved, and therefore the health care effect is enhanced.

The invention provides a rutin-modified soybean protein isolate-pectin-genipin nano-particle carrier and a preparation method of the rutin-modified soybean protein isolate-pectin-genipin nano-particle carrier. The preparation method of the nanoparticle carrier comprises the following steps: preparing a soybean protein isolate solution, a soybean protein isolate solution after pH shift, an aqueous solution containing rutin-modified soybean protein isolate and an aqueous solution containing rutin-modified soybean protein isolate-pectin; the aqueous solution contains rutin-modified soy isolate protein-pectin-genipin, the concentration of the genipin is 0.05 mg / mL, and the rutin-modified soy isolate protein-pectin-genipin nano-particle carrier is prepared from the rutin-modified soy isolate protein-pectin-genipin nano-particle carrier. The invention further provides application of the rutin-modified soy isolate protein-pectin-genipin nanoparticle carrier. The rutin-modified soy isolate protein-pectin-genipin nanoparticle carrier is used for sustained release of gastric drugs and targeted release of drugs in small intestines. According to the preparation method disclosed by the invention, a rutin-modified soybean protein isolate-polysaccharide nanoparticle carrier with a shell-core structure can be formed, gastric acid erosion can be effectively resisted, and the rutin-modified soybean protein isolate-polysaccharide nanoparticle carrier is delivered to small intestines in a targeted manner.

According to the chitosan-coated gamma-cyclodextrin metal organic framework delivery system and the preparation method and application thereof, hippophae rhamnoides polyphenol serving as an active component is efficiently loaded through a hydrophobic cavity of the chitosan-coated gamma-cyclodextrin metal organic framework delivery system, and encapsulation and release of the hippophae rhamnoides polyphenol can be achieved through the hydrophilic surface of the chitosan-coated gamma-cyclodextrin metal organic framework delivery system; chitosan is adopted as a protective layer to coat the cyclodextrin metal organic framework and the sea-buckthorn polyphenol, so that the carrier and the active components are prevented from being damaged by gastric acid and small intestine digestive enzymes, and the sea-buckthorn polyphenol can be accurately positioned to the colon part through the targeted positioning effect of the chitosan, so that the treatment on the colitis is realized, and the treatment effect is good. The invention provides a more effective and safer inflammation treatment means.

The invention discloses a sugarcane polyphenol and mulberry leaf extract compound raw material and application thereof.The sugarcane polyphenol and mulberry leaf extract compound raw material comprises sugarcane polyphenol and mulberry leaf extract, the polyphenol content of the sugarcane polyphenol is larger than or equal to 20%, the DNJ content of the mulberry leaf extract is larger than or equal to 10%, and the concentration of the polyphenol and the DNJ is 0.1-2% after the sugarcane polyphenol and the mulberry leaf extract are compounded; by compounding the sugarcane polyphenol and the mulberry leaf extract, the active and passive transfer effects of glucose in small intestines are effectively blocked, so that the rate of the glucose entering blood is controlled, the blood glucose reaction after carbohydrate food is eaten is reduced, the decomposition and absorption of the intestinal tract to carbohydrates such as starch and disaccharide are delayed, the postprandial blood sugar is stabilized, and the blood sugar content is reduced. By reasonably adjusting the concentration of polyphenols and DNJ in the compound extract to be 0.1-2%, the combination of blocking and dredging can be realized, a synergistic effect is generated, more comprehensive and more stable management of blood sugar is realized, and meanwhile, natural crops are adopted, so that the product quality safety is ensured.

The invention belongs to the technical field of biological medicines, and particularly relates to a composition containing probiotics and application of the composition in regulating intestinal flora. The active polypeptide disclosed by the invention can be directly absorbed and utilized by small intestines without being digested by a human body, is high in absorption speed and high in bioavailability, and can effectively promote growth and reproduction of bifidobacterium and also promote generation of acetic acid. When the active polypeptide is independently used or combined with probiotics, the number recovery of bifidobacteria in intestinal tracts can be promoted, the growth and reproduction of enterobacter can be inhibited, and the flora balance of the intestinal tracts can be maintained.

The invention provides a ruminant rumen bypass coating preparation and a preparation method and application thereof. The rumen bypass coating preparation comprises a core material and a coating, wherein a coating solution for preparing the coating comprises the following components in parts by weight: 8-10 parts of soybean lecithin oil; 2-3 parts of reducing sugar; 18 to 20 parts of grease; the coating liquid is prepared by the following steps: heating and melting 8-10 parts of soybean lecithin oil at the high temperature of 60-90 DEG C, adding 2-3 parts of reducing sugar into a molten reaction pot, stirring until the reducing sugar is molten, and preserving heat at 50 DEG C after the materials react to be brown yellow; and additionally taking 18-20 parts of grease, heating and melting, mixing the material obtained in the previous step with the grease, and uniformly stirring to form a mixed solution, namely the coating solution. According to the invention, the Maillard reaction between lecithin and reducing sugar is utilized to produce a product with good rumen bypass and intestinal release effects, the obtained product has high purity, good quality and high small intestine release rate, the vitality of immune cells is improved, and the disease resistance and stress resistance are enhanced.

The invention discloses a diaphragm electrical stimulation method and a related device, and the method comprises the steps: a gastrointestinal tube provided with a plurality of electrodes is arranged, and the farthest end of the gastrointestinal tube is located in the stomach or the small intestine; the electrode is arranged on the outer surface of the gastrointestinal tube and used for collecting diaphragm electromyographic signals and amplifying the diaphragm electromyographic signals by 1000 times to 5000 times through the differential amplifier; judging whether the diaphragm has a contraction intention and a respiratory reaction according to the diaphragm electromyographic signal so as to determine whether to trigger electrical stimulation; wherein if the diaphragm electromyographic signals are not detected within the preset time or the diaphragm electromyographic signals are weak and cannot cause enough respiratory response, diaphragm electrical stimulation is started to cause enough respiratory response, and diaphragm disuse atrophy is prevented. The electrical stimulation parameters are dynamically adjusted according to the diaphragm electromyographic signals and the respiratory response of the patient, it is ensured that electrical stimulation occurs at the best time and under the best condition, and therefore the treatment effect is improved.