129 results about "Fallopian tube" patented technology

Embodiments of the invention include aerogel implants and methods for making aerogel implants, and methods of implantation of aerogel implants. Such implants are configured to swell in vivo following insertion into a body cavity or lumen, such as a vas deferens or fallopian tube, to provide an occlusion. In embodiments, in vivo swelling results in an aerogel implant (e.g., a rehydrated hydrogel implant) that is dynamically responsive to vessel contraction.

Embodiments of the invention include aerogel implants and methods for making aerogel implants, and methods of implantation of aerogel implants. Such implants are configured to swell in vivo following insertion into a body cavity or lumen, such as a vas deferens or fallopian tube, to provide an occlusion. In embodiments, in vivo swelling results in an aerogel implant (e.g., a rehydrated hydrogel implant) that is dynamically responsive to vessel contraction.

Delivery systems for providing occlusive hydrogels in a tube lumen or void space within the body including but not limited to a reproductive tract such as the vas deferens or fallopian tubes for contraception are described. The delivery systems contain mechanisms that confirm proper placement of the system in the bodily lumen prior to the delivery of the occlusive material. The systems also can contain a confirmatory mechanism that demonstrates the blockage or occlusion in the bodily lumen has been achieved following the deposition of the occlusive material. Another aspect of this application is to provide a removal system that delivers dissolving material, agitates, aspirates, and confirms the patency of the bodily lumen following the removal of the occlusive material if so desired by the patient for the return to fertility.

The present application discloses a gene point mutation mouse model construction method, comprising: by taking T274M mutation on Kcnq2 Exon6 as a target, designing sgRNA and ssODN; selecting a female mouse of a set week age as an ovum donor, injecting a certain dose of serum gonadotropin and human chorionic gonadotropin into the abdominal cavity of the female mouse, then mating the female mouse with a mating male mouse, and collecting zygotes of the mated female mouse; injecting Cas9 protein, ssODN and sgRNA into the pronuclei of the zygotes by means of a microinjection technique, transplanting the zygotes obtained after injection into the ampulla of the fallopian tube of a surrogate female mouse, and obtaining a neonatal mouse after the pregnant female mouse gives birth; respectively designing a pair of identification primers F1, R1 at two ends of a mutation site on the basis of a Kcnq2 gene point mutation site, identifying the neonatal mouse, and screening out a Kcnq2T274M / + point mutant mouse in which T274M mutation is successfully knocked.

The utility model relates to the technical field of fallopian tube dredging devices, in particular to a fallopian tube catheter suite, a guide tube comprises a first tube body and a first connector which are communicated, the first tube body can be inserted into an outer sleeve, and an inner catheter can be inserted into the first tube body from a side connector; the fallopian tube suite can be switched to a first working state when the guide tube is located in the outer sleeve; on the basis of the first working state, when the inner guide pipe is located in the guide pipe, the inner guide pipe can be switched to the second working state; on the basis of the second working state, the guide wire can be switched to the third working state when the guide wire is located in the inner catheter; the fallopian tube catheter suite has the advantages that the fallopian tube catheter suite provides a hardware basis for a series of operations such as fallopian tube radiography, sterilization, dredging, suction and lavage, the functions can be achieved through one suite, and the surgical operation process is greatly simplified.

The present invention relates to the use of small molecule compounds that allosterically inhibit ALC1 (CHD1L), in particular two classes allosteric inhibitors of ALC1 (CHD1L), of Formula (I) and Formula (II), that show a potentiating, preferably additive effect in the treatment of proliferative disease when combined with several classes of cancer drugs, namely inhibitors of Topoisomerase I, Topoisomerase II, ATM, ATR, Wee1, BRD, and MEK, or when combined with mitomycin C, paclitaxel, with ionizing radiation, or with an antibody drug conjugate with a tumor specific antibody conjugated to a TOP1 inhibitor. Furthermore, the present invention relates to said inhibitors of ALC1 of Formula (II) that show a synergistic effect in the treatment of pancreatic cancer or fallopian tube cancer when combined with a PARP inhibitor (Poly(ADP-ribose)-Polymerase inhibitor (PARPi)). By being synergistic with the function of said cancer drugs, said ALC1 inhibitors, in particular those of Formula (I) and Formula (II), potentiate the cancer cell killing properties of the aforementioned cancer drugs, in particular enabling therapeutic approaches where any of the aforementioned inhibitors is already used as part of the standard of care.

Methods and compositions for treating cancer (e.g., ovarian, fallopian tube, uterine, cervical, vaginal, vulvar, or peritoneal cancer) are disclosed. The methods include intermittent administration of a glucocorticoid receptor modulator (GRM), such as a non-steroidal GRM (e.g., relacorilant), which may be orally administered, along with a cancer chemotherapy agent (such as, e.g., bevacizumab) to the patient. The GRM may be administered: at intervals separated by at least one day without GRM administration; by a schedule linked to the cancer chemotherapy schedule (e.g., a weekly chemotherapy regimen); the day of, or the day before, or the day after, chemotherapy administration; by combinations thereof; and / or on other days. Ovarian cancer patients receiving intermittent relacorilant administration along with nab-paclitaxel administration had improved overall survival, improved progression free survival, improved duration of response, and other benefits as compared to patients not receiving relacorilant while receiving nab-paclitaxel.

The invention pertains to a foamable, echolucent composition, wherein the composition comprises (i) a gelling agent, (ii) water, and (iii) between 0.005 and 20 vol.% oil based on total volume of the composition, wherein the composition turns echogenic when foamed, and preferably has a viscosity of at least 1500 cP. Also, the invention pertains to a foamed, echogenic, image-enhancing composition, wherein the composition comprises (i) a gelling agent, (ii) water, (iii) between 0.005 and 20 vol.% oil based on total volume of the composition, and (iv) air or gas bubbles, wherein the composition preferably has a viscosity of less than 1500 cP, most preferably 50 – 500 cP.

The invention discloses a laying hen metritis molding agent as well as a preparation method and application thereof. The molding agent comprises the following components: a lipopolysaccharide solution and a phenol solution in a volume ratio of (0.5-1.5): (0.5-1.5). According to the method, lipopolysaccharide and a phenol solution are used as a molding reagent, and the lipopolysaccharide and the phenol solution act together, so that inflammation can be caused while the mucosal barrier of the uterus part of the fallopian tube of the laying hen is damaged, and the problems that a pathogenic microorganism molding agent has no effect and a chemical reagent molding agent is separated from actual production are solved; according to the method, inflammatory reaction can be rapidly generated, typical symptoms of laying hen hysteritis appear, the molding dosage is accurately mastered, the repeatability is improved, the method is not easily influenced by microbial toxicity and organism immunity, pollution caused by pathogenic bacteria is reduced, and the requirement for a test site is lowered.

The invention relates to a cherry valley duck PLV virus vaccine as well as a preparation method and application thereof, and belongs to the technical field of virus immunity. The vaccine is prepared by taking a Parry's Lagon virus (PLV) virus strain PLV-20155 as an immunogen, the strain is preserved in the China General Microbiological Culture Collection Center (CGMCC), and the preservation number is CGMCC NO.46296. The invention further discloses a preparation method of the vaccine. The vaccine is a PLV-20155 virus inactivated vaccine, and the preparation method of the vaccine comprises the following steps: inoculating the PLV-20155 virus into an SPF chick embryo for propagation, harvesting a virus liquid, inactivating with formaldehyde, verifying safety, emulsifying with white oil to prepare the vaccine and the like. In addition, the vaccine disclosed by the invention can be used for effectively preventing diseases such as laying rate reduction, follicle necrosis and fallopian tube atrophy of the cherry valley ducks caused by the PLV-20155 virus, and the economic benefit of breeding is remarkably improved.

Systems, methods and devices for endoluminal surgical procedures include a robotic surgical systems adapted and configured to perform lower and upper gastrointestinal endoluminal submucosal dissection (ESD), endoluminal ‎sleeve gastroplasty (ESG), trans-oral endoluminal fundoplication, bariatric endoluminal antral myotomy (BEAM), peroral endoluminal myotomy (POEM), gastroplasty with endoscopic myotomy (GEM), trans-vaginal hysterectomy, trans-vaginal oophorectomy, and trans-vaginal oophoro-salpingectomy. The systems include a physician console, a patient cart and a system controller. The system controller is adapted and configured to receive a plurality of control inputs from ‎each of a plurality of hand control input devices, to process the plurality of control inputs and to ‎transmit a plurality of control outputs to an axial translation actuator, a roll actuator, ‎a steerable overtube controller, a plurality of instrument controllers and a videoscope ‎controller.

The invention discloses a free directional guide visual guide wire mirror device. The device mainly comprises a handheld handle, an imaging optical fiber, an illumination optical fiber, a miniature view finding objective lens group, a photoelectric conversion image acquisition group, a flexible outer sleeve and a front-end free directional guide end, and the outer diameter of the device is smaller than 0.9 mm. And through a unique free directional guiding function, the visual probe can enter a superfine lumen and a narrow part for visual exploration on the premise of not damaging the mucous membrane of the cavity. The endoscope can be applied to medical scenes such as fallopian tube cavity examination, assistance of a duodenoscope in bile duct operation and the like, the application limitation of a traditional endoscope is effectively broken through, ray radiation hazards are reduced, the cross infection risk is reduced, and an innovative technical means is provided for medical diagnosis and treatment.

The present invention provides an embolization device and embolization system. The embolization device includes a spring coil having a storage configuration, an application configuration, and a memory configuration. The memory configuration of the spring coil allows the spring coil to be in the application configuration after being constrained in the fallopian tube. The embolization device of the present invention, with the spring coil as the main structure, is provided with a multi-stage smooth configuration within different length ranges. This ensures that the embolization device can be configured into a supporting segment and a stacking segment after being implanted in the fallopian tube. The multiple supporting segments cooperate to extend deep into the fallopian tube distally, preventing the spring coil from becoming stuck in the fallopian tube, thereby anchoring it in the fallopian tube. The multiple stacking segments collapse and stack into a ball at the proximal end, thereby achieving localized and dense packing of the fallopian tube.

The invention relates to a livestock breeding technology, and discloses a preparation method of a premix for enhancing laying hen production treatment, in the construction of a basic nutrition framework, the construction of a vitamin system is a core project, vitamin A is supplemented by adopting a palmitate form, the stability of the vitamin A in feed processing is ensured, the level of 8000-12000IU should be maintained in each kilogram of feed, and the content of the vitamin A in the feed processing is reduced. According to the fallopian tube mucous membrane composition, the addition amount of the vitamin D3 in the metabolic activity form of 25-hydroxyD3 needs to reach 2000-3000 IU / kg, the vitamin D3 and parathyroid hormone have a synergistic effect, the calcium and phosphorus deposition efficiency can be remarkably improved, particularly, the synergistic effect of B vitamins is worthy of attention, and thiamine (B1) and riboflavin (B2) are compatible according to the proportion of 1: 2. According to the preparation method of the premix for enhancing laying hen production treatment, the growth speed and the laying efficiency of chicken flocks are effectively improved, the eggshell quality is ensured, nutritional diseases such as chondropathy and egg reduction diseases are reduced, and the economic benefits of laying hen breeding are greatly improved.

The utility model relates to the technical field of gynecologic tumor surgery, and discloses a gynecologic tumor surgery model which comprises a uterus model made of hard materials, a first opening and a second opening are arranged on two sides of the uterus model, ovarian models made of elastic materials are arranged on two sides of the uterus model, one end of each ovarian model is inserted into the corresponding second opening, and the other end of each ovarian model is inserted into the corresponding second opening. The two sides of the uterus model are provided with fallopian tube models made of elastic materials, one end of each fallopian tube model is inserted into the corresponding first opening, according to the tumor operation model, multiple models and simulation pieces are installed on the uterus model through multiple connecting structures convenient to disassemble and assemble, all the models and the simulation pieces can be rapidly disassembled and replaced, and the operation efficiency is improved. The operation model can be repeatedly utilized, the whole model simulates the size of the uterus, the material touch feeling is close to the real touch feeling of each organ as much as possible, the model types are complete, various operation simulations can be carried out, the feeling of a doctor during operation simulation is optimized, and the operation level of the doctor can be improved.

The invention discloses a construction method and application of an animal model for HPV (human papillomavirus) pathogenic mechanism research, and belongs to the technical field of animal models. According to the construction method of the HPV fixed-point integration animal model, HPV16 gene knock-in is carried out on the Col1a1 gene locus of a C57BL / 6J mouse through CRISPR / Cas mediated genome engineering. The method comprises the following steps: (1) designing specific gRNA; (2) constructing a knock-in vector Donor vector; and (3) uniformly mixing Cas9 protein, gRNA and a targeting vector Donor vector to obtain an injection compound, performing micro-injection on the injection compound into a mouse fertilized egg, and sending the injection compound back to a pregnant mouse fallopian tube to cultivate offspring so as to generate a gene knock-in mouse. The animal model prepared by the method can be used as a contrast of a cervical cancer precancerous lesion animal model for scientific research.

Compositions, methods, and uses for injecting hydrogels of ablative chemicals are described. The hydrogel is biodegradable and can be formed in situ. The hydrogel is effective to deliver tissue ablative chemicals to a target site. The tissue ablative chemicals delivered by the hydrogel may also be particularly effective for intrauterine ablation (even in the presence of fibroma) or for scar treatment of fallopian tubes by minimally invasive surgery for birth control. The hydrogel may also particularly effectively avoid tissue ablative chemicals from contacting non-target tissue. The hydrogels may be implanted using a variety of delivery carriers, including injections and catheters. The hydrogel may be designed to be limited to a target site for a time of several hours to several days such that target tissue ablation may be performed within a walkable patient. Methods are described for the transcervical placement of an in situ formed hydrogel into the uterus or one or more fallopian tubes.

The invention is suitable for the field of medical imaging, and provides a hysterosalpingography imaging device and method, and the method comprises the following steps: S1, examinee preparation, S2, preparation before imaging, S3, ultrasonic imaging, S4, photoacoustic contrast imaging, and S5, image fusion. According to the imaging method, the photoacoustic imaging technology and the ultrasonic imaging technology are combined, ICG serves as a contrast agent, a high-resolution uterine fallopian tube structure image can be obtained, functional parameters such as blood flow information and blood oxygen information in tissue can be detected through ultrasonic and photoacoustic characteristics, the imaging range is larger by designing a movable area array probe, and the imaging accuracy is improved. The operation is more convenient.

The invention discloses reversible long-acting hydrogel capable of being cured in situ in a human body cavity, the reversible long-acting hydrogel comprises hydrogel and a reversible reagent, after the hydrogel swells, long-acting blocking is achieved, after the reversible reagent is added, the hydrogel is degraded, and reversible recovery is achieved. According to the invention, 10wt%-60wt% of a polyethylene glycol derivative acid solution and 1wt%-10wt% of a polylysine alkaline solution are subjected to a cross-linking effect, and a formed cross-linked network can prevent cells from passing but cannot prevent body fluid and salt ions from passing, so that the long-acting contraception agent can be applied to seminiferous ducts and fallopian tubes to realize a long-acting contraception effect. The hydrogel has a certain degradation period and can meet the requirements of different contraception periods, when a patient has the fertility requirement in advance, a reversible reagent can be injected in situ to degrade the gel to achieve cavity restoration, and the hydrogel is fast in degradation, safe to use and good in biocompatibility.

A tubal sterilization system is described. The system includes a catheter having a first lumen and a second lumen, a footplate or plug deployable from the first lumen, and an adhesive deployable from the second lumen. Also described is a method of tubal sterilization. The method includes the steps of positioning a distal end of a catheter having a first lumen and a second lumen near the distal end of a fallopian tube of a subject, deploying a footplate or plug from the first lumen of the catheter to a long segment of the fallopian tube, and deploying an adhesive from the second lumen of the catheter, such that the adhesive remains proximal to the footplate or plug. Also described is a method of sterilization for a male subject.

The invention provides a construction method and application of a chicken fallopian tube embolism model, and belongs to the technical field of animal infection models. The invention provides a construction method of a chicken fallopian tube embolism model based on multi-pathogen infection. The mycoplasma synoviae, the infectious bronchitis virus and the riemerella anatipestifer are utilized to infect the chicken, and the clinical typical salpingemphasis pathological process including cheese-like substance accumulation in a salpingemphasis cavity, serious abdominal air sacculitis complications and related tissue inflammation changes can be accurately reproduced. The model constructed by the invention is high in morbidity, and is suitable for epidemic disease pathogenesis research, drug screening and vaccine potency test. Compared with an existing single pathogen infection model, the model is closer to a clinical reality multi-pathogen cooperative infection scene, and the blank of a standardized multi-pathogen mixed infection induced fallopian tube embolism animal model is filled up.

The invention discloses an intelligent analysis method and system for a contrast image based on generative anti-fact interpretation. The method comprises the following steps: acquiring paired medical image data of an early contrast agent filling period and a late contrast agent dispersion period in a fallopian tube; extracting and calculating a difference value between the late image feature and the early image feature, and constructing a dynamic feature; early image spatial features are extracted, a multi-scale gating fusion up-sampling mechanism is designed, the spatial features and dynamic features are fused step by step, reconstruction of the spatial features is dynamically guided, and an anti-fact image is generated while structural continuity is guaranteed; quantizing a pixel level difference of the generated anti-fact image from the late image; by quantizing the pixel-level difference between the real state and the ideal state and visually presenting the difference part, the diagnosis of a doctor is better assisted, and the efficiency and the accuracy of clinical diagnosis are improved.

The invention discloses a micro-fluidic chip device for a sperm climbing experiment and an experiment method thereof.The device comprises a micro-fluidic chip body and a temperature control device, a sperm sampling pool of the micro-fluidic chip body is filled with a human sperm sample, and the sperm sampling pool is communicated with a sperm enrichment pool through a sperm filtering channel; the sperm climbing channel is vertically fixed at the central position of the sperm enrichment pool through a lap joint block; a treating fluid sample inlet is formed in the top of the sperm climbing channel; a first sperm sampling opening, a second sperm sampling opening and a third sperm sampling opening are sequentially formed in the side surface of the sperm climbing channel; the temperature control device comprises a heater and a temperature controller, and the heater is arranged at the bottom of the sperm enrichment pool and used for maintaining the stability of the temperature microenvironment in the micro-fluidic chip main body; the microenvironment of the fallopian tube is accurately simulated through bionic design, and physiological support is provided for sperm activity evaluation.

The utility model provides a radiography infusion connecting pipe and infusion pump pipeline switching device, including main conduit, branch pipe and pipe joint, branch pipe is aslant communicated with one side of main conduit surface, the top end of main conduit is communicated with first threaded pipe head, branch pipe far away from main conduit far away from one end of main conduit is communicated with second threaded pipe head, and the pipe joint is communicated with the first threaded pipe head. Compared with the prior art, the radiography liquid infusion device has the advantages that water flow pumped by an external infusion pump can impact the cross-shaped notch of the silica gel sealing layer open, an infusion channel is opened, radiography liquid is normally conveyed, when the infusion pump stops conveying, the cross-shaped notch of the silica gel sealing layer can be automatically closed due to the deformation recovery capacity of silica gel, and therefore the radiography liquid can be normally conveyed. By means of the structure, a channel between liquid at the liquid outlet pipe and the conveying pipe can be blocked, the phenomenon that the liquid in the liquid outlet pipe flows back is avoided, liquid medicine pollution generated in the uterus and fallopian tube radiography process is reduced, and therefore the use safety of medical instruments is effectively improved.

The application discloses an oviduct radiography recanalization device, which comprises a double-cavity tube, a guide tube and a guide wire, wherein the double-cavity tube is provided with a liquid injection cavity and a guide cavity, a balloon is arranged on the outer wall of the double-cavity tube and is communicated with the liquid injection cavity, the guide tube is movably arranged in the guide cavity, the guide wire is movably arranged in the guide tube and the distal end of the guide wire can be extended from the distal end of the guide tube, and the recanalization catheter is slidably sleeved outside the guide wire and is provided with a preformed deformation section, wherein the deformation section comprises a first arc-shaped section and a second arc-shaped section.

The utility model relates to an oviduct angiographic catheter. The fallopian tube liquid injection device comprises an installation head, one end of the installation head is fixedly connected with an outer catheter, a liquid injection head is fixedly connected into the installation head, one end, close to the outer catheter, of the liquid injection head is fixedly connected with an inner catheter, and the inner catheter penetrates through the outer catheter. Then an external inflator is used for inflating through an inflation head, so that inflation of the balloon is achieved, the balloon expands after inflation is completed, the fallopian tube is sealed, contrast agents are prevented from flowing out of the uterus, then a rotary knob is rotated, the rotary knob drives a threaded rod to rotate during rotation, the threaded rod drives a rubber pressing plate to move downwards in the rotation process, and the rubber pressing plate is driven to move downwards during rotation. And the inflation tube is sealed after being extruded, so that airflow in the balloon is prevented from flowing back from the inflation tube, and the balloon is ensured to have a good sealing effect on the fallopian tube.

The present invention provides a fallopian tube diagnosis and dredging device, comprising an outer sheath, an inner catheter movably arranged in the outer sheath, a pressure sensing guide wire movably arranged in the inner catheter, a pressure sensor fixed at the distal end of the pressure sensing guide wire, a liquid passage tube, a flow pump installed on the liquid passage tube, a state indication panel and a controller, wherein the distal end of the outer sheath has a sealing fixed section and a distal through hole, the inner catheter has a liquid passage cavity connected to the liquid passage tube, and a first liquid passage hole opened on the distal end surface of the inner catheter and connected to the liquid passage cavity, and the pressure sensing guide wire has a guide wire head end distributed on the distal side of the pressure sensor; when the inner catheter and the guide wire head end are both located in the outer sheath, the first liquid passage hole is connected to the distal through hole. The operator finds the best insertion angle according to the pressure value fed back by the pressure sensor displayed on the state indication panel to avoid damaging the fallopian tube; the state of the fallopian tube is accurately determined according to the controller obtaining the liquid flow fed back by the flow pump and the liquid pressure fed back by the pressure sensor.

1. The name of this design product: Teaching model body (uterine cavity and fallopian tube model). 2. Purpose of this design product: This design product is used for teaching demonstration. 3. The key point of the design of this product lies in its shape. 4. The picture or photo that best illustrates the design points: Stereoscopic drawing 1.

Methods and systems are provided for trans-cervical delivery of agents for various purposes, including contraception and tubal patency evaluation. The trans-cervical delivery system comprises at least one port: a tubular shaft coupled to the port, the tubular shaft including at least one hollow channel traversing an interior length of the tubular shaft; and an agent delivery end coupled to the tubular shaft, the agent delivery end including at least one flexible catheter and a plug. The trans-cervical delivery system of the present disclosure integrates a pre-formed wire frame into the agent delivery end that enables self-positioning of the catheter and assists in gaining precise access to the cornual regions of a uterus by an operator. In one example, the trans-cervical delivery system may be utilized for selective delivery of a foam agent to fallopian tubes non-surgically.

This invention discloses a visual guidewire recanalization device for unblocking fallopian tubes, comprising a guidewire body, a sheath, a connecting handle, and a propulsion control system. The core of the guidewire body has an eccentric channel offset from its axis, and the inner wall of the eccentric channel has an inner spiral guide groove. An imaging fiber bundle and an illumination fiber are disposed within the inner spiral guide groove. A spiral layer is sleeved outside the core, and the outer surface of the spiral layer has continuous micro-spiral grooves extending from the proximal end to the distal end. The sheath is sleeved outside the guidewire body. The connecting handle has an irrigation adjustment mechanism communicating with the micro-spiral grooves. The propulsion control system is connected to the proximal end of the spiral layer and is used to drive the rotation and axial movement of the guidewire body. This visual guidewire recanalization device for unblocking fallopian tubes integrates visualization functions and achieves continuous and synchronous fluid irrigation without increasing or even decreasing the guidewire diameter, thereby improving the unblocking effect while maximizing the safety and controllability of the operation.