32 results about "Fallopian tube" patented technology

The invention pertains to a foamable, echolucent composition, wherein the composition comprises (i) a gelling agent, (ii) water, and (iii) between 0.005 and 20 vol.% oil based on total volume of the composition, wherein the composition turns echogenic when foamed, and preferably has a viscosity of at least 1500 cP. Also, the invention pertains to a foamed, echogenic, image-enhancing composition, wherein the composition comprises (i) a gelling agent, (ii) water, (iii) between 0.005 and 20 vol.% oil based on total volume of the composition, and (iv) air or gas bubbles, wherein the composition preferably has a viscosity of less than 1500 cP, most preferably 50 – 500 cP.

The invention provides a construction method and application of a chicken fallopian tube embolism model, and belongs to the technical field of animal infection models. The invention provides a construction method of a chicken fallopian tube embolism model based on multi-pathogen infection. The mycoplasma synoviae, the infectious bronchitis virus and the riemerella anatipestifer are utilized to infect the chicken, and the clinical typical salpingemphasis pathological process including cheese-like substance accumulation in a salpingemphasis cavity, serious abdominal air sacculitis complications and related tissue inflammation changes can be accurately reproduced. The model constructed by the invention is high in morbidity, and is suitable for epidemic disease pathogenesis research, drug screening and vaccine potency test. Compared with an existing single pathogen infection model, the model is closer to a clinical reality multi-pathogen cooperative infection scene, and the blank of a standardized multi-pathogen mixed infection induced fallopian tube embolism animal model is filled up.

The application discloses an oviduct radiography recanalization device, which comprises a double-cavity tube, a guide tube and a guide wire, wherein the double-cavity tube is provided with a liquid injection cavity and a guide cavity, a balloon is arranged on the outer wall of the double-cavity tube and is communicated with the liquid injection cavity, the guide tube is movably arranged in the guide cavity, the guide wire is movably arranged in the guide tube and the distal end of the guide wire can be extended from the distal end of the guide tube, and the recanalization catheter is slidably sleeved outside the guide wire and is provided with a preformed deformation section, wherein the deformation section comprises a first arc-shaped section and a second arc-shaped section.

Methods and systems are provided for trans-cervical delivery of agents for various purposes, including contraception and tubal patency evaluation. The trans-cervical delivery system comprises at least one port: a tubular shaft coupled to the port, the tubular shaft including at least one hollow channel traversing an interior length of the tubular shaft; and an agent delivery end coupled to the tubular shaft, the agent delivery end including at least one flexible catheter and a plug. The trans-cervical delivery system of the present disclosure integrates a pre-formed wire frame into the agent delivery end that enables self-positioning of the catheter and assists in gaining precise access to the cornual regions of a uterus by an operator. In one example, the trans-cervical delivery system may be utilized for selective delivery of a foam agent to fallopian tubes non-surgically.

This invention discloses a visual guidewire recanalization device for unblocking fallopian tubes, comprising a guidewire body, a sheath, a connecting handle, and a propulsion control system. The core of the guidewire body has an eccentric channel offset from its axis, and the inner wall of the eccentric channel has an inner spiral guide groove. An imaging fiber bundle and an illumination fiber are disposed within the inner spiral guide groove. A spiral layer is sleeved outside the core, and the outer surface of the spiral layer has continuous micro-spiral grooves extending from the proximal end to the distal end. The sheath is sleeved outside the guidewire body. The connecting handle has an irrigation adjustment mechanism communicating with the micro-spiral grooves. The propulsion control system is connected to the proximal end of the spiral layer and is used to drive the rotation and axial movement of the guidewire body. This visual guidewire recanalization device for unblocking fallopian tubes integrates visualization functions and achieves continuous and synchronous fluid irrigation without increasing or even decreasing the guidewire diameter, thereby improving the unblocking effect while maximizing the safety and controllability of the operation.

To provide uses of pertuzumab, which is a first in-class HER2 dimerization inhibitors, and articles of manufacture comprising the same.SOLUTION: A method for extending progression free survival in a population of HER2 + breast carcinoma patients; a method for combining two HER2 antibodies to treat HER2 + breast carcinoma without increasing cardiotoxicity; a method for treating early HER2 + breast carcinoma; a method for treating HER2 + breast carcinoma by co-administering a mixture of pertuzumab and trastuzumab from the same I. v. bag; a method for treating HER2 + metastatic gastric carcinoma; a method for treating HER2 + breast carcinoma with pertuzumab, trastuzumab and vinorelbine; Methods for treating HER2 positive breast cancers with trastuzumab and aromatase inhibitors; and methods for treating low HER3 ovarian, primary peritoneal, or fallopian tube cancers are provided.SELECTED DRAWING: None

The invention discloses a traditional Chinese medicine composition for treating infertility, which is prepared from the following raw materials: radix rehmanniae recen, radix paeoniae alba, turtle shell, cortex moutan, peach kernel, ginseng, radix glehniae, medlar, oyster, rhizoma cyperi, radix curcumae, astragalus membranaceus, angelica sinensis, rhizoma anemarrhenae, golden cypress, lotus seed, rhizoma atractylodis macrocephalae, pericarpium citri reticulatae, chicken's gizzard-membrane, radix bupleuri, tetrapanax papyriferus, donkey-hide gelatin, eucommia ulmoides and deer glue. Spleen tonifying, blood nourishing, phlegm reducing and dampness clearing; the effects of soothing liver-qi stagnation, promoting qi and activating blood are achieved; qi is benefited, blood is nourished, and Zhongzhou is promoted to regenerate Qi and blood; promoting blood circulation to remove blood stasis and dredging Chong and Ren qi; the traditional Chinese medicine composition has the effects of clearing heat, promoting diuresis, eliminating dampness and reducing phlegm, can achieve sufficient qi and blood of liver and kidney and smooth Chong and Ren channels, has a good treatment effect on male and female infertility caused by various reasons, and is particularly suitable for female infertility caused by kidney deficiency, weakness, fallopian tube blockage, cold uterus, kidney deficiency type ovulation disorder, obesity, stasis, weakness, blood deficiency and the like; and the traditional Chinese medicine composition is also suitable for male infertility caused by cold sperm, rare sperm, oligospermia and necrospermia due to kidney deficiency.

The present invention addresses the problem of providing a method for operating an FT catheter whereby treatment can be accurately performed even if an operator is not an experienced operator but an operator having a certain degree of skill. The FT catheter (1) is provided with an outer tube (10), an inner tube (20), a fallopian tube lens (30), and a balloon (40). The target site (101) is gradually expanded by repeating the following steps: a first step in which the distal end of the balloon (40) is brought into contact with the target site (101) by pressurizing the balloon (40) and moving the inner tube (20) toward the distal end side; a second step of moving the fallopian tube lens (30) to the rear end side; a third step of further pressurizing the balloon (40) to bring the outer peripheries of the balloons (40) into contact with each other; a fourth step of moving the fallopian tube lens (30) to the tip side and further expanding the balloon (40) to expand the target site; and a fifth step of reducing the pressure of the balloon (40) to reduce the protrusion (41) of the balloon (40).

The utility model discloses a fallopian tube interventional therapy suite, which relates to the field of fallopian tube interventional therapy and comprises an outer sleeve, a guide nozzle is integrally formed at one end of the outer sleeve, an inner cavity of the guide nozzle is communicated with an inner cavity of the outer sleeve, a transition conical surface is formed at the connection position of one end of the guide nozzle and the outer sleeve, and the transition conical surface is communicated with the guide nozzle. A balloon is integrally formed on the outer wall of the other end of the outer sleeve, an inner sleeve is inserted into the inner wall of the outer sleeve, a corrugated pipe is fixedly connected to one end of the inner sleeve, a straight pipe is fixedly connected to one end of the corrugated pipe, and a wire feeding assembly is connected to one side of the inner wall of the inner sleeve, one side of the inner wall of the corrugated pipe and one side of the inner wall of the straight pipe. A memory assembly is connected to one side of the inner wall of each of the inner sleeve, the corrugated pipe and the straight pipe. By arranging the wire feeding assembly and the memory assembly, the angle of the straight pipe can be actively adjusted by medical staff, the adjusting process is convenient, and the applicability is further improved.

To provide a vibrating endoscopic catheter for suitable tubal advancement.SOLUTION: A falloposcope intended for use with a hysteroscope to access a patient's fallopian tube, image the fallopian tube, and collect a sample from the fallopian tube includes a cannula having an angled tip oriented to engage the ostium of the fallopian tube when the cannula is trans-cervically introduced into the uterus of the patient through the hysteroscope. The catheter has a distal viewing tip configured to be advanced from the distal end of the cannula through the cervical os and into the uterus of the patient. The viewing chamber has a wide proximal end that is attached to the distal viewing tip of the catheter, and the viewing chamber is at least partially transparent and typically tapers distally in order to provide a clear viewing area for the endoscope as well as atraumatic advancement into the fallopian tube.SELECTED DRAWING: Figure 6

This invention relates to the use of small molecule compounds that allosterically inhibit ALC1 (CHD1L), particularly two classes of ALC1 (CHD1L) allosteric inhibitors of formulas (I) and (II). When combined with inhibitors of several classes of cancer drugs, namely topoisomerase I, topoisomerase II, ATM, ATR, Wee1, BRD, and MEK, or when combined with mitomycin C, paclitaxel, ionizing radiation, or antibody-drug conjugates having tumor-specific antibodies conjugated to TOP1 inhibitors, the small molecule compounds and the allosteric inhibitors exhibit enhancing, preferably additive, effects in the treatment of proliferative diseases. Furthermore, this invention relates to the ALC1 inhibitor of formula (II), which, when combined with PARP inhibitors (poly(ADP-ribose)-polymerase inhibitors (PARPi)), exhibit synergistic effects in the treatment of pancreatic cancer or fallopian tube cancer. By synergizing with the functions of the aforementioned cancer drugs, the ALC1 inhibitors, particularly those of formulas (I) and (II) that enhance the cancer cell killing properties of the aforementioned cancer drugs, are particularly capable of achieving treatments in which any of the aforementioned inhibitors have already been used as part of standard care.

The utility model relates to the technical field of medical instruments, and provides an endometrium hot steam ablation uterine cavity pressure relief device and steam ablation equipment, the pressure relief device comprises a pressure relief valve body, a valve assembly and a return elastic piece, and the pressure relief valve body is provided with a pressure relief valve cavity, a pressure relief inlet and a pressure relief outlet; the valve assembly can move relative to the pressure relief valve cavity so as to be switched between a sealing position and a pressure relief position, the return elastic piece is arranged between the valve assembly and the pressure relief valve body, and the return elastic piece is used for driving the valve assembly to return to the sealing position. When the pressure is larger than the set pressure of the pressure relief device, the valve assembly moves to the pressure relief position, the valve assembly is separated from the pressure relief inlet, and the return elastic piece deforms, so that the pressure relief inlet is communicated with the pressure relief outlet through the pressure relief valve cavity to start the pressure relief work, and the pressure in the uterine cavity is in a normal pressure range; therefore, the risk of tissue injury caused by steam invading the fallopian tube is avoided, and the safety of the steam ablation equipment is greatly improved.

The utility model provides a gynecological intrauterine device placement simulation device with touch feedback, and relates to the technical field of medical equipment. A cervix uteri inlet is formed in the lower portion of the simulated uterine wall, the left side and the right side of the upper portion of the simulated uterine wall are connected with the simulated fallopian tubes, a cavity formed in the simulated uterine wall is an internal uterine cavity, the internal uterine cavity is communicated with the interiors of the fallopian tubes, a contraceptive ring is arranged in the internal uterine cavity, and a miniature pressure sensor is arranged in the simulated uterine wall. The upper side of the simulated uterine wall is connected with a data line, and the data line is connected with an external computer, so that an operator can conveniently analyze whether the touch pressure of the contraceptive ring on the inner wall of the uterus causes injury or aggravated pain to a patient, and the technical skilled and improved of the operator are facilitated; the problem that an existing device basically does not have a touch feedback function is solved.

A method for promoting contraception by placing a contraceptive device within a uterus without blocking fallopian tubes may involve advancing a distal end of a delivery device through a cervix, advancing the contraceptive device comprising an elongate shape memory member out of the distal end of the delivery device and into the uterus, and limiting inferior migration of the contraceptive device within the uterus. Inferior migration may be limited by allowing the contraceptive device to assume a shape, when subjected to pressure that tends to cause a downward migration of the device within the uterus, in which an expandable middle portion of the device is expanded to contact the inner wall of the uterus and thus limit the downward migration of the device.

A falloposcope intended for use with a hysteroscope to access, image, and collect samples from a patient's fallopian tube includes a cannula having an angled tip oriented to engage a fallopian tube os when the cannula is transcervically introduced to a patient's uterus through the hysteroscope. The catheter has a distal viewing tip configured to be advanced from a distal end of the cannula into the patient's uterus through a cervical os. A viewing chamber has a wide proximal end attached to the distal viewing tip of the catheter, and the viewing chamber is at least partially transparent and typically tapers in a distal direction to provide a clear viewing zone for the endoscope as well as atraumatic advancement into the fallopian tube.

Disclosed herein are methods of making and using cyanoacrylate compositions comprising one or more cyanoacrylates, a high level of at least one stabilizing agent and at least one free-radical polymerization inhibitor. Methods disclosed comprise making such compositions and using such compositions, for example, for occluding conduits such as fallopian tubes.

A system for treating a female patient to promote pregnancy, comprising a restriction device configured to restrict and release a patient's fallopian tubes post-operatively.SOLUTION: The system of the present invention allows eggs from an ovary to be retained in the oviduct to avoid pregnancy. A restriction device is placed over the two oviducts to restrict and release the oviducts, thereby retaining the eggs as described above.SELECTED DRAWING: Figure 1A

Disclosed herein are methods of making and using cyanoacrylate compositions comprising one or more cyanoacrylates, a high level of at least one stabilizing agent and at least one free-radical polymerization inhibitor. Methods disclosed comprise making such compositions and using such compositions, for example, for occluding conduits such as fallopian tubes.

The invention relates to the technical field of gynecological minimally invasive diagnosis and treatment instruments, and discloses a uterus and abdomen combined examination integrated hysteroscope soft lens which comprises an optical flexible lens body, a biopsy forceps assembly and an optical imaging assembly. A through working channel is formed in the flexible endoscope body, and the biopsy forceps assembly is arranged in the working channel in a penetrating mode. The optical imaging assembly is fixedly arranged at the front end of the flexible hysteroscope body, the flexible hysteroscope body is of a long-strip-shaped structure capable of being bent by 360 degrees, the problems that an existing hysteroscope is limited in probing range, single in function and the like are effectively solved, the flexible hysteroscope body can be bent by 360 degrees and is matched with the specification of penetrating through a fallopian tube to enter an abdominal cavity, and the flexible hysteroscope body can be bent by 360 degrees and is suitable for being used as a flexible hysteroscope. The uterus and abdomen integrated continuous exploration is realized; the working channel is matched with the biopsy forceps assembly to achieve immediate and accurate biopsy, the optical imaging assembly is clear in imaging and assists in lesion recognition, the operation part is convenient and safe in design, multi-part diagnosis and treatment can be completed through one-time operation, efficiency and diagnosis accuracy are improved, and patient wounds and medical cost are reduced.

The invention discloses a method for researching the relation between intestinal colonization and oviduct edema after chlamydia genital tract infection and application, and belongs to the technical field of biological medicine. The invention provides a complete and standardized research system which can be used for researching the relationship between intestinal colonization and oviduct edema after chlamydia genital tract infection; the provided method reveals for the first time that chlamydia genital tract infection is colonized in intestinal tracts and has an inevitable relation with the formation of lasting and stable oedema of fallopian tubes, and a new direction is provided for prevention and treatment of oedema of fallopian tubes induced by chlamydia genital tract infection; therefore, the method provided by the invention can be used for researching the relationship between chlamydia intestinal colonization and oviduct edema, and also has a reference value for other similar researches; the invention also provides a group of preparations which can be used for diagnosis and / or risk prediction and / or prevention and / or treatment of fallopian tube edema induced by chlamydia genital tract infection, and the preparations are symbolic flora obtained by identification with the method provided by the invention.

The invention, which relates to the technical field of medical image analysis, discloses a deep learning-based image analysis system for the obstetrics and gynecology department, comprising a feature extraction module, a region division module, a feature analysis module, an anomaly evaluation module and a visual output module. Multi-scale feature extraction is carried out on medical images of the obstetrics and gynecology department through a multi-resolution convolutional neural network, multi-scale features are integrated by adopting a cross-resolution fusion operation and an adaptive resolution adjustment operator, and accurate region division is carried out on the uterus, the ovary and the fallopian tube through semantic segmentation and morphological screening rules. An improved parallel attention structure is introduced to enhance the feature description capability, an abnormal index is generated based on a local feature quantity and discreteness measurement, and a visual analysis result is generated through color mapping, thermodynamic diagram superposition and a highlight display technology. According to the method, the detection rate and the diagnosis precision of the tiny lesions in the images of the obstetrics and gynecology department are effectively improved, and end-to-end intelligent analysis from feature extraction to visual output is realized.

This invention relates to the field of medical device technology and discloses a fallopian tube contrast agent injection device with pressure feedback and automatic constant temperature function. The device includes a support, a fixed rod fixedly connected to the top of the support, a placement box rotatably connected to the outside of the fixed rod, and a booster mechanism inside the placement box. This booster mechanism is used to provide secondary boosting of the contrast agent under pressure feedback. A medicine container is fixedly connected to the top of the placement box, a needle is fixedly connected to the top of the placement box, and an infusion tube is fixedly connected to the top of the needle. This invention uses a motor-driven gear transmission to move a lead screw and piston, achieving uniform delivery of the contrast agent. When the pressure is too high, a cylinder switches the gear meshing relationship to reduce the rotation speed and slow down the delivery speed. This improves upon the problems of unstable pressure and excessively fast flow rates in traditional contrast agent delivery methods, which can cause patient discomfort or safety risks. It enhances the stability, controllability, and safety of the contrast agent delivery process and achieves adaptive pressure adjustment.

Compositions, devices, and methods of using one or more hydrogel for contraception are disclosed. In embodiments, the compositions and devices comprise one or more contrast agent, rendering the compositions and devices radiopaque. Included are compositions for an occlusive implant comprising: a multi-arm polyethylene glycol terminated with a thiol crosslinked with a multi-arm polyethylene glycol terminated with a maleimide; and one or more contrast agent. The devices / hydrogel may be used for occlusion of a bodily duct, such as the vas deferens and / or fallopian tubes, for male and female contraception, respectively.

The invention relates to the technical field of medical instruments, and particularly provides a hydrotubation tube for oviduct ultrasound contrast. Comprising an outer catheter body, a liquid filling bag connected to the outer face of the front portion of the outer catheter body in a sealed mode, a front end head with a liquid passing outlet formed in the front end, a non-return sleeve connected between the outer face of the front end head and the front end of a catheter cavity of the outer catheter body in a sealed mode, a liquid filling non-return exhaust piece and a liquid passing catheter body. The other end extends out of the outer catheter; one part of the liquid filling non-return exhaust part is connected outside the outer catheter in a sealing manner and is positioned in the liquid filling bag, and the other part of the liquid filling non-return exhaust part extends out of the catheter cavity; and at least one through hole is formed in the front part of the non-return sleeve and is aligned with the liquid passing outlet. The system is low in cost and easy to use, cervical intubation is easy, and the image identification degree and the examination efficiency can be improved.

The application provides an oviduct auxiliary prediction method based on a large model, and belongs to the technical field of AI assistance, and comprises the following steps: acquiring first data before a patient undergoes oviduct dredging and second data after the patient undergoes oviduct dredging, and taking the data as a group of sample data; based on a multi-modal embedding model, each group of sample data is subjected to data vectorization and stored in a vector database as a basic knowledge base; based on a large model and in combination with the basic knowledge base, preoperative examination results of the current patient before oviduct dredging are analyzed to obtain an auxiliary judgment result; if the current patient undergoes oviduct dredging, then the postoperative examination results of the current patient after oviduct dredging are continuously acquired, and the basic knowledge base is updated in combination with the preoperative examination results. The auxiliary prediction of the current patient is realized, and effective pregnancy guidance is facilitated.

An abdominal cavity transmittal tubal recanalization device, comprising two support structures, each of which comprises a balloon part and a support part arranged outside the balloon part, the support part is supported and maintained in the state of being supported, the support part is absorbable or changes with the size of the balloon part; two delivery tubes, each of which is provided with a support structure, the support structure is close to the inner wall of the delivery tube; a push-out structure, one delivery tube is provided with one push-out structure, the first end of the push-out structure is arranged in the delivery tube, the second end is arranged outside the delivery tube, the push-out structure pushes the support structure in the delivery tube out of the delivery tube; and a butt joint structure for butt joint of the two support structures, the butt joint structure can be a pulling wire arranged on the threading hole of the two support parts. The two support structures are more easily arranged through the abdominal cavity, and the butt joint structure can effectively butt joint the support structures, ensuring the final suturing effect.

The application relates to a medical image analysis method and device based on fallopian tube anatomical segmentation, which comprises the following steps: acquiring a laparoscope image, extracting blood flow direction and velocity information, and generating a blood flow direction graph; dividing the fallopian tube into three regions of an umbrella part, a ampulla part and an isthmus part, extracting and marking the structure edges of the three regions, generating an anatomical structure boundary graph, performing image fusion processing on the blood flow direction graph and the anatomical structure boundary graph, and identifying a blood flow abnormality concentration region; performing image segmentation and pathological feature identification on the blood flow abnormality concentration region, judging whether pathological tissues exist, if yes, marking the region, and generating a prompt information. Through the analysis of the blood flow direction and velocity and the anatomical segmentation of the fallopian tube, the position of a blood point can be accurately identified, the blood flow abnormality region can be found in time, and the doctor can make more accurate and safe decisions in the operation process.

The invention pertains to a foamable, echolucent composition, wherein the composition comprises (i) a gelling agent, (ii) water, and (iii) between 0.005 and 20 vol.% oil based on total volume of the composition, wherein the composition turns echogenic when foamed, and preferably has a viscosity of at least 1500 cP. Also, the invention pertains to a foamed, echogenic, image-enhancing composition, wherein the composition comprises (i) a gelling agent, (ii) water, (iii) between 0.005 and 20 vol.% oil based on total volume of the composition, and (iv) air or gas bubbles, wherein the composition preferably has a viscosity of less than 1500 cP, most preferably 50 – 500 cP.

The utility model discloses a fallopian tube angiography catheter with good insertion stability, which comprises a catheter, a plugging head arranged at the front end of the catheter, a first drainage cavity arranged in the catheter, a second drainage cavity arranged in the plugging head, an insertion tube arranged at the front end of the plugging head, and a rear port of the second drainage cavity in butt joint with the front end of the first drainage cavity. A plurality of annular fins located in the radial direction are arranged on the side face of the periphery of the insertion pipe at intervals in the length direction. When the insertion tube is inserted into a cervical canal for use, the annular fins play a role in supporting and tensioning the inner side wall surface of the cervical canal, so that the frictional resistance between the insertion tube and the cervical canal is remarkably improved, and the slipping phenomenon of the angiographic catheter in the use process is effectively prevented; in the radiography operation process, medical operators do not need to hold the radiography catheter in the whole process or do not need to additionally arrange a fixing support used for supporting the radiography catheter, so that the radiography operation difficulty of the uterus fallopian tube is effectively reduced, meanwhile, the physical strength of the medical operators is saved, and the use experience effect is good.

The invention relates to the technical field of poultry breeding and veterinary drugs, and discloses a pharmaceutical composition for preventing salpingitis of laying hens, which is prepared from astragalus membranaceus, salvia miltiorrhiza, silymarin, oyster, humifuse euphorbia herb, cistanche, angelica sinensis, parsley, geranium wilfordii and a compound enzyme preparation. Wherein the complex enzyme preparation is composed of lysozyme and glucose oxidase, and the preparation method comprises the following steps: firstly, carrying out low-temperature superfine grinding on the traditional Chinese medicine components, and then carrying out multi-stage mixing on the traditional Chinese medicine components and the complex enzyme preparation. The compound enzyme preparation is used for regulating the intestinal micro-ecology, reducing the load of pathogenic bacteria and blocking the ascending infection of the fallopian tube; the traditional Chinese medicine components are used for clearing away heat and toxic materials, astringing, repairing, tonifying qi and activating blood and promoting fallopian tube mucosa repair. The composition can effectively reduce the occurrence rate of salpingitis of laying hens and improve the eggshell quality, and the preparation process avoids enzyme preparation inactivation and ensures the biological activity and stability of the product.