81 results about "Thiamine" patented technology

The invention discloses a fermentation medium for regulating and controlling a clostridium aerovorans target product and a fermentation method of the clostridium aerovorans target product. The medium comprises a basic component and a regulating component, the basic components comprise ammonium chloride, potassium chloride, magnesium sulfate heptahydrate, sodium chloride, monopotassium phosphate, yeast powder, calcium chloride dihydrate, sodium selenite, nickel chloride hexahydrate, biotin, folic acid, pyridoxine hydrochloride, thiamine, riboflavin, nicotinic acid, D-calcium pantothenate, cobalamin, para aminobenzoic acid and lipoic acid; the adjusting component comprises sodium tungstate, ferrous sulfate and sodium molybdate, sodium tungstate and ferrous sulfate have a forward adjusting effect on increasing the yield of acetic acid, ethanol and butanol in the target product, and sodium molybdate has a reverse adjusting effect on the target product. By optimizing the proportion of trace elements in the culture medium, the clostridium metabolism efficiency is improved, synthesis of a target product is regulated and controlled, and the method is particularly suitable for industrial production of acetic acid, ethanol, butanol and the like.

A sunscreen formulation includes carbon quantum dots having reacted units of citric acid and thiamine and particles of a metal-organic framework including zinc and reacted units of terephthalic acid. The sunscreen formulation further comprises a liquid carrier and a stabilizer. The quantum dots are dispersed in the metal-organic framework. The particles of the metal-organic framework are dispersed in the liquid carrier.

The invention discloses a synthetic method of cocarboxylase tetrahydrate, which comprises the following steps: reacting thiamine phosphate with a condensing agent in an organic solvent to obtain an intermediate I; and reacting the intermediate I with phosphate to obtain cocarboxylase, and refining the cocarboxylase to obtain cocarboxylase tetrahydrate. According to the method disclosed by the invention, the byproduct thiamine monophosphate recovered in a traditional preparation process is used as a starting material to prepare the cocarboxylase tetrahydrate, so that the reaction selectivity is high, and the material utilization rate is increased; according to the method, the high-temperature reaction condition of the traditional process is avoided, the emission of hydrogen chloride gas is avoided, the use of organic solvents and highly toxic reagents is reduced, the pressure on environmental protection is relieved, and the reaction safety is improved.

The invention relates to the technical field of pet food, in particular to flavoring agent powder for pet dogs and a preparation method of the flavoring agent powder. Comprising the following raw materials: 40 parts of beef liver, 10 parts of hairtail, 7-40 parts of ricefield eel, 1 part of protease, 0.5-1 part of lipase, 0.5-1 part of flavor enzyme, 5-10 parts of saccharides, 10 parts of fish oil, 5-10 parts of maltodextrin, 0.5-1 part of sodium hydroxide, 5 parts of phosphoric acid, 3 parts of amino acid, 2 parts of thiamine, 1 part of yeast extract and 0.5-1 part of lactoferrin. The dog feed can increase the appetite of dogs from the sense of smell, maintain the health balance of intestinal flora of dogs and improve the micro-ecological environment of intestinal tracts.

The invention provides a thiamine-releasing bacillus miguli and application of the thiamine-releasing bacillus miguli. According to the invention, a strain of Aneurinibacillus migulanus X3-3 with resistance to a plurality of heavy metals is screened and separated from soil subjected to combined pollution of heavy metals, and is preserved in the China General Microbiological Culture Collection Center (CGMCC), and the registration number of the preservation center is CGMCC No.33798. The invention also discloses a method for preparing the Aneurinibacillus migulanus X3-3 with resistance to a plurality of heavy metals and application of the Aneurinibacillus migulanus X3-3. The strain can tolerate high-concentration heavy metal pollution, shows good heavy metal removal and solidification capabilities in water and soil, provides an efficient and environment-friendly microbial solution for remediation of a heavy metal combined pollution environment, and has a wide application prospect.

The present disclosure relates generally to methods of utilizing sonosensitizers in the presence of thiamine or a derivative thereof for the purpose of cross-linking animal tissue, producing singlet oxygen within or at the site of animal tissue, or treating a condition in a subject, wherein the condition is an aneurysm, cancer, and / or a scleral condition.

The invention discloses application of thiamine in preparation of a product for treating subclinical ketosis of dairy cows, and belongs to the field of biological medicines. Tests prove that compared with dairy cows suffering from subclinical ketosis (SCK), by adding thiamine, the content of beta-hydroxybutyric acid (BHBA), the number of bacteria in milk and the number of somatic cells can be remarkably reduced, and the milk yield, the milk fat content, the acetic acid content and the A / P ratio are remarkably increased; the microbial diversity of rumen and excrement of the dairy cow can be adjusted; a metabonomics result shows that metabolite up-regulated after the thiamine is added mainly focuses on pyruvic acid metabolism, glycolysis or gluconeogenesis, tyrosine metabolism, glycerophospholipid metabolism and biosynthetic pathways of phenylalanine, tyrosine and tryptophan. The conclusion is that when thiamine is added into the SCK dairy cow, synthesis and catabolism of BHBA of an organism can be effectively regulated and controlled by adjusting the content of succinyl-coenzyme A, then subclinical ketosis is relieved, rumen fermentation is promoted, and therefore the milk yield and the milk quality are improved.

The invention relates to a thiazole connection-based covalent organic framework nanofiltration membrane as well as a preparation method and application thereof. Amphiphilic thiamine-containing monomers and aldehyde monomers are used as interfacial polymerization monomers, and polymerization is performed on a liquid-liquid free interface to obtain the covalent organic framework nanofiltration membrane with thiazole bonds as connecting structure elements. The thiazole bond is used as a connecting element to improve the separation selectivity and acid resistance of the COF membrane, the molecule desalination selectivity of the thiazole-connected covalent organic framework nanofiltration membrane reaches 690, and the thiazole-connected covalent organic framework nanofiltration membrane can be stably stored for a long time in 12M HCl, can still stably run and be stored for a long time under the harsh conditions of mechanical stress, high temperature, strong corrosion and the like, and keeps excellent structural stability; the membrane can be used for membrane separation in a neutral environment or a strong acid environment.

The present application provides thiamine compounds shown in formula (I) and application thereof. The thiamine compounds of the present application can be used for preparing polyolefin antioxidants. The thiamine compounds of the present application introduce sulfide bonds in aryl secondary amine, so that the antioxidant contains naphthylamine groups of primary antioxidants and sulfide groups of auxiliary antioxidants, which not only can terminate free radicals by providing hydrogen protons, but also can react with hydroperoxides, so as to achieve the dual effects of primary and auxiliary antioxidants, and thus the antioxidant effect is significantly enhanced.

The present invention provides a thiamine sulfate crystal and an extraction method thereof, and relates to the technical field of thiamine sulfate purification, and the extraction method comprises the following steps: thiamine thiosulfate is oxidized by hydrogen peroxide to obtain an oxidation liquid, and the oxidation liquid is added into an organic solvent for crystallization and separation to obtain the thiamine sulfate crystal; the organic solvent comprises at least one of methanol, ethanol and acetone. According to the extraction method, the specific organic solvent is adopted to crystallize the thiamine sulfate, high-purity thiamine sulfate crystals can be extracted from the aqueous solution oxidized by thiamine thiosulfate, the purity can reach 99.70% or above, and the process is simple, efficient and suitable for industrial production.

A paediatric supplement or human milk fortifier composition comprising at least one nutrients selected in the list consisting of: ALA, DHA, EPA, 2FL, LNnT, vitamin A, thiamine, thiamine monophosphate, vitamin B2, vitamin B6, vitamin B9, calcium and phosphorus, GD3, GM3. Said paediatric supplement or human milk fortifier composition is tailored or adapted for a child born via C-section who is breast fed and / or to fortify the breast milk of a woman who has given birth via C-section. Said paediatric supplement or human milk fortifier composition is beneficial to provide adequate nutrition to a child born via C-section and promote associated health benefits.

The invention relates to a livestock breeding technology, and discloses a preparation method of a premix for enhancing laying hen production treatment, in the construction of a basic nutrition framework, the construction of a vitamin system is a core project, vitamin A is supplemented by adopting a palmitate form, the stability of the vitamin A in feed processing is ensured, the level of 8000-12000IU should be maintained in each kilogram of feed, and the content of the vitamin A in the feed processing is reduced. According to the fallopian tube mucous membrane composition, the addition amount of the vitamin D3 in the metabolic activity form of 25-hydroxyD3 needs to reach 2000-3000 IU / kg, the vitamin D3 and parathyroid hormone have a synergistic effect, the calcium and phosphorus deposition efficiency can be remarkably improved, particularly, the synergistic effect of B vitamins is worthy of attention, and thiamine (B1) and riboflavin (B2) are compatible according to the proportion of 1: 2. According to the preparation method of the premix for enhancing laying hen production treatment, the growth speed and the laying efficiency of chicken flocks are effectively improved, the eggshell quality is ensured, nutritional diseases such as chondropathy and egg reduction diseases are reduced, and the economic benefits of laying hen breeding are greatly improved.

The invention belongs to the technical field of pet food, and particularly relates to a protein cat food flavoring agent and a preparation method thereof.The preparation method of the protein cat food flavoring agent comprises the steps that meat extract, silkworm chrysalis homogenate, euphausia superba homogenate, pollen pini, ethyl maltol, a flavoring agent, trypsin, neutral protease and aminopeptidase are sequentially added for enzymolysis; an enzymolysis product is obtained; adding goat milk powder, carbohydrates, microencapsulated thiamine, pumpkin powder and amino acid into the reaction tank, uniformly mixing with the enzymolysis product, and carrying out Maillard reaction; after the Maillard reaction is finished, phosphoric acid and a thickening agent are added into the reaction tank, and a pasty flavoring agent is obtained; and carrying out spray drying on the pasty flavoring agent to obtain a powdery flavoring agent. The components jointly act on the cat food flavoring agent, so that the nutritional value of the flavoring agent is improved, the flavor level of the flavoring agent is richer and diversified, the flavoring agent can meet the favor of cats for flavor, and meanwhile, comprehensive nutritional support is provided.

The present invention includes at least a coloring material, water, thiamine, a thiamine derivative, or a salt thereof.

The application discloses a fermentation method for producing thiamine pyrophosphokinase and belongs to the technical field of bioengineering. The BL21 recombinant engineering bacteria containing pET28a-TPK, pET28a-ProS2-TPK or pET28a-SUMO-TPK are constructed, the seed liquid is prepared, the isopropyl-beta-D-thiogalactoside is used for inducing expression, the bacteria are collected, the cells are broken and the supernatant is collected to obtain the TPK crude enzyme liquid. In the fermentation, the LB / TB culture medium containing 50 μg / mL kanamycin or 100 μg / mL ampicillin is used. The SUMO label is introduced to guide the correct folding of the TPK, so that the soluble expression ratio of the TPK is more than 85%, the ratio is improved by 2 times compared with the common system, the inclusion body ratio is greatly reduced, the process is stable and has good repeatability, and an effective scheme is provided for the industrialized large-scale preparation of the TPK.

The invention relates to the technical field of powder conveying, and particularly discloses a thiamine nitrate finished product powder automatic conveying and quantitative discharging system which comprises a discharging pipe assembled below a powder hopper, and an elastic pressing piece, a pressing push ring and a control assembly are arranged on the discharging pipe; the multiple elastic pressing pieces are arranged in the circumferential direction of the discharging pipe, each elastic pressing piece comprises a connecting part fixedly connected with the discharging pipe and a movable part located below the connecting part, and the lower end of each movable part is obliquely arranged outwards in the radial direction; the pressing push ring sleeves the outer side of the connecting part in an up-down sliding manner; the control assembly is arranged at the discharging end of the discharging pipe and corresponds to the lower end of the movable part in position. The thiamine nitrate finished product powder automatic conveying and quantitative discharging system has the effects that dust diffusion can be effectively reduced, and meanwhile the powder bagging quality is improved.

A paediatric supplement or human milk fortifier composition comprising at least one nutrient selected in the list consisting of: ALA, DHA, EPA, 2′FL, LNnT, vitamin A, thiamine, thiamine monophosphate, vitamin B2, vitamin B6, vitamin B9, calcium and phosphorus, GD3, GM3. Said paediatric supplement or human milk fortifier composition is tailored or adapted for an infant born via C-section who is breast fed and / or to fortify the breast milk of a woman who has given birth via C-section. Said paediatric supplement or human milk fortifier composition is beneficial to prevent nutrition inadequacy an infant born via C-section and promote associated health benefits.

The present disclosure provides compositions and methods for providing a health benefit to a growing animal comprising administering a food composition to the animal, wherein the food composition includes a brain development blend. The brain development blend generally comprises DHA, EPA, taurine, choline, thiamine, riboflavin, pantothenic acid, niacin, pyridoxine, vitamin B12, and folic acid.

The invention discloses a preparation method of deep-color isopropyl ethyl thiamine ester, which comprises the following steps: taking 200g of isopropyl ethyl thiamine ester base material, adding 5g of 8% hydrogen peroxide (the effective HO accounts for 0.2%) under the stirring conditions of 35 DEG C and 250rpm, stirring for 10 minutes, adding 0.3-3.4 g of 70% monoethylamine, and reacting at constant temperature for 30 minutes to obtain a deep-color isopropyl ethyl thiamine ester product. According to the method, continuous controllable change of the color of the thiamine ester from light red yellow to dark red brown is realized by accurately controlling the ratio and the reaction condition at 35 DEG C, the deviation of the main peak of the product chromatography is less than or equal to 0.5%, layering and precipitation are avoided after standing in a dark place for 8 hours, the loss of main components is extremely low, the process stability is high, and the method is suitable for industrial production.

The invention discloses a nutritional additive for livestock, which is prepared from thiamine and nicotinamide in a mass ratio of (1-2): (1-2), and is a brand-new nutritional additive capable of effectively relieving the industrial problems of sheep breast immunity, oxidative damage, lactation performance reduction and the like caused by heat stress. Under the optimized additive amount, by applying the nutritional additive, the functions of mammary gland cells can be remarkably improved, and the milk yield and the content of milk components such as milk fat, milk protein and lactose can be increased; according to the nutritional additive, a safe and stable daily ration formula can be established, and the residual risk of traditional chemical drugs or excessive vitamins is avoided.

The present application provides a preparation method of thiamine compound shown in formula (I), wherein the method comprises using compound of formula (III) and R 15 X is used to prepare thiamine compound shown in formula (I),

The present invention relates to the use of a combination of vitamins, more specifically to the combined use of biotin and thiamine, for the treatment of Huntington's disease. More specifically, the present invention explains that treatment with a combination of biotin and thiamine can improve the neurological, neuroimaging and spectroscopic symptoms associated with Huntington's disease.

The invention discloses a formula of an organic mixed health-care beverage and a preparation method of the organic mixed health-care beverage. The raw materials comprise, by weight, 1-3 g of ginseng, 1-3 g of deer-horn glue, 2-5 g of folium cortex eucommiae, 2-5 g of gynostemma pentaphylla, 2-5 g of hawthorn, 2-5 g of ligusticum wallichii, 1-3 g of schisandra chinensis, 3-5 g of rhizoma polygonati, 2-5 g of radix ophiopogonis, 100-200 mg of algal oil, 200-300 mg of taurine, 150-200 mg of grape seed extract, 3-5 ml of perilla seed oil, 50-80 ml of yoghourt, 30-50 ml of walnut juice and 30-50 ml of peanut liquid. The selenium-enriched beverage is prepared from 30 to 50 milliliters of sweet almond liquid, 30 to 50 milliliters of black sesame liquid, 30 to 50 milliliters of mango juice, 50 to 100 milliliters of apple juice, 30 to 50 milliliters of tomato juice, 50 to 80 micrograms of selenium-enriched yeast, 25 to 50 milligrams of vitamin C, 125 to 25 milligrams of vitamin E, 0 to 15 milligrams of vitamin B1 {thiamine}, 15 milligrams of vitamin B2 {riboflavin}, 0 to 15 milligrams of vitamin B2 {pyridoxine}, 15 milligrams of vitamin B6 {pyridoxine}, 25 milligrams of vitamin B9 {folic acid}, 40 micrograms of vitamin B9 {folic acid}, and 0 to 75 milligrams of vitamin B12 {cobalamin}. After being taken by various people for a period of time, the health-care food is smooth and delicious in taste and free of adverse reaction through evaluation in multiple aspects, and the health-care effect and feeling state of the health-care food are better than those of the prior art. And the health-care tea is suitable for a wide range of people, is beneficial to market promotion, and enables more people to achieve the health-care effect of preventing diseases before diseases.

The present invention provides a stable solid preparation comprising a nicotinic acid and a vitamin B1. The present invention relates to a solid preparation characterized by comprising a nicotinic acid, a vitamin B1 and an alpha-modified starch.

The invention discloses an electroplated copper foil electroplating liquid leveling agent with a crystal face guiding effect, and the leveling agent is thiamine, N-ethyl ethylenediamine, glycine, N, N-bis (2-ethoxyl) glycine, hexamethylphosphoramide, theophylline, 3-cyanopyridine, 2-hydroxypyridine, beta-methylpyridine, 1-(2-mercaptobenzothiazole-3-yl) imidazole, 1, 2-diphenyl-1, 3-pentanediol, 1, 3-pentanediol, 1, 3-pentanediol, 1, 3-pentanediol, 1, 3-pentanediol, 1, 3-pentanediol, 1, 3-pentanediol, 1, 3-pentanediol, 1, 3-pentanediol, 1, 3-pentanediol, 1, 3-pentanediol and 1, 3-pentanediol. The catalyst is selected from one or more of 1, 3-bis (1-imidazolyl) propane, 2-amino-4-methylbenzothiazole and pyridinium propanesulfonate. The leveling agent disclosed by the invention can homogenize grain size distribution on the surface of the electroplated copper foil and reduce a wrinkle phenomenon caused by microstress in a post-treatment process of the copper foil; meanwhile, the material can be adsorbed on the surface of the copper foil, copper ion nucleation overpotential is increased, deposited grains are refined, and the tensile strength of the copper foil is improved.

The invention relates to an aneurinibacillus michaeli ZKSW002 as well as a fungicide and application thereof, and belongs to the technical field of microorganisms. The bacillus michaeli ZKSW002 is preserved in the China General Microbiological Culture Collection Center (CGMCC), the preservation number is CGMCC No.36075, the preservation date is September 25, 2025, and the address of the preservation institution is No.3, Yard 1, Beichen West Road, Chaoyang District, Beijing. The invention further provides application of the thiamine bacillus migulensis ZKSW002 in inhibition of harmful bacteria in soil, prevention and treatment of root-knot nematode and promotion of plant growth. The thiamine bacillus michaeli ZKSW002 disclosed by the invention not only can promote the growth of crops and realize weight loss and synergism, but also can control the occurrence of soil-borne fungal and bacterial diseases, and can inhibit the growth of root-knot nematode. Chemical pesticide application can be reduced, pesticide residues are reduced, and sustainable development of agricultural economy is promoted.

The invention relates to an elsholtzia and ginseng composite peptide special diet for improving cardiovascular and cerebrovascular diseases and microcirculation disturbance and a preparation method thereof. The special diet comprises the following components: 5-15% of small molecule peptide; 18-65% of a plant extract; 0.1 to 3 percent of gamma-aminobutyric acid; 0.01 to 1 percent of N-acetylneuraminic acid; 0.005% to 0.1% of thiamine; 0.001 to 0.05 percent of riboflavin; and the balance of auxiliary materials. Wherein the plant extract comprises at least one of elsholtzia, rhizoma zingiberis and ginseng. According to the scheme provided by the invention, the elasticity and permeability of blood capillaries can be improved, microcirculation can be improved, blood fat can be reduced, and cardiovascular and cerebrovascular diseases can be effectively prevented and relieved.

The invention provides stewed beef essence based on yeast cell walls and a preparation method of the stewed beef essence, and relates to the field of functional foods. The method comprises the following steps: by taking a by-product of yeast protein production, namely yeast cell walls, as a raw material, firstly, carrying out biological enzymolysis pretreatment to release flavor precursor substances in the yeast cell walls, and then, by taking yeast cell wall enzymatic hydrolysate as a main substrate, adding reducing sugar, cysteine, thiamine and other auxiliary materials, and carrying out enzymolysis to obtain the yeast cell wall flavor peptide. The stewed beef essence with strong meat flavor and mellow taste is prepared by a Maillard reaction damp-heat method. According to the invention, the yeast cell wall, which is a functional raw material rich in protein and polysaccharide, is creatively utilized to construct a novel meat flavor preparation system, so that not only is the dependence of the traditional meat flavor on animal-derived raw materials reduced, but also the production cost is remarkably reduced, and efficient conversion of biological resources is realized. The raw materials are natural in source, so that potential safety hazards possibly existing in pure chemical synthetic essence are avoided, and the development trend of label cleaning food is met.

The invention discloses a novel intestinal probiotic butyric acid monad and application thereof, the novel intestinal probiotic butyric acid monad is preserved in Guangdong Microbiological Culture Collection Center, and the preservation number is GDMCC No.67648. A mouse model proves that the butyric acid monad can promote synthesis of intestinal TMP (Trimethoprim) by remodeling intestinal steady state, and then the TMP is converted into thiamine. Through intestinal liver circulation, thiamine accumulates in the liver and is further converted into TPP. The process promotes the degradation of BCAs, further regulates the lipid metabolism of the liver, and obviously alleviates the progress of metabolic dysfunction related fatty liver diseases induced by high fat diet.