37 results about "Thiamine" patented technology

The present disclosure relates generally to methods of utilizing sonosensitizers in the presence of thiamine or a derivative thereof for the purpose of cross-linking animal tissue, producing singlet oxygen within or at the site of animal tissue, or treating a condition in a subject, wherein the condition is an aneurysm, cancer, and / or a scleral condition.

The invention discloses application of thiamine in preparation of a product for treating subclinical ketosis of dairy cows, and belongs to the field of biological medicines. Tests prove that compared with dairy cows suffering from subclinical ketosis (SCK), by adding thiamine, the content of beta-hydroxybutyric acid (BHBA), the number of bacteria in milk and the number of somatic cells can be remarkably reduced, and the milk yield, the milk fat content, the acetic acid content and the A / P ratio are remarkably increased; the microbial diversity of rumen and excrement of the dairy cow can be adjusted; a metabonomics result shows that metabolite up-regulated after the thiamine is added mainly focuses on pyruvic acid metabolism, glycolysis or gluconeogenesis, tyrosine metabolism, glycerophospholipid metabolism and biosynthetic pathways of phenylalanine, tyrosine and tryptophan. The conclusion is that when thiamine is added into the SCK dairy cow, synthesis and catabolism of BHBA of an organism can be effectively regulated and controlled by adjusting the content of succinyl-coenzyme A, then subclinical ketosis is relieved, rumen fermentation is promoted, and therefore the milk yield and the milk quality are improved.

The present application provides thiamine compounds shown in formula (I) and application thereof. The thiamine compounds of the present application can be used for preparing polyolefin antioxidants. The thiamine compounds of the present application introduce sulfide bonds in aryl secondary amine, so that the antioxidant contains naphthylamine groups of primary antioxidants and sulfide groups of auxiliary antioxidants, which not only can terminate free radicals by providing hydrogen protons, but also can react with hydroperoxides, so as to achieve the dual effects of primary and auxiliary antioxidants, and thus the antioxidant effect is significantly enhanced.

The present invention provides a thiamine sulfate crystal and an extraction method thereof, and relates to the technical field of thiamine sulfate purification, and the extraction method comprises the following steps: thiamine thiosulfate is oxidized by hydrogen peroxide to obtain an oxidation liquid, and the oxidation liquid is added into an organic solvent for crystallization and separation to obtain the thiamine sulfate crystal; the organic solvent comprises at least one of methanol, ethanol and acetone. According to the extraction method, the specific organic solvent is adopted to crystallize the thiamine sulfate, high-purity thiamine sulfate crystals can be extracted from the aqueous solution oxidized by thiamine thiosulfate, the purity can reach 99.70% or above, and the process is simple, efficient and suitable for industrial production.

The present invention includes at least a coloring material, water, thiamine, a thiamine derivative, or a salt thereof.

The application discloses a fermentation method for producing thiamine pyrophosphokinase and belongs to the technical field of bioengineering. The BL21 recombinant engineering bacteria containing pET28a-TPK, pET28a-ProS2-TPK or pET28a-SUMO-TPK are constructed, the seed liquid is prepared, the isopropyl-beta-D-thiogalactoside is used for inducing expression, the bacteria are collected, the cells are broken and the supernatant is collected to obtain the TPK crude enzyme liquid. In the fermentation, the LB / TB culture medium containing 50 μg / mL kanamycin or 100 μg / mL ampicillin is used. The SUMO label is introduced to guide the correct folding of the TPK, so that the soluble expression ratio of the TPK is more than 85%, the ratio is improved by 2 times compared with the common system, the inclusion body ratio is greatly reduced, the process is stable and has good repeatability, and an effective scheme is provided for the industrialized large-scale preparation of the TPK.

The invention relates to the technical field of powder conveying, and particularly discloses a thiamine nitrate finished product powder automatic conveying and quantitative discharging system which comprises a discharging pipe assembled below a powder hopper, and an elastic pressing piece, a pressing push ring and a control assembly are arranged on the discharging pipe; the multiple elastic pressing pieces are arranged in the circumferential direction of the discharging pipe, each elastic pressing piece comprises a connecting part fixedly connected with the discharging pipe and a movable part located below the connecting part, and the lower end of each movable part is obliquely arranged outwards in the radial direction; the pressing push ring sleeves the outer side of the connecting part in an up-down sliding manner; the control assembly is arranged at the discharging end of the discharging pipe and corresponds to the lower end of the movable part in position. The thiamine nitrate finished product powder automatic conveying and quantitative discharging system has the effects that dust diffusion can be effectively reduced, and meanwhile the powder bagging quality is improved.

The present disclosure provides compositions and methods for providing a health benefit to a growing animal comprising administering a food composition to the animal, wherein the food composition includes a brain development blend. The brain development blend generally comprises DHA, EPA, taurine, choline, thiamine, riboflavin, pantothenic acid, niacin, pyridoxine, vitamin B12, and folic acid.

The invention discloses a preparation method of deep-color isopropyl ethyl thiamine ester, which comprises the following steps: taking 200g of isopropyl ethyl thiamine ester base material, adding 5g of 8% hydrogen peroxide (the effective HO accounts for 0.2%) under the stirring conditions of 35 DEG C and 250rpm, stirring for 10 minutes, adding 0.3-3.4 g of 70% monoethylamine, and reacting at constant temperature for 30 minutes to obtain a deep-color isopropyl ethyl thiamine ester product. According to the method, continuous controllable change of the color of the thiamine ester from light red yellow to dark red brown is realized by accurately controlling the ratio and the reaction condition at 35 DEG C, the deviation of the main peak of the product chromatography is less than or equal to 0.5%, layering and precipitation are avoided after standing in a dark place for 8 hours, the loss of main components is extremely low, the process stability is high, and the method is suitable for industrial production.

The present application provides a preparation method of thiamine compound shown in formula (I), wherein the method comprises using compound of formula (III) and R 15 X is used to prepare thiamine compound shown in formula (I),

The present invention relates to the use of a combination of vitamins, more specifically to the combined use of biotin and thiamine, for the treatment of Huntington's disease. More specifically, the present invention explains that treatment with a combination of biotin and thiamine can improve the neurological, neuroimaging and spectroscopic symptoms associated with Huntington's disease.

The invention discloses a formula of an organic mixed health-care beverage and a preparation method of the organic mixed health-care beverage. The raw materials comprise, by weight, 1-3 g of ginseng, 1-3 g of deer-horn glue, 2-5 g of folium cortex eucommiae, 2-5 g of gynostemma pentaphylla, 2-5 g of hawthorn, 2-5 g of ligusticum wallichii, 1-3 g of schisandra chinensis, 3-5 g of rhizoma polygonati, 2-5 g of radix ophiopogonis, 100-200 mg of algal oil, 200-300 mg of taurine, 150-200 mg of grape seed extract, 3-5 ml of perilla seed oil, 50-80 ml of yoghourt, 30-50 ml of walnut juice and 30-50 ml of peanut liquid. The selenium-enriched beverage is prepared from 30 to 50 milliliters of sweet almond liquid, 30 to 50 milliliters of black sesame liquid, 30 to 50 milliliters of mango juice, 50 to 100 milliliters of apple juice, 30 to 50 milliliters of tomato juice, 50 to 80 micrograms of selenium-enriched yeast, 25 to 50 milligrams of vitamin C, 125 to 25 milligrams of vitamin E, 0 to 15 milligrams of vitamin B1 {thiamine}, 15 milligrams of vitamin B2 {riboflavin}, 0 to 15 milligrams of vitamin B2 {pyridoxine}, 15 milligrams of vitamin B6 {pyridoxine}, 25 milligrams of vitamin B9 {folic acid}, 40 micrograms of vitamin B9 {folic acid}, and 0 to 75 milligrams of vitamin B12 {cobalamin}. After being taken by various people for a period of time, the health-care food is smooth and delicious in taste and free of adverse reaction through evaluation in multiple aspects, and the health-care effect and feeling state of the health-care food are better than those of the prior art. And the health-care tea is suitable for a wide range of people, is beneficial to market promotion, and enables more people to achieve the health-care effect of preventing diseases before diseases.

The invention relates to an elsholtzia and ginseng composite peptide special diet for improving cardiovascular and cerebrovascular diseases and microcirculation disturbance and a preparation method thereof. The special diet comprises the following components: 5-15% of small molecule peptide; 18-65% of a plant extract; 0.1 to 3 percent of gamma-aminobutyric acid; 0.01 to 1 percent of N-acetylneuraminic acid; 0.005% to 0.1% of thiamine; 0.001 to 0.05 percent of riboflavin; and the balance of auxiliary materials. Wherein the plant extract comprises at least one of elsholtzia, rhizoma zingiberis and ginseng. According to the scheme provided by the invention, the elasticity and permeability of blood capillaries can be improved, microcirculation can be improved, blood fat can be reduced, and cardiovascular and cerebrovascular diseases can be effectively prevented and relieved.

The invention discloses a novel intestinal probiotic butyric acid monad and application thereof, the novel intestinal probiotic butyric acid monad is preserved in Guangdong Microbiological Culture Collection Center, and the preservation number is GDMCC No.67648. A mouse model proves that the butyric acid monad can promote synthesis of intestinal TMP (Trimethoprim) by remodeling intestinal steady state, and then the TMP is converted into thiamine. Through intestinal liver circulation, thiamine accumulates in the liver and is further converted into TPP. The process promotes the degradation of BCAs, further regulates the lipid metabolism of the liver, and obviously alleviates the progress of metabolic dysfunction related fatty liver diseases induced by high fat diet.

To provide an aqueous ink composition capable of maintaining stable quality over a long period of time.SOLUTION: The ink composition contains at least a coloring material, water, and thiamine, a thiamine derivative or a salt thereof.SELECTED DRAWING: None

A topical composition comprising a nanonised L-glutathione and cyclodextrin complex, together with ascorbic acid in a weight ratio of glutathione to ascorbic acid from 7:1 to 15:1 and from 1:1 to 1:15 and a further compound comprising dexpanthenol, thiamine, benzalkonium chloride, sodium hyaluronate or acetyl-L-cysteine, which composition is topically administered for treating the symptoms of viral infection including COVID-19 and influenza, and for treating herpes simplex, herpes zoster, post herpetic neuralgia, genital herpes, alcohol detoxification, high triglycerides, age or liver spots and lupus.

Provided is use of thiamine pyrophosphokinase TPK as a target in the treatment of Alzheimer's disease; and AD symptoms due to the inhibited TPK can be prevented by promoting the kinase activity and / or expression level of TPK protein in brain with TPK as a target.

The application provides a full-synthetic culture medium for 2-keto-gluconic acid producing bacteria proliferation and application thereof, and belongs to the technical field of microorganisms. The full-synthetic culture medium for 2-keto-gluconic acid producing bacteria proliferation culture comprises 10.0-40.0 g / L of glucose, 0.5-4.0 g / L of urea, 5.0-30.0 mg / L of thiamine, 0.5-3.0 mg / L of biotin, 1.0-4.0 g / L of NaH2PO4, 0.7-2.1 g / L of KH2PO4, 0.1-0.3 g / L of MgSO4·7H2O and 0.0-5.0 g of CaCO3. The full-synthetic culture medium or semi-synthetic culture medium is subjected to proliferation culture, and it is shown that the full-synthetic culture medium can completely replace the semi-synthetic culture medium, guarantees the repeatability of culture results, and further fermentation production of the bacteria strains subjected to the proliferation culture will not affect the stability of the fermentation production of the bacteria strains.

The invention provides a method of promoting weight management in a mammal comprising administering to the mammal a composition comprising at least one weight loss agent and at least one mitochondrial enhancer. The weight loss agent can be selected from the group consisting of psyllium, guar gum, capsaicin, chitosan, caffeine, gamboge, mume, capsaicin, yohimbine, butterfly pea, glucomannan, African mango, guarana, pyruvate, carnitine, beta-glucan, fucoxanthin, raspberry ketone, white kidney bean, kola nut, chromium, ginseng, psyllium, St. John's wort, dandelion, hydroxycitric acid, conjugated linoleic acid, green tea, black tea, coffee bean extract, forskolin, and bitter orange. The mitochondrial enhancer can be selected from the group consisting of beetroot extract, nitrate, idebenone, nicotinamide riboside, elamipretide, vitamin C, vitamin D, vitamin E, thiamine, riboflavin, magnesium, calcium, phosphate, phospholipid, creatine, pyruvate, coenzyme Q10, NADH, niacin, L-carnitine, dichloroacetate, curcumin, schisandrin, and resveratrol. Compositions for weight management are also provided.

The present invention relates to over the counter (OTC) film coated tablet compositions comprising one or more types of vitamins. Specifically, the invention focuses on formulations that include B vitamins, such as thiamine (B1), riboflavin (B2), nicotinamide (B3), pantothenic 5 acid (B5), pyridoxine (B6), biotin (B7), folic acid (B9), and cobalamin (B12). These vitamin- enriched tablets are intended for dietary supplementation to support various bodily functions, including energy metabolism, nervous system health, and the maintenance of healthy skin, hair, and eyes.

The invention relates to a method for increasing crop yield, and belongs to the field of agricultural science. The invention discloses a method for improving crop yield by spraying thiamine pyrophosphoric acid.

FIELD: biotechnology.SUBSTANCE: modified composition of a nutrient medium for inducing the formation of soybean regenerated plants in vitro, including ammonium nitrate (NH4NO3) – 1650 mg / l; potassium nitrate (KNO3) – 1900 mg / l; calcium chloride dihydrate (CaCl2×2H2O) – 440 mg / l; magnesium sulfate (MgSO4×7H2O) – 370 mg / l; potassium phosphate (KH2PO4) – 170 mg / l; disodium salt of ethylenediaminetetraacetic acid (Na2 EDTA) – 37.3 mg / l; ferrous sulfate (FeSO4×7H2O) – 27.95 mg / l; boric acid (H3VO3) – 6.2 mg / l; manganese sulfate (MnSO4×4H2O) – 22.3 mg / l; zinc sulfate (ZnSO4×H2O) – 8.6 mg / l; sodium molybdate (Na2MoO4×2H2O) – 0.25 mg / l; copper sulfate (CuSO4×5H2O) – 0.025 mg / l; thionyl chloride (CoCl2×H2O) – 0.025 mg / l; agar-agar – 7000 mg / l, according to the invention the following components are additionally introduced: glycine – 1.0 mg / l; mesoinositol – 120 mg / l; ascorbic acid – 3.0 mg / l; nicotinic acid – 1.0 mg / l; pyridoxine-HCl – 1.5 mg / l; thiamine-HCl – 1.0 mg / l; biotin – 0.03 mg / l; sucrose – 25000 mg / l; 6-BAP – 1.0 mg / l; indole-butyric acid (IBA) – 1.5 mg / l; starch – 9000 mg / l; activated carbon – 3.0 mg / l; water is the rest.EFFECT: expanding the range of nutrient medium compositions for inducing the formation of soybean regenerated plants in vitro.1 cl, 3 tbl

The invention discloses a compound bag for improving wooden meat of broiler chickens as well as a preparation method and application of the compound bag, and belongs to the field of animal feed additives. The compound bag is prepared from the following components in parts by mass: 100 to 150 parts of a humic acid copper chelate, 200 to 300 parts of a humic acid iron chelate, 200 to 300 parts of a humic acid manganese chelate, 150 to 200 parts of a humic acid zinc chelate, 50 to 100 parts of a humic acid cobalt chelate, 50 to 100 parts of a humic acid selenium chelate, 1 to 2 parts of vitamin E, 5 to 10 parts of vitamin C, 1 to 2 parts of nicotinamide, 1 to 2 parts of riboflavin, 1 to 2 parts of thiamine and 100 to 150 parts of a carrier. The prepared compound bag has the effects of humic acid and trace elements, and the humic acid can activate feed absorption, resist bacteria and diminish inflammation, astringe and stop diarrhea, treat nutritional diarrhea and protect intestinal health; trace elements and vitamins can meet the growth requirements of the broiler chickens, resist oxidative stress and improve the immunity; humic acid chelation can change the trace element absorption form and improve the trace element utilization rate. And the occurrence rate of the wooden meat of the broiler chicken is controlled below 2%.

The invention relates to the technical field of purification of intermediates in vitamin B1 production, in particular to a 2-methyl-4-amino-5-(thioformylthio) pyrimidine sodium salt crystallization process which comprises the following steps: mixing an aminopyrimidine aqueous solution with carbon disulfide, starting stirring and controlling the system temperature to be 28 DEG C; a sodium hydroxide solution with the mass fraction of 30% is dropwise added at the speed of 1.5 g / min, the pH value of the system is maintained to be 10.2 in the dropwise adding process, and heat preservation reaction is conducted for 1.5 h after dropwise adding is completed; by constructing a synergistic system of solvent selection, temperature control and reaction conditions, an impurity transfer path is effectively cut off, the extraction yield and purity of an intermediate are greatly improved, meanwhile, the content of key impurities is remarkably reduced, a guarantee is provided for high-quality production of downstream thiamine thiosulfate and thiamine nitrate, and compared with a traditional process, the method has the advantages that the cost is reduced, and the production efficiency is improved. And the product quality stability is greatly improved.

The present disclosure relates to a genetically modified host cell having improved production of thiamine, wherein the host cell expresses one or more heterologous ThiO enzymes converting glycine into dehydroglycine (DHG) in the host cell and / or one or more heterologous ThiI enzymes catalyzing the transfer of sulfur from IscS to the sulfur carrier protein ThiS in the host cell, whereby the production of the thiamine in the genetically modified host cell is improved compared to an unmodified parent host cell.

The invention relates to the technical field of phagostimulants, in particular to a natural plant protein biotransformation all-element liquid phagostimulant and a preparation method thereof, and the natural plant protein biotransformation all-element liquid phagostimulant comprises the following raw materials in parts by weight: 80-100 parts of a base material, 5-10 parts of maltodextrin, 0.5-1 part of xanthan gum, 0.2-0.4 part of sodium pyrophosphate, 2-5 parts of phosphoric acid, 0.05-0.15 part of potassium sorbate and 0.1-0.2 part of a rosemary extract. In the invention, the flavor raw material prepared by a step-by-step enzymolysis and fermentation process effectively overcomes the defect of insufficient vegetable protein flavor precursors, and in the Maillard reaction stage, by controlling the proportion and reaction conditions of the raw materials such as glucose, xylose, L-cysteine hydrochloride, thiamine and the like, the flavor of the vegetable protein is enriched. Key flavor substances such as nut flavor, baking flavor and sulfur-containing compounds (meat flavor) are efficiently generated, so that the final product presents a rich-level food calling flavor, and the attraction to pets is remarkably improved.

The present application relates to a device for cultivating Lactarius deliciosus by using the bark of pine tree and its using method, belonging to the field of edible mushroom cultivation. The present application solves the problem that Lactarius deliciosus is rarely grown on the bark of pine tree under natural conditions due to lack of spore source, moisture environment, water source and ventilation condition. The device comprises a water bucket (1), a spore cloth (7), a water-absorbing cloth (11) and a water-repellent cloth (14). The water bucket (1) provides water source, the spore cloth (7) is inoculated with Lactarius deliciosus spores, the water-absorbing cloth (11) supplies water source and maintains humidity, and the water-repellent cloth (14) blocks wind and reduces water evaporation. The using method is as follows: preparing LBLC culture medium, i.e. 20 g of potato, 2 g of glucose, 1 g of KHPO4, 1 g of KH2PO4, 1 g of thiamine and 1000 ml of water; winding the spore cloth (7), the water-absorbing cloth (11) and the water-repellent cloth (14); and binding the water bucket (1). The present application is used for cultivating Lactarius deliciosus on the bark of pine tree.

The invention provides a preparation method of a compound flavor flavoring agent, which specifically comprises the following steps: adding a proper amount of compound protease, which is prepared by compounding flavourzyme, peptidase and lipase, into fish soluble pulp, carrying out enzymolysis at 45-60 DEG C for 2-5 hours to obtain an enzymolysis product, preparing yeast powder into a suspension according to a ratio of 1kg: (4-6) L of water, and carrying out freeze-drying to obtain the compound flavor flavoring agent. Performing wall breaking on yeast to obtain wall-broken turbid liquid; mixing the enzymolysis product, the wall-broken turbid liquid and glucose to obtain a pasty or pasty reaction system, adding 0.1-0.5% of thiamine, 0.1-0.3% of L-cysteine hydrochloride and 0.5-2.0% of ascorbic acid (VC) into the reaction system according to a mass ratio, adding Mn < 2 + > with the concentration of 0.5-5.5 ppm into the reaction system, adjusting the pH value of the reaction system to 7.5-8.5, heating to 85-95 DEG C, keeping the temperature for 20-40 minutes, then heating the reaction system to 100-110 DEG C, keeping the temperature for 20-40 minutes, and cooling to room temperature to obtain a finished product. And cooling the reaction system to be less than or equal to 40 DEG C after keeping the temperature for 40-70 minutes, and cooling to 40 DEG C. In the preparation process, the reaction system is stirred at a low speed of 200-500 rpm, so that the material uniformity and temperature uniformity of the reaction system are improved.