97 results about "Propionitrile" patented technology

The invention discloses a low-concentration ether electrolyte adaptive to a high-voltage high-nickel ternary lithium ion battery, a preparation method of the low-concentration ether electrolyte and the lithium ion battery, and relates to the technical field of batteries. The ether electrolyte comprises a solvent and a solute; the solvent comprises an ether solvent, and is specifically at least one of 4-cyano tetrahydropyran, 2-(tetrahydro-2H-pyran-4-yl) acetonitrile, 2-methoxyacetonitrile, 2-ethyoxyl acetonitrile, 3-methoxypropionitrile, 3-ethyoxyl propionitrile, 3-butoxyl propionitrile, ethylene glycol bis (propionitrile) ether and 3-{2-[2-(2-cyano ethyoxyl) ethyoxyl] ethyoxyl} propionitrile. The ether solvent contains cyano groups, the strong electronegativity of the cyano groups enables the cyano groups to be coordinated with transition metal ions in the ternary material, and the cyano groups are preferentially adsorbed at the interface of the positive electrode material, so that the arrangement of solvent molecules at the interface has directivity, the proportion of ether oxygen bonds and carbon hydrogen atoms in double electric layers is reduced, and the performance of the positive electrode material is improved. And the sites which are easy to generate dehydrogenation reaction in the molecules are far away from the high-voltage positive electrode interface which is easy to generate oxidation reaction.

The invention provides a preparation method of hexafluoroisobutene, which comprises the following steps: firstly, reacting hexafluoroisopropanol with p-toluenesulfonyl chloride to generate an organic phase, then reacting with a cyano source to obtain 3, 3, 3-trifluoro-2-(trifluoromethyl) propionitrile, then reacting with an acid solution and a reducing agent in sequence to obtain hexafluoroisobutanol, and finally reacting with an acid solution and a reducing agent to obtain the hexafluoroisobutanol. And finally, carrying out alkali dehydration to generate hexafluoroisobutene. The preparation method provided by the invention is simple in process route and mild in reaction condition, the solvent used in the preparation process can be recycled, the pollution in the preparation process is reduced, and the preparation method is less in three wastes, environment-friendly and suitable for large-scale production.

The present application relates to the field of frother, in particular to a kind of copper flotation collector frother and preparation method thereof, by weight parts, including the following raw materials: N,N-dibutyl dithiocarbamic acid propyl cyanurate 100-120 parts, O-butyl-N-isobutyl thiopropyl carbamate 12-18 parts, xanthate 12-18 parts, phosphate ester polypropylene glycol ether 15-20 parts, modified betaine 5-8 parts, alcohol ether 3-5 parts, slime inhibitor 1-3 parts, alcohol ether carboxylate 2-5 parts, sorbitan monooleate 0.8-1.2 parts. Through the synergies of each raw material, the collector capacity, selectivity in copper flotation process can be effectively improved, and the reagent stability is good.

The application belongs to the field of chemical industry, and particularly relates to a preparation method of N,N,N',N'-tetramethyl diacrylamine, which comprises the following steps: hydrogenation reaction is carried out by introducing hydrogen into an amine group propyl cyanide compound, a dimethylamine aqueous solution and a catalyst; under the protection of inert gas, solid-liquid separation (filtration) is carried out on the obtained hydrogenated material, so that a filtrate and a filter cake are obtained; and the filtrate is subjected to rectification, so that N,N,N',N'-tetramethyl diacrylamine (2(DMAP)A) is obtained. The application has the advantages of simple process, mild conditions, green environmental protection, high product yield and facilitation of industrial production.

The invention discloses a tetrazine probe synthon and a preparation method and application thereof.The preparation method comprises the following steps that under the inert atmosphere, diethyl cyanomethylphosphonate, 3-hydroxypropionitrile, 3-mercaptopropionic acid and hydrazine hydrate are mixed and then react at the room temperature, a sodium nitrite solution is added after the reaction is finished, then acid is continuously added till the reaction system reaches acidity, and a tetrazine probe synthon product is obtained; continuously reacting to obtain an intermediate; and dissolving the intermediate in a solvent in an inert atmosphere, adding triethylamine, slowly adding methanesulfonyl chloride, and reacting at room temperature to obtain the tetrazine probe synthon shown in the formula I. The invention further discloses a preparation method of the tetrazine probe synthon. The tetrazine probe synthon provided by the invention can perform series Heck reaction and HWE reaction, so that controllable combination of functional groups on two sides of a tetrazine coupling probe is realized under mild reaction conditions, and the functional groups on two sides are designed according to actual requirements to regulate and control photophysical properties of the probe. A brand new way is provided for developing a high-performance biological orthogonal fluorescent probe.

The present disclosure is directed to polymorph Form 1 of 1H-pyrazole-1-propanenitrile, β-(cyclopentyl-2,2,3,3,4,4,5,5-d8)-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-, (βR)-, phosphate (1:1) (deuruxolitinib phosphate). Also disclosed are methods of treatment using polymorph Form 1 of deuruxolitinib phosphate and methods of making polymorph Form 1 of deuruxolitinib phosphate.

The invention discloses a preparation method of a cyanoborate lithium salt derivative, which comprises the following steps: 1, mixing an alcohol compound, a lithium source compound, a boron source compound and trimethylsilyl cyanide in a polar organic solvent, and filtering after complete reaction to obtain a cyanoborate crude product filtrate; the alcohol compound is selected from one of 2, 2, 2-trifluoroethanol, 2, 2-difluoroethanol, 2-fluoroethanol, 3-hydroxypropionitrile, allyl alcohol and propargyl alcohol; the lithium source compound is selected from one of lithium carbonate and lithium hydroxide; the boron source compound is selected from one of boric acid, diboron trioxide and boron tribromide; the reaction temperature is controlled to be 0-120 DEG C; and 2, adding an inert organic solvent into the cyanoborate crude product filtrate for crystallization, and performing vacuum drying to obtain a finished product of the cyanoborate lithium salt. The method has the advantages of high yield and purity, simple process, convenience in operation and low cost, and is extremely suitable for industrial production.

The present application relates to the field of chemical synthesis, in particular to a synthesis method of N-oxobutane acetamide and derivatives thereof.The synthesis method comprises the following steps: reacting a phenone compound with a nitrile compound, an acid and a reaction solvent to obtain the N-oxobutane acetamide and derivatives thereof; the phenone compound is p-bromophenone, p-fluorophenone, p-chlorophenone, p-iodophenone, p-cyanophenone, 3,4-dimethylphenone or 2-naphthaldehyde; the nitrile compound is acetonitrile, 3-chloropropionitrile, dichloroacetonitrile or deuterated acetonitrile; the acid is CF3SO3H or BF3; and the reaction solvent is acetonitrile or dichloroethane.The present application directly constructs the N-oxobutane acetamide and derivatives thereof in one step with the nitrile compound as the only nitrogen source, and has the advantages of cheap and easily available raw materials, mild conditions, high yield and easy scale-up production.

The application discloses a method for synthesizing 3-hydroxypropionitrile with high selectivity, and belongs to the technical field of organic synthesis. In the presence of a hydrophobic solvent and an alkaline catalyst, acrylonitrile and water are reacted to generate 3-hydroxypropionitrile. In the reaction system, the hydrophobic solvent and water constitute a two-phase reaction system, acrylonitrile is dissolved in the hydrophobic solvent, and the generated 3-hydroxypropionitrile is dissolved in water. The application introduces the hydrophobic solvent into the reaction system, increases the protection of the product 3-hydroxypropionitrile, reduces the further contact of the product 3-hydroxypropionitrile with acrylonitrile to generate di(cyanoethyl) ether, improves the selectivity of the reaction, and further improves the yield of 3-hydroxypropionitrile. The yield of 3-hydroxypropionitrile can reach about 72%, and the hydrophobic solvent and unreacted acrylonitrile can be recycled and used, thereby reducing the production cost. The application has the advantages of simple process, good reaction selectivity, high yield of the obtained product and low cost.

The present disclosure relates to a polymorph Form 1 of ([beta] R)-[beta]-(cyclopentyl-2, 2, 3, 3, 4, 4, 5, 5-d8)-4-(7H-pyrrolo [2, 3-d] pyrimidin-4-yl)-1H-pyrazol-1-propionitrile phosphate (1: 1) (deuterated ruxolitinib phosphate), in particular, to a polymorph Form 1 of ([beta] R)-[beta]-(cyclopentyl-2, 2, 3, 3, 4, 4, 5, 5-d8)-4-(7H-pyrrolo [2, 3-d] pyrimidin-4-yl)-1H-pyrazol-1-propionitrile phosphate (1: 1). Also disclosed are methods of treatment using the polymorph Form 1 of deuterated rusotinib phosphate and methods of producing the polymorph Form 1 of deuterated rusotinib phosphate.

The present invention provides a malonate salt form of (R)-3-(4-(7H-pyrrolo [2, 3-d] pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropionitrile and a crystal form thereof, the salt or crystal form can be used to modulate the activity of JAK kinase, and can be used to treat diseases associated with the activity or expression level of JAK kinase, such as JAK kinase. Including, for example, immune-related diseases, skin diseases, myeloproliferative disorders, cancer, and other diseases.

The invention relates to the technical field of organic synthesis, in particular to a synthesis method of N, N-dimethyl-1, 3-propane diamine. The synthesis method comprises the steps that N, N-dimethyl propionitrile and a modified Raney nickel-cobalt catalyst are mixed for a catalytic hydrogenation reaction, and the modified Raney nickel-cobalt catalyst is prepared from 0.1%-2.5% of chromium, 80%-85% of cobalt, 0.1%-2.5% of nickel and 7%-8% of aluminum. According to the synthesis method, caustic alkali or liquid ammonia does not need to be added, the raw material conversion rate is increased, the requirements of high-end products with ultra-purity (99.8%) and low moisture (less than or equal to 0.05%) can be met, and the impurity introduction risk is reduced.

The invention discloses a preparation method of tris (2-cyanoethyl) phosphate, which comprises the following steps of: 1, adding 3-hydroxypropionitrile, an organic alkali acid-binding agent and a reaction organic solvent which is one of dichloromethane and dichloroethane into a reaction container, and reacting at the temperature of between 20 and 30 DEG C for 1 to 3 hours; controlling the temperature not to exceed 20 DEG C, dropwise adding a mixture formed by phosphorus trichloride and a reaction organic solvent, after dropwise adding is completed, performing heating reflux reaction, and after the reaction is completed, performing suction filtration to remove generated organic alkali hydrochloride so as to obtain filtrate; and 2, controlling the temperature of the filtrate obtained in the step 1 at 30-40 DEG C, introducing oxygen for reaction until the reaction is finished, and removing the reaction organic solvent to obtain the final product tris (2-cyanoethyl) phosphate. The method has the advantages of simplicity in operation, mild and controllable reaction, high product purity and suitability for industrial popularization.

The present invention relates to the treatment of cutaneous lupus erythematosus. The problem to be solved by the invention is to provide a new pharmaceutical use of 3-[(3S,4R)-3-methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,6-diazaspiro[3,4]octan-1-yl]-3-oxopropanenitrile. A therapeutic or preventive agent cutaneous lupus erythematosus, containing 3-[(3S,4R)-3-methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,6-diazaspiro[3,4]octan-1-yl]-3-oxopropanenitrile as an active ingredient, and a pharmaceutical formulation thereof.

The invention discloses a novel ketorolac synthesis method, which takes 2-(1H-pyrrole-1-yl) propionitrile as a raw material, and ketorolac is obtained through the steps of cyclization reaction, benzoylation reaction, Vanderson reaction, hydrolysis reaction and the like.

The method comprises the following steps: by taking aminopropionitrile rectified high-boiling oil generated in a working section of preparing aminopropionitrile from acrylonitrile during production of VB1 as a raw material, carrying out reduced pressure rectification or in-situ catalytic cracking reduced pressure reaction rectification to obtain a distillate with the mass percentage content of dicyanoethylamine greater than 97% at the yield of 75% or more relative to the mass of the aminopropionitrile rectified high-boiling oil; dissolving the distillate by using an organic solvent, and carrying out catalytic chemical reduction or catalytic hydrogenation under an alkaline condition and in the presence of a catalyst to obtain a reduced material containing dipropylenetriamine, and centrifuging or filtering to separate out the catalyst and insoluble substances; the preparation method comprises the following steps of: adding an organic solvent into a reaction kettle, sequentially distilling to recover the organic solvent, rectifying under reduced pressure, collecting rectified fractions according to a relational expression t = 92.42 + 9.645 / (1.573-lgP) between a boiling point t (DEG C) of a material and a corresponding external pressure P (mmHg) to obtain dipropylenetriamine with the mass percentage content of more than 97%, reacting dipropylenetriamine with phthalic anhydride to generate a polyamide prepolymer, and reacting with epoxy chloropropane to obtain the dipropylenetriamine with the mass percentage content of more than 97%. The polyamide epoxy resin wet strength agent is obtained.

The application provides an electrolyte and a battery comprising the electrolyte, the electrolyte comprising an organic solvent, an electrolyte salt and a functional additive, wherein the functional additive comprises a first additive and a second additive, the first additive is selected from a sulfonyl fluoride compound, and the second additive is selected from 3,3',3'',3'''-(ethane-1,1,2,2-tetraalkyltetra(oxy))tetrapropionitrile. There is a synergistic effect between the first additive and the second additive in the electrolyte, and the two can jointly generate a stable CEI film on the surface of the positive active material in the charging and discharging process.

This invention discloses a metal- and amine-functionalized imidazole-based porous organic polymer (POPs-n@Ag2O) capable of catalyzing the in situ conversion of low-concentration CO2, as well as its preparation method and application. To prepare POPs-n@Ag2O, the active monomer, divinylbenzene (DVB), amino units, and 2,2'-azobis(2-methylpropionitrile) (AIBN) are first dissolved in dimethyl sulfoxide for polymerization. The reaction is heated to 100°C for 24 hours. POPs-n and Ag2O are then mixed in CH2Cl2 and stirred for 24 hours. The resulting precipitate is washed with ethyl acetate, H2O, and MeOH, and then vacuum-dried to obtain POPs-n@Ag2O. Using POP-6@Ag2O as a catalyst, the POPs-n@Ag2O can convert CO2 from actual coal-fired flue gas into oxazolidine-2,4-dione in situ, with a maximum yield of 92%. In addition, the structure-activity relationship of POP‑6@Ag2O was studied by correlating the BET specific surface area, average pore volume and nitrogen content with the CO2 absorption capacity and conversion efficiency, thereby clarifying the mechanism by which the structural characteristics of POP‑6@Ag2O affect the catalytic activity, providing an effective catalytic framework for in situ CO2 conversion under practical conditions.

The invention discloses a preparation method of a catalyst for propionitrile hydrogenation to prepare propylamine, which comprises the following steps: mixing and grinding ammonia borane and hexagonal boron nitride, carrying out temperature programming pyrolysis, washing and drying to obtain a mesoporous BN material; then hydrogen is introduced for gradient etching, and gradient nitrogen vacancies are constructed; adding the gradient nitrogen vacancy BN carrier into a nickel-iron precursor solution and a triethylamine-ethanol mixed solution, and carrying out solvothermal loading to complete in-situ reduction and loading; and finally, applying the prepared catalyst to the propionitrile hydrogenation to prepare the propylamine. The catalyst prepared by the method has the characteristics of large specific surface area (700-900 m < 2 > / g), concentrated pore size distribution (2-15 nm) and the like, and shows excellent catalytic performance in a propionitrile hydrogenation reaction, the propionitrile conversion rate is greater than or equal to 98%, the propylamine selectivity is greater than or equal to 98.7%, and the dipropylamine generation amount is 1t; 0.5%; compared with the prior art, the invention has the advantages of simple preparation process, low cost, high catalyst activity, good stability, mild reaction conditions, low energy consumption, strong safety and good industrial application prospect.

The application provides a synthesis method of 4-chloro-2-cyano-5-p-tolyl-1 H Imidazole, and belongs to the field of synthesis of medical intermediates. The method uses toluene and dichloropropionitrile as raw materials, and firstly obtains 1-p-tolyl-2,2-dichloro ethylimine through an addition reaction, then obtains 1-hydroxy-4-p-tolylimidazole-2-methyl aldoxime through a cyclization reaction under alkaline conditions, and then obtains the target product through chlorination and oxidation. Compared with the existing synthesis method, the application innovatively constructs the imidazole ring, generates a relatively stable intermediate containing aldoxime structure, and then generates a cyano group mildly and greenly. The design not only simplifies the reaction path, but also significantly reduces the safety risk in industrial production.

The application provides a supercapacitor electrolyte with low self-discharge, a preparation method and application thereof, raw materials of the supercapacitor electrolyte include organic solvents, ammonium salt and pyridine oxide; the organic solvents are one or more of acetonitrile, fluoroacetonitrile, propionitrile, butyronitrile and isobutyronitrile; the ammonium salt is tetraethylamine bistrifluoromethylsulfonylimide or tetraethylammonium bis(trifluoromethanesulfonyl)imide; and the pyridine oxide is pyridine-N-oxide, 4-methylpyridine oxide or 3-methylpyridine oxide. By selective use of specific additives and optimized configuration of electrolyte salt, the supercapacitor electrolyte of the application can effectively reduce the self-discharge rate of the supercapacitor and significantly improve the energy utilization efficiency of the capacitor.

The present disclosure relates to methods of treatment of asthma, COPD, Asthma-COPD Overlap Syndrome (ACOS), and chronic bronchitis, or a combination thereof, with formulations comprising (S)-3-(3-(1-methyl-2-oxo-5-(pyrazolo[1,5-a]pyridin-3-yl)-1,2-dihydro-3H-imidazo[4,5-b]pyridin-3-yl)piperidin-1-yl)-3-oxopropanenitrile.

The invention belongs to the field of fine chemical engineering, and provides a synthetic method of a cooling agent intermediate 2, 2-diisopropyl propionitrile. According to the preparation method, a design of combining a sea urchin-shaped silicon dioxide loaded phosphorus pentoxide solid dehydrating agent and an ethyl acetate n-heptane composite solvent system is adopted, the sea urchin-shaped dehydrating agent with high bulk density and low moisture is prepared by an isovolumetric impregnation precursor conversion method, and efficient conversion is realized in an azeotropic water-carrying or one-pot amidation dehydration process; the high-quality target nitrile product of which the chromatographic purity is not lower than 99.5%, the moisture is not higher than 300 ppm, the chromaticity is not higher than 10, the phosphorus residue is not higher than 10 ppm in terms of P, and the total halogen is not higher than 20 ppm in terms of Cl is realized by combining vacuum rectification with activated carbon adsorption refining; the problems of limited rheological heat transfer, contradiction between high-temperature conversion and low chromaticity and low oxidation and difficulty in simultaneous ultralow control of phosphorus and halogen residues caused by overhigh solid content in a traditional dehydration process are solved, and the method has wide application value suitable for industrial amplification.

The application relates to a non-aqueous calcium battery electrolyte and a non-aqueous calcium battery containing the electrolyte, and belongs to the technical field of batteries. The electrolyte comprises an electrolyte calcium salt, an amine organic solvent and a nitrile additive; wherein the concentration of the electrolyte calcium salt in the amine organic solvent is 0.05-5 mol / L, and the addition amount of the nitrile additive is 0.01-10 wt% of the total mass of the electrolyte calcium salt and the amine organic solvent. The nitrile additive is any one or a combination of 3,3-oxydipropionitrile, hexanetricarbonitrile, ethoxymethylenemalononitrile, adiponitrile, butanedinitrile, maleonitrile, 3-methoxypropionitrile, 4,4-dimethoxybutyronitrile and 1,2,3-tris(2-cyanoethyloxy)propane. Compared with the prior art, the non-aqueous calcium battery electrolyte of the application can construct an interface with stability and ionic conductivity when applied to a calcium battery negative electrode, so that the calcium battery exhibits excellent cycle performance and rate performance.

The invention discloses a production process of N, N-dimethyl propane diamine, which comprises the following steps: carrying out addition reaction on dimethylamine and acrylonitrile in the absence of a catalyst to obtain an intermediate dimethylaminopropionitrile and a small amount of addition byproducts; carrying out hydrogenation reaction on the intermediate under the conditions of a hydrogenation catalyst, an alkaline auxiliary agent and an alcohol solvent to produce a target product N, N-dimethyl propane diamine, a small amount of byproducts such as tetramethyl propane diamine (TMAPA) and propylamine, and reaction slurry containing the hydrogenation catalyst; reaction slurry enters a catalyst filter to be filtered; carrying out flash evaporation on the filtered reaction clear liquid in a hot high-pressure separation tank; further separating a liquid-phase reaction product in the light component removal tower; and further separating the mixture in a product refining tower to obtain a qualified product N, N-dimethyl propane diamine, and the like. According to the production process, the qualified product N, N-dimethyl propane diamine can be continuously produced, the purity of the product is 99.5% or above, and the yield is 95% or above.

A secondary battery and an electronic device. The secondary battery comprises an electrolyte and a separator. The electrolyte comprises a lithium salt additive and ethylene glycol bis(propionitrile) ether. Based on the total mass of the electrolyte, the mass percentage content of the lithium salt additive is A%, and the mass percentage content of the ethylene glycol bis(propionitrile) ether is B%, wherein 0.035≤A / B≤20. The lithium salt additive satisfies at least one of the following features: a. the lithium salt additive comprises lithium bis(fluorosulfonyl)imide, wherein 0.1≤A≤ 2.5; and b. the lithium salt additive comprises lithium tetrafluoroborate, wherein 0.1≤A≤ 2.5. The separator comprises a substrate layer, and the porosity of the substrate layer is P%, wherein 15≤P≤35. The electrolyte and the separator are adopted, and the values of A / B, A, and P are controlled to be within the above ranges, such that the secondary battery can have better low-temperature float charging performance, safety performance, and resistance to overcharging under high-temperature and high-voltage conditions.

The application discloses a method for efficiently preparing beta-amino propionic acid calcium from beta-amino propionitrile, and comprises the following steps: beta-amino propionitrile and a calcium salt solution are reacted in the presence of a catalyst and an additive, and microwave radiation is used to promote the reaction; after the reaction solution is filtered and deaminated, the solution is concentrated, cooled and alcohol crystallized to obtain beta-amino propionic acid calcium crystals which can be used for the production of calcium pantothenate; wherein the catalyst is a transition metal complex, and the additive is a phase transfer catalyst or a buffer metal salt. The application has the advantages of simple process, high yield and high reaction efficiency.

Title of the Invention: Novel process for the preparation of (R)-3-(4-(7H- pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile or a salt thereof The present invention relates to a novel process for the preparation of (R)-3-(4-(7H- pyrrolo[2,3­d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile or a salt thereof, which is referred to as Ruxolitinib and represented by the following structural formulae, Formula-1