60 results about "Propionitrile" patented technology

The present application relates to the field of frother, in particular to a kind of copper flotation collector frother and preparation method thereof, by weight parts, including the following raw materials: N,N-dibutyl dithiocarbamic acid propyl cyanurate 100-120 parts, O-butyl-N-isobutyl thiopropyl carbamate 12-18 parts, xanthate 12-18 parts, phosphate ester polypropylene glycol ether 15-20 parts, modified betaine 5-8 parts, alcohol ether 3-5 parts, slime inhibitor 1-3 parts, alcohol ether carboxylate 2-5 parts, sorbitan monooleate 0.8-1.2 parts. Through the synergies of each raw material, the collector capacity, selectivity in copper flotation process can be effectively improved, and the reagent stability is good.

The invention discloses a tetrazine probe synthon and a preparation method and application thereof.The preparation method comprises the following steps that under the inert atmosphere, diethyl cyanomethylphosphonate, 3-hydroxypropionitrile, 3-mercaptopropionic acid and hydrazine hydrate are mixed and then react at the room temperature, a sodium nitrite solution is added after the reaction is finished, then acid is continuously added till the reaction system reaches acidity, and a tetrazine probe synthon product is obtained; continuously reacting to obtain an intermediate; and dissolving the intermediate in a solvent in an inert atmosphere, adding triethylamine, slowly adding methanesulfonyl chloride, and reacting at room temperature to obtain the tetrazine probe synthon shown in the formula I. The invention further discloses a preparation method of the tetrazine probe synthon. The tetrazine probe synthon provided by the invention can perform series Heck reaction and HWE reaction, so that controllable combination of functional groups on two sides of a tetrazine coupling probe is realized under mild reaction conditions, and the functional groups on two sides are designed according to actual requirements to regulate and control photophysical properties of the probe. A brand new way is provided for developing a high-performance biological orthogonal fluorescent probe.

The invention relates to the technical field of organic synthesis, in particular to a synthesis method of N, N-dimethyl-1, 3-propane diamine. The synthesis method comprises the steps that N, N-dimethyl propionitrile and a modified Raney nickel-cobalt catalyst are mixed for a catalytic hydrogenation reaction, and the modified Raney nickel-cobalt catalyst is prepared from 0.1%-2.5% of chromium, 80%-85% of cobalt, 0.1%-2.5% of nickel and 7%-8% of aluminum. According to the synthesis method, caustic alkali or liquid ammonia does not need to be added, the raw material conversion rate is increased, the requirements of high-end products with ultra-purity (99.8%) and low moisture (less than or equal to 0.05%) can be met, and the impurity introduction risk is reduced.

The invention discloses a preparation method of tris (2-cyanoethyl) phosphate, which comprises the following steps of: 1, adding 3-hydroxypropionitrile, an organic alkali acid-binding agent and a reaction organic solvent which is one of dichloromethane and dichloroethane into a reaction container, and reacting at the temperature of between 20 and 30 DEG C for 1 to 3 hours; controlling the temperature not to exceed 20 DEG C, dropwise adding a mixture formed by phosphorus trichloride and a reaction organic solvent, after dropwise adding is completed, performing heating reflux reaction, and after the reaction is completed, performing suction filtration to remove generated organic alkali hydrochloride so as to obtain filtrate; and 2, controlling the temperature of the filtrate obtained in the step 1 at 30-40 DEG C, introducing oxygen for reaction until the reaction is finished, and removing the reaction organic solvent to obtain the final product tris (2-cyanoethyl) phosphate. The method has the advantages of simplicity in operation, mild and controllable reaction, high product purity and suitability for industrial popularization.

The present invention relates to the treatment of cutaneous lupus erythematosus. The problem to be solved by the invention is to provide a new pharmaceutical use of 3-[(3S,4R)-3-methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,6-diazaspiro[3,4]octan-1-yl]-3-oxopropanenitrile. A therapeutic or preventive agent cutaneous lupus erythematosus, containing 3-[(3S,4R)-3-methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,6-diazaspiro[3,4]octan-1-yl]-3-oxopropanenitrile as an active ingredient, and a pharmaceutical formulation thereof.

The method comprises the following steps: by taking aminopropionitrile rectified high-boiling oil generated in a working section of preparing aminopropionitrile from acrylonitrile during production of VB1 as a raw material, carrying out reduced pressure rectification or in-situ catalytic cracking reduced pressure reaction rectification to obtain a distillate with the mass percentage content of dicyanoethylamine greater than 97% at the yield of 75% or more relative to the mass of the aminopropionitrile rectified high-boiling oil; dissolving the distillate by using an organic solvent, and carrying out catalytic chemical reduction or catalytic hydrogenation under an alkaline condition and in the presence of a catalyst to obtain a reduced material containing dipropylenetriamine, and centrifuging or filtering to separate out the catalyst and insoluble substances; the preparation method comprises the following steps of: adding an organic solvent into a reaction kettle, sequentially distilling to recover the organic solvent, rectifying under reduced pressure, collecting rectified fractions according to a relational expression t = 92.42 + 9.645 / (1.573-lgP) between a boiling point t (DEG C) of a material and a corresponding external pressure P (mmHg) to obtain dipropylenetriamine with the mass percentage content of more than 97%, reacting dipropylenetriamine with phthalic anhydride to generate a polyamide prepolymer, and reacting with epoxy chloropropane to obtain the dipropylenetriamine with the mass percentage content of more than 97%. The polyamide epoxy resin wet strength agent is obtained.

The application provides a synthesis method of 4-chloro-2-cyano-5-p-tolyl-1 H Imidazole, and belongs to the field of synthesis of medical intermediates. The method uses toluene and dichloropropionitrile as raw materials, and firstly obtains 1-p-tolyl-2,2-dichloro ethylimine through an addition reaction, then obtains 1-hydroxy-4-p-tolylimidazole-2-methyl aldoxime through a cyclization reaction under alkaline conditions, and then obtains the target product through chlorination and oxidation. Compared with the existing synthesis method, the application innovatively constructs the imidazole ring, generates a relatively stable intermediate containing aldoxime structure, and then generates a cyano group mildly and greenly. The design not only simplifies the reaction path, but also significantly reduces the safety risk in industrial production.

The application provides a supercapacitor electrolyte with low self-discharge, a preparation method and application thereof, raw materials of the supercapacitor electrolyte include organic solvents, ammonium salt and pyridine oxide; the organic solvents are one or more of acetonitrile, fluoroacetonitrile, propionitrile, butyronitrile and isobutyronitrile; the ammonium salt is tetraethylamine bistrifluoromethylsulfonylimide or tetraethylammonium bis(trifluoromethanesulfonyl)imide; and the pyridine oxide is pyridine-N-oxide, 4-methylpyridine oxide or 3-methylpyridine oxide. By selective use of specific additives and optimized configuration of electrolyte salt, the supercapacitor electrolyte of the application can effectively reduce the self-discharge rate of the supercapacitor and significantly improve the energy utilization efficiency of the capacitor.

The present disclosure relates to methods of treatment of asthma, COPD, Asthma-COPD Overlap Syndrome (ACOS), and chronic bronchitis, or a combination thereof, with formulations comprising (S)-3-(3-(1-methyl-2-oxo-5-(pyrazolo[1,5-a]pyridin-3-yl)-1,2-dihydro-3H-imidazo[4,5-b]pyridin-3-yl)piperidin-1-yl)-3-oxopropanenitrile.

The invention belongs to the field of fine chemical engineering, and provides a synthetic method of a cooling agent intermediate 2, 2-diisopropyl propionitrile. According to the preparation method, a design of combining a sea urchin-shaped silicon dioxide loaded phosphorus pentoxide solid dehydrating agent and an ethyl acetate n-heptane composite solvent system is adopted, the sea urchin-shaped dehydrating agent with high bulk density and low moisture is prepared by an isovolumetric impregnation precursor conversion method, and efficient conversion is realized in an azeotropic water-carrying or one-pot amidation dehydration process; the high-quality target nitrile product of which the chromatographic purity is not lower than 99.5%, the moisture is not higher than 300 ppm, the chromaticity is not higher than 10, the phosphorus residue is not higher than 10 ppm in terms of P, and the total halogen is not higher than 20 ppm in terms of Cl is realized by combining vacuum rectification with activated carbon adsorption refining; the problems of limited rheological heat transfer, contradiction between high-temperature conversion and low chromaticity and low oxidation and difficulty in simultaneous ultralow control of phosphorus and halogen residues caused by overhigh solid content in a traditional dehydration process are solved, and the method has wide application value suitable for industrial amplification.

The application relates to a non-aqueous calcium battery electrolyte and a non-aqueous calcium battery containing the electrolyte, and belongs to the technical field of batteries. The electrolyte comprises an electrolyte calcium salt, an amine organic solvent and a nitrile additive; wherein the concentration of the electrolyte calcium salt in the amine organic solvent is 0.05-5 mol / L, and the addition amount of the nitrile additive is 0.01-10 wt% of the total mass of the electrolyte calcium salt and the amine organic solvent. The nitrile additive is any one or a combination of 3,3-oxydipropionitrile, hexanetricarbonitrile, ethoxymethylenemalononitrile, adiponitrile, butanedinitrile, maleonitrile, 3-methoxypropionitrile, 4,4-dimethoxybutyronitrile and 1,2,3-tris(2-cyanoethyloxy)propane. Compared with the prior art, the non-aqueous calcium battery electrolyte of the application can construct an interface with stability and ionic conductivity when applied to a calcium battery negative electrode, so that the calcium battery exhibits excellent cycle performance and rate performance.

The invention discloses a production process of N, N-dimethyl propane diamine, which comprises the following steps: carrying out addition reaction on dimethylamine and acrylonitrile in the absence of a catalyst to obtain an intermediate dimethylaminopropionitrile and a small amount of addition byproducts; carrying out hydrogenation reaction on the intermediate under the conditions of a hydrogenation catalyst, an alkaline auxiliary agent and an alcohol solvent to produce a target product N, N-dimethyl propane diamine, a small amount of byproducts such as tetramethyl propane diamine (TMAPA) and propylamine, and reaction slurry containing the hydrogenation catalyst; reaction slurry enters a catalyst filter to be filtered; carrying out flash evaporation on the filtered reaction clear liquid in a hot high-pressure separation tank; further separating a liquid-phase reaction product in the light component removal tower; and further separating the mixture in a product refining tower to obtain a qualified product N, N-dimethyl propane diamine, and the like. According to the production process, the qualified product N, N-dimethyl propane diamine can be continuously produced, the purity of the product is 99.5% or above, and the yield is 95% or above.

A secondary battery and an electronic device. The secondary battery comprises an electrolyte and a separator. The electrolyte comprises a lithium salt additive and ethylene glycol bis(propionitrile) ether. Based on the total mass of the electrolyte, the mass percentage content of the lithium salt additive is A%, and the mass percentage content of the ethylene glycol bis(propionitrile) ether is B%, wherein 0.035≤A / B≤20. The lithium salt additive satisfies at least one of the following features: a. the lithium salt additive comprises lithium bis(fluorosulfonyl)imide, wherein 0.1≤A≤ 2.5; and b. the lithium salt additive comprises lithium tetrafluoroborate, wherein 0.1≤A≤ 2.5. The separator comprises a substrate layer, and the porosity of the substrate layer is P%, wherein 15≤P≤35. The electrolyte and the separator are adopted, and the values of A / B, A, and P are controlled to be within the above ranges, such that the secondary battery can have better low-temperature float charging performance, safety performance, and resistance to overcharging under high-temperature and high-voltage conditions.

The application discloses a method for efficiently preparing beta-amino propionic acid calcium from beta-amino propionitrile, and comprises the following steps: beta-amino propionitrile and a calcium salt solution are reacted in the presence of a catalyst and an additive, and microwave radiation is used to promote the reaction; after the reaction solution is filtered and deaminated, the solution is concentrated, cooled and alcohol crystallized to obtain beta-amino propionic acid calcium crystals which can be used for the production of calcium pantothenate; wherein the catalyst is a transition metal complex, and the additive is a phase transfer catalyst or a buffer metal salt. The application has the advantages of simple process, high yield and high reaction efficiency.

Title of the Invention: Novel process for the preparation of (R)-3-(4-(7H- pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile or a salt thereof The present invention relates to a novel process for the preparation of (R)-3-(4-(7H- pyrrolo[2,3­d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile or a salt thereof, which is referred to as Ruxolitinib and represented by the following structural formulae, Formula-1

The invention provides a method for detecting the purity or content of 3-cyclopentyl-3-hydrazinopropionitrile or salt or hydrate thereof, and belongs to the field of analytical chemistry. The detection method comprises the step of detecting by adopting a gas chromatographic method, wherein the gas chromatographic method adopts a CAM gas chromatographic column or a DB-17 gas chromatographic column as a separation chromatographic column for separation. The detection method has the advantages of good separation degree, good peak pattern, simplicity in operation, simplicity, rapidness and the like.

The present disclosure relates to methods of treatment of asthma, COPD, Asthma-COPD Overlap Syndrome (ACOS), and chronic bronchitis, or a combination thereof, with formulations comprising (S)-3-(3-(1-methyl-2-oxo-5-(pyrazolo[1,5-a]pyridin-3-yl)-1,2-dihydro-3H-imidazo[4,5-b]pyridin-3-yl)piperidin-1-yl)-3-oxopropanenitrile.

Aminopropionitrile rectified high-boiling oil generated in an aminopropionitrile preparation section when acrylonitrile is used as a raw material to produce VB1 is subjected to reduced pressure rectification or in-situ catalytic cracking reduced pressure reaction rectification, so that dicyanoethylamine distillate with the mass percentage content of dicyanoethylamine greater than 97% is obtained at the yield of 75% or more relative to the mass of the aminopropionitrile rectified high-boiling oil. The method comprises the following steps: dissolving dicyanoethylamine distillate by using an organic solvent, and carrying out catalytic reduction on the dicyanoethylamine distillate by using one or a mixture consisting of more of NH2NH2, NHNH, NaBH4, KBH4 and NaBH3CN in proportion under an alkaline condition in the presence of a catalyst, so as to obtain a reduced material containing dipropylenetriamine. Centrifuging or filtering the obtained hydride material containing dipropylenetriamine to separate out the catalyst and insoluble substances, then distilling to recover the organic solvent, rectifying under reduced pressure, and collecting the rectified fraction according to the relational expression t = 92.42 + 9.645 / (1.573-lgP) between the boiling point t (DEG C) of the material and the corresponding external pressure P (mmHg), therefore, a dipropylenetriamine product with the mass percentage content of more than 97% is obtained.

The invention provides a high-yield synthesis method of trimethoprim, which comprises the following steps: (a) adding 3-methoxypropionitrile and 3, 4, 5-trimethoxybenzaldehyde into an organic alcohol alkali-organic alcohol solution, heating to 30-45 DEG C, and carrying out condensation reaction; (b) directly decompressing the condensation product obtained in the step (a) to remove most organic alcohol, then adding an alcohol ether solvent and guanidine nitrate, heating to 70-80 DEG C, and reacting until the reaction is finished; and cooling to 0-5 DEG C to obtain a trimethoprim crude product. The trimethoprim with high yield can be obtained only by using a one-pot method without treating an intermediate, so that the process is simple, and the working procedure and the working hour are saved; alcohol ether is used as a solvent in the ring closing step, so that the yield is further improved.

The application discloses a preparation method of S4-(2-cyanoethyl)-4-thiothymine deoxyriboside monomer, and 5'-O-DMT-uridine is used as a starting material. First, the starting material is reacted with a sulfonylation reagent to generate a sulfonylation reaction on a carbonyl group at a 4 position of the starting material to obtain compound II. Then, the compound II is reacted with 3-mercapto propionitrile to continuously generate a substitution reaction on the 4 position to obtain compound III. Finally, the compound III is reacted with a phosphorus reagent to obtain the S4-(2-cyanoethyl)-4-thiothymine deoxyriboside monomer. The method does not need to protect a 3'-hydroxyl group, has a shorter reaction route, milder reaction conditions, and high synthesis efficiency.

The invention discloses a low-temperature lithium-sulfur battery based on monatomic catalysis and organic sulfur electrolyte and a preparation method of the low-temperature lithium-sulfur battery. The low-temperature lithium-sulfur battery comprises a lithium negative electrode, a sulfur-carbon positive electrode, an organic sulfur added electrolyte and a monatomic catalyst modified diaphragm, and organic sulfur comprises dimethyl disulfide, tert-butyl disulfide, diphenyl disulfide, p-p-toluene disulfide, bis (2-nitrophenyl) disulfide, dibenzyl disulfide, diallyl disulfide, 4, 4 '-dipyridyl disulfide, 2, 2'-dithiobipyridine, 1, 2, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3 The low-temperature lithium-sulfur battery is one or more of 1, 1 '-dithiobis (caprolactam), 3, 3'-dithiobis (1-propanesulfonic acid) disodium salt, 2, 2 '-[dithiobis (methylene)] difuran, 3, 3'-dithiobis (propionitrile) and carbon disulfide. And the organic sulfur is added into the electrolyte to generate an intermediate product organic polysulfide through interaction between the organic sulfur and the polysulfide so as to realize depolymerization of polysulfide clusters in a low-temperature environment.

The present application relates to a kind of electrochemical method for synthesizing adiponitrile with propionitrile as raw material.Adopt metal Au doped platinum group metal as anode.Propionitrile, water, supporting electrolyte, inorganic salt are mixed according to certain proportion, electrolysis reaction is carried out in diaphragmless electrolytic cell, and adiponitrile is obtained by directly refining electrolyte oil phase.The process flow is short, three wastes are less, conditions are mild, cost is extremely low, and it has extremely high industrialization prospect.

This invention relates to pharmaceutical formulations for topical skin application comprising (R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile, or a pharmaceutically acceptable salt thereof, and use in the treatment of skin disorders.

The application discloses a preparation method of 2,2-diisopropylpropionitrile and belongs to the technical field of food additive intermediate synthesis. The method comprises the following steps: S1, adding sodium amide, a solvent and a catalyst into a reactor, stirring until being uniformly dispersed, and obtaining a reaction system; S2, uniformly mixing 2,3-dimethylbutyronitrile and 2-bromopropane to form a premix; dropping the premix into the reaction system, continuing to stir for 0.5-1 hours after dropping is completed; S3, adding deionized water into the reaction system to quench the reaction; after quenching the reaction, cooling and stirring the reaction system, layering after standing, and reserving an upper organic phase; S4, transferring the organic phase into a distillation device, performing normal pressure distillation, and separating the solvent; the normal pressure distillation temperature is 60-90 DEG C; performing vacuum distillation on the organic phase after the normal pressure distillation, collecting a distillate, and obtaining a product. The prepared 2,2-diisopropylpropionitrile has high yield and high purity.

The invention relates to a method for synthesizing a diaveridine intermediate, which comprises the following steps: (a) adding dimethyl sulfoxide, potassium hydroxide and 3-dimethylaminopropionitrile into a reaction container, and heating to 65-75 DEG C; then adding veratraldehyde, and stirring to react for 2-3 hours to obtain a first reaction solution; and (b) adding ethanol and aniline into the first reaction solution, then dropwise adding an acid-containing solution, carrying out heat preservation reaction at 75-85 DEG C for 2-3 hours, cooling, crystallizing, and drying to obtain the diaveridine intermediate. Therefore, the side reaction for synthesizing the diaveridine intermediate can be inhibited, so that the reaction conditions are simplified, and the yield of the product is improved.

This invention relates to pharmaceutical formulations for topical skin application comprising (R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile, or a pharmaceutically acceptable salt thereof, and use in the treatment of skin disorders.

The utility model discloses a catalyst recovery device in a propionitrile production process, which comprises a support frame, an electromagnetic filtering reaction kettle arranged at the upper part of the support frame, and a fixed flange arranged at the upper part of the electromagnetic filtering reaction kettle, a connecting flange is arranged on the upper portion of the fixing flange, the connecting flange and the fixing flange are fixed through fixing bolts, and an electromagnetic filter mounting base is arranged in the center of the connecting flange. When used catalyst enters the electromagnetic filter, the catalyst is acted by a strong magnetic field, and catalyst particles are captured by the magnetic field and adsorbed in a specific area of the filter due to the fact that the catalyst particles generally have certain magnetism or can be attracted by the magnetic field. And non-magnetic liquid and gas components or liquid and gas components which are not easily attracted by a magnetic field continuously flow, pass through other parts of the filter and are discharged, and as time goes on, a certain amount of catalyst is accumulated on the electromagnetic filter, so that the catalyst can be conveniently recycled.

The application provides a beta-amino propionitrile purification device, and belongs to the technical field of purification devices. The device comprises a distillation tower, a steam outlet pipe is arranged at the top of the distillation tower, the steam outlet pipe is connected with a heat exchange box, a first serpentine pipe and a second serpentine pipe are arranged in the heat exchange box, a first discharge pipe is arranged on the heat exchange box, a reflux pipe is arranged at the bottom of the heat exchange box, one end of the first serpentine pipe is connected with an ammonia removal box, a second discharge pipe is arranged at the bottom of the ammonia removal box, the second discharge pipe is connected with the distillation tower, an exhaust pipe is arranged at the top of the ammonia removal box, a first heating element is arranged in the ammonia removal box, 3-amino propionitrile low-temperature mixture generated in the reaction is heated through the heat exchange box, then is further heated and ammonia is removed through the ammonia removal box, so that the mixture is heated and ammonia is removed by using high-temperature steam in the distillation tower, energy consumption is reduced, the removed ammonia can be made into ammonia water and reused, and raw material waste is reduced.

The application provides an application of 3-(methylsulfonyl) propionitrile in preparation of a medicine for treating peripheral nerve adhesion diseases, relates to the field of biomedical technology, and is verified through a sciatic nerve adhesion mouse model that 3-(methylsulfonyl) propionitrile can effectively reduce the adhesion degree of nerves and peripheral tissues, and can significantly improve muscle atrophy symptoms; compared with the traumatic and high recurrence rate of surgical treatment, the drug is a non-invasive or minimally invasive treatment, has good patient tolerance, can effectively reduce treatment risks and rehabilitation costs, and has wider clinical applicability. Secondly, the drug plays a treatment effect through a double action mechanism: on the one hand, adhesion formation is inhibited, and nerve compression is released; on the other hand, nerve myelin sheath regeneration can be promoted, myelin sheath structure integrity is improved, nerve conduction velocity is improved, and the synergistic effect of 'adhesion release + nerve repair' is realized. Animal experiments prove that the drug can significantly improve the motion balance ability and gait function of model mice.