152 results about "Propionitrile" patented technology

The invention relates to a perfluoro wide-temperature electrolyte for a lithium battery and application thereof, the wide-temperature electrolyte comprises a lithium salt, an additive and a plurality of perfluoro mixed solvents, the electrolyte capable of stably working in a wide temperature range (-80-80 DEG C) is successfully constructed, and the excellent electrochemical performance of the lithium battery at the wide temperature is realized. The electrolyte additive disclosed by the invention mainly comprises one or more of hexafluoroisopropoxy cyclotriphosphazene, 3-(2, 2, 2-trifluoroethoxy) propionitrile, 3-(2, 2, 2-trifluoroethoxy) butyronitrile, 3, 4-fluoroethylene sulfate and 4-trifluoromethyl-ethylene sulfate, and the fluorine-containing additive is good in flame retardant effect, moderate in viscosity, good in system compatibility, good in corrosion resistance and good in corrosion resistance. And a protective film can be formed on the surface of the positive electrode of the lithium battery, so that the high-pressure and high-temperature cycle performance of the battery is improved, the electrochemical performance of the battery is not influenced at all, the self-extinguishing time of the electrolyte is obviously shortened, the flame retardant property and the conductivity are excellent, the overcharge resistance of the lithium ion battery is also obviously improved, and the safety performance of the battery is improved.

The invention relates to a sodium ion battery and a nitrile-based electrolyte thereof. The electrolyte comprises: a solvent formed by fluoroethylene carbonate and at least one selected from the group consisting of dinitrile, 3-methoxypropionitrile, isobutyronitrile, valeronitrile, ethylene glycol bis (propionitrile) ether and 4-cyano tetrahydropyran, wherein the volume fraction of fluoroethylene carbonate is 5-20%; and at least one sodium salt selected from the group consisting of sodium hexafluorophosphate, sodium trifluoromethanesulfonate, bis (trifluoromethylsulfonyl) imide sodium and bis (fluorosulfonyl) imide sodium, with a concentration of 2.0-4.0 mol L <-1 >. The electrolyte provided by the invention can simultaneously stabilize an interface between a positive electrode and a negative electrode, and has reasonable ionic conductivity and high electrochemical stability.

The invention provides a secondary battery and an electronic device, the secondary battery comprises an electrolyte and an isolating membrane, the electrolyte comprises a lithium salt additive and ethylene glycol bis (propionitrile) ether, based on the total mass of the electrolyte, the mass percentage content of the lithium salt additive is A%, the mass percentage content of the ethylene glycol bis (propionitrile) ether is B%, and 0.035 < = A / B < = 20; the lithium salt additive meets at least one of the following characteristics: a, the lithium salt additive comprises lithium bis (fluorosulfonyl) imide, wherein A is more than or equal to 0.1 and less than or equal to 2.5; b, the lithium salt additive comprises lithium tetrafluoroborate, and 0.1 < = A < = 2.5; the isolating membrane comprises a base material layer, the porosity of the base material layer is P%, and P is larger than or equal to 15 and smaller than or equal to 35. The electrolyte and the isolating membrane are adopted, and the A / B value, the A value and the P value are regulated and controlled in the application range, so that the secondary battery has relatively good low-temperature floating charge performance, safety performance and overcharge resistance under high temperature and high pressure.

The invention belongs to the technical field of batteries, and discloses a self-healing electrolyte for decoupling mechanical strength and conductivity and a preparation method thereof. The self-healing electrolyte with the mechanical strength and the conductivity decoupled comprises a polymer skeleton and solvent molecules used for transmitting lithium ions, the polymer skeleton is formed by copolymerizing two monomers, namely methacrylamide for providing a hydrogen bond donor and methyl methacrylate for providing a hydrogen bond acceptor according to a certain proportion in a free radical polymerization manner under the action of an initiator; the solvent molecule is fluorocyclopropionitrile capable of competing for lithium ions on a polymer chain. Before polymerization, a polymer monomer, an initiator and solvent molecules are mixed according to a certain proportion, lithium salt is added, and the solvent molecules are locked in a polymer skeleton in an in-situ polymerization mode. The gel electrolyte provided by the invention has the advantages of high conductivity, high mechanical strength and certain self-healing capability, and can be used for lithium ion batteries and lithium metal batteries.

The invention discloses a low-concentration ether electrolyte adaptive to a high-voltage high-nickel ternary lithium ion battery, a preparation method of the low-concentration ether electrolyte and the lithium ion battery, and relates to the technical field of batteries. The ether electrolyte comprises a solvent and a solute; the solvent comprises an ether solvent, and is specifically at least one of 4-cyano tetrahydropyran, 2-(tetrahydro-2H-pyran-4-yl) acetonitrile, 2-methoxyacetonitrile, 2-ethyoxyl acetonitrile, 3-methoxypropionitrile, 3-ethyoxyl propionitrile, 3-butoxyl propionitrile, ethylene glycol bis (propionitrile) ether and 3-{2-[2-(2-cyano ethyoxyl) ethyoxyl] ethyoxyl} propionitrile. The ether solvent contains cyano groups, the strong electronegativity of the cyano groups enables the cyano groups to be coordinated with transition metal ions in the ternary material, and the cyano groups are preferentially adsorbed at the interface of the positive electrode material, so that the arrangement of solvent molecules at the interface has directivity, the proportion of ether oxygen bonds and carbon hydrogen atoms in double electric layers is reduced, and the performance of the positive electrode material is improved. And the sites which are easy to generate dehydrogenation reaction in the molecules are far away from the high-voltage positive electrode interface which is easy to generate oxidation reaction.

The invention provides a secondary battery and an electronic device, the secondary battery comprises an electrolyte and an isolating membrane, the electrolyte comprises a lithium salt additive and ethylene glycol bis (propionitrile) ether, based on the total mass of the electrolyte, the mass percentage content of the lithium salt additive is A%, the mass percentage content of the ethylene glycol bis (propionitrile) ether is B%, 0.035 < = A / B < = 20, and 0.005 < = B < = 2.9; the lithium salt additive meets at least one of the following characteristics: a, the lithium salt additive comprises lithium bis (fluorosulfonyl) imide, wherein A is more than or equal to 0.1 and less than or equal to 2.5; b, the lithium salt additive comprises lithium tetrafluoroborate, and 0.1 < = A < = 2.5; the isolating membrane comprises a base material layer, the porosity of the base material layer is P%, and P is larger than or equal to 15 and smaller than or equal to 35. The electrolyte and the isolating membrane are adopted, and the A / B value, the A value, the B value and the P value are regulated in the application range, so that the secondary battery has relatively good low-temperature floating charge performance, safety performance and overcharge resistance under high temperature and high pressure.

The invention discloses a synthesis method of a felinone intermediate, and relates to the technical field of medicine synthesis. The synthesis method comprises the following steps: firstly, taking a 500ml four-neck flask, adding 200ml of dichloromethane, adding 40g of 3-hydroxypropionitrile, finally adding 5g of a DMAP solid material, and stirring for 1 hour; continuously dropwise adding 50 g of ketene dimer, and after temperature-controlled dropwise adding is completed, carrying out heat preservation reaction for 2 hours to obtain a reaction solution; and taking the reaction liquid, washing with 200ml of saturated saline solution, preserving heat, taking the lower-layer material, washing with 200ml of purified water, preserving heat, taking the lower-layer material, finally washing with 200ml of saturated saline solution, taking the lower-layer material, distilling, and desolventizing to obtain the target product. The preparation method comprises the following steps: putting 40g of a target product and 200ml of DMF (Dimethyl Formamide) into a 500ml four-mouth flask, stirring, then adding 50g of 4-cyano-2-methoxybenzaldehyde into a constant-pressure dropping funnel and the like; the synthesis method is stable in reaction, low in raw material price, reasonable in synthesis route, basically free of by-products in the synthesis process, and high in target product purity.

The invention belongs to the technical field of synthesis of food additive cooling agent intermediates, and particularly relates to a method for efficiently preparing 2, 2-diisopropyl propionitrile. According to the method, the solubility of sodium amide is promoted through the complexing action of the nitrogen-containing organic solvent in the reaction process, the reaction rate is increased, the situation that ultralow-temperature conditions and pressure-resistant equipment need to be used in the reaction process is avoided, and the operation difficulty of the reaction is reduced. The technical scheme provided by the invention simultaneously has the advantages of a liquid ammonia method and a solvent method in the prior art, the production energy consumption is reduced, the reaction rate is accelerated, and the production safety coefficient is improved. The industrial production is favorably realized.

The invention belongs to the field of fine chemical engineering, and discloses a method for synthesizing 2, 3-dimethyl-2-isopropyl butyronitrile, which comprises the following steps of: adding an organic amine solvent into a high-pressure reaction kettle, adding sodium amide, sodium iodide and a phase transfer catalyst into the reaction kettle under the protection of nitrogen and in a stirring state, stirring for a certain period of time, and reacting for 2-3 hours to obtain 2, 3-dimethyl-2-isopropyl butyronitrile. Dropwise adding a mixed solution of propionitrile and 2-bromopropane into the reactor, controlling the dropwise adding speed and the reaction temperature, continuously reacting for a period of time after the dropwise adding is finished to obtain a reactant solution, cooling the reactant solution, adding water, standing for layering, collecting an organic phase, distilling the organic phase at normal pressure to recover a solvent, and rectifying at reduced pressure to obtain 2, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3-pentanediol. According to the method, the sodium iodide, the phase transfer catalyst and the organic amine have a synergistic effect, so that the reaction time is shortened, and the yield of the product is improved.

The invention belongs to the technical field of medicines, and relates to a preparation method of a rucotinib phosphate key intermediate, in particular to a preparation method of 3-cyclopentyl acrylonitrile. Comprising the following steps: reacting 3-cyclopentyl propionyl chloride with ammonia water to generate 3-cyclopentyl propionamide; 3-cyclopentyl propionamide is dehydrated in the presence of a dehydrating agent such as phosphorus oxychloride to generate 3-cyclopentyl propionitrile; in a certain solvent, 3-cyclopentyl propionitrile reacts with a halogenating reagent (NCS, NBS and the like) to generate 2-halogenated-3-cyclopentyl propionitrile; and finally, in a certain solvent, eliminating the 2-halogenated-3-cyclopentyl propionitrile under an alkaline condition to generate the target product 3-cyclopentyl acrylonitrile. The method is simple to operate, mild in condition, excellent in yield and quality and suitable for industrial production.

The invention provides a preparation method of hexafluoroisobutene, which comprises the following steps: firstly, reacting hexafluoroisopropanol with p-toluenesulfonyl chloride to generate an organic phase, then reacting with a cyano source to obtain 3, 3, 3-trifluoro-2-(trifluoromethyl) propionitrile, then reacting with an acid solution and a reducing agent in sequence to obtain hexafluoroisobutanol, and finally reacting with an acid solution and a reducing agent to obtain the hexafluoroisobutanol. And finally, carrying out alkali dehydration to generate hexafluoroisobutene. The preparation method provided by the invention is simple in process route and mild in reaction condition, the solvent used in the preparation process can be recycled, the pollution in the preparation process is reduced, and the preparation method is less in three wastes, environment-friendly and suitable for large-scale production.

The invention belongs to the technical field of chemical engineering, and discloses a cooling agent N, 2, 3-trimethyl-2-isopropyl butyramide and a synthesis method and application thereof, and the synthesis method comprises the following steps: adding propionitrile and isopropyl bromide into a reaction kettle, and reacting under the low-temperature liquid ammonia condition of-30-50 DEG C to obtain an intermediate DIPPN; carrying out purification and distillation on the intermediate DIPPN; reacting the purified and distilled intermediate DIPPN with dimethyl polyphosphate at the temperature of 100-140 DEG C, neutralizing with acid, separating, and filtering to obtain a crude product; the crude product is crystallized and dried, and the cooling agent N, 2, 3-trimethyl-2-isopropyl butyramide is obtained; the problem of low yield in the prior art is solved, and the problem of high acid value of amidation of methanol and concentrated sulfuric acid as a catalyst in the prior art is also solved.

The present application relates to the field of frother, in particular to a kind of copper flotation collector frother and preparation method thereof, by weight parts, including the following raw materials: N,N-dibutyl dithiocarbamic acid propyl cyanurate 100-120 parts, O-butyl-N-isobutyl thiopropyl carbamate 12-18 parts, xanthate 12-18 parts, phosphate ester polypropylene glycol ether 15-20 parts, modified betaine 5-8 parts, alcohol ether 3-5 parts, slime inhibitor 1-3 parts, alcohol ether carboxylate 2-5 parts, sorbitan monooleate 0.8-1.2 parts. Through the synergies of each raw material, the collector capacity, selectivity in copper flotation process can be effectively improved, and the reagent stability is good.

The application belongs to the field of chemical industry, and particularly relates to a preparation method of N,N,N',N'-tetramethyl diacrylamine, which comprises the following steps: hydrogenation reaction is carried out by introducing hydrogen into an amine group propyl cyanide compound, a dimethylamine aqueous solution and a catalyst; under the protection of inert gas, solid-liquid separation (filtration) is carried out on the obtained hydrogenated material, so that a filtrate and a filter cake are obtained; and the filtrate is subjected to rectification, so that N,N,N',N'-tetramethyl diacrylamine (2(DMAP)A) is obtained. The application has the advantages of simple process, mild conditions, green environmental protection, high product yield and facilitation of industrial production.

The invention discloses a tetrazine probe synthon and a preparation method and application thereof.The preparation method comprises the following steps that under the inert atmosphere, diethyl cyanomethylphosphonate, 3-hydroxypropionitrile, 3-mercaptopropionic acid and hydrazine hydrate are mixed and then react at the room temperature, a sodium nitrite solution is added after the reaction is finished, then acid is continuously added till the reaction system reaches acidity, and a tetrazine probe synthon product is obtained; continuously reacting to obtain an intermediate; and dissolving the intermediate in a solvent in an inert atmosphere, adding triethylamine, slowly adding methanesulfonyl chloride, and reacting at room temperature to obtain the tetrazine probe synthon shown in the formula I. The invention further discloses a preparation method of the tetrazine probe synthon. The tetrazine probe synthon provided by the invention can perform series Heck reaction and HWE reaction, so that controllable combination of functional groups on two sides of a tetrazine coupling probe is realized under mild reaction conditions, and the functional groups on two sides are designed according to actual requirements to regulate and control photophysical properties of the probe. A brand new way is provided for developing a high-performance biological orthogonal fluorescent probe.

The present disclosure is directed to polymorph Form 1 of 1H-pyrazole-1-propanenitrile, β-(cyclopentyl-2,2,3,3,4,4,5,5-d8)-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-, (βR)-, phosphate (1:1) (deuruxolitinib phosphate). Also disclosed are methods of treatment using polymorph Form 1 of deuruxolitinib phosphate and methods of making polymorph Form 1 of deuruxolitinib phosphate.

The invention discloses a preparation method of a cyanoborate lithium salt derivative, which comprises the following steps: 1, mixing an alcohol compound, a lithium source compound, a boron source compound and trimethylsilyl cyanide in a polar organic solvent, and filtering after complete reaction to obtain a cyanoborate crude product filtrate; the alcohol compound is selected from one of 2, 2, 2-trifluoroethanol, 2, 2-difluoroethanol, 2-fluoroethanol, 3-hydroxypropionitrile, allyl alcohol and propargyl alcohol; the lithium source compound is selected from one of lithium carbonate and lithium hydroxide; the boron source compound is selected from one of boric acid, diboron trioxide and boron tribromide; the reaction temperature is controlled to be 0-120 DEG C; and 2, adding an inert organic solvent into the cyanoborate crude product filtrate for crystallization, and performing vacuum drying to obtain a finished product of the cyanoborate lithium salt. The method has the advantages of high yield and purity, simple process, convenience in operation and low cost, and is extremely suitable for industrial production.

To provide a new pharmaceutical use of 3-[(3S,4R)-3-methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,6-diazaspiro[3.4]octan-1-yl]-3-oxopropanenitrile for the treatment of cutaneous lupus erythematosus.SOLUTION: There are provided a therapeutic or preventive agent for cutaneous lupus erythematosus, containing 3-[(3S,4R)-3-methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)- 1,6-diazaspiro[3.4]octan-1-yl]-3-oxopropanenitrile as an active ingredient, and a pharmaceutical formulation thereof.SELECTED DRAWING: None

This invention relates to pharmaceutical formulations for topical skin application comprising (R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile, or a pharmaceutically acceptable salt thereof, and use in the treatment of skin disorders.

The invention provides a preparation method of a hydrogenation catalyst and a method for preparing trimethyl hydroxyethyl propane diamine by using the catalyst. A carrier of the catalyst is a bimetallic oxide carrier, active components of the catalyst are Pd and Ni, and auxiliaries are selected from chromium, manganese, lithium, tin, iron and cerium. The catalyst can be used for preparing trimethyl hydroxyethyl propane diamine by taking N, N-dimethylaminopropionitrile, N-methylethanolamine and hydrogen as raw materials, and is high in activity, high in selectivity, stable in performance and long in service life. In addition, a new reaction route is adopted, ethylene oxide is not used, the risk of the process can be reduced, in addition, raw materials are cheap and easy to obtain, reaction conditions are mild, the product yield is high, the production cost is low, economical efficiency is good, and good industrial application prospects are achieved.

The present application relates to the field of chemical synthesis, in particular to a synthesis method of N-oxobutane acetamide and derivatives thereof.The synthesis method comprises the following steps: reacting a phenone compound with a nitrile compound, an acid and a reaction solvent to obtain the N-oxobutane acetamide and derivatives thereof; the phenone compound is p-bromophenone, p-fluorophenone, p-chlorophenone, p-iodophenone, p-cyanophenone, 3,4-dimethylphenone or 2-naphthaldehyde; the nitrile compound is acetonitrile, 3-chloropropionitrile, dichloroacetonitrile or deuterated acetonitrile; the acid is CF3SO3H or BF3; and the reaction solvent is acetonitrile or dichloroethane.The present application directly constructs the N-oxobutane acetamide and derivatives thereof in one step with the nitrile compound as the only nitrogen source, and has the advantages of cheap and easily available raw materials, mild conditions, high yield and easy scale-up production.

The application discloses a method for synthesizing 3-hydroxypropionitrile with high selectivity, and belongs to the technical field of organic synthesis. In the presence of a hydrophobic solvent and an alkaline catalyst, acrylonitrile and water are reacted to generate 3-hydroxypropionitrile. In the reaction system, the hydrophobic solvent and water constitute a two-phase reaction system, acrylonitrile is dissolved in the hydrophobic solvent, and the generated 3-hydroxypropionitrile is dissolved in water. The application introduces the hydrophobic solvent into the reaction system, increases the protection of the product 3-hydroxypropionitrile, reduces the further contact of the product 3-hydroxypropionitrile with acrylonitrile to generate di(cyanoethyl) ether, improves the selectivity of the reaction, and further improves the yield of 3-hydroxypropionitrile. The yield of 3-hydroxypropionitrile can reach about 72%, and the hydrophobic solvent and unreacted acrylonitrile can be recycled and used, thereby reducing the production cost. The application has the advantages of simple process, good reaction selectivity, high yield of the obtained product and low cost.

The present disclosure relates to a polymorph Form 1 of ([beta] R)-[beta]-(cyclopentyl-2, 2, 3, 3, 4, 4, 5, 5-d8)-4-(7H-pyrrolo [2, 3-d] pyrimidin-4-yl)-1H-pyrazol-1-propionitrile phosphate (1: 1) (deuterated ruxolitinib phosphate), in particular, to a polymorph Form 1 of ([beta] R)-[beta]-(cyclopentyl-2, 2, 3, 3, 4, 4, 5, 5-d8)-4-(7H-pyrrolo [2, 3-d] pyrimidin-4-yl)-1H-pyrazol-1-propionitrile phosphate (1: 1). Also disclosed are methods of treatment using the polymorph Form 1 of deuterated rusotinib phosphate and methods of producing the polymorph Form 1 of deuterated rusotinib phosphate.

The present invention provides a malonate salt form of (R)-3-(4-(7H-pyrrolo [2, 3-d] pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropionitrile and a crystal form thereof, the salt or crystal form can be used to modulate the activity of JAK kinase, and can be used to treat diseases associated with the activity or expression level of JAK kinase, such as JAK kinase. Including, for example, immune-related diseases, skin diseases, myeloproliferative disorders, cancer, and other diseases.

The invention relates to the technical field of organic synthesis, in particular to a synthesis method of N, N-dimethyl-1, 3-propane diamine. The synthesis method comprises the steps that N, N-dimethyl propionitrile and a modified Raney nickel-cobalt catalyst are mixed for a catalytic hydrogenation reaction, and the modified Raney nickel-cobalt catalyst is prepared from 0.1%-2.5% of chromium, 80%-85% of cobalt, 0.1%-2.5% of nickel and 7%-8% of aluminum. According to the synthesis method, caustic alkali or liquid ammonia does not need to be added, the raw material conversion rate is increased, the requirements of high-end products with ultra-purity (99.8%) and low moisture (less than or equal to 0.05%) can be met, and the impurity introduction risk is reduced.

The invention discloses a preparation method of tris (2-cyanoethyl) phosphate, which comprises the following steps of: 1, adding 3-hydroxypropionitrile, an organic alkali acid-binding agent and a reaction organic solvent which is one of dichloromethane and dichloroethane into a reaction container, and reacting at the temperature of between 20 and 30 DEG C for 1 to 3 hours; controlling the temperature not to exceed 20 DEG C, dropwise adding a mixture formed by phosphorus trichloride and a reaction organic solvent, after dropwise adding is completed, performing heating reflux reaction, and after the reaction is completed, performing suction filtration to remove generated organic alkali hydrochloride so as to obtain filtrate; and 2, controlling the temperature of the filtrate obtained in the step 1 at 30-40 DEG C, introducing oxygen for reaction until the reaction is finished, and removing the reaction organic solvent to obtain the final product tris (2-cyanoethyl) phosphate. The method has the advantages of simplicity in operation, mild and controllable reaction, high product purity and suitability for industrial popularization.

The present invention relates to the treatment of cutaneous lupus erythematosus. The problem to be solved by the invention is to provide a new pharmaceutical use of 3-[(3S,4R)-3-methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,6-diazaspiro[3,4]octan-1-yl]-3-oxopropanenitrile. A therapeutic or preventive agent cutaneous lupus erythematosus, containing 3-[(3S,4R)-3-methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,6-diazaspiro[3,4]octan-1-yl]-3-oxopropanenitrile as an active ingredient, and a pharmaceutical formulation thereof.

The invention discloses a novel ketorolac synthesis method, which takes 2-(1H-pyrrole-1-yl) propionitrile as a raw material, and ketorolac is obtained through the steps of cyclization reaction, benzoylation reaction, Vanderson reaction, hydrolysis reaction and the like.