24 results about "Benzyl cyanide" patented technology

This invention relates to a trifluoromethyl-substituted pyrene-phenylacetonitrile derivative, its preparation method, and its application. A trifluoromethyl-substituted pyrene-phenylacetonitrile derivative has the structural formula: [formula omitted]. The preparation method involves dissolving 1-pyrene formaldehyde, the corresponding trifluoromethylphenylacetonitrile, and an alkaline catalyst in an organic solvent, and carrying out a Knoevenagel condensation reaction under heating conditions. The reaction product is then post-treated to obtain the pyrene-phenylacetonitrile derivative. The application of a trifluoromethyl-substituted pyrene-phenylacetonitrile derivative in electrical storage devices is also discussed. This invention achieves precise control of storage performance by introducing trifluoromethyl groups at different positions on the benzene ring of the pyrene-phenylacetonitrile backbone, providing a novel design approach for developing new multi-level electrical storage materials. The synthesis route is concise and has broad application prospects in the field of high-density non-volatile memory.

The invention provides a method for detecting taurine in magnesium acetyltaurate, which comprises the following steps: (1) derivatization treatment: carrying out derivatization reaction on a derivatization reagent and magnesium acetyltaurate containing taurine under an alkaline condition to obtain a derivatization product; (2) detection: detecting the derivatization product in the step (1) by adopting a high performance liquid chromatography-ultraviolet detector; wherein the derivatization reagent is selected from the group consisting of 2, 4-dinitrofluorobenzyl cyanide. The determination method has the advantages of high sensitivity, good specificity, simple operation, high accuracy, good reproducibility, good stability and low cost, improves the quality standard of taurine detection in magnesium acetyltaurate, can strictly control the quality of taurine in magnesium acetyltaurate, ensures the safety and reliability of magnesium acetyltaurate, and has a wide application prospect. The practical significance is realized.

The invention relates to the technical field of chemical synthesis, and provides a 1H-pyrazole-5-alcohol copper complex as well as a synthesis method and application thereof. The molecular formula of the complex is Cu (L) 2, and L is a dehydrogenated anion ligand of 3-methyl-1-phenyl-4-(1-imido-2-phenethyl)-1H-pyrazole-5-alcoholic hydroxyl group. The synthesis method comprises the following steps: adding 3-methyl-1-phenyl-5-pyrazolone, copper acetate monohydrate and phenylacetonitrile into a hydrothermal container, sealing, carrying out constant-temperature reaction in a drying oven, cooling to room temperature, and volatilizing filtrate to obtain the green flaky Cu (L) 2 single crystal, the invention also provides a method for realizing the introduction of the 4-position imine group of the 5-pyrazolone by using the nitrile. The complex Cu (L) 2 provided by the invention has an excellent inhibition effect on three tested strains.

The invention discloses a synthesis method of hydrogen isotope labeled vortioxetine. The synthesis method comprises four steps of reaction: construction of diaryl sulfide, selective deuteration of methyl, selective reduction of cyano and coupling reaction of carbon-nitrogen bonds. According to the key step, deuterated dimethyl sulfoxide is used as a deuterium source under the catalysis of a methyl selective deuterated alkali metal catalyst, and methyl deuterated dimethyl sulfoxide and a methyl benzene intermediate are selectively subjected to a methyl deuterated reaction. The method effectively avoids the harsh condition of low temperature for introducing a deuterated methyl scheme after aryl halogenated hydrocarbon lithium halide exchange and deuterated iodomethane reaction, avoids the generation of dehalogenation byproducts, and overcomes the defects that the product is difficult to purify, the reaction is difficult to amplify and produce and the like. The key step of the invention adopts a specific alkali metal salt as a catalyst to carry out methyl deuteration reaction, and combines cyanobenzene to selectively reduce and construct another methyl, so the method has the remarkable advantages of low cost, environmental protection, simple process and suitability for industrial production.

The invention discloses a preparation method of a Lamellarin key intermediate, which comprises the following steps: in the presence of a solvent and at 70-150 DEG C, carrying out reaction on 5, 6-dihydro-1, 2-diphenylpyrrolo [2, 1-a] isoquinoline or a derivative thereof, benzyl cyanide and a copper compound to prepare the Lamellarin key intermediate; the method is low in cost, raw materials are easy to obtain, reaction conditions are mild, reaction yield is high, purity is high, the process is simple and easy to implement and relatively environmentally friendly, the method is suitable for industrial production, related products are prepared for the fields of biology, pesticide and medicine, and the Lamellarin compound which is abundant in source and low in price is provided; .

The invention provides a donor-acceptor type covalent organic framework material B-COF photocatalyst and application thereof in synthesis of benzonitrile derivatives, and belongs to the technical field of catalytic chemistry. The B-COF can be prepared through solvothermal condensation of 2, 4, 6-triformyl phloroglucinol and a benzidine derivative, and is characterized in that a [100] crystal face diffraction peak appears at a position where 2theta is equal to 3.46 degrees in XRD (X-Ray Diffraction). The material can efficiently catalyze conversion from aromatic aldoxime to a benzonitrile derivative under light irradiation, and the thermal stability of the material is obviously superior to that of a traditional photocatalyst. According to the B-COF photocatalyst and the catalytic system thereof developed by the invention, the efficiency and the selectivity of photocatalytic organic conversion reaction are remarkably improved, and a new technical scheme is provided for developing an environment-friendly and sustainable chemical synthesis method.

This invention discloses a reverse electrically controlled dimming film based on a photopolymerizable monomer and a negative nematic liquid crystal system, and its preparation method. The film includes a liquid crystal cell or a liquid crystal film, and a liquid crystal composite system infused within the liquid crystal cell or liquid crystal film. The liquid crystal composite system comprises 50.0–96.0 wt% of a negative nematic liquid crystal mixture, 4.00–50.0 wt% of a photopolymerizable monomer, and 0.2–10.0% of a photo-leaving photoinitiator by mass of the total photopolymerizable monomer. The photo-leaving photoinitiator is an o-nitrophenyl compound, a benzothiophene iminophenylacetonitrile compound, or a mixture thereof. The reverse electrically controlled dimming film prepared by this invention has a visible light transmittance of less than or equal to 1% under a low-frequency electric field, a near-infrared light transmittance of less than or equal to 22%, and a visible light and near-infrared light transmittance of greater than or equal to 80% in the un-energized state. It has low energy consumption, low driving voltage and response time, and the preparation process is simple, energy-saving, and environmentally friendly.

This invention belongs to the field of organic synthetic chemistry and discloses a method for the catalytic synthesis of α-alkylbutadiene nitrile compounds. Using styrene and phenylacetonitrile compounds as substrates, the method involves a catalytic reaction at 120-160°C for 6-16 hours under a nitrogen atmosphere, with the combined action of a palladium catalyst and KOH, to obtain α-alkylbutadiene nitrile compounds. This invention achieves the α-alkylation of phenylacetonitrile without the need for complex metal complexes as catalysts or excessive alkylation substrates. Furthermore, the catalyst of this invention can be reused multiple times, exhibits good stability, and the reaction is mild.

The invention belongs to the technical field of organic polymer materials, and discloses a diamine monomer containing an acrylonitrile structure and black polyimide synthesized by the diamine monomer. The black diamine monomer containing the acrylonitrile structure is synthesized by taking a monomer containing a benzyl cyanide structure and a monomer containing a benzaldehyde structure as raw materials. And carrying out polycondensation on the synthesized diamine monomer (added with other diamines) and a dianhydride monomer to obtain a polyamide acid solution, and preparing the black polyimide by a thermal method or a chemical imine method. The diamine monomer containing the acrylonitrile structure with the large-plane conjugated structure and the light absorption effect is used for preparing the intrinsic black polyimide, the method is simple and efficient, and the black polyimide can be prepared without adding or coating any black substance. The prepared black polyimide is excellent in shading performance and heat resistance and has wide application value in the fields of electronic industry, aerospace, instrument communication and the like.

The invention belongs to the technical field of essences, and particularly relates to a long-acting cooling essence based on synthesized WS-3 or derivatives thereof and peppermint oil and a preparation method of the long-acting cooling essence. The essence is prepared from the following components in parts by weight: 10.2 to 20.2 parts of benzyl alcohol, 10 to 12 parts of propylene glycol, 0.5 to 1.5 parts of peppermint oil, 0.6 to 0.9 part of WS-3, 0.2 to 0.5 part of WS-23, 2 to 5 parts of N-p-phenylacetonitrile mint alkyl formamide, 2 to 2.5 parts of an omphisa fuscidentalis hampson extract and 3 to 3.5 parts of a soothing composition. The prepared essence is rich in fragrance, good in halitosis covering effect, long in lasting time, capable of relieving and free of irritation and high in storage stability and has a long-acting cooling effect.

The invention relates to a preparation method and application of a novel benzyl cyanide ester insect covalent pheromone, the benzyl cyanide ester insect covalent pheromone is a compound with the following structural figure (1), R-C = O is allyloyl, 2, 5-dioxo-2, 5-difluoro-2, 5-difluoro-2, 5-difluoro-2, 5-difluoro-2, 5-difluoro-2, 5-difluoro-2, 5-difluoro-2, 5-difluoro-2, 5-difluoro-2, 5-difluoro-2, 5- wherein, in the formula I, R1, R2, R3, R4, R5, R6, R7, R7, R7, R8, R8, R8, R8, R8, R8, R8, R8, R8, R8, R8, R8, R8, R8, R8, R8, R8, R8, R8, R8, R8, R8, R8, R8, R8, R8, R8, R8, R8, R8, R8, R8, R8 Wherein R1, R2, R3, R4, R5 are cyano or ethyl cyano or hydrogen, hydrogen or cyano or ethyl cyano, hydrogen or cyano or ethyl cyano, hydrogen or cyano or ethyl cyano, hydrogen or cyano or ethyl cyano, hydrogen or cyano or ethyl cyano, hydrogen or methoxyl; y is nitrogen or oxygen; and n is 0, 1, 2 or 3.

The invention discloses a phenylacetonitrile melt crystallization purification method, and belongs to the technical field of phenylacetonitrile purification methods. The acetonitrile crude product comprises the following raw materials: 75-79% of benzyl cyanide, 15-17% of benzyl alcohol, 3-5% of benzylamine and 2-4% of benzaldehyde; starting a program temperature control system and putting the filtered clear liquid into a melt crystallizer; the final benzyl cyanide crystal is obtained through initial cooling and crystal growing, heating and sweating, cooling and crystal growing and heating and sweating, and cooling and crystal growing and heating and sweating for the third time, and the purity of the final benzyl cyanide crystal is 99.90%-99.94%. The method is based on the fact that impurities have different partition coefficients between benzyl cyanide crystals and molten liquid. Under slow cooling, phenylacetonitrile with higher purity is preferentially crystallized, and impurities are discharged into mother liquor. The sweating operation further utilizes the characteristic that the melting point of the defect part in the crystal is lower, and the defect part is removed through precise temperature control, so that the ultra-high-purity crystal is obtained. A new scheme is provided for resource recovery, and the method is particularly suitable for recovering high-purity benzyl cyanide from production waste liquid or by-products with complex components.

The invention belongs to the field of organic synthesis, and particularly relates to a synthetic method of 2-amino-3, 4, 6-triarylpyridine. A phenylacetonitrile compound as shown in a formula 1, a benzonitrile compound as shown in a formula 2 and a phenylacetylene compound as shown in a formula 3 are mixed with an organic solvent (1, 4-dioxane or tetrahydrofuran or methyl tert-butyl ether or cyclopentyl methyl ether) in a strong base (bis (trimethylsilyl) potassium amide), and the 2-amino-3, 4, 6-triarylpyridine as shown in a formula 4 is synthesized through reaction. The adopted raw materials are simple and easy to obtain, the method for synthesizing the 2-amino-3, 4, 6-triarylpyridine through the one-pot method is constructed, and the method has the advantages of being simple in synthesis method, economical, environmentally friendly, wide in application range and the like.

The application belongs to the technical field of organic synthesis chemistry, and particularly relates to a method for synthesizing 2,3-diphenylpropionitrile compounds from benzyl cyanide compounds in one step. The application realizes C-C coupling reaction of benzyl cyanide compounds by synthesizing 2,3-diphenylpropionitrile compounds from benzyl cyanide compounds as substrates in one step under the action of Cu(I) / ETS-10. The synthesis method has simple conditions, and the target product can be efficiently synthesized without adding a complex noble metal complex as a catalyst, thereby providing a valuable reference for C-C coupling reaction of aromatic nitrile compounds.

The application discloses a method for preparing phenylacetonitrile based on a continuous flow dynamic microreactor. By regulating the flow rates of the two-phase reactants of benzyl chloride and sodium cyanide containing a phase transfer catalyst, the residence time of the reaction is regulated. Meanwhile, the flow rate ratio of the two-phase reactants is dynamically adjusted according to the real-time feedback of the yield of phenylacetonitrile, so that the fine control of the cyanation reaction is realized. The microreactor of the application is built-in with magnetic stirring. On the one hand, the microdroplets with excellent dispersibility are formed, which has excellent process intensification effect on the cyanation reaction, greatly improves the phase transfer catalytic efficiency, and makes the yield of phenylacetonitrile increase to more than 97%, and the reaction time is reduced to 30 minutes. The space-time yield is increased from 460 g / (m 3 ·min) of the tank process to 13000 g / (m 3 ·min), which is increased by about 30 times. On the other hand, the sodium chloride particles can be continuously broken, avoiding the blockage of the microchannel caused by the deposition and aggregation of sodium chloride particles, solving the problem that the ordinary microchannel reactor cannot cope with the high solid content system, and ensuring the long-period stable operation.

The invention provides a method for preparing o-methyl benzyl cyanide ketoxime through continuous flow, and belongs to the field of organic synthesis. The method provided by the invention comprises the following steps: when a continuous flow preheater, a continuous flow mixer and a continuous flow reactor reach a circulating temperature, starting each metering pump, and reacting to obtain o-methyl phenylacetonitrile ketoxime. According to the present invention, o-methylbenzyl cyanide is adopted as the raw material to prepare o-methylbenzyl cyanide ketoxime through the continuous flow process, such that the reaction can be ensured to be completed in a short time, and the obtained o-methylbenzyl cyanide ketoxime has high purity and high yield. The method disclosed by the invention is a method for efficiently and safely obtaining o-methyl benzyl cyanide ketoxime, and has a good application prospect.

The application discloses a kind of corrosion-resistant glass and preparation method thereof, it is related to glass field.The application is when preparing corrosion-resistant glass, glass plate is sequentially reacted with trimethoxy (thiophene-2-yl) silane, thiophene and 4-hydroxythiophene [2, 3-B] pyridine-5-methyl cyanide and 4-dimethylamino benzyl cyanide, and functionalized glass plate is prepared;Methyl methacrylate, acetyl acetic acid methyl methacrylate ethylene glycol ester, butyl acrylate and 1-allyl-4-(trifluoromethyl) benzene are polymerized, then mixed with 4-bromo-1-butene, irradiated, coated on functionalized glass plate, solidified, and corrosion-resistant glass is prepared.The corrosion-resistant glass prepared by the application has the ability of antibacterial, antistatic and aging resistance.

Methods for preparing substituted phenylacetonitrile and substituted phenylacetic acid are provided. The methods disclosed herein provide for yields of phenylacetic acid or derivatives thereof, as determined from benzoic acid starting materials, of greater than 75%, and require fewer steps or dangerous reagents and solvents than known methods. These substituted phenylacetic acids can be found for use in the preparation of novel active ingredients, such as GLP-1 receptor agonists, in the field of diabetes.

The application discloses a switch type acid discoloration cyanostilbene compound and a preparation method thereof, belongs to the preparation field of cyanostilbene compounds, and the cyanostilbene compound is an orange solid powder. The preparation method comprises the following steps: adding 4-(dimethylamino) isophthalaldehyde and anhydrous ethanol into a 250ml round-bottom flask, and then heating to fully dissolve the 4-(dimethylamino) isophthalaldehyde; adding 4-cyanophenylacetonitrile into the above solution, and after the 4-cyanophenylacetonitrile is fully dissolved, saturated potassium carbonate solution is added for catalysis, and the reaction is carried out at 75-80 DEG C for 1.5-2h, and then the reaction is tracked by using a thin layer chromatography method; after the reaction is completed, hot suction filtration is carried out, and then ethanol is used for elution, and finally, the cyanostilbene compound in the form of orange powder is obtained through drying. The method has the advantages of easy raw material, mild condition, rapid synthesis, green environmental protection, and the post-treatment avoids the loss of samples caused by extraction and column chromatography, and the yield is ensured.

The invention discloses a preparation method and application of a metalloporphyrin and metal disulfide coupled porous organic polymer, and relates to the field of materials. The preparation method comprises the following steps: adding 5, 10, 15, 20-tetra (4-formyl phenyl) porphyrin metal and a metal disulphide derivative containing benzyl cyanide into a solvent for dissolving, carrying out freezing-vacuum-unfreezing circulation, then carrying out sealed reaction until the reaction is complete, and carrying out filtering, washing and suction filtration on the product to obtain the metalloporphyrin and metal disulphide coupled porous organic polymer. The application method comprises the following steps: adding the obtained mixture of the porous organic polymer and the carbon nanotube into a Nafion ethanol solution, carrying out ultrasonic dispersion to obtain a suspension, dripping the suspension onto carbon cloth, drying the carbon cloth to serve as a working electrode, and carrying out CO2 electroreduction by taking Ag / AgCl as a reference electrode and a graphite rod as a counter electrode. The porous organic polymer is synthesized by adopting a Knoevenagel condensation reaction, and the intrinsic conductivity of the polymer and the adsorption activation of CO2 molecules are improved by virtue of a bimetal center, so that the porous organic polymer has excellent electrocatalytic CO2 reduction performance in a KHCO3 solution.

The present invention belongs to the technical field of chemical pharmaceutical preparation, specifically relating to a benzyl cyanide derivative, its preparation method, and application. The structural formula of the benzyl cyanide derivative is: #imgabs0#. This derivative exhibits significant inhibitory effects against a variety of bacteria, with the inhibition rate increasing with increasing concentration, providing strong support for the development of new antibacterial drugs. Furthermore, cell compatibility experiments have demonstrated the safety of this derivative in human fibroblasts, providing a safer option for its use in the pharmaceutical field. The preparation method utilizes green chemistry principles, avoiding the use of toxic solvents and reducing environmental pollution.

This invention relates to a novel isoflavone compound represented by formula (I), a method for preparing this compound, and its use in the preparation of neuroprotective small molecule drugs. The general chemical formula of this compound is shown in formula (I). The compound in formula (I) is prepared by reacting a polyphenolic compound with a substituted phenylacetonitrile, or by reacting a polyphenolic compound with a substituted phenylacetic acid. A series of neuroprotective activity experiments have demonstrated that the compound described in this invention possesses excellent neuroprotective activity, and the compound with the best activity also exhibits acetylcholinesterase inhibitory activity, making it suitable as a lead molecule for the development of neuroprotective and neurodegenerative disease drugs. The preparation process of this invention is simple, the raw materials are inexpensive and readily available, and the product has high purity. (I).

The invention relates to a novel isoflavone compound as shown in a formula (I), a preparation method of the compound and application of the compound in preparation of neuroprotective small molecule drugs. The chemical general formula of the compound is as shown in formula (I). The compound in the formula (I) is prepared by reacting a polyphenol compound with substituted phenylacetonitrile or by reacting the polyphenol compound with substituted phenylacetic acid. A series of neuroprotective activity experiments prove that the compounds have good neuroprotective activity, and the compounds with the best activity also have acetylcholin esterase inhibitory activity and can be used as lead molecules for development of neuroprotective and neurodegenerative disease drugs. The preparation process is simple, raw materials are cheap and easy to obtain, and the product purity is high. # imgabs0 # (I).

The present invention provides a method for preparing midanacin. This method uses readily available and inexpensive diphenylacetonitrile, 1,2-dibromoethane, and 2-methylimidazole as raw materials, and it is easier to control costs during large-scale production. By adopting the method of continuous feeding in a multi-step conversion through superposition and contraction, the process flow is streamlined and the production cycle is shortened. The purity of the finished product is above 99%, and the overall yield is 78-83%. Compared with the existing process, the material cost can be relatively saved by about 20%-30%. The process uses water and alcohols as solvents, which is more environmentally friendly and suitable for industrial production.