72 results about "Eucalyptol" patented technology

The invention relates to the technical field of pesticides, in particular to a pesticide composition, application thereof and a pesticide preparation. The pesticide composition comprises a first effective component and a second effective component, the first effective component is 1, 8-cineole, and the second effective component comprises at least one of flonicamid, cyantraniliprole, nitenpyram, flubendiamide, spirotetramat, pyriproxyfen, pymetrozine, dinotefuran and sulfoxaflor. The mass ratio of the first effective component to the second effective component is (50: 1)-(1: 100). Through the synergistic interaction of the first effective component and the second effective component, the prevention and treatment effect is remarkably improved, the prevention and treatment spectrum is expanded, and the field dosage can be greatly reduced; specifically, leaf back bemisia tabaci and trialeurodes vaporariorum can be well controlled, the control effect on bemisia tabaci, trialeurodes vaporariorum, thrips and the like is improved, and the application prospect is good.

A pest control composition includes from about 4 wt % to about 10 wt % of sodium lauryl sulfate; one or more C5 to C9 hydrotropic salt; from about 1 wt % to about 10 wt % of one or more active ingredients selected from the group consisting of corn mint oil, peppermint oil, spearmint oil, rosemary oil, thyme oil, citronella oil, clove oil, cedarwood oil, cinnamon oil, geranium oil, eugenol, 2-phenylethyl propionate, menthol, menthone, thymol, carvone, camphor, methyl salicylate, p-cymene, linalool, geraniol, cinnamyl acetate, cinnamic alcohol, cinnamaldehyde, citronellol, eucalyptol / 1,8-cineole, alpha-pinene, bornyl acetate, gamma-terpinene, and combinations thereof; and from about 60 wt % to about 95 wt % of water. The pest control composition exhibits a water peak in a 2H spectrum having a width encompassing 90% of the area of the entire water signal of about 50 Hz or more, as determined by the 2H NMR Method.

This invention discloses an anti-acne Propionibacterium acnes compound essential oil, its preparation method, and its application. The anti-acne Propionibacterium acnes compound essential oil is composed of the following components in the indicated mass percentages: 22%~28% helichrysum essential oil, 22%~28% sweet basil essential oil, 22%~28% eucalyptol rosemary essential oil, and 22%~28% true lavender essential oil. This invention achieves highly effective antibacterial activity against Propionibacterium acnes through a precise selection of four plant essential oils and a scientifically formulated compound. It also possesses multiple benefits including anti-inflammatory properties, promotion of skin cell regeneration, and a natural fragrance. Furthermore, the product is natural, safe, and has no side effects, is suitable for various skin types, and can be directly applied to the preparation of various acne-removing skincare products.

The invention discloses a preparation method of high-purity cinnamomum longepaniculatum essential oil, and belongs to the technical field of plant essential oil preparation. The method comprises the following steps: distilling and extracting fresh cinnamomum longepaniculatum leaves to obtain a crude cinnamomum longepaniculatum oil product; rectifying the crude cinnamomum longepaniculatum oil to obtain cinnamomum longepaniculatum essential oil; and adding ethanol and a crystallization accelerant into the cinnamomum longepaniculatum essential oil, and carrying out freezing crystallization treatment, so that components such as 1, 8-cineole in the cinnamomum longepaniculatum essential oil form crystals, and the aim of separating the crystals from other components is fulfilled. By adopting the process disclosed by the invention, the content of 1, 8-cineole in the essential oil can be effectively increased, so that the quality of the cinnamomum longepaniculatum essential oil is improved.

The invention provides a mild refreshing borneol essential oil compound as well as a preparation method and application thereof. The borneol essential oil compound is prepared from the following components in parts by weight: 1 to 50 parts of borneol, 0.1 to 50 parts of menthol, 1 to 10 parts of natural camphor, 0.1 to 0.5 part of herba dendrobii essential oil, 35 to 70 parts of carrier oil, 0.2 to 1 part of vitamin E, 1 to 3 parts of eudesmol, 0.2 to 1 part of limonene and 0.5 to 5 parts of cinnamomum camphora essential oil clathrate compound. The borneol essential oil compound prepared by the invention has the advantages of better stability, high essential oil retention rate, freshness and durability, mild components without skin irritation, and refreshing effect, and can be applied to preparation of products such as snorting essential oil, roll-on essential oil or vehicle-mounted fragrance and the like.

The application provides an island reef coral filler compaction pile and a construction method thereof. The construction method of the island reef coral filler compaction pile comprises the following steps: (1) using a weight to hammer the ground soil body to form a cylindrical hole; (2) first filling mixed sand and stone into the hole, the mixed sand and stone is composed of coral reef gravel and calcareous sand, then pouring a microbial curing liquid and a composite additive, the microbial curing liquid is composed of a composite bacterial liquid and seawater, the composite bacterial liquid is prepared from bacillus pasteurii, bacillus cereus and bacillus mucilaginosus, and the composite additive is composed of hydroxyl citronellal and eucalyptol; then using the weight to ram the filler; (3) repeating step (2) to ram and fill the pile hole to the ground to form the compaction pile. The construction method can significantly improve the quality of the compaction pile, significantly improve the single pile bearing capacity, and effectively reduce the relative usage amount of the microbial curing liquid.

The present application relates to a method for improving the content of isomontin in wasabi, and belongs to the technical field of plant effective component extraction and enrichment, comprising the following steps: the present application uses the L-phenylalanine solution added with 1,8-eucalyptol and Tween-80 for atomization treatment, blue light irradiation treatment and drying treatment at 70-90 DEG C on wasabi leaves in sequence, so as to improve the extraction amount of isomontin in wasabi leaves.

Insect repellent composition The invention relates to an insect repellent composition comprising: - p-menthane-3,8-diol and / or an essential oil selected from lemon eucalyptus essential oil and Eucalyptus globulus essential oil, - a repellent agent selected from beta-caryophyllene and eucalyptol, - a solvent, and which is characterized in that it further comprises an oil.

A pest control composition having from about 4 wt % to about 10 wt % of sodium lauryl sulfate, one or more C5 to C9 hydrotropic salt, from about 1 wt % to about 10 wt % of an active ingredient selected from the group consisting of corn mint oil, peppermint oil, spearmint oil, rosemary oil, thyme oil, citronella oil, clove oil, cedarwood oil, cinnamon oil, geranium oil, eugenol, 2-phenylethyl propionate, menthol, menthone, thymol, carvone, camphor, methyl salicylate, p-cymene, linalool, geraniol, cinnamyl acetate, cinnamic alcohol, cinnamaldehyde, citronellol, eucalyptol / 1,8-cineole, alpha-pinene, bornyl acetate, gamma-terpinene, and combinations thereof, and from about 60 wt % to about 95 wt % water. The pest control composition can exhibit a tan delta-1 value at a frequency of 1 Hz of from about 0.1 to about 2.

The invention provides refreshing compound essential oil as well as a preparation method and application thereof, and belongs to the technical field of application of natural products. The refreshing compound essential oil is prepared from the following raw materials in parts by volume: 7 to 10 parts of agilawood essential oil, 10 to 15 parts of peppermint essential oil, 9 to 15 parts of ravenalka essential oil, 6 to 10 parts of sweet basil essential oil, 5 to 8 parts of cypress essential oil, 8 to 14 parts of eucalyptol rosemary essential oil and 10 to 16 parts of lemon essential oil. Experiments prove that the compound essential oil has the effects of refreshing and restoring consciousness, and is good in in-vivo safety.

The present invention relates to a composition comprising delta-9-tetrahydrocannabinol (THC), alpha-bisabolol, guaiol, beta-caryophyllene and at least one terpene selected from the group consisting of linalool, alpha-humulene, nerolidol, caryophyllene oxide, alpha-pinene, camphene, beta-pinene, beta-myrcene, limonene, eucalyptol, ocimene, gamma-terpinene, terpinolene, alpha-terpinene, para-cymene, isopulegol and geraniol. The invention also relates to a pharmaceutical formulation comprising such composition. The pharmaceutical formulation according to the present invention may be used in medicine, specifically in the treatment and / or prevention of diseases associated with pain such as chronic cancer pain, somatic pain, visceral pain, central neuropathic pain, peripheral neuropathic pain or complex pain syndromes.

The invention provides a blood-sucking midge efficient repellent and a screening and identifying method thereof, and relates to the technical field of biology. According to the invention, an odor receptor gene FtaiOr1 which is highly expressed at the head of a female gnat is obtained through identification, and a transgenic drosophila melanogaster strain Or22ab- / -GAL4 which can be used for screening a blood-sucking midge repellent compound is constructed through heterologous expression of the gene in a drosophila melanogaster ab3A neuron; and UAS-FtaiOr1 (UAS-FtaiOr1). Six blood sucking midge repelling compounds (camphor, eudesmol, (+)-anisone, alpha-terpilenol, (S)-cis-verbenol and isoterpinene) are obtained by screening of the fruit fly strain. The compounds can be used independently or in a compounded manner, are friendly to non-target organisms and environment, can be directly applied to repelling and on-site prevention and control of blood sucking midges, and have important application value in the aspects of reducing midge bites and reducing the propagation risk of entomophilous diseases.

This invention discloses a method for separating terpinene from camphor oil. The method utilizes the byproducts after separating eucalyptol from camphor oil. Camphor oil is subjected to vacuum distillation to release components, yielding passivated eucalyptol liquid and byproducts. The passivated eucalyptol liquid is then crystallized using a melt crystallization method to obtain more passivated eucalyptol and byproducts. The byproducts are fed into a distillation column for further distillation. The byproducts are coarsely separated in the distillation column using corrugated packing. After coarse separation, terpinene with a purity of 80% is obtained. The 80% purity terpinene is then purified by molecular distillation to obtain 98% purity terpinene. This method aims to improve the problem of low added value of byproducts and the tendency of terpinene to polymerize during atmospheric pressure separation, making it difficult to improve purity, when comprehensively utilizing camphor oil resources.

The invention provides a high-yield cultivation and planting management method for raspberry tea, and relates to the technical field of raspberry tea planting, the high-yield cultivation and planting management method for the raspberry tea mainly adopts urea, plant cytokinin, a raspberry tea extract, 1, 8-cineole and polyglutamic acid as nutritional agent components for foliage spraying; brassin, aspirin and Huabao No.1 are adopted as root soaking liquid, and root (branch) soaking treatment is conducted on the raspberry tea seedlings before transplanting or cuttage; conventional topdressing is performed after transplanting and field planting, and a nutritional agent is sprayed on leaf surfaces in time after leaf picking. According to the method, the defects in the prior art are overcome, rooting, germination and vine growth of the raspberry tea can be effectively promoted, the shoot tip and stem leaf yield of the raspberry tea is improved, and the economic benefit of planting the raspberry tea is comprehensively improved.

The invention discloses a method for detecting the influence of aromatherapy on bile acid metabolism caused by liver and gallbladder damp-heat syndrome, the method performs computer information processing based on acquired data, and comprises the following steps: acquiring aromatherapy exposure dose data, and determining the concentrations and inhalation doses of key aromatic components such as camphor, borneol and cineole through a gas chromatography-mass spectrometry technology; the method comprises the following steps: acquiring serum bile acid spectrum data, and synchronously quantifying 24 bile acids and metabolites thereof through a liquid chromatography-tandem mass spectrometry technology; performing feature extraction on the data to obtain aromatherapy exposure quantity features and bile acid metabolism change features; performing three-step step-by-step feature selection by adopting T inspection, a lasso algorithm and a variance expansion coefficient; and inputting the optimal feature into a curative effect prediction model trained based on a machine learning algorithm to obtain an aromatherapy curative effect prediction result, so that objective evaluation and accurate prediction of an aromatherapy method are realized, and the model accuracy is not lower than 85%.

The application discloses a method for separating n-butyric acid in an aqueous solution by using eucalyptol and application thereof. According to the technical scheme, the eucalyptol is used as an extractant to extract the n-butyric acid in the aqueous solution, the n-butyric acid can be separated and extracted under relatively mild conditions, the separation efficiency is improved while the purity of the n-butyric acid is maintained, and the energy loss of the separation operation is reduced. The treated water body is high in safety, the residual amount of the eucalyptol and the n-butyric acid in the water is extremely low, and the wastewater can be discharged and recycled in a standard way.

The invention belongs to the technical field of pest control, and particularly relates to a cotton aphid control pharmaceutical composition and a pharmaceutical preparation. The pharmaceutical composition comprises the eucalyptol and the sulfoxaflor, and the mass ratio of the eucalyptol to the sulfoxaflor is (8-32): 1. The pharmaceutical composition has a synergistic effect on poisoning of cotton aphids, and the poisoning effect of the combined medicament of the eucalyptol and the sulfoxaflor in the mass ratio on the cotton aphids is obviously higher than that of a single medicament, and is not an additive effect.

The application relates to the technical field of daily chemicals, and particularly discloses a bacteriostatic and deodorizing fragrance composition as well as a preparation method and application thereof. The bacteriostatic and deodorizing fragrance composition is made of raw materials and comprises the following components: a chemical reaction type deodorizing fragrance base, a sensory modification and receptor blocking fragrance base and a bacteriostatic synergistic fragrance base. The chemical reaction type deodorizing fragrance base is a combination of one or more of citral, citronellal, decanal, damascone, ionone and methyl dihydrojasmonate; the sensory modification and receptor blocking fragrance base is a combination of one or more of menthol and its derivatives, linalyl acetate, dihydromyrcenol and eucalyptol; and the bacteriostatic synergistic fragrance base is a combination of one or more of farnesol, eugenol, thymol, tea tree oil and rosemary extract. The bacteriostatic and deodorizing fragrance composition can keep a better balance and coordination of the sensory modification, chemical deodorization and bacteriostatic components in the fragrance, and thus can exert excellent deodorization and bacteriostatic effects.

The invention relates to oral analgesic compositions for alleviation of perceived nicotine irritation through inhibition or blocking of nicotine activated receptors or ion channels in the gastrointestinal tract, including the oral cavity. The composition of the invention comprises one or more nicotine sources, one or more buffering agents, and at least two antagonists in an effective amount to inhibit or block nicotine agonist activation of Nicotinic Acetylcholine Receptors (nAChR) and / or Transient Receptor Potential (TRP) ion channels, the at least two antagonists being selected from the group consisting of a first antagonist comprising camphor or one or more compounds resembling camphor, a second antagonist comprising eucalyptol, and a third antagonist comprising (1R,2S,5R)—N-(4-Methoxyphenyl)-5-methyl-2-(1-methylethyl)cyclohexanecarboxamide (WS-12).

The invention belongs to the technical field of agricultural pest repelling, and particularly relates to an application of eudesmol and / or trans-2-hexenal in repelling megalustris megalustris. In order to solve the problems that the existing chemical prevention and treatment of the megalurothrips usitatus is easy to cause drug resistance enhancement, pesticide residues exceed the standard and the like, the invention firstly determines that eudesmol in zanthoxylum bungeanum volatile matters and trans-2-hexenal in tomato volatile matters have remarkable repelling activity on the megalurothrips usitatus, and determines the effective action concentration range of the eudesmol and the trans-2-hexenal. The eudesmol has a remarkable repelling effect when the volume ratio concentration is 10 <-2 > v / v and 10 <-3 > v / v, and has an extremely remarkable repelling effect when the volume ratio concentration is 10 <-1 > v / v; the trans-2-hexenal has an extremely remarkable repelling effect when the volume ratio concentration is 10 <-1 > v / v. The invention provides a new technical means for green repelling of the megalurothrips megalurothrips, which is helpful for reducing the use of chemical pesticides, reducing the risk of pesticide residues and ensuring the safe production of leguminous crops.

The invention discloses a new application of a natural product 1, 8-cineole, and the natural product 1, 8-cineole can be used as an inhibitor of pathogenic bacteria of Xanthomonas oryzae pv. Oryzae, Xanthomonas oryzae pv. Oryzae and basal rot pathogen of rice. The invention discloses the inhibition effect of 1, 8-cineole on plant pathogenic bacteria for the first time, and provides a theoretical basis for searching natural broad-spectrum antibacterial drugs. The new application of the 1, 8-cineole is defined, the application range of the 1, 8-cineole is widened, and a new way is provided for development of novel pesticides.

This invention belongs to the field of pharmaceutical formulation technology, specifically relating to a lozenge for refreshing the mind and freshening the breath, and its preparation method. The lozenge comprises a plain tablet and a shell. The plain tablet includes inner phase particles, an inner phase particle coating layer, and excipients: the inner phase particles use sodium carboxymethyl cellulose and crospovidone to construct an immediate-release framework, with immediate-release and sustained-release caffeine and theanine as stimulating ingredients, supplemented by poloxamer to enhance penetration, achieving rapid absorption and sustained release of caffeine, and the theanine alleviates the nerve stimulation caused by caffeine; the inner phase particle coating layer uses hydroxypropyl methylcellulose and hydroxypropyl cellulose to construct a sustained-release framework, with polyethylene glycol forming microporous channels to promote the sustained release of fermented ginsenosides, enhancing anti-fatigue ability to prolong the stimulating effect, and releasing eucalyptol and limonene to produce a cooling sensation and mask odor, supplemented by Lactobacillus rhamnosus to inhibit the growth of harmful bacteria in the mouth to reduce odor, thereby achieving the effects of rapid stimulating, long-lasting mental alertness, and fresh breath.

The invention discloses a preparation method of litsea coreana beer, which comprises the following steps: distilling and extracting litsea coreana to separate volatile aroma (camphor and cineole) and non-volatile components, thereby enhancing the flavor efficiency; according to the present invention, the Litsea coreana extract total liquid is added at the fermentation rear end, such that the tea flavor volatilization caused by high temperature is avoided, terpene substances (such as linalool) and polyphenol are maximally retained, and the fusion of the classical German-style wheat flavor and the Litsea coreana characteristic is achieved; the content of terpene substances (linalool and the like) and polyphenol is obviously increased; the antioxidant components enhance the health-care properties of the product and prolong the shelf life.

This invention relates to the field of mosquito repellent composition technology, specifically to a plant-based mosquito repellent composition and its preparation method, comprising Sophora flavescens extract, eucalyptol, montmorillonite glycol, and natural Echinacea purpurea extract; the natural Echinacea purpurea extract is an aqueous extract with a chicoric acid content ≥4%. The plant-based mosquito repellent composition and preparation method of this invention, through functional optimization of single components and synergistic formulation of multiple components, fundamentally solves the core problems of existing plant-based mosquito repellent products, such as poor mosquito repellent effect, short effective duration, and lack of skin soothing function, while also taking into account the product's naturalness and safety. Because a combined low-temperature enzymatic hydrolysis-stepwise alcohol extraction-microfiltration purification process is used to prepare the Sophora flavescens extract, and natural menthol extract is added as a drug guide, the extraction rate and utilization efficiency of plant active ingredients are effectively improved, reducing the waste of plant resources. Furthermore, the preparation process is green and environmentally friendly, generating no harmful waste.

The application discloses an AaHDS gene of ananas comosus and application of the AaHDS gene in regulating aroma, and belongs to the field of genetic engineering of plants. The AaHDS gene of the ananas comosus is obtained by PCR amplification and cloning, the DNA sequence of the gene in the ananas comosus with aroma and the ananas comosus without aroma has obvious difference, and the expression amount of the gene is the highest in the inflorescence. The VIGS technology is used to silence the gene, the expression amount of the gene is reduced by 49.1 %, and the contents of alpha-pinene, beta-pinene and eucalyptol are significantly reduced. The AaHDS gene cloned by the application is beneficial to genetic improvement of plant aroma characteristics, and can be used for cultivating more new varieties of the ananas comosus with pleasant aroma.

The application discloses a gene of eudesmolsynthase AoTPS1 and an application of the gene and a coded protein, and provides a gene AoTPS1 for regulating biosynthesis of a monoterpenoid compound eudesmol, wherein a nucleotide sequence is shown as SEQ ID NO. 1, the total length of the sequence is 1785 bp, 594 amino acids are coded, the molecular weight is 69.03 kDa, and a coded amino acid sequence is shown as SEQ ID NO. 2. The eudesmolsynthase AoTPS1 protein has the function of catalyzing synthesis of eudesmol in vitro, meanwhile, overexpression of the eudesmolsynthase AoTPS1 gene by using a genetic transformation technology can significantly increase the content of eudesmol in monoterpenoid volatile oil compounds. Therefore, the AoTPS1 gene is a key gene for regulating synthesis of volatile oil of Eucommia ulmoides Oliv., and can significantly promote biosynthesis of eudesmol in monoterpenoid volatile oil and improve the medicinal value of volatile oil of Eucommia ulmoides Oliv.

The application provides a road efficient antifreeze and corrosion inhibitor snow-melting agent and a preparation method thereof. The snow-melting agent comprises 10-20% of an antifreeze agent, a corrosion inhibitor additive, and the balance of water. The corrosion inhibitor additive comprises 0.1-1% of sodium citrate, 0.1-1% of benzotriazole, 0.1-1% of sodium tripolyphosphate, 0.1-1% of sodium gluconate, 0.1-1% of tannic acid, 0.1-1% of polyvinylpyrrolidone and 0.1-1% of 2-hydroxyphosphonoacetic acid. The preparation method comprises antifreeze solution preparation, preparation of a mother liquor containing the antifreeze and corrosion inhibitor additive, and finally adding eucalyptol and triethanolamine oleate to the mother liquor containing the antifreeze and corrosion inhibitor additive to obtain the snow-melting agent. The application constructs a "precipitation film-adsorption film" composite protective layer, and simultaneously compounding organic corrosion inhibitors and inorganic corrosion inhibitors, so that the components are synergistically enhanced, and the corrosion resistance of the snow-melting agent is improved.

A pest control composition includes (i) from about 4 wt% to about 10 wt% of sodium lauryl sulfate; (ii) one or more C5 to C9 hydrotropic salt; (iii) from about 1 wt% to about 10 wt% of one or more active ingredients selected from the group consisting of corn mint oil, peppermint oil, spearmint oil, rosemary oil, thyme oil, citronella oil, clove oil, cedarwood oil, cinnamon oil, geranium oil, eugenol, 2-phenylethyl propionate, menthol, menthone, thymol, carvone, camphor, methyl salicylate, p-cymene, linalool, geraniol, cinnamyl acetate, cinnamic alcohol, cinnamaldehyde, citronellol, eucalyptol / 1,8- cineole, alpha-pinene, bornyl acetate, gamma-terpinene, and combinations thereof; (iv) from 1% to 5% by weight of a solvent, wherein the solvent is a C1-C4 alcohol, and (v) 60 wt% to about 95 wt % of water. The pest control composition exhibits a water peak in a H spectrum having a width encompassing 90% of the area of the entire water signal of about 50 Hz or more, as determined by the H NMR Method. A method of controlling one or more weeds by contacting the said weeds with the pest control composition.

According to the method for measuring the pesticide residues in the food through high-flux full-automatic emulsion microextraction, a full-automatic pipetting platform with a pipetting function is adopted for achieving multi-sample full-automatic pretreatment, and manual operation errors are avoided. Green and renewable eucalyptol is used as an extracting agent, so that the method has excellent environmental friendliness. Hydrophobic eudesmol and water are prepared into a high-concentration primary oil-in-water emulsion, and after the high-concentration primary oil-in-water emulsion is injected into a water-based sample, a low-concentration secondary oil-in-water emulsion is rapidly formed as an extraction system by utilizing the characteristic that the emulsion can be diluted, so that efficient extraction of pesticides is realized. And then injecting a sodium chloride solution into the system for demulsification, so that the extraction agent is rapidly separated without centrifugation. The method is successfully applied to food pesticide residue analysis, the reproducibility, the accuracy, the precision, the detection limit and the recovery rate all meet the analysis requirements, the cost is low, the operation continuity is high, the sample treatment efficiency is high, and a standardized solution can be provided for large-scale sample high-throughput pretreatment of a detection mechanism.

The invention relates to a plant composition for treating acute and chronic rhinitis and a preparation method thereof. The plant composition comprises the following raw material components in parts by weight: 7.5-20 parts of blumea oil; 3.5-6 parts of sesame oil; 0.8 to 2.5 parts of licoflavone A; 1.5-4 parts of a radix angelicae dahuricae extract; 2-6 parts of a cocklebur fruit extract; 3-9 parts of Roventura leaf essential oil; 8-15 parts of peppermint essential oil; and 12-24 parts of tea tree essential oil. In the formula of the composition disclosed by the invention, licoflavone A has the effects of resisting oxidation, resisting inflammation, regulating hormone and the like, and can be used for scavenging free radicals, effectively eliminating adverse effects of the free radicals on the nasal cavity and prolonging the acting effect and the shelf life. The folium artemisiae argyi contains volatile oil (such as eucalyptol, camphor and the like) and flavonoid compounds, and has the effects of inhibiting bacteria, relieving inflammation and alkalizing mucus; artemisia argyi can warm channels, dispel cold and relieve nasal obstruction, running nose and other symptoms caused by wind-cold or allergy.