205 results about "Bisabolol" patented technology

The invention discloses production of terpenoids and a strain, and belongs to the technical field of bioengineering. The serratia marcescens engineering bacteria for producing the semi-terpenoids or monoterpenoids are constructed, and can be used for producing linalool, isoprene, isopentenol, 1, 3, 4-triterpenes and 1, 3, 4-triterpenes. The composition is prepared from 1, 8-cineole, alpha-pinene, pinene, gamma-terpinene, geraniol, (+)-limonene, (-)-limonene, myrcene, beta-ocimene, sabinene, (-)-alpha-bisabolol, (-)-alpha-bisabolol, longifolene, wallenenes, beta-elemene, farnesene, patchouli alcohol, acyclic terpene and alpha-santalene. In a 30L fermentation tank, the yield of linalool produced by the serratia engineering bacteria is 40.72 g.L <-1 >.

The invention belongs to the technical field of personal hygiene products, and particularly relates to a nursing wet tissue which comprises a non-woven fabric body and formula production liquid, and the front end of the non-woven fabric body is provided with an opening; the formula production liquid comprises the following components: glycerol, propylene glycol, menthol, PEG-40 hydrogenated castor oil, benzalkonium chloride, phenoxyethanol, an aloe vera leaf extract, citronella oil, eucalyptus oil, bisabolol, G2833 (S) Baogoli LW-210060 and the balance of deionized water, wherein the total percentage of the components is 100%. According to the nursing wet tissue, in a sports scene, the nursing wet tissue can be fixed during use through the design of the opening and is prevented from sliding off; volatile oil components in menthol and peppermint oil in the formula production liquid can penetrate into the skin and act on pores, the pores can be effectively shrunk, the aperture of the pores is reduced, and therefore the chance that external dirt and grease enter the pores is reduced.

The present invention discloses a yeast engineering bacterium containing a (-)-α-bisabolol synthase mutant and its application. By designing (-)-α-bisabolol synthase, the present invention obtains a mutant with high expression level, co-expresses the mutant with ERG20, highly expresses the key rate-limiting enzymes in the metabolic pathway, deletes the promoter to reduce the side reaction pathway, and adopts a multi-copy strategy to improve the metabolic flux in the (-)-α-bisabolol biosynthesis pathway. The shake-flask fermentation yield of the yeast engineering bacterium constructed by the present invention is close to 70 mg / L, which is about 35 times higher than that of the starting strain, and has broad application prospects in the biological fermentation production of (-)-α-bisabolol.

The invention discloses a composition containing PDRN microspheres as well as a preparation method and application thereof, and relates to the technical field of repair. The composition containing the PDRN microspheres is prepared from the following components in parts by weight: 1 to 10 parts of the PDRN microspheres, 30 to 60 parts of sodium hyaluronate, 0.05 to 1 part of a cross-linking agent, 0.5 to 5 parts of bisabolol and 1 to 8 parts of trehalose, the molecular weight of the sodium hyaluronate is 300 kDa to 800 kDa. By adding the PDRN microspheres and selecting reasonable component compatibility, the stability is remarkably improved, and a synergistic effect is reflected in the aspect of repairing.

The invention relates to an itching relieving and soothing skin care lotion and a preparation method thereof. The skin care lotion is prepared from the following raw materials in parts by weight: 10-20 parts of grease, 1-3 parts of a nonionic emulsifier, 0.1-1 part of a skin feeling regulator, 0.5-2 parts of a first skin conditioner, 1-5 parts of a second skin conditioner, 0.1-1 part of an antioxidant, 1-2 parts of a humectant, 0.1-1 part of a pH regulator and 70-85 parts of water, the first skin conditioner contains a citrus peel extract and carboxymethyl chitosan, and the second skin conditioner contains hydroxyphenyl propionamide benzoic acid, stearyl glycyrrhetinate, menthol lactate, alpha-bisabolol and guaiazulene. The skin care lotion does not contain diphenhydramine hydrochloride and other substances with safety risks, is safe and mild, has remarkable itching relieving and soothing effects, and is safe and non-irritant to infants and children; during preparation, heating is little, and the activity of active substances can be reserved to the maximum extent so as to effectively ensure the itching relieving and relieving effects of the product.

The invention relates to a light loss repairing composition for improving skin resistance and application of the light loss repairing composition, and belongs to the technical field of cosmetics. The light loss repairing composition for improving the self resistance of the skin comprises the nannochloropsis oculata extract, the butterflybush flower extract and the bisabolol, all the components have a synergistic effect, ultraviolet light and blue light can be protected, and the light loss repairing composition has an anti-light aging effect and can be used for repairing the self resistance of the skin. And the mask has the effects of repairing skin barrier, relieving skin inflammation, improving redness, preventing hyperpigmentation, resisting aging, tightening skin, improving skin state and the like, and has the effect of improving self resistance of the skin.

The invention relates to the technical field of cosmetics, and particularly discloses a mild and stable A alcohol composition, an A alcohol cosmetic and a preparation method of the A alcohol composition and the A alcohol cosmetic. The mild and stable A alcohol composition is prepared from the following components in parts by weight: 0.1 to 0.5 part of A alcohol; 0.7 to 2.7 parts of a coating component; 0.3 to 0.9 part of a soothing component; the coating component is prepared from glycerol distearate, polyglycerol-10 pentastearate, behenyl alcohol, glyceryl stearate citrate and a composition of polyglycerol-6 stearate; the soothing component is prepared from hydroxyphenyl propionamide benzoic acid, a citrus fruit extract and bisabolol. According to the mild and stable A alcohol composition, the anti-aging, repairing and other effects of the A alcohol are guaranteed, and the irritation problem of the A alcohol is solved.

The invention relates to the technical field of skin care products, in particular to essence with repairing and moisturizing functions and a preparation method thereof.The essence is prepared from, by mass, 0.3%-0.7% of active caffeine, 5%-10% of humectants, 0.3%-0.6% of preservatives, 15%-25% of skin activating ingredients, 0.05%-0.5% of bisabolol, 0.2%-0.6% of stabilizers, 2%-4% of potassium azelaic diglycinate, 0.05%-0.3% of vitamin E and the balance water. And the balance of deionized water. The essence has repairing and moisturizing functions, is non-toxic, harmless and non-irritant to skin, and can relieve facial acnes and inhibit growth and reproduction of propionibacterium acnes.

The invention discloses candida tropicalis engineering bacteria for high yield of (-)-alpha-bisabolol and a construction method of the candida tropicalis engineering bacteria, and belongs to the technical field of microorganisms. According to the invention, chassis cell candida tropicalis DC04-WG04-2 is constructed, a gene Cat2 of catalase derived from saccharomyces cerevisiae and a gene ERG10 of 3-hydroxy-3-methylglutaryl coenzyme A reductase are expressed on the basis of the chassis cell candida tropicalis DC04-WG04-2, and a PEX15 motif is anchored on the surface of peroxisome for co-expression; the genes ADH1, GPD1 and GPD2 are further knocked out, so that the accumulation of ethanol is reduced, and the generation of glycerol is reduced. According to the method disclosed by the invention, the yield of the (-)-alpha-bisabolol of the recombinant candida tropicalis reaches 461.7 mg / L by optimizing fermentation conditions. The preparation method has the characteristics of low cost, high efficiency, simplicity in operation, wide prospect and the like.

The invention relates to the field of biological medicines and cosmetics, in particular to a composition which takes tetrapeptide and bisabolol as core components and has anti-inflammatory and anti-aging activity.

The invention provides a composition and cream with anti-inflammatory and skin barrier injury repairing effects as well as a preparation method and application of the composition and cream, and belongs to the technical field of skin injury repairing. The invention provides a composition with anti-inflammatory and skin barrier injury repairing effects. The composition is prepared from matrine, dipotassium glycyrrhizinate, bisabolol and asiaticoside according to the weight ratio of 1: 1: 1: 1. The composition provided by the invention can play a role through a multi-target mechanism, such as up-regulation of Invoucrin, and provides a more effective prevention and treatment scheme for skin barrier dysfunction related diseases and sensitive skin.

The present invention belongs to the field of cosmetics technology, specifically to a sunscreen and whitening composition, its preparation method, and its application. The present invention utilizes a combination of various functional ingredients, including ethylhexyl triazone, diethylamino hydroxybenzoyl hexyl benzoate, bis-ethylhexyloxyphenol methoxyphenyl triazine, niacinamide, glabridin, ascorbic acid derivatives, sodium hyaluronate, bisabolol, dipotassium glycyrrhizate, aloe vera juice, squalane, Chuanxiong extract, and Scutellaria baicalensis extract, to synergistically block UVA and UVB rays across the entire wavelength range and provide five-fold benefits: sunscreen, whitening, moisturizing, soothing, and repairing. This addresses the problem of many products on the market that offer only sunscreen without whitening and skincare benefits, providing effective skincare and protection.

The invention provides a yeast engineering bacterium, an establishment method thereof and application of the yeast engineering bacterium in synthesis of bisabolol. A series of exogenous genes are introduced into the yeast engineering strain through a gene recombination technology, so that the bisabolol production of the yeast engineering strain is effectively improved. The engineering bacterium for producing the bisabolol, which is obtained by the invention, provides a new way for industrial production of the bisabolol.

The invention discloses a method for producing terpenoids, and belongs to the technical field of bioengineering. The serratia marcescens engineering bacteria for producing the semi-terpenoids or monoterpenoids are constructed, and can be used for producing isoprene, isopentenol, 1, 3, 4-triterpenes, 1, 3, 4-triterpenes and the like. The composition is prepared from 1, 8-cineole, alpha-pinene, pinene, gamma-terpinene, geraniol, (+)-limonene, (-)-limonene, myrcene, beta-ocimene, sabinene, (-)-alpha-bisabolol, (-)-alpha-bisabolol, longifolene, wallenenes, beta-elemene, farnesene, patchouli alcohol, acyclic terpene and alpha-santalene. In a 30L fermentation tank, the yield of linalool produced by the serratia engineering bacteria is 13.49 g.L <-1 >.

The invention discloses cosmetic oil with whitening, soothing and anti-aging effects and a preparation method of the cosmetic oil. The plant essential oil is prepared from the following raw materials in parts by weight: 0.5 to 1.5 parts of sunflower seed oil, 0.01 to 0.05 part of lupinus albus seed extract, 0.0001 to 0.001 part of tocopherol, 0.01 to 0.05 part of rosemary leaf extract, 0.001 to 0.1 part of dimethyl methoxy benzodihydropyranol, 50 to 90 parts of caprylic / capric triglyceride, 0.01 to 0.2 part of ascorbyl tetraisopalmitate, 0.01 to 0.2 part of bisabolol, 5 to 20 parts of squalane, 2 to 8 parts of simmondsia chinensis seed oil, 5 to 15 parts of meadowfoam seed oil and 0.1 to 1 part of lavender oil. And 0.3-1 part of a centella asiatica extract. According to the cosmetic oil product provided by the invention, by optimizing the use of substances, the composition has triple effects of whitening, relieving and resisting aging, can meet multiple skin care requirements of consumers at the same time, and is wide in market application range.

The invention belongs to the technical field of cosmetics, and relates to a multichannel multi-target accurate delivery anti-allergy soothing nano-composite and a preparation method and application thereof, glycyrrhizic acid, bisabolol, 4-tert-butyl cyclohexanol and hydroxyphenyl propionamide benzoic acid are selected as anti-allergy soothing functional components. Comprising the following raw materials in percentage by mass: 0.1-5wt% of glycyrrhetinic acid; 0.1 to 10 weight percent of bisabolol; 0.001 wt% to 1 wt% of 4-tert-butyl cyclohexanol; 0.01 to 1 wt% of hydroxyphenyl propionamide benzoic acid; 10 to 50 wt% of an emulsifier; 1 to 20 wt% of a liquid lipid; 1 to 10 wt% of a co-emulsifier; 10 to 30 wt% of a polyol; and the balance of water. The sum of the mass percentages of the components is 100%. According to different passages of different active ingredients, the four active ingredients are simultaneously loaded in the same composition, so that multi-passage and multi-target accurate delivery can be realized, the skin can be timely and efficiently relieved from the source, the uncomfortable symptoms of the skin can be solved, and the immunity of the skin can be improved.

The invention discloses a wet tissue liquid for improving hemorrhoid symptoms, a wet tissue, a production method and application, the wet tissue liquid comprises asiaticoside, a sophora flower charcoal extract, bisabolol, a honeysuckle flower extract, a rosemary extract, ceramide NP, D-panthenol, potassium cocoyl glycinate, citric acid, sodium citrate and purified water, and the wet tissue comprises spunlace non-woven fabric. The wet tissue liquid is loaded on a non-woven fabric, the production process of the wet tissue liquid comprises a pretreatment stage, a preparation stage and a filtering stage, and the produced wet tissue liquid is applied to hygienic products for improving hemorrhoid symptoms. The sophora flower charcoal extract is used for the haemorrhoids wet tissue liquid to achieve the effects of stopping bleeding, cleaning and mildly easing pain; double natural extracts are compounded to replace preservatives, traditional single symptom relief is upgraded to symptom treatment, mucous membrane repair and barrier protection, disease deterioration and recurrence risks are reduced, and the composition is free of chemical preservatives, free of irritant surface activity and suitable for being used by people with hemorrhoid symptoms.

The invention relates to the fields of genetic engineering and microbial fermentation, and discloses a recombinant strain for highly producing terpenoids as well as a construction method and application of the recombinant strain. The recombinant strain is obtained by genetic engineering modification of an original strain, compared with the original strain, the recombinant strain enhances the synthetic route of terpenoids, and the activity of pyruvate kinase, pyruvate dehydrogenase complex, glucose-6-phosphate dehydrogenase and key enzymes for synthesis of terpenoids is enhanced by using a CRISPR activation system; wherein the sgRNA expression promoters of the pyruvate kinase and the pyruvate dehydrogenase complex are respectively oleic acid induction type promoters, and the sgRNA expression promoters of the glucose-6-phosphate dehydrogenase and the terpene compound synthesis key enzyme are respectively copper ion induction type promoters. The recombinant strain can dynamically regulate and control an editing system of the terpenoids, precisely regulate and control the synthetic pathway flux of the terpenoids, and effectively improve the yield of the terpenoids (such as sclareol and bisabolol).

The invention discloses an NMN and bisabolol supramolecule as well as a preparation method and application of the NMN and bisabolol supramolecule. The method comprises the following steps: mixing NMN, choline chloride and glucosamine to form a transparent homogeneous liquid under the protection of nitrogen; and adding (-) alpha-bisabolol into the transparent homogeneous liquid, stirring and mixing, and carrying out vacuum degassing treatment to obtain the NMN and (-) alpha-bisabolol supramolecules. The obtained supramolecule solves the problem that the NMN and the (-) alpha-bisabolol are immiscible with each other, and meanwhile, the permeation resistance is reduced, and the transdermal absorption is promoted, so that the NMN and the (-) alpha-bisabolol cooperate with the skin to resist light aging. The invention further provides a method for preparing the supramolecules into the lipidosome through a lipidosome wrapping technology, the supramolecules achieve supramolecular smearing type skin care by means of the lipidosome wrapping technology, operation is easy and convenient, and the effect is fast. The method is suitable for preparing the skin anti-photoaging preparation.

The invention discloses a biomolecular film composition, a skin external preparation as well as a preparation method and application of the biomolecular film composition and the skin external preparation. The composition comprises the following components: 5%-30% of bisabolol; 2%-20% of oryzanol; 0-60% of grease; 0.3%-6% of ethyl cellulose and / or 5%-40% of a rape / tung oil copolymer; 0.5% to 8% of C20-40 acid; 0.1%-1% of a neutralizer; 0.025% to 0.225% of silk fibroin; 0.05% to 0.45% of glucomannan; and 0.1%-1.6% of a preservative. Water-soluble active molecules and oil-soluble active molecules are combined together through hydrophobic chains and hydrophilic chains in fibroin, the composition is prepared through high-pressure homogenization, and the composition has the effects of oxidation resistance, UV damage repair, UV light protection and inflammation resistance and can be adsorbed on the skin surface to form a film; the composition can be used together with a sun-screening agent, so that the sun-screening efficiency and stability of the sun-screening agent are improved, and relatively good water-resistant and sweat-resistant performance is provided.

The invention discloses a recombinant bacterium capable of increasing the yield of alpha-bisabolol as well as a preparation method and application of the recombinant bacterium, and belongs to the technical field of microorganisms. The invention aims to improve the yield of alpha-bisabolol and enhance the tolerance of a host to an organic solvent. The invention provides a recombinant bacterium for improving the yield of alpha-bisabolol. Escherichia coli is used as a starting strain; the method comprises the following steps of: overexpressing an acetyl CoA acyltransferase / HMG-CoA reductase mvaE gene, an HMG-CoA synthetase mvaS gene, a 2-methyl citrate dehydratase prpD gene, a mevalonate kinase ERG12 gene, a mevalonate 5-phosphate kinase ERG8 gene, a mevalonate 5-diphosphate decarboxylase ERG19 gene and an isopentenyl diphosphate isomerase idi gene, so as to obtain a recombinant vector; the gene is obtained from an alpha-bisabolol synthase gene of artichoke, a farnesyl diphosphate synthase ispA gene and an alpha-bisabolol synthase CcBOS gene of artichoke. The industrial process of synthesizing alpha-bisabolol by a biological method is promoted.

The invention discloses a traditional Chinese medicine combination effective part capable of improving diabetic peripheral neuropathy. The traditional Chinese medicine combination effective part is prepared from a volatile oil effective part, a water-soluble effective part and an alcohol-soluble effective part, the effective part of the volatile oil comprises alpha-ocimene, alpha-santalene, bisabolol, beta-bisabolol and nerolidol; the water-soluble effective part comprises salvianolic acid A, salvianolic acid B and tanshinol; the alcohol-soluble effective part is prepared from Z-ligustilide, alpha-masticinic acid, beta-masticinic acid, tanshinone IIA, and 2-methoxy-5-acetyl-furangermacane-1 (10)-ene-6-ketone, and the alcohol-soluble effective part is prepared from the following raw materials in parts by weight: 2-methoxy-5-acetyl-furangermacane-1 (10)-ene-6-ketone. The traditional Chinese medicine composition effective part provided by the invention can regulate blood sugar, improve the conduction speed of sciatic nerves, repair damaged tissues, inhibit oxidative stress reaction, resist inflammation and relieve pain, so that the diabetic peripheral neuropathy is improved, the curative effect is reliable, the safety is good, the adverse reaction is low, and the traditional Chinese medicine composition effective part can be used for preparing a medicinal preparation for improving the diabetic peripheral neuropathy.

The invention discloses supramolecular liquid crystal cream and a preparation method thereof, and relates to the technical field of cosmetic preparation. Comprising 0.3%-2% of supramolecular 10-hydroxydecanoic acid-alpha-bisabolol, 1.5%-5% of an emulsifier, 0.5%-3% of behenyl alcohol, 6.8%-23% of an emollient, 1.5%-6% of an emulsion stabilizer, 0.95%-2.85% of a thickener, 5%-14% of a humectant, 0.6%-1.8% of a preservative and a proper amount of water. Wherein the emulsion stabilizer comprises cetostearyl alcohol, and the mass ratio of the cetostearyl alcohol to the behenyl alcohol is (0.5-2): (0.5-3); the thickening agent comprises at least one of xanthan gum, microcrystalline cellulose / cellulose gum and bentonite. The specific thickening agent and the long-chain fatty alcohol emulsion stabilizer are added into the supramolecular system, so that ordered arrangement of liquid crystals in the supramolecular system is remarkably promoted, the mechanical strength of the lamellar liquid crystals is improved, and the stability of the supramolecular liquid crystal system is further improved.

The invention discloses a mild antibacterial anti-dandruff composition and a preparation method thereof. The composition comprises an acrylate copolymer, maltooligosaccharide and bisabolol, the mass ratio of the acrylate copolymer to the maltooligosaccharide to the bisabolol is (0.01 to 0.3) to (0.1 to 0.8) to (0.05 to 0.5); the preparation method comprises the following steps: sequentially adding the acrylate copolymer, the maltooligosaccharide and the bisabolol into water according to the mass ratio, and uniformly stirring until the materials are dissolved. The acrylate copolymer, the maltooligosaccharide and the bisabolol are blended in proportion, the maltooligosaccharide becomes a carbon source of microorganisms, malassezia is efficiently inhibited, staphylococcus epidermidis is not excessively inhibited, and meanwhile, the skin mildness and moisture retention are achieved; the bisabolol is used as a plasticizer, so that the composition of the acrylate copolymer and the maltooligosaccharide forms a uniform and tough film, the effect on malassezia and staphylococcus epidermidis is enhanced, and the anti-dandruff effect is improved.

Retinol-based composition. The present invention relates to a composition, particularly a cosmetic one, especially for makeup and / or the treatment of keratinous materials, comprising at least one retinoid, in particular retinol; bisabolol; 4-t-butylcyclohexanol; niacinamide; and D-panthenol. Figure for the abstract: None

The invention discloses a face-protecting and skin-nourishing firming oil. Comprising the following components in parts by weight: 50 to 55 parts of caprylic / capric triglyceride, 25 to 35 parts of hydrogenated polyisobutene, 0.8 to 1.2 parts of tocopheryl acetate, 8 to 12 parts of sesame seed oil, 0.8 to 1.2 parts of caprylic / capric triglyceride, 0.8 to 1.2 parts of alkanet extract, 0.8 to 1.2 parts of oat kernel oil, 0.1 to 0.3 part of bisabolol, 0.1 to 0.3 part of rosemary leaf oil, 0.4 to 0.6 part of cardiospermum halicacabum flower / leaf / vine extract and 0.4 to 0.6 part of ginseng root extract. 0.4 to 0.6 part of camellia seed extract and 0.4 to 0.6 part of octyldodecanol. The compact oil has the advantages that the compact oil does not contain harmful ingredients such as heavy metals, and potential threats to health are avoided after the compact oil is used. The effect is lasting, the problems of skin laxity and the like are fundamentally solved, and the long-term tightening effect is gradually achieved.

The invention belongs to the technical field of cosmetics, and provides a moisturizing, whitening and cleaning type white mud mask and a preparation method thereof.The white mud mask is prepared from, by weight, 35-45 parts of purified water, 15-20 parts of a moisturizing agent, 15-18 parts of Amazon white mud, 6-9 parts of kaolin, 6-9 parts of bentonite, 6-13 parts of an emollient, 4-7 parts of a skin whitening agent and 2-4 parts of a stabilizer. The composition is prepared from the following raw materials in parts by weight: 1 to 3 parts of lecithin, 0.1 to 0.8 part of xanthan gum, 0.1 to 0.5 part of allantoin, 0.1 to 0.3 part of phenoxyethanol, 0.1 to 0.3 part of ethylhexylglycerin and 0.1 to 0.3 part of bisabolol. Wherein the humectant is prepared from a moisture absorbent, a moisturizing active ingredient and a water locking agent. The white mud mask disclosed by the invention is safe in components and comfortable in body feeling, not only has an efficient skin cleaning effect, but also has the effects of whitening, moisturizing and controlling oil, can improve the activity of skin cells and accelerate the metabolism of the skin cells at the same time, achieves the multifunctional composite skin nourishing effect of a single product, reduces the irritation, and can be suitable for various types of skins.

The invention relates to the technical field of biology, and particularly discloses pichia pastoris as well as a construction method and application thereof. According to the pichia pastoris disclosed by the invention, beta-glucan is knocked out to synthesize a related gene gas1. By deleting the beta-glucan coding gene gas1 gene of the pichia pastoris cell wall, the cell size is reduced, the transmission distance from the cell surface to the cell nucleus is reduced, oxygen transmission and product secretion during high-density culture are improved, and the fermentation production efficiency is improved. In addition, the pichia pastoris constructed by the invention enhances the synthesis of the intracellular product bisabolol, and also can enhance the secretion ability of the intracellular product bisabolol. By reducing the cell size, reducing the carbon flow flowing to the cell wall polysaccharide synthesis and increasing the carbon source flowing to the target product synthesis, the application has great significance in industrial production.

The application provides a method for separating and purifying bisabolol from fermented residue of bisabolol, which comprises the following steps: taking the fermented residue of bisabolol, stirring with an organic solvent, filtering, taking the filtrate to decolorize, and distilling the decolorized liquid to obtain the bisabolol. The preparation method can successfully obtain high-purity bisabolol, and has the advantages of simple operation, low cost and low solvent toxicity.

The present application describes compositions comprising 5-MeO-DMT, one or more diluents, and optionally a cannabinoid compound for inhalation through vaporization. In certain embodiments, the compositions can be utilized as a treatment of trauma-related disorder or stressor-related disorder, such as post-traumatic stress disorder (PTSD), acute stress disorder (ASD), reactive attachment disorder (RAD), and disinhibited social engagement disorder (DSED). In particular embodiments, the composition comprises about 15-45% 5-MeO-DMT and 15-35% CBD dissolved in triethyl citrate or alpha-bisabolol, which has been observed herein to effectively remedy patients' anxiety and stress.