61 results about "Bisabolol" patented technology

The invention relates to a light loss repairing composition for improving skin resistance and application of the light loss repairing composition, and belongs to the technical field of cosmetics. The light loss repairing composition for improving the self resistance of the skin comprises the nannochloropsis oculata extract, the butterflybush flower extract and the bisabolol, all the components have a synergistic effect, ultraviolet light and blue light can be protected, and the light loss repairing composition has an anti-light aging effect and can be used for repairing the self resistance of the skin. And the mask has the effects of repairing skin barrier, relieving skin inflammation, improving redness, preventing hyperpigmentation, resisting aging, tightening skin, improving skin state and the like, and has the effect of improving self resistance of the skin.

The invention discloses a recombinant bacterium capable of increasing the yield of alpha-bisabolol as well as a preparation method and application of the recombinant bacterium, and belongs to the technical field of microorganisms. The invention aims to improve the yield of alpha-bisabolol and enhance the tolerance of a host to an organic solvent. The invention provides a recombinant bacterium for improving the yield of alpha-bisabolol. Escherichia coli is used as a starting strain; the method comprises the following steps of: overexpressing an acetyl CoA acyltransferase / HMG-CoA reductase mvaE gene, an HMG-CoA synthetase mvaS gene, a 2-methyl citrate dehydratase prpD gene, a mevalonate kinase ERG12 gene, a mevalonate 5-phosphate kinase ERG8 gene, a mevalonate 5-diphosphate decarboxylase ERG19 gene and an isopentenyl diphosphate isomerase idi gene, so as to obtain a recombinant vector; the gene is obtained from an alpha-bisabolol synthase gene of artichoke, a farnesyl diphosphate synthase ispA gene and an alpha-bisabolol synthase CcBOS gene of artichoke. The industrial process of synthesizing alpha-bisabolol by a biological method is promoted.

Retinol-based composition. The present invention relates to a composition, particularly a cosmetic one, especially for makeup and / or the treatment of keratinous materials, comprising at least one retinoid, in particular retinol; bisabolol; 4-t-butylcyclohexanol; niacinamide; and D-panthenol. Figure for the abstract: None

The application provides a method for separating and purifying bisabolol from fermented residue of bisabolol, which comprises the following steps: taking the fermented residue of bisabolol, stirring with an organic solvent, filtering, taking the filtrate to decolorize, and distilling the decolorized liquid to obtain the bisabolol. The preparation method can successfully obtain high-purity bisabolol, and has the advantages of simple operation, low cost and low solvent toxicity.

The invention relates to the field of scalp water, in particular to scalp water with moisturizing, soothing and tightening effects as well as a preparation method and application of the scalp water. According to the scalp lotion, the active ingredients such as the perigord truffle extract, the mistletoe extract, the artemisia capillaris extract and the denseflower rodendranthus herb extract are selected, and the raw materials such as the humectant, the tripeptide-1, the witch hazel extract, the dipotassium glycyrrhizinate and the bisabolol with the moisturizing, relieving and tightening effects are selected, so that the scalp lotion has the moisturizing, relieving and tightening properties; meanwhile, selection of the raw materials is optimized, the process and matching of the extracts are improved, and the performance of tightening the scalp, relieving the scalp and the like is further improved.

The present application provides a kind of microalgae source glycerol glucoside preparation and its preparation method and application, belong to medical technical field.The crude extract solution is obtained by low-osmotic extraction liquid extraction to salt stress algal mud, impurity is removed by filtration, and phycocyanin concentrated solution and glycerol glucoside containing permeate are obtained by membrane filtration separation, glycerol glucoside containing permeate is concentrated, bleaching and desalting, drying, and microalgae source glycerol glucoside is prepared, is mixed uniformly with gypenoside and bisabolol, and the mixture is prepared, after being embedded with oleic acid modified cholesterol and phospholipid to prepare modified liposome, mixed with chitosan solution and reacted, centrifuged, and the supernatant is discarded, and the solid is washed and dried to prepare microalgae source glycerol glucoside preparation.The present application realizes the technical effects of microalgae resource green low-carbon high-value utilization, product efficient purification, multi-target point synergistic anti-inflammatory and high transdermal absorption retention, and provides a kind of safe and effective, long-term use natural source new choice for treating atopic dermatitis externally.

This invention discloses the application of α-bisabolol in the preparation of a quorum sensing quencher for Serratia liquefaction. It belongs to the field of pharmaceutical technology. The purpose of this invention is to provide an application in the preparation of a quencher for inhibiting the quorum sensing system of Serratia liquefaction, thereby reducing the toxicity of pathogenic bacteria without inhibiting their growth. This invention provides an application of bisabolol in the preparation of a quencher for inhibiting the quorum sensing system of Serratia liquefaction. It offers a novel solution for developing efficient and safe food preservatives.

The application relates to the technical field of enzyme engineering, in particular to a (-)-alpha-bisabolol synthase mutant and application thereof. On the basis of a wild-type (-)-alpha-bisabolol synthase (SEQ ID No: 1), three types of (-)-alpha-bisabolol synthase mutants are constructed through substitution, deletion and addition mutation modes, and the (-)-alpha-bisabolol synthase activity of homologous mutants with different consistency obtained through the above different mutation modes is investigated, and the yield ratio relative to the wild type when used for fermentative production of (-)-alpha-bisabolol is investigated. It is proved that the above mutants all achieve the same or higher (-)-alpha-bisabolol yield as the wild-type (-)-alpha-bisabolol synthase. It is proved that the above mutation modes and the obtained mutants and the recombinant cells for biosynthesizing the mutants can be used for batch production and popularization of (-)-alpha-bisabolol, thereby helping the development of many downstream industries such as beauty and medicine.

This application relates to the field of biotechnology, specifically disclosing a *Pichia pastoris* yeast, its construction method, and its applications. This application involves knocking out the *gas1* gene, which is related to β-glucan synthesis, in *Pichia pastoris*. By deleting the *gas1* gene, which encodes β-glucan in the cell wall of *Pichia pastoris*, this application reduces cell size, decreases the transfer distance from the cell surface to the nucleus, improves oxygen transfer and product secretion during high-density culture, and enhances fermentation efficiency. Furthermore, the *Pichia pastoris* yeast constructed using this application enhances the synthesis of the intracellular product bisabolol and also enhances its secretion capacity. This application, by reducing cell size and decreasing the carbon flow to cell wall polysaccharide synthesis while increasing the carbon source flow to target product synthesis, has significant implications for industrial production.

The invention relates to the technical field of cosmetics, in particular to a blue copper peptide-containing cosmetic as well as a preparation method and application thereof. Specifically, the transdermal composition containing the blue copper peptide comprises an active component tripeptide-1 copper and a transdermal synergistic component composed of methyl glucitol polyether-20 and hydrogenated lecithin according to the mass ratio of (5-15): 1, and the transdermal absorption rate and the storage stability of the blue copper peptide can be synergistically improved by the system; and / or the blue copper peptide synergistic composition comprises tripeptide-1 copper and a second active component composed of glycyrrhetinic acid and bisabolol, the mass ratio of the tripeptide-1 copper to the second active component is 1: (0.5-5), and the composition can generate a synergistic anti-inflammatory repair effect. According to the cosmetic disclosed by the invention, the technical bottlenecks that the blue copper peptide is poor in stability and difficult in transdermal penetration in cosmetics and cannot fully exert the effect in an inflammatory environment are effectively solved through independent or combined application of the composition.

The invention relates to the field of cosmetics, in particular to cleansing oil and a preparation method of the cleansing oil. Comprising the following components in percentage by weight: 15%-25% of cetyl ethyl hexanoate, 2%-5% of diisostearyl malate, 8%-12% of ethylhexyl palmitate, 15%-25% of isohexadecane, 10%-20% of rice chaff oil, 0.1%-1% of simmondsia chinensis seed oil, 0.1%-1% of meadowfoam seed oil, 0.1%-1% of silybum marianum seed oil, 0.1%-1% of macadamia nut seed oil, 2%-5% of PEG-7 glyceryl cocoate and 10%-15% of polyglycerol-10 dioleate. The invention discloses cleansing oil and a preparation method thereof, and the cleansing oil comprises the following components in percentage by weight: 20-30% of cleansing oil, 3-6% of polyglycerol-dioctanoate, 0.01-0.1% of ascorbyl tetraisopalmitate, 0.05-0.3% of tocopheryl acetate and 0.1-0.3% of bisabolol. The cleansing oil and the preparation method thereof provided by the invention solve the problems that the cleaning efficiency and the mildness of the existing cleansing oil are contradictory, and the existing cleansing oil lacks antioxidant and repairing effects.

The invention provides a method for recycling a heavy phase generated in a process of producing (-)-alpha-bisabolol by a biological method, and belongs to the technical field of biosynthesis. The method comprises the following steps: (1) heavy phase pretreatment: adding a heavy phase containing (-)-alpha-bisabolol into a solvent, and then decolorizing to obtain a decolorized solution; (2) distillation: distilling the decolorized solution obtained in the step (1) to obtain a (-)-alpha-bisabolol crude product; and (3) molecular distillation: carrying out molecular distillation on the crude product obtained in the step (2) to obtain the (-)-alpha-bisabolol. According to the method disclosed by the invention, a high-purity (-)-alpha-bisabolol product is obtained from a heavy phase generated in the process of producing (-)-alpha-bisabolol by a biological method by adopting a simple process, so that the yield of (-)-alpha-bisabolol is improved, and meanwhile, the problem of waste treatment in the process of producing (-)-alpha-bisabolol by the biological method is solved; good application prospects are realized.

The invention discloses a high-concentration azelaic acid acne-removing soothing emulsion, and belongs to the technical field of medicines and skin care products. The method successfully breaks through the technical bottleneck that the solubility of azelaic acid in a conventional water-oil system is extremely low (generally 1t; 1%). According to the invention, 13-19% high-mass-fraction stable loading of azelaic acid can be realized, the system is still kept in a uniform and transparent liquid state at room temperature and after high and low temperature circulation, no crystal is separated out, and the physical friction stimulation of azelaic acid solid crystal particles to the skin in the traditional formula is eliminated. Meanwhile, the bisabolol, capryloyl glycine and other components contained in the system have an instant soothing effect, chemical irritation of azelaic acid can be reduced, and skin tolerance and use comfort of the product are remarkably improved.

The invention relates to the technical field of protease mutation, and discloses a bisabolol synthase mutant with high catalytic activity and application of the bisabolol synthase mutant. According to the method, alpha-bisabolol synthase derived from compositae herbaceous plant globe artichoke is taken as wild enzyme, mutants are virtually screened by applying a protein language model SaProt, a deep learning model Catapro and a protein stability prediction tool Dynaamt, and the effect of producing bisabolol is verified through experiments; according to the present invention, the mutants obtained by mutation of 11 specific amino acid sites such as D125N, F159Y, F159K, N346D, T372S, Y432F, N346S, D184E, N157E, E374A and T258S are obtained through the mutation of the above 11 specific amino acid sites; wherein through 96-hour shake flask fermentation and gas chromatography detection, the bisabolol yields of the obtained single-point mutation T258S and double-point mutation T258S / F159K are respectively increased by 72.6% and 90.2% compared with the wild type yield; the Kcat / Km value of the two-point mutation T258S / F159K is 4.57 times that of a wild type.

The invention discloses a composition for repairing a tough skin barrier of sensitive skin and a preparation method and application thereof, the composition for repairing the tough skin barrier of the sensitive skin comprises bisabolol, a ginger root extract and ceramide, and the mass ratio of the bisabolol to the ginger root extract to the ceramide is (0.001-5): (0.0001-1): (0.001-5). The bisabolol has anti-inflammatory and soothing effects; the ginger root extract has natural oxidation resistance and can help relieve damage of the external environment to the skin; ceramide can effectively supplement skin lipid and repair a damaged barrier structure. Under the synergistic effect of the bisabolol, the ginger root extract and the ceramide, uncomfortable symptoms such as redness and pruritus of sensitive skin can be quickly relieved, meanwhile, the skin barrier function is fundamentally enhanced, the skin tolerance and the water retention capacity are improved, and the composition can be applied to cosmetics as a composition for repairing the sensitive skin and strengthening the skin barrier.

The invention relates to bisabolol for use as a miticide agent, the use of bisabolol as a miticide, a method for reducing or preventing an infestation of an animal by a mite, comprising exposing the mite to bisabolol, a composition adapted for use as a miticide agent comprising bisabolol, a strip adapted for use in apiculture comprising bisabolol and to a hive comprising bisabolol.

This invention belongs to the technical field of fermentation-derived active ingredients, skin care active compositions, and topical formulations, specifically relating to a grape seed compound active composition with antioxidant effects, its preparation method, and its application. The composition uses grape seed fermentation filtrate as the main active base, and is synergistically compounded with Bifida ferment lysate and α-bisabolol. By compounding grape seed fermentation filtrate as the main component and Bifida ferment lysate and α-bisabolol as synergistic active components, a topical active composition that combines antioxidant care, gentleness, and dosage form suitability can be obtained. The composition can be formulated into topical formulations such as serums, essences, gels, sprays, lotions, facial masks, wet compresses, or lyophilized powder reconstituted solutions, and is suitable for the development of antioxidant care products.

The invention discloses suspension essence oil containing microencapsulated volcanic mud, which is prepared from the following components in percentage by mass: 3 to 8 percent of microencapsulated volcanic mud, 85 to 95 percent of suspension essence oil matrix and 1 to 5 percent of functional additive, core material components of the microencapsulated volcanic mud are volcanic mud, ceramide NP, tetra-hexyldecanol ascorbate or tocopheryl acetate, and core material components of the microencapsulated volcanic mud are nano silicon dioxide or nano silicon dioxide or nano silicon dioxide or nano silicon dioxide or nano silicon dioxide or nano silicon dioxide or nano silicon dioxide or nano silicon dioxide or nano silicon dioxide or nano silicon dioxide or nano silicon dioxide or nano silicon dioxide or nano silicon dioxide. The component of the wall material is porous silicon dioxide; the suspended essence oil substrate is prepared from the following components: simmondsia chinensis seed oil, squalane, fumed silica and vinyl polydimethylsiloxane; and the functional auxiliary agent comprises the following components: bisabolol, a chelating agent and a preservative. The suspension essence oil provided by the invention integrates the adsorbability of volcanic mud, the barrier repair capacity of ceramide NP and the antioxidant brightening characteristic of VC derivatives through the synergism of microencapsulation and a suspension stable system, realizes the multiple synergistic effects of cleaning, oil control, antioxidant and soothing, and meanwhile, the microcapsule controls the release speed of components, so that the release speed of the components is controlled, and the release effect of the components is improved. Direct contact of volcanic mud to skin is reduced, and the skin feeling effect is improved.

The invention discloses a (-)-alpha-bisabolol synthase mutant and application thereof, and belongs to the technical field of enzyme engineering and microbial engineering. According to the invention, (-)-alpha-bisabolol synthase BOS from cynara scolymus is taken as an object, based on sequence conservative analysis and semi-rational design, a series of BOS mutants obtained by the invention are obviously improved in the aspect of FPP substrate conversion efficiency, and the optimal (-)-alpha-bisabolol synthase BOSG119W-H151Y-F282Y-H302Q has the advantages that the conversion efficiency of the FPP substrate is obviously improved, and the optimal (-)-alpha-bisabolol synthase BOSG119W-H151Y-F282Y-H302Q is obviously improved; the yield of the generated (-)-alpha-bisabolol is 16.7 times that of a wild type, and the yield exceeds 2g / L. The (-)-alpha-bisabolol synthase mutant enhances the performance of microbial synthesis of (-)-alpha-bisabolol, and provides an effective technical route for green production of industrial high-purity (-)-alpha-bisabolol.

The utility model relates to the technical field of bisabolol production, in particular to a bisabolol fermentation mushroom dreg separating and filtering structure which comprises a filtering barrel, a liquid outlet pipe is mounted at the bottom of one end of the filtering barrel, and a filtering cylinder is arranged in the filtering barrel; the top end of the separation barrel is sleeved with the sealing cover in a threaded mode, the sealing cover is convenient to disassemble and assemble, the separation barrel can be limited by rotationally installing a limiting ring in a limiting groove, the separation barrel can be driven to rotate on the barrel cover through the transmission effect of a motor, a driven gear and a driving gear, and the separation barrel can be separated through a filter screen on the side wall of the bottom of the separation barrel. The barrel cover can be conveniently disassembled and assembled and the separation barrel can be conveniently taken out through connecting bolts on the surface of the barrel cover when a filter screen is seriously blocked after long-time use, and the filter cartridge can be conveniently taken out by clamping and inserting a positioning ring into an annular groove; and therefore, the filter screen and the filter cartridge can be regularly cleaned conveniently, and the separation and filtration effect is prevented from being affected.

The invention discloses a novel oil-soluble micelle preparation. The component A comprises lecithin, soya bean lecithin, egg yolk lecithin, 1-palmitoyl-2-oleoyl lecithin, phosphatidylserine, phosphatidylinositol, phosphatidyl glycerol, cardiolipin, cephalin and dipalmitoyl phosphatidylcholine, and the component B comprises lecithin, soya bean lecithin, egg yolk lecithin, 1-palmitoyl-2-oleoyl lecithin, phosphatidylserine, phosphatidylinositol, phosphatidyl glycerol, phosphatidylcholine, cephalin and dipalmitoyl phosphatidylcholine; one or more of dipalmitoyl phosphatidyl ethanolamine and dipalmitoyl phosphatidyl ethanolamine; the component B comprises a component B1 and a component B2, and the component B1 comprises one or more of phytosterol, cholesterol, ergosterol, protopanoxadiol, protopanaxatriol, ganoderic acid, phytol, isophytol, retinol, andrographolide, paclitaxel, artemisinin and bisabolol; and the component B2 is prepared from one or more of 1, 2-hexanediol, ethylhexylglycerin, cyclohexyl glycerin, absolute ethyl alcohol and isosorbide dimethyl ether. The key point of the invention is to provide a low-cost formula and a low-cost preparation method for preparing the oil-soluble micelle preparation.

The invention provides an efficient long-acting mosquito-repelling moisturizing soothing emulsion and a preparation method thereof. The efficient long-acting mosquito-repelling moisturizing soothing emulsion comprises 6.0-10.0% of butyl acetamido ethyl propionate serving as a mosquito-repelling active substance, and the balance of water. The pH buffer system is composed of sodium citrate and citric acid and is used for stabilizing the pH value of the product in an optimal range of 6.0 to 6.5 so as to prevent hydrolysis of active matters; the synergistic soothing protection system comprises at least two of bisabolol, a radix sophorae flavescentis extract and allantoin and is used for neutralizing potential skin irritation. On the premise of conforming to cosmetic laws and regulations, the repellent rate of not less than 90% and the effective protection time of more than 6 hours are realized, meanwhile, tests show that the stimulation rate to sensitive skin is 0%, and the composition has excellent chemical stability and skin care feeling.

This invention belongs to the technical field of functional personal care products, and specifically relates to a highly efficient and stable natural sulfur hot spring bath concentrate formula and its preparation process. The bath concentrate formula, by mass percentage, comprises the following components: 35.0-65.0% sulfur hot spring active concentrate, 0.001-0.01% sodium selenite, 0.1-1.0% sodium thiosulfate, 0.05-0.2% disodium EDTA, 0.5-3.0% cationic liposomes, 0.2-0.8% carrageenan, 0.5-3.0% calcium source, 0.3-2.0% magnesium source, 0.1-0.5% bisabolol, 0.1-0.5% dipotassium glycyrrhizate, 0.2-1.5% citrate-sodium citrate buffer pair, 3.0-8.0% polyol, 0.1-0.3% β-cyclodextrin-encapsulated fragrance, and deionized water to 100%. A liquid bath concentrate was obtained using natural sulfur hot spring water as the water source, which fully retains its active sulfide spectrum and characteristic mineral ions, and can be stored for a long time at normal temperature and pressure. It has the advantages of high stability, high polysulfide content, slow release, and no irritation.

The invention belongs to the technical field of cosmetics, and particularly relates to a tough anti-breaking composition and a preparation method thereof. The tough anti-breaking composition comprises water, a surfactant, a conditioner, a cationic polymer, microcrystalline cellulose and a tough repairing component, the strengthening and repairing component is prepared from hydrolyzed keratin, rice sprout yeast, bisabolol, shea butter and D-panthenol. According to the composition disclosed by the invention, the hair strengthening effect of the composition is improved through the synergistic effect of the components by utilizing the adsorption, deposition and film forming effects of the cationic polymer and the microcrystalline cellulose and the permeation and repair effects of the hydrolyzed keratin, the rice sprout yeast, the bisabolol, the shea butter and the D-panthenol.

The invention provides a composition with a whitening effect as well as a preparation method and application of the composition. The composition is prepared from ascorbic acid glucoside ionic liquid, a nicotinamide compound, a bisabolol inclusion compound and milk active peptide, the weight ratio of the ascorbic acid glucoside ionic liquid to the nicotinamide compound to the bisabolol clathrate compound to the milk active peptide is (3-8): (3-6): (0.3-1): (1-5); according to the preparation method, the ascorbic acid glucoside is combined with specific cations, so that the ascorbic acid glucoside derivative ionic liquid can be constructed, the chemical stability and skin permeability of the ascorbic acid glucoside can be remarkably improved, and the ascorbic acid glucoside derivative ionic liquid can also be used as a multifunctional carrier to synergistically load other active ingredients; all the components achieve the triple synergistic effect of permeation enhancement, multi-channel blackness inhibition and barrier repair through molecular-level compounding, and the multi-channel whitening effect is achieved.

The application relates to the cosmetic technical field, and particularly discloses a double-continuous-phase makeup removing oil and a preparation method thereof. The makeup removing oil comprises an A-phase component and a B-phase component. The A-phase component comprises squalane, isopropyl palmitate, isopropyl myristate and an emulsifier I. The B-phase component comprises almond oil, cocoyl caprylate / caprate, dicaprylyl carbonate, olive oil, olive fermented oil, grape seed oil, colorless jojoba oil, burre hard hickory seed oil, sea fennel callus culture filtrate, damascan rose oil, comfrey oil, alpha-bisabolol, an antioxidant and an emulsifier II. The makeup removing oil has good permeability and self-emulsification, complete makeup removing effect, mildness and no irritation, and good skin care and nourishing effects. After the A-phase component is prepared, the B-phase component raw materials are mixed and stirred to obtain the makeup removing oil. The preparation method is simple, the preparation condition is mild, and the method is suitable for industrial production. The obtained makeup removing oil is easy to clean after use, has complete makeup removing effect and a fresh skin feel.

The present application relates to the technical field of asiatic acid, and particularly relates to an asiatic acid derivative and a preparation method. The asiatic acid derivative provided by the present application has R which is an alkyl group formed by removing a hydroxyl group from a saturated or unsaturated monohydric alcohol, and the saturated or unsaturated monohydric alcohol includes one of ethanol, octanol, hexadecanol, stearyl alcohol, 2-hexyl-1-decanol, decyltetradecin, oleyl alcohol, cis,cis-9,12-octadecadienol and bisabolol. The asiatic acid derivative of the present application has higher water solubility and oil solubility, especially oil solubility, so that the asiatic acid derivative has obviously enhanced liposolubility, is easily soluble in natural oil, alkane and other ester solvents, and has a significant inhibitory effect on EDNRA and TRPV1 and obviously enhanced bioactivity. The asiatic acid derivative of the present application has high availability, and the asiatic acid derivative has no safety risk.

This invention belongs to the technical field of cosmetics and topical skin preparations, specifically relating to a naturally derived composition and its application in products with repairing, soothing, and moisturizing properties. The invention provides a naturally derived composition comprising egg yolk oil, prickly pear fruit oil, and bisabolol; the mass ratio of the egg yolk oil, prickly pear fruit oil, and bisabolol is (1~50):(0.1~10):(0.01~1). The naturally derived composition provided by this invention, by combining egg yolk oil, prickly pear fruit oil, and bisabolol in a reasonable ratio, can achieve a synergistic effect, acting synergistically on the key mechanisms and targets of skin problems such as diaper rash and drool rash in infants, effectively preventing and treating common skin problems in infants and maintaining healthy skin; it is also natural, gentle, and suitable for infants.

The present invention provides a cosmetic composition for improving skin, which comprises sweet bisabolol, americol, a polygonum cuspidatum extract, chrysin, quercetin, sodium mannose phosphate, kaempferol and pyruvate. The composition for improving skin according to the present invention exhibits an excellent synergistic effect on strengthening skin barrier, inhibiting pigmentation, improving wrinkles, or strengthening elasticity by means of a combination of specific components, and thus can be effectively used as a functional composition in a cosmetic or an external preparation for skin, which targets skin tissue.

The invention provides a method for reducing the content of farnesol in (-)-alpha-bisabolol based on an oxidation process, and belongs to the technical field of medicinal chemistry and biosynthesis. The method comprises the following steps: (1) impurity removal: mixing a (-)-alpha-bisabolol or (-)-alpha-bisabolol solution, an organic solvent and metal salt for reaction; (2) post-treatment; after the reaction is finished, an alkaline aqueous solution is added into a reaction solution obtained in the step (1), phase splitting is conducted, an organic phase is taken to be distilled and concentrated, a purified (-)-alpha-bisabolol product is obtained, and the content of farnesol is smaller than or equal to 0.05%. Compared with an existing method, the method has the advantages of being easy to operate, free of by-products, low in cost, easy to amplify production and the like, a brand new solution is provided for improving the quality and use safety of the bisabolol, and an efficient, green and safe industrialization scheme is provided for application of the bisabolol in the field of cosmetics.