104 results about "Bisabolol" patented technology

The invention relates to a light loss repairing composition for improving skin resistance and application of the light loss repairing composition, and belongs to the technical field of cosmetics. The light loss repairing composition for improving the self resistance of the skin comprises the nannochloropsis oculata extract, the butterflybush flower extract and the bisabolol, all the components have a synergistic effect, ultraviolet light and blue light can be protected, and the light loss repairing composition has an anti-light aging effect and can be used for repairing the self resistance of the skin. And the mask has the effects of repairing skin barrier, relieving skin inflammation, improving redness, preventing hyperpigmentation, resisting aging, tightening skin, improving skin state and the like, and has the effect of improving self resistance of the skin.

The invention discloses cosmetic oil with whitening, soothing and anti-aging effects and a preparation method of the cosmetic oil. The plant essential oil is prepared from the following raw materials in parts by weight: 0.5 to 1.5 parts of sunflower seed oil, 0.01 to 0.05 part of lupinus albus seed extract, 0.0001 to 0.001 part of tocopherol, 0.01 to 0.05 part of rosemary leaf extract, 0.001 to 0.1 part of dimethyl methoxy benzodihydropyranol, 50 to 90 parts of caprylic / capric triglyceride, 0.01 to 0.2 part of ascorbyl tetraisopalmitate, 0.01 to 0.2 part of bisabolol, 5 to 20 parts of squalane, 2 to 8 parts of simmondsia chinensis seed oil, 5 to 15 parts of meadowfoam seed oil and 0.1 to 1 part of lavender oil. And 0.3-1 part of a centella asiatica extract. According to the cosmetic oil product provided by the invention, by optimizing the use of substances, the composition has triple effects of whitening, relieving and resisting aging, can meet multiple skin care requirements of consumers at the same time, and is wide in market application range.

The invention belongs to the technical field of cosmetics, and relates to a multichannel multi-target accurate delivery anti-allergy soothing nano-composite and a preparation method and application thereof, glycyrrhizic acid, bisabolol, 4-tert-butyl cyclohexanol and hydroxyphenyl propionamide benzoic acid are selected as anti-allergy soothing functional components. Comprising the following raw materials in percentage by mass: 0.1-5wt% of glycyrrhetinic acid; 0.1 to 10 weight percent of bisabolol; 0.001 wt% to 1 wt% of 4-tert-butyl cyclohexanol; 0.01 to 1 wt% of hydroxyphenyl propionamide benzoic acid; 10 to 50 wt% of an emulsifier; 1 to 20 wt% of a liquid lipid; 1 to 10 wt% of a co-emulsifier; 10 to 30 wt% of a polyol; and the balance of water. The sum of the mass percentages of the components is 100%. According to different passages of different active ingredients, the four active ingredients are simultaneously loaded in the same composition, so that multi-passage and multi-target accurate delivery can be realized, the skin can be timely and efficiently relieved from the source, the uncomfortable symptoms of the skin can be solved, and the immunity of the skin can be improved.

The invention discloses a wet tissue liquid for improving hemorrhoid symptoms, a wet tissue, a production method and application, the wet tissue liquid comprises asiaticoside, a sophora flower charcoal extract, bisabolol, a honeysuckle flower extract, a rosemary extract, ceramide NP, D-panthenol, potassium cocoyl glycinate, citric acid, sodium citrate and purified water, and the wet tissue comprises spunlace non-woven fabric. The wet tissue liquid is loaded on a non-woven fabric, the production process of the wet tissue liquid comprises a pretreatment stage, a preparation stage and a filtering stage, and the produced wet tissue liquid is applied to hygienic products for improving hemorrhoid symptoms. The sophora flower charcoal extract is used for the haemorrhoids wet tissue liquid to achieve the effects of stopping bleeding, cleaning and mildly easing pain; double natural extracts are compounded to replace preservatives, traditional single symptom relief is upgraded to symptom treatment, mucous membrane repair and barrier protection, disease deterioration and recurrence risks are reduced, and the composition is free of chemical preservatives, free of irritant surface activity and suitable for being used by people with hemorrhoid symptoms.

The invention discloses a recombinant bacterium capable of increasing the yield of alpha-bisabolol as well as a preparation method and application of the recombinant bacterium, and belongs to the technical field of microorganisms. The invention aims to improve the yield of alpha-bisabolol and enhance the tolerance of a host to an organic solvent. The invention provides a recombinant bacterium for improving the yield of alpha-bisabolol. Escherichia coli is used as a starting strain; the method comprises the following steps of: overexpressing an acetyl CoA acyltransferase / HMG-CoA reductase mvaE gene, an HMG-CoA synthetase mvaS gene, a 2-methyl citrate dehydratase prpD gene, a mevalonate kinase ERG12 gene, a mevalonate 5-phosphate kinase ERG8 gene, a mevalonate 5-diphosphate decarboxylase ERG19 gene and an isopentenyl diphosphate isomerase idi gene, so as to obtain a recombinant vector; the gene is obtained from an alpha-bisabolol synthase gene of artichoke, a farnesyl diphosphate synthase ispA gene and an alpha-bisabolol synthase CcBOS gene of artichoke. The industrial process of synthesizing alpha-bisabolol by a biological method is promoted.

The invention discloses a traditional Chinese medicine combination effective part capable of improving diabetic peripheral neuropathy. The traditional Chinese medicine combination effective part is prepared from a volatile oil effective part, a water-soluble effective part and an alcohol-soluble effective part, the effective part of the volatile oil comprises alpha-ocimene, alpha-santalene, bisabolol, beta-bisabolol and nerolidol; the water-soluble effective part comprises salvianolic acid A, salvianolic acid B and tanshinol; the alcohol-soluble effective part is prepared from Z-ligustilide, alpha-masticinic acid, beta-masticinic acid, tanshinone IIA, and 2-methoxy-5-acetyl-furangermacane-1 (10)-ene-6-ketone, and the alcohol-soluble effective part is prepared from the following raw materials in parts by weight: 2-methoxy-5-acetyl-furangermacane-1 (10)-ene-6-ketone. The traditional Chinese medicine composition effective part provided by the invention can regulate blood sugar, improve the conduction speed of sciatic nerves, repair damaged tissues, inhibit oxidative stress reaction, resist inflammation and relieve pain, so that the diabetic peripheral neuropathy is improved, the curative effect is reliable, the safety is good, the adverse reaction is low, and the traditional Chinese medicine composition effective part can be used for preparing a medicinal preparation for improving the diabetic peripheral neuropathy.

The invention discloses supramolecular liquid crystal cream and a preparation method thereof, and relates to the technical field of cosmetic preparation. Comprising 0.3%-2% of supramolecular 10-hydroxydecanoic acid-alpha-bisabolol, 1.5%-5% of an emulsifier, 0.5%-3% of behenyl alcohol, 6.8%-23% of an emollient, 1.5%-6% of an emulsion stabilizer, 0.95%-2.85% of a thickener, 5%-14% of a humectant, 0.6%-1.8% of a preservative and a proper amount of water. Wherein the emulsion stabilizer comprises cetostearyl alcohol, and the mass ratio of the cetostearyl alcohol to the behenyl alcohol is (0.5-2): (0.5-3); the thickening agent comprises at least one of xanthan gum, microcrystalline cellulose / cellulose gum and bentonite. The specific thickening agent and the long-chain fatty alcohol emulsion stabilizer are added into the supramolecular system, so that ordered arrangement of liquid crystals in the supramolecular system is remarkably promoted, the mechanical strength of the lamellar liquid crystals is improved, and the stability of the supramolecular liquid crystal system is further improved.

Retinol-based composition. The present invention relates to a composition, particularly a cosmetic one, especially for makeup and / or the treatment of keratinous materials, comprising at least one retinoid, in particular retinol; bisabolol; 4-t-butylcyclohexanol; niacinamide; and D-panthenol. Figure for the abstract: None

The invention relates to the technical field of biology, and particularly discloses pichia pastoris as well as a construction method and application thereof. According to the pichia pastoris disclosed by the invention, beta-glucan is knocked out to synthesize a related gene gas1. By deleting the beta-glucan coding gene gas1 gene of the pichia pastoris cell wall, the cell size is reduced, the transmission distance from the cell surface to the cell nucleus is reduced, oxygen transmission and product secretion during high-density culture are improved, and the fermentation production efficiency is improved. In addition, the pichia pastoris constructed by the invention enhances the synthesis of the intracellular product bisabolol, and also can enhance the secretion ability of the intracellular product bisabolol. By reducing the cell size, reducing the carbon flow flowing to the cell wall polysaccharide synthesis and increasing the carbon source flowing to the target product synthesis, the application has great significance in industrial production.

The application provides a method for separating and purifying bisabolol from fermented residue of bisabolol, which comprises the following steps: taking the fermented residue of bisabolol, stirring with an organic solvent, filtering, taking the filtrate to decolorize, and distilling the decolorized liquid to obtain the bisabolol. The preparation method can successfully obtain high-purity bisabolol, and has the advantages of simple operation, low cost and low solvent toxicity.

The invention relates to the field of scalp water, in particular to scalp water with moisturizing, soothing and tightening effects as well as a preparation method and application of the scalp water. According to the scalp lotion, the active ingredients such as the perigord truffle extract, the mistletoe extract, the artemisia capillaris extract and the denseflower rodendranthus herb extract are selected, and the raw materials such as the humectant, the tripeptide-1, the witch hazel extract, the dipotassium glycyrrhizinate and the bisabolol with the moisturizing, relieving and tightening effects are selected, so that the scalp lotion has the moisturizing, relieving and tightening properties; meanwhile, selection of the raw materials is optimized, the process and matching of the extracts are improved, and the performance of tightening the scalp, relieving the scalp and the like is further improved.

The present application provides a kind of microalgae source glycerol glucoside preparation and its preparation method and application, belong to medical technical field.The crude extract solution is obtained by low-osmotic extraction liquid extraction to salt stress algal mud, impurity is removed by filtration, and phycocyanin concentrated solution and glycerol glucoside containing permeate are obtained by membrane filtration separation, glycerol glucoside containing permeate is concentrated, bleaching and desalting, drying, and microalgae source glycerol glucoside is prepared, is mixed uniformly with gypenoside and bisabolol, and the mixture is prepared, after being embedded with oleic acid modified cholesterol and phospholipid to prepare modified liposome, mixed with chitosan solution and reacted, centrifuged, and the supernatant is discarded, and the solid is washed and dried to prepare microalgae source glycerol glucoside preparation.The present application realizes the technical effects of microalgae resource green low-carbon high-value utilization, product efficient purification, multi-target point synergistic anti-inflammatory and high transdermal absorption retention, and provides a kind of safe and effective, long-term use natural source new choice for treating atopic dermatitis externally.

A heatable aerosol-generating article is provided, including: an aerosol-generating substrate, including a homogenised chamomile material, the homogenised chamomile material including at least 2.5 percent by weight of chamomile particles on a dry weight basis, an aerosol former, and a binder, at least 20 micrograms of bisabolol oxide A per gram of the aerosol-generating substrate, on a dry weight basis, at least 100 micrograms of tonghaosu isomers per gram of the aerosol-generating substrate, on a dry weight basis, and at least 15 micrograms of alpha-bisabolol per gram of the aerosol-generating substrate, on a dry weight basis; and at least one hollow tube immediately downstream of the aerosol-generating substrate. An aerosol-generating system, including an aerosol-generating device including a heating element, and a heatable aerosol-generating article, is also provided.

The invention relates to the technical field of skin care products, and discloses a skin soothing and repairing agent based on a hydroxyapatite microsphere composite material and a preparation method thereof, the skin soothing and repairing agent comprises the following raw materials by weight: 0.75-1.95 parts of tetrahydromethylpyrimidine carboxylic acid; 0.25 to 0.75 part of bisabolol; 1 to 2.3 parts of nicotinamide; 5 to 15 parts of hydroxyapatite microspheres; the repairing agent is efficiently loaded and slowly released, the porous structure of the hydroxyapatite (HAP) microspheres can efficiently adsorb relieving active matter, long-acting slow release is achieved through physical adsorption, and instantaneous high-concentration stimulation is avoided.

This invention discloses the application of α-bisabolol in the preparation of a quorum sensing quencher for Serratia liquefaction. It belongs to the field of pharmaceutical technology. The purpose of this invention is to provide an application in the preparation of a quencher for inhibiting the quorum sensing system of Serratia liquefaction, thereby reducing the toxicity of pathogenic bacteria without inhibiting their growth. This invention provides an application of bisabolol in the preparation of a quencher for inhibiting the quorum sensing system of Serratia liquefaction. It offers a novel solution for developing efficient and safe food preservatives.

The application relates to the technical field of enzyme engineering, in particular to a (-)-alpha-bisabolol synthase mutant and application thereof. On the basis of a wild-type (-)-alpha-bisabolol synthase (SEQ ID No: 1), three types of (-)-alpha-bisabolol synthase mutants are constructed through substitution, deletion and addition mutation modes, and the (-)-alpha-bisabolol synthase activity of homologous mutants with different consistency obtained through the above different mutation modes is investigated, and the yield ratio relative to the wild type when used for fermentative production of (-)-alpha-bisabolol is investigated. It is proved that the above mutants all achieve the same or higher (-)-alpha-bisabolol yield as the wild-type (-)-alpha-bisabolol synthase. It is proved that the above mutation modes and the obtained mutants and the recombinant cells for biosynthesizing the mutants can be used for batch production and popularization of (-)-alpha-bisabolol, thereby helping the development of many downstream industries such as beauty and medicine.

This application relates to the field of biotechnology, specifically disclosing a *Pichia pastoris* yeast, its construction method, and its applications. This application involves knocking out the *gas1* gene, which is related to β-glucan synthesis, in *Pichia pastoris*. By deleting the *gas1* gene, which encodes β-glucan in the cell wall of *Pichia pastoris*, this application reduces cell size, decreases the transfer distance from the cell surface to the nucleus, improves oxygen transfer and product secretion during high-density culture, and enhances fermentation efficiency. Furthermore, the *Pichia pastoris* yeast constructed using this application enhances the synthesis of the intracellular product bisabolol and also enhances its secretion capacity. This application, by reducing cell size and decreasing the carbon flow to cell wall polysaccharide synthesis while increasing the carbon source flow to target product synthesis, has significant implications for industrial production.

The invention provides a high-concentration hydrogen peroxide emulsion for treating senile plaques and application thereof, and in the high-concentration hydrogen peroxide emulsion, hydrogen peroxide is used as an active component, can oxidize and decompose melanin in skin, and has a freckle removing effect; the hydrogenated polydecene is used as an emollient, so that the skin can be moistened and the texture of the skin is improved; hydrogenated castor oil (PEG-40) is used as an emulsifier, so that an emulsion system is stable; the bisabolol has anti-inflammatory and soothing effects, and can relieve the irritation of hydrogen peroxide to the skin; citric acid can adjust the pH value of the emulsion, so that the emulsion is more suitable for the physiological environment of skin; sodium hyaluronate has a moisturizing effect and can enhance the barrier function of skin. All the components have a synergistic effect, so that the emulsion has a good senile plaque treatment effect, and meanwhile, irritation to skin is reduced.

The invention relates to the technical field of cosmetics, in particular to a blue copper peptide-containing cosmetic as well as a preparation method and application thereof. Specifically, the transdermal composition containing the blue copper peptide comprises an active component tripeptide-1 copper and a transdermal synergistic component composed of methyl glucitol polyether-20 and hydrogenated lecithin according to the mass ratio of (5-15): 1, and the transdermal absorption rate and the storage stability of the blue copper peptide can be synergistically improved by the system; and / or the blue copper peptide synergistic composition comprises tripeptide-1 copper and a second active component composed of glycyrrhetinic acid and bisabolol, the mass ratio of the tripeptide-1 copper to the second active component is 1: (0.5-5), and the composition can generate a synergistic anti-inflammatory repair effect. According to the cosmetic disclosed by the invention, the technical bottlenecks that the blue copper peptide is poor in stability and difficult in transdermal penetration in cosmetics and cannot fully exert the effect in an inflammatory environment are effectively solved through independent or combined application of the composition.

The invention discloses a preparation method of high-absorptivity bisabolol, relates to the technical field of natural product chemistry, and solves the problem of insufficient preparation methods of bisabolol in the prior art. The key point of the technical scheme is that the preparation method comprises the following steps: a) supercritical CO2 extraction: crushing compositae plant raw materials to 40-60 meshes; performing three-stage gradient extraction under the conditions that the pressure is 25-35 MPa, the temperature is 45-55 DEG C and the flow rate of CO2 is 15-25 L / h, the extraction time is 2-3 hours, and an entrainer is 0.1-0.5% ethanol; the method has the effects that a supercritical CO2 extraction technology is adopted, so that organic solvent residues are avoided, and the safety of the product is improved; the molecular distillation purification further improves the purity of the bisabolol; according to the nanocrystallization technology, the size of the bisabolol crystal is remarkably reduced, the specific surface area is increased, and the solubility and permeability of the bisabolol in the skin are improved; the freeze-drying process maintains the nanostructure and activity of bisabolol, and improves the stability and bioavailability of the product.

The invention belongs to the technical field of biological pharmacy, and particularly relates to a sweet osmanthus lipstick for preventing and treating cheilitis and fading cheilogramma. In the composition disclosed by the invention, the osmanthus fragrans extract can reduce transcription of proinflammatory factors by inhibiting two signal channels of NF-kB and AP-1, so that generation of inflammatory mediators is reduced; the bisabolol has remarkable anti-inflammatory and soothing effects and can effectively relieve inflammation symptoms such as red and swollen lips and pain. The radix arnebiae seu lithospermi extract has the effects of clearing away heat and toxic materials and cooling and activating blood, and further enhances the anti-inflammatory effect. Phytosphingosine can promote repair and regeneration of lip cells and accelerate healing of damaged lip skin.

The invention relates to the field of cosmetics, in particular to cleansing oil and a preparation method of the cleansing oil. Comprising the following components in percentage by weight: 15%-25% of cetyl ethyl hexanoate, 2%-5% of diisostearyl malate, 8%-12% of ethylhexyl palmitate, 15%-25% of isohexadecane, 10%-20% of rice chaff oil, 0.1%-1% of simmondsia chinensis seed oil, 0.1%-1% of meadowfoam seed oil, 0.1%-1% of silybum marianum seed oil, 0.1%-1% of macadamia nut seed oil, 2%-5% of PEG-7 glyceryl cocoate and 10%-15% of polyglycerol-10 dioleate. The invention discloses cleansing oil and a preparation method thereof, and the cleansing oil comprises the following components in percentage by weight: 20-30% of cleansing oil, 3-6% of polyglycerol-dioctanoate, 0.01-0.1% of ascorbyl tetraisopalmitate, 0.05-0.3% of tocopheryl acetate and 0.1-0.3% of bisabolol. The cleansing oil and the preparation method thereof provided by the invention solve the problems that the cleaning efficiency and the mildness of the existing cleansing oil are contradictory, and the existing cleansing oil lacks antioxidant and repairing effects.

The invention provides a method for recycling a heavy phase generated in a process of producing (-)-alpha-bisabolol by a biological method, and belongs to the technical field of biosynthesis. The method comprises the following steps: (1) heavy phase pretreatment: adding a heavy phase containing (-)-alpha-bisabolol into a solvent, and then decolorizing to obtain a decolorized solution; (2) distillation: distilling the decolorized solution obtained in the step (1) to obtain a (-)-alpha-bisabolol crude product; and (3) molecular distillation: carrying out molecular distillation on the crude product obtained in the step (2) to obtain the (-)-alpha-bisabolol. According to the method disclosed by the invention, a high-purity (-)-alpha-bisabolol product is obtained from a heavy phase generated in the process of producing (-)-alpha-bisabolol by a biological method by adopting a simple process, so that the yield of (-)-alpha-bisabolol is improved, and meanwhile, the problem of waste treatment in the process of producing (-)-alpha-bisabolol by the biological method is solved; good application prospects are realized.

The present invention relates to a composition comprising delta-9-tetrahydrocannabinol (THC), alpha-bisabolol, guaiol, beta-caryophyllene and at least one terpene selected from the group consisting of linalool, alpha-humulene, nerolidol, caryophyllene oxide, alpha-pinene, camphene, beta-pinene, beta-myrcene, limonene, eucalyptol, ocimene, gamma-terpinene, terpinolene, alpha-terpinene, para-cymene, isopulegol and geraniol. The invention also relates to a pharmaceutical formulation comprising such composition. The pharmaceutical formulation according to the present invention may be used in medicine, specifically in the treatment and / or prevention of diseases associated with pain such as chronic cancer pain, somatic pain, visceral pain, central neuropathic pain, peripheral neuropathic pain or complex pain syndromes.

The invention discloses a high-concentration azelaic acid acne-removing soothing emulsion, and belongs to the technical field of medicines and skin care products. The method successfully breaks through the technical bottleneck that the solubility of azelaic acid in a conventional water-oil system is extremely low (generally 1t; 1%). According to the invention, 13-19% high-mass-fraction stable loading of azelaic acid can be realized, the system is still kept in a uniform and transparent liquid state at room temperature and after high and low temperature circulation, no crystal is separated out, and the physical friction stimulation of azelaic acid solid crystal particles to the skin in the traditional formula is eliminated. Meanwhile, the bisabolol, capryloyl glycine and other components contained in the system have an instant soothing effect, chemical irritation of azelaic acid can be reduced, and skin tolerance and use comfort of the product are remarkably improved.

The invention discloses makeup removing wet tissue containing papain and a preparation method of the makeup removing wet tissue. The makeup removing wet tissue containing papain comprises a base material and a liquid composition, wherein the liquid composition comprises the following components in percentage by weight: 0.1 to 1.0 percent of compound enzyme or compound enzyme microcapsules, 2 to 4 percent of sodium cocoyl glutamate, 3 to 10 percent of capric triglyceride, 0.05 to 0.1 percent of centella asiatica extract, 0.02 to 0.05 percent of bisabolol and the balance of water. The invention also provides a preparation method of the makeup removing wet tissue bag, which comprises the following steps: firstly preparing the liquid composition, then soaking the spunlace non-woven fabric in the liquid composition, and then folding, sealing and packaging to obtain the makeup removing wet tissue bag containing papain. Compared with the prior art, the makeup removing wet tissue containing papain has the advantages of being good in makeup removing effect and moisturizing effect, small in skin irritation, capable of adjusting microbial flora on the skin surface, inhibiting growth of harmful bacteria, promoting generation of beneficial bacteria and the like.

The invention relates to the technical field of protease mutation, and discloses a bisabolol synthase mutant with high catalytic activity and application of the bisabolol synthase mutant. According to the method, alpha-bisabolol synthase derived from compositae herbaceous plant globe artichoke is taken as wild enzyme, mutants are virtually screened by applying a protein language model SaProt, a deep learning model Catapro and a protein stability prediction tool Dynaamt, and the effect of producing bisabolol is verified through experiments; according to the present invention, the mutants obtained by mutation of 11 specific amino acid sites such as D125N, F159Y, F159K, N346D, T372S, Y432F, N346S, D184E, N157E, E374A and T258S are obtained through the mutation of the above 11 specific amino acid sites; wherein through 96-hour shake flask fermentation and gas chromatography detection, the bisabolol yields of the obtained single-point mutation T258S and double-point mutation T258S / F159K are respectively increased by 72.6% and 90.2% compared with the wild type yield; the Kcat / Km value of the two-point mutation T258S / F159K is 4.57 times that of a wild type.

The invention discloses a composition for repairing a tough skin barrier of sensitive skin and a preparation method and application thereof, the composition for repairing the tough skin barrier of the sensitive skin comprises bisabolol, a ginger root extract and ceramide, and the mass ratio of the bisabolol to the ginger root extract to the ceramide is (0.001-5): (0.0001-1): (0.001-5). The bisabolol has anti-inflammatory and soothing effects; the ginger root extract has natural oxidation resistance and can help relieve damage of the external environment to the skin; ceramide can effectively supplement skin lipid and repair a damaged barrier structure. Under the synergistic effect of the bisabolol, the ginger root extract and the ceramide, uncomfortable symptoms such as redness and pruritus of sensitive skin can be quickly relieved, meanwhile, the skin barrier function is fundamentally enhanced, the skin tolerance and the water retention capacity are improved, and the composition can be applied to cosmetics as a composition for repairing the sensitive skin and strengthening the skin barrier.

The invention discloses a composition for rapidly removing acnes and acne marks and a preparation method thereof, relates to the field of material science, and aims to solve the problem that the existing product has side effects on skin due to strong stripping agents, drying agents, hormones and the like, preparation raw materials and a reaction device of the composition for rapidly removing acnes and acne marks are firstly prepared; the preparation method comprises the following steps: preparing glycerol, carbomer and deionized water, preparing bisabolol from farnesol with the purity of 99.99% and a palladium-carbon catalyst with the purity of 5%, preparing microcapsules from the preparation raw materials by adopting an emulsification-crosslinking method, optimizing the microcapsules by adjusting parameters, finally mixing the prepared microcapsules with the remaining glycerol, carbomer and deionized water, and uniformly stirring to obtain the bisabolol microcapsule. According to the composition for rapidly removing acnes and acne marks, the performance of the prepared product can be improved, and meanwhile pollution in the production process is reduced.

The invention relates to bisabolol for use as a miticide agent, the use of bisabolol as a miticide, a method for reducing or preventing an infestation of an animal by a mite, comprising exposing the mite to bisabolol, a composition adapted for use as a miticide agent comprising bisabolol, a strip adapted for use in apiculture comprising bisabolol and to a hive comprising bisabolol.