The invention relates to the field of medical treatment, in particular to a novel mask capable of maintaining beauty and keeping young and a medicine, and a preparation method thereof. A raw materialcomponent A comprises hot spring water, butylene glycol, glycerin, xanthan gum, hydroxyethyl cellulose, sodium hyaluronate, and disodium EDTA; a raw material component B comprises capryloyl hydroxamicacid, 1,2-hexanediol, propylene glycol, allantoin, and PEG-40 hydrogenated castor oil; and a raw material component C comprises a rose flower extract, a Dendrobium candidum extract, nicotinamide, sorbitol, glycine betaine, acrylic acid/MA copolymer sodium, caprylyl glycol, dipotassium glycyrrhizinate, a centella extract, palmitoyl pentapeptide-4, palmitoyl tetrapeptide-7, and palmitoyl tripeptide-1. The raw material component A is added to a homogenous pot, the material is stirred and heated to 70-80 DEG C, insulation is carried out for 20-30 minutes; the cooling water is used for cooling; when the temperature drops to 50 to 70 DEG C, the raw material component B is added, and stirred and cooled.