61 results about "Caprylic acid" patented technology

This application relates to the field of veterinary drug technology, and discloses a transdermal absorption-enhancing ointment and its preparation process. The ointment components include white petrolatum, anhydrous lanolin, caprylic / capric triglycerides, hydrophobic fumed silica, and a highly fluid active permeation-enhancing phase. The permeation-enhancing phase contains active drugs and soybean lecithin, which self-assemble to form an inverse micelle aggregate. Soybean lecithin cross-links with the silanol groups on the surface of silica to form an intermolecular hydrogen bond network, constructing a sterically hindered framework within a continuous lipid matrix to prevent the polar drug-loaded phase from permeating and separating upon heating. Simultaneously, the inverse micelle structure effectively improves the transdermal absorption rate of the drug. The preparation process controls the lipid crystallization kinetics through slow cooling under negative pressure and micro-shear dynamic rheology. This invention solves the problems of easy precipitation upon heating, low transdermal efficiency, and poor rheological properties in traditional ointments, resulting in a product with a stable physical structure and good pseudoplastic texture.

The application discloses a kind of enveloped virus inactivation preparation based on medium-chain triglyceride and application thereof, the present application relates to the technical field of biological medicine external preparation, including active ingredient and auxiliary material: the active ingredient includes: high-purity medium-chain triglyceride (MCT), preferably octanoic acid (C8) and capric acid (C10) triglyceride mixture, purity ≥99%; The auxiliary material includes: food-grade antioxidant, for preventing oxidation of preparation, the content of food-grade antioxidant is 0.01-0.05%w / w, with medium-chain triglyceride as active ingredient, through the physical and chemical synergistic effect, enveloped virus is efficiently killed, for treating stubborn skin mucosa infection diseases (such as stubborn flat warts, herpes labialis, genital herpes, etc.) caused by human papillomavirus (HPV), herpes simplex virus (HSV-1 / HSV-2), varicella-zoster virus and other enveloped viruses.

Provided is a beer-flavored beverage having an alcohol content of 10.0 (v / v)% or more, a real extract concentration of 10.5 (w / w)% or more, and an ethyl caprylate content of 25 ppb by mass or more.

In the present invention it has been found a pharmaceutical formulation comprising a GLP-1 peptide agonist; a C6-C9 fatty acid or a salt thereof or a combination of a C6- C9 fatty acid or a salt thereof and a salt of N-(8-(2-hydroxybenzoyl)amino)caprylic acid as the sole permeability enhancers can be used to increase the bioavailability of the peptide in the formulation. The salt of N-(8-(2-hydroxybenzoyl)amino)caprylic acid and the C6-C9 fatty acid each act as permeability enhancers, and improve the bioavailability of the peptide. The pharmaceutical formulation can be used in the treatment of diabetes mellitus and obesity.

The current invention describes a high-throughput catalytic process for the production of diesel fuel from domestic agricultural products, furfuraldehyde and plant fatty acids. In the present process, reacting medium and long chain fatty anhydrides (such as capric, caprylic, lauric and palmitic) with furfuraldehyde by a Perkin condensation produces 2-n-alkenylfurans. In a second step, the 2-n-alkenylfurans are hydrogenated to form 2-n-alkyltetrahydrofurans. Basic fuel property testing (melting point, density, kinematic viscosity, derived cetane number and calorific value) of the 2-n-alkyltetrahydrofurans indicates they are potentially useful as fuels for diesel engines. One mixture composed of 2-octyl- and 2-decyltetrahydrofuran had the best combination of fuel properties including a low melting point (−39° C.), high cetane number (63.1), high flash point (98.2° C.) and low viscosity (2.26 mm2 / sec, 40° C.) which compares favorably with specifications for diesel #2 and biodiesel.

This invention discloses a bio-based toughening agent-modified isosorbide polycarbonate and its preparation method, belonging to the technical field of isosorbide polycarbonate. The method includes the following steps: synthesis of a star-shaped polyester toughening agent, synthesis of isosorbide-decanediol copolycarbonate, and reactive blending. The method for synthesizing the star-shaped polyester toughening agent involves vacuum drying pentaerythritol at 105-115°C for 0.8-1.2 hours, mixing the dried pentaerythritol with ε-caprolactone and stannous octoate under nitrogen protection, heating to 125-135°C, and stirring the reaction under nitrogen atmosphere for 10-14 hours. After the reaction, cooling to 38-42°C, adding dichloromethane to completely dissolve the product, and precipitating it with cold methanol, followed by drying to obtain the star-shaped polyester toughening agent. The modified isosorbide polycarbonate prepared by this invention exhibits high toughness while maintaining excellent transparency.

This invention discloses a method for improving the distinctive fishy odor of frozen duck meat, belonging to the field of food processing technology. The method involves dissolving NY50C protease in water to form an enzyme treatment solution, uniformly injecting it into the duck meat, allowing it to stand at 4°C for 12-24 hours, and then freezing it. This method effectively reduces the content of typical fishy odor substances such as 1-octen-3-ol, 1-octen-3-one, and octanoic acid produced during the freezing process of duck meat without damaging the integrity of the myofibrillar protein gel network. It also shows a good inhibitory effect on rancid substances such as (E,E)-2,4-decadienal, and moderately retains oily aroma substances such as heptanal and octanal, thereby significantly optimizing the flavor profile of frozen duck meat. Furthermore, it improves the textural properties of frozen duck meat, maintaining suitable elasticity and chewiness, and preserving good color stability.

This invention provides a liquid crystal biomimetic water-locking and oxygen-permeable skincare composition, its preparation method, and its application, belonging to the field of cosmetic technology. It comprises the following components by weight percentage: 20-40% glycerin, 5-10% hydrogenated lecithin, 5-10% phytosterols, 0.1-0.5% sodium stearoyl glutamate, 0.01-0.05% sodium methylstearoyl taurate, 0.1-1% ceramide NP, 1-10% caprylic / capric triglyceride, 1-10% squalane, 0.1-1% tocopheryl acetate, 0.01-0.3% sodium DNA, 0.001-0.1% fibronectin, 0.001-0.1% soluble collagen, and the balance being water. The liquid crystal biomimetic water-locking and oxygen-permeable skincare composition provided by this invention can better form a breathable protective film on the skin surface, reduce skin moisture loss, and help repair damaged skin barriers, thereby achieving the effect of water-locking and oxygen-permeable skincare.

The application discloses a long-acting makeup holding foundation liquid, which comprises water, titanium dioxide, hydrogenated polydecene, isododecane, isohexadecane, dimethicone, caprylic acid / capric acid triglyceride, dipropylene glycol, silica, polyglyceryl-2 dipolyhydroxystearate, synthetic fluorphlogopite, polymethylsilsesquioxane, a film forming agent, magnesium sulfate, cetyl PEG / PPG-10 / 1 dimethicone, lithium montmorillonite, triethoxysilane, ethanol, dimethicone / vinyl dimethicone crosspolymer, alumina, dimethiconol, collagen, natural extract, a colorant, a moisturizing agent and trace additives. The long-acting makeup holding foundation liquid has reliable water supplementing and moisturizing and oil control effects, can selectively absorb and control oil, has reliable skin friendliness, can reliably protect makeup of oily skin, and avoids the problem of makeup removal caused by facial oil secretion.

This invention discloses a universal method and composition for solving the pilling problem in cold-formulated cosmetics. Adding an effective amount of glyceryl oleate, citrate / caprylic / capric triglyceride to a cosmetic composition containing a pilling-prone cold-formulated emulsifier can significantly reduce or eliminate pilling. This substance has been discovered for the first time to have a novel anti-pilling application, effective against pilling caused by the emulsifier's own characteristics, high dosage, electrolyte interference, or the addition of large molecules, and is universally applicable to different types of cold-formulated emulsifier systems. This invention is particularly suitable for systems using electrolyte-rich natural plant extracts as the aqueous phase, fundamentally solving the pilling problem and providing a reliable solution for preparing high-feel, all-natural cold-formulated cosmetics.

The present invention provides a food product that is provided in a solid, tightly packed state that does not impair the flavor, allowing the original taste, flavor, taste, and aroma of the contained alcoholic beverage to spread in the mouth, and also contains a gel-like composition containing health-conscious functional ingredients. [Solution] This is an alcohol-containing jelly that is consumed directly from a tightly filled pouch container. The jelly consists of an alcoholic beverage, functional ingredients, a gelling agent, additives, and water. The functional ingredients are collagen peptide and animal placenta, and the additives include citric acid, flavorings, and sweeteners. The alcoholic beverage content is 10% to 95% by mass of the total alcohol-containing jelly, and the functional ingredients content is 1% to 10% by mass of the total alcohol-containing jelly. The volatilization of ethyl caproate, ethyl caprylate, and ethyl caprate, which are characteristic aroma components of the alcohol-containing jelly, increases by 1.6 to 2.0 times at 37°C compared to 30°C.

The application belongs to the technical field of plant extraction, and discloses a coffea arabica seed extract, a preparation method and application thereof, the preparation method adopts caprylic acid / capric acid triglyceride as an extraction solvent to extract the seed coat of the coffea arabica seed, and the coffea arabica seed extract is obtained. The method adopts caprylic acid / capric acid triglyceride as an extraction solvent to extract the coffee seed coat, and it is found through relevant tests that the coffea arabica seed extract has good free radical scavenging effect and good firming and anti-wrinkle functions.

The purpose of the present invention is to provide a food product provided in a tightly packed state that is solid and does not impair flavor, the food product being such that the savoriness, flavor, taste, and aroma inherent to an incorporated luxury-good alcohol spread in the mouth, and food product containing a gel composition that contains a health-oriented functional component. An alcohol-containing jelly according to the present invention is directly consumed from a tightly packed pouch container, the alcohol-containing jelly being characterized by comprising an alcoholic beverage, a functional component, a gelling agent, an additive, and water, and furthermore being characterized in that: the functional component includes a collagen peptide and an animal placenta; the additive contains citric acid, a flavoring, and a sweetener; the alcoholic beverage content is 10-95 mass% with respect to the entire alcohol-containing jelly; the functional component content is 1-10 mass% with respect to the entire alcohol-containing jelly; and the volatilization amounts of ethyl caproate, ethyl caprylate, and ethyl caprate, which are characteristic aroma components of the alcohol-containing jelly, are 1.6-2.0 times greater at 37°C than at 30°C.

This invention relates to a lip gel composition for reducing wrinkles and moisturizing, and its preparation method. The lip gel composition, by weight percentage, comprises: 0.5-1.5% dipalmitoyl hydroxyproline, 0.05-0.1% hybrid rose extract, 0.02-0.05% hyaluronic acid microspheres, 15-20% castor seed oil, 0.05-0.1% sunflower seed oil, 0.0005-0.001% β-carotene, 35-41% caprylic / capric triglycerides, and 32-50% octyl-dodecyl alcohol. The hyaluronic acid microspheres are composed of hyaluronic acid encapsulated in castor seed oil. The preparation employs a staged low-temperature mixing process: first, an oil phase carrier is formed at 60-80℃; then, a collagen activator is added for dispersion; and finally, the heat-sensitive active ingredients are integrated at ≤40℃. This solution breaks through the limitations of traditional lip products where efficacy and skin feel cannot be achieved simultaneously. Tests have shown that after 30 days of use, lip lines are reduced by more than 40%, and hydration is increased by more than 60% after 4 hours. Moreover, no synthetic preservatives or synthetic pigments are added throughout the entire process.

The application belongs to the field of daily chemicals, and discloses a refreshing oil-in-water macromolecular sunscreen system, which comprises a water phase, an oil phase and an organic sunscreen agent; the water phase is provided with a first surface active agent and a water phase thickening agent; the oil phase is provided with a second surface active agent; the amount of the organic sunscreen agent is 6-10 wt%; the solvent in the oil phase is composed of a first solvent and a second solvent; the first solvent is composed of dibutyl adipate, isopropyl lauroyl sarcosinate and cocoyl octanoate / caprate; the second solvent is composed of dicaprylyl carbonate and / or isononyl isononanoate, caprylic / capric triglyceride and C12-15 alcohol benzoate; the first surface active agent is chitosan lauryl carbamate; and the water phase thickening agent is an acrylate / isodecyl vinyl cross-linked polymer and xanthan gum. In the sunscreen system, the oily solvent is preferred, the emulsifier and thickening agent of the water phase are reasonably matched, the sunscreen performance is optimized, and the formula stability is maintained.

This invention belongs to the field of cosmetics and skincare products, and provides a sebum-mimicking microcrystalline assembly oil and its preparation method. It uses beeswax microcrystals as the core, intercellular lipid nanoparticles as the shell, and caprylic / capric triglycerides and squalane as the basic continuous phase of the assembly intermediate. In the final oil, these components together form a microcrystalline-liquid composite structure with a carrier oil, creating a continuous phase. By controlling the beeswax microcrystal particle size to 1-5 μm, the intercellular lipid loading relative to beeswax mass to 10-60 wt%, and the nanoparticle adsorption assembly process, it achieves high static support with a low shear viscosity of 1.0 × 10⁴-1.0 × 10⁵ mPa·s, shear-thinning characteristics with a high shear viscosity reduced to 300-1500 mPa·s, and a significant barrier repair effect with a reduction of at least 25% in transdermal water loss after 2-4 weeks of continuous topical application. This invention resolves the contradictions between shelf stability and lipid migration efficiency, and between high lipid loading and user comfort in existing oil-based repair systems, and has broad application value in skin barrier repair, sensitive skin care, and anti-aging skincare.

The application relates to the technical field of cosmetics, in particular to a double-dosage full-transparent shake milk and a preparation method thereof, the shake milk comprises an A phase and a B phase, the A phase comprises the following components: 3-10% of component No. 1, 3-10% of component No. 2, 1-5% of component No. 3, 1-5% of component No. 4, 2-10% of component No. 5, 0.01-1% of component No. 6, 0.05-0.15% of an emulsifier, 0.01-1% of an antioxidant; the emulsifier is a glycolipid, the component No. 1 is a coco-caprylate / caprate, and the component No. 2 is C9-12 alkane; the B phase comprises the following components: 0.01-0.5% of disodium EDTA, 0.001-0.2% of galactoarabinan, 0.01-0.15% of hydrolyzed sodium hyaluronate, 0.1-0.8% of a preservative, and the rest is water; the density difference between the A phase and the B phase is greater than or equal to 0.14593; the shake milk has the advantages that after the shake milk is shaken and then is left to stand, the water phase, the oil phase and the water-oil interface can reach a full-transparent state.

This invention provides characteristic compounds, quality control materials, reconstructing solutions, and applications of deer antler wine flavor, belonging to the fields of food flavoring and chemical engineering technology. Through experimental research, this invention has discovered six characteristic compounds in deer antler wine: hexanal, octanal, nonanal, myristal, ethyl benzoate, and ethyl octanoate. These six compounds are highly correlated with the flavor of deer antler wine, and the flavor can be reconstructed using these characteristic compounds, such as in the preparation of deer antler-flavored beverages. Furthermore, the flavor of deer antler wine can be altered by controlling the content of these characteristic compounds. Based on the content of these six compounds, this invention can determine the flavor of deer antler wine, enabling its grading and evaluation, reducing the influence of subjective factors in human evaluation, and facilitating industrialization and standardization.

This invention discloses a skin repair dressing containing ectoine and its preparation method, relating to the field of skin care technology. By weight, it comprises the following components: ectoine: 2-5 parts, panthenol: 1-3 parts, sodium hyaluronate: 0.05-0.1 parts, glycerin: 5.0-8.0 parts, trehalose: 0.5-1.5 parts, squalane: 3.0-5.0 parts, caprylic / capric triglyceride: 4.0-6.0 parts, cetyl ethylhexanoate: 3.0-5.0 parts, Montanov L: 2.0-4.0 parts, carbomer: 0.1-0.3 parts, and p-hydroxyethylhexanoate. Acetophenone: 0.3-0.5 parts, 1,2-hexanediol: 0.8-1.2 parts, triethanolamine: 0.1-0.3 parts, polyhexamethylene biguanide (PHMB): 0.01-0.03 parts, ceramide: 0.05-0.1 parts, with purified water as the balance, and the total weight of all components is 100 parts. This invention combines active ingredients such as ectoine to repair the skin in multiple dimensions, is suitable for various skin types, and adds antibacterial ingredients to make the effect more lasting. Standardized preparation process is adopted to control the parameters of each step, ensuring uniform and stable dressing, ensuring hygiene and safety, and achieving stable product quality and consistent effect.

FIELD: cosmetics.SUBSTANCE: cosmetic composition in the form of a cream-gel for skin cleansing contains purified water; an emulsifier consisting of cetyl alcohol, glyceryl stearate, PEG-75 stearate, ceteth-20 and steareth-20; glycerin; coco-glucoside; a co-surfactant consisting of purified water, glyceryl oleate and coco-glucoside; cetearyl alcohol; caprylic / capric triglyceride; panthenol; butylene glycol; squalane; oat extract; sodium acrylate / sodium acryloyldimethyl taurate copolymer; cocamidopropyl betaine; cholesterol; ceramide complex including: ceramides NP, AP, AS, NG, glycosphingolipids, hydrogenated lecithin and auxiliary components; fructooligosaccharides; hydroxyacetophenone; preservative consisting of 1,2-hexanediol and caprylyl glycol; tocopheryl acetate; fragrance; arginine and disodium EDTA, in a certain ratio of components, wt.%.EFFECT: relisble removal of impurities from the skin's surface, restoration of the damaged protective barrier of the skin during washing without causing excessive dryness of the skin, relief of irritation and moisturization of the skin.1 cl, 3 tbl, 4 ex

The application belongs to the technical field of cosmetics, and particularly relates to a liposome delivery system with high loading rate and oxidation resistance, and a preparation method and application thereof. The liposome delivery system comprises the following components in percentage by mass: 4-10% of a complex film material, 0.3-2% of carboxymethyl deacetyl chitin, 0.1-2% of tocopherol acetate, 0.1-2% of thioctic acid, 0.1-2% of carnosic acid, 50-80% of glycerol, 2-10% of ethoxydiglycol, 2-10% of caprylic / capric triglyceride, 2-3% of pH buffer, 0.1-10% of active ingredients, and the balance of water. The application optimizes the component proportion of the film material, the solvent system, the antioxidant, and the surface active / stabilizing agent, utilizes the synergistic effect among the components, realizes efficient wrapping of the active ingredients, and improves the oxidation resistance and storage stability of the liposome.

Provided are a biological patch, a preparation method therefor, and use thereof. The biological patch is a fish skin-based biological patch, and contains a first fatty acid and a second fatty acid. A mass percentage of the first fatty acid in the biological patch is greater than or equal to 1.4%, and a mass percentage of the second fatty acid in the biological patch is less than or equal to 2.0%. The first fatty acid includes at least two of butyric acid, caprylic acid, lauric acid, myristic acid, pentadecanoic acid, etc. The second fatty acid includes an ω-6 unsaturated fatty acid. The biological patch includes collagen fibers with a certain diameter, and the biological patch includes micropores with a certain pore size and a certain porosity. The preparation method for the biological patch includes degreasing, pigment removal, and decellularization. The obtained biological patch is used for repairing soft tissue or used as a skin repair dressing. The biological patch can reduce or eliminate inflammatory response of an administration site, and exhibit good mechanical performance and degradation performance.

The present invention relates to a method for purifying a target protein to remove impurities such as host cell proteins (HCPs), a method for producing a target protein using same, and a hyaluronidase or a variant thereof obtained by using the method. When a target protein is purified using the method according to one aspect, HCPs can be effectively removed while improving the yield and / or purity of the target protein, and thus the method can be applied in a process of producing a recombinant protein such as a hyaluronidase or a variant thereof.

The present application provides a kind of based on acrylic polymer stabilizing system milk white essence and its preparation method, simultaneously as emulsifying agent and thickening agent, the acrylic acid ester class / C10-30 alkyl alcohol acrylic ester crosslinking polymer (Pemulen TR-1) in prior art is used as formula auxiliary component, constructs a formula framework extremely simple, and can realize long-term physical and chemical stable milk white essence system, improves the mildness and reliability of formula from the source. By using single, safe, light synthetic oil (caprylic / capric triglyceride) as the only oil phase component, while ensuring the necessary lubricating feeling and active substance dissolving carrier, the system is extremely simple, stable and controllable. Create a mild physical and chemical environment, maximize the protection and maintenance of recombinant collagen and other sensitive bioactive ingredients in the shelf life of chemical integrity and biological efficacy.

The present application relates to a kind of high drug loading density somatostatin oral nanoparticles, the nanoparticles are spherical hydrophobic polyester material as carrier, several hydrophobic somatostatin ion pair complex particles are uniformly wrapped inside, and hydrophilic hydroxyethyl starch is grafted on the outer surface of polyester material, wherein the hydrophobic somatostatin ion pair complex is composed of somatostatin and counterion compound, and the counterion compound is at least one of sodium dodecyl sulfate, 8- (2-hydroxybenzamide) sodium octanoate, sodium oleate, sodium octanoate, sodium caprate, sodium laurate, sodium dodecyl sulfonate, sodium dioctyl sulfosuccinate;The hydrophobic polyester material is lactic acid-glycolic acid copolymer, polycaprolactone, polylactic acid.The nanoparticles are modified by hydroxyethyl starch, can quickly penetrate mucus barrier during oral delivery, and have high enterocyte penetration efficiency, can effectively improve the oral bioavailability of somatostatin.

The application discloses a polyester sponge for automobile interior decoration and a preparation process thereof, and relates to the technical field of polyester sponge preparation, and comprises the following component raw materials: polyester polyol, polytetrahydrofuran ether diol, deionized water, foam stabilizer, catalyst, stannous octoate, modified ethylene glycol, modified castor oil-based epoxy ester, nano fumed silica, modified hydroxymethyl phenyl phosphinic acid ester, functional agent and toluene diisocyanate 80 / 20. In the application, the modified ethylene glycol can form a stable and uniform three-dimensional crosslinking network inside the polyester sponge, effectively improves the tensile strength, tear strength and structural stability of the sponge, reduces the compression permanent deformation rate and high-temperature dimensional shrinkage rate, makes the sponge support more balanced, and is not easy to collapse and deform during long-term use, so that the durability and form maintaining capacity of the sponge are obviously improved.

This invention discloses a pharmaceutical composition for treating chapped skin caused by tinea pedis and manuum. The composition comprises urea, olive leaf extract, oat alkaloids, and asiaticoside as active ingredients, combined with a hypoallergenic liquid crystal emulsion matrix consisting of shea butter, squalane, caprylic / capric triglycerides, and cetearyl glucoside. This invention utilizes urea to soften keratin and promote crack healing, while simultaneously inhibiting the irritation caused by urea through the synergistic effect of three plant-based anti-inflammatory components, and combining biomimetic oils to repair the skin's lipid barrier. This composition significantly reduces pain and itching at the chapped areas in patients with tinea pedis and manuum, promotes crack closure, and avoids the burning and irritation commonly found in traditional antifungal ointments.