793 results about "Caprylic acid" patented technology

The invention discloses a scalp essence capable of controlling oil and removing dandruff and a preparation method thereof, and provides the scalp essence capable of controlling oil and removing dandruff. The formula consists of the following raw materials: water, saccharomycetes / rice fermentation product filtrate, butanediol, phenoxyethanol, caprylic acid / capric triglyceride, galactose yeast-like bacterium fermentation product filtrate, allantoin, a saccharomycetes / zinc fermentation product, nicotinamide, arginine, polysorbate-20, hydrogenated lecithin, acrylic acid (ester) / C10-30 and an alkanol acrylate cross-linked polymer. Hydrolyzed sodium hyaluronate and trace components. According to the oil-controlling and dandruff-removing scalp essence disclosed by the invention, through the synergistic interaction among the raw materials, the effects of replenishing water, preserving moisture, controlling oil and removing dandruff are increased, the effects of relieving, recovering oil-water balance, recovering skin elasticity and delaying senescence are also achieved, the effects of preventing hair loss and nourishing hair are also achieved, and meanwhile, the oil-controlling and dandruff-removing scalp essence has the advantage of being stable in storage.

The invention discloses an alcohol dehydrogenase mutant and application of the alcohol dehydrogenase mutant in asymmetric synthesis of (S)-6-hydroxy-8-chloro ethyl caprylate with optical purity. The alcohol dehydrogenase or the mutant thereof provided by the invention has extremely high conversion rate and can effectively improve the optical purity of the product. Moreover, based on the mutant, low-cost, efficient and rapid production of single-configuration ethyl 6-hydroxy-8-chloro caprylate can be realized, a multi-configuration mixture is not generated, and the problems of tedious steps, pollution and the like caused by a conventional chemical synthesis method are also avoided.

The invention discloses a composition for regulating micro-ecological balance of skin and application of the composition in cosmetics, and the composition is prepared from the following components in percentage by mass: 5-15% of capryloyl hydroximic acid, 0.1-2% of glycerol caprylate and 5-15% of ethylhexylglycerin. The composition can synergistically inhibit harmful bacteria, has a poor inhibition effect on beneficial bacteria, effectively adjusts the proportion of the beneficial bacteria to the harmful bacteria of the skin, further effectively adjusts the micro-ecological balance of the skin, reconstructs the micro-ecological environment of the skin, and is beneficial to the health of the skin.

The invention relates to a eutectic microcapsule wrapping technology and application thereof in cosmetics, and belongs to the technical field of cosmetic production. The wall material of the eutectic microcapsule inclusion comprises at least one of hydrogenated lecithin, caprylic / capric triglyceride, sucrose stearate, PEG-8 caprylic / capric glycerides, PEG-40 hydrogenated castor oil, soya bean lecithin, cyclodextrin, ethyl palmitate and troxerutin. The core material is prepared from at least one of salicylic acid, 4-butylresorcinol, glabridin, a kava extract, cortex magnoliae officinalis total phenols, ginseng oil, ganoderma lucidum spore oil, astaxanthin, coenzyme Q-10, a rosemary extract, ceramide and vitamin E. According to the invention, multiple eutectic coating can be formed, the consumption of the wall material can be reduced, the cost is saved, the wall material and the core material are matched for use, so that the excellent effects of permeation, oxidation resistance, soothing, allergy resistance and skin repair can be achieved, and the utilization rate of active substances is increased.

The present invention provides: a fermented beer-like sparkling beverage having a real fermentation degree of 60% or less and a value of ([real extract (w / v%)]-[real final extract (w / v%)]) / [real extract (w / v%)] × 100 of 20% or less; the fermented beer-like sparkling beverage having a value of [original wort extract (w / v%)] × [malt ratio (w / w%)] of 1200 or less; and any one of the above-mentioned fermented beer-like sparkling beverages, in which the ratio (Es / HA) of the total concentration (mg / L) (HA) of ethyl acetate, isoamyl acetate, ethyl caproate, ethyl caprylate, and β-phenethyl acetate to the total concentration (mg / L) (Es) of isobutanol, isoamyl alcohol, and β-phenethyl alcohol in the beverage is 15% or less.

The invention relates to the technical field of household articles, and discloses a memory foam pillow with a sleep aiding effect, which comprises a body, wherein the interior of the body comprises a layer of bio-based memory foam and a layer of pressure regulating silica gel layer; the bio-based memory foam is prepared by reacting polylactic acid and vegetable oil-based polyurethane under the action of a catalyst tin octanoic acid, wherein the mass ratio of the catalyst is 0.1%; the pressure-regulating silica gel layer is formed by mixing silicone oil and a cross-linking agent according to a volume ratio of 1: 0.05 and then reacting at 60 DEG C for 24 hours; the memory foam pillow further comprises microencapsulated lavender essential oil and a phase change material, wherein the loading amount of the lavender essential oil is 5% of the total mass of the foam. By combining the memory foam and the pressure regulating silica gel layer, the shape and hardness of the pillow can be automatically adjusted according to the sleeping posture of a user, muscle tension and pain are avoided, deeper rest is promoted, the number of times of waking up at night is reduced, and the sleeping quality is remarkably improved.

The invention discloses a method for detecting a chiral isomer of 6-hydroxy-8-chloro ethyl caprylate. The method comprises the following steps: carrying out gas chromatography detection on a test solution containing R-6-hydroxy-8-chloro ethyl caprylate and S-6-hydroxy-8-chloro ethyl caprylate, wherein the gas chromatography detection is carried out on the test solution containing R-6-hydroxy-8-chloro ethyl caprylate and S-6-hydroxy-8-chloro ethyl caprylate; the conditions of the gas chromatography detection are as follows: a chromatographic column is selected from a chiral chromatographic column containing beta-cyclodextrin; the chromatographic column adopts programmed heating in the detection process, the initial column temperature is 120-180 DEG C, the final column temperature is 190-220 DEG C, and the heating rate is 0.5-2.0 DEG C / min. The method is based on a gas chromatographic method, adopts a beta-cyclodextrin-containing chiral chromatographic column, and is combined with programmed heating at a specific initial column temperature heating rate, so that the two chiral isomers of 6-hydroxy-8-chloro ethyl caprylate can be separated and detected, the sensitivity is high, the specificity is good, and the separation degree meets the standard; the method has important significance on preparation of single-configuration lipoic acid.

The invention discloses a composition with a red fading effect and application thereof. The composition is prepared from the following components in percentage by mass: 90 to 99 percent of fat-soluble solvent and 1 to 10 percent of saururus chinensis extract, wherein the fat-soluble solvent is selected from at least one of glycol, caprylic / capric triglyceride, sunflower seed oil, macadamia nut oil, meadowfoam seed oil, silicone oil, squalane, ethylhexyl palmitate, diisostearyl malate, polyglycerol-2 triisostearate, camelina seed oil, octyldodecanol and coconut oil alcohol-caprylate / caprate. The composition prepared by mixing the saururus chinensis extract and the fat-soluble solvent has a very remarkable red fading effect.

This invention discloses a method for preparing an air-based hydrophilic-oleophobic coating, comprising the following steps: a) adding a silane coupling agent to ethanol to obtain solution A; b) first adding perfluorooctanoic acid and sodium hydroxide to ethanol to obtain a sodium perfluorooctanoate ethanol solution, then adding at least two types of hydrophilic nanoparticles of the same particle size to the sodium perfluorooctanoate ethanol solution to obtain solution B; c) adding a fluorinated surfactant and at least two types of hydrophilic nanoparticles of the same particle size to ethanol to obtain solution C; d) first mixing solution B and solution C uniformly to obtain solution D, then slowly adding solution A dropwise to solution D to obtain suspension E; e) spraying suspension E onto the surface of a substrate and drying at 55-65°C for 1-3 hours to obtain an air-based hydrophilic-oleophobic coating. The preparation method of this invention is simple, and the resulting coating exhibits excellent hydrophilicity and oleophobicity, acid and alkali resistance, salt resistance, and oil stain resistance.

The invention relates to the technical field of polymer degradable materials, in particular to a biodegradable material as well as a preparation method and application thereof. The material takes modified polylactic acid as a main body, and an antioxidant, a plasticizer, a flame retardant and an inorganic filler are used as auxiliary materials in parts by weight. The method is characterized in that lactic acid and an epicatechin imidazole ammonium chloride polymer are polymerized under the catalysis of stannous octoate, and an epicatechin bioactive group is introduced into a polylactic acid main chain in a chemical bonding manner, so that the biodegradation rate, the mechanical property and the thermal stability of the material are remarkably improved. Bioactive substances and ionic groups in the material promote microbial degradation, and the material can be completely decomposed in a compost environment in a short time; meanwhile, the strength, the toughness and the high-temperature processability of the polylactic acid are effectively improved through molecular-level enhancement and an ionic cross-linking effect. The material can be widely applied to the fields of disposable tableware, food packaging films, degradable agricultural mulching films and the like.

The invention provides a 25-hydroxyvitamin D dissociation liquid, a detection kit and application. The 25-hydroxyvitamin D dissociation liquid comprises 10-100mM of a buffer solution with the pH value of 7.2-7.4, 0.1%-5% of long-chain alkane carboxylic acid and 0.1%-1% of an organic solvent. The 25-hydroxyvitamin D detection kit is prepared by developing a new 25-hydroxyvitamin D dissociation agent capable of replacing perfluorooctanoic acid and combining a double-antibody sandwich method, and has the characteristics of high accuracy, high sensitivity, good stability, simplicity and convenience in operation, high detection efficiency, low cost, safety, environmental friendliness and the like; and the method has relatively high economic value and social benefit.

The invention relates to the technical field of cefuroxime sodium medicines, and in particular provides a method for recycling a cefuroxime sodium mother liquor. On the basis of the prior art, a mother liquor nanofiltration impurity removal step and an organic solvent permeation steam recovery step are added, and cefuroxime acid and organic solvents acetone, ethyl acetate and dichloromethane in the cefuroxime sodium mother liquor can be effectively recycled and utilized, which not only solves the heavy environmental burden for production enterprises, but also brings potential considerable economic benefits to the production enterprises, and has great economic value and social value.

The invention relates to the technical field of pharmaceutical preparations, in particular to a docetaxel oral self-microemulsion composition and a preparation process thereof. The docetaxel oral self-microemulsion composition is prepared from docetaxel, an oil phase, a surfactant, a cosurfactant, a stabilizer and an antioxidant, the oil phase is caprylic / capric acid mono / diglyceride, medium chain triglyceride, caprylic acid propylene glycol ester or lauric acid propylene glycol ester. The docetaxel oral self-microemulsion composition provided by the invention has relatively high drug loading capacity, good physical and chemical stability and relatively high bioavailability, and is more suitable for clinical medication.

The invention provides a label adhesive tape without adhesive residues and a preparation method and application thereof, and belongs to the technical field of adhesive tapes, the preparation method comprises the following steps: uniformly mixing a waterborne polyurethane emulsion, functionalized polyurethane, a curing agent, a wetting dispersant, a thickening agent and a defoaming agent to obtain a polyurethane label adhesive; coating a polyurethane label adhesive on the base material layer, and curing to form a label adhesive layer; and compounding the protective layer on the label adhesive layer to obtain the label. Wherein the waterborne polyurethane emulsion is prepared by carrying out a reaction on polycarbonate ether polyol, 1, 5-naphthalene diisocyanate, tris (hydroxymethyl) aminomethane, glycerol, stannous octoate, triethylamine and water; the functionalized polyurethane is prepared by reacting sulfydryl grafted graphene, epoxy grafted polyurethane and triethylamine. The label adhesive tape prepared by the invention has good holding power, heat resistance and water resistance, and no adhesive residue exists.

The invention belongs to the technical field of cosmetics, and particularly relates to a water-in-oil-in-water three-phase coated microbead as well as a preparation method and application thereof. The water-in-oil-in-water three-phase coated microbead is of a spherical structure and sequentially comprises an outer water phase, an inner oil phase and an inner water phase from outside to inside, the outer water phase comprises sodium alginate, agarose, cyclodextrin, glycerin and other components, the inner oil phase comprises caprylic / capric triglyceride, grape seed oil, olive squalane, tocopherol and other components, and the inner water phase comprises sodium alginate, agarose, cyclodextrin, glycerin and other components. And the inner water phase comprises ampelopsis grossedentata extract, astragalus membranacus root extract and other components. According to the invention, an easily oxidized and unstable active matter is fully and firmly protected by adopting a droplet microfluidic coating technology, so that the active matter is free from external stimulation, active ingredients with different effects play multiple roles, and the composition has good anti-inflammatory, soothing and oil-controlling effects and can be applied to the field of cosmetics.

An oral suspension pharmaceutical composition is disclosed for water soluble salts of arylalkanoic acid (NSAID) drugs such as ibuprofen and naproxen. When mixed with glyceryl esters such as glyceryl caprate / caprylate and water, the resulting combination forms a “liquid scaffold” structure that reliably enables the suspension of significant quantities of said arylalkanoic acid drugs. For example, suspensions containing 25% w / w arylalkanoic acid may be obtained using the aforementioned combination. Suspensions comprising further pharmaceutically active agents, in addition to said arylalkanoic acids, may also be prepared. Also disclosed is a binary blend of glyceryl caprate / caprylate and the sodium salt of ibuprofen and a ternary blend of glyceryl caprate / caprylate and the potassium salt of ibuprofen.

The invention relates to the technical field of industrial microorganisms, and particularly discloses a yeast strain and application thereof. The invention provides clavipora lusitaniae YJHT233, which is obtained through space mutation breeding, can tolerate 9% of alcohol, can tolerate an acid environment with the lowest pH value of 2.5, can tolerate a 12% high NaCl system, a 55% high glucose system and a 44 DEG C high temperature environment, and has excellent ester production capacity. The strain is used for brewing rice-flavor liquor or yellow wine, the total content of ester substances in the obtained product is greatly increased, the content of main volatile ester substances such as ethyl acetate, ethyl butyrate, isoamyl acetate, ethyl caprylate and ethyl lactate is remarkably increased, the whole flavor is coordinated and pleasant, and the fruit fragrance is rich and rich in layers.

The invention belongs to the technical field of cosmetics, and discloses micro-emulsion essence water containing ceramide and a preparation method of the micro-emulsion essence water. The micro-emulsion essence containing ceramide is prepared from the following components: an emulsifier, a humectant, polypeptide, small molecular grease and water, the emulsifying agent comprises polyglycerol-10 oleate, the emulsifying agent does not contain a PEG and / or PPG structure, the humectant comprises glycerol and ceramide, and the small molecule grease comprises at least one of tridecane, undecane, isononyl isononanoate, propyl heptyl octoate, coconut oil alcohol-octoate / caprate, dicapryl carbonate and dioctyl ether. The micro-emulsion essence water containing ceramide has excellent stability, low viscosity, refreshing texture which is common to water and fine skin feeling, and also has excellent moisturizing and tightening effects.

The invention belongs to the technical field of microbial fermentation, and particularly relates to a new enterobacter rorrhizae strain as well as a separation and screening method and application thereof. In order to enrich microbial resources for producing pyrazine substances through metabolism in the white spirit industry, an enterobacter rorrhizae strain is separated and screened from a mixture of yeast for making hard liquor and fermented grains, and the preservation number is CGMCC No.33262. The strain has good tolerance to pH, salt and alcohol, and can adapt to the growth environment in the white spirit production process; and various pyrazine substances represented by tetramethylpyrazine can be produced. Besides, the strain has strong adaptability to fermented grains, the yield of tetramethylpyrazine is high in a culture medium taking bran, wheat and five grains as the fermented grains, and meanwhile, various flavor substances such as ethyl acetate, ethyl hexanoate, ethyl caprylate, 2, 3-butanediol, guaiacol and 4-vinyl guaiacol can be produced. Therefore, the enterobacter rorrhizae disclosed by the invention can be widely used for brewing white spirit.

The invention belongs to the technical field of veterinary drug preparations, and particularly relates to a compound external ointment for treating parasites of dogs and cats and skin tinea and a preparation method, the compound external ointment comprises the following components by mass percent: 2%-12% of selamectin, 3%-20% of imidacloprid, 0.5%-2% of terbinafine hydrochloride, 2%-12% of dipropylene glycol monomethyl ether, 10%-50% of isopropanol, 9%-45% of polyethylene glycol 400 and the balance of water. The adhesive is prepared from, by weight, 9%-45% of polyethylene glycol 3350, 5%-15% of caprylic / capric polyethylene glycol glyceride, 1%-8% of oleyl alcohol, 0.5%-5% of dimeticone, 0.01%-0.1% of butylated hydroxytoluene and 1%-5% of cassava starch polymethylsesquioxane. The preparation method comprises the following steps: uniformly stirring the selamectin, the imidacloprid, the terbinafine hydrochloride and the mixed solvent, then mixing with the matrix (the polyethylene glycol 400 and the polyethylene glycol 3350 are heated and uniformly mixed in advance), the emulsifier and other components, and homogenizing. The compound selamectin ointment prepared by the invention can realize accurate administration at the edge of the auricle of an animal, and not only can ensure that the medicine is fully absorbed, but also can improve the compliance of animal administration; the composition not only can expel parasites in a broad spectrum, but also has broad-spectrum antifungal activity, and can prevent and treat a plurality of skin diseases of pets.

The invention belongs to the technical field of cosmetics, and particularly relates to a skin care composition with repairing and anti-aging effects. The skin care composition is prepared from the following components in parts by weight: 2.5 to 4 parts of common wheat extract, 0.1 to 1 part of phospholipid, 1 to 2 parts of squalane, 2.5 to 4 parts of caprylic / capric triglyceride, 0.5 to 1.5 parts of glycolipid, 0.01 to 0.5 part of phytosphingosine, 0.001 to 0.1 part of ceramide NS / ceramide NG, 0.05 to 3 parts of radix gentianae extract, 0.1 to 2 parts of crithmum maritimum extract and 0.01 to 0.5 part of myrothamnus flabellifolia leaf / stem extract. 0.01 to 1.0 part of rose extract and 0.01 to 0.8 part of chrysanthemum extract. The skin care composition disclosed by the invention has repairing and anti-aging effects and can be used for preparing sebum bionic cosmetics.

The invention discloses allicin oleogel as well as a preparation method and application thereof, and belongs to the technical field of medicines. The allicin oleogel is prepared from the following raw materials: allicin, an oil phase, a gelator and a surfactant, the gelator comprises beeswax and / or fruit wax; the surfactant comprises one or more of caprylic / capric polyethylene glycol glyceride, Tween 20 and polyglycerol fatty acid ester. The gel factor forms oil gel through crystal self-assembly, allicin is solidified and intercepted in the oil gel, the gel factor is optimized, and a surfactant is used in a matched manner, so that a release behavior similar to that of a mixed solution of free allicin and an oil phase can be obtained, and the transdermal release rate is improved. The allicin oil gel can effectively entrap allicin, cover the peculiar smell of the allicin and improve the stability of the allicin, and through abdominal transdermal administration, the medicine accumulation amount in subcutaneous adipose tissues is remarkably increased, and the treatment effect on obesity and complications thereof can be improved.

A microbial composite reagent, a preparation method thereof, and a method for removing perfluorooctanoic acid are disclosed. The preparation method of the microbial composite reagent includes steps of: preparing a glucose-based carbonaceous material by pyrolyzing glucose at 400° C. to 1000° C. for at least 0.5 hours under a protective atmosphere; mixing perfluorooctanoic acid-contaminated soil with a basal medium, molasses, a vitamin B, and water, and subjecting the mixture to microbial acclimation under an anaerobic condition to obtain an acclimated microorganism solution; subjecting the glucose-based carbonaceous material to microbial loading by anaerobically mixing the glucose-based carbonaceous material with the acclimated microorganism solution, thereby obtaining the microbial composite reagent.

The invention discloses a method and a system for producing high-purity medium-chain fatty acid (MCFA) based on waste molasses two-stage regulation fermentation. Comprising the following steps: (1) diluting waste molasses, then adding a compound enzyme agent of pectinase, beta-glucanase and cellulase, and coupling microwave to assist treatment; (2) inoculating the pretreated waste molasses with a composite flora containing a clostridium kluyveri mutant strain and a Megasphaera elsdeni engineering bacterium, and carrying out a fermentation treatment on the waste molasses, wherein the composite flora contains the clostridium kluyveri mutant strain and the Megasphaera elsdeni engineering bacterium; (3) sequentially performing two-stage dynamic regulation and control fermentation on the waste molasses inoculated with the composite flora through a pH-stat control strategy to realize efficient conversion from butyric acid to hexanoic acid / octanoic acid; and (4) a hydrophobic hollow fiber membrane module is adopted to realize on-line removal of the product, and the inhibition effect of the product is relieved. According to the technology, the yield of the MCFA produced from the waste molasses reaches 0.45 g / g COD, the cost is reduced by 68% compared with that of a traditional substrate, and a new way is provided for recycling of sugar manufacturing waste.

The present invention relates to detergents and cleaning compositions that comprise a surfactant, an anti-redeposition agent, and an effective amount of 1,2-heptanediol and / or 2,3-heptanediol or a specific type of anti-redeposition boosting agent, such as alkanediols, glyceryl caprylate, 4-hydroxyacetophenone, ethyl hexyl glycerin or tropolone, and the use of said detergents and cleaning compositions for the preparation of a detergent and cleaning product for household, institutional and industrial application. Furthermore, the present invention relates to a method of treating a stained and / or soiled substrate, using the detergents and cleaning compositions according to the present invention. Additionally, the present invention relates to the use of 1,2-heptanediol and / or 2,3-heptanediol or of specific substances as defined herein for boosting the activity of an anti-redeposition agent in a detergent and cleaning composition and / or for improving cleaning performance of a detergent and cleaning composition. Moreover, the present invention relates to a method of boosting the activity of an anti-redeposition agent in a detergent and cleaning composition and / or of improving cleaning performance of a detergent and cleaning composition by adding an effective amount of 1,2-heptanediol and / or 2,3-heptanediol or of specific anti-redeposition agents, such as alkanediols, glyceryl caprylate, 4-hydroxyacetophenone, ethyl hexyl glycerin or tropolone to said detergent and cleaning composition. Finally, the present invention relates to the use of 1,2-heptanediol, 2,3-heptanediol or a mixture comprising 1,2-heptanediol and 2,3-heptanediol or at least one anti-redeposition boosting agent, such as alkanediols, glyceryl caprylate, 4-hydroxyacetophenone, ethyl hexyl glycerin or tropolone as anti-redeposition agent.

The present invention relates to a preparation method and application of a supramolecular aggregate surfactant, and belongs to the field of supramolecular coordination chemistry, surface modification engineering and hydrophobic coating technology. In the present invention, 4-hydroxypyridine-2,6-dicarboxylic acid and malonic acid prepare an adhesive ligand, and with the help of the coordination of the carboxyl structure and lanthanum ions on 4-hydroxypyridine-2,6-dicarboxylic acid and perfluorooctanoic acid, a supramolecular aggregate in a nano-aggregated state is obtained, which is self-assembled into a supramolecular aggregate surfactant. The active agent can solubilize fluoride and can also be applied in the field of hydrophobic coatings. The coating has the characteristics of imitating lotus leaf structure and hydrophobic wax, and has good hydrophobic properties.

The invention belongs to the technical field of synthetic ester, and particularly relates to a preparation method of fatty acid pentaerythritol ester base oil, which comprises the following steps: carrying out esterification reaction on pentaerythritol and fatty acid in the presence of a catalyst and a color retention agent, and carrying out post-treatment to obtain the fatty acid pentaerythritol ester base oil, the catalyst comprises at least one of stannous octoate, stannous oxalate, stannous oxide, tetrabutyl titanate, isopropyl titanate and sodium hydrogen sulfate; the color retention agent comprises at least one of sodium hypophosphite, hypophosphorous acid, activated carbon and sodium sulfite. The color retention agent sodium hypophosphite is matched with the specific catalyst such as stannous oxalate, so that the petroleum color number of the produced fatty acid pentaerythritol ester base oil is smaller, and meanwhile, the esterification reaction time is shorter.

The invention relates to the technical field of cosmetics, in particular to preparation and application of a cyclodextrin-coated azelaic acid oil-control skin-care product. Comprising the following steps: S1, adding deionized water into a mixer, adding a cyclodextrin-azelaic acid inclusion compound, nicotinamide and allantoin, mixing to obtain a water phase, mixing glycerol, caprylic / capric triglyceride, polydimethylsiloxane, polysorbate-80 and tocopheryl acetate to obtain an oil phase, slowly adding the oil phase into the water phase, and shearing and emulsifying to obtain a nanoemulsion; and S2, cooling the nano-emulsion, adding carbomer while stirring, continuously cooling to room temperature, sequentially adding phenoxyethanol, ferulic acid, menthol and essence, adjusting the pH value of the emulsion with triethanolamine, homogenizing, defoaming, disinfecting and filling. By adjusting the proportion of the components in the formula, the skin feeling of the product can be further optimized, so that the product is more comfortable and not greasy, and a lasting oil control effect is provided.

The invention relates to the field of cosmetics, and discloses ceramide liposome and application thereof.The ceramide liposome is prepared from, by mass, 1.5-3 parts of ceramide NP, 1-3 parts of octyldodecanol, 0.5-2 parts of caprylic / capric triglyceride, 11-18 parts of hydrogenated lecithin, 2-6 parts of sucrose stearate, 3-7 parts of polyglycerol-10 oleate and 25-35 parts of glycerinum, and the balance is water. 0.5-8 parts of 1, 2-pentanediol, and the balance of water. The ceramide liposome provided by the invention has good stability at least at 40 DEG C, is not easy to cause lactic acid pricking pain and allergy after being smeared on skin, and can be used for sensitive skin; the skin care product can reduce skin transdermal moisture loss, maintain skin cutin moisture, reduce skin heme content, improve skin gloss, relieve skin dryness, relieve skin redness and improve skin fineness, and has the effects of moisturizing, repairing and relieving.

The application discloses a soluble microneedle composition for transdermal delivery of polypeptides and application thereof. The soluble microneedle composition comprises a first composition and a second composition; wherein the first composition comprises the following components in mass percentage: 20-60% polypeptides, 0.5-20% capryol 98, 10-40% first biocompatible polymer material and 0.5-20% first surfactant; the second composition comprises the following components in mass percentage: 98-99.75% second biocompatible polymer material and 0.25-2% second surfactant. The microneedle composition is used in the microneedle, and the problems of low transdermal efficiency and poor stability of polypeptides are solved.