8 results about "Butylated hydroxytoluene" patented technology

This invention relates to the field of organic synthesis technology, specifically to a highly efficient and stable Grignard preparation and its green preparation method. By weight, it comprises 8-18 parts of a magnesium source, 40-92 parts of a halogenated hydrocarbon, 150-200 parts of a green solvent, 15-20 parts of ethylene glycol dimethyl ether, and 2.3-3.2 parts of a synergistic stabilizer. The green solvent is 2-methyltetrahydrofuran, or a composite solvent with a weight ratio of 2-methyltetrahydrofuran:methyl tert-butyl ether of 150-160:40-50. The synergistic stabilizer is composed of 1.5-2.0 parts of N,N,N',N'-tetramethylethylenediamine and 0.8-1.2 parts of butylated hydroxytoluene, or composed of 1.5-2.0 parts of N,N,N',N'-tetramethylethylenediamine and 1.0 part of phenothiazine. This invention uses a green solvent system to replace traditional toxic and harmful solvents, and combines it with a solvent recovery process to achieve solvent recycling, which greatly reduces waste emissions and makes the production process safer and more environmentally friendly, in line with the development direction of green chemical industry.

The invention relates to a pharmaceutical dosage form for oral administration comprising (i) an intragranular phase, which comprises Sertraline or a physiologically acceptable salt thereof; one or more intragranular fillers (preferably selected from one or more sugar alcohols or sugars; preferably mannitol or lactose, more preferably mannitol); one or more intragranular antioxidants (preferably selected from butylated hydroxytoluene (BHT), butylated hydroxy anisole (BHA), tocopherol or derivatives thereof, ascorbic acid or derivatives thereof, sodium metabisulphite, propyl gallate, sodium thiosulphate, or any combination thereof, more preferably ascorbic acid); (ii) an extragranular phase, which comprises one or more extragranular fillers (preferably mannitol, microcrystalline cellulose, lactose, or any combination thereof); and (iii) optionally, a film coating. The invention further relates to a process for manufacture by wet granulation, wherein the antioxidant is preferably dissolved in the granulation liquid.

This invention provides a method for extracting astaxanthin from Haematococcus pluvialis and its application. The method includes the following steps: S1. Raw material pretreatment; S2. Enzymatic hydrolysis with a complex enzyme; S3. Solubilization with a surfactant; S4. Adsorption by iron(III) oxide-cellulose porous microspheres; S5. Magnetic separation and washing; S6. Astaxanthin elution and microsphere recovery; S7. Concentration and drying. This invention utilizes a complex enzyme consisting of cellulase, alginate lyase, and mannanase to synergistically hydrolyze the multilayer polysaccharide structure of thick-walled spores of Haematococcus pluvialis, thereby fully releasing astaxanthin. Furthermore, iron(III) oxide-cellulose porous microspheres with benzyl and octyl surface modifications are used for highly selective adsorption of astaxanthin, combined with magnetic separation technology, thus improving the astaxanthin yield. The extraction process of this invention is carried out under medium-low temperature conditions, and butylated hydroxytoluene is added to the eluent, effectively avoiding thermal degradation, photolysis, and oxidation of astaxanthin, resulting in a high retention rate of antioxidant activity in the obtained astaxanthin.

This invention discloses a long-acting, sustained-release Artemisia argyi compound essential oil and its preparation method, relating to the field of plant essential oil technology. The Artemisia argyi compound essential oil comprises the following raw material components: by weight, 92-106 parts of plant oil, 0.3-0.5 parts of vanillyl butyl ether, 0.05-0.15 parts of butylated hydroxytoluene, and 3-5 parts of a sustained-release agent; the plant oil is composed of grape seed oil, bitter orange blossom oil, and Artemisia argyi leaf oil; the plant oil is composed of grape seed oil, bitter orange blossom oil, and Artemisia argyi leaf oil in a mass ratio of (80-90):(7-9):(5-7). The Artemisia argyi compound essential oil prepared by this application has a long-acting, sustained-release function, effectively improving the transdermal absorption rate and antioxidant properties of the essential oil.

This invention belongs to the field of pharmaceutical preparations, and particularly relates to a dimethicone emulsion and its preparation method. The preparation method provided by this invention includes the following steps: a) grinding and mixing dimethicone and silica at 100-140°C to obtain an oil phase mixture; b) mixing sodium saccharin, ethylparaben, and water, and then mixing with sodium carboxymethyl cellulose to obtain an aqueous phase mixture; c) mixing the oil phase mixture, polysorbate 80, and sorbitan oleate, and then mixing with a portion of the aqueous phase mixture, followed by homogenization to obtain a primary emulsion; d) mixing the remaining aqueous phase mixture, an ethanol solution of butylated hydroxytoluene, and a fragrance, and then mixing with the primary emulsion, finally adding water to make up to a fixed volume and mixing to obtain the dimethicone emulsion. The preparation method provided by this invention has a short production cycle and high production efficiency, and the resulting dimethicone emulsion product has excellent defoaming ability and quality stability.

This invention discloses a method for inhibiting the oxidation and discoloration of watermelon-flavored nicotine bags, addressing the technical challenge of easy oxidation and discoloration of unsaturated aldehydes, such as melon aldehyde, and aroma deterioration under conditions of high humidity, high pH, ​​and coexistence of metal ions. The method involves dissolving butylated hydroxytoluene (BHT) in watermelon flavoring to prepare watermelon flavoring microcapsules, which are then compounded with citric acid. The core material of the nicotine bag is used as the core material to prepare core material microcapsules. The watermelon flavoring microcapsules containing the composite antioxidant, the core material microcapsules, plant fiber fillers, and other auxiliary additives are mixed evenly, filled into a breathable bag, and sealed to obtain the finished product. This invention effectively inhibits the oxidation and discoloration of watermelon flavoring through the synergistic antioxidant effect of BHT and citric acid, combined with the physical isolation protection of double microcapsules, thus extending the shelf life of nicotine bags. Furthermore, the process is simple, compatible with existing production lines, and highly practical.

This invention provides a method for determining impurities in ipratropium bromide inhalation solution, belonging to the field of pharmaceutical detection technology. The method involves preparing a test solution from the ipratropium bromide solution, using a mixture of ammonium acetate buffer and acetonitrile as mobile phase A and an acetonitrile mixture as mobile phase B, followed by isocratic elution at a volume ratio of 30:70 and high-performance liquid chromatography (HPLC) to detect impurities sulfur and butylated hydroxytoluene (BHT) in the ipratropium bromide solution. This invention employs HPLC, resulting in more accurate and consistent results with theoretical predictions. Furthermore, the method exhibits satisfactory recovery and specificity, high accuracy, and high precision. It provides a novel and accurate method for determining sulfur (S) and BHT in ipratropium bromide inhalation solution, enabling better quality control and evaluation of ipratropium bromide inhalation solutions.