64 results about "Butylated hydroxytoluene" patented technology

The invention relates to the technical field of disinfectant preparation, in particular to a composite phenol disinfectant and a preparation method thereof.The preparation method comprises the following steps that S1, a solution A is prepared; s2, dissolving butylated hydroxytoluene and sodium thiosulfate in an organic solvent to obtain a solution B; s3, mixing crude phenol, organic acid, cyclohexane and a surfactant with water, and uniformly stirring to obtain a solution C; s4, mixing the solution A, the solution B and the solution C, and adding carboxymethyl tallow-based poly (propylamine) sodium and a preservative to obtain a compound phenol disinfectant; and S5, adjusting the pH value of the mixed composite phenol disinfectant to finally obtain a finished product of the composite phenol disinfectant. By optimizing the formula and innovating the preparation process, the stability and durability of the disinfection effect are remarkably improved, the problems of effect fluctuation and poor stability of a disinfectant in the prior art are solved, and the requirements of the livestock and poultry breeding industry for an efficient and stable disinfectant are met.

The invention provides a preparation method of a non-bulking waterproof moisture-permeable TPU film, and belongs to the technical field of TPU film preparation, and the preparation method of the non-bulking waterproof moisture-permeable TPU film comprises the following steps: stirring raw materials by a high-speed mixer for mechanical mixing; carrying out chemical reaction on the raw material, a divinylbenzene-ethyl acrylate-acrylamide copolymer and butylated hydroxytoluene, and adding tetrahydrofuran to adjust the viscosity of a reaction system, so as to obtain a TPU film material; heating, pressurizing and extruding the mixture through a screw extruder to form a film, plasticizing TPU particles into a semi-finished product, and filtering impurities and re-plasticizing on a filter of calendering equipment; carrying out annealing treatment, cooling in cold water, and pulling out the cooled TPU stretching film from a demolding opening of the demolding machine; the problems that an existing TPU film is poor in preparation size stability and prone to deformation can be solved.

The invention belongs to the field of renewable resource environment-friendly materials, and particularly relates to a method for preparing a high-performance sound insulation material by using solid waste plastics, a synthesis method of the sound insulation material, and an action principle and application of a modified material. According to the present invention, the formula is synergistic, the sound insulation, the mechanical property and the processing property are balanced, the tensile strength is more than 25 MPa, the sound insulation is excellent in the multi-frequency band, the processing is smooth, and the yield is high, which is far better than the specific components of the brand A product of the traditional recycled plastic sound insulation material: the recycled polyethylene (PE) and the polypropylene (PP) are mainly adopted, and the ratio of the recycled polyethylene (PE) to the polypropylene (PP) is about 3: 2. About 10% calcium carbonate is added as a filler to increase the hardness and weight of the material. Meanwhile, a small amount of antioxidant (about 0.5%), such as butylated hydroxytoluene (BHT), is contained and is used for delaying the aging speed of the material.

The application provides a water-permeable asphalt composition and a preparation method thereof, and the composition comprises the following components and mass fractions: 22-28 parts of base asphalt, 65-75 parts of modified composite aggregate, 3-4 parts of interface reinforcing agent, 1-2 parts of nano anti-aging agent, and 0.3-0.5 parts of antioxidant dibutyl hydroxytoluene, wherein the modified composite aggregate is compounded by basalt coarse aggregate, ceramsite fine aggregate and recycled glass microbeads at a mass ratio of 5-7:3-5:1. Through the synergistic effect of the multistage aggregate compounding system, the bio-based interface reinforcing technology and the nano drug-loaded anti-aging process, the mechanical strength and durability are significantly improved while the high water permeability is maintained, and the low-temperature modification and solid waste recycling technology are used to realize the environment-friendly and low-consumption production.

Dibutylhydroxytoluene, which is blended into ophthalmic solutions as an antioxidant, decreases in content in the ophthalmic solution due to its volatility, adsorption, decomposition, etc. By blending dibutylhydroxytoluene with one or more thickeners selected from the group consisting of xanthan gum, gelatin, and carrageenan, an ophthalmic solution is provided in which the decrease in the dibutylhydroxytoluene content is suppressed.

This invention relates to the field of organic synthesis technology, specifically to a highly efficient and stable Grignard preparation and its green preparation method. By weight, it comprises 8-18 parts of a magnesium source, 40-92 parts of a halogenated hydrocarbon, 150-200 parts of a green solvent, 15-20 parts of ethylene glycol dimethyl ether, and 2.3-3.2 parts of a synergistic stabilizer. The green solvent is 2-methyltetrahydrofuran, or a composite solvent with a weight ratio of 2-methyltetrahydrofuran:methyl tert-butyl ether of 150-160:40-50. The synergistic stabilizer is composed of 1.5-2.0 parts of N,N,N',N'-tetramethylethylenediamine and 0.8-1.2 parts of butylated hydroxytoluene, or composed of 1.5-2.0 parts of N,N,N',N'-tetramethylethylenediamine and 1.0 part of phenothiazine. This invention uses a green solvent system to replace traditional toxic and harmful solvents, and combines it with a solvent recovery process to achieve solvent recycling, which greatly reduces waste emissions and makes the production process safer and more environmentally friendly, in line with the development direction of green chemical industry.

The invention belongs to the technical field of transdermal patches, and relates to a transdermal patch for improving the bioavailability of estradiol and a preparation method of the transdermal patch. The transdermal patch is prepared from the following components in percentage by weight: 5 to 21 percent of estradiol, 8 to 15 percent of polymer matrix, 0.5 to 1.5 percent of butylated hydroxytoluene, 10 to 15 percent of hydrogenated rosin glyceride, 2 to 5 percent of penetration enhancer, 3 to 8 percent of plasticizer and 25 to 35 percent of solvent. According to the transdermal patch disclosed by the invention, continuous and stable release of a medicine is realized, the transdermal absorption rate of estradiol is improved, so that the bioavailability is improved, the treatment effect is further improved, and meanwhile, the transdermal patch disclosed by the invention can also avoid a first-pass effect of the liver and reduce side effects; the transdermal drug delivery system is convenient to use, and the compliance of a patient is improved.

The invention relates to the technical field of lithium ion batteries, and discloses positive electrode slurry, a lithium ion battery and an electric device. Wherein the positive electrode slurry comprises a positive electrode active material, a positive electrode conductive agent and a positive electrode binder, the positive electrode binder comprises a polyvinylidene fluoride-hexafluoropropylene copolymer and an in-situ free radical inhibitor, the polyvinylidene fluoride-hexafluoropropylene copolymer is prepared from 1, 1-difluoroethylene and hexafluoropropylene through a high-pressure emulsion polymerization method, and the in-situ free radical inhibitor is prepared from 1, 1-difluoropropylene and hexafluoropropylene through a high-pressure emulsion polymerization method. The in-situ free radical inhibitor is prepared from one or more of 2, 2, 6, 6-tetramethylpiperidine oxygen free radicals, butylated hydroxytoluene and tert-butylphenol. According to the invention, a water-based positive electrode binder system with anti-gelling capability is constructed, and a dual mechanism that PVDF-HFP and TEMPO synergistically regulate and control polymer chain segment crystallization behavior and free radical crosslinking reaction is realized. Therefore, the rebound of viscosity can be remarkably reduced, and the rate capability and cycle life of the battery are improved.

The present disclosure includes chewing gum base compositions and related methods of use and preparation thereof. For example, the present disclosure includes a chewing gum base composition comprising from about 25% to about 50% by weight of a natural rubber composition, from about 20% to about 35% by weight of a resin, from about 15% to about 25% by weight of a filler, from about 15% to about 20% by weight of a softener, from about 15% to about 20% by weight of a plasticizer, and from about 2% to about 10% by weight of an emulsifier. The natural rubber composition may include at least 99% by weight of edible deproteinized natural rubber, and the edible stabilizer includes an antioxidant selected from the group consisting of butylated hydroxytoluene (BHT), tocopherol, or a combination thereof.

This invention discloses an inorganic stone with a granite-like texture and its preparation method, belonging to the field of building materials technology. The modified reinforcing fibers of this invention have higher surface active sites, effectively enhancing the interfacial bonding force between the modified reinforcing fibers and the inorganic matrix. By compounding polyvinyl alcohol fibers, silicon carbide fibers, and basalt fibers of different grades, a multi-layered, multi-dimensional spatial network structure is constructed in the matrix, working synergistically to achieve significant reinforcement. This invention uses butylated hydroxytoluene and nano-titanium dioxide to modify styrene-butadiene emulsion, improving the compatibility of the modified styrene-butadiene emulsion with inorganic hydration products. The organic-inorganic interpenetrating network structure formed after curing further enhances the toughness and impermeability of the inorganic stone. Overall, it yields a dense, smooth, low-water-absorption, high-gloss, and mechanically excellent granite-like inorganic stone, meeting the requirements for high-performance environmentally friendly imitation stone materials.

The invention relates to the technical field of veterinary medicines, in particular to a vitamin ADE injection for cattle and a preparation method thereof. Every 10 L of the vitamin ADE injection for the cattle is prepared from the following components: 500 to 600 g of vitamin A palmitate, 2 to 3 g of vitamin D3, 2800 to 3200 g of vitamin E acetate, 10 to 20 g of butylated hydroxytoluene, 1800 to 2200 g of absolute ethyl alcohol, 180 to 220 g of analgesic, 250 to 350 g of solubilizer, 150 to 250 g of stable synergist and the balance of isopropyl myristate. According to the invention, hydrogenated palm oil glyceride, ethylene oxide, succinic anhydride, ascorbyl palmitate and the like are used as raw materials, and the stable synergist with the following effects is prepared through related chemical reactions, and the prepared stable synergist integrates the functions of solubilization, oxidation resistance and stimulation reduction; as a raw material of the injection, the oxidation resistance and the stability of the injection are effectively improved; the injection prepared by the invention is clear and transparent, has excellent stability, can effectively relieve injection pain and tissue stimulation, and remarkably improves the safety, stability and clinical applicability of the injection.

This invention discloses a compound additive and its application in removing corrosive sulfur from mineral insulating oil, relating to the field of insulating oil additives. It includes a first inhibitor, a second inhibitor, a first antioxidant, and a second antioxidant. The first inhibitor is a benzotriazole derivative, and the second inhibitor is a thiadiazole derivative and / or methylbenzotriazole. The first antioxidant is pyrogallol, and the second antioxidant is butylated hydroxytoluene and / or tert-butylhydroquinone. This additive uses a compound inhibitor and a compound antioxidant. When applied to mineral insulating oil, the synergistic effect of the compound inhibitor improves the insulating oil's resistance to corrosive sulfur. Simultaneously, the compound antioxidant and compound inhibitor are balanced to maximize the insulating oil's oxidation resistance, providing continuous and efficient protection for mineral insulating oil in actual operation, resulting in excellent physical and electrical properties.

The present application relates to the technical field of lubricating oil, and discloses energy-saving and wear-reducing low-volatility lubricating oil for diesel vehicles and a preparation method thereof, which comprises the following raw materials in parts by mass: poly-α-olefin copolymer 40-50 parts, benzoic acid 1.5-2 parts, alkyl alcohol amide 1-1.5 parts, dibutyl hydroxytoluene 1-1.5 parts, composite additive 2-3 parts, polymethyl methacrylate 1-2 parts, and bis(hexafluoroisopropyl) phosphate 1-2 parts. The energy-saving and wear-reducing low-volatility lubricating oil formed by mixing the poly-α-olefin copolymer, benzoic acid, alkyl alcohol amide, dibutyl hydroxytoluene, composite additive, polymethyl methacrylate and bis(hexafluoroisopropyl) phosphate has high wear-resistant lubricating performance, and the surface of the composite additive contains a copolymer of triethylene glycol divinyl ether and dodecene, so that the composite additive can be uniformly dispersed in the lubricating oil system to play the wear-resistant lubricating performance.

The invention discloses soothing essential oil based on wormwood essential oil and a processing technology thereof, and relates to the technical field of daily chemical industry, and the processing technology comprises the following steps: adding a chitosan quaternary ammonium salt solution into a peach gum solution, heating, stirring and uniformly mixing, adding an Arabic gum solution and uniformly mixing, adjusting the pH value to 7 with glacial acetic acid, adding emulsified compound essential oil and uniformly mixing, cooling, and carrying out gradient freeze drying to obtain the soothing essential oil. Compound essential oil microcapsule powder is obtained; the preparation method comprises the following steps: adding egg yolk lecithin and cholesterol into absolute ethyl alcohol, carrying out rotary evaporation and vacuum drying, then adding a phosphate buffer solution containing Ectoine, carrying out ultrasonic uniform mixing, filtering, adding trehalose, and carrying out gradient freeze drying to obtain Ectoine liposome freeze-dried powder; adding the grape seed oil and the meadowfoam seed oil into a container, preheating and uniformly mixing, adding the compound essential oil microcapsule powder, the Ectoine liposome freeze-dried powder, the dimethylsilanol hyaluronate, the squalane, the butylated hydroxytoluene and the vanillyl butyl ether, and stirring until the materials are completely uniform, so as to obtain the wormwood soothing essential oil.

The invention discloses a wear-resistant non-slip mat and a preparation method thereof, and relates to the technical field of non-slip mats. The wear-resistant non-slip mat is prepared from the following raw materials in parts by weight: 50 to 70 parts of natural rubber, 15 to 25 parts of butadiene styrene rubber, 10 to 20 parts of chlorinated polyethylene rubber, 8 to 15 parts of quartz sand, 8 to 12 parts of modified glass fiber, 5 to 8 parts of rapeseed oil, 2 to 3 parts of azodicarbonamide, 1 to 2 parts of sulfur, 1 to 2 parts of 2, 6-butylated hydroxytoluene, 0.5 to 1 part of modified graphite powder, 0.3 to 0.8 part of nano titanium dioxide and 2 to 4 parts of rosin resin. The wear-resistant non-slip mat has remarkable advantages. The raw materials are scientifically matched, natural rubber and other base materials guarantee basic performance, and quartz sand and other materials enhance wear resistance and skid resistance. The components are subjected to special pretreatment, such as quartz sand hydrochloric acid soaking and azodicarbonamide activation, so that the compatibility and binding force are improved. The two-stage vulcanization and other steps ensure that the product quality is stable, and the comprehensive performance is good.

The invention relates to the technical field of preparation of medical rubber gloves, and provides a medical rubber glove and a preparation method thereof. The medical rubber glove is prepared from the following raw materials in parts by weight: 80 to 90 parts of modified natural latex, 1 to 2 parts of zinc oxide, 1 to 2 parts of sulfur, 1 to 2 parts of accelerant, 1 to 2 parts of modified BHT (butylated hydroxytoluene) and 1 to 2 parts of polymer coating. By means of the technical scheme, the problem that rubber is prone to tensile fracture in the prior art is solved.

The application discloses a non-polyrolone drop and a preparation method thereof, relates to the technical field of pharmaceutical preparations, and solves the technical problems of poor stability, obvious increase of impurities during long-term storage and the like of the existing non-polyrolone drop.The non-polyrolone drop contains the following raw material components per 1000ml: 0.1-1g of ammonium bromide, 100g of non-polyrolone, 10-12g of an antioxidant, 10-12g of a solubilizer, 100-150ml of a stabilizer, and the balance of purified water.The antioxidant is at least one of dibutyl hydroxyl toluene and p-hydroxy tertiary butyl anisole, the solubilizer is polyvidone K17, and the stabilizer is diethylene glycol monoethyl ether.The stability of the drop can be greatly improved by adding the component ammonium bromide in the non-polyrolone drop, and the quality stability of the non-polyrolone drop prepared by the application is obviously improved.

The invention relates to the technical field of regenerated rubber production, in particular to heat-resistant regenerated rubber. The composite material is prepared from the following components in parts by weight: 60-80 parts of waste rubber powder, 15-30 parts of ethylene propylene diene monomer, 5-10 parts of silane modified graphene / nano silicon dioxide composite filler, 3-8 parts of N-phenylmaleimide-glycidyl methacrylate copolymer heat-resistant agent, 5-12 parts of polyphosphazene elastomer, 1-3 parts of vulcanizing agent, 0.5-2 parts of accelerant, 1-3 parts of active agent and 1-3 parts of anti-aging agent. The waste rubber powder is subjected to ozone-microwave synergistic treatment, and the composite filler is modified through a silane coupling agent; the vulcanizing agent is a ternary compound of dicumyl peroxide, sulfur and 2-mercaptobenzothiazole, and the anti-aging agent is a compound of 4010NA, RD and 2, 6-butylated hydroxytoluene. Through multi-component collaborative design and process optimization, the mechanical property, heat resistance, heat conductivity and aging resistance of the material are improved, the problems that traditional regenerated rubber is unbalanced in rigidity and toughness, poor in heat resistance and the like are solved, and the comprehensive performance is excellent.

The invention discloses a high-weather-resistant and water-resistant modified high-temperature-resistant adhesive, and belongs to the technical field of organic silicon adhesives. The preparation method comprises the following steps: mixing and stirring polysiloxane, polyvinyl acid ester, modified gas silicon, modified boron nitride, fluorine micro powder, oligomeric silsesquioxane, modified carbon nanotubes, carboxyl glycerol, zinc stearate, graphene, metal oxide, halloysite, butylated hydroxytoluene and dicyandiamide to obtain a component A; mixing polysilazane, a deoximation curing agent, a water removal agent, an adhesion promoter, cyclohexanone peroxide, a plasticizer and dithiobis (disilazane) phenol, and uniformly stirring to obtain a component B; and mixing the component A and the component B to obtain the double-component high-weather-resistant water-resistant modified high-temperature-resistant adhesive. The high-temperature-resistant adhesive can effectively solve the problems that an existing adhesive is insufficient in flexibility and poor in moisture resistance and thermal aging resistance, preparation is easy and convenient, and the obtained high-temperature-resistant adhesive has high flexibility, good moisture resistance, corrosion resistance, bacteriostasis, oil resistance and aging resistance, good stability and long storage life.

The invention relates to a pharmaceutical dosage form for oral administration comprising (i) an intragranular phase, which comprises Sertraline or a physiologically acceptable salt thereof; one or more intragranular fillers (preferably selected from one or more sugar alcohols or sugars; preferably mannitol or lactose, more preferably mannitol); one or more intragranular antioxidants (preferably selected from butylated hydroxytoluene (BHT), butylated hydroxy anisole (BHA), tocopherol or derivatives thereof, ascorbic acid or derivatives thereof, sodium metabisulphite, propyl gallate, sodium thiosulphate, or any combination thereof, more preferably ascorbic acid); (ii) an extragranular phase, which comprises one or more extragranular fillers (preferably mannitol, microcrystalline cellulose, lactose, or any combination thereof); and (iii) optionally, a film coating. The invention further relates to a process for manufacture by wet granulation, wherein the antioxidant is preferably dissolved in the granulation liquid.

The application discloses a whitening and anti-wrinkle composition and a preparation method and an eye cream thereof, the eye cream contains the following raw materials: plant extract, petrolatum, polyglyceryl-2-diisostearate, dipropylene glycol, camosine, octyldodecanol lauroyl glutamate, caffeine, vitamin E, carbomer, butylated hydroxytoluene, palmitoyl tripeptide-1 and water. The plant extract contains sapindus peruviana peel extract, tea leaf extract, dark green agave extract, jujube fruit extract, curcuma longa rhizome extract, geranium maculatum extract, citrus aurantium dulcis seed extract and cinnamomum cassia bark extract. The application selects natural effective components in plants, camosine, vitamin E and palmitoyl tripeptide-1 and other substances reasonably, controls the amount of each component reasonably, makes each component play its own role fully, and makes the obtained composition and eye cream have obvious black removal and whitening effects, increase skin elasticity and improve eye wrinkle phenomenon.

The invention discloses high-lead soldering paste for a semiconductor and a manufacturing method of the high-lead soldering paste, and the high-lead soldering paste comprises the following components in percentage by weight: 85-90% of high-lead alloy powder and 10-15% of flux paste, the flux paste comprises the following raw materials in percentage by weight: 40%-50% of modified rosin, 2.5%-5% of phthalic acid, 2.5%-5% of hydroxyethyl propionic acid, 2%-5% of polyethylene glycol, 1%-2% of sodium dodecyl benzene sulfonate, 0.5%-1.5% of 2, 6-butylated hydroxytoluene, 0.5%-1% of benzotriazole, 10%-30% of propylene glycol, 5%-17% of ethylene glycol monobutyl ether and 2%-5% of hydroxyethyl cellulose. The high-lead soldering paste is easy to manufacture and operate, the obtained high-lead soldering paste has excellent wettability and welding reliability, the splashing rate in the welding process is low, residues after welding are free of corrosion, and the use requirements of high-reliability application scenes are met.

The invention belongs to the field of pharmaceutical preparations, and particularly relates to a novel application of tofacitinib or a pharmaceutical composition containing the tofacitinib, and the tofacitinib exists in a medicine in the form of tofacitinib or pharmaceutically acceptable salt of the tofacitinib. The medicine can be prepared into an external preparation, including an external solution and an external semisolid, the external solution includes a solution, a foaming agent, a spray, a tincture and a liniment, and the external semisolid includes an ointment, a cream, a gel, a patch and an emplastrum; the external preparation can be a tofacitinib foaming agent and comprises the following components: tofacitinib or pharmaceutically acceptable salt thereof, a solvent, a humectant, a foam stabilizer, a surfactant, a pH regulator, an antioxidant and water, and the antioxidant comprises L-arginine and butylated hydroxytoluene.

The invention belongs to the technical field of PET (polyethylene terephthalate) depolymerization catalysts, and relates to a method for generating BHET (butylated hydroxytoluene) by depolymerization based on a DBU-SiO2 catalyst, which comprises the following steps: adding waste PET and ethylene glycol into a depolymerization kettle for alcoholysis depolymerization reaction under the catalysis of an organic-inorganic hybrid nitrogen heterocyclic organic alkali loaded porous silica gel catalyst DBU-SiO2 to obtain a BHET monomer; the preparation process of the DBU-SiO2 comprises the following steps: adding silica gel into ethanol, stirring, adding 1, 8-diazacyclo [5.4. 0] undec-7-ene, carrying out heating reflux, and sequentially filtering, washing and drying to obtain the DBU-SiO2; the conversion rate of the PET polyester is 87.49 to 95.11 percent, and the yield of the BHET monomer is 76.84 to 80.03 percent. According to the method disclosed by the invention, the waste PET is depolymerized by adopting the DBU-SiO2 catalyst, so that the PET conversion rate and the BHET yield are remarkably improved.

The invention discloses a solar cell backboard base film and a preparation method, the solar cell backboard base film is composed of a core transparent layer and a PET enhancement layer which are formed by double-layer co-extrusion, and a functional coating which coats the outer side of the PET enhancement layer, and the core transparent layer is composed of polyimide, butylated hydroxytoluene and pentaerythritol stearate; the PET enhancement layer is composed of super bright PET, nano silicon dioxide and aluminum bis-caprylate; the functional coating is prepared from polyurethane, a UV-327 ultraviolet light absorber, butyl hydroxy anisd, a BYK-333 surfactant, diphenyl disulfide, ammonium polyphosphate, N-methyl pyrrolidone and aluminum dicaprylate. The solar cell backboard base film combines collaborative optimization of multifunctional components and advanced process design, has excellent performance in mechanical strength, weather resistance, fireproof performance and processability, and is suitable for high-end application requirements of the solar cell backboard base film.

The invention discloses a moisturizing and repairing matte lipstick and a preparation method thereof in the field of cosmetics. The lipstick comprises a polydimethylsiloxane vinyl polydimethylsiloxane cross-linked polymer, two novel modified compounds, namely a silica supported titanium complex pigment anchoring agent and amphiphilic block polyamide microspheres, jojoba oil, caprylic / capric triglyceride, isononyl isononanoate, hydrogenated polydecene, a colorant, namely titanium dioxide iron oxide red iron oxide yellow, and a colorant, namely silica supported titanium complex pigment anchoring agent, amphiphilic block polyamide microspheres, jojoba oil, caprylic / capric triglyceride, isononyl isononanoate and hydrogenated polydecene. The anti-aging agent is prepared from mica, tocopherol, ascorbyl palmitate, butylated hydroxytoluene, vanillin and carnauba wax microcrystalline wax ozokerite. Wherein the silica supported titanium complex pigment anchoring agent is prepared by step-by-step reaction of titanium silicalite, titanate and stearic acid, and the amphiphilic block polyamide microspheres are formed by amidation polycondensation of dimethyl acetone diformate and amino polydimethylsiloxane. The lipstick ingeniously solves the contradiction between the matt makeup effect and the moisturizing and repairing performance, and has the remarkable advantages of being durable in color, comfortable in skin feeling and capable of fading cheilogramma.

This invention provides a method for extracting astaxanthin from Haematococcus pluvialis and its application. The method includes the following steps: S1. Raw material pretreatment; S2. Enzymatic hydrolysis with a complex enzyme; S3. Solubilization with a surfactant; S4. Adsorption by iron(III) oxide-cellulose porous microspheres; S5. Magnetic separation and washing; S6. Astaxanthin elution and microsphere recovery; S7. Concentration and drying. This invention utilizes a complex enzyme consisting of cellulase, alginate lyase, and mannanase to synergistically hydrolyze the multilayer polysaccharide structure of thick-walled spores of Haematococcus pluvialis, thereby fully releasing astaxanthin. Furthermore, iron(III) oxide-cellulose porous microspheres with benzyl and octyl surface modifications are used for highly selective adsorption of astaxanthin, combined with magnetic separation technology, thus improving the astaxanthin yield. The extraction process of this invention is carried out under medium-low temperature conditions, and butylated hydroxytoluene is added to the eluent, effectively avoiding thermal degradation, photolysis, and oxidation of astaxanthin, resulting in a high retention rate of antioxidant activity in the obtained astaxanthin.

The invention belongs to the technical field of medicines, and particularly relates to a low-temperature medicine-carrying Yunnan Baiyao hot melt adhesive patch and a preparation method thereof. The patch is prepared from Yunnan Baiyao, an SIS framework material, liquid paraffin, polyisobutene, rosin, butylated hydroxytoluene and dementholized peppermint oil through low-temperature melting, drug loading and coating processes. The process effectively protects the activity of heat-sensitive drugs, avoids the use of organic solvents, and has the advantages of environmental protection, safety, low sensitization and the like. The patch has proper adhesion performance (the peel strength is 0.02-0.53 N / cm, and the displacement of the holding adhesive force within 2 hours is less than or equal to 9.0 mm), and is comfortable to use and easy to tear off. Pharmacodynamic experiments show that the patch is remarkably superior to traditional Yunnan Baiyao paste in anti-inflammatory and analgesic aspects, the auricle swelling rate is reduced by more than or equal to 51.5%, the twisting frequency is reduced by 65.8%, and the patch is suitable for preparing anti-inflammatory and analgesic drugs.

The invention relates to a melogabalin besylate patch as well as a preparation method and application thereof. The melogabalin besylate patch is prepared from the following raw materials in percentage by mass: 0.5 to 10 percent of melogabalin besylate, 25 to 40 percent of matrix, 0.1 to 1.5 percent of antioxidant, 0.05 to 0.15 percent of functional additive, 0.5 to 10 percent of cosolvent, 0.1 to 10 percent of transdermal enhancer, 36.5 to 48 percent of plasticizer and 13 to 32 percent of tackifier. On the basis of the total mass of the melogabalin besylate patch, the transdermal enhancer is prepared from the following components in percentage by mass: 0 to 2 percent of L-menthol and 0.5 to 1.5 percent of sucrose laurate; the antioxidant is butylated hydroxytoluene; the functional additive is chitosan oligosaccharide. The patch has good physical adhesion, and the release rate gt of the medicine after 24 hours; the cumulative permeation amount gt of the medicine after 24 hours; the medicine is convenient and safe to use, and the medicine effect is stable.

The invention belongs to the technical field of pharmaceutical analysis, and particularly relates to a method for improving the stability of a vitamin D3 related substance impurity reference substance, which comprises the following steps of: optimizing solvent composition (selecting an isooctane-isopropanol mixed solution and adding 2, 6-butylated hydroxytoluene), subpackaging under the protection of nitrogen, and freezing and storing at the temperature of 20 DEG C below zero to obtain the vitamin D3 related substance impurity reference substance. The reference substance solution of the impurity C and the impurity E of the vitamin D3 can be stably stored at-20 DEG C for more than 12 months and cannot deteriorate after being transported at normal temperature for 3-7 days, the problem that reference substances in the prior art are prone to deteriorate due to the influence of high temperature, illumination and oxygen is solved, correction factors are kept stable for a long time, and the reliability of detection data is guaranteed.