The invention belongs to the technical field of
veterinary drug preparations, and particularly relates to a compound
external ointment for treating parasites of dogs and cats and
skin tinea and a preparation method, the compound
external ointment comprises the following components by
mass percent: 2%-12% of selamectin, 3%-20% of
imidacloprid, 0.5%-2% of
terbinafine hydrochloride, 2%-12% of
dipropylene glycol monomethyl ether, 10%-50% of isopropanol, 9%-45% of
polyethylene glycol 400 and the balance of water. The
adhesive is prepared from, by weight, 9%-45% of
polyethylene glycol 3350, 5%-15% of caprylic / capric
polyethylene glycol
glyceride, 1%-8% of
oleyl alcohol, 0.5%-5% of
dimeticone, 0.01%-0.1% of
butylated hydroxytoluene and 1%-5% of cassava
starch polymethylsesquioxane. The preparation method comprises the following steps: uniformly stirring the selamectin, the
imidacloprid, the
terbinafine hydrochloride and the mixed
solvent, then mixing with the matrix (the
polyethylene glycol 400 and the
polyethylene glycol 3350 are heated and uniformly mixed in advance), the emulsifier and other components, and homogenizing. The compound selamectin ointment prepared by the invention can realize accurate administration at the edge of the
auricle of an animal, and not only can ensure that the
medicine is fully absorbed, but also can improve the compliance of animal administration; the composition not only can expel parasites in a
broad spectrum, but also has broad-spectrum
antifungal activity, and can prevent and treat a plurality of
skin diseases of pets.