Feed additive for breeding laying hens and preparation method thereof

Abstract

The invention relates to the technical field of feed, and discloses a feed additive for laying hen breeding and a preparation method thereof.The feed additive for laying hen breeding is obtained by drying vitamins, nicotinamide, an antioxidant butylated hydroxytoluene, calcium pantothenate, modified chitosan and liquorice, putting the materials into a stirrer, conducting smashing and then conducting mixing. The feed additive obtained by compounding the raw materials can promote the growth of laying hens and promote the organ development of the laying hens; the oxidation resistance and the immunocompetence of the laying hens are improved; amino acid and chitosan groups contained in the modified chitosan also play a better role in helping the growth of the laying hens. The feed additive can shorten the laying day age of laying hens, improve the laying rate, improve the quality of eggs, reduce the yield of inferior eggs, improve the body quality of the laying hens and the like, is a non-toxic, drug-resistant and residue-free laying hen feed additive, and can be widely applied to laying hen feeding feeds.

Description

Technical Field

[0001] The invention relates to the technical field of feed, in particular to a feed additive for laying hen breeding and a preparation method thereof. Background Art

[0002] In the production and breeding of commercial laying hens, the decline in the physical condition and egg quality of hens, the reduction in egg production rate and egg production, and the increase in culling rate and egg breakage rate in the late period of peak egg production have always troubled practitioners. The main reason is that farmers pursue premature laying of laying hens and high egg production peak, which causes high production stress. The result of high production stress will inevitably lead to metabolic disorders of nutrients in the body, decreased antioxidant capacity, and decreased immunity. Taking the example of a farmer raising 100,000 laying hens and a 1% decrease in egg production rate, about 30,000 fewer eggs are produced per month. The annual number of laying hens in my country is about 1.1 billion, and a 1% reduction in egg production will have a huge impact. Vitamins have the function of improving the physiological functions of laying hens and improving nutritional metabolism. Research on the application of vitamins to delay the decline in production performance in the late egg production period is of great significance to improving the economic benefits of breeding. Summary of the invention

[0003] 1. Technical issues to be resolved

[0004] In view of the deficiencies in the prior art, the present invention provides a feed additive for laying hen breeding and a preparation method thereof, which has the effects of improving the immunity of laying hens and increasing the egg production rate.

[0005] (II) Technical solution

[0006] To achieve the above object, the present invention provides the following technical solutions: a feed additive for laying hen breeding and a preparation method thereof, a feed additive for laying hen breeding, comprising the following components by weight: 5-15 parts by weight of vitamins, 6-11 parts by weight of nicotinamide, 0.1-0.3 parts by weight of antioxidant butylated hydroxytoluene, 4-8 parts by weight of calcium pantothenate, 2-4 parts by weight of modified chitosan, and 8-20 parts by weight of liquorice;

[0007] The vitamins include the following weight components: 2-3 weight parts of vitamin A, 1-2 weight parts of vitamin D3, 0.4-1 weight parts of vitamin E, 0.6-0.8 weight parts of vitamin K3, 0.7-1 weight parts of vitamin B1, 0.6-1.3 weight parts of vitamin B2, 1-2 weight parts of vitamin B6, 1-1.5 weight parts of vitamin B 12 .

[0008] Preferably, the preparation method of the modified chitosan is:

[0009] (1) adding 6-9 parts by weight of chitosan and 8-14 parts by weight of 6-caprolactone into N,N-dimethylformamide solvent for dissolution, adding 0.1-0.2 parts by weight of stannous octoate, introducing nitrogen protection, reacting at 100-120° C., and after the reaction is completed, dissolving the crude product with chloroform, washing with anhydrous ethanol, filtering and drying to obtain 6-caprolactone modified chitosan;

[0010] (2) adding arginine and 6-caprolactone modified chitosan into a reactor, stirring evenly, continuing to add p-toluenesulfonic acid catalyst, reacting at 110-125° C. for 4-8 hours, filtering after the reaction, washing and drying to obtain modified arginine;

[0011] (3) 2-6 parts by weight of N-glycine, 3-5 parts by weight of L-proline, 4-8 parts by weight of L-threonine, and 2-4 parts by weight of L-serine are mixed and added to N,N-dimethylformamide solvent, condensed and refluxed, heated and stirred at 50-75° C. until dissolved, and then parts by weight of sodium carbonate and parts by weight of zinc acetate are added, and then parts by weight of dimethyl carbonate are added, nitrogen is passed to remove air, and the reaction is carried out, and the mixture is filtered while hot, and frozen and dried to obtain intermediate 1;

[0012] (4) Add 6-caprolactone-modified chitosan, modified arginine, and intermediate 1 into a stirrer and stir to obtain modified chitosan.

[0013] Preferably, the reaction time in (1) is 2-5 h.

[0014] Preferably, the mass ratio of arginine, 6-caprolactone modified chitosan and p-toluenesulfonic acid catalyst in (2) is 1:1.2-1.4:0.02-0.03.

[0015] Preferably, the reaction time in (3) is 6-10 h.

[0016] Preferably, the mass ratio of 6-caprolactone modified chitosan, modified arginine and intermediate 1 in (4) is 1.2-1.3:1:0.8-1.5.

[0017] Preferably, the stirring time in (4) is 10-15 min.

[0018] Preferably, the preparation method of the feed additive for laying hen breeding is: vitamins, nicotinamide, antioxidant butylated hydroxytoluene, calcium pantothenate, modified chitosan, and licorice are dried and put into a blender at a drying temperature of 60-70° C. for 1.5-3 hours, and after crushing, they are mixed to obtain the feed additive for laying hen breeding.

[0019] (III) Beneficial technical effects

[0020] The present invention obtains a feed additive for laying hen breeding by drying vitamins, nicotinamide, antioxidant butylated hydroxytoluene, calcium pantothenate, modified chitosan, and licorice, putting them into a blender, crushing them, and mixing them. The feed additive obtained by compounding the raw materials can promote the growth of laying hens and the development of their organs; improve the antioxidant capacity and immune capacity of laying hens; and the amino acids and chitosan groups contained in the modified chitosan also play a good role in the growth of laying hens. The feed additive can shorten the laying age of laying hens, increase the egg production rate, improve the quality of eggs, reduce the production of inferior eggs, and improve the physical quality of laying hens. The feed additive is a non-toxic, non-resistant, and non-residue laying hen feed additive, which can be widely used in laying hen feeding feed. DETAILED DESCRIPTION

[0021] Example 1

[0022] (1) 6 parts by weight of chitosan and 8 parts by weight of 6-caprolactone are added to N,N-dimethylformamide solvent for dissolution, and then 0.1 parts by weight of stannous octoate is added, and nitrogen is introduced for protection, and the reaction is carried out at 100° C. The reaction is completed, wherein the reaction time is 2 hours, and the crude product is dissolved in chloroform, and then washed with anhydrous ethanol, filtered and dried to obtain 6-caprolactone modified chitosan;

[0023] (2) adding arginine and 6-caprolactone modified chitosan into a reactor, stirring evenly, and continuing to add p-toluenesulfonic acid catalyst, wherein the mass ratio of arginine, 6-caprolactone modified chitosan, and p-toluenesulfonic acid catalyst is 1:1.2:0.02, reacting at 110° C. for 4 h, filtering after the reaction, washing and drying to obtain modified arginine;

[0024] (3) 2 parts by weight of N-glycine, 3 parts by weight of L-proline, 4 parts by weight of L-threonine, and 2 parts by weight of L-serine are mixed and added to N,N-dimethylformamide solvent, condensed and refluxed, heated and stirred at 50° C. until dissolved, and then 1 part by weight of sodium carbonate and 1 part by weight of zinc acetate are added, and then 1 part by weight of dimethyl carbonate is added, and nitrogen is passed to remove air, and the reaction is carried out, wherein the reaction time is 6 hours, and the mixture is filtered while hot, and frozen and dried to obtain intermediate 1;

[0025] (4) adding 6-caprolactone-modified chitosan, modified arginine, and intermediate 1 into a stirrer, wherein the mass ratio of 6-caprolactone-modified chitosan, modified arginine, and intermediate 1 is 1.2:1:0.8, and stirring for 10 minutes to obtain modified chitosan;

[0026] (5) 5 parts by weight of vitamins, 6 parts by weight of nicotinamide, 0.1 parts by weight of antioxidant butylated hydroxytoluene, 4 parts by weight of calcium pantothenate, 2 parts by weight of modified chitosan, and 8 parts by weight of licorice are dried and placed in a blender at a drying temperature of 60° C. for 1.5 hours. After crushing, the mixture is mixed to obtain a feed additive for laying hen farming.

[0027] Example 2

[0028] (1) adding 9 parts by weight of chitosan and 14 parts by weight of 6-caprolactone to N,N-dimethylformamide solvent for dissolution, adding 0.2 parts by weight of stannous octoate, introducing nitrogen protection, reacting at 120° C., and completing the reaction, wherein the reaction time is 5 hours, dissolving the crude product with chloroform, washing with anhydrous ethanol, filtering and drying to obtain 6-caprolactone modified chitosan;

[0029] (2) adding arginine and 6-caprolactone modified chitosan into a reactor, stirring evenly, and continuing to add p-toluenesulfonic acid catalyst, wherein the mass ratio of arginine, 6-caprolactone modified chitosan, and p-toluenesulfonic acid catalyst is 1:1.4:0.03, reacting at 125° C. for 8 h, filtering after the reaction, washing and drying to obtain modified arginine;

[0030] (3) 6 parts by weight of N-glycine, 5 parts by weight of L-proline, 8 parts by weight of L-threonine, and 4 parts by weight of L-serine are mixed and added to N,N-dimethylformamide solvent, condensed and refluxed, heated and stirred at 75° C. until dissolved, and then 1 part by weight of sodium carbonate and 1 part by weight of zinc acetate are added, and then 1 part by weight of dimethyl carbonate is added, and nitrogen is passed to remove air, and the reaction is carried out, wherein the reaction time is 10 hours, and the mixture is filtered while hot, and frozen and dried to obtain intermediate 1;

[0031] (4) adding 6-caprolactone-modified chitosan, modified arginine, and intermediate 1 into a stirrer, wherein the mass ratio of 6-caprolactone-modified chitosan, modified arginine, and intermediate 1 is 1.3:1:1.5, and stirring for 15 minutes to obtain modified chitosan;

[0032] (5) 15 parts by weight of vitamins, 11 parts by weight of nicotinamide, 0.3 parts by weight of antioxidant butylated hydroxytoluene, 8 parts by weight of calcium pantothenate, 4 parts by weight of modified chitosan, and 20 parts by weight of licorice are dried and placed in a blender at a drying temperature of 70° C. for 3 hours. After crushing, the mixture is mixed to obtain a feed additive for laying hen farming.

[0033] Example 3

[0034] (1) adding 7 parts by weight of chitosan and 11 parts by weight of 6-caprolactone into N,N-dimethylformamide solvent for dissolution, adding 0.15 parts by weight of stannous octoate, introducing nitrogen protection, reacting at 110° C., and completing the reaction, wherein the reaction time is 3 hours, dissolving the crude product with chloroform, washing with anhydrous ethanol, filtering and drying to obtain 6-caprolactone modified chitosan;

[0035] (2) adding arginine and 6-caprolactone modified chitosan into a reactor, stirring evenly, and continuing to add p-toluenesulfonic acid catalyst, wherein the mass ratio of arginine, 6-caprolactone modified chitosan, and p-toluenesulfonic acid catalyst is 1:1.3:0.025, reacting at 117° C. for 6 h, filtering after the reaction, washing and drying to obtain modified arginine;

[0036] (3) 4 parts by weight of N-glycine, 4 parts by weight of L-proline, 6 parts by weight of L-threonine, and 3 parts by weight of L-serine are mixed and added to N,N-dimethylformamide solvent, condensed and refluxed, heated and stirred at 62° C. until dissolved, and then 1 part by weight of sodium carbonate and 1 part by weight of zinc acetate are added, and then 1 part by weight of dimethyl carbonate is added, and nitrogen is passed to remove air, and the reaction is carried out, wherein the reaction time is 8 hours, and the mixture is filtered while hot, and frozen and dried to obtain intermediate 1;

[0037] (4) adding 6-caprolactone-modified chitosan, modified arginine, and intermediate 1 into a stirrer, wherein the mass ratio of 6-caprolactone-modified chitosan, modified arginine, and intermediate 1 is 1.25:1:1.1, and stirring for 12 minutes to obtain modified chitosan;

[0038] (5) 10 parts by weight of vitamins, 8 parts by weight of nicotinamide, 0.4 parts by weight of antioxidant butylated hydroxytoluene, 6 parts by weight of calcium pantothenate, 6 parts by weight of modified chitosan, and 14 parts by weight of licorice are dried and placed in a blender at a drying temperature of 65° C. for 2.2 hours. After crushing, the mixture is mixed to obtain a feed additive for laying hen farming.

[0039] Example 4

[0040] (1) 6 parts by weight of chitosan and 8 parts by weight of 6-caprolactone are added to N,N-dimethylformamide solvent for dissolution, and then 0.1 parts by weight of stannous octoate is added, and nitrogen is introduced for protection, and the reaction is carried out at 100° C. The reaction is completed, wherein the reaction time is 2 hours, and the crude product is dissolved in chloroform, and then washed with anhydrous ethanol, filtered and dried to obtain 6-caprolactone modified chitosan;

[0041] (2) adding arginine and 6-caprolactone modified chitosan into a reactor, stirring evenly, and continuing to add p-toluenesulfonic acid catalyst, wherein the mass ratio of arginine, 6-caprolactone modified chitosan, and p-toluenesulfonic acid catalyst is 1:1.2:0.02, reacting at 110° C. for 4 h, filtering after the reaction, washing and drying to obtain modified arginine;

[0042] (3) 6 parts by weight of N-glycine, 5 parts by weight of L-proline, 8 parts by weight of L-threonine, and 4 parts by weight of L-serine are mixed and added to N,N-dimethylformamide solvent, condensed and refluxed, heated and stirred at 75° C. until dissolved, and then 1 part by weight of sodium carbonate and 1 part by weight of zinc acetate are added, and then 1 part by weight of dimethyl carbonate is added, and nitrogen is passed to remove air, and the reaction is carried out, wherein the reaction time is 10 hours, and the mixture is filtered while hot, and frozen and dried to obtain intermediate 1;

[0043] (4) adding 6-caprolactone-modified chitosan, modified arginine, and intermediate 1 into a stirrer, wherein the mass ratio of 6-caprolactone-modified chitosan, modified arginine, and intermediate 1 is 1.3:1:1.5, and stirring for 15 minutes to obtain modified chitosan;

[0044] (5) 10 parts by weight of vitamins, 8 parts by weight of nicotinamide, 0.4 parts by weight of antioxidant butylated hydroxytoluene, 6 parts by weight of calcium pantothenate, 6 parts by weight of modified chitosan, and 14 parts by weight of licorice are dried and placed in a blender at a drying temperature of 65° C. for 2.2 hours. After crushing, the mixture is mixed to obtain a feed additive for laying hen farming.

[0045] Example 5

[0046] (1) adding 9 parts by weight of chitosan and 14 parts by weight of 6-caprolactone to N,N-dimethylformamide solvent for dissolution, adding 0.2 parts by weight of stannous octoate, introducing nitrogen protection, reacting at 120° C., and completing the reaction, wherein the reaction time is 5 hours, dissolving the crude product with chloroform, washing with anhydrous ethanol, filtering and drying to obtain 6-caprolactone modified chitosan;

[0047] (2) adding arginine and 6-caprolactone modified chitosan into a reactor, stirring evenly, and continuing to add p-toluenesulfonic acid catalyst, wherein the mass ratio of arginine, 6-caprolactone modified chitosan, and p-toluenesulfonic acid catalyst is 1:1.4:0.03, reacting at 125° C. for 8 h, filtering after the reaction, washing and drying to obtain modified arginine;

[0048] (3) 4 parts by weight of N-glycine, 4 parts by weight of L-proline, 6 parts by weight of L-threonine, and 3 parts by weight of L-serine are mixed and added to N,N-dimethylformamide solvent, condensed and refluxed, heated and stirred at 62° C. until dissolved, and then 1 part by weight of sodium carbonate and 1 part by weight of zinc acetate are added, and then 1 part by weight of dimethyl carbonate is added, and nitrogen is passed to remove air, and the reaction is carried out, wherein the reaction time is 8 hours, and the mixture is filtered while hot, and frozen and dried to obtain intermediate 1;

[0049] (4) adding 6-caprolactone-modified chitosan, modified arginine, and intermediate 1 into a stirrer, wherein the mass ratio of 6-caprolactone-modified chitosan, modified arginine, and intermediate 1 is 1.25:1:1.1, and stirring for 12 minutes to obtain modified chitosan;

[0050] (5) 5 parts by weight of vitamins, 6 parts by weight of nicotinamide, 0.1 parts by weight of antioxidant butylated hydroxytoluene, 4 parts by weight of calcium pantothenate, 2 parts by weight of modified chitosan, and 8 parts by weight of licorice are dried and placed in a blender at a drying temperature of 60° C. for 1.5 hours. After crushing, the mixture is mixed to obtain a feed additive for laying hen farming.

[0051] Comparative Example 1

[0052] 5 parts by weight of vitamins, 6 parts by weight of nicotinamide, 0.1 parts by weight of antioxidant butylated hydroxytoluene, 4 parts by weight of calcium pantothenate, and 8 parts by weight of licorice are dried and put into a blender at a drying temperature of 60° C. and reacted for 1.5 hours. After crushing, they are mixed to obtain a feed additive for laying hen breeding.

[0053] 1200 chickens were divided into 6 groups, with 200 chickens in each group, and the egg production rate and egg production were tested.

[0054] Table 1: Egg production rate and egg production test.

[0055] project Egg production rate (%) Egg production (g) Example 1 86.5 45.86 Example 2 87.3 46.79 Example 3 86.7 45.91 Example 4 86.1 46.15 Example 5 87.2 47.37 Comparative Example 1 62.3 35.74

[0056] It can be seen from Table 1 that Examples 1-5 of the present invention have better egg production rate and egg production than Comparative Example 1.

[0057] The preferred embodiments of the present invention disclosed above are only used to help illustrate the present invention. The preferred embodiments do not describe all the details in detail, nor do they limit the invention to the specific implementation methods described. Obviously, many modifications and changes can be made according to the content of this specification. This specification selects and specifically describes these embodiments in order to better explain the principles and practical applications of the present invention, so that those skilled in the art can understand and use the present invention well. The present invention is limited only by the claims and their full scope and equivalents.

Claims

1. A feed additive for laying hen breeding, characterized in that: The invention comprises the following components by weight: 5-15 parts by weight of vitamins, 6-11 parts by weight of nicotinamide, 0.1-0.3 parts by weight of antioxidant butylated hydroxytoluene, 4-8 parts by weight of calcium pantothenate, 2-4 parts by weight of modified chitosan, and 8-20 parts by weight of liquorice; The vitamins include the following weight components: 2-3 weight parts of vitamin A, 1-2 weight parts of vitamin D3, 0.4-1 weight parts of vitamin E, 0.6-0.8 weight parts of vitamin K3, 0.7-1 weight parts of vitamin B1, 0.6-1.3 weight parts of vitamin B2, 1-2 weight parts of vitamin B6, 1-1.5 weight parts of vitamin B 12 .

2. The feed additive for laying hen breeding according to claim 1, characterized in that: The preparation method of the modified chitosan is: (1) adding 6-9 parts by weight of chitosan and 8-14 parts by weight of 6-caprolactone into N,N-dimethylformamide solvent for dissolution, adding 0.1-0.2 parts by weight of stannous octoate, introducing nitrogen protection, reacting at 100-120° C., and after the reaction is completed, dissolving the crude product with chloroform, washing with anhydrous ethanol, filtering and drying to obtain 6-caprolactone modified chitosan; (2) adding arginine and 6-caprolactone modified chitosan into a reactor, stirring evenly, continuing to add p-toluenesulfonic acid catalyst, reacting at 110-125° C. for 4-8 hours, filtering after the reaction, washing and drying to obtain modified arginine; (3) 2-6 parts by weight of N-glycine, 3-5 parts by weight of L-proline, 4-8 parts by weight of L-threonine, and 2-4 parts by weight of L-serine are mixed and added to N,N-dimethylformamide solvent, condensed and refluxed, heated and stirred at 50-75° C. until dissolved, and then parts by weight of sodium carbonate and parts by weight of zinc acetate are added, and then parts by weight of dimethyl carbonate are added, nitrogen is passed to remove air, and the reaction is carried out, and the mixture is filtered while hot, and frozen and dried to obtain intermediate 1; (4) Add 6-caprolactone-modified chitosan, modified arginine, and intermediate 1 into a stirrer and stir to obtain modified chitosan.

3. The feed additive for laying hen breeding according to claim 2, characterized in that: The reaction time in (1) is 2-5h.

4. The feed additive for laying hen breeding according to claim 2, characterized in that: The mass ratio of arginine, 6-caprolactone modified chitosan and p-toluenesulfonic acid catalyst in (2) is 1:1.2-1.4:0.02-0.

03.

5. The feed additive for laying hen breeding according to claim 2, characterized in that: The reaction time in (3) is 6-10 hours.

6. The feed additive for laying hen breeding according to claim 2, characterized in that: The mass ratio of 6-caprolactone modified chitosan, modified arginine and intermediate 1 in (4) is 1.2-1.3:1:0.8-1.

5.

7. The feed additive for laying hen breeding according to claim 2, characterized in that: The stirring time in (4) is 10-15 min.

8. The method for preparing the feed additive for laying hen breeding according to claim 1-2, characterized in that: The preparation method of the feed additive for laying hen breeding is as follows: vitamins, nicotinamide, antioxidant butylated hydroxytoluene, calcium pantothenate, modified chitosan and licorice are dried and put into a blender at a drying temperature of 60-70° C. for reaction for 1.5-3 hours, and then crushed and mixed to obtain the feed additive for laying hen breeding.