214results about "Magnesium organic compounds" patented technology

This disclosure relates to a select class of porous adsorbent, metal-organic frameworks (MOFs) capable of adsorbing carbon dioxide, their manufacturing, applications, and methods of use. Specifically, this disclosure relates to the solvo(hydro)thermal synthesis of a family of metal-organic frameworks, and their subsequent processing and transformation into material forms suitable for use in acid gas separations. More specifically, this disclosure relates to the preparation and recovery of MOFs at multiple scales of production, demonstrating the suitability and robustness of the materials thus obtained by the disclosed synthetic route and post-synthetic manipulation employed to tailor the materials for use in a variety of commercial acid gas separation systems, with improved performances, recyclability, and reuse characteristics.

The present invention discloses a preparation process of Grignard alcohol, which uses magnesium and methyl chloride as reaction raw materials, tetrahydrofuran as a solvent, and iodine crystals as an initiator. The Grignard reaction is carried out under nitrogen to generate a Grignard reagent, and then the Grignard reagent reacts with p-chlorobenzophenone by an addition reaction to generate Grignard alcohol. The magnesium includes pre-treated magnesium powder and magnesium strips. By simultaneously using magnesium powder and magnesium strips with specific mass ratios and size ratios and pre-treating them, the present invention can ensure the stable progress of the reaction and improve the reaction yield; in addition, by carrying out the treatment of removing water and peroxides from tetrahydrofuran, while ensuring the process safety, the yield of the Grignard alcohol product can be further improved.

The invention relates to the technical field of preparation of small molecule compound medicines, in particular to a preparation method of (S)-flurbiprofen. The method comprises the following steps: dropwise adding a tetrahydrofuran solution of 4-bromo-2-fluorobiphenyl into a mixture of tetrahydrofuran and magnesium, and reacting to generate a Grignard reagent; mixing tetrahydrofuran, (S)-vinyl chloride oxide and ferric acetylacetonate, dropwise adding the Grignard reagent, performing acidolysis ring opening, and performing methylation with methyl iodide and magnesium iodide to obtain an alpha-hydroxyl aromatic carboxylic acid derivative; and reacting with sodium chlorite, nitroxide free radicals and acetonitrile, and oxidizing to obtain the (S)-flurbiprofen. By introducing a chiral induction unit, effective transmission of chiral information is realized in a coupling stage, an original chiral center is not destroyed in a subsequent reaction, and a product is ensured to have a highly consistent configuration. According to the scheme, the technical problem that a method capable of remarkably improving the optical purity and yield of (S)-flurbiprofen is lacked in the prior art can be solved, and the method has good environmental friendliness and industrial application prospects.

The invention discloses a method for preparing 3-phenanthrenol. The method comprises coupling a compound 3-tert-butoxyphenylboronic acid and o-bromobenzaldehyde to obtain 3'-tert-butoxy-[1,1'-biphenyl]-2-formaldehyde, then reacting 2-(chloromethoxy)-2-methylpropane with magnesium chips in tetrahydrofuran to generate a Grignard reagent, followed by substitution with 3'-tert-butoxy-[1,1'-biphenyl]-2-formaldehyde, and reflux and water separation with p-toluenesulfonic acid to obtain 3'-tert-butoxy-2-(2"-tert-butoxyvinyl)-1,1'-biphenyl, and finally ring closure with methanesulfonic acid and de-tert-butylation to obtain 3-phenanthrenol. The method introduces tert-butyl protection, thereby increasing steric hindrance and reducing isomers during ring closure, and facilitating deprotection conditions. The obtained product can have a purity of more than 99.0% without the need for column chromatography.

The present invention provides a novel six-coordinate magnesium complex, a preparation method thereof and an application thereof, solving the technical problem that the existing disclosed magnesium complexes are still limited in actual catalytic applications. The present invention uses tert-butylmagnesium reagent to react with 4,4′-di-tert-butyl-2,2′-bipyridine (dtbpy), in-situ reducing 4,4′-di-tert-butyl-2,2′-bipyridine (dtbpy) to a radical anion, and then an addition reaction occurs to obtain the target product. The preparation method of the present invention is simple, the raw materials for preparation are simple and easily available, the yield is considerable, and the product has unique catalytic activity and can be truly applied as a catalyst in a catalytic reaction system.

The present invention relates to a display device comprisinga plurality of OLED pixels comprising at least two OLED pixels, the OLED pixels comprising an anode, a cathode, and a stack of organic layers, wherein the stack of organic layersis arranged between and in contact with the cathode and the anode, andcomprises a first electron transport layer, a first hole transport layer, and a first light emitting layer provided between the first hole transport layer and the first electron transport layer, anda driving circuit configured to separately driving the pixels of the plurality of OLED pixels,wherein, for the plurality of OLED pixels, the first hole transport layer is provided in the stack of organic layers as a common hole transport layer shared by the plurality of OLED pixels, and the first hole transport layer comprises(i) at least one first hole transport matrix compound consisting of covalently bound atoms and(ii) at least one electrical p-dopant selected from metal salts and from electrically neutral metal complexes comprising a metal cation and at least one anion and / or at least one anionic ligand consisting of at least 4 covalently bound atoms,wherein the metal cation of the electrical p-dopant is selected from alkali metals; alkaline earth metals, Pb, Mn, Fe, Co, Ni, Zn, Cd; rare earth metals in oxidation state (II) or (III); Al, Ga, In; and from Sn, Ti, Zr, Hf, V, Nb, Ta, Cr, Mo and W in oxidation state (IV) or less, a method for preparing the display device and a chemical compound for use therein.

A metal organic framework, comprising: an organic ligand; a structure Sx constituted by one or more of O2-, OH2, OH−, OCH3−, and OC2H5−; and a metal ion, wherein the metal organic framework has a structure SM-x, in the structure SM-x, two or more metal ions are bonded to one oxygen atom in the structure Sx, the number of the metal ions in a unit lattice is two or more, and a water absorption rate A obtained by formula (1) is 25% or more:water⁢ absorption⁢ rate⁢ A=(W1-W2) / W2(1)in the formula, W1 represents a mass of the metal organic framework after being left until an equilibrium moisture content is reached under conditions of a temperature of 25° C. and a relative humidity of 50%, and W2 represents a mass of the organic metal framework after obtaining the mass W1 and being left at a temperature of 200° C. for 1 hour.

The invention relates to a novel crystal form of serine magnesium represented by a chemical formula 1 and a preparation method thereof. The crystal form of the present invention has excellent thermal stability and moisture stability, can be stably stored without decomposition or crystal form transition even during long-term storage, and thus can be advantageously used as a pharmaceutical raw material for pharmaceutical products. # imgabs0 #

The present disclosure relates to a solid component for producing an olefin polymerization catalyst, its production method, and its use. The solid component contains (i) a magnesium compound represented by the following formula (1), (ii) a Lewis base (LB), and (iii) optionally a metal component other than magnesium, where LB is a compound represented by the general formula (II) or an amide compound represented by the general formula (II'). The solid component produced in the present invention has a good particle morphology, and a catalyst produced by using the solid component as a support is less likely to be crushed and has better stereostructure orientation in olefin polymerization, particularly propylene polymerization or copolymerization. [Formula 1] JPEG2023546624000060.jpg41169

The invention belongs to the technical field of medicine synthesis, and particularly relates to a preparation method of a cyclobenzaprine intermediate 5H-dibenzo [a, d] cycloheptatriene-5-ketone. The preparation method comprises the following steps: preparing a magnesium Grignard reagent by taking 2-(2-chlorine or bromostyrene) benzonitrile as an initial raw material, and performing intramolecular cyclization and acidification to obtain a target compound I; the whole process is moderate in reaction temperature and mild in condition, use of expensive catalysts and special production equipment is avoided, and the production cost can be effectively reduced; meanwhile, the use of carbon tetrachloride and bromine with higher toxicity is avoided, the operation is safe, and the method is more suitable for industrial application.

To provide a production method for a phthalocyanine compound that enables high-purity production of a phthalocyanine compound having an ester side chain.SOLUTION: A method for producing a phthalocyanine compound comprises a step of mixing a phthalonitrile compound represented by general formula (1), a metal compound, and a compound represented by general formula (5), wherein in general formula (1), Z1 to Z4 each independently represent a hydrogen atom, a halogen atom, an alkoxy group, or the like, and at least one of Z1 to Z4 is a substituent represented by general formula (2); in general formula (2), L represents an alkylene or arylene group, and R represents an alkyl group or an aryl group; and in general formula (5), R is the same as R in general formula (2).SELECTED DRAWING: None

The present invention relates to a method for preparing 4,4'-difluorobenzophenone from 4-chlorofluorobenzene, which comprises the following steps: (1) Using 4-chlorofluorobenzene as the starting material, reacting with magnesium chips in a solvent to prepare a 4-fluorophenylmagnesium chloride solution; (2) Adding the 4-fluorophenylmagnesium chloride solution to a triphosgene solution, and reacting to obtain the target product 4,4'-difluorobenzophenone. In the present invention, the ketone carbonyl group is introduced through triphosgene, the reaction conditions are mild, the Friedel-Crafts reaction or diazotization reaction can be avoided, the use of aluminum trichloride or the generation of diazonium salts with explosion hazards can be avoided, the environmental pollution is small, the operation is safe and simple, and there is no corrosion to the equipment; the starting material 4-chlorofluorobenzene used has a wide source and low cost; the present invention has high yield and repeatability and is easy to be industrially produced.

The present invention relates to a process for providing 4-chloro-2-(trifluoromethyl)phenyl Grignard compound. Further, the present invention relates to the process for preparation of 4-chloro-2-(trifluoromethyl)phenyl compounds from 4-chloro-2-(trifluoromethyl)phenyl Gri- gnard compound, in particular to the process for the preparation of substituted phenoxy- phenyl ketones.

Primary, secondary (1°,2°) alkylethylenediamine- and alkylpropylenediamine- appended variants of metal-organic framework are provided for CO2 capture applications. Increasing the size of the alkyl group on the secondary amine enhances the stability to diamine volatilization from the metal sites. Two-step adsorption / desorption profiles are overcome by minimizing steric interactions between adjacent ammonium carbamate chains. For instance, the isoreticularly expanded framework Mg2(dotpdc) (dotpdc4- =4,4"-dioxido-[1,1':4',l"-terphenyl]-3,3"-dicarboxylate), yields diamine-appended adsorbents displaying a single CO2 adsorption step. Further, use of the isomeric framework Mg-IRMOF-74-II or Mg2(pc-dobpdc) (pc-dobpdc4- = 3,3-dioxidobiphenyl-4,4-dicarboxylate, pc = para-carboxylate) also leads to a single CO2 adsorption step with bulky diamines. By relieving steric interactions between adjacent ammonium carbamate chains, these frameworks enable step-shaped CO2 adsorption, decreased water co-adsorption, and increased stability to diamine loss. Variants of Mg2(dotpdc) and Mg2(pc-dobpdc) functionalized with large diamines such as N-(n-heptyl)ethylenediamine have utility as adsorbents for carbon capture applications.

This invention relates to the field of organic synthesis technology, specifically to a highly efficient and stable Grignard preparation and its green preparation method. By weight, it comprises 8-18 parts of a magnesium source, 40-92 parts of a halogenated hydrocarbon, 150-200 parts of a green solvent, 15-20 parts of ethylene glycol dimethyl ether, and 2.3-3.2 parts of a synergistic stabilizer. The green solvent is 2-methyltetrahydrofuran, or a composite solvent with a weight ratio of 2-methyltetrahydrofuran:methyl tert-butyl ether of 150-160:40-50. The synergistic stabilizer is composed of 1.5-2.0 parts of N,N,N',N'-tetramethylethylenediamine and 0.8-1.2 parts of butylated hydroxytoluene, or composed of 1.5-2.0 parts of N,N,N',N'-tetramethylethylenediamine and 1.0 part of phenothiazine. This invention uses a green solvent system to replace traditional toxic and harmful solvents, and combines it with a solvent recovery process to achieve solvent recycling, which greatly reduces waste emissions and makes the production process safer and more environmentally friendly, in line with the development direction of green chemical industry.

The present invention discloses a method for preparing 1-aryl-3-arylsulfinylbicyclo[1.1.1]pentane. Under inert gas protection, an aryl Grignard reagent is reacted with [1.1.1] propeller alkane, and the resulting intermediate solution is reacted with an SO2 source. After the reaction is completed, 1-aryl-3-arylsulfinylbicyclo[1.1.1]pentane is obtained by post-processing. The present invention achieves efficient preparation of 1-aryl-3-arylsulfinylbicyclo[1.1.1]pentane without adding any catalyst, and has low raw material cost, easy operation, mild conditions, and high reaction yield, and has broad application value.

The invention provides a preparation method of pyruvic acid-1-13C, and relates to the technical field of chemical drugs, and the preparation method comprises the following steps: carrying out reaction and post-treatment on 13C-carbon dioxide and a Grignard reagent to obtain pyruvic acid-1-13C; wherein the Grignard reagent comprises a Grignard reagent obtained by reacting magnesium with acetyl halide. The technical problems that in the prior art, a pyruvic acid-1-13C synthesis method has safety risks, raw materials are not easy to obtain, the number of reaction reagent types is large, the number of process steps is large, and the yield is low are solved, the technical effects that safety and environmental protection are achieved, the raw materials are easy to obtain, the process is simple, and the synthesis route is short are achieved, and the obtained pyruvic acid-1-13C is high in purity and high in yield. And clinical test requirements can be met.

The invention relates to a method for synthesizing (R)-3-methylheptanoic acid. According to the method, the application range of steroid sapogenin degradation waste is further expanded. According to the method disclosed by the invention, the (R)-3-methyl-heptanoic acid can be conveniently obtained by taking the (R)-4-methyl-gamma-butyric acid lactone obtained by degrading steroid sapogenin as a raw material. According to the method provided by the invention, the use of highly toxic and controlled reagents is avoided, high-risk reactions such as hydrogenation in the prior art are avoided, and the method is mild in reaction condition and low in synthesis cost. Meanwhile, the utilization rate of steroid sapogenin resources is increased, and waste generated in the utilization process of the steroid sapogenin resources is reduced.

The present invention relates to halogenated alkenylalkoxymethyl ether compounds of the following general formula (1): R 1 CH2OCH2OCH2CH2CH=CH(CH2) a X 1 (1), wherein R 1 represents a hydrogen atom, a n-alkyl group having 1 to 9 carbon atoms, or a phenyl group, X 1 represents a halogen atom, and a represents an integer of 3 to 14. The present invention also relates to a method for producing terminal conjugated alkadien-1-yl acetate compounds of the following general formula (5): CH2=CHCH=CH(CH2) a OAc (5), wherein a is defined as above, and Ac represents an acetyl group, and a method for producing terminal conjugated alkadien-1-ol compounds of the following general formula (6): CH2=CHCH=CH(CH2) a OH (6), wherein a is defined as above.

The present invention relates to a process for the production of an intermediate useful in organic synthesis, in particular for the production of astaxanthin.

A process of manufacturing a functionalized porous material includes: mixing a base porous material comprising a porous structure and a labile ligand with a functionalizing agent to form a slurry, the porous structure having open metal sites and a plurality of pores, wherein the labile ligand is coordinated to the open metal sites, present in the plurality of pores but not coordinated to the open metal sites, or a combination thereof, the labile ligand has a first boiling temperature and the functionalizing agent has a second boiling temperature that is higher than the first boiling temperature; and drying the slurry to form a functionalized porous material comprising the functionalizing agent coordinated to the open metal sites.

The present invention provides 5-(2-butyl-1,3-dioxolan-2-yl)-1-methylpentyl acetate of the following formula (1). The present invention further provides the aforesaid 5-(2-butyl-1,3-dioxolan-2-yl)-1-methylpentyl acetate (1), the process comprising the step of subjecting an organic magnesium compound (2) of the following general formula (2), wherein X1 represents a halogen atom or a 3-(2-butyl-1,3-dioxolan-2-yl)propyl group, to a nucleophilic addition reaction with propylene oxide of the following formula (3) and then reacting with an acetylating agent of the following general formula (4), wherein X2 represents a halogen atom, an acetoxy group, a methoxy group, or an ethoxy group, to form 5-(2-butyl-1,3-dioxolan-2-yl)-1-methylpentyl acetate (1).

The purpose of the present invention is to produce a high-quality metal-organic structure in a short period of time. The method for producing a metal-organic structure according to the present invention comprises applying centrifugal force and shearing force simultaneously and continuously to a formulation containing a metal ion donor, a polydentate ligand, and a solvent.

Provided is a metal hydroxide composite including a base layer, a surface layer, and an active ingredient, the metal hydroxide composite including a multilayer hydroxide structure of Chemical Formula 1; a metal hydroxide composite prepared by including a step of co-precipitating an active ingredient and a metal hydroxide structure precursor by a precipitation reaction using an alcohol and water, and a method for preparing the same.

To provide a metal complex which is useful for producing a negative electrode active material having superior initial coulombic efficiency and capacity retention and a method for producing the same, a negative electrode active material precursor containing the metal complex and a method for producing the same, a negative electrode active material, and a secondary battery having the negative electrode active material.SOLUTION: A metal complex contains a metal cation, the counterion of which includes a carboxylate anion having 2-20 carbon atoms and having a protected amino group.SELECTED DRAWING: None

The invention relates to a solid-liquid exothermic reaction device which is characterized by comprising a reaction kettle, a first solid-liquid separator, a material guide pump, a second solid-liquid separator and an external heat exchanger which are sequentially connected in series, wherein the top or the upper part of the first solid-liquid separator is provided with a reactant lead-in port connected with the reaction kettle and a light component lead-out port connected with the material guide pump, and the bottom of the first solid-liquid separator is provided with a heavy component lead-out port connected with the reaction kettle; the top or the upper part of the second solid-liquid separator is provided with a light component leading-out port connected with the external heat exchanger, and the bottom of the second solid-liquid separator is provided with a heavy component leading-out port connected with the reaction kettle; and a discharge hole of the external heat exchanger is connected with the reaction kettle. The invention further relates to continuous solid-liquid exothermic reaction equipment using the solid-liquid exothermic reaction device.

The method discloses a green synthesis process of acetylene alcohol double Grignard reagent, and the synthesis process comprises the following steps: dissolving benzyl chloride in an organic solvent to prepare solution A, adding metal magnesium to solution A to initiate a reaction, and preparing an initiation reaction solution; (2) dissolving benzyl chloride and acetylene alcohol substances in an organic solvent to prepare solution B; (2) adding solution B in step (2) to the initiation reaction solution in step (1) dropwise to perform a reaction, and preparing acetylene alcohol double Grignard reagent. The application provides a new synthesis method for synthesizing acetylene alcohol double Grignard reagent by using benzyl magnesium chloride, which can avoid a coupling side reaction between benzyl Grignard reagent and benzyl chloride, and does not need excessive metal magnesium.

The present invention relates to an organic electronic device comprising a semiconductor layer, wherein the semiconductor layer comprises a compound of formula (1).

The present disclosure provides a composite metal salt having a hexagonal Cd(OH)2 type crystal structure and an X-ray diffraction intensity ratio (orientation H) of the (101) plane to the (001) plane of 60% or less, and being denoted by the following formula (1):wherein “M2+” denotes at least one divalent metal other than Mg; “A” denotes at least one organic ligand; “x” denotes a number in a range of 0≤x<0.2; “y” denotes a number in a range of 0<y<0.05; and “n” denotes an integer of from 1 to 4, or zero.

The invention provides a method for efficiently preparing L-menthyl formic acid. The method comprises the following steps: a) dispersing magnesium chips, an initiator and anhydrous lithium halide in an ether organic solvent; b) dropwise adding 10% of L-menthyl chloride required by reaction into the previous step, then heating to a corresponding initiation temperature, then continuously dropwise adding the rest L-menthyl chloride, and carrying out heat preservation and stirring after dropwise adding is finished; and c) introducing carbon dioxide gas into the solution obtained in the previous step, and then adding acid for quenching reaction to obtain a target product. According to the method, L-menthyl chloride, magnesium chips and carbon dioxide are used as reaction raw materials, alkyl magnesium chloride is used as an initiator, and anhydrous lithium halide is used as a stabilizer, so that the stability of L-menthyl magnesium chloride is improved, and high-purity L-menthyl formic acid is obtained at a relatively high yield in the reaction process.