632results about "Magnesium organic compounds" patented technology

The invention provides a magnesium halide addition compound shown as general formula MgX2-mROH-nE-pH2O, wherein, X refers to chlorine or bromine, R refers to the alkyl of C1-C12; naphthene base of C3-C10 or the aryl of the C6-C10; E refers to o-alkoxybenzoic ether compound shown in the general formula (II); m ranges from 1 to 5; n ranges from 0.005 to 1.0; and P ranges from 0 to 0.8.

A chelate comprised of creatine bonded to an essential mineral selected from the group consisting of Mg, Ca, Cu, Zn, Fe, Cr, Co, Mo, Se and Mn to form a heterocyclic ring. Preferably, the metal is Mg, but Ca, Zn, Fe, Cr and Mn are also preferred. The creatine chelates of the present invention are capable of being absorbed in the stomach or intestines via active transport without substantial metabolism of the chelate. In other words, the creatine ligand is protected by the metal from undergoing cyclization in the acidic environment of the stomach and the metal is made more bioavailable due to the presence of the creatine ligand.

The invention provides a spherical magnesium halide adduct and a preparation method thereof. The method comprises the following steps of: (1) mixing magnesium halide and alcohols except methanol with optional inert liquid media and heating the obtained mixture under stirring until a melt of the magnesium halide adduct is formed; (2) adding the melt of the magnesium halide adduct to cooling media after shearing and dispersing the melt to form spherical solid particles; and (3) carrying out contact reaction on the spherical solid particles and dimethoxy propane in the inert dispersion media. The invention also provides application of the magnesium halide adduct as a catalyst carrier. The magnesium halide adduct has the following beneficial effects: the morphology of particles of the magnesium halide adduct is more regular and is basically spherical; the particle size distribution is more concentrated; basically special-shaped particles do not exist; and the catalyst prepared by adopting the spherical magnesium halide adduct as the catalyst carrier has better hydrogen regulation sensitivity in propylene polymerization reaction.

The invention provides a coordination polymer material with a multistage pore passage structure and a preparation method thereof. The coordination polymer material with a multistage pore passage structure is internally provided with the multistage pore passage structure, the multistage pore passage structure is a microporous and/or mesoporous and/or macroporous multistage pore passage structure which is formed by the self assembly between the metal ion and the organic ligand, the apertures of the micropores are less than or equal to 2nm, the apertures of the mesopores are from 2nm to 50nm, and the apertures of the macropores are more than 50nm. The coordination polymer material with a multistage pore passage structure is large in specific surface, the large-size organic ligand does not need to be synthesized, and the coordination polymer material with larger porous sizes can be obtained without the template agent and the pore assisting agent, so that the invention is simple in preparation method, and low in cost.

The invention provides a spherical magnesium halide adduct and a preparation method and application thereof. The method comprises the following steps of: (1) mixing magnesium halide, alcohol except methanol, and an optional inert liquid medium, and heating the obtained mixture with stirring to form a magnesium halide adduct melt; (2) performing shear dispersion on the magnesium halide adduct melt, and adding into a cooling medium to form spherical solid particles; (3) performing contact reaction on the spherical solid particles and dimethoxy propane in an inert dispersion medium; and (4) performing contact reaction on a product obtained in the step (3) and a polyol ester compound in the inert dispersion medium. The magnesium halide adduct has a good particle shape, a smooth surface and high liquidity, and special-shaped particles do not exist; and a catalyst prepared by taking the magnesium halide adduct as a catalyst carrier has high hydrogen regulation sensitivity when used for olefin polymerization.

A magnesium battery, having an anode containing magnesium; a cathode stable to a voltage of at least 2.6 V relative to a magnesium reference; and an electrolyte containing an electrochemically active magnesium salt obtained by reaction of a Grignard reagent or Hauser base with a boron compound of formula BR₃ is provided. The electrolyte is stable to 2.6 E.V. vs. Mg in the presence of stainless steel.

The invention provides a quadridentate pyridyl schiff base metal complex with a structure as shown in a formula (I) or (II), a preparation method of the metal complex as well as a preparation method of cyclic carbonate. The cyclic carbonate is prepared by cycloaddition of carbon dioxide and epoxide in the presence of the quadridentate pyridyl schiff base metal complex and a catalyst promoter, namely quaternary ammonium salt. During cycloaddition, the quadridentate pyridyl schiff base metal complex as a main catalyst has high catalytic activity, thereby enhancing the reaction rate of cycloaddition, and also has good product selectivity, thereby enhancing the yield of cyclic carbonate in a product. Experiment results show that the product selectivity of the quadridentate pyridyl schiff base metal complex is higher than 99% and cycloaddition singly generates cyclic carbonate.

Compounds and pharmaceutical compositions for use in the treatment and/or prophylaxis of cartilage and/or bone conditions and for methods of treating such condition. The compounds are salts of strontium that have a water-solubility of from about 1 g/l to about 100 g/l at room temperature, especially amino acid salts of strontium or dicarboxylic acid salts of strontium. Examples of novel water-soluble strontium salts are e.g. strontium glutamate and strontium alpha-ketoglutarate. The present invention also relates to an improved method for preparing the strontium salt of glutamic acid.

Partially and fully fluorinated alkyl substituted thienothiophene monomers (and polymers thereof) wherein the monomers are represented by the formula:

wherein R is a partially or fully fluorinated primary, secondary or tertiary alkyl having from 1 to 8 carbon atoms; and

X and X′ are independently selected from the group consisting of H, F, Cl, Br, I, MgCl, —COR″, —C≡CH, and a polymerizable cyclic pi-conjugated carbon-ring structure optionally comprising S, N or O heteroatoms; wherein R′ is a primary, secondary or tertiary alkyl having from 1 to 6 carbon atoms, and R″ is H or a primary, secondary or tertiary alkyl having from 1 to 6 carbon atoms.

This invention is related to Group 2 metal-containing polydentate β-ketoiminate precursors and compositions comprising Group 2 metal-containing polydentate β-ketoiminate precursors, wherein the polydentate β-ketoiminate precursors incorporate an alkoxy group in the imino portion of the molecule. The compounds and compositions are useful for fabricating metal containing films on substrates such as silicon, metal nitride, metal oxide and other metal layers via chemical vapor deposition (CVD) processes.

Perfluoroaryl Grignard reagents are produced from a hydrocarbyl Grignard reagent and polyhaloaromatic compounds via separate additions of different polyhaloaromatic compounds, such that the conversion of hydrocarbyl Grignard reagent to the desired perfluoroaryl Grignard reagent is essentially complete, and thus the reaction product is free or essentially free of agents that may negatively affect subsequent reactions. The perfluoroaryl Grignard reagents may be further reacted with boron trihalides in order to obtain tris(perfluoroaryl)boranes or tetrakis(perfluoroaryl)borates.

A method for synthesizing particulate or loosely agglomerated nano-metal organic framework crystals having an average particle size less than 100 nm. A base compound is added to a solution of a metal salt and an organic polydentate ligand with thorough stirring at a temperature between about 15° C. and about 30° C. for a time less than about 4 hours.

A process for the preparation of a heterocyclic macrocycle-templated supramolecular metal organic material, the process comprising preparing a reaction mixture containing a metal, a heterocyclic macrocycle, and organic ligands and forming, in the reaction mixture, a heterocyclic macrocycle-templated metal organic material comprising the metal, the heterocyclic macrocycle and the ligands by template-directed synthesis with the heterocyclic macrocycle serving as the template and being encapsulated within a cage of the template metal organic material.

The invention provides a continuous production method of a Grignard reagent, a mode of connecting n kettles in series is adopted, and the Grignard reagent is obtained through continuous Grignard reaction of halide and magnesium, wherein n is greater than or equal to 2; the production method comprises a continuous Grignard starting step and a continuous Grignard reaction operation step. The method effectively solves the problems of triggering and heat dissipating of the Grignard reaction, the potential safety hazards like blanking or explosion caused by the dramatic temperature rise of the Grignard reaction are avoided, meanwhile, the stability of control in the process of the Grignard reaction is improved, and the influences of human factors on the synthesis of the Grignard reagent are reduced.

The invention provides a method for industrial production of a butoconazole nitrate intermediate, that is 1-chloro-4-p-chlorophenyl-2-butanol (a compound in formula II). The method of the invention comprises: 1. a Grignard reaction, that is, adopting p-chlorobenzyl chloride as a raw material, and performing a Grignard reaction with magnesium powder in a mixed solvent of methyl tertiary butyl ether and tetrahydrofuran; 2. a condensation reaction, that is, continuing reaction by adding epichlorohydrin to obtain the compound II which is an important intermediate for preparing butoconazole nitrate. According to the method, the raw materials are cheap and easily available, the reaction solvent is safer, and the method is suitable for industrial production.

The present invention provides an efficient method to induce the enantioselectivity in procarbonyl compounds using chiral organometallic complexes. The present invention also provides a method for producing chiral organometallic complexes using a chiral additive, achiral additive, a base and a metal salt.

The invention relates to the field of pharmaceutical chemical synthesis, in particular to a preparation method of flurbiprofen and a preparation method of flurbiprofen axetil. The preparation method of the flurbiprofen comprises the steps of carrying out a Grignard reaction by using 4-bromine-2-fluorine biphenyl as a raw material, carrying out a coupling reaction, and acidizing to obtain the flurbiprofen; the yield is 90%, and the purity is 99.5%; then, the flurbiprofen axetil is prepared by using the flurbiprofen, obtained by the method, as a raw material, the yield reaches up to 90%, and thepurity reaches up to 99.5%. The preparation methods are high in quality controllability and industrial reproducibility.

The invention discloses a solventless synthesis method for a metal polynitrogen azole framework material and belongs to the preparation field of porous coordination polymers. The synthesis method of the invention mainly comprises the following steps: uniformly mixing a polynitrogen azole ligand and a metal oxide or metal hydroxide in a stoichiometric ratio of the target metal polynitrogen azole framework material, heating, and reacting to obtain the required metal polynitrogen azole framework material. In the synthesis method, the need of adding solvent and other additives are avoided, the process steps are simplified, the product yield is very high, the reaction byproduct or waste liquid treatment problem is eliminated, and vapor is the only byproduct and does not affect subsequent reactions; the purity of the obtained metal polynitrogen azole framework material is high, the crystallizing property is excellent, the crystalform is controllable and the specific surface area is very high; and the metal polynitrogen azole framework material can be used for absorption storage, separation and the like. The synthesis method has no requirement on the size of the reactor and can be used in production at various scales.

The invention discloses a device for the continuous preparation of a Grignard reagent and a method for the continuous preparation of the Grignard reagent through using the device. The device comprises a solvent storage container, a solvent-raw material mixing container, a raw gas storage container, a preheater, a reactor, a magnesium adding bin, a gas-liquid separator, a Grignard reagent reception container and a tail gas recovery apparatus, wherein the reactor adopts a three-phase bubble slurry column reactor. A purpose of the continuous preparation of the Grignard reagent can be realized through using the device of the invention, and initiation and heat radiation problems of a Grignard reaction can be effectively solved through adopting the three-phase bubble slurry column reactor, so potential safety hazards of material rush-out, explosion and the like caused by the severe temperature rise of the Grignard reaction can be effectively avoided, the obstruction of valves and pipelines by magnesium shreds can be prevented, and the high purity Grignard reagent can be obtained; and the tail gas recovery apparatus is arranged in the invention to absorb and recycle tail gases, so the cost is saved, and the environmental pollution is reduced, thereby cleaning and environmental protection requirements of the preparation of the Grignard reagent are realized.

A method for the formation of 3-alkylthiophenes or 3-arylthiophenes from 3-halothiophenes. More particularly, improvements on the Kumada coupling reaction for the production of 3-alkylthiophenes or 3-arylthiophenes by reacting a 3-halothiophene with an alkylmagnesiumhalide or arylmagnesiumhalide Grignard reagent in the presence of a catalyst and a 2-methyl tetrahydrofuran solvent. The 2-methyl tetrahydrofuran solvent allows for higher concentrations of the Grignard reagent with minimal or no dithienyl side product generation, achieving higher product yields and at a lower cost than other known methods.