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21 results about "External Ointment" patented technology

Traditional Chinese medicine compound external preparation for invigorating kidney and strengthening yang and preparation method thereof

The invention provides a traditional Chinese medicine compound external preparation for invigorating the kidney and strengthening Yang and a preparation method thereof, belongs to the technical field of traditional Chinese medicine preparations, and aims to solve the problems that the bioavailability of the first-pass effect of existing oral administration is low, and effective components of external ointment are difficult to penetrate through the skin. The preparation is a composite gel containing a penetration enhancer and a temperature-sensitive gel matrix, and the traditional Chinese medicine compound at least comprises various active ingredients of male silkworm moth, centipede, epimedium, rhizoma curculiginis, cistanche, schisandra chinensis, semen cuscutae, polygala tenuifolia, fructus cnidii, semen allii tuberosi, actinolite, sulfur, venenum bufonis, amethyst and borneol. According to the preparation disclosed by the invention, the transdermal permeation rate and the cumulative permeation amount of various active ingredients in the compound are improved in order of magnitude, so that an effective treatment concentration can be ensured to be reached in an in-vitro local or in-vivo system. In clinical application, the traditional Chinese medicine composition has better effect taking speed and treatment effect than external application or oral administration of traditional prescriptions with the same name.
Owner:南充市中医医院

Traditional Chinese medicine composition for treating rheumatic bone pain and preparation method thereof

The invention discloses a traditional Chinese medicine composition for treating rheumatic bone pain and a preparation method of the traditional Chinese medicine composition, and relates to the technical field of traditional Chinese medicines. The ointment consists of traditional Chinese medicine components and auxiliary materials, wherein the traditional Chinese medicine components of the ointment are prepared from the following components: unprocessed radix aconiti, unprocessed radix aconiti kusnezoffii, scorpio, centipede, earthworm, frankincense, myrrh, notopterygium root, radix angelicae pubescentis, radix clematidis, gentiana macrophylla, lycopodium clavatum, safflower and phryma leptostachya; the decoction is prepared from the following components: eucommia ulmoides, longspur epimedium, radix rehmanniae preparata, raw astragalus membranaceus, teasel root, semen cuscutae, radix achyranthis bidentatae, radix clematidis, salvia miltiorrhiza, radix aconiti preparata, prepared kusnezoff monkshood root, angelica sinensis and liquorice. According to the invention, a treatment mode of combining external use of ointment and oral administration of decoction is innovatively adopted, aiming at the pathogenesis characteristics of rheumatism ostalgia, local symptoms are rapidly relieved through the external ointment, the internal organ function is fundamentally conditioned through the oral decoction, the treatment strategy of treating symptoms in emergency and treating root causes in slow is realized, and the clinical curative effect is remarkably improved.
Owner:THE SECOND AFFILIATED HOSPITAL OF SHAANXI UNIV OF CHINESE MEDICINE

Traditional Chinese medicine ointment containing deer sinew powder and tortoise shell powder and preparation method of traditional Chinese medicine ointment

The invention discloses a traditional Chinese medicine ointment containing deer sinew powder and tortoise shell powder and a preparation method thereof. The traditional Chinese medicine ointment is prepared from the following raw materials in parts by weight: 5-10 parts of deer sinew powder, 3-6 parts of deer tortoise shell powder, 8-12 parts of radix bupleuri, 8-12 parts of radix curcumae, 10-15 parts of spica prunellae, 10-15 parts of bulbus fritillariae thunbergii, 8-12 parts of radix angelicae sinensis, 6-10 parts of rhizoma chuanxiong, 5-8 parts of frankincense, 5-8 parts of myrrh, 100-150 parts of vaseline and 20-30 parts of beewax. According to the invention, the defects of limited effect, single curative effect, shallow action level, poor long-term effect and the like due to the adoption of conventional medicinal materials for soothing liver, regulating qi, promoting blood circulation and removing blood stasis in the use process of the existing external ointment are overcome.
Owner:HUBEI TIANYI HEALTH RESEARCH INSTITUTE (LLP)

External ointment for rhinitis as well as preparation method and application of external ointment

PendingCN121129953AAerosol deliveryOintment deliveryLithospermumSesame Oils
The invention discloses an external ointment for rhinitis, a preparation method and application, which can effectively treat chronic rhinitis with nasal obstruction, sneezing and dry nose as main symptoms, and the ointment is non-invasive, convenient and non-irritant to skin. The external ointment for rhinitis comprises the following raw materials in percentage by mass: 5% of ephedra, 5% of almond, 5% of cocklebur fruit, 5% of wine-processed scutellaria baicalensis, 5% of radix angelicae, 5% of moutan bark, 5% of lithospermum, 5% of magnolia flower, 5% of selaginella tamariscina, 2.5% of borneol, 45% of sesame oil and 7.5% of beewax.
Owner:CHINA JAPAN FRIENDSHIP HOSPITAL

Compound external ointment for treating trichophyton rubrum infection and preparation process thereof

PendingCN121313544AOrganic active ingredientsAntimycoticsAntifungalSaturated phosphatidylcholine
The invention relates to the field of dermatological external preparations, in particular to a compound external ointment for treating trichophyton rubrum infection and a preparation process of the compound external ointment. The ointment specifically comprises the following components in percentage by weight: 0.50-1.50% of an antifungal active ingredient; 0.50% to 2.00% of saturated phosphatidylcholine; 0.20%-0.40% of a cross-linked acrylic rheology modifier; 4.0 to 10.0% of an oil phase; 0.10%-0.30% of a cationic film forming agent; 0.02 to 0.05 percent of a metal ion chelating agent; and water to 100%. And the pH value is adjusted to 4.6-4.9. Through cooperation of the saturated phosphatidylcholine, the cross-linked acrylic acid gel, the cationic film-forming agent and the chelating agent and pH control, the formula does not collapse, does not cause phase separation and is stable in release in the presence of sweat, the effective dose of the skin superficial layer can be maintained, and trichophyton rubrum can be continuously inhibited.
Owner:HEILONGJIANG TIANCHEN PHARM CO LTD

A constant temperature storage device for external use medicine paste

This utility model relates to the field of constant temperature storage technology for ointments, specifically a constant temperature storage device for external ointments. It includes a medicine storage cabinet and a constant temperature mechanism. The constant temperature mechanism is installed inside the medicine storage cabinet, and a heat preservation component is installed inside the cabinet. A reheating component is installed on the outside of the heat preservation component. This utility model utilizes the heat preservation component to allow the ointment to be removed by pulling the corresponding storage box along a fixed frame as needed. Moving the storage box individually reduces the contact area with air, effectively reducing temperature fluctuations inside the medicine storage cabinet each time the ointment is removed. The reset component ensures that pulling out the storage box moves the connecting rod along the movable groove, compressing and deforming the reset spring. When the storage box is released, the reset spring pushes the connecting rod, moving the storage box back to its initial position for convenient use.
Owner:HEILONGJIANG TIANCHEN PHARM CO LTD

Compound ketoconazole cream and preparation method thereof

The invention provides a preparation method of compound ketoconazole cream, and relates to the technical field of external ointment. The ketoconazole emulsifiable paste comprises the following components in percentage by mass: 0.1-2% of ketoconazole, 2-5% of camphor oil and 10-15% of a traditional Chinese medicine extract, and 20-30% of a compound emulsifier. The components comprise, by weight, 10-20% of a humectant, 0.1-0.2% of a preservative, 0.1-0.3% of an antioxidant, and the balance of water; the traditional Chinese medicine extract is a mixed alcohol extract of wormwood, dandelion and mint; the compound emulsifier is formed by mixing hexadecyl trimethyl ammonium bromide and lauryl sodium sulfate. The compound ketoconazole emulsifiable paste prepared by the invention does not contain glucocorticoid, and through the synergistic effect of the Chinese herbal medicine extract, ketoconazole and camphor oil, the drug effect can be remarkably improved, so that the radical treatment of diseases is realized. The compound ketoconazole cream disclosed by the invention does not irritate skin and has no side reaction.
Owner:JIANGXI ZHONGZEYUAN PHARMACEUTICAL TECHNOLOGY CO LTD

Traditional Chinese medicine composition for treating wound ulcer and preparation method thereof

The invention discloses a traditional Chinese medicine composition for treating wound ulcer and a preparation method thereof, and belongs to the technical field of traditional Chinese medicines. The prescription is composed of 5-15 parts of slender gouania root, 5-10 parts of maggot, 0.01-0.5 part of venenum bufonis, 5-10 parts of American cockroach, 5-15 parts of abelmoschus manihot, 3-9 parts of rheum officinale, 1-5 parts of safflower and 5-15 parts of fructus chebulae, the dosage form is external ointment, powder, oil, liquid preparation and the like, the traditional Chinese medicine composition is remarkable in curative effect, the cure rate can reach 85% or above after 2 months of treatment, the average healing time is shortened by 40 days or above, safety is high, and the traditional Chinese medicine composition is suitable for clinical application. The traditional Chinese medicine composition is suitable for chronic intractable wound ulcer such as diabetic foot ulcer, and the problem of poor treatment effect in the prior art is solved.
Owner:CHANGSHA OUBANG BIOTECHNOLOGY CO LTD

A traditional Chinese medicine composition for tonifying kidney, activating blood and nourishing fetus

The application discloses a traditional Chinese medicine composition for tonifying kidney, promoting blood circulation and nourishing fetus, which comprises an external ointment and an internal medicine, wherein the external ointment is prepared from specific proportion of taxilli herba, rhizoma discontinu, semen euryales, radix codonopsis, rhizoma atractylodis, fried lentil, rhizoma dioscoreae, amomum villosum, radix puerariae, dendrobium, angelica sinensis, salvia miltiorrhiza, cortex moutan, chuanxiong rhizome, radix astragali, frankincense, myrrh, radix angelicae, and zanthoxylum bungeanum; and the internal medicine is prepared from specific proportion of semen euryales, cornus officinalis, ligustrum lucidum, eucommia ulmoides, taxilli herba, fried radix atractylodis, rhizoma discontinu, amomum villosum, radix codonopsis, rhizoma cimicifugae, herba agastache, radix puerariae, dendrobium, angelica sinensis, salvia miltiorrhiza, cortex moutan, radix notoginseng and radix ophiopogonis. The application can treat the root and branch by oral administration and external application on blood sea, yinlingquan and san yin jiao, has the effects of benefiting qi and blood, nourishing yin and promoting blood circulation, and can improve the blood supply of uterus during pregnancy, and is used for treating the symptoms of vaginal bleeding during pregnancy, slow embryo development, less moss and fine and smooth pulse caused by deficiency of qi and blood, deficiency of kidney yin and stagnation of qi and blood.
Owner:MATERNAL & CHILD HEALTH HOSPITAL OF HUBEI PROVINCE

Houttuynia cordata thunb. nose-coating paste, preparation method and application

The present application relates to the technical field of traditional Chinese medicine, and particularly relates to a houttuynia cordata coated nose ointment, a preparation method and application. The houttuynia cordata coated nose ointment comprises the following components in percentage by weight: 5-10% of houttuynia cordata extract, 80-90% of a vaseline-lanolin compound base, 1-3% of a penetration enhancer, and 0.1-0.5% of an antioxidant. The mass ratio of vaseline to lanolin in the vaseline-lanolin compound base is 7:3. The present application uses the houttuynia cordata extract as a core effective component, and is prepared by matching the vaseline-lanolin compound base, the penetration enhancer and the antioxidant in a specific proportion to form an external ointment, which can accurately solve the problems of drug resistance, obvious adverse reactions, poor dosage form adaptability and insufficient targeting in the treatment of existing sinusitis.
Owner:CHONGQING YONGCHUAN DISTRICT HOSPITAL OF TRADITIONAL CHINESE MEDICINE

An external ointment for burns and scalds and its preparation method

ActiveCN118178521BGlycerolBurns/scalds
The application discloses an external ointment for treating burns and scalds and a preparation method thereof. The external ointment comprises a base and a traditional Chinese medicine composition super-micron powder. The traditional Chinese medicine composition comprises the following components in parts by weight: Huanglian 1-5 parts, Huangqi 1-5 parts, Huangbo 1-5 parts, Dilong 0.5-1.5 parts, Dajiugen 1-5 parts and Xianrenzong 1-5 parts. The base is an oil-in-water base and comprises the following components in parts by weight: glycerol 1-9 parts, triethanolamine 0.1-0.5 parts, 1,2-propylene glycol 0.5-5 parts, ethyl parahydroxybenzoate 0.01-0.3 parts, water 10-50 parts, white beeswax 0.2-5 parts, lanolin 1-10 parts, stearic acid 2-20 parts and glycerol monostearate 1-10 parts. The traditional Chinese medicine composition uses Huanglian, Huangqi and Huangbo as main effective components, and is combined with Dilong, Xianrenzong and Dajiugen, so that the traditional Chinese medicine composition has the effects of clearing heat and toxic material, dispersing blood stasis and eliminating muscle knot in the process of repairing burn and scald wound surface.
Owner:CHINA AGRI UNIV

External ointment for treating eczema and preparation method thereof

The invention relates to an external ointment for treating eczema and a preparation method thereof. Sinkiang lithospermum erythrorhizon, radix sophorae flavescentis and cortex phellodendri are used as monarch drugs. Sinkiang lithospermum erythrorhizon clears heat, cools blood, detoxifies and promotes eruption, radix sophorae flavescentis and cortex phellodendri clear heat, eliminate dampness, dispel wind and arrest itching, and directly act on the root of eczema damp-heat toxin. Salvia miltiorrhiza, radix rehmanniae, radix paeoniae rubra, cortex moutan and purslane are used as ministerial drugs. The radix rehmanniae, the radix paeoniae rubra and the cortex moutan are used for cooling blood and clearing heat, and the purslane is used for clearing away heat and toxic materials and assisting the monarch drug to enhance the effects of clearing heat and cooling blood, and dispersing blood stasis and relieving itching. Cynanchum paniculatum, radix saposhnikoviae, radix angelicae, platycodon grandiflorum, sanguisorba officinalis and cortex dictamni are used as adjuvant drugs. Radix cynanchi paniculati and divaricate saposhnikovia root dispel wind and arrest itching, radix angelicae dahuricae eliminates dampness and arrest itching, platycodon grandiflorum carries medicine and is transdermal, sanguisorba officinalis is used for cooling blood and astringing, cortex dictamni is used for clearing heat and eliminating dampness, and monarch and ministerial medicines are jointly assisted in A trace amount of dexamethasone is used for assisting rapid anti-inflammation, uncomfortable symptoms such as skin itch, papule and scabbing caused by eczema can be relieved, and instant pain of a patient can be rapidly relieved; skin barrier damage caused by eczema is improved, and normal physiological function recovery of skin is promoted.
Owner:芦婷婷

Traditional Chinese medicine preparation for treating burns and scalds as well as preparation method and use method of traditional Chinese medicine preparation

The invention discloses a traditional Chinese medicine preparation for treating burns and scalds and a preparation and use method thereof, and belongs to the technical field of traditional Chinese medicine preparations for burns and scalds. The preparation comprises 27 medicines such as dragon's blood, garden burnet, golden cypress, coptis chinensis, beewax and aloe, and has the effects of resisting bacteria and diminishing inflammation, clearing away heat and toxic materials, relieving pain and preventing corrosion, promoting blood circulation to remove blood stasis, moistening skin and relieving itching. Through clinical trials for many years, the traditional Chinese medicine is obvious in effect and free of toxic and side effects, and promises that scars are not left on second-degree scalds. The use of the test preparation completely adapts to the awareness of people to the scald ointment, ensures that the basic risks of secondary damage and cross infection do not occur after scald treatment, fundamentally solves the negative effects caused by unreasonable use, and is affirmed by medical workers and experts. As a common necessary external ointment, the preparation plays a key role in the treatment process of emergency treatment, and the efficacy, the action, the medicinal components, the use method, the main application and the effect of the scald ointment are introduced in detail, so that a patient can better understand and use the product.
Owner:李思媛

Mupirocin ointment composition, preparation method, application and related products

The invention provides a mupirocin ointment composition, a preparation method, application and related products, and belongs to the technical field of external ointment. The mupirocin ointment composition provided by the invention is prepared from the following components in parts by weight: 0.5 to 5.0 parts of mupirocin, 58 to 68 parts of liquid polyethylene glycol, 20 to 36 parts of solid polyethylene glycol, 1.07 to 5.07 parts of borneol, 0.30 to 0.82 part of quercetin, 0.41 to 0.93 part of S-acetyl-L-glutathione and 0.7 to 3.2 parts of urea. The mupirocin ointment composition can be used for preparing the mupirocin ointment, and compared with the prior art, the mupirocin ointment has higher transdermal speed, intradermal retention volume and drug utilization rate, and is high in storage stability and good in biocompatibility.
Owner:JIANGXI PRIER PHARM CO LTD

Preparation method and application of pressure-sensitive ointment for treating perianal dermatitis

The invention provides a preparation method and application of a pressure-sensitive ointment for treating perianal dermatitis, and the pressure-sensitive ointment is mainly prepared by mixing chitosan and an organic ester compound at high temperature to form a hydrogen bond complex and then mixing the hydrogen bond complex with a glucocorticoid drug and an additive. The invention also provides application of the pressure-sensitive ointment in preparation of drugs for treating perianal skin inflammation (such as perianal eczema, pruritus ani and the like). Chitosan and organic ester compounds interact to form a hydrogen bond complex, and then medicines and other additives are added, so that the pressure-sensitive ointment is prepared. The ointment has the characteristic of pressure sensitivity, and can well balance the adhesiveness and fluidity of the external ointment on the wrinkled skin. The drug carrier can be used for loading glucocorticoid drugs, is convenient for patients to use, improves the percutaneous bioavailability of the drugs, and better realizes the treatment of perianal dermatitis.
Owner:GUIZHOU MEDICAL UNIV

External plaster for treating lymphoma

The invention discloses an external plaster for treating lymphoma, which is prepared from the following materials in parts by weight: 10-20 parts of aconitum carmichaeli, 5-20 parts of moutan bark, 15-30 parts of sculellaria barbata, 10-25 parts of astragalus membranaceus, 8-15 parts of semen momordicae, 5-10 parts of musk, 10-25 parts of oldenlandia diffusa, 5-10 parts of cantharides, 8-12 parts of centipede, 3-10 parts of borneol, 5-10 parts of gecko and a mixed adhesive. Comprising the steps of grinding, soaking, heating, stirring and precipitating. The external plaster for treating lymphoma prepared by the method has the characteristics of low preparation cost and obvious targeted treatment effect, and plays a great role in traditional medical treatment for patients.
Owner:HUNAN QITIETANG PHARMACEUTICAL TECHNOLOGY CO LTD

External heat-clearing traditional Chinese medicine ointment for improving targeted therapy skin tolerance

The invention belongs to the field of traditional Chinese medicine external ointment, and discloses heat-clearing traditional Chinese medicine external ointment for improving targeted therapy skin tolerance, the ointment is composed of traditional Chinese medicine active components and a medicinal matrix, the traditional Chinese medicine active components comprise the following raw materials in parts by weight: 20-40 parts of scutellaria baicalensis, 15-35 parts of radix sophorae flavescentis, 15-30 parts of cortex dictamni, 25-45 parts of purslane, 10-25 parts of fructus kochiae, 10-25 parts of fructus cnidii, 12-28 parts of sanguisorba officinalis and 8-18 parts of mint; the medicinal matrix comprises an oil-phase matrix, a water-phase matrix, an emulsifier and a humectant, the traditional Chinese medicine active components account for 20-40% of the total mass of the ointment, the oil-phase matrix accounts for 25-45%, the water-phase matrix accounts for 15-30%, the emulsifier accounts for 3-8%, and the humectant accounts for 2-6%; according to the technical scheme, generation of EGFRIs related skin adverse reactions can be inhibited from the source, different types of skin symptoms can be relieved in a targeted mode, the tolerance of the skin of a patient to targeted therapy is comprehensively improved, and the traditional Chinese medicine composition is good in clinical use performance, convenient to use, free of adverse reactions and high in use safety.
Owner:THE FIRST AFFILIATED HOSPITAL OF HEBEI NORTH UNIV

Traditional Chinese medicine composition for warming and strengthening knees, knee protector using the same and preparation process thereof

This invention provides a traditional Chinese medicine composition for warming and strengthening the knees, a knee brace using the same composition, and a preparation process thereof, relating to the field of pharmaceutical technology. The composition is made from the following raw materials in parts by weight: 25 parts of dried mugwort leaves, 10 parts of white chrysanthemum, 10 parts of longan shell, and 5 parts of Sichuan pepper. The knee brace using the traditional Chinese medicine composition for warming and strengthening the knees includes a knee brace body and a drug-containing portion located at the knee joint area of ​​the knee brace body. The drug-containing portion is filled with powdered traditional Chinese medicine made from the composition for warming and strengthening the knees. The traditional Chinese medicine composition for warming and strengthening the knees provided by this invention solves the problems of significant side effects, cumbersome usage steps, and difficulty in normal activity during use of existing oral preparations, external ointments, and soaking preparations; it can meet the daily maintenance needs of knee joint protection against cold coagulation.
Owner:SHANGHAI SHENHUIYUAN ENTERPRISE DEVELOPMENT CO LTD

External ointment for traumatic injury, fracture and ostealgia and preparation method thereof

The invention relates to the field of traditional Chinese pharmacology, and discloses an external ointment for traumatic injury, fracture and ostealgia and a preparation method thereof. The traditional Chinese medicine composition comprises the following components: herba lycopi, fructus aurantii, sappan wood, rhizoma atractylodis, rheum officinale, rhizoma atractylodis macrocephalae, frankincense, myrrh, rhizoma cyperi, peach kernels, pericarpium citri reticulatae viride, radix linderae, fructus psoraleae, radix paeoniae rubra, polygonum cuspidatum, rhizoma zingiberis, scutellaria baicalensis, safflower carthamus, lumbricus, eucommia ulmoides, radix achyranthis bidentatae, cinnamon, rhizoma sparganii, curcuma zedoary, asarum, cortex phellodendri, fossil fragments, rosa laevigata michx roots, radix curcumae, amber, native copper, pseudo-ginseng, resina draconis, cinnabar, catechu, red halloysite, chingma abutilon seeds, pollen typhae, clove, corydalis tuber and artemisia anomala. , stalactite, cuttlebone, saussurea involucrata and embelia laeta root. The traditional Chinese medicine composition has the effects of relieving swelling and pain, dispelling wind and eliminating dampness on rheumatism ostalgia, arthralgia and lumbocrural pain diseases such as tenosynovitis, frozen shoulder, knee osteoarthritis, cervical spondylosis, lumbar muscle degeneration, lumbar disc herniation and stiff neck; the effects of promoting blood circulation to remove blood stasis and relieving swelling and pain are also achieved on trauma such as traumatic injuries and fractures.
Owner:北流市保金地产中草药店(个体工商户)

Specially-made hot ointment

The invention relates to the technical field of traditional Chinese medicines, in particular to a special hot ointment, which comprises special lime water prepared by a specific process and aged tea oil, and the special lime water and the aged tea oil are compatible according to a volume ratio of 2: 1 to form a milk white viscous cream medicament. The preparation method comprises the steps of collecting natural water, refining lime water, aging old tea oil, emulsifying ointment and the like, strictly follows a traditional processing technology and is combined with a modern preparation technology. The ointment has the effects of rapidly easing pain, reducing exudate, promoting deep tissue repair and preventing scar formation, and is suitable for treating wounds of mild to moderate burns and scalds. The invention further provides a quality control method, it is ensured that the product is safe and efficient, and an external ointment selection integrating traditional intelligence and modern technology is provided for treatment of burns and scalds.
Owner:SHENZHEN ECHIZEN CREATIVE ELECTRONIC TECHNOLOGY CO LTD

Formula and production process of herpes zoster external ointment for treating herpes zoster

The invention relates to the technical field of traditional Chinese medicines, in particular to a formula and a production process of an external ointment for treating herpes zoster. The traditional Chinese medicine is prepared from the following raw materials in parts by weight: rheum officinale, radices trichosanthis, pearl powder, coptis chinensis, golden cypress, cottonrose hibiscus leaves, herba lycopi leaves, bulbus fritillariae cirrhosae, radix paeoniae rubra, liquorice, frankincense, myrrh, calculus bovis, borneol, realgar, purslane, impatiens balsamina and vaseline. After the medicines are combined, a synergistic effect can be generated. The traditional Chinese medicine is applied to the affected part one to two times a day, can quickly eliminate heat, reduce swelling, relieve pain, cool and activate blood, diffuse and store heat, detoxify and recover dryness, and can be cured in 5-10 days. The traditional Chinese medicine is easy to obtain raw materials, simple in process, convenient to use, less in pain, safe and reliable, and has the effective rate of 100% and the cure rate of 95%. The external ointment for herpes zoster has good market prospect and development value, and is worthy of popularization.
Owner:YUNNAN UNIVERSITY OF CHINESE MEDICINE