20 results about "Gentiana" patented technology

The invention provides a lipid-lowering traditional Chinese medicine composition and extract as well as a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines. The lipid-lowering traditional Chinese medicine composition is prepared from the following raw materials: rhizoma cyperi and radix gentianae. The invention further provides an extract of the lipid-lowering traditional Chinese medicine composition. The extract is obtained by mixing rhizoma cyperi and radix gentianae and then co-extracting. The composition or the extract can be used for preparing medicines for preventing and / or treating hyperlipemia, and can be used for improving lipid metabolism disorder of liver cells and reducing the content of triglyceride and total cholesterol in the liver cells.

The invention belongs to the technical field of external traditional Chinese medicine ointment, and particularly relates to traditional Chinese medicine ointment for treating arthralgia. The traditional Chinese medicine composition specifically comprises the following raw materials: ground beetles, saline scorpions, centipedes, leeches, earthworms, silkworm larva, cantharides, rhizoma drynariae, shelled semen strychni, corydalis amabilis, peach kernels, saffron crocus, notopterygium roots, gentiana macrophylla, trogopterus dung, buttercup, cottonrose hibiscus leaves, borneol and musk. According to the invention, synergy of insect drugs and botanical drugs for dispelling wind and promoting blood circulation is taken as a core, and the composition is adapted to complex syndromes of arthralgia. The problems of component inactivation, degradation and insufficient extraction are avoided by adopting split-phase extraction; controlled-release microcapsules are separately arranged for high-risk groups such as cantharides to reduce stimulation and slow release, borneol and musk are included to increase stability, and infiltration promotion and slow release are complementary; an oil-water system is constructed by the cream matrix, and the cream has sealing performance, spreadability and residence performance and is suitable for external massage.

The application provides a device for soil removal and root separation of gentiana root system and a working method thereof. The device comprises a feeding port, a sliding hammer impact mechanism, an eccentric vibrating conveyor belt, an extrusion roller pair, a main motor, a turnover plate, a flexible rubber belt beating mechanism, a rack, a concave-convex roller system combing mechanism and a collecting tank. The eccentric vibrating conveyor belt comprises an upper eccentric vibrating conveyor belt and a lower eccentric vibrating conveyor belt. The extrusion roller pair comprises an inclined extrusion roller pair and a horizontal extrusion roller pair connected with each other. The sliding hammer impact mechanism, the flexible rubber belt beating mechanism and the eccentric vibrating conveyor belt realize the separation of the root system and the soil through knocking, beating and vibrating. The extrusion roller pair and the concave-convex roller system combing mechanism damage the net structure formed by the entanglement of the root systems of different plants through extrusion and pulling, so that the root separation effect of different plants is realized.

The invention relates to the technical field of oral care, and provides Chinese herbal medicine plant toothpaste and a preparation method thereof.The toothpaste is composed of wild mint, paris polyphylla roots, pseudo-ginseng roots, dandelion, radix paeoniae alba, moutan bark, honeysuckle, wild chrysanthemum flowers, gentiana rigescens, verbena, herba lycopi, gypsum, calculus bovis and matrix auxiliary materials, and core raw materials are Yunnan genuine medicinal materials. The preparation process combining segmented extraction and nitrogen protection superfine grinding is adopted, effective components of Chinese herbal medicines are fully released, all the components have a synergistic effect, and the toothpaste has the comprehensive effects of preventing oral ulcer, whitening, removing halitosis, strengthening teeth, diminishing inflammation, killing bacteria, reducing stomach fire, stopping bleeding and strengthening the oral cavity; particularly, the effects of inhibiting oral pathogenic bacteria, repairing gingival injury and removing dental plaque are obvious. The product is controllable in process, high in stability, mild and non-irritant, can comprehensively solve various potential oral problems, and meets the high-quality oral care requirements of consumers.

The invention discloses an external nursing cream containing white muscardine silkworm and gentiana macrophylla and a preparation method thereof, the nursing cream takes white muscardine silkworm and gentiana macrophylla as main raw materials, the main raw materials are extracted by ethanol with the concentration of 20-99%, and the ethanol can be edible wine, health care medicinal liquor or medical ethanol; and the finished product is mild for external use after being blended by a matrix, and the irritation is controllable. Auxiliary materials such as artificial musk, ground beeltle, mirabilite, myrrh and angelica sinensis can be selectively added, and the ointment is prepared by extracting, concentrating and adding an external matrix. The invention has the advantages of simple and mild formula, flexible and simple process, easily available raw materials and wide application range, and is suitable for daily external skin care.

To provide a skin care preparation which is derived from a natural product, is excellent in biological safety, and exhibits functions of preventing or improving skin roughness, improving the transparency of the skin, and suppressing cell aging by suppressing the secretion of inflammatory substances (cytokine and chemokine) in the skin.SOLUTION: An extract of Gentiana lutea belonging to the genus Gentiana of the family Gentianaceae and an extract of Bletilla striata belonging to the genus Bletilla of the family Orchidaceae are used as active ingredients for suppressing the secretion of inflammatory factor (cytokine and chemokine).SELECTED DRAWING: None

The application discloses a gentiana rigescens endophytic Streptomyces coelicoflavus and application thereof, and belongs to the technical field of microorganisms. The application relates to the gentiana rigescens endophytic Streptomyces coelicoflavus, which is preserved in the China General Microbiological Culture Collection Center on September 23, 2022, and the strain preservation name is MEP0301, and the preservation number is CGMCC No. 25778. The strain can significantly promote the increase of the total flavone content and the total triterpene content in the gentiana rigescens, and can be artificially cultured, is genetically stable, and is easy to be produced on a large scale. The strain can be used for artificial planting of the gentiana rigescens, can effectively improve the quality of medicinal materials, and has a good application prospect.

The invention belongs to the technical field of traditional Chinese medicine preparations, and discloses a traditional Chinese medicine composition capable of regulating spleen and kidney to promote children to grow tall as well as a preparation method and application thereof. The traditional Chinese medicine composition is prepared from rhizoma anemarrhenae, astragalus membranaceus, coptis chinensis, radix curcumae, liquorice, felwort, fructus alpiniae oxyphyllae, prepared rhizoma polygonati, acanthopanax, fructus psoraleae, semen cuscutae, glossy privet fruit, cistanche, prepared rhizoma cibotii, radix rehmanniae recen, prepared rehmannia root, agastache rugosus, schisandra chinensis, pericarpium citri reticulatae and poria cocos. The preparation method comprises the following steps: S1, preparing and pretreating raw materials: weighing the raw materials, cleaning, selecting and washing the raw materials, and then crushing the raw materials; s2, concentration and extraction: firstly decocting the pretreated raw materials, then separating, and finally concentrating to obtain the required traditional Chinese medicine composition. The traditional Chinese medicine composition can improve the problems of picky eating, anorexia, dyspepsia, sallow complexion, difficulty in falling asleep, night crying, dysphoria, irritability and the like, and can effectively promote children to grow tall.

The present application relates to a kind of multi-effect herbaceous plant composite soothing repair composition and its preparation method, belong to the cosmetic technical field.The present application is by mixing glacial low deuterium water and superoxide dismutase to obtain A component, add D component (specific proportion nicotinamide mononucleotide (NMN) and modified hyaluronic acid microsphere) by the special interaction of the two with low deuterium water, form "triple synergistic carrier system", significantly improve the penetration and stability of active substance;B component is to mix hydroxyl asiaticoside and humectant.Meanwhile, the composite extract prepared by mixing the extract of radix stephaniae tetrandrae, the extract of gentiana and the extract of piper methysticum is C component, after mixing with A, B, D each component, low deuterium water can well carry the active ingredient in plant extract, hydroxyl asiaticoside and humectant in B component are mixed, can give full play to the moisturizing effect.The composition obtained after mixing A, B, C, D component has excellent soothing repair effect.

The application discloses a kind of synchronous rapid detection and quality evaluation method of gentiana officinalis medicinal materials multiple components, belong to traditional Chinese medicine analysis and quality control technical field.The present application is directed to the defects that the comprehensive detection and analysis efficiency are difficult to be considered and the specificity of base source identification is insufficient in prior art, adopts phenyl-hexyl silane bonded silica gel chromatographic column, with acetonitrile-water as mobile phase, by specific three-stage gradient elution, in 20 minutes, the three major active ingredients of nucleosides, iridoid glycosides, flavonoids in gentiana are separated synchronously, the fingerprint containing 17 common peaks is constructed, the origin identification of multiple index component quantitative determination and gentiana and hard gentiana can be completed synchronously.The precision, stability and repeatability of the method are good, the detection efficiency and quality control comprehensiveness are greatly improved, and the method is suitable for industrialized batch rapid quality inspection of gentiana officinalis medicinal materials.

The invention discloses a method for extracting polysaccharide and bitter glycoside from radix gentianae, which comprises the following steps: by taking dry radix gentianae as a raw material, crushing the radix gentianae, adding an extraction solvent water, regulating the pH value by using sulfuric acid, performing ultrasonic extraction, filtering, regulating the pH value of an extracting solution by using ammonia water, centrifuging, concentrating, adding a polyethylene glycol aqueous solution into an extract, regulating the pH value by using ammonia water, performing ultrasonic extraction, and filtering to obtain the polysaccharide and bitter glycoside. And carrying out centrifugation, phase separation, ultrafiltration, nanofiltration and other steps to obtain an extract containing gentian polysaccharide and bitter glycoside. According to the method, polysaccharide and bitter glycoside are synchronously extracted and purified, the efficiency is high, no organic solvent is adopted, a large amount of energy consumption can be saved, production equipment has no anti-explosion requirement, the production process is simple and easy to control, the method has the advantages of being green, environmentally friendly, safe and efficient, and the obtained extract is high in purity.

The application relates to the cosmetic technical field, and particularly discloses a composition for micro-ecological balance and circadian rhythm repair and lightening and application. The composition for micro-ecological balance and circadian rhythm repair and lightening comprises the following components in mass percentage: glycyrrhiza glabra root extract 0.001%-1%, olea europaea leaf extract 0.1%-5%, hydraena elongata extract 0.1%-2%, gentiana rigescens 0.5%-3%, inulin 0.1%-5%, tripeptide-3 0.001%-0.01%, jasminum nudiflorum extract 0.5%-2%, and the balance is water. The composition has the advantages of systematically solving multiple problems such as skin redness, dullness and rhythm disorder.

The application discloses a traditional Chinese medicine composition for treating lumbar pain caused by diseases of the motor system and application thereof, and relates to the technical field of traditional Chinese medicines.The traditional Chinese medicine composition comprises yam, dogwood, prepared rehmannia, cassia twig, radix angelicae pubescentis, raw eucommia, rhizoma anemarrhenae, drynaria, frankincense, myrrh, chuanxiong, angelica sinensis, cyperus rotundus, achyranthes bidentata, amomum villosum, tangerine peel, gentiana, polygala, and licorice.The traditional Chinese medicine composition has the effects of tonifying liver and kidney, strengthening bones and muscles, promoting blood circulation to remove meridian obstruction, and relieving swelling and pain, and can be used for treating lumbar pain caused by various diseases of the motor system, such as lumbar hyperosteogeny, intervertebral disc herniation, lumbar vertebra hypertrophy, spinal stenosis, lumbar fracture, spinal canal tumor, acute and chronic trauma or strain of the lumbar region, lumbar muscle strain, and ankylosing spondylitis, and has outstanding curative effects on acute and chronic lumbar pain.

The present application relates to a kind of mild moisturizing soothing composition and its application, the composition includes the following weight parts of component: 5-10 parts of lactobacillus / fermentation product of algal extract, 2-5 parts of capparis zeylanica fruit extract, 3-5 parts of olive fruit oil and 10-15 parts of schisandra fruit extract-gentiana root extract, four synergistically improve the moisturizing soothing effect of composition.The schisandra fruit extract-gentiana root extract of the present application is biotransformed and synergistically metabolized by compound fermentation bacteria, significantly improves the utilization rate of active ingredients in schisandra fruit extract and gentiana root extract, and expands its efficacy range, can play the role of regulating inflammatory response, reinforcing skin barrier, solving the problem of eczema skin barrier, reducing scratching skin stinging discomfort, reducing eczema recurrence, solving the problem of dry peeling caused by indoor and outdoor temperature difference, dry area, reducing water loss and antioxidant damage and other multiple effects.

The invention discloses a formula and a preparation method of rheumatoid arthritis traditional Chinese medicine granules for improving joint swelling and pain. The granules are prepared from twelve traditional Chinese medicines including caulis sinomenii, tripterygium wilfordii (prepared), radix paeoniae alba, astragalus membranaceus, angelica sinensis, caulis spatholobi, radix clematidis, gentiana macrophylla, radix stephaniae tetrandrae, rhizoma smilacis glabrae, liquorice and rhizoma corydalis according to specific compatibility of monarch, minister, assistant and guide in parts by weight. The preparation method adopts a graded extraction process, and comprises the following steps: decocting partial medicinal materials with water, performing ethanol reflux extraction on partial medicinal materials, independently extracting astragalus membranaceus, combining and concentrating, and mixing and granulating with liquorice fine powder. The granules are scientific in formula and reasonable in process, the obtained granules are stable in quality and convenient to take, experiments prove that the granules have remarkable anti-inflammatory, detumescence, analgesia and immune regulation effects, and the granules are suitable for improving and treating symptoms such as joint swelling and pain, morning stiffness and limited activity caused by rheumatoid arthritis.

The invention discloses a method, a kit and a server for identifying species of a gentian medicinal material in a mixture. According to the invention, the optimized lysate formula significantly improves the quality of DNA extracted from a complex mixture. The reducibility of the lysate is enhanced by increasing the content of beta-mercaptoethanol, and the DNA is effectively prevented from being oxidized and damaged in the extraction process; the added protease K strengthens the digestive ability to protein, and reduces the wrapping and pollution of protein impurities to DNA (Deoxyribose Nucleic Acid); due to the addition of PVP, polyphenol substances in the mixture can be adsorbed, and degradation caused by combination of the polyphenol substances and DNA is avoided; the lysate can better cope with various interference components in a complex matrix due to the moderately improved CTAB concentration and salt concentration and stronger metal ion chelating ability, and meanwhile, the pH value of the solution is stabilized by the adjusted Tris-HCl concentration, so that the DNA is kept stable in the extraction process. Due to the improvements, the purity and the integrity of the extracted DNA are obviously improved, and a high-quality template is provided for subsequent species identification.

The application discloses an arabinogalacturonan polysaccharide, the polysaccharide structural characteristics of which are that monosaccharide composition is mainly arabinose and galacturonic acid, the molecular weight is 23 kDa, the connection mode is (1→3, 5)-alpha-Araf-(1→3, 5)-alpha-Araf-(1→3, 4)-alpha-GalpA-(6-OMe)-(1→ as the main chain, and the arabinose branch, HG domain and terminal galacturonic acid are contained. The preparation method comprises the following steps: pulverizing small gentiana powder, water extraction and alcohol precipitation, removing protein, removing small molecules and utilizing weak anion exchange resin adsorption, and then eluting with a salt solution with a concentration of 0.1 M to obtain high-purity small gentiana polysaccharide. The arabinogalacturonan polysaccharide has good antioxidant activity and immunomodulatory activity, has application value for treating various diseases, and has clear structure and good activity, thereby laying a foundation for developing the medicinal value of the small gentiana polysaccharide.

The application relates to the technical field of traditional Chinese medicines, and provides a traditional Chinese medicine composition for moistening intestines and relieving constipation as well as a preparation method and application of the traditional Chinese medicine composition. Raw material components of the traditional Chinese medicine composition contain, in weight parts, 23-42 weight parts of donkey-hide gelatin beads, 23-42 weight parts of siler, 5-8 weight parts of nard, 5-8 weight parts of gentiana, 11-21 weight parts of dried orange peel, 11-21 weight parts of angelica, 11-21 weight parts of bitter orange, 11-21 weight parts of cooked rhubarb, 5-8 weight parts of sloe, 11-21 weight parts of hemp seeds and 5-8 weight parts of schizonepeta. The traditional Chinese medicine composition provided by the application can produce a significant synergistic effect among the components, so that the purposes of moistening intestines, relieving constipation and treating constipation are achieved; and the traditional Chinese medicine composition has the effects of mild drug efficacy, remarkable curative effect, high safety and the like.

The invention discloses a traditional Chinese medicine composition for reducing the uric acid level and a preparation method and device thereof, and belongs to the technical field of traditional Chinese medicine composition preparation. Comprising the following raw materials in parts by weight: 5-10g of coptis chinensis, 10-20g of herba cepbalanoplosis segeti, 5-20g of cortex erythrinae, 5-20g of pericarpium citri reticulatae, 6-12g of pinellia ternate, 6-30g of poria cocos, 10-25g of gentiana macrophylla, 10-30g of yam rhizome and 3-9g of liquorice. The problems that in the prior art, the mixing effect and the residue filtering effect are common during traditional Chinese medicine liquid process treatment are solved, traditional Chinese medicine liquid is evenly heated under the action of a heating wire and a stirring mechanism, the mixing effect is good, a stirring shaft and a rotating shaft are connected through a coupler, and the stirring shaft can be driven to rotate together during rotating shaft transmission; the mixed liquid medicine is filtered by the filter residue mechanism and the filter screen II, so that the effective concentration of the liquid medicine is ensured, and the high uric acid treatment device has a remarkable treatment effect on high uric acid and is worthy of wide popularization.

This invention belongs to the field of biocontrol technology of plant endophytic fungi and their metabolites, specifically relating to a growth-promoting and disease-resistant fermentation broth of a gentian endophytic fungus, its preparation method, and its application. The fermentation broth of this invention is prepared by activating and fermenting the endophytic fungus *Trichoderma* sp. 3711 from gentian. Antibacterial and growth-promoting experiments have demonstrated that the fermentation broth of this invention has significant broad-spectrum antimicrobial effects against plant pathogens and promotes plant (especially crop) growth. Furthermore, the preparation method of the fermentation broth based on *Trichoderma* sp. 3711 isolated from gentian is simple, inexpensive, and has good economic value and broad market prospects.