80 results about "Uric acid excretion" patented technology

The invention discloses a soda water beverage and a preparation method thereof. The soda water beverage comprises raw materials in parts by weight added to every 1,000 kg of water as follows: 100-300 g of sodium bicarbonate, 40-120 g of acesulfame, 15-45 g of magnesium sulfate, 1-3 g of potassium chloride and 75-225 g of lemon essence, and the PH value of the soda water beverage is 7.1-8.5. The technological process of the soda water beverage comprises following steps: (1), equipment cleaning and sterilization; (2), raw water treatment; (3), blending; (4), soda water sterilization; (5), bottle and bottle cap disinfection; (6), filling and packaging. The soda water beverage is helpful to relieve symptoms such as indigestion, constipation and the like and is helpful to uric acid excretion, thereby having prevention and treatment functions on hyperuricemia or gout; in hot summer, sodium in the soda water can supplement sodium lost through sweat volatilization, and the soda water beverage is quite popular fashion drink; primary and secondary reverse osmosis devices are adopted for an efficient desalination technology, impurities such as inorganic ions, bacteria, viruses, metal ion organic matters, colloids and the like in raw water can be removed, high-quality highly-pure water is obtained, the operating cost is saved, and environmental protection is facilitated.

The invention relates to a drug for treating purine metabolic disorder disease, provides a flavonoids compound represented by the formula (I) and a modified derivative thereof, and a use in inhibition of xanthine oxidase activity and promotion of uric acid excretion function, wherein R1, R2 and R3 independently represent -H or monosaccharide residues, and R4 represents -H or -OH. In particular, the drug is used for treating purine metabolic disorder disease, and can be used for treating hyperuricemia and related diseases and reducing a individual serum UA level; the drug is used for treating hyperuricemia; the drug is used for treating the related diseases, such as for treating gouty arthritis and arthrophlogosis caused by hyperuricemia, and for treating chronic interstitial nephritis, kidney stones and the like caused by hyperuricemia. The drug has the advantages of natural chemical structure, safety, low toxicity, rapid curative effect and fewer side effects. (I).

The invention belongs to the technical field of food preparation, and particularly relates to a fructus gardeniae and poria cocos composite beverage and a preparation method thereof. The fructus gardeniae and poria cocos composite beverage is prepared from the following raw materials of fructus gardeniae, poria cocos, villous amomum fruits, chicory, mulberry leaves, corn stigma, polished glutinousrice, Chinese yams, cherries, carrots, celery, papayas, lemons, potassium citrate, sodium citrate, water and lactic acid bacteria. The fructus gardeniae and poria cocos composite beverage is suitablefor patients suffering from hyperuricaemia and gout, in multiple manners for invigorating spleen, eliminating dampness, promoting drainage of uric acid, reducing uric acid and the like, the blood uric acid level can be reduced in multiple target points, and the breaking out of the gout can be alleviated.

The invention provides a medicine for reducing the uric acid. The medicine comprises the following components in percent by weight: 10%-40% of catechinic acid, 10%-20% of tea pigment, 10%-20% of tea compound sugar, 5%-20% of theanine, 5%-20% of vitamin C, 10%-30% of procyanidine. The medicine provided by the invention has the advantages that the uric acid is reduced by multiple aspects of inhibiting the activity of xanthine oxidase, directly decomposing the uric acid, improving the kidney function, promoting the excretion of uric acid and protecting the blood vessels and the like, and the harm to the health of a human body is eliminated. Compared with the traditional medicine for reducing the uric acid, the medicine provided by the invention has the beneficial effects that except the function of reducing the uric acid, the effect of inhibiting the activity of the xanthine oxidase is also obviously improved, the blood fat and the kidney function are also obviously improved and no side effect is caused.

The invention discloses application of high mangiferin and aglycon thereof in preparation of a medicament for preventing and treating hyperuricemia and in particular relates to application of high mangiferin and aglycon thereof in preparation of a medicament for preventing and treating hyperuricemia as well as gout and lithangiuria brought by the hyperuricemia, and a medicine application way. The high mangiferin and aglycon thereof provided by the invention can be used for obviously reducing the concentration of serum uric acid in an animal for experiment and have the serum uric acid inhibition effect similar to that of a xanthine oxidase inhibition medicament allopurinol; and simultaneously, the high mangiferin and aglycon thereof provided by the invention can be used for obviously improving the concentration of uric acid in urine and have the uric acid excretion promoting function similar to that of a uric acid excretion promoting medicament probenecid. The high mangiferin and aglycon thereof provided by the invention are efficient, low in toxicity and high in safety, thus the high mangiferin and aglycon thereof are wide in application prospect.

The invention discloses a plant composition for treating hyperuricemia and gout and plant composition solid granules. The plant composition is prepared from celery seed extract, corn silk powder, pumpkin powder, lotus leaf powder, mulberry powder, ginseng powder grape powder by mixing. The plant composition solid granules are mainly prepared from the plant composition. According to the plant composition for treating the hyperuricemia and the gout and the plant composition solid granules, the celery seed extract, the corn silk powder, the pumpkin powder, the lotus leaf powder, the mulberry powder, the ginseng powder and the grape powder are compounded for use to improve the nutritional compositions, and the celery seed extract can significantly reduce the serum uric acid level and the urineuric acid level of the hyperuricemia; the corn silk powder and the lotus leaf powder can accelerate urinary excretion and help uric acid excretion; and the pumpkin powder, the mulberry powder, the ginseng powder and the grape powder have the functions of nourishing the liver and kidney, enhancing immunity and protecting the liver and kidney. The action mechanism of each component is different, multi-component mixing effectively exerts the synergistic effect between the components, the action time is prolonged, the curative effect is enhanced, and the components are homologous to medicine andfood, are safe and have no side effects.

The invention belongs to the field of medicines or health products, and particularly relates to a novel use of sesquiterpenoid in reducing uric acid. The sesquiterpenoid has a structure represented byformula (I): wherein X, R1-R11 are as defined in the description of the invention. Through an animal model of hyperuricemia, the sesquiterpenoid of the invention is found to promote uric acid excretion in vivo, has an obvious effect of reducing uric acid, and can be used as a potential medicine for reducing uric acid or treating gout.

The medicine composition for treating hyperuricemia consists of basic effective medicine components including astragalus root extract in 1-8 weight portions, cortex fraxini extract in 0.3-3 weight portions and tea extract in 0.1-2 weight portions, and pharmaceutically acceptable supplementary material. Of the basic effective medicine components, the astragalus root extract contains total astragaloside not less than 10 %, the cortex fraxini extract contains total cortex fraxini coumarin not less than 30 %,and the tea extract contains tea polyphenol not less than 50 %. The medicine composition may be prepared into common oral preparation or injection for controlling the acute attack of gouty arthritis, treating hyperuricemia and chronic uric acid type nephropathy, remitting arthralgia and promoting uric acid excretion.

The invention discloses an extract for artificially cultured phellinus igniarius fruiting bodies as well as a preparation method and application for the extract. The preparation method comprises the following steps of selecting Sangdu No. 1 as a phellinus igniarius strain, adopting a bagging cultivation method in imitating a wild condition under a forest, harvesting the fruiting bodies when the color of the fruiting bodies changes from yellow to brown or dark brown, and obtaining the phellinus igniarius fruiting bodies; and crushing the phellinus igniarius fruiting bodies into powder, soakingthe powder with an ethanol aqueous solution, performing reflux extraction, performing vacuum concentration on an extracting solution until an ethanol smell does not exist, and performing vacuum dryingto obtain the extract for the artificially cultured phellinus igniarius fruiting bodies. The extract disclosed by the invention is capable of improving and relieving kidney injury of a mouse with hyperuricemia and increasing uric acid excretion, is moderate in effect and less in side effects and can be used for preparing the drug and the health-care product for preventing and treating the hyperuricemia and gout.

The invention discloses a composition for preventing and treating hyperuricemia and gout and a preparation method and application thereof, and belongs to the field of traditional Chinese medicines. The composition for preventing and treating hyperuricemia and gout comprises the following raw materials: glabrous greenbrier rhizome, plantain herb, prepared rhubarb root and rhizome, radix achyranthisbidentatae and fragrant solomonseal rhizome. According to the invention, the glabrous greenbrier rhizome with effects of resolving dampness and purging turbidity is used as a monarch drug, the plantain herb with effects of dispelling dampness and promoting diuresis for assisting the glabrous greenbrier rhizome with the effects of resolving dampness and purging turbidity is used as a minister drug, the prepared rhubarb root and rhizome with effects of clearing hollow viscera and removing blood stasis is used as an assistant drug, and the radix achyranthis bidentatae with effects of removing blood stasis and guiding medicines downward and the fragrant solomonseal rhizome with effects of moistening stomach and coordinating the drug actions of a prescription are used as envoy drugs, so that the composition has the effects of resolving dampness and purging turbidity and clearing hollow viscera and removing blood stasis, which is beneficial to the discharge of uric acid from the urethra through the kidney and the excretion of uric acid from the intestinal tract, thus the composition has the pharmacological actions of remarkably reducing blood uric acid and accelerating uric acid discharge. The composition with "homology of medicine and food" can be prepared into various preparations such as capsules, granules and oral liquid, and is capable of being taken for a long time, free of toxic or side effect and wide in applicable population.

The invention belongs to the field of drugs or health care products, and particularly relates to new application of sesquiterpenoids to uric acid lowering. The sesquiterpenoids include the structure shown in a formula (I) (please see the specification for the formula (I)), wherein R1, R2, R3 and R4 are shown as definitions of a specification of the invention. Through a hyperuricemia animal model,it is found that the sesquiterpenoids promote uric acid excretion in vivo, has the significant uric acid lowering effect, and can serve as a potential drug for lowering uric acid or treating gout.

The present invention discloses a composition for promoting uric acid reduction. The composition comprises the following components in parts by weight: 10-25 parts of poria cocos, 10-25 parts of coixseeds, 10-20 parts of kudzuvine roots, 7-14 parts of psyllium seed husk powder, 8-16 parts of chia seed powder, 0.5-3 parts of skipjack elastin and 100 parts of auxiliary materials. The composition has the synergistic effect in a plurality of aspects such as reducing blood sugar, blood fat and cholesterol, promoting uric acid excretion, promoting the balance of ion metabolism of the body and promoting the balance of sputum metabolism, thereby jointly inhibiting the production of uric acid, increasing the excretion of uric acid and promoting the reduction of uric acid. The present invention also provides a preparation method of the composition. The preparation method subjects the poria cocos, the coix seeds and the kudzuvine roots to steaming, drying and pulverizing, and mixing the obtainedmixture with other components to obtain the composition suitable for administration.

The invention relates to traditional Chinese medicine composition for treating gout as well as a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the raw medicinal materials of ganoderma lucidum spore powder, poria cocos, plantago seeds, celery seeds and sunflower disks. The traditional Chinese medicine composition aims at the characteristics of gout; from tonifying liver and kidney, expelling wind, removing cold, removing dampness and dredging collaterals, varieties of medicine-food homology traditional Chinese medicine materials capable of reducing uric acid are chosen; according to the monarch, ministerial, adjuvant and conductant theory of traditional Chinese medicine, the effective pharmacological composition is provided; synergistic interaction is played, uric acid synthesis is inhibited, uric acid excretion is promoted, and a uric acid content level is effectively reduced; meanwhile, liver and kidney functions can be improved to a certain extent, an effect for promoting gout recovery is obvious, and the traditional Chinese medicine composition further has no toxic and side effects of the human body.

The invention relates to a food composition containing chitin for lowering and releasing uric acid and preventing gout, which comprises the following components in percentage by weight: 70-95% of chitin dietary fiber, 5-30% of yam powder, 0-3% of taurine and 0-3% of arginine. The food composition of the invention is provided with non-toxic side effects, is safe to eat, can prevent purine, fat and cholesterol from absorbing, restrain uric acid from forming and provide better effects of boosting kidney, keeping healthy, improving uric acid discharge and preventing gout.

The invention discloses a uric acid-lowering composition, which is composed of, by weight, 8-22 parts of mango, 5-14 parts of Yunnan Hovenia Thunb., 4-9 parts of cherry and 3-8 parts of Poria cocos. The composition has effects of neutralizing excessive acidic substances, regulating acid-base balance of body, promoting uric acid excretion, reducing uric acid level of serum and preventing renal lesions, metabolic diseases and cardiovascular disease caused by high uric acid content, and is suitable for those who suffer from gout, obesity, lithangiuria, ''three high''(hypertension, hyperglycemia and hyperlipemia) and the like. The preparation technology is simple and feasible, and is suitable for industrial production and market promotion and application.

The invention relates to application of fisetin in preparation of a medicine for preventing and treating uric acid nephropathy, and belongs to the field of medicine. The invention provides application of fisetin or salt thereof in preparation of the medicine for treating and / or preventing the uric acid nephropathy. Animal experiments prove that the fisetin can regulate protein expression of kidney urate transporters URAT1, OAT1, OAT3 and ABCG2, improve uric acid excretion rate and obviously reduce serum creatinine, blood urea nitrogen and blood uric acid levels, also has an effect of inhibiting renal interstitial fibrosis, can obviously reduce expression quantities of fibrosis-related proteins such as alpha-SMA, cologen I and fibronectin, has an exact prevention / treatment effect on the uric acid nephropathy and provides a new choice for clinical medication.

The invention provides a composition capable of lowering uric acid and a preparation method thereof, and relates to the field of health food. The main functional components of the composition includetheaflavin, resveratrol, dihydromyricetin, theanine and cordycepin in set proportion. The composition mainly plays a role to lower the uric acid and resist to gout by inhibiting the activity of xanthine oxidase, adjusting related anionic transporter mRNA and protein expression levels and promoting uric acid excretion; the composition can also relieve the matrix degradation of chondrocyte after IL-1[beta] stimulation and reduce the expression of inflammatory factors, so that the symptoms of osteoarthritis and bone and joint pain can be relieved; and the composition is significant in efficacy, obvious in uric acid lowering, good in safety and convenient in taking, and has good development and application prospects.

The invention discloses a method for screening uric acid-lowering small molecule compounds for promoting uric acid excretion based on a patch clamp technology. The method comprises the following stepsof: constructing recombinant plasmids for expressing a GLUT9 gene; instantaneously transfecting the recombinant plasmids to an HEK293T cell; after 18-24 hours, recording the change of a current whenthe GLUT9 cells are expressed to transport uric acid by utilizing a patch clamp technology; and verifying the reliability of the model through positive drugs, namely benzbromarone and probenecid, andnegative drugs, namely RDEA3170 and allopurinol. The method is simple, convenient and rapid to operate; the result is stable, reliable and good in reproducibility; compared with an existing method fordetecting isotope uptake by using xenopus oocytes, the method has the advantages that the consumed time is shorter, the cost is lower, and high-throughput screening of the GLUT9 inhibitor can be achieved.

The invention relates to medical new application and a preparation method of a nymphaea hybrid extract. Studies of the invention show that: the nymphaea hybrid aqueous extract can effectively reduce the blood serum blood uric acid level in a mice hyperuricemia model, one of the mechanisms of the the nymphaea hybrid aqueous extract is that: through inhibition of in-vivo xanthine oxidase activity, the formation of uric acid is inhibited and uric acid excretion is promoted. Hyperuricemia damages physiological functions of the kidney with increasing of urea nitrogen concentration being shown, and the nymphaea hybrid aqueous extract can reduce the blood uric acid, reduce stimulation of the uric acid on the kidney, and has a therapeutic effect on uric acid nephropathy. Therefore, the nymphaea hybrid aqueous extract can be used for preparing drugs for the treatment of gout, the hyperuricemia and the uric acid nephropathy.

The invention relates to a traditional Chinese medicine for treating gout. The traditional Chinese medicine comprises the following components in parts by weight: 12-18 parts of giant knotweed, 14-18 parts of Chinese lantern plant, 13-16 parts of vegetable sponge, 12-16 parts of golden cypress, 12-18 parts of rhizoma atractylodis, 10-16 parts of turtle shell, 18-22 parts of tokoro makino, 26-30 parts of cortex lycii radicis, 2-8 parts of liquorice, 2-5 parts of cicada slough and 2-5 parts of heracleum hemsleyanum michaux. The traditional Chinese medicine can clear heat, detoxicate, activate meridians, stop pain, induce diuresis, reduceg edema and promote in vivo uric acid excretion, thereby achieving the function of eliminating symptom and reducing blood uric acid.

The invention provides a traditional Chinese medicinal composition and a preparation method thereof. The traditional Chinese medicinal composition is prepared from the following raw materials in parts by weight: 9.5-12 parts of Cortex Phellodendri (Phellodendron chinense and / or Phellodendron amurense), 3-6 parts of Atractylodes lancea and / or Atractylodes chinensis rhizomes, and 4.5-6 parts of ginkgo leaf. The invention also provides a preparation method of the traditional Chinese medicinal composition. In the traditional Chinese medicinal composition, Cortex Phellodendri and ginkgo leaf both have xanthine oxidase inhibiting and anti-inflammatory effects, and Atractylodes lancea and / or Atractylodes chinensis rhizomes have good uric acid excretion promoting and anti-inflammatory effects. The combination of the above three raw materials can reduce uric acid content in human body by inhibiting secretion and promoting excretion, and can effectively relieve joint inflammation, resulting in good therapeutic effect on acute gouty arthritis.

The invention relates to the field of medicines and discloses a composition with a blood uric acid adjusting function. The composition consists of mangiferin and poria in a mass ratio of 1:0.1-100 and can be combined with conventional auxiliary materials to prepare a medicament and functional food with the blood uric acid adjusting function. The composition with the blood uric acid adjusting function can be used for remarkably improving the blood uric acid reduction effect, promoting the discharge of uric acid, compensating the shortcoming of the uric acid discharging function of the mangiferin and greatly reducing the influence on renal functions due to taking the single mangiferin reparation for a long time, and has the effect of assisting in improving the immunity. The medicament and functional food with the blood uric acid adjusting function prepared from the composition disclosed by the invention has the advantages of being simple in production process, stable in product quality, clear in functional factor, outstanding in health care effect, small in taking dosage, safe to use, free from side and toxic effects and the like, and is suitable for being taken by wide population with high uric acid.

The invention discloses a class of compounds for treating or preventing hyperuricemia or gout, which is a compound shown in general formula (I) or a pharmaceutically acceptable salt. These compounds and their pharmaceutically acceptable salts in the invention are useful for the promotion of uric acid excretion to treat or prevent hyperuricemia or gout.

The invention relates to the field of health care products, and particularly discloses a uric acid-reducing composition and a preparation method thereof, an oral medical agent and an application thereof, and the uric acid-reducing composition comprises the following raw materials: honeysuckle, chrysanthemum, lalang grass rhizome, reed rhizome, kudzuvine root, mulberry leaf, lotus leaf, lophatherumgracile, dandelion, corn stigma, liquorice, camellia nitidissima and red date. The uric acid-reducing composition provided by the invention can achieve the good uric acid reducing effect, can be usedfor reducing uric acid and preventing and treating gout through reasonable compatibility of various raw materials, is cheap, convenient and free of side effects, and can adjust purine metabolic disorder, promote uric acid excretion, reduce uric acid to a normal level and achieve the effect of treating gout by replacing medicines with tea without orally taking western medicines. The preparation method of the composition for reducing uric acid provided by the embodiment of the invention is simple, low in price and easy to implement, and solves the problem that most of the existing medicines forreducing uric acid are western medicines and have great side effects.

The medicine composition for treating hyperuricemia consists of basic effective medicine components including astragalus root extract in 1-8 weight portions, cortex fraxini extract in 0.3-3 weight portions and tea extract in 0.1-2 weight portions, and pharmaceutically acceptable supplementary material. Of the basic effective medicine components, the astragalus root extract contains total astragaloside not less than 10 %, the cortex fraxini extract contains total cortex fraxini coumarin not less than 30 %,and the tea extract contains tea polyphenol not less than 50 %. The medicine composition may be prepared into common oral preparation or injection for controlling the acute attack of gouty arthritis, treating hyperuricemia and chronic uric acid type nephropathy, remitting arthralgia and promoting uric acid excretion.

The invention relates to a polyphenol multi-element cyclodextrin inclusion compound for reducing uric acid and a preparation method thereof, and belongs to the technical field of medicine and health care products. The polyphenol multi-element cyclodextrin inclusion compound is prepared from the following raw materials in parts by weight: 2 parts of quercetin, 0.5 to 2 parts of dihydromyricetin, 0.5 to 2 parts of pueraria flavone, 0.5 to 2 parts of tea polyphenol, 0.2 to 1 part of chrysanthemum flavone, 5 to 15 parts of beta-cyclodextrin and 10 to 15 parts of mannitol. The invention aims to provide the polyphenol multi-element cyclodextrin inclusion compound capable of reducing uric acid and the preparation method thereof, which is capable of reducing uric acid can well inhibit xanthine oxidase and promote uric acid excretion, has a good anti-inflammatory effect, and has relatively strong effects of reducing uric acid and resisting gout.

The invention discloses fresh juice for treating gouty arthritis. The fresh juice consists of the following components in parts by weight: 30-35 parts of fresh juice of big radish, 25-30 parts of fresh juice of plantain herb, 20-25 parts of fresh juice of lysimachia christinae hance and 15-20 parts of honey, totaling 100 parts; the fresh juice is processed by the following steps: A, selecting and respectively cleaning fresh big radish, plantain herb and lysimachia christinae, draining off, extracting juice and filtering; B, mixing and uniformly stirring selected fresh honey with the filtered fresh juice of big radish, plantain herb and lysimachia christinae; and C, carrying out micro-membrane filtration, removing bacteria, removing precipitate, sterile filling and refrigerating at 1-8 DEG C. The fresh juice disclosed by the invention not only has the efficacies of inhibiting uricopoiesis, promoting uric acid excretion, and relieving local swelling and pain, but also is capable of avoiding such toxic and side effects as gastrointestinal reaction, influence on hepatic and renal functions, leucopenia and the like in modern medicine treatment as well as defects in traditional Chinese medicinal decoction treatment which is complex in decoction, bitter and difficult to swallow and not easy to accept by patients.

The invention relates to Garcinia mangostana L. fruit pericarp extract for treatment of gout and a preparation method thereof. The preparation method includes the following steps: using Garcinia mangostana L. fruit pericarp as a raw material, and carrying out extracting, concentrating and enriching on the Garcinia mangostana L. fruit pericarp, so at to obtain the Garcinia mangostana L. fruit pericarp extract for treatment of gout. Studies show that Garcinia mangostana L. fruit pericarp extract I and II have a strong uric acid-reducing effect, the uric acid level in serum of hyperuricemia miceinduced by oteracil potassium can be significantly reduced by intragastric administration of the Garcinia mangostana L. fruit pericarp extract I (20 mg / kg) or II (20 mg / kg); and fresh garcinia Mangostana L. fruit pericarp extract I and II and dried Garcinia Mangostana L. fruit pericarp extract I and II can significantly reduce the serum uric acid levels. In vitro studies show that the mechanism ofuric acid reducing action of the Garcinia mangostana L. fruit pericarp extract II is related to inhibition of uric acid production, while the mechanism of uric acid reducing action of the Garcinia mangostana L. fruit pericarp extract I is related to promotion of uric acid excretion. Obvious toxic and side effects and animal deaths are not observed in mice after intragastric administration of theGarcinia mangostana L. fruit pericarp extract I (5.0 g / kg) and II (5.0 g / kg), respectively. Therefore, both the Garcinia mangostana L. fruit pericarp extract I and II can be used to prepare oral drugsand health products to resist gout and hyperuricemia and to treat diseases related to hyperuricemia.