The invention discloses a preparation method of a
levocarnitine compound, and the preparation method is applied to the technical field of pharmaceutical
chemical synthesis. The preparation method comprises the following steps that (1), 4-chloroacetoacetic acid
ethyl ester serves as the initial
raw material, under the condition that a
solvent exists, an asymmetric catalyst
phosphine ligand
ruthenium complex is applied for hydrogenation reduction, and (R)-4-
chlorine-3-hydroxybutyrate
ethyl ester is obtained by vacuum concentration and high
vacuum distillation; (2), a
trimethylamine squeous solution and the (R)-4-
chlorine-3-hydroxybutyrate
ethyl ester are added dropwise and slowly in the
solvent comprising inorganic base, the dropping speed is controlled, low temperature reaction is carried out, then indoor temperature reaction is carried out, the pH of the mixture is adjusted to be 6 through concentrated
hydrochloric acid after reaction is finished, and the
levocarnitine compound is obtained by resin column purification. According to the method, the asymmetric catalytic reaction is applied, the two-step reaction that an optical active intermediate with high optical purity and high yield can be obtained and the optical active intermediate is converted to be the
levocarnitine compound is the one-pot reaction, the water serves as the reaction
solvent, the inorganic base is used for
catalysis, the unique process of indoor temperature reaction is adopted, the product quality is good, the purity is high, the yield can reach up to 80%, the reaction steps of the preparation method are short, operation is easy,
pollution to environment is small, and green resources are protected.