237 results about "Acetyl chloride" patented technology

The invention belongs to the technical field of specific fluorescent probe detection, and particularly relates to a near-infrared fluorescent probe for detecting hydrazine hydrate as well as a preparation method and application of the near-infrared fluorescent probe. The structural formula of the near-infrared fluorescent probe is # imgabs0. The invention provides a preparation method for synthesizing the probe by taking xanthene dye and acetyl chloride as raw materials. By researching the fluorescence spectrum of the fluorescent probe, the selectivity of the probe on N2H4 is evaluated, the fluorescence intensity of the probe is determined to be obviously enhanced only in the presence of N2H4, and the fluorescence intensity is positively correlated with the concentration of N2H4; meanwhile, the probe has the characteristics of quick response and near-infrared emission; the fluorescent probe disclosed by the invention has relatively small cytotoxicity and can be applied to detection of HepG2 cell exogenous hydrazine hydrate.

The invention discloses a synthesis process of vitamin C ethyl ether, and belongs to the technical field of vitamin C derivative synthesis. The process comprises the following steps: taking L-ascorbic acid as a raw material, adding acetone, anhydrous cupric sulfate and acetyl chloride, and reacting for 1-2 hours at 38-40 DEG C under the protection of nitrogen to obtain a vitamin C protector; adding alkali, water, an alkylating reagent and absolute ethyl alcohol into the reaction product, reacting for 3 hours at 75-78 DEG C under the protection of nitrogen, and performing reduced pressure distillation to obtain a vitamin C protector etherate; and finally, hydrolyzing by using cationic resin, removing a protecting group, and recrystallizing by using ethyl acetate to obtain the vitamin C ethyl ether. Through the synergistic catalysis of anhydrous cupric sulfate and acetyl chloride, the reaction time is remarkably shortened, and the product purity and yield are improved. Through detection, the product purity is more than 99.5%, the total yield can reach more than 80%, and an efficient and economical method is provided for industrial production of vitamin C ethyl ether.

The invention belongs to the technical field of packaging materials, and particularly relates to a composite film paper material and a preparation method thereof. The composite film paper material comprises a composite film layer and a paper layer, the composite film layer is prepared from the following components in parts by weight: 60 to 70 parts of polylactic acid, 20 to 30 parts of polybutylene terephthalate adipate, 5 to 8 parts of polyether polyol, 5 to 8 parts of esterified hydrophobic fumed silica and 3 to 5 parts of quinoline; the preparation process of the esterified hydrophobic fumed silica comprises the following steps: stirring fumed silica and acetyl chloride, and drying to obtain the esterified hydrophobic fumed silica. The esterified hydrophobic fumed silica, the polylactic acid, the quinoline and the polyether polyol are mixed according to a scientific proportion, and the barrier property of the composite film paper material is remarkably improved by utilizing the hydrophobicity of the esterified hydrophobic fumed silica and a compact structure formed among the components, and meanwhile, the mechanical property of the composite film paper material is not influenced.

The invention discloses piperonyl butoxide and a preparation method thereof. The preparation method comprises the following steps: carrying out mixing reaction on dihydrosassafras oil, acetyl chloride and trioxymethylene in the presence of concentrated hydrochloric acid; after the reaction is finished, chloromethyl material reaction liquid is obtained; mixing and reacting the chloromethyl material reaction liquid with sodium hydroxide and diethylene glycol monobutyl ether to obtain a product containing piperonyl butoxide. According to the preparation method of piperonyl butoxide, the dihydrosassafras oil, acetyl chloride and trioxymethylene are subjected to chloromethylation reaction in the presence of a small amount of concentrated hydrochloric acid, so that the use of a large amount of concentrated hydrochloric acid in the traditional process is avoided, and the problem of waste acid generated in the chloromethylation reaction process is solved; and meanwhile, the content of piperonyl butoxide in the product can be increased, and the content of piperonyl butoxide is ensured to be greater than 98%.

The invention provides a cyclodextrin ionic liquid demulsifier and a preparation method thereof. The demulsifier takes cyclodextrin as a core, and the surface of the demulsifier is grafted with tertiary amine with long-chain alkane through chloroacetyl chloride. The preparation method comprises the following steps: S1, modifying cyclodextrin with chloroacetyl chloride to obtain chloroacetyl chloride modified cyclodextrin; and S2, grafting chloroacetyl chloride modified cyclodextrin by using tertiary amine with long-chain alkane to obtain the cyclodextrin ionic liquid demulsifying agent. The demulsifier has the characteristics of low amount, high efficiency, easiness in degradation, salt resistance, acid resistance, alkali resistance and the like, and has a good demulsification effect on oil-containing wastewater and high oil removal rate.

The invention belongs to the technical field of chemical pharmacy, and particularly relates to a preparation method and application of an impurity of a beta2 adrenal receptor stimulant and M receptor antagonist bifunctional active compound. According to the impurity preparation method of the beta2 adrenal receptor stimulant and M receptor antagonist bifunctional active compound, acetylation of amino is successfully realized by using acetylation reagents such as acetyl chloride and alkali accelerators such as N, N-diisopropylethylamine, then debenzylation is performed through hydrogenation reaction, and the compound shown in the formula I is successfully prepared. Then, through liquid chromatography purification, a high-purity compound as shown in the formula I is obtained, and the raw material medicine as shown in JKN2304 can meet the requirements of reference substances in the research and development process; the technical problem that in the prior art, an impurity synthesis process of a beta 2 adrenal gland receptor agonist and M receptor antagonist bifunctional active compound is lacked is solved.

Belongs to the technical field of pine wood nematode disease prevention and control, and particularly relates to a preparation method and application of a pyrazole-chitosan oligosaccharide derivative. Chloroacetyl chloride serves as an acylating agent, chitosan oligosaccharide is acetylated, and chloroacetyl chitosan oligosaccharide is generated; then, a pyrazole molecule with nematicidal activity is connected to the Cl site of the chloracetyl chitosan oligosaccharide through ammonolysis reaction, and the novel pyrazole-chitosan oligosaccharide derivative is obtained. The derivative has relatively high contact activity on pine wood nematodes, and LC50 of 24 hours and LC50 of 48 hours are 4.814 mM and 4.061 mM respectively; the chitosan oligosaccharide can remarkably inhibit multiple physiological indexes such as movement, feeding and service life of the pine wood nematodes, and is good in stability, low in molecular weight of the chitosan oligosaccharide, good in water solubility, green and environment-friendly, and the plant toxicity is remarkably reduced. The derivative has a good application prospect in the aspect of controlling the pine wood nematode disease and can be applied to prevention and control of the pine wood nematode disease.

The invention belongs to the technical field of preparation processes of chemical products, and particularly relates to a method for preparing chloroacetyl chloride through a reaction tower and a rectification tower and an integrated tower preparation device. The invention relates to a method for preparing chloroacetyl chloride by a reaction tower and a rectification tower, which comprises the following steps of: metering liquid chloroacetic acid, preheating the liquid chloroacetic acid by a preheater, metering raw material thionyl chloride, gasifying the raw material thionyl chloride in a gasifier, feeding the gasified raw material thionyl chloride into the bottom of a reaction tower, and reacting the raw material thionyl chloride with the chloroacetic acid from the upper part of the reaction tower in the reaction tower, the tower bottom of the reaction tower is heated by a reboiler; and 2, cooling reaction steam from the reaction tower through a tower top condenser, enabling reflux liquid to enter the tower top of the reaction tower for total reflux, carrying out mass transfer and heat transfer on the steam in the reaction tower, extracting from a side line pipeline, and cooling through a side extraction condenser to obtain the finished product chloroacetyl chloride. According to the method for preparing chloroacetyl chloride through the reaction tower and the rectification tower, energy is saved, consumption is reduced, the product quality is stable, and the purity is high; the invention further provides an integrated tower preparation device which is low in investment and high in efficiency.

The invention relates to the technical field of pretilachlor synthesis, in particular to a process for synthesizing pretilachlor through continuous acylation, which at least comprises the following steps: conveying 2, 6-diethyl anilino propyl ether and chloroacetyl chloride into a microchannel reactor for reaction to generate a pretilachlor mixture; the pretilachlor product is prepared by sequentially carrying out flash evaporation treatment, high-temperature treatment, alkali washing treatment and dehydration on the pretilachlor mixture, and compared with a traditional production process, the process flow is simple, and efficient and environment-friendly continuous production of pretilachlor is realized.

The invention discloses a preparation method of antibacterial modified polylactic acid for a packaging material, and belongs to the technical field of functional modification of polylactic acid.The preparation method comprises the steps that an antibacterial barrier type polylactic acid composite material is prepared through ring opening polymerization of an initiator, grafting of antibacterial molecules and blending of montmorillonite, a chlorine-terminated initiator is generated from ethanolamine and chloroacetyl chloride, and the antibacterial modified polylactic acid is prepared; the preparation method comprises the following steps: initiating ring-opening polymerization of L-lactide to form polylactic acid with terminal group activity, covalently grafting terminal group chlorine with an antibacterial modifier through nucleophilic substitution, endowing the polylactic acid with antibacterial property, coupling modified montmorillonite with silane through organic intercalation, and then carrying out melt blending with the modified polylactic acid with antibacterial property to form a layered barrier structure and enhance interface bonding. Therefore, the film has the advantages of high barrier property, high tensile strength, excellent antibacterial activity and good degradability.

The utility model provides an acetoxyacetyl chloride synthesizer which comprises a first synthesis kettle and a second synthesis kettle, the top of the first synthesis kettle and the top of the second synthesis kettle are both communicated with a first metering tank and a second metering tank through pipelines, and the first metering tank and the second metering tank are both provided with feeding pumps. The bottom of the first synthesis kettle and the bottom of the second synthesis kettle are communicated with a rectifying kettle through pipelines, a rectifying assembly is arranged at the top of the rectifying kettle, and a discharge port is formed in the bottom of the rectifying kettle; the whole device is simple in structure, the two synthesis kettles can be alternately used, so that the production efficiency is effectively improved, acidic mixed waste gases such as sulfur dioxide and hydrogen chloride are not generated, the utilization rate of raw materials theoretically reaches 100%, the device completely conforms to an environment-friendly and pollution-free green process, the reaction process is mild, and the production cost is low. The reaction speed can be controlled by controlling the temperature and the catalyst input amount, the production operation is safe, the production cost is low, and the benefit is high.

The invention discloses a novel high-efficiency soil conditioner and its preparation method and application, and belongs to the technical field of soil improvement. The invention is used to solve the problem that the ability of soil conditioners used in saline-alkali land to reduce salt needs to be improved and the efficiency is low in the prior art; wherein the novel high-efficiency soil conditioner is obtained by uniformly mixing octasulfide, humic acid, montmorillonite, potassium sulfate, magnesium sugar alcohol and additives; wherein the preparation method of the additive comprises adding modified polyacrylic acid and modified apatite to acetone, reacting to obtain quaternary ammonium salt grafted apatite; adding bamboo powder to ionic liquid BMIMCl, adding chloroacetyl chloride, stirring, mixing, and obtaining intermediate I; in a nitrogen atmosphere, mixing intermediate I, quaternary ammonium salt grafted apatite and a catalyst, and reacting to obtain the additive under room temperature. The soil conditioner prepared by the present invention can improve soil quality, improve soil structure, enhance soil nutrient retention capacity and promote plant growth, and increase economic value.

The invention discloses a method and system for continuously synthesizing 2, 4-dichloroacetophenone, and the method for continuously synthesizing 2, 4-dichloroacetophenone comprises the following steps: S1, mixing m-dichlorobenzene and a catalyst to form a turbid liquid, and continuously inputting the turbid liquid into a tubular reactor; s2, enabling gas-phase acetyl chloride to pass through a micro-interface generator to form micron-sized microbubbles, continuously inputting the micron-sized microbubbles into a tubular reactor, and carrying out mixed reaction on the micron-sized microbubbles and the turbid liquid to obtain a mixed reaction liquid; and S3, continuously inputting the mixed reaction liquid and water into a hydrolysis reactor, and carrying out hydrolysis and separation to obtain 2, 4-dichloroacetophenone. According to the invention, the traditional kettle type stirring reaction is changed into micro-interface reaction, and the mass transfer area and the total mass transfer rate among multiple phases can be multiplied, so that the reaction rate is greatly improved, the side reaction is effectively controlled, and meanwhile, the product yield, the reaction safety and the like are improved.

The invention discloses a method for preparing methyltriacetoxysilane from acetic anhydride-containing acetyl chloride distillation tailings, and relates to the technical field of organic silicon synthesis, the method comprises the following steps: adding methyl trichlorosilane and acetic anhydride-containing acetyl chloride distillation tailings into a reaction kettle, stirring and heating; after a total reflux condition is reached, maintaining total reflux for a period of time, and then starting to collect acetyl chloride; continuously heating until the collection of acetyl chloride is completed, stopping heating, and when the temperature of the kettle is reduced to room temperature, heating again and starting vacuum negative pressure; when the kettle temperature reaches a set value, stopping heating, stopping stirring, and closing vacuum negative pressure; and after the kettle temperature is reduced to room temperature, adding pretreated activated carbon, carrying out decoloration reaction, and carrying out suction filtration after the reaction is completed, thereby obtaining the product. According to the method, a large amount of acetic anhydride in the acetyl chloride distillation tailings is used as a raw material and directly reacts with methyl trichlorosilane to prepare methyltriacetoxysilane, and the quality of the obtained product is remarkably higher than that of a product prepared by a normal process.

The invention provides photovoltaic support wood, a preparation method thereof, a skid-mounted photovoltaic support comprising the photovoltaic support wood and a photovoltaic tool. The preparation method comprises the following steps that wood raw materials are subjected to first soaking in a hydrogen peroxide aqueous solution, and wood A is obtained; the wood A is soaked in a titanium tetrachloride aqueous solution for the second time, boric acid powder is added into the system, and wood B is obtained; the wood B is subjected to third soaking in a mixed solution D containing glacial acetic acid and acetyl chloride, and wood C is obtained; and the wood C is subjected to hot pressing treatment, and the photovoltaic support wood is obtained. A specially treated wood material is used as a frame of the photovoltaic support, so that high-strength design and quick disassembly and transportation of the skid-mounted photovoltaic support can be realized, and the service life of the photovoltaic support in different environments can be prolonged.

The application discloses a method for preparing 3-methoxy-3-methyl-1-butyl acetate, and belongs to the technical field of organic compound synthesis. The method comprises the following steps: taking 3-methoxy-3-methyl-1-butanol as raw material, and respectively adopting acetic acid, acetic anhydride and acetyl chloride as acetylation reagents, and adding a catalyst or an acid-binding agent to perform acetylation reaction, so as to obtain 3-methoxy-3-methyl-1-butyl acetate. The application provides a synthesis method for 3-methoxy-3-methyl-1-butyl acetate, takes 3-methoxy-3-methyl-1-butanol as raw material, respectively adopts acetic acid, acetic anhydride and acetyl chloride as acetylation reagents, adds a catalyst or an acid-binding agent to perform acetylation reaction, and obtains 3-methoxy-3-methyl-1-butyl acetate. In view of the defect that there is no acetylation synthesis process suitable for the target product in the prior art, the related technical blank is filled.

The utility model provides a chloracetyl chloride mixing device, which belongs to the technical field of chloracetyl chloride preparation, and comprises a mixing tank and a limiting component, the top of the mixing tank is provided with a cover plate, the middle of the cover plate is provided with a rotating column, the middle of the rotating column is provided with cross-shaped grooves which are arranged in an up-down array mode, and the middle of each cross-shaped groove is provided with a support. A limiting assembly is arranged in the middle of the support and comprises springs and clamping plates, the springs are arranged in the middles of the two sides of the support, the same clamping plate is arranged at one ends of the springs located on the same side, the size of the clamping plate is equal to that of one end of the cross-shaped groove, and stirring assemblies are arranged on the two sides of the support; according to the utility model, the maintenance convenience of the stirring part can be improved.

The invention provides a synthesis method of L-acetoxypropionyl chloride, and belongs to the field of medical intermediates and fine chemical engineering. The preparation method comprises the following steps: mixing L-lactic acid and acetyl chloride for first reaction; then adding trichlorotoluene and a catalyst to carry out a second reaction; and then rectifying and separating to obtain the product L-acetoxypropionyl chloride. According to the method, two raw materials react to generate two products, no sulfur dioxide or acidic mixed waste gas is generated, the utilization rate of the raw materials reaches 100% theoretically, and the method completely conforms to an environment-friendly and pollution-free green process. The safety of the used trichlorotoluene is far higher than that of thionyl chloride and phosgene, the reaction is mild, the reaction speed can be controlled by controlling the temperature and the input amount of the catalyst, the production operation is relatively safe, and the purity of the prepared L-acetoxypropionyl chloride product is greater than 99%, and the yield is greater than 90%.

The invention discloses a qualitative and quantitative analysis method for polyolefin oxidation products, and belongs to the technical field of polyolefin oxidation product analysis. The method comprises the following steps: collecting a headspace gas phase product of a reaction kettle through an air bag and injecting an internal standard substance; filtering or centrifuging to remove the catalyst in the kettle bottom to obtain reaction liquid; removing the solvent by adopting a rotary evaporation technology to obtain a concentrated polyolefin oxidation product; and carrying out methyl ester derivatization treatment on the concentrated product by using a methanol solution of acetyl chloride as an esterification reagent, fixing the volume of the derivatization product to a certain volume, and adding an internal standard substance to obtain a liquid sample to be detected. Carrying out qualitative analysis on the liquid product by using GC-MS to reveal the molecular structure of the liquid product; gC-FID is used for quantitative analysis, and the product yield is calculated through an effective carbon number method. And carrying out quantitative analysis on a gas phase product through GC-TCD. The invention provides an efficient and accurate technical means for qualitative and quantitative analysis of polyolefin oxidation products, and further promotes the progress of a plastic recovery technology.

The invention discloses a preparation process of 2-chloro-4-(methylsulfonyl)-3-methyl benzoic acid, and relates to the technical field of preparation of inorganic compounds. The invention relates to a preparation process of 2-chloro-4-(methylsulfonyl)-3-methyl benzoic acid, which comprises the following steps: reacting 3-chloro-2-methylaniline with hydrochloric acid and sodium methyl mercaptide to form an intermediate C1, reacting with acetyl chloride, catalyzing with anhydrous aluminum trichloride to form an intermediate C2, reacting with hydrogen peroxide and sodium hypochlorite to form an intermediate C4, and reacting with sodium chloride to form the 2-chloro-4-(methylsulfonyl)-3-methyl benzoic acid. The 2-chloro-4-(methylsulfonyl)-3-methyl benzoic acid is obtained after the reaction is completed.

The invention relates to the technical field of refining of high-purity boric acid, and particularly discloses a method for removing divalent metal ions in high-purity boric acid, which comprises the following steps: dissolving the high-purity boric acid in water, filtering, adsorbing by adsorbent resin, filtering to obtain a refined boric acid solution, cooling, crystallizing, evaporating, crystallizing, carrying out suction filtration, and crushing to obtain the refined boric acid. The preparation method of the adsorption resin comprises the following steps: (1) blending polystyrene master batches with acetyl chloride, dispersing, and adding Lewis acid for reaction to obtain acetylated polystyrene particles; and (2) dispersing acetylated polystyrene particles, mixing with p-aminobenzene arsenic acid to react, filtering, and washing with alcohol to obtain the adsorption resin. After the high-purity boric acid is treated by the adsorbent resin prepared by the invention, the purity of the high-purity boric acid can reach 99.99%, and the effect of removing divalent metal ions in the high-purity boric acid can be realized.

This invention relates to the field of dichloroacetic acid preparation technology, specifically a method for preparing high-purity dichloroacetic acid. The method uses anhydrous dichloroacetic acid alkyl ester or anhydrous dichloroacetyl chloride as a single raw material. The method includes: adding deionized water to a corrosion-resistant reactor, starting stirring and cooling to 10-30°C, adding the single raw material and an acidic catalyst, reacting at 40-80°C for 1-8 hours, and then refining through multi-stage separation to obtain high-purity dichloroacetic acid. The anhydrous dichloroacetic acid alkyl ester is selected from methyl dichloroacetate, ethyl dichloroacetate, propyl dichloroacetate, or isopropyl dichloroacetate. The acidic catalyst is a ZrO₂-TiO₂ supported acid solid catalyst or a complex liquid organic acid catalyst.

The invention discloses a preparation method of N-methyl o-fluoroaniline, which is characterized in that o-fluoroaniline is used as a starting raw material, and a target product is efficiently synthesized through three steps of reaction: step 1, in the presence of a solvent and alkali, o-fluoroaniline and acetyl chloride are acetylated at low temperature to generate 2-fluoro-acetanilide, and the product is directly used for the next step after being roughly purified; 2, under the action of a solvent and alkali, carrying out controllable methylation on the 2-fluorine-acetanilide and dimethyl carbonate to obtain 2-fluorine-N-methylacetanilide; and 3, removing acetyl protection through acidic hydrolysis, and adding sodium thiosulfate to prevent oxidation to finally obtain a high-purity product. According to the method, excessive methylation is avoided through an acetyl protection strategy, the process does not need high-risk operations such as ultralow temperature and high pressure, the operation is simple and convenient, the energy consumption is low, and the product purity is gt; the total yield reaches 79.86%, and the method is green, safe and suitable for industrial production.

The invention relates to the technical field of synthesis of chlorine-containing pyridine intermediates, and discloses a method for synthesizing 2, 3, 4, 5-tetrachloropyridine by using 2, 5-dichloropyridine, which comprises the following steps: step 1, preparation of 2, 5-dichloropyridine nitrogen oxide: taking 2, 5-dichloropyridine as a raw material, reacting in the presence of a catalyst and acetic acid, and then filtering to remove the catalyst to obtain 2, 5-dichloropyridine nitrogen oxide; adding an acetic acid solution of 2, 5-dichloropyridine nitrogen oxide; step 2, nitration reaction: adding sulfuric acid and nitric acid, and reacting to obtain 2, 5-dichloro-4-nitropyridine nitrogen oxide; step 3, nitrogen and oxygen removal reaction: adding acetyl chloride to replace 4-position nitro to obtain 2, 4, 5-trichloropyridine nitrogen oxide, and then adding phosphorus trichloride to remove nitrogen and oxygen to obtain 2, 4, 5-trichloropyridine; and 4, chlorination and refining: adding Lewis acid into the 2, 4, 5-trichloropyridine, reacting to obtain a 2, 3, 4, 5-tetrachloropyridine crude product, and refining the crude product to obtain the finished product 2, 3, 4, 5-tetrachloropyridine. The invention solves the problems of more byproducts and unsatisfactory product purity and yield in the prior art.

The invention discloses a high-boiling-point styryl liquid cross-linking agent, a preparation method thereof and organic medium slurry of a high-frequency and high-speed copper-clad plate. The preparation method of the high-boiling-point styryl liquid cross-linking agent comprises the following steps: carrying out Friedel-Crafts reaction on toluene and dichloroethane to obtain 1, 2-bis (methyl benzene) ethane; the preparation method comprises the following steps: carrying out Friedel-Crafts reaction on dimethyl phenylethane and acetyl chloride to obtain 1, 2-bis (methyl acetyl benzene) ethane; the preparation method comprises the following steps: carrying out reduction reaction on 1, 2-bis (methyl acetyl benzene) ethane and sodium borohydride to obtain 1, 2-bis (methyl alpha hydroxyethyl benzene) ethane; and carrying out dehydration to obtain the 1, 2-bis (methyl vinyl benzene) ethane cross-linking agent. The 1, 2-bis (methyl vinyl benzene) ethane is in a liquid state at normal temperature, has high solubility for SEBS and other film-forming resins, can reduce the solvent amount for copper-clad plate manufacturing, is a high-boiling-point cross-linking agent, and has wide application prospects.

A beta-acetylnaphthalene production device belongs to the technical field of chemical equipment and comprises a dissolving kettle, a tubular reactor, a hydrolysis liquid separation kettle and an external evaporation crystallization kettle, a dissolving kettle solid feed inlet and a dissolving kettle liquid inlet are formed in the top of the dissolving kettle, a dissolving kettle liquid outlet is formed in the bottom of the dissolving kettle, and a first constant-temperature heat exchanger is arranged on the outer wall of the dissolving kettle; a solid feeding port of the dissolving kettle is connected with a solid feeding machine through a pipeline and connected with a valve in series, a liquid inlet of the dissolving kettle is connected with a solvent storage tank through a pipeline and connected with a valve, an electronic flowmeter and a transmission pump in series, and a liquid outlet of the dissolving kettle is connected with a tubular reactor and an acetyl chloride storage tank through a first tee joint. According to the utility model, beta-acetylnaphthalene can be continuously produced in a continuous feeding and intermittent discharging manner, so that the production efficiency is improved, and the production cost is reduced; meanwhile, through the design, multiple treatment procedures are simplified in one device for treatment, the device utilization rate is increased while the device is simplified, the occupied space of production equipment is saved, and industrial popularization is facilitated.

This invention provides a method for preparing and purifying methyl isoglycyrrhizate. The preparation method includes reacting isoglycyrrhizic acid (of formula I) or its salt in a mixed solvent of methanol and methyl acetate in the presence of acetyl chloride. The purification method involves adding crude methyl isoglycyrrhizate to a mixed solvent of organic solvent and water after the reaction, heating and stirring to dissolve; then adding water dropwise, cooling to allow crystallization, and filtering to obtain a solid. This invention, by adding a certain amount of methyl acetate during the reaction, can ensure the conversion rate, control the acidity of the reaction environment, reduce the degradation of methyl isoglycyrrhizate, and greatly improve the product yield and material utilization. The purification method for methyl isoglycyrrhizate provided by this invention can efficiently remove impurity A from the product, is simple to operate, uses little solvent, has a high yield, and is environmentally friendly.

The invention discloses a composite membrane material for sewage treatment and a preparation method thereof, and belongs to the technical field of sewage treatment, and the composite membrane material is prepared by loading three layers of different network polymers on the surface of a ceramic chip; the network-like polymer is prepared by performing esterification reaction on alpha-cyclodextrin, beta-cyclodextrin, gamma-cyclodextrin and 2, 2 '-[oxybis (ethylene glycol oxygen)] diacetyl chloride respectively; the composite membrane material for sewage treatment prepared by the invention has relatively strong adsorption performance, relatively high mechanical strength and stability, and has a good application prospect in the aspects of adsorption of refractory organic wastewater and treatment of heavy metals and ammonia nitrogen.

The invention relates to the field of medicinal chemistry, and provides a preparation method of metoclopramide intermediate methyl 2-methoxy-4-acetamidobenzoate, which comprises the following steps: mixing methyl 2-methoxy-4-acetamidobenzoate and acetic anhydride in a molar ratio of 1: (1.2-2.0) in the absence of a solvent, and reacting at the temperature of 50-80 DEG C; and after the reaction, adding methyl tert-butyl ether for crystallization, cooling and filtering to obtain a product. The method has the advantages that acetic anhydride is used as an acylation reagent; on one hand, compared with acetyl chloride, the reaction is more stable, the reaction controllability is better, and the product purity is high; on the other hand, acetic anhydride is liquid and can serve as a solvent, no extra solvent needs to be added, and cost is saved; meanwhile, no solvent is added, so that the post-treatment process is simplified, the operation is simple, and the yield is higher. The 2-methoxy-4-acetamidobenzoic acid methyl ester prepared on the basis of the method has the purity of 99.8% or above and the yield of 90% or above, and is suitable for industrial production.

The invention discloses a substituted quinoline compound and a preparation method and application thereof.The preparation method includes the steps that thionyl chloride and a specific intermediate react, DCM and other solvents are adopted, and pyridine, polyphosphoric acid, ethyl alcohol, acetyl chloride and other reagents are used in the reaction process. The structure of the obtained product is confirmed by a nuclear magnetic hydrogen spectrum, bactericidal activity tests are carried out on the obtained 29 target products, and the results show that the compound has a significant inhibition effect on a variety of plant pathogens at a concentration of 50 ppm, and especially shows excellent bactericidal activity in the aspects of pyricularia grisea, sclerotinia sclerotiorum and the like. In addition, the compounds have certain herbicidal activity.