103 results about "Oxazolidine" patented technology

The purpose of the present invention is to provide a prepreg which uses a resin composition that can be cured in a short period of time and is capable of suppressing resin flow during molding, and which has high workability. A prepreg characterized in that the prepreg contains an epoxy resin composition and reinforcing fibers, the epoxy resin composition containing component (A): a urea compound; component (B): a thermoplastic resin; component (C): an epoxy resin having an oxazolidinone structure; and component (D): a bisphenol epoxy resin that is solid at 25 DEG C, and satisfies the following conditions (1) and (2). Condition (1): The minimum viscosity of the epoxy resin composition measured by a rheometer under the condition of 2 DEG C / min is in the range of 3.0-6.0 Pa.s. Condition (2): the gelation time value of the epoxy resin composition, as measured under the condition of 145 DEG C by CURELASTOMETER (Registered Trademark), is in the range of 2.0-5.0 min.

This invention provides an inkjet composition set that exhibits excellent blocking resistance, adhesion, tackiness, and shrinkage properties. [Solution] A radiation-curable inkjet ink composition comprising a polyfunctional monomer with three or more functions and 5-methyl-3-vinyloxazolidine-2-one, wherein the content of 5-methyl-3-vinyloxazolidine-2-one is less than 50% by mass of the total amount of the ink composition, the content of monofunctional monomers is 60% by mass or more of the total amount of polymerizable compounds, and the content of polyfunctional monomers with three or more functions is more than 1% by mass of the total amount of the ink composition.

Disclosed are compositions and methods for the treatment of tuberculosis and other mycobacterial and gram-positive bacterial infections. These compositions comprise highly potent and selective oxazolidinones encapsulated with high efficiency to maximize the potential for low-toxicity drug delivery and are stable in the presence of plasma. The compositions are long-circulating and retain their encapsulated drug while in circulation following intravenous delivery to allow effective accumulation at the site of bacterial or mycobacterial infection. The high doses achievable and the long-circulating nature of the drug combined with the high stability of the formulation allow for a reduction in the frequency of administration compared to the once-daily or twice-daily administration of other drugs commonly used to treat these infections.

Disclosed is a preparation method, wherein a compound of formula (I) and a compound of formula (II) are used as starting materials to synthesize an oxazolidinone compound in the presence of a catalyst. Further disclosed is a use of a non-alkaline lithium salt and / or a quaternary ammonium salt as a catalyst in the synthesis of an oxazolidinone compound.

A method for producing thermoplastic polyoxazolidinone includes copolymerizing a diisocyanate compound (A) with a diepoxide compound (B) in a solvent (E) optionally in the presence of a specific quaternary ammonium, quaternary phosphorus, and / or quaternary antimony-based catalyst (C), compound (D), and compound (F), wherein compound (D) and compound (F) independently comprise at least one of a monofunctional isocyanate, a monofunctional epoxide, a cyclic carbonate, a monofunctional alcohol, and a monofunctional amine, and wherein the method is free of solvents (G) with a boiling point above 200°C (absolute) at 1 bar, preferably above 190°C, and more preferably above 180°C. The invention also relates to the resulting thermoplastic polyoxazolidinone.

The application discloses a preparation method of zolmitriptan, relates to the technical field of drug synthesis, and comprises the following steps: adding compound 1 and reagent 1 into solvent 1 to perform a first reaction to obtain compound 2; adding the compound 2, reagent 2 and reagent 3 into solvent 2 to perform a second reaction to obtain compound 3 and the like. Compared with the prior art, the application provides a novel synthetic route for preparing zolmitriptan, the route uses L-4-bromophenylalanine as a starting material, and new synthetic steps are adopted, such as using reagent 5, such as a t-butyl alcohol metal salt and sodium hydride, to construct the oxazolidinone structure in zolmitriptan and using a coupling reaction to construct the indole ring in zolmitriptan, so that the yield of the obtained target product is significantly improved, the use of high-toxicity and high-risk reagents in the existing synthetic route is effectively avoided, and a mild, efficient, green and environmentally-friendly synthetic route for preparing zolmitriptan is provided.

The invention provides an epoxy-terminated polyurethane flexibilizer and a preparation method and application thereof, and belongs to the technical field of epoxy composites.The epoxy-terminated polyurethane flexibilizer is prepared from polyol, isocyanate, a chain extender, a catalyst, metal salt and epoxy resin, and the chain extender comprises hydroxybenzoxazine. The epoxy-terminated polyurethane toughening agent provided by the invention contains carbamate groups, benzoxazine groups and five-membered oxazolidinone structures, the groups have strong polarity, and due to the introduction of the five-membered oxazolidinone and the benzoxazine groups, the toughening agent has excellent stability at a high temperature and in a salt mist old chemical process, so that the toughness of the toughening agent is improved, and the service life of the toughening agent is prolonged. The toughening agent is added into the epoxy resin structural adhesive, the adhesion of the epoxy resin structural adhesive to metal materials can be improved while the glass transition temperature is not reduced, and the toughening agent further contains a polyether chain segment which can improve the low-temperature impact resistance of the epoxy resin structural adhesive.

The invention discloses a preparation method of an azacyclo-bis (fluorosulfonyl) imide salt derivative, which comprises the following steps of: 1, mixing an azacyclo-compound, a methylation reagent, an ethylation reagent, bis (fluorosulfonyl) imide salt and inorganic alkali in a polar organic solvent, heating, and filtering after complete reaction to obtain crude filtrate containing the azacyclo-bis (fluorosulfonyl) imide salt; the nitrogen heterocyclic compound is selected from one of oxazolidine, 4-cyano piperidine, 4-fluoro piperidine, 4, 4-difluoro piperidine and 3-cyano piperidine; the bis (fluorosulfonyl) imide salt is selected from one of lithium bis (fluorosulfonyl) imide and potassium bis (fluorosulfonyl) imide; and 2, adding an inert organic solvent into the crude product filtrate for crystallization, and performing vacuum drying to obtain a finished product. The method has the advantages that the operation steps are few, the synthesis efficiency is greatly high, the process is greatly simplified, and the preparation cost is effectively reduced.

The present invention relates to a process for the enantioselective preparation of chiral 4-substituted 2-oxazolidinones of formula (la) or (lb) via asymmetric hydrogenation of the corresponding 4-substitued 2-oxazolones of formula (II) using a combination of palladium or nickel and a chiral bidentate P-ligand as catalyst. The oxazolidinones can then be converted to important chiral building blocks such as enantiopure chiral aminoalcohols and haloamines via decarboxylative ring opening reaction.

The invention discloses p-toluenesulfonic acid 8-tert-butyl diphenyl silyloxy-7-methyl octyl ester as well as a synthesis method and application thereof, and relates to the technical field of biopesticides. The preparation method comprises the following steps: taking 8-bromocaprylic acid as an initial raw material, and firstly reacting with t-BuOK and 18-crown ether-6; then reacting with pivaloyl chloride to generate acid anhydride, and then carrying out acylation reaction with 4-benzyl oxazolidine-2-ketone; then carrying out diastereoselective methylation; then, NaBH4 reduction is carried out; carrying out hydroxyl protection; then carrying out hydroboration oxidation reaction; and then carrying out TsCl sulfonylation, so as to synthesize the p-toluenesulfonic acid-8-tert-butyl diphenyl silyloxy 7-methyl octyl ester. The optical purity of the (S)-p-toluenesulfonic acid 8-tert-butyl diphenyl silyloxy-7-methyl octyl ester synthesized in the invention reaches 98%, and the optical purity of the (R)-p-toluenesulfonic acid 8-tert-butyl diphenyl silyloxy-7-methyl octyl ester synthesized in the invention also reaches 98%.

Provided are methods of forming a three-dimensional object that include irradiating a resin composition of the invention with actinic radiation or light, thereby forming a three-dimensional intermediate, and then further reacting the three-dimensional intermediate to form the three-dimensional object. In some embodiments, resin compositions of the invention include a polyisocyanate such as, e.g., a reactive blocked polyisocyanate; a polyfunctional epoxy compound; a photoinitiator; optionally, a catalyst; optionally, a polyol and / or a polyamine chain extender; optionally, a reactive diluent; optionally, a pigment or dye; and optionally, a filler. Related resin compositions are also provided herein. Further, provided are three-dimensional objects formed by a method of the invention, including, e.g., objects formed of a polymer having at least one oxazolidinone linkage.

The invention belongs to the technical field of caulking agents, and particularly relates to a polyurethane caulking agent and a preparation method thereof.The polyurethane caulking agent is prepared from, by mass, 35%-40% of siloxane modified dendritic polyether tetrahydric alcohol, 35%-40% of diphenylmethane diisocyanate, 5%-10% of plasticizer chlorinated paraffin, 3%-4% of 2-phenyl-5-trifluoromethyl-1, 3-oxazolidine latent curing agent, 1%-2% of foam stabilizer and 1%-2% of catalyst 2. 0.5-0.8% of 2, 2 '-dimorpholinyl diethyl ether, 5-8% of dimethyl ether and 5-8% of propane and butane. According to the polyurethane joint mixture, the 2-phenyl-5-trifluoromethyl-1, 3-oxazolidine latent curing agent is added, in the curing process, the latent curing agent reacts with water in advance of the diphenylmethane diisocyanate to form an amine substance, amido in the amine substance reacts with the diphenylmethane diisocyanate to generate a macromolecular polymer, curing of the polyurethane joint mixture is achieved, and the polyurethane joint mixture has the advantages that the curing effect is good; the curing time can be shortened, and the construction speed is increased.

The invention relates to fluorine-containing isoxazolidine-5-ketone as well as a synthesis method and anti-tumor application thereof. According to the synthesis method, gem-difluorocycloacrylimide and nitrone are taken as substrates, Ni (ClO4) 2.6 H2O is taken as a catalyst, (+ / -)-2, 2 '-(propane-2, 2-diyl) bis (4-phenyl-4, 5-dihydrooxazole) is taken as a ligand (L) in an organic solvent, cycloaddition isomerization reaction is carried out at about 30 DEG C, and the fluorine-containing isoxazolidine-5-ketone compound is obtained. And the fluorine-containing isoxazolidine-5-ketone is obtained through preparation. The method is mild in reaction condition, capable of being well compatible with various functional groups and high in yield, and the product further has certain biological activity and can inhibit proliferation of cancer cells. The invention discloses the realization of the cycloisomerization reaction of the gem-difluorocyclopropene and the nitrone for the first time, provides a new idea for the synthesis of the fluorine-containing isoxazolidine-5-ketone and the derivative thereof, and has a good application prospect in the fields of medicines and synthesis.

The invention relates to the technical field of coatings, in particular to dual-curing conformal coating as well as a preparation method and application thereof. The dual-curing three-proofing paint is composed of siloxane containing oxazolidinyl groups, a UV oligomer containing isocyanate groups, a diluting monomer, a water removal agent, a photoinitiator, a wetting agent, a catalyst and the like. Wherein the siloxane containing the oxazolidinyl group has two functional groups of long carbon chain oxazolidine and siloxane, the long carbon chain oxazolidine can realize rapid moisture curing of oligomer and does not generate volatile harmful substances, and meanwhile, hydrolysis residues of the long carbon chain oxazolidine can plasticize the conformal coating and reduce adhesion loss caused by shrinkage. On the other hand, siloxane groups can form a stronger physical or chemical action with a base material, so that the adhesive force to the base material is improved. In conclusion, the three-proofing paint has excellent low surface tension and high wettability, can effectively wet the polluted surface of the PCB and form interaction, has the characteristics of excellent adhesive force, salt mist resistance, high flexibility and the like, and has very high market application value.

The invention discloses a preparation method of zolmitriptan, and relates to the technical field of drug synthesis, and the preparation method comprises the following steps: adding a compound 1 and a reagent 1 into a solvent 1, and carrying out a first reaction to obtain a compound 2; and adding the compound 2, the reagent 2 and the reagent 3 into the solvent 2 for second reaction to obtain a compound 3, and the like. Compared with the prior art, the invention provides a brand-new synthesis route for preparing the zolmitriptan, and the route takes L-4-bromophenylalanine as an initial raw material; through brand-new synthesis steps of constructing an oxazolidinone structure in the zolmitriptan by adopting a reagent 5 such as tert-butyl alcohol metal salt and sodium hydride, constructing an indole ring in the zolmitriptan by adopting a coupling reaction and the like, the yield of the obtained target product is remarkably improved; meanwhile, the use of high-toxicity and high-risk reagents in an existing synthesis route is effectively avoided, and a mild, efficient and environment-friendly synthesis route is provided for preparation of zolmitriptan.

This invention discloses a modified graphene oxide, its preparation method, and an icebreaking anti-wear epoxy coating for marine vessels in ice-covered areas, as well as its application. The modified graphene oxide comprises a reaction product of an oxazolidinone compound and graphene oxide; the oxazolidinone compound is prepared from raw materials comprising: γ-(2,3-epoxypropoxy)propyltrimethoxysilane, diisocyanate, and a catalyst. The icebreaking anti-wear epoxy anti-corrosion coating for marine vessels of this invention exhibits excellent mechanical properties such as compression, bending, and tensile strength even at low temperatures, protecting the hull from the pressure and wear of ice layers, and demonstrates good adhesion and excellent anti-corrosion effect.

The invention belongs to the technical field of sealant prime coats, and particularly relates to a sealant prime coat for a silane modified sealant as well as a preparation method and application of the sealant prime coat. The sealant prime coat for the silane modified sealant comprises resin, a fluorine-containing organic solvent and a latent curing agent, the latent curing agent comprises a bisoxazolidine latent curing agent. The fluorine-containing organic solvent and the latent curing agent are adopted in the sealant prime coat, so that the bonding force of the silane modified sealant on the surface of a concrete base material can be improved, and the problems of poor bonding caused by a release agent, dust and the like, reduction of the bonding capacity after soaking in water and bonding damage caused by the problem of concrete alkali reversion in the long-term use process are solved; therefore, the long-term use performance of the sealant can be improved.

The present invention relates to a process for the preparation of an aqueous solution comprising N- Alkylhydroxylamine of formula (I) wherein the process comprises the following steps I) oxidizing a secondary amine of formula (II), II) adding an acid, III) distilling the received mixture of step II) in a distillation apparatus comprising a distillation column by removing a composition comprising water and byproducts at the top of the column until the purity of compound of formula (IIIb) in the residue is 95% or greater, IV) adding a base to the residue of step III), V) filtering the received slightly soluble salt off and VI) receiving the aqueous solution as filtrate. The present invention relates further to the aqueous solution obtainable by the inventive process and comprising water, N- alkylhydroylamine of formula (I) alkali cations, anions of sulfur acid, phosphoric acid, oxalic acid or mixtures thereof, the use of this inventive aqueous solution for the production of building blocks for active pharmaceutical and / or agriculturally compounds like 2-C1-C5-alkyl-4-amino-isoxazolidin-3-one.

The invention relates to the technical field of waterproof coatings, and discloses a modified organosilicon polymer and a preparation method thereof, a composition for a polyurea waterproof coating, and the polyurea waterproof coating and a preparation method thereof. The method for preparing the modified organosilicon polymer comprises the following steps: (1) in the presence of a solvent I, carrying out first mixing on a hydroxyl-terminated organosilicon compound and diisocyanate I to obtain an intermediate I; (2) carrying out second mixing on hydroxyl oxazolidine with a structure as shown in a formula (I) and the intermediate I to obtain an intermediate II; and (3) carrying out third mixing on a metal organic catalyst and the intermediate II to obtain the modified organosilicon polymer. The weather-resistant single-component polyurea waterproof coating provided by the invention has excellent weather resistance. Formula (I).

The present disclosure relates to compounds of formula (I) wherein R1 represents phenyl or monocyclic heteroaryl optionally substituted by one, two or three R3; r2 represents an aryl or heteroaryl group optionally substituted by one, two or three R6 groups; each R3 is independently selected from the group consisting of halogen, cyano, (C1-C4) alkyl, or (C1-C4) alkoxy; r4 and R5 are independently selected from halogen, (C1-C4) alkyl, (C1-C4) alkoxy, or R4 and R5 together form a (C1-C4) alkylene bridge; m and s are independently 0 or 1; p, q, r and t are independently 0 or 1; each R6 is independently selected from the group consisting of halogen, cyano,-NH2 group,-OH, (C1-C4) alkyl,-CF3,-C (O) NH2,-C (O) NH-(C1-C4) alkyl,-C (O) OH,-C (O) O-(C1-C4) alkyl,-SO2NH2, (C1-C4) alkoxy,-O-(C1-C4) alkylene-(C3-C6) cycloalkyl,-O-(C3-C6) cycloalkyl,-O-(C3-C6) heterocycloalkyl, (C3-C6) heterocycloalkyl, heteroaryl, and pendant oxygen groups; or a pharmaceutically acceptable salt, solvate or stereoisomer thereof. The present disclosure further relates to pharmaceutical compositions containing said novel compounds.

The application discloses a sulfide solid electrolyte, a preparation method thereof and a super capacitor. The sulfide solid electrolyte comprises an organic-inorganic composite film generated by a curing reaction of a raw material system. The raw material system comprises a first monomer, a second monomer, a lithium salt, a siloxane prepolymer and an initiator. The first monomer is N,N'-1,3-propanediyl bis(oxazolidine 2-ketone), and the second monomer is 4,4'-thiobisphenol diglycidyl ether. The application is based on the composite system sulfide solid electrolyte of N,N'-1,3-propanediyl bis(oxazolidine 2-ketone) and 4,4'-thiobisphenol diglycidyl ether, and the modification of the siloxane prepolymer and the optimized process parameters, so that the defects of the prior art can be effectively solved.

A method of fixating carbon dioxide (CO2) to form a substituted oxazolidinone is described. The method includes mixing a metal-organic framework (MOF), at least one epoxide, and at least one aromatic amine to form a mixture. The method further includes contacting the mixture with a gas stream containing CO2 to react the CO2 in the gas stream with the epoxide and the aromatic amine to form a substituted oxazolidinone. The MOF is a MIL-68(In)—X MOF. X is of formula (I):where at least one of R1 to R4 is an amine-containing group, and R1 to R4 are independently an amine-containing group or a hydrogen.

Oxazolidinone compounds that can be used as additives in coating compositions, coating compositions comprising such additives and their use in electrocoating, powder, packaging and liquid coating applications, as well as articles coated therewith, are disclosed.

We provide an active energy ray curing inkjet ink that excels in curability, adhesion, print quality, and ejection stability. [Solution] An active energy ray-curable inkjet ink comprising a polymerizable compound (excluding polymerizable compounds having siloxane bonds) (A) and a siloxane-based surface modifier, wherein the polymerizable compound (A) comprises 3 to 25% by mass of 5-methyl-3-vinyloxazolidine-2-one and a bifunctional or more functional acrylate compound, with the total content of both components being 45 to 85% by mass, and the siloxane-based surface modifier comprises 1 to 5% by mass of a siloxane-based surface modifier having an HLB value of 1.3 to 13.0, and further comprises a defined content of the polymerizable compound (A), monofunctional (meth)acrylate compound, and trifunctional or more functional (meth)acrylate compound.

The invention belongs to the field of pharmacology, and discloses a crystal form II of an oxazolidinone antibacterial candidate new drug OTB-658, and a preparation method, a composition and application of the crystal form II of the oxazolidinone antibacterial candidate new drug OTB-658. In particular to a crystal form II of N-(((3S, 3aS)-8-fluoro-1-oxo-7-thiomorpholinyl-3a, 4-dihydro-1H, 3H-benzo [b] oxazole [3, 4-d] [1, 4] oxazine-3-yl) methyl) acetamide, namely OTB-658, and a preparation method of the crystal form II of N-(((3S, 3aS)-8-fluoro-1-oxo-7-thiomorpholinyl-3a, 4-dihydro-1H, 3H-benzo [b] oxazole [3, 4-d] [1, 4] oxazine-3-yl) methyl) acetamide. The OTB-658 crystal form II is used as an active pharmaceutical ingredient to prepare drugs for treating and / or preventing bacteria, especially mycobacterium tuberculosis infectious diseases.

The application discloses a polyoxazolidinone prepared by heterogeneous catalytic bulk polymerization and a method, and belongs to the technical field of polymer material synthesis. The method comprises the following steps: uniformly mixing an antioxidant and a polyisocyanate, vacuum drying to obtain a mixed solution; uniformly mixing cardanol diglycidyl ether and bisphenol F diglycidyl ether, vacuum drying to form an epoxide composition; adding 1-butyl-3-methyl imidazole chloride and aluminum trioxide into mesoporous silica, and baking to obtain a supported heterogeneous catalyst; fully dispersing the composition and the catalyst, and then gradually adding the mixed solution under temperature rising, so that the conversion rate of an epoxy group reaches 68-72%; then, the mixed solution is gradually added under temperature rising, so that the conversion rate of the epoxy group is improved; finally, the mixed solution is gradually added under temperature rising, so that the reaction is completed; the filtered filtrate is degassed and granulated, and polyoxazolidinone particles are obtained, so that the purity, mechanical property and thermal stability of the polyoxazolidinone are improved.

A radiation curable ink jet ink composition includes vinyl methyl oxazolidinone; and a monomer having at least two vinyl ether groups.

The embodiment of the invention discloses a sulfide solid electrolyte and a preparation method thereof and a supercapacitor, the sulfide solid electrolyte comprises an organic-inorganic composite film generated by a curing reaction of a raw material system, the raw material system comprises a first monomer, a second monomer, a lithium salt, a siloxane prepolymer and an initiator, the first monomer is N, N-dimethylformamide, and the second monomer is N, N-dimethylformamide. The first monomer is N, N '-1, 3-propanediyl bis (oxazolidine-2 ketone), and the second monomer is 4, 4'-thiobisphenol diglycidyl ether. According to the embodiment of the invention, the sulfide solid electrolyte based on a composite system of N, N '-1, 3-propanediyl bis (oxazolidine-2 ketone) and 4, 4'-thiobisphenol diglycidyl ether is combined with the modification effect of the siloxane prepolymer and optimized process parameters, so that the defects in the prior art can be effectively overcome.