201 results about "Oxazolidine" patented technology

The invention relates to the technical field of flame retardance, and discloses a flame-retardant coating and a preparation method thereof.The flame-retardant coating is obtained by adding phenolic resin, polycarbonate, phosphorus-containing modified phenolic resin, boric acid-containing benzoxazine, an organic silicon resin defoaming agent, a propylene glycol film-forming agent and water into a stirrer and stirring. The flame-retardant coating contains a large amount of anacardol, long chains in the anacardol can also be crosslinked to form a net-shaped structure, a net-shaped carbon skeleton structure is formed under high-temperature carbonization, degradation products are inhibited during combustion, and the flame-retardant coating has good fire resistance; wherein oxazolidinone generated by reaction of an epoxy group of epoxidized phenolic resin and an isocyanate group of hexamethylene diisocyanate is a heterocyclic ring with very high heat resistance and also plays a role in synergistic fire resistance; the flame-retardant coating contains a large amount of phosphorus elements, sulfur elements and nitrogen elements, has a good flame-retardant effect, and achieves a synergistic flame-retardant effect.

The invention provides a polyurethane waterproof coating, a preparation method and a waterproof product. The polyurethane waterproof coating comprises the following raw materials in parts by weight: 206 parts of a polyurethane prepolymer; the polyurethane prepolymer is formed by reaction of hydroxyl-terminated polybutadiene acrylonitrile, organic silicon dihydric alcohol, polyether polyol and polyisocyanate; and 3 to 7 parts of oxazolidine end-capped modified resin based on 206 parts of the polyurethane prepolymer; 6-12 parts of a latent curing agent; 40 to 85 parts of an epoxy plasticizer; and 130 to 300 parts of an additive. According to the polyurethane waterproof coating, organic silicon dihydric alcohol, hydroxyl-terminated polybutadiene acrylonitrile and polyisocyanate react to form an NCO-terminated prepolymer, oxazolidine-terminated modified resin contains terminal group oxazolidine, and the terminal group oxazolidine is hydrolyzed to release secondary hydroxyl and amino to participate in the reaction; the peeling strength of the waterproof material formed by compounding the polyurethane coating and the coiled material is improved.

The invention provides application of 3-methyl-2-oxazolidinone as a nitrification inhibitor and a nitrification inhibition method, and relates to the technical field of soil treatment. Specifically, the invention relates to application of 3-methyl-2-oxazolidinone as a nitrification inhibitor in soil treatment and / or sewage treatment and inhibition of nitrosation activity of ammonia oxidizing bacteria. The method for inhibiting nitrification comprises the step of treating soil or water containing ammonium nitrogen and ammonia oxidizing bacteria by using 3-methyl-2-oxazolidinone. The concentration of the 3-methyl-2-oxazolidinone is not less than 0.01% w / v by taking the volume of the soil or the water body as 100%. The nitrification inhibition activity of the 3-methyl-2-oxazolidinone is found, so that the variety selection of nitrification inhibitors is enriched.

The present application discloses a one-component solvent-free epoxy-modified polyurethane waterproof coating, its preparation method and a waterproof product. The coating comprises the following raw material components in parts by weight: polyether diol, 100 parts by weight; polyether triol, 30 - 80 parts by weight; epoxy vegetable oil plasticizer, 80 - 120 parts by weight; pigments and fillers, 200 - 350 parts by weight; diisocyanate, 14 - 20 parts by weight; modified epoxy resin A, including a terminal epoxy group and an epoxyalkyl acrylate monomer-derived chain segment, 9 - 17 parts by weight; hydroxyoxazoline, 2 - 11 parts by weight, and the hydroxyoxazoline is an oxazoline compound containing one active hydroxyl group; active diluent, 70 - 100 parts by weight; defoamer, 1 - 3 parts by weight; dispersant, 0.1 - 0.5 parts by weight; latent curing agent, 12 - 41 parts by weight; catalyst, 0.4 - 1.8 parts by weight. The above coating can effectively improve the problem of poor adhesion strength retention rate of traditional polyurethane waterproof coatings after being soaked in water, and the product has excellent performance.

The invention relates to a bio-based environment-friendly breathable insole and a production process thereof, and belongs to the technical field of polymer foaming materials. The insole is formed by foaming a polyurethane foaming material, and is prepared from the following components in parts by weight: 100 parts of polyurethane prepolymer, 9 to 14 parts of reinforced bio-based filler, 0.2 to 0.3 part of catalyst, 0.4 to 0.5 part of foam stabilizer, 0.7 to 0.9 part of pore opening agent, 1.1 to 1.3 parts of cross-linking agent and 6.5 to 8.5 parts of water, the reinforced bio-based filler is kept stable at the initial water system foaming temperature, formation of complete foam holes is facilitated, the reinforced bio-based filler is dispersed in hole walls, in the subsequent high-temperature foaming environment, an oxazolidine structure on the surface of the reinforced bio-based filler is hydrolyzed to generate active groups, and the active groups are cross-linked with the polyurethane prepolymer again, so that the foaming performance of the reinforced bio-based filler is improved. The bonding strength of the lignin fiber and a polyurethane macromolecular chain is enhanced, and the foam hole wall is enhanced, so that the foam hole structure is stable, and the mechanical strength and the rebound rate of the material are remarkably improved.

The invention provides a cationic waterborne epoxy hardener without containing free amine and a preparation method thereof, and relates to the technical field of epoxy hardeners, the method comprises the following steps: 1) mixing small molecular aldehyde and hydroxyethyl diethylenetriamine for reaction to obtain oxazolidine and aldimine terminated modified amine; (2) carrying out reaction on the modified amine and polyfunctional epoxy resin to obtain modified oxazolidine and aldimine-terminated modified resin amine; 3) mixing the modified oxazolidine and aldimine terminated modified resin amine, monofunctional glycidyl ether and water for reaction to obtain terminated modified resin amine; and 4) adding small molecular acid to neutralize the terminated modified amine, and transferring water to obtain the cationic waterborne epoxy curing agent without free amine. The paint film can be endowed with excellent boiling water resistance, acid and alkali resistance, neutral salt mist resistance and the like, the preparation process is simple, the production cost is low, and the paint is suitable for large-scale industrial application.

The invention belongs to the technical field of electrolyte, and particularly relates to electrolyte and a secondary battery. The electrolyte comprises a water-removing and acid-inhibiting additive, the mass percent of the water-removing and acid-inhibiting additive is 0.05%-2.2% by taking the total mass of the electrolyte as 100%, the water-removing and acid-inhibiting additive comprises compounds with structures shown in a formula II and a formula III, the compound with the structure shown in the formula II is 3-ethyl-2-methyl-2-(3-methylbutyl)-1, 3-oxazolidine, and the compound with the structure shown in the formula III is 3-ethyl-2-methyl-2-(3-methylbutyl)-1, 3-oxazolidine. The compound with the structure as shown in the formula III is 3-butyl-2-(1-ethyl amyl)-1, 3-oxazolidine. The mass ratio of the compound with the structure shown in the formula II to the compound with the structure shown in the formula III is (1: 2)-(1: 4). The formula II and the formula III are compounded according to the proportion of (1: 2)-(1: 4), the overall performance of the additive can be synergistically optimized, the formula II provides rapid initial acid inhibition response, and the formula III ensures lasting later protection, so that the long-acting period from formation to long-term circulation of the battery is covered.

To provide a one-pack moisture-curable urethane resin composition that excels in storage stability and curability as one liquid, and exhibits sufficiently high weather resistance and impact resistance after curing, and a coating material prepared using the same.SOLUTION: Disclosed is a one-pack moisture-curable urethane resin composition comprising a urethane prepolymer and oxazolidine, wherein the urethane prepolymer is synthesized from a polyisocyanate and a polyol, which comprises a polycarbonate polyol (PC) and an acrylic polyol (AC) with a hydroxyl value of 60-150 mgKOH / g. Also disclosed is a coating material comprising the one-pack moisture-curable urethane resin composition and an aromatic solvent and / or an ether-based solvent.SELECTED DRAWING: None

The invention discloses a modified nylon 66 material and a preparation method thereof, and belongs to the technical field of high polymer materials. The modified nylon 66 material is prepared from the following raw materials in parts by mass: 100 to 120 parts of modified nylon 66 resin, 20 to 30 parts of reinforced resin and 1 to 5 parts of antioxidant. The raw materials are mixed, fused and granulated to obtain the modified nylon 66 material. Wherein the modified nylon 66 resin contains an oxazolidinone ring and a silica group. According to the invention, an isocyanate compound and organosiloxane of epoxy groups are added in the polymerization stage of nylon 66 resin, and an oxazolidinone ring and a silica group are introduced while a polymerization reaction is accelerated, so that on one hand, the oxazolidinone ring and the silica group can be utilized to enhance the heat resistance and hydrolysis resistance of the material, and the nylon material is modified from a polymerization end; and on the other hand, the compatibility with reinforced resin can be improved, the effect of the reinforced material is fully exerted, and the mechanical property and hydrolysis resistance of the modified nylon material are improved.

The purpose of the present invention is to provide a prepreg which uses a resin composition that can be cured in a short period of time and is capable of suppressing resin flow during molding, and which has high workability. A prepreg characterized in that the prepreg contains an epoxy resin composition and reinforcing fibers, the epoxy resin composition containing component (A): a urea compound; component (B): a thermoplastic resin; component (C): an epoxy resin having an oxazolidinone structure; and component (D): a bisphenol epoxy resin that is solid at 25 DEG C, and satisfies the following conditions (1) and (2). Condition (1): The minimum viscosity of the epoxy resin composition measured by a rheometer under the condition of 2 DEG C / min is in the range of 3.0-6.0 Pa.s. Condition (2): the gelation time value of the epoxy resin composition, as measured under the condition of 145 DEG C by CURELASTOMETER (Registered Trademark), is in the range of 2.0-5.0 min.

A process for producing a thermoplastic polyoxazolidinone comprising copolymerizing a diisocyanate compound (A) with a bisepoxide compound (B) in the presence of a specific a quaternary ammonium, quaternary phoshonium and / or quaternary stibonium-based catalyst (C), a compound (D), a compound (F) wherein compound (D) and compound (F) independently comprises at least one of a monofunctional isocyanate, a monofunctional epoxide, a cyclic carbonate, a monofunctional alcohol, a monofunctional amine optionally in a solvent (E), and wherein the process is in the absence of a solvent (G) with a boiling point higher than 200° C., preferably higher than 190° C. and more preferably higher than 180° C. at 1 bar (absolute). The invention is also related to the resulting thermoplastic polyoxazolidinone.

This invention provides an inkjet composition set that exhibits excellent blocking resistance, adhesion, tackiness, and shrinkage properties. [Solution] A radiation-curable inkjet ink composition comprising a polyfunctional monomer with three or more functions and 5-methyl-3-vinyloxazolidine-2-one, wherein the content of 5-methyl-3-vinyloxazolidine-2-one is less than 50% by mass of the total amount of the ink composition, the content of monofunctional monomers is 60% by mass or more of the total amount of polymerizable compounds, and the content of polyfunctional monomers with three or more functions is more than 1% by mass of the total amount of the ink composition.

The ether-bond-containing bisoxazolidine latent curing agent is obtained through a reaction of 3-hydroxyethyl-1, 3-oxazolidine, and is characterized in that a molecular structure contains two oxazolidine rings connected through an ether bond, and the ether-bond-containing bisoxazolidine latent curing agent is a bisoxazolidine latent curing agent. When in use, the polyurethane resin is subjected to ring opening when meeting moisture to generate a reaction group, and the reaction group and an isocyanate group are subjected to a chain extension cross-linking reaction to form a three-dimensional network structure. Compared with a traditional ester group connected bisoxazolidine latent curing agent, the novel bisoxazolidine latent curing agent can endow a polyurethane product with better toughness, the weather resistance of the polyurethane product is improved, and the application range of the polyurethane product is expanded.

The invention belongs to the field of pharmacology, and discloses a crystal form I of an oxazolidinone antibacterial candidate new drug OTB-658, a preparation method of the crystal form I, a composition of the crystal form I and application of the crystal form I. Specifically, the invention relates to a crystal form I of N-(((3S, 3aS)-8-fluoro-1-oxo-7-thiomorpholinyl-3a, 4-dihydro-1H, 3H-benzo [b] oxazole [3, 4-d] [1, 4] oxazine-3-yl) methyl) acetamide, namely OTB-658, and a preparation method thereof. The OTB-658 crystal form I is used as an active pharmaceutical ingredient to prepare drugs for treating and / or preventing bacteria, especially mycobacterium tuberculosis infectious diseases. # imgabs0 #

The invention relates to the technical field of medicines, in particular to fused tricyclic substituted isoxazolidinyl urea derivatives, pharmaceutically acceptable salts, stereoisomers, pharmaceutical compositions and application thereof. The structure of the fused tricyclic substituted isoxazolidinyl urea derivative is as shown in a formula (I). The fused tricyclic substituted isoxazolidinyl urea derivative disclosed by the invention has obvious TrkA kinase and cell inhibition activity and selective inhibition activity.

Disclosed are compositions and methods for the treatment of tuberculosis and other mycobacterial and gram-positive bacterial infections. These compositions comprise highly potent and selective oxazolidinones encapsulated with high efficiency to maximize the potential for low-toxicity drug delivery and are stable in the presence of plasma. The compositions are long-circulating and retain their encapsulated drug while in circulation following intravenous delivery to allow effective accumulation at the site of bacterial or mycobacterial infection. The high doses achievable and the long-circulating nature of the drug combined with the high stability of the formulation allow for a reduction in the frequency of administration compared to the once-daily or twice-daily administration of other drugs commonly used to treat these infections.

Disclosed is a preparation method, wherein a compound of formula (I) and a compound of formula (II) are used as starting materials to synthesize an oxazolidinone compound in the presence of a catalyst. Further disclosed is a use of a non-alkaline lithium salt and / or a quaternary ammonium salt as a catalyst in the synthesis of an oxazolidinone compound.

A method for producing thermoplastic polyoxazolidinone includes copolymerizing a diisocyanate compound (A) with a diepoxide compound (B) in a solvent (E) optionally in the presence of a specific quaternary ammonium, quaternary phosphorus, and / or quaternary antimony-based catalyst (C), compound (D), and compound (F), wherein compound (D) and compound (F) independently comprise at least one of a monofunctional isocyanate, a monofunctional epoxide, a cyclic carbonate, a monofunctional alcohol, and a monofunctional amine, and wherein the method is free of solvents (G) with a boiling point above 200°C (absolute) at 1 bar, preferably above 190°C, and more preferably above 180°C. The invention also relates to the resulting thermoplastic polyoxazolidinone.

The application discloses a preparation method of zolmitriptan, relates to the technical field of drug synthesis, and comprises the following steps: adding compound 1 and reagent 1 into solvent 1 to perform a first reaction to obtain compound 2; adding the compound 2, reagent 2 and reagent 3 into solvent 2 to perform a second reaction to obtain compound 3 and the like. Compared with the prior art, the application provides a novel synthetic route for preparing zolmitriptan, the route uses L-4-bromophenylalanine as a starting material, and new synthetic steps are adopted, such as using reagent 5, such as a t-butyl alcohol metal salt and sodium hydride, to construct the oxazolidinone structure in zolmitriptan and using a coupling reaction to construct the indole ring in zolmitriptan, so that the yield of the obtained target product is significantly improved, the use of high-toxicity and high-risk reagents in the existing synthetic route is effectively avoided, and a mild, efficient, green and environmentally-friendly synthetic route for preparing zolmitriptan is provided.

The invention provides an epoxy-terminated polyurethane flexibilizer and a preparation method and application thereof, and belongs to the technical field of epoxy composites.The epoxy-terminated polyurethane flexibilizer is prepared from polyol, isocyanate, a chain extender, a catalyst, metal salt and epoxy resin, and the chain extender comprises hydroxybenzoxazine. The epoxy-terminated polyurethane toughening agent provided by the invention contains carbamate groups, benzoxazine groups and five-membered oxazolidinone structures, the groups have strong polarity, and due to the introduction of the five-membered oxazolidinone and the benzoxazine groups, the toughening agent has excellent stability at a high temperature and in a salt mist old chemical process, so that the toughness of the toughening agent is improved, and the service life of the toughening agent is prolonged. The toughening agent is added into the epoxy resin structural adhesive, the adhesion of the epoxy resin structural adhesive to metal materials can be improved while the glass transition temperature is not reduced, and the toughening agent further contains a polyether chain segment which can improve the low-temperature impact resistance of the epoxy resin structural adhesive.

The invention discloses a preparation method of an azacyclo-bis (fluorosulfonyl) imide salt derivative, which comprises the following steps of: 1, mixing an azacyclo-compound, a methylation reagent, an ethylation reagent, bis (fluorosulfonyl) imide salt and inorganic alkali in a polar organic solvent, heating, and filtering after complete reaction to obtain crude filtrate containing the azacyclo-bis (fluorosulfonyl) imide salt; the nitrogen heterocyclic compound is selected from one of oxazolidine, 4-cyano piperidine, 4-fluoro piperidine, 4, 4-difluoro piperidine and 3-cyano piperidine; the bis (fluorosulfonyl) imide salt is selected from one of lithium bis (fluorosulfonyl) imide and potassium bis (fluorosulfonyl) imide; and 2, adding an inert organic solvent into the crude product filtrate for crystallization, and performing vacuum drying to obtain a finished product. The method has the advantages that the operation steps are few, the synthesis efficiency is greatly high, the process is greatly simplified, and the preparation cost is effectively reduced.

The present invention relates to a process for the enantioselective preparation of chiral 4-substituted 2-oxazolidinones of formula (la) or (lb) via asymmetric hydrogenation of the corresponding 4-substitued 2-oxazolones of formula (II) using a combination of palladium or nickel and a chiral bidentate P-ligand as catalyst. The oxazolidinones can then be converted to important chiral building blocks such as enantiopure chiral aminoalcohols and haloamines via decarboxylative ring opening reaction.

The invention discloses p-toluenesulfonic acid 8-tert-butyl diphenyl silyloxy-7-methyl octyl ester as well as a synthesis method and application thereof, and relates to the technical field of biopesticides. The preparation method comprises the following steps: taking 8-bromocaprylic acid as an initial raw material, and firstly reacting with t-BuOK and 18-crown ether-6; then reacting with pivaloyl chloride to generate acid anhydride, and then carrying out acylation reaction with 4-benzyl oxazolidine-2-ketone; then carrying out diastereoselective methylation; then, NaBH4 reduction is carried out; carrying out hydroxyl protection; then carrying out hydroboration oxidation reaction; and then carrying out TsCl sulfonylation, so as to synthesize the p-toluenesulfonic acid-8-tert-butyl diphenyl silyloxy 7-methyl octyl ester. The optical purity of the (S)-p-toluenesulfonic acid 8-tert-butyl diphenyl silyloxy-7-methyl octyl ester synthesized in the invention reaches 98%, and the optical purity of the (R)-p-toluenesulfonic acid 8-tert-butyl diphenyl silyloxy-7-methyl octyl ester synthesized in the invention also reaches 98%.

Provided are methods of forming a three-dimensional object that include irradiating a resin composition of the invention with actinic radiation or light, thereby forming a three-dimensional intermediate, and then further reacting the three-dimensional intermediate to form the three-dimensional object. In some embodiments, resin compositions of the invention include a polyisocyanate such as, e.g., a reactive blocked polyisocyanate; a polyfunctional epoxy compound; a photoinitiator; optionally, a catalyst; optionally, a polyol and / or a polyamine chain extender; optionally, a reactive diluent; optionally, a pigment or dye; and optionally, a filler. Related resin compositions are also provided herein. Further, provided are three-dimensional objects formed by a method of the invention, including, e.g., objects formed of a polymer having at least one oxazolidinone linkage.

The invention belongs to the technical field of skin microorganism regulation and control and daily chemical products, and relates to application of alkyl oxazolidinone in regulation and control of skin microbial flora and a product containing the alkyl oxazolidinone. The invention finds that the alkyl oxazolidinone, especially C8-14 alkyl oxazolidinone, has a remarkable inhibition effect on regulating and controlling skin microbial flora, especially on malassezia furfur and propionibacterium acnes; the compound is widely applied to preparation of products for removing dandruff, relieving itching and / or relieving acne and preparation of medicines for treating and / or preventing skin diseases caused by imbalance of skin microbial flora.

The invention belongs to the technical field of caulking agents, and particularly relates to a polyurethane caulking agent and a preparation method thereof.The polyurethane caulking agent is prepared from, by mass, 35%-40% of siloxane modified dendritic polyether tetrahydric alcohol, 35%-40% of diphenylmethane diisocyanate, 5%-10% of plasticizer chlorinated paraffin, 3%-4% of 2-phenyl-5-trifluoromethyl-1, 3-oxazolidine latent curing agent, 1%-2% of foam stabilizer and 1%-2% of catalyst 2. 0.5-0.8% of 2, 2 '-dimorpholinyl diethyl ether, 5-8% of dimethyl ether and 5-8% of propane and butane. According to the polyurethane joint mixture, the 2-phenyl-5-trifluoromethyl-1, 3-oxazolidine latent curing agent is added, in the curing process, the latent curing agent reacts with water in advance of the diphenylmethane diisocyanate to form an amine substance, amido in the amine substance reacts with the diphenylmethane diisocyanate to generate a macromolecular polymer, curing of the polyurethane joint mixture is achieved, and the polyurethane joint mixture has the advantages that the curing effect is good; the curing time can be shortened, and the construction speed is increased.

The invention relates to fluorine-containing isoxazolidine-5-ketone as well as a synthesis method and anti-tumor application thereof. According to the synthesis method, gem-difluorocycloacrylimide and nitrone are taken as substrates, Ni (ClO4) 2.6 H2O is taken as a catalyst, (+ / -)-2, 2 '-(propane-2, 2-diyl) bis (4-phenyl-4, 5-dihydrooxazole) is taken as a ligand (L) in an organic solvent, cycloaddition isomerization reaction is carried out at about 30 DEG C, and the fluorine-containing isoxazolidine-5-ketone compound is obtained. And the fluorine-containing isoxazolidine-5-ketone is obtained through preparation. The method is mild in reaction condition, capable of being well compatible with various functional groups and high in yield, and the product further has certain biological activity and can inhibit proliferation of cancer cells. The invention discloses the realization of the cycloisomerization reaction of the gem-difluorocyclopropene and the nitrone for the first time, provides a new idea for the synthesis of the fluorine-containing isoxazolidine-5-ketone and the derivative thereof, and has a good application prospect in the fields of medicines and synthesis.

The invention relates to the technical field of coatings, in particular to dual-curing conformal coating as well as a preparation method and application thereof. The dual-curing three-proofing paint is composed of siloxane containing oxazolidinyl groups, a UV oligomer containing isocyanate groups, a diluting monomer, a water removal agent, a photoinitiator, a wetting agent, a catalyst and the like. Wherein the siloxane containing the oxazolidinyl group has two functional groups of long carbon chain oxazolidine and siloxane, the long carbon chain oxazolidine can realize rapid moisture curing of oligomer and does not generate volatile harmful substances, and meanwhile, hydrolysis residues of the long carbon chain oxazolidine can plasticize the conformal coating and reduce adhesion loss caused by shrinkage. On the other hand, siloxane groups can form a stronger physical or chemical action with a base material, so that the adhesive force to the base material is improved. In conclusion, the three-proofing paint has excellent low surface tension and high wettability, can effectively wet the polluted surface of the PCB and form interaction, has the characteristics of excellent adhesive force, salt mist resistance, high flexibility and the like, and has very high market application value.

The invention relates to a thermal insulation composite fabric and a production process thereof, belonging to the technical field of functional fabrics. The thermal insulation composite fabric is composited with a densely woven base fabric and a thermal insulation adhesive. The thermal insulation adhesive uses aerogel micropowder as thermal insulation particles, is modified by introducing epoxy groups through a silane coupling agent KH560, is ring-opened by 2-(1-methylethyl)-3-oxazoline ethanol and epoxy groups, introduces oxazolidine structures on the surfaces of aerogel microparticles, and synthesizes a polyurethane prepolymer containing a polyether segment from polyether diol and diisocyanate as an adhesive material. During the fumigation curing process, the polyether segment is hydrophilic and preferentially infiltrated and diffused, and the oxazolidine structure on the surface of the modified aerogel powder is promoted to hydrolyze, expose active amine groups and hydroxyl groups, and promote the cross-linking of isocyanate in the prepolymer in the near-surface layer of the modified aerogel powder, so that the aerogel microparticles are uniformly fixed with the polyether segment of the prepolymer as a template, and are segmented in the adhesive layer to form intricate and tortuous heat conduction channels, thereby increasing the thermal resistance of the adhesive layer and having a good thermal insulation effect.