60 results about "Oxazolidone" patented technology

The invention discloses a halohydrin dehalogenase mutant and application of the halohydrin dehalogenase mutant in preparation of (R)-4-phenyl-2-oxazolidinone, and belongs to the technical field of enzyme engineering and chemical engineering, amino acid residues of wild type halohydrin dehalogenase are mutated, and the halohydrin dehalogenase mutant with high enzyme activity and high stereoselectivity is screened out. The halohydrin dehalogenase mutant provided by the invention has high enzyme activity and high stereoselectivity in the application of catalyzing (S)-2-phenyl ethylene oxide to be converted into (R)-4-phenyl-2-oxazolidinone, the catalytic efficiency of the mutant T126L / F170M can reach 1.7 times of that of wild halohydrin dehalogenase, and the halohydrin dehalogenase mutant has extremely high industrial application value.

The invention provides an epoxy-terminated polyurethane flexibilizer and a preparation method and application thereof, and belongs to the technical field of epoxy composites.The epoxy-terminated polyurethane flexibilizer is prepared from polyol, isocyanate, a chain extender, a catalyst, metal salt and epoxy resin, and the chain extender comprises hydroxybenzoxazine. The epoxy-terminated polyurethane toughening agent provided by the invention contains carbamate groups, benzoxazine groups and five-membered oxazolidinone structures, the groups have strong polarity, and due to the introduction of the five-membered oxazolidinone and the benzoxazine groups, the toughening agent has excellent stability at a high temperature and in a salt mist old chemical process, so that the toughness of the toughening agent is improved, and the service life of the toughening agent is prolonged. The toughening agent is added into the epoxy resin structural adhesive, the adhesion of the epoxy resin structural adhesive to metal materials can be improved while the glass transition temperature is not reduced, and the toughening agent further contains a polyether chain segment which can improve the low-temperature impact resistance of the epoxy resin structural adhesive.

To provide a photosensitive resin composition that has excellent gas barrier performance against outgassing released from an overcoat layer during heating.SOLUTION: A photosensitive resin composition comprises (b) an alkali-soluble resin, (c) a photopolymerization initiator, and (d) an ethylenically unsaturated compound, wherein the alkali-soluble resin (b) contains an alkali-soluble resin (b-1) having an isocyanurate ring, a (meth)acryloyloxy group, a carboxyl group, and an oxazolidone ring.SELECTED DRAWING: None

The invention discloses a halohydrin dehalogenase mutant and its application in preparing (R)-4-phenyl-2-oxazolidinone, belongs to the field of enzyme engineering and chemical engineering technology, the amino acid residues of wild-type halohydrin dehalogenase are mutated, and halohydrin dehalogenase mutants with high enzyme activity and high stereoselectivity are screened out. The halohydrin dehalogenase mutant provided by the present invention has high enzyme activity and high stereoselectivity in the application of catalyzing (S)-2-phenyloxirane to convert (R)-4-phenyl-2-oxazolidinone, and the catalytic efficiency of mutant T126L / F170M can reach 1.7 times that of wild-type halohydrin dehalogenase, with extremely high industrial application value.

The invention belongs to the technical field of material synthesis catalysis, and particularly relates to a Cu-based defect type metal organic framework, a preparation method thereof and application of the Cu-based defect type metal organic framework in carbon dioxide catalytic conversion. The Cu-based defect type metal organic framework is prepared from triaminoguanidine hydrochloride, a pyrazole ring trinuclear cuprous complex ([Cu3 (PyCA) 3]) and imidazole-2-formaldehyde through a Schiff base condensation polymerization reaction. The Cu-based defect type metal organic framework prepared by the method can efficiently catalyze carbon dioxide and propargyl amine compounds to synthesize oxazolidinone heterocyclic compounds under normal pressure and cocatalyst-free reaction conditions, and has good recycling capability and industrial production potential.

This invention discloses a method for preparing and applying a highly flexible, high-temperature resistant photosensitive resin. The preparation method includes synthesizing an epoxy-containing acrylate resin and a photosensitive resin containing oxazolidinone bonds. A two-step reaction is used to synergistically improve the flexibility and heat resistance of the photosensitive resin: The first step employs RAFT living radical polymerization to precisely control the molecular weight of the acrylate copolymer segments, introducing glycidyl methacrylate to provide side-chain epoxy groups, and adjusting the balance between chain flexibility and rigidity using butyl acrylate and isobornyl ester to obtain a narrowly distributed epoxy-containing acrylate intermediate. The second step utilizes the epoxy group and diphenylmethane diisocyanate to undergo a cyclization addition reaction under a catalyst, generating a highly thermally stable oxazolidinone five-membered heterocyclic structure to impart excellent high-temperature resistance to the resin. The residual isocyanate groups are capped with hydroxy acrylate to introduce photosensitive double bonds, achieving a photosensitive resin with both good adhesion and temperature resistance.

The application discloses a sulfide solid electrolyte, a preparation method thereof and a super capacitor. The sulfide solid electrolyte comprises an organic-inorganic composite film generated by a curing reaction of a raw material system. The raw material system comprises a first monomer, a second monomer, a lithium salt, a siloxane prepolymer and an initiator. The first monomer is N,N'-1,3-propanediyl bis(oxazolidine 2-ketone), and the second monomer is 4,4'-thiobisphenol diglycidyl ether. The application is based on the composite system sulfide solid electrolyte of N,N'-1,3-propanediyl bis(oxazolidine 2-ketone) and 4,4'-thiobisphenol diglycidyl ether, and the modification of the siloxane prepolymer and the optimized process parameters, so that the defects of the prior art can be effectively solved.

This invention provides a waterborne epoxy-isocyanate hybrid nano-heavy-duty anti-corrosion coating and its application method, relating to the field of heavy-duty anti-corrosion coating technology. The waterborne epoxy-isocyanate hybrid nano-heavy-duty anti-corrosion coating provided by this invention includes a primer, which is composed of component A containing epoxy, component B containing isocyanate, and component C containing an aqueous catalyst in a specific ratio. The heavy-duty anti-corrosion coating provided by this invention achieves precise control of the sequential reaction between isocyanate and epoxy groups through the aqueous catalyst, generating in-situ polyurea chains, oxazolidinone five-membered rings, isocyanurate six-membered rings, and amorphous nano-silica particles, forming a highly homogeneous organic-inorganic hybrid copolymer interpenetrating network. The resulting coating possesses both ultra-high mechanical strength and superior chemical resistance and corrosion resistance, is safe and environmentally friendly, and can be widely used for long-term heavy-duty anti-corrosion protection in harsh corrosive environments in fields such as petrochemicals, energy, shipbuilding, marine engineering, infrastructure, and military equipment.

This invention provides poly(hydroxyoxazolidinone) compounds (PHOx) corresponding to formula (I) or formula (II): wherein R1 ’ R2 ’ Each of the following elements independently represents a C1-C20 alkyl group, preferably a C1-C10 alkyl group, more preferably a C1-C3 alkyl group, and most preferably a methyl group; and -R3 and -R4 independently represent hydrogen or a C1-C20 alkyl group, preferably a C1-C10 alkyl group, more preferably a C1-C3 alkyl group, and most preferably a methyl group; and -R5 and -R5 ’ R6, R6 ’ Each of the following groups independently represents hydrogen or a C1-C20 alkyl group, preferably a C1-C10 alkyl group, more preferably a C1-C3 alkyl group, most preferably methyl, or aryl, preferably phenyl; and A is an organic linking group selected from straight-chain, branched, saturated, unsaturated, cyclic and / or acyclic aliphatic, aromatic or arylaliphatic hydrocarbon groups, preferably having 1 to 20, more preferably 1 to 12, most preferably 1 to 8 carbon atoms, and optionally further comprising one or more functional groups selected from ethers, esters, amides, amines, carboxyl groups, sulfur, halogens and / or carbamates; and optionally, A, R3 and R4 in formula (I) are linked to each other to form a cyclic structure; and optionally, R5 and R5 in formula (II) are linked to each other to form a cyclic structure. ’ , and / or R6 and R6 ’ They are interconnected to form a ring structure; and -R7 is a polymer chain selected from polysiloxanes or polyethers; and n is an integer from 2 to 100, preferably from 2 to 50, more preferably from 2 to 25, and most preferably from 2 to 15. The present invention also provides a process for forming the PHOx compound of the present invention and a poly(alkylene oxazolidinone) compound (POx) obtained by dehydrating the PHOx compound of the present invention. (I)(II).

The present invention discloses oxazolidinone compounds of Formula (I): (I) and pharmaceutically acceptable salts thereof, wherein A and E, are as defined herein. The present invention also relates to compositions which comprise at least one oxazolidinone compound of the invention. The invention also provides methods for inhibiting growth of mycobacterial cells as well as a method of treating mycobacterial infections by Mycobacterium tuberculosis comprising administering a therapeutically effective amount of an oxazolidinone of the invention and / or a pharmaceutically acceptable salt thereof, or a composition comprising such compound and / or salt.

A radiation-curable ink jet ink composition includes a photoinitiator, a nitrogen-containing monofunctional polymerizable compound, and a cyclic ether-containing monofunctional polymerizable compound, in which the photoinitiator includes ethyl phenyl(2,4,6-trimethylbenzoyl)phosphinate, and the nitrogen-containing monofunctional polymerizable compound includes N-vinyl methyl oxazolidinone.

The embodiment of the invention discloses a sulfide solid electrolyte and a preparation method thereof and a supercapacitor, the sulfide solid electrolyte comprises an organic-inorganic composite film generated by a curing reaction of a raw material system, the raw material system comprises a first monomer, a second monomer, a lithium salt, a siloxane prepolymer and an initiator, the first monomer is N, N-dimethylformamide, and the second monomer is N, N-dimethylformamide. The first monomer is N, N '-1, 3-propanediyl bis (oxazolidine-2 ketone), and the second monomer is 4, 4'-thiobisphenol diglycidyl ether. According to the embodiment of the invention, the sulfide solid electrolyte based on a composite system of N, N '-1, 3-propanediyl bis (oxazolidine-2 ketone) and 4, 4'-thiobisphenol diglycidyl ether is combined with the modification effect of the siloxane prepolymer and optimized process parameters, so that the defects in the prior art can be effectively overcome.

The invention provides a novel carrier-free catalysis strategy, the in-situ carboxylation cyclization reaction of ultralow-concentration carbon dioxide and propargylamine is realized by utilizing low-cost silver carbonate under the conditions of normal temperature and normal pressure, and the oxazolidinone compound with important industrial value is efficiently synthesized. The catalytic system not only can efficiently convert carbon dioxide in a low concentration range of 5 vol.% to 35 vol.%, but also can directly convert carbon dioxide as low as 0.04 vol.% in air to generate oxazolidinone, the highest yield can reach 97%, and good substrate applicability is shown. By constructing a circular reaction device, the concentration of carbon dioxide in simulated gas can be reduced from 15 vol.% to 3 vol.%, and meanwhile, the average yield of oxazolidinone is maintained to reach 92%.

The invention relates to the technical field of high polymer materials, and discloses a preparation method and process of a high-temperature-curing and high-temperature-resistant polyurethane sealant, and the preparation method comprises the following steps: preparing an isocyanate-terminated polyurethane prepolymer; carrying out shear mixing on solid epoxy resin micro powder, a liquid separant incompatible with the prepolymer and a thixotropic agent to prepare thixotropic isolation paste; uniformly dispersing the paste in the prepolymer at the temperature lower than the softening point of the micro powder to construct a multi-phase suspension physical isolation system; when in use, the viscosity of the liquid separant is reduced by heating, rheological activation is carried out, the temperature is increased to be higher than the melting point of the micro powder after sizing, the micro powder is subjected to melting phase change to damage the isolation layer, and the micro powder reacts with the prepolymer under the action of the latent catalyst to generate a high-temperature-resistant oxazolidinone structure. By constructing a temperature-sensitive physical isolation structure, the contradiction among the storage stability, high-temperature rapid curing and heat resistance of the single-component polyurethane sealant is effectively solved, and the obtained sealant is good in constructability and high in mechanical strength after curing.

This invention belongs to the field of organic monomer synthesis technology, and relates to a method for preparing 3-(1-ethoxyethyl)oxazolidinone using magnetic nanoparticles supported by an acidic ionic liquid catalyst. The invention prepares magnetic nanoparticles via a co-precipitation method, uses 2-methylimidazolium, 3-chloropropyltriethoxysilane, and p-toluenesulfonic acid to prepare an acidic ionic liquid, and then loads the acidic ionic liquid onto the magnetic nanoparticles. Oxazolidinone and acetal are used as raw materials, and the magnetic nanoparticles supporting the acidic ionic liquid serve as the catalyst. After the reaction, the catalyst is magnetically filtered out, and 3-(1-ethoxyethyl)oxazolidinone is obtained by distillation. This invention uses magnetic nanoparticles supported by an acidic ionic liquid as the catalyst, which is easy to separate and can be recycled and reused multiple times. The synthesis reaction conditions of this invention are mild, the operation is simple, the cost is low, and the yield is high.

The invention relates to the technical field of thermoplastic polyurethane hot melt adhesives, and particularly discloses a modified curing reaction type PUR hot melt adhesive resin and a preparation method thereof. The PUR hot melt adhesive resin is prepared from the following raw materials: a diisocyanate compound, polycarbonate polyol, polyether polyol, glycidyl ether, a catalyst, an antioxidant and a filler, the diisocyanate compound is modified through glycidyl ether, and modified MDI which has an isocyanate group as a terminal group and contains an oxazolidinone structure is obtained; then the modified MDI containing the oxazolidinone structure is introduced into the PUR hot melt adhesive resin, so that the high temperature resistance and the toughness of the material are improved.

The present disclosure relates to oxazolidone-derived compounds (of formulas I, II, III and IV) and their use as pharmaceutical agent in the treatment, prevention or reduction of both acute and chronic pain. The mode of action disclosed herein allows oxazolidone and oxazolidone analogue compounds to act as analgesic through reduction of hyperactive firing of pain sensing neurons. Related to their high efficacy in the treatment of pain, these compounds are expected to selectively target voltage-activated K+ currents expressed in the small diameter dorsal root neurons (sdDRGns). Such findings, together with those showing that oxazolidone and oxazolidone analogue compounds act as activity dependent blockers also lead to very reduced side-effects. The results disclosed herein show that oxazolidone and oxazolidone analogue compounds described herein are a viable alternative to the already existing pharmaceutical compounds used in the treatment of pain.

This invention provides an amide-bridged organosilicon modified polymer and its preparation method, as well as a gel fracturing fluid and its preparation method and application, belonging to the field of petroleum development technology. The preparation method of the amide-bridged organosilicon modified polymer includes the following steps: adding acrylamide, 2-acrylamido-2-methylpropanesulfonic acid, acrylic acid, and 5-methyl-3-vinyloxazolidine-2-one to water, adjusting the pH of the system to 5.5-7.5, purging with nitrogen to remove oxygen, heating to the reaction temperature, and then adding 3-acrylamidopropyltrimethoxysilane to obtain a premix; adding an initiator to the premix to carry out the reaction; after the reaction is completed, washing, drying, and grinding to obtain the amide-bridged organosilicon modified polymer. When used to prepare a gel fracturing fluid, the resulting gel fracturing fluid exhibits excellent temperature resistance and shear strength, can be applied in reservoir environments up to 220℃, is easily broken in the reservoir, has low residue content, and causes minimal reservoir damage, showing great potential for field application in oilfields.

The present invention belongs to the field of medical technology and relates to a preparation method of chiral (R) 4 n-propyl dihydrofuran 2 (3H) ketone. The method first utilizes the acylation reaction of chiral oxazolidinone and n-valeryl chloride to introduce an alkyl side chain, and then reacts with diethyl oxalate under the action of sodium methoxide to introduce a chiral center, and then reduces the carbonyl group and sodium borohydride to reduce the amide to obtain a chiral side chain, and finally completes lactonization under the catalytic action of trifluoroacetic acid to obtain the target product. Compared with current synthetic methods, this route has mild reaction conditions, does not involve the use of reagents such as ultra-low temperature reaction and dangerous Grignard reagents and lithium salts, and post-processing is simple, and chiral oxazolidinone is recyclable, has the advantages of green and high efficiency, and is suitable for industrial production.

An object of the present invention is to provide a prepreg containing a resin composition which has an excellent elastic modulus and heat resistance, and which also has an excellent appearance including weather resistance and transparency, as well as to provide a fiber-reinforced composite material, a tubular fiber-reinforced composite material, a golf club shaft and a fishing rod, using the prepreg, and having excellent mechanical properties, heat resistance and appearance. As means to achieve the above-mentioned object, the present invention provides a prepreg including reinforcing fibers and a resin composition, wherein the resin composition contains the following component [A] to component [D]: component [A]: a novolac type epoxy resin; component [B]: an oxazolidone type epoxy resin; component [C]: one or both of a sorbitol type epoxy resin and a glycerol type epoxy resin; and component [D]: dicyandiamide; and wherein the resin composition satisfies the following requirement (1) to requirement (5): requirement (1): the content of the component [A] is from 20 to 50 parts by mass, with respect to 100 parts by mass of the total epoxy resin; requirement (2): the content of the component [B] is from 10 to 40 parts by mass, with respect to 100 parts by mass of the total epoxy resin; requirement (3): the content of the component [C] is from 10 to 40 parts by mass, with respect to 100 parts by mass of the total epoxy resin; requirement (4): the resin composition contains a total of 40 parts by mass or more of the component [B] and the component [C], in 100 parts by mass of the total epoxy resin; and requirement (5): the resin composition does not contain a component [E] which is a glycidylamine type epoxy resin, or in cases where the resin composition contains the component [E], the content thereof is 10 parts by mass or less with respect to 100 parts by mass of the total epoxy resin.

This active energy ray-curable adhesive composition for an optical film contains vinyl methyl oxazolidinone. This active energy ray-curable adhesive composition for an optical film has excellent adhesiveness even when used for affixing an optical film having ultraviolet absorption ability.

The invention belongs to the technical field of carbon dioxide capture and catalytic conversion, and particularly relates to a three-dimensional cobalt-based MOF material, a preparation method thereof and application of the three-dimensional cobalt-based MOF material in conversion of carbon dioxide into oxazolidinone derivatives. The preparation method comprises the following steps: mixing and dissolving 2, 5-bis (2-pyridyl)-1, 3, 4-thiadiazole and 2-aminoterephthalic acid in distilled water to obtain a solution A; dissolving cobalt perchlorate in an N, N-dimethylformamide solution to obtain a solution B; and mixing the solution A and the solution B, and carrying out hydrothermal reaction to obtain the three-dimensional cobalt-based MOF material. The material is used for converting carbon dioxide into an oxazolidinone derivative, efficient catalytic conversion of CO2 can be achieved, the requirement for reaction conditions is lowered, the product purity is improved, meanwhile, it is guaranteed that the catalyst can be repeatedly used for many times, and therefore application of the CO2 catalytic conversion technology in industrial production is promoted.

The invention discloses a preparation method of L-echinacea A and an acid salt thereof. The preparation method of the L-echinacea A acid salt comprises the following synthetic route. And carrying out alkalization treatment on the L-inclusion canine A acid salt, so as to obtain the L-inclusion canine. According to the invention, pyridinium salt and chiral N-acryloyl oxazolidinone are taken as initial raw materials, a (2R, 5R, 6S) core skeleton of the obtuseline A is selectively constructed through a 1, 3-dipolar cycloaddition reaction, then introduction of all carbon atoms in the obtuseline A is completed through processes of hydrogenation reduction, transamination, hydroboration reduction reaction, methylation and the like, and the novel preparation method of the obtuseline A is realized. The preparation method comprises the following steps: by taking L-echinokimene as a raw material, carrying out protection group replacement, oxidation rearrangement reaction, protection group removal and other processes to prepare L-echinokimene acid salt, and carrying out alkalization treatment on the L-echinokimene acid salt to obtain the L-echinokimene with optical activity, the whole route is simple and convenient, the yield is good, the selectivity is relatively good, and the reaction conditions are mild and controllable.

The invention provides a preparation method of a mercaptide-based ionic liquid catalyst and a method for capturing and converting CO2 by using the mercaptide-based ionic liquid catalyst. The mercaptide-based ionic liquid is prepared by carrying out simple neutralization reaction on mercaptan and organic alkali. The structural formula of the thiolate-based ionic liquid is as shown in formula (1): # imgabs0 #. Compared with the existing ionic liquid for capturing CO2, the thiolate-based ionic liquid not only has excellent CO2 capturing performance, but also is easy to desorb CO2. When the thiolate-based ionic liquid is used as a non-metal homogeneous catalyst to be applied to a cycloaddition reaction of carbon dioxide and ethylene oxide or propargylamine to generate cyclic carbonate and oxazolidinone, the thiolate-based ionic liquid shows excellent catalytic performance and stable recycling and reusing performance. The mercaptide-based ionic liquid integrates capture and conversion functions, can realize high-capacity capture, low-energy barrier release and efficient conversion of CO2, and has wide application in a CCUS technology.

This invention relates to the field of organic synthesis technology, specifically to a synthesis process for S-(+)-4-phenyl-2-oxazolidinone. The synthesis process for S-(+)-4-phenyl-2-oxazolidinone provided by this invention not only enables the recovery and utilization of organic solvents such as tetrahydrofuran and toluene, saving resources and reducing production costs, but also reduces environmental pollution. Furthermore, the S-(+)-4-phenyl-2-oxazolidinone synthesized by this invention has advantages such as high purity and high yield, effectively ensuring the grade and quality of S-(+)-4-phenyl-2-oxazolidinone. It appears as a white or off-white crystalline powder, readily soluble in DMSO, acetone, and ethanol.

The present disclosure relates to oxazolidone-derived compounds (of formulas I, II, III and IV) and their use as pharmaceutical agent in the treatment, prevention or reduction of both acute and chronic pain. The mode of action disclosed herein allows oxazolidone and oxazolidone analogue compounds to act as analgesic through reduction of hyperactive firing of pain sensing neurons. Related to their high efficacy in the treatment of pain, these compounds are expected to selectively target voltage-activated K+ currents expressed in the small diameter dorsal root neurons (sdDRGns). Such findings, together with those showing that oxazolidone and oxazolidone analogue compounds act as activity dependent blockers also lead to very reduced side-effects. The results disclosed herein show that oxazolidone and oxazolidone analogue compounds described herein are a viable alternative to the already existing pharmaceutical compounds used in the treatment of pain.

The application provides a method for synthesizing oxazolidinone compounds based on carbon dioxide and alcohol amine, a catalyst, oxazolidinone compounds prepared based on carbon dioxide and alcohol amine, and application of cerium-based composite oxides in preparation of oxazolidinone compounds based on carbon dioxide and alcohol amine. The method comprises the following steps: taking carbon dioxide and alcohol amine as raw materials, and allowing the alcohol amine to react with the carbon dioxide under the action of a solid catalyst to generate the oxazolidinone compounds; wherein the solid catalyst comprises cerium-based composite oxides, and the reaction process comprises liquid-phase carboxylation and cyclization dehydration. The method provided by the application can easily separate the catalyst from the product, and can make the alcohol amine have a high conversion rate.

The present disclosure provides methods of treating Alzheimer's disease and other disorders using (4R,5R)-5-(2-chlorophenyl)-4-(5-(phenylethynyl)pyridin-3-yl)oxazolidin-2-one (Compound 1).

This invention provides a method for synthesizing 3-cinnamyl oxazolidine-2-one derivatives. The method provided by this invention is a one-step synthesis of 3-cinnamyl oxazolidine-2-one derivatives. Compared with commonly used methods, it requires only one step to obtain the product and requires less catalyst, thus enabling a more efficient and environmentally friendly method to obtain the corresponding product.

A radiation-curable ink jet ink composition includes a nitrogen-containing monofunctional polymerizable compound and a photoinitiator, in which the nitrogen-containing monofunctional polymerizable compound includes N-vinyl methyl oxazolidinone, and the photoinitiator includes a high-molecular-weight photoinitiator having a molecular weight of 500 or greater.