267 results about "Hydrochloride" patented technology

This invention discloses an MPP pipe for power cables and its preparation method, relating to the field of polymer materials technology. The invention comprises, by weight, 80-90 parts of a toughening nucleating agent; 40-45 parts of an insulating nucleating agent obtained by in-situ composite and gradient temperature imidization treatment of a polyamic acid prepolymer prepared from hexagonal boron nitride nanosheets (prepared by surface modification with dopamine hydrochloride, followed by modification with octyltriethoxysilane) to obtain a silanized boron nitride suspension; 40-45 parts of melamine cyanurate; 2.1-2.4 parts of an antioxidant; 2.6-3 parts of a light stabilizer; 8-9 parts of a lubricant; and 1340-1500 parts of polypropylene. The introduction of the toughening nucleating agent and insulating nucleating agent in this invention effectively improves the flame retardancy, low-temperature rigidity-toughness balance, and aging resistance of the MPP pipe.

The application belongs to the technical field of dental antibacterial materials, and discloses a kind of nanometer composite antibacterial coating for dental material and preparation method thereof.Method: monomer modified arginine, monomer N-isopropyl acrylamide, monomer methyl hexyl acrylate, initiator azobisdimethylamino propanamide hydrochloride, dispersing agent cetyltrimethylammonium bromide and crosslinking agent N,N-methylene bis(acrylamide) are dissolved in water, and the reaction is carried out under protective atmosphere, dialysis, to obtain nanogel dispersion;The nanogel dispersion is mixed with the nanometer zinc oxide dispersion to obtain a nanogel composite zinc oxide antibacterial coating, and a coating is formed after coating.The nanometer composite antibacterial coating for dental material has excellent retention capacity and antibacterial performance.

This invention relates to a method for preparing a nanozyme detection reagent for carbofuran residues in apples, belonging to the field of pesticide residue and food safety technology. Specific steps: (1) Prepare mesoporous polydopamine powder using polyoxyethylene-polyoxypropylene-polyoxyethylene triblock copolymer, dopamine hydrochloride, etc.; (2) Prepare a copper-manganese bimetallic carbon dot solution using citric acid, copper chloride, manganese chloride, and ethylenediamine; (3) Prepare the nanozyme detection reagent using the mesoporous polydopamine solution and the copper-manganese bimetallic carbon dot solution. Mesoporous polydopamine has a large specific surface area, providing numerous sites for carbon dot loading and effectively adsorbing carbofuran molecules. The copper-manganese bimetallic carbon dots give the nanozyme detection reagent good enzyme-like activity and generate pesticide concentration-dependent colorimetric and photothermal signals. This invention achieves mutual verification of dual-mode output signals, significantly improving detection reliability; and completes detection within 1.5 h.

The application discloses a continuous production process and equipment for a trifluoromethylbenzene tower, and belongs to the field of organic fluorine chemistry. The production process comprises the following steps: S1: continuously feeding trichloromethylbenzene and hydrogen fluoride into a tower reactor connected with a heat exchanger circulating cooling system in a reverse direction, so that a three-stage continuous fluorination reaction occurs in the tower reactor to obtain crude trifluoromethylbenzene, and unreacted hydrogen fluoride is separated into liquid at the top of the tower and then flows back into the tower reactor; S2: the crude trifluoromethylbenzene obtained in the reaction is subjected to nitrogen bubbling in a bubble tower, and then is continuously distilled in a rectifying tower to obtain finished trifluoromethylbenzene; and S3: byproduct hydrogen chloride generated in the fluorination reaction is introduced into a hydrochloric acid tank to obtain hydrochloric acid, and the content of hydrofluoric acid in the hydrochloric acid is less than 1000 ppm. The method can greatly improve the utilization rate of raw material hydrogen fluoride, improve the purity of byproduct hydrochloric acid, reduce the generation amount of waste acid, avoid the sharp change of pressure in the reaction process, and realize large-scale, continuous, stable and safe production of trifluoromethylbenzene.

This invention relates to crystals of compounds of formula (I), their preparation methods, and applications. Specifically, this invention provides crystals of compounds of formula (I), wherein the crystal form is selected from the group consisting of crystal form A, crystal form B, crystal form C, and crystal form D, wherein n = 1 to 2. The crystal forms exhibit good stability, high purity, excellent physicochemical properties, and simple preparation processes.

The application discloses a preparation method of low host DNA in human adenovirus preparation and relates to the technical field of gene therapy preparation. The preparation method is as follows: a pretreatment agent is added into an adenovirus-containing solution for pretreatment, and then microjet treatment is performed; per liter of the adenovirus-containing solution comprises the following concentrations of the pretreatment agent: 18-30 g / L of sodium chloride, 2-5 g / L of arginine hydrochloride, 0.1-1 mL / L of non-ionic surfactant and 5-10 g / L of potassium chloride, and a PBS buffer is used to stabilize pH; the microjet treatment adopts a Y-shaped channel structure, the channel aperture is 25-100 mu m, and the pressure of the microjet treatment is 2000-3000 bar. The combination of the pretreatment and the microjet treatment achieves the technical effects of efficient removal of host DNA and efficient recovery of viruses.

The present invention relates to a preparation method for a high-purity Jaktinib dihydrochloride monohydrate compound represented by formula (A). The whole process does not comprise special reaction conditions and complex post-treatment processes, and is easily available in raw materials and reagents, high in conversion rate, environment-friendly, and very suitable for industrial production.

This invention relates to the field of hand hygiene cleaning and disinfection technology. An embodiment of this invention discloses a rinse-free disinfectant and its preparation method. The rinse-free disinfectant comprises octinidin hydrochloride, ethanol, and a solvent. The mass percentage of octinidin hydrochloride in the rinse-free disinfectant is 0.1%-0.3%, and the mass percentage of ethanol in the rinse-free disinfectant is 50-60%. After use, it can effectively kill Gram-negative bacilli and Gram-positive bacteria on the hands, exhibiting significant disinfection and sterilization effects, as well as long-lasting antibacterial effects, with mild efficacy and stable performance.

The application belongs to the technical field of antitumor drugs, and particularly relates to an AuNRs@L / D-Ag2S QDs complex, a preparation method and application thereof. Sodium polystyrene sulfonate is electrostatically adsorbed on AuNRs to obtain 1-PSS-AuNRs; polyallylamine hydrochloride is electrostatically adsorbed on 1-PSS-AuNRs to obtain 2-PAH-AuNRs; polyallylamine hydrochloride is electrostatically adsorbed on 2-PAH-AuNRs to obtain a non-chiral nanomaterial; and the non-chiral nanomaterial is covalently crosslinked with L / D-Ag2S QDs to obtain the AuNRs@L / D-Ag2S QDs complex. The application combines the efficient photo-thermal conversion characteristics of AuNRs with the chiral-dependent targeting and potential fluorescence imaging ability of chiral Ag2S quantum dots by constructing a complex structure, so that a novel nanodiagnostic and therapeutic agent with efficient photo-thermal performance and chiral selectivity is obtained.

The present disclosure discloses a lurasidone hydrochloride oral film composition, preparation method and use thereof. The present disclosure discloses the lurasidone hydrochloride oral film composition including an active pharmaceutical, a film-forming material, a plasticizer and a flavoring agent, wherein the active pharmaceutical is (3aR,4S,7R,7aS)-2-((1R,2R)-2-[4-(1.2-benzisothiazol3-yl)piperazine-1-methyl]cyclohexylmethyl)hexahydro-4.7-methylene-2H-isoindole-1,3-dione hydrochloride denoted by the following formula I. The lurasidone hydrochloride oral film composition of the present disclosure has a good dissolution rate, a uniform appearance, a good flexibility, and a uniformity content meeting the requirement. Moreover, during the preparation process of the film liquid of the composition, sedimentation of the film will not occur. After the composition is dissolved in the user’s mouth, the user does not have any gritty feeling.

This invention discloses a method for preparing a carbon nanotube-modified copper-based MOF electrode material and its application, comprising: 1) dissolving a Cu2+ precursor and BTA hydrochloride separately in water to obtain two solutions; 2) slowly adding the copper-containing solution obtained in step 1) to the BTA hydrochloride solution and mixing, then adding concentrated ammonia to the mixed solution; 3) adding carbon nanotubes to the final solution obtained in step 2) and stirring; the amount of carbon nanotubes is 0.42 mmol to 1.2 mmol; 4) subjecting the solution obtained in step 3) to a hydrothermal reaction at a set time and temperature, washing the solid precipitated in the solution and drying it under a specific environment to obtain the carbon nanotube-modified copper-based MOF electrode material. This invention increases the conductivity and reactivity of the battery by adding carbon nanotubes to the copper-based MOF electrode. Through nanostructuring and compositing of the material, the interlayer spacing is also improved, thereby enhancing the cycle stability of the reaction.

This invention discloses a hair repair composition for permed hair, comprising, by weight: 0.02-1.0 parts hydrolyzed plant protein, 0.1-2.0 parts biomimetic amino acid complex, 50-95 parts carrier, and 0.5-15 parts additives. The hydrolyzed plant protein is obtained from Moringa seed protein through multi-enzyme synergistic hydrolysis, with a molecular weight less than 3500 Daltons. The biomimetic amino acid complex includes at least wheat amino acids, soybean amino acids, arginine hydrochloride, serine, and threonine. Under weakly acidic conditions, this composition can simultaneously repair broken disulfide bonds, hydrogen bonds, and ionic bonds in hair. The hydrolyzed plant protein provides disulfide bond reconnection sites, and the biomimetic amino acid complex constructs a multi-point weak bond network through hydroxyl and ionic groups, achieving "triple bond repair" synergistically. This invention can significantly improve the mechanical strength, elasticity, and breakage resistance of damaged hair, with long-lasting, gentle, and safe repair effects, suitable for daily care of damaged hair after perming and dyeing.

The application relates to a synthesis method of a positive electric three-component covalent organic polymer and application thereof, and belongs to the technical field of sewage treatment. The method is as follows: 1,3,5-benzene triformylhydrazine is dissolved in an organic solvent dimethyl sulfoxide to obtain a solution A; 1,3-diamino guanidine hydrochloride is dissolved in the solution A to obtain a solution B; 2,3,5,6-tetrafluoro-p-xylene dicarboxaldehyde is dissolved in the solution B to obtain a solution C, and the preparation of the solutions is carried out in a constant-temperature oil bath; then, the orange wet gel is obtained by heating at 100 DEG C for 30s; the orange wet gel is placed in a dialysis bag for dialysis, the mixture is taken out for freezing, and then the freezing drying is carried out under vacuum to obtain the positive electric three-component covalent organic polymer. The synthesis method is simple, high in yield and fast in speed, the specific surface area of the positive electric three-component covalent organic polymer is large, the positive electric three-component covalent organic polymer has a hierarchical porous structure and rich reaction active sites, and can be used as a high-efficiency adsorbent to remove perfluorooctanoic acid in water.

The present invention provides micronized solid crystalline forms of a hydrochloride salt of a specific antiviral helicase-eliciting enzyme inhibitor compound according to Formula (I), compositions thereof, methods for their production, and methods of using the micronized solid crystalline forms in the treatment or prevention of herpes simplex infection and herpes simplex mediated diseases.

This invention discloses a highly selective method for preparing triethylenetetramine. The method uses 2-chloroethylamine hydrochloride and ethylenediamine as raw materials, reacting them in an aqueous solution. An aqueous solution of ethylenediamine with a concentration of 1-100 wt% is added dropwise to an aqueous solution of 2-chloroethylamine hydrochloride with a concentration of 1-100 wt%. The dropping rate of the ethylenediamine solution is 5% to 100% of its own mass per hour. The reaction temperature is 30-200 °C (oil bath temperature), and the reaction time is 2-20 hours (including the dropping time). The molar ratio of 2-chloroethylamine hydrochloride to ethylenediamine is 2:1 to 40:1. This invention is the first to propose a direct synthesis of triethylenetetramine from the bulk chemicals 2-chloroethylamine hydrochloride and ethylenediamine. Compared with the previously reported dichloroethane amination method and the nucleophilic substitution method between dichloroethane and ethylenediamine, this method offers milder reaction conditions, simpler operation, and higher selectivity, making it suitable for industrial production.

The present invention relates to Givinostat hydrochloride monohydrate for use in the treatment of arrhythmogenic cardiomyopathy.

This invention provides a process for extracting biliverdin hydrochloride through bio-fermentation and a method for synthesizing bilirubin. By studying the complex system of biliverdin obtained through microbial bacterial fermentation, a process for separating and purifying biliverdin was established, and the obtained biliverdin was further used to synthesize bilirubin. This process is simple to operate, uses common resins, employs solvents with low toxicity that are easily recovered and reused, utilizes low-energy membrane separation equipment for concentration, and uses conventional reaction reagents as reducing agents. The process has low operating costs, is environmentally friendly, and yields high-purity and stable-yield biliverdin and bilirubin products, demonstrating excellent prospects for industrial application.

The application belongs to the technical field of diamine and polyamine of diphenylmethane series, and particularly relates to a preparation method of diamine and polyamine (DAM) of diphenylmethane series, that is, before a condensation reaction, a mixing characteristic parameter 1.0<=M<=1.5 of a pre-reaction liquid for the condensation reaction is controlled; the pre-reaction liquid is a mixed liquid formed after a mixture of a formaldehyde solution and aniline hydrochloride or a mixture of the formaldehyde solution and aniline hydrochloride / condensation reaction liquid is pre-mixed. In the method, the mixing characteristic parameter M is controlled in a suitable range, so that the content of N-methyl impurities and the content of macromolecular polymers in the DAM product can be maximally reduced, and the running stability of a production device and the quality of downstream products can be improved.

This invention discloses a method for synthesizing p-methylaminobenzoylglutamate diethyl ester. Using p-methylaminobenzoic acid and diethyl glutamate hydrochloride as raw materials, and carbonyl diimidazole as an ester activator, the specific synthesis method involves dissolving carbonyl diimidazole in a solvent under inert gas protection, stirring, adding p-methylaminobenzoic acid to generate the active ester, then adding diethyl glutamate hydrochloride and reacting. The mixture is then concentrated, cooled, water is added dropwise, filtered, and dried to obtain p-methylaminobenzoylglutamate diethyl ester. This method is simple, convenient, low-cost, and has a high yield, showing great promise for industrialization.

This invention is entitled "A Method for Preparing an Intermediate of Aericoxib," belonging to the field of pharmaceutical preparation technology. The technical problem to be solved is to provide a method for preparing an intermediate of Aericoxib that is simple to operate, uses readily available raw materials, and has simple post-processing. The key points of the technical solution are that the preparation method includes the following steps: (1) 2-bromo-1-(4-methanesulfonyl)acetophenone, hexamethylenetetramine and solvent are reacted, filtered, hydrochloric acid and methanol are added, and the reaction is continued to obtain 2-amino-1-(4-methanesulfonyl)acetophenone hydrochloride; (2) 2-amino-1-(4-methanesulfonyl)acetophenone hydrochloride, p-methylphenylacetic acid, base 1 and solvent are mixed, reacted, cooled to -5℃-15℃, base 2 and 1-bromopropane are added, and the reaction is continued to obtain the intermediate.

This invention provides a highly adhesive, wide-temperature-range aqueous hydrogel electrolyte for zinc-ion batteries, its preparation method, and its applications. The method includes the following steps: dissolving sodium alginate in 2-morpholine ethanesulfonic acid buffer solution, adding EDC and NHS, and activating; then adding dopamine hydrochloride, undergoing an amidation reaction, dialysis purification, and freeze-drying to obtain SA-DA powder; adding gelatin and SA-DA powder to deionized water, stirring and mixing evenly, and allowing to stand; then immersing in the electrolyte and undergoing soaking treatment to obtain the final product. The electrolyte of this invention exhibits excellent interfacial adhesion and flexible mechanical properties, significantly improved electrochemical stability and cycle life, excellent wide-temperature-range adaptability and anti-drying ability, outstanding safety and biocompatibility, and a simple and highly controllable process, providing key technical support for the development of high-performance, high-safety flexible aqueous zinc-ion batteries.

The application discloses a kind of purification process of L-lysine, comprising the following steps: prepared L-lysine hydrochloride solution is passed through resin column, and is automatically collected, and L-lysine collection solution is obtained, after filtration, concentration, spray drying, vacuum drying, L-lysine finished product is obtained;Wherein, the mode of automatic collection is as follows: when the conductivity value is in ≥100us / cm, effluent is collected, when the conductivity drops to ≤100us / cm, collection is ended.The method overcomes the above-mentioned method and timeliness, equipment requirement is high, and the drawbacks such as labor intensity is big, ensure the timeliness and accuracy of process monitoring, and realize automatic control, and ensure that L-lysine yield and purity are higher.

The application belongs to the technical field of extraction separation, and particularly relates to a 3N-PTD ligand and a preparation method and application thereof. The preparation method provided by the application comprises the following steps: mixing 3-chloropropylamine hydrochloride, sodium azide and deionized water, and performing a reflux reaction to obtain 3-azidopropylamine; dissolving 2,6-diethynylpyridine, 3-azidopropylamine, sodium ascorbate and CuSO4.5H2O, and performing a click reaction to obtain the 3N-PTD ligand. The yield of the 3N-PTD ligand obtained by the preparation method is high.

This invention discloses a method for preparing raloxifene EP impurity B, comprising the following steps: dissolving 6-methoxy-2-(4-methoxyphenyl)benzothiophene (Ⅰ) as a raw material in solvent one, adding NIS, and then adding a free radical initiator to react and obtain intermediate III; dissolving 4-[2-(1-pyrrolidinyl)ethoxy]benzoate salt (II) in solvent two, adding solvent two or not, and then adding a chlorinating agent to react and generate intermediate IV; dissolving intermediate III in solvent three, adding a Lewis acid, and then adding intermediate IV, and performing a Friedel-Crafts acylation reaction to generate intermediate V; dissolving intermediate V in solvent four, adding a demethylating agent, and generating bisphenol hydroxyl intermediate VI under demethylation conditions; dissolving intermediate VI in solvent five, adding a reducing agent, and generating intermediate VII through a reduction reaction; dissolving intermediate VII in formic acid, stirring, evaporating, and finally lyophilizing to generate the formate target product VIII.

The application discloses a norpinane alkyl carbazole enhanced fluorescent probe for detecting viscosity and a preparation method and application thereof. The application takes norpinone as raw material, and performs a cyclization reaction with phenylhydrazine hydrochloride to obtain a compound TC; the compound TC is subjected to N-alkylation reaction with N,N-dimethyl-3-chloropropylamine to obtain a compound TC-AP; the compound TC-AP is subjected to formylation reaction with phosphorus oxychloride to obtain a compound TC-AP-F; and the compound TC-AP-F is subjected to condensation reaction with 4-(cyanomethyl)-1-methylpyridin-1-yl iodide to obtain a fluorescent probe TC-AP-A. The probe TC-AP-A can specifically recognize viscosity, and the red fluorescence of the solution is gradually enhanced with the continuous increase of the viscosity of the system, and the minimum detection limit is 1.41 cP. The probe has the advantages of simple synthesis, good selectivity, high sensitivity, good biocompatibility, low toxicity and the like, and has a good application prospect.

This invention discloses a vascular bundle-targeted bio-selenium nanoparticle, its preparation method, and its application, belonging to the field of plant treatment technology. The invention involves mixing and dissolving bio-selenium nanoparticles, water, 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride, and N-hydroxysuccinimide, followed by activation to obtain an activated bio-selenium nanoparticle solution. A xylem-anchored peptide and MES buffer are then mixed and dissolved to obtain a xylem-anchored peptide solution. The activated bio-selenium nanoparticle solution and the xylem-anchored peptide solution are mixed, and the pH is adjusted to 6.3-6.8 before stirring to obtain the vascular bundle-targeted bio-selenium nanoparticle. The vascular bundle-targeted bio-selenium nanoparticle provided by this invention achieves interception of heavy metal transport pathways by specifically anchoring to xylem vessels. Compared with existing technologies that rely solely on broad-spectrum physiological antagonism, its efficiency in reducing heavy metal content in crop stems and leaves represents a qualitative leap.

This invention discloses a method for synthesizing a tenapano hydrochloride intermediate. The synthesis method includes the following steps: (1) condensing the compound 3-bromophenylacetaldehyde and the compound N-methyl-(2,4-dichlorophenyl)methylamine under dehydration conditions to obtain an enamine intermediate; (2) subjecting the enamine intermediate to an intramolecular cyclization reaction in the presence of an acid catalyst to obtain the tenapano hydrochloride intermediate 4-(3-bromophenyl)-6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinoline. The synthetic route provided by this invention requires only two steps to construct the key framework, and has the advantages of short reaction steps, high overall yield, and no need to use highly toxic liquid bromine. This process has high atom economy, reduces the emission of waste gas, wastewater, and solid waste, and is suitable for large-scale industrial production under mild conditions.

The invention relates to certain chromanol, quinone or hydroquinone compounds and derivatives thereof for treatment of Alzheimer's disease and / or for improving memory function and / or reducing plaque load. Specifically, the present invention relates to chromanol compounds chosen from (6-hydroxy-2,5,7,8-tetramethylchroman-2yl)(piperazin-1-5 yl)methanone, ((S)-6-hydroxy-2,5,7,8-tetramethyl-N-((R)-piperidin-3-yl)chroman-2- carboxamide hydrochloride and S-(6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)(4-(2- hydroxyethyl)piperazin-1-yl)methanone, and pharmaceutically acceptable salts thereof.

The invention relates to the technical field of tin alloy solder, and discloses a preformed soldering lug with high welding strength, which comprises a soldering flux layer and a soldering lug main body, the soldering flux layer comprises esterified rosin, methyl ester, succinic acid, glutaric acid, cyclohexylamine hydrochloride and isopropanol; the soldering lug main body comprises tin, antimony, silver, bismuth, copper and nickel; by adding silver, bismuth, copper, nickel and metal elements in the alloy into the soldering lug, the mechanical strength of the solder alloy can be improved, compared with common tin-copper alloy, the mechanical strength of the soldering lug is greatly improved, the soldering flux is high in activity but low in corrosivity, stable high-mechanical-strength intermediate layer alloy is formed, and the soldering flux can be applied to the field of soldering. The welding strength and the tensile strength are more excellent, the soldering flux layer and the soldering lug main body have the synergistic effect, so that a welded part has high tensile property after being welded, and the mechanical strength of the solder alloy can be improved by adding silver, bismuth, copper and nickel in the alloy into the soldering lug and metal elements.