11869 results about "Hydrochloride" patented technology

The purinone derivative 6-amino-9-[(3R)-1-(2-butynoyl)-3-pyrrolidinyl]-7-(4-phenoxyphenyl)-7,9-dihydro-8H-purin-8-one hydrochloride has Btk-selective inhibitory activity and, in addition to having excellent metabolic stability, it is a compound that exhibits a high level of solubility and absorption with respect to the free base and can be crystallized, hence it can serve as a therapeutic agent for diseases involving B cells and mast cells.

A composition comprising a collagen protein and demineralized bone matrix is described wherein the composition is chemically cross-linked with a carbodiimide such as N-(3-dimethylaminopropyl)-N-ethylcarbodiimide hydrochloride (EDC). The crosslinking reaction can be conducted in the presence of N-hydroxysuccinimide (NHS). The collagen can be in a porous matrix or scaffolding. The DBM can be in the form of particles dispersed in the collagen. A method of making the composition is also described wherein a collagen slurry is cast into the desired shape, freeze dried to form a porous scaffolding and infitrated with a solution comprising the cross-linking agent. The composition can be used as an implant for tissue (e.g., soft tissue or bone) engineering.

The present invention provides methods for transdermal delivery of a therapeutically effective amount of Naltrexone Hydrochloride, Naltrexol Hydrochloride, and / or Naltrexone Diol Ester using microneedles. The invention also provides methods for treatment of narcotic dependence, alcohol abuse, and / or alcoholism. Preferably, the Naltrexone Hydrochloride, Naltrexol Hydrochloride, and / or Naltrexone Diol Ester is administered by creating a microneedle-treated site in the skin of a subject by inserting microneedles, followed by applying the Naltrexone Hydrochloride, Naltrexol Hydrochloride, and / or Naltrexone Diol Ester to the microneedle-treated site.

The present invention relates to a process for the preparation of chiral 4-hydroxy-2-oxo-1-pyrrolidine acetamide. The process comprises adding sodium cyanide together with citric acid to a solution of chiral epichlorohydrin to obtain chiral 3-chloro-2-hydroxypropionitrile by ring opening reaction of the chiral epichlorohydrin, reacting the obtained product with an alcohol containing hydrochloride gas to obtain chiral 4-chloro-3-hydroxybutyric acid ester, and reacting the obtained product in a presence of a base with glycinamide or with glycine ester accompanied by ammonolysis with ammonia to produce the targeted chiral 4-hydroxy-2-oxo-1-pyrrolidine acetamide. The process according to the present invention provides optically pure 4-hydroxy-2-oxo-1-pyrrolidine acetamide in high yield and in high purity, which is suitable for industrial mass-production.

The invention discloses a super-hydrophobic and super-oleophylic oil-water separating mesh membrane and a preparation method thereof. The method comprises the following steps of: (1), cleaning a fabric mesh and drying the cleaned fabric mesh; (2), dissolving dopamine hydrochloride and trihytdroxy methyl-aminomethane to water to acquire a mixed solution, wherein the pH value of the mixed solution is 8.0-12.0; (3), soaking the dried fabric mesh in the mixed solution, and then getting out the soaked fabric mesh for drying; (4), dissolving mercaptan compound and sodium hydroxide in water to acquire mixed turbid liquid; (5), soaking the fabric mesh acquired in the step (3) in the mixed turbid liquid, reacting the mixture to acquire the oil-water separating mesh membrane. The oil-water separating mesh membrane disclosed by the invention has high bearing pressure to water so that oil can quickly pass, a separating effect is good, the speed is high, and the separating effect on normal hexane, petroleum ether, benzene, gasoline, diesel oil, animal and vegetable oil, crude oil and the like is good. The oil-water separating mesh membrane is non-toxic and harmless, environment-friendly, easy to clean and keep, can be reusable, and has good stability.

A cleaning and biocidal composition in liquid form comprising a solvent, a polymeric biguanide, a single quaternary ammonium salt, a sequestrant, and at least one surfactant. The composition comprising the solvent including water, the polymeric biguanide including a polyhexamethylene biguanide hydrochloride, the quaternary ammonium salt including a didecyldimethyl ammonium chloride, the sequestrant including an amino acid chelating agent selected from the group consisting of: ethylenediaminetetraacetic acid, nitrilotriacetic acid, tetrasodium ethylenediaminetetraacetic acid, or mixtures thereof, the surfactant including a non-ionic surfactant and an amphoteric surfactant.

The present invention relates to a pharmaceutical composition comprising a solid suspension prepared by hot melt extrusion of isobutyric acid (2R,3S,4R,5R)-5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-2-azido-3,4-bis-iso-butyryloxy-tetrahydro-furan-2-ylmethyl ester; hydrochloride salt (I) and a polyethylene glycol (PEG) / polypropylene glycol (PPG) block copolymer.

The invention discloses poly dopamine-modified reduced graphene oxide and a preparation method and application thereof, the polydopamine-modified reduced graphene oxide includes reduced graphene oxide and poly dopamine, and the poly dopamine is attached to the surface of the reduced graphene oxide in physical adsorption manner. The preparation method comprises the following steps: according to the mass ratio of (1-4): (1-4), weighing graphene oxide and dopamine hydrochloride, adding the graphene oxide and the dopamine hydrochloride into solvent to completely dissolve to prepare a mixed solution; adjusting the pH value of the mixed solution to 8.5-9, and reacting for 12h-24h at the temperature of 55 to 65 DEG C to obtain the poly dopamine-modified reduced graphene oxide. The preparation method is friendly to the environment, low in reduction temperature, in no need of adding a stabilizer, and simple in process, realizes the reduction and stabilization in one step, and is suitable for mass production. The invention also provides the application of the poly dopamine-modified reduced graphene oxide.

The synthesis process of phenyl dimethylene diisocyanate belongs to the field of isocyanate synthesizing technology. In inert liquid medium, phenyl dimethylamine or its hydrochloride or carbonate reacts with bis(trichloromethyl) carbonate at the temperature of -20 deg.c to -60 deg.c, before heating and reflux reaction for 0.5-5 hr to synthesize phenyl dimethylene diisocyanate. The amount of bis(trichloromethyl) carbonate is 0.5-15 times that of phenyl dimethylamine or its hydrochloride or carbonate. The present invention has stable solid crystal materials, and is environment friendly and suitable for industrial production.

A process for preparing an asymmetrical indocyanine dye comprising the steps of:a) reacting a first quaternised indolenine or substituted indolenine with a compound of the formula (II)or hydrochloride thereof, wherein n is 0 or 1 Ph is phenyl or substituted phenyl X is hydrogen, halogen or alkyl, preferably chlorine, in a solvent selected from the group consisting of acetic acid, acetic anhydride and mixtures thereof in the presence of acetyl chloride, to obtain an intermediate hemicyanine, andb) further reacting said intermediate hemicyanine with a second quaternised indolenine or substituted indolenine different from said first indolenine.

An object of the present invention is to provide a process capable of producing a self-assembling peptide derivative that is useful in the fields of regenerative medicine and surgery in large quantities and in an economical and efficient manner. In particular, provided is a production process employing a combination of (i) a step of convergently constructing a sequence with use of a common repeating unit consisting of a specific amino acid sequence and (ii) a step of first isolating the peptide derivative as a disulfuric acid salt, a tetramethanesulfonic acid salt or a tetra(trifluoroacetic acid (TFA) salt), and then subjecting the peptide salt to a salt exchange reaction to yield a tetrahydrochloric acid salt.

A crystalline form of epirubicin hydrochloride, named herein as “type II” crystalline epirubicin hydrochloride, has excellent thermal stability. Type II crystalline epirubicin hydrochloride has a powder X-ray diffraction pattern having average values of diffraction angle (2θ) and relative intensity P(%) as presented in the following table:DiffractionAngleRelative Intensity2ΘP (%)5.2369.89.21212.513.73215.516.4464.818.234521.1149.722.52925.524.07129.925.87918.427.76216.529.75710.134.3924.438.15713.144.2935.964.6997.777.815100.

The invention discloses a polysaccharide-dopamine composite biogel and application of the biogel. A preparation method of the biogel comprises the following steps: dissolving 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and N-hydroxy succinimide sodium in an MES (Methyl Ester Sulfonate) buffer solution with a pH value being 5-6 in an inert gas atmosphere so as to prepare an EDC (ethylcarbodiimide) mixed solution, subsequently adding the EDC mixed solution into a polysaccharide solution for reacting at 20-30 DEG C for 0.5-1 hour, then adding a dopamine solution for further reacting at 20-30 DEG C for 1-4 hours, dialyzing a reactant by taking distilled water as a dialyzate, taking trapped fluid for freezing and drying to obtain the polysaccharide-dopamine composite biogel. The polysaccharide-dopamine composite biogel is simple and effective in modification method and capable of increasing the surface viscidity of the cartilage tissue, reducing loss of therapeutic drugs or implanted cells and facilitating the repairing of the cartilage injury.

A combination of one or more HMG-CoA reductase inhibitors (for example pravastatin, lovastatin, simvastatin, fluvastatin, rivastatin or atorvastatin) with one or more insulin sensitizers (for example troglitazone, pioglitazone, englitazone, BRL-49653, 5-(4-{2-[1-(4-2'-pyridylphenyl)ethylideneaminooxy]ethoxy}benzyl)thiazolidine-2,4-dione, 5-{4-(5-methoxy-3-methylimidazo[5,4-b]pyridin-2-ylmethoxy)benzyl}thiazolidine-2,4-dione or its hydrochloride, 5-[4-(6-methoxy-1-methylbenzimidazol-2-ylmethoxy)benzyl]thiazolidine-2,4-dione, 5-[4-(1-methylbenzimidazol-2-ylmethoxy)benzyl]thiazolidine-2,4-dione and 5-[4-(5-hydroxy-1,4,6,7-tetramethylbenzimidazol-2-ylmethoxy)benzyl]thiazolidine-2,4-dione) exhibits a synergistic effect and is significantly better at preventing and / or treating arteriosclerosis and / or xanthoma than is either of the components of the combination alone.

The invention discloses a titanium alloy containing an antibacterial coating as well as a preparation method and application thereof. The titanium alloy deposited with nano-silver antibacterial coating on the surface is prepared by the following steps: preprocessing and sterilizing the surface of titanium alloy; then soaking the titanium alloy in a dopamine hydrochloride solution with mass-volume concentration of 1-10mg / mL for 12-36h to obtain titanium alloy deposited with a polydopamine thin film layer on the surface; and finally soaking the titanium alloy in a silver nitrate solution which is 5-100mmol / L in concentration for 12-36h. According to the titanium alloy disclosed by the invention, the titanium alloy is connected to silver nanoparticles by virtue of adhesion from self-polymerization of dopamine and adsorbed silver ions are reduced into nano-silver in situ through weak reducibility of the dopamine. Because of broad-spectrum antibacterial capacity of the nano-silver, an excellent antibacterial effect can be achieved with relatively low effect concentration. The invention provides new thinking for antibacterial modification of the titanium alloy, and can effectively promote application of a titanium alloy implant material in the fields of bone tissue repair and regeneration.

The invention is an active ingredient combination comprising polyhexamethylenebiguanidine hydrochloride and distearyldimethylammonium chloride and a cosmetic or dermatological formulation comprising polyhexamethylenebiguanidine hydrochloride and distearyldimethylammonium chloride. The invention also includes methods of fighting or preventing dermatological harm comprising applying to the skin a cosmetic or dermatological formulation comprising polyhexamethylene biguanidine hydrochloride and distearyldimethylammonium chloride. The invention also includes methods of preventing decay of organic substances in a formulation, comprising adding to said formulation polyhexamethylene biguanidine hydrochloride and distearyidimethylammonium chloride.

The invention is drawn to novel gold nanoparticles that are used in a dual optical method for sensitive and selective detection of antigens. The gold nanoparticle aggregates are synthesized from gold hydrochloride and sulfur salts in an aqueous solution. The aggregates can be selectively sized using a spectral notch filter that results in an improved product with versatile uses. The gold nanoparticles can also be used in improved optical communications devices.

The invention provides a low protein ration premix compound for growing pigs and a using method thereof. The low protein ration premix compound consists of mountain flour, calcium hydrophosphate, salt, sodium bicarbonate, L-lysine hydrochloride, DL-methionine, L-threonine hydrochloride, L-tryptophan hydrochloride, an antioxidant and the like. The crude protein content of the prepared growing and fattening pig ration is respectively reduced from 16.4 percent to 14.5 percent and from 15.4 percent to 12.5 percent. The invention aims to add commodity amino acid to produce the low protein ration premix compound to enlarge the applicability of the low protein ration technology and improves the conversion efficiency of the ration, reduces the use of the protein raw materials, reduces the feeding cost and reduces discharge by reducing the concentration of the crude protein of the prepared ration.

The nitrobacteria culture promoter consists of molasses 100 weight portions, ferrous salt 0.2-2.5 weight portions and adsorbent 1-8 weight portions. The ferrous salt includes is sulfate or hydrochloride. The adsorbent is zeolite powder, diatomite, powdered active carbon, fly ash or their mixture. The nitrobacteria culture promoter is used in biological nitrification process of eliminating ammonia nitrogen and thrown into sewage directly to promote the propagation and growth of nitrobacteria in sewage. Through combination with sewage temperature regulation, dissolving oxygen, regulating pH, etc, the nitrification may be completed in short period. It has raised ammonia nitrogen eliminating rate and low cost.

The invention relates to a dibenzoxazine containing an oxazole ring and a preparation method thereof. The preparation method comprises the following two steps of: 1: mixing ortho-aminophenol hydrochloride and para-hydroxybenzoic acid, adding polyphosphoric acid as a solvent, reacting at 60-180 DEG C for 24-60 hours, and washing by using deionized water, filtering and drying to obtain diphenol containing an oxazole ring structure; and 2: mixing the diphenol containing the oxazole ring structure, phenylamine and paraformaldehyde, reacting at 80-110 DEG C for 40-80 minutes, then filtering and precipitating, washing 4-8 times by using alkali liquor, and then washing, filtering and drying to obtain the product. The dibenzoxazine disclosed by the invention has the advantages of very good mechanical property because the high temperature resistant oxazole ring structure is introduced to a benzoxazine molecule structure, dielectric constant of only 1.6-2.3, simple process, lower equipment requirement and suitability for large-scale production.

The invention relates to a method for pretreating fibers, comprising the following steps of: performing surface activation on fibers by a dopamine hydrochloride biomimetic modification method, and then performing impregnation treatment on the fibers by using impregnation solution composed of rubber latex and phenolic resin, aiming to improve the interface adhesion property of the fibers with rubber so that the fibers are more suitable for tyres, conveyor belts, high-pressure rubber tubes and transmission belts. The method solves the experimental problem caused by high toxicity of isocyanate and avoids damage on the fibers caused by high-temperature treatment; and the process flow is simplified and the production cost is reduced.

The invention relates to crosslinked acid sand fracturing acid liquor, comprising the following components in percentage by weight: 0.7% of thickening agent, 1.5% of cross-linking agent, 1.5% of corrosion inhibitor, 0.5% of surfactant, 0.15% of stabilizing agent, 20% of hydrochloric acid and 75.65% of water, wherein the thickening agent consists of the following components by weight percent: 6.61% of methacrylamidoethyltrimethylamine hydrochloride, 3.22% of acrylamide, 1.25% of acrylic acid, 9.52% of 2-acrylamide-2-methylpropanesulfonic acid, 6.15% of sodium hydroxide and 73.25% of deionized water; and the cross-linking agent consists of the following components in percentage by weight: 1% of zirconium oxychloride, 80% of formaldehyde and 19% of glyoxal. The crosslinked acid sand fracturing acid liquor can be cross-linked in 20% hydrochloric acid, the temperature resistance reaches 100 DEG C, the constant of reaction rate of acid-rock is 1.3744*10-6 (mol / cm<3>)(1-m)*(cm / s), and the viscosity of the gel-breaking liquid is less than 10 mPa.s.

The invention relates to a method for preparing an uramine-type macromolecule anti-bacterial agent, comprising two steps as follows: A, mixing any one solution of guanidine hcl, Polyhexamethyleneguanidine chloride and polyhexamethylene biguanide hydrochloride with maleic anhydride solution; introducing nitrogen for constant-temperature water bath reaction to obtain functional uramine salt; B, mixing functional uramine salt solution with acrylamide and / or styrene for constant-temperature water bath reaction to obtain ivory-white stringy liquid; depositing soft white solid with solvent for vacuum drying to obtain ivory-white bulk uramine-type copolymer, i.e, uramine-type macromolecule anti-bacterial agent. The uramine-type macromolecule anti-bacterial agent has remarkable effect and simple synthesis process, ensures that the anti-bacterial group is hard to move and the processing thermal stability is excellent through copolymerization on macromolecule long chain. The invention can be widely used in fields of plastic, dope, powder dope, rubber, wood plastic, rubber plastic, spinning, water processing, and the like.

The invention discloses a nitrogen-doped carbon-clad manganese oxide lithium ion battery composite cathode material, and a preparation method and an application of the composite cathode material. The composite material is composited by nanoscale manganese oxide and dopamine, wherein manganese oxide is spherical. The method comprises the steps of mixing a prepared spherical manganese oxide nano particle and dopamine hydrochloride, performing filtering, washing and drying to obtain a manganese oxide and polydopamine composite, and then converting a polymerization layer into a nitrogen-doped carbon layer by high-temperature carbonization. The prepared nitrogen-doped carbon-clad manganese oxide (MnO@NC) lithium ion battery composite cathode material is stable in structure and good in conductivity, and has excellent rate capability and cycling stability as a lithium ion battery cathode material; and polymerization of the dopamine is only completed at a room temperature and under a slightly alkaline condition, so that the composite cathode material is low in cost, low in energy consumption, convenient to control and environment-friendly, is suitable for a practical application of a lithium ion battery, and can realize industrial mass production.

The invention relates to hydrochloric acid exhausted liquid reclaiming process. It includes the following steps: water operation after 390 centigrade degree; adding 18-20 percent hydrochloric acid before acid operation 5-10 minutes; acid operation; and blowing out. It can reduce brown iron oxide density of discharging gas, and the iron content in reclaimed acid.

The invention discloses a synthesis method of a metal organic framework composite material which has a sandwich structure, comprises magnetic microsphere ferroferric oxide surface coating polydopamine and takes zirconium ion as central metal ion and application of the material. The synthesis method comprises the following steps: firstly synthesizing ferroferric oxide magnetic microspheres by using a hydrothermal synthesis method; dispersing the magnetic microspheres in an aqueous solution of polydopamine hydrochloride to coat the surfaces of the magnetic microspheres with polydopamine layers; dispersing the magnetic microspheres coated with the polydopamine in an N,N-dimethylformamide mixed solution of zirconium chloride and terephthalic acid to prepare the magnetic metal organic framework composite material with a sandwich structure. The synthesis method is simple and quick; the magnetic metal organic framework composite material obtained by synthesizing is high in specific surface area, good in biocompatibility and applicable to selective enrichment of phosphorylated peptide and MALDI-TOFMS detection in biological samples.

The invention discloses a process for purifying glufosinate-ammonium, which comprises: (1) adding glufosinate-ammonium hydrochloride into an alcohol R1OH to perform an esterification reaction, and after the reaction is accomplished, cooling, filtering, removing solvent from filtrate and obtaining ester product of glufosinate-ammonium; (2) adding the ester product of glufosinate-ammonium, which isobtained by step (1), into water solution of hydrochloric acid to perform a hydrolysis reaction, and obtaining glufosinate-ammonium hydrochloride by post treatment; (3) adding the glufosinate-ammonium hydrochloride obtained by the step (2) into an alcohol R2OH, introducing epoxy ethane and obtaining glufosinate-ammonium acid; and (4) adding the glufosinate-ammonium acid obtained by the step (3) into an alcohol R3OH, introducing ammonia gas, and obtaining glufosinate-ammonium after the reaction is finished. In the invention, the process for purifying glufosinate-ammonium comprises simple steps, the inorganic salt content in the obtained glufosinate-ammonium is low, and the purity of the obtained glufosinate-ammonium is high; the process for separating glufosinate-ammonium hydrochloride from HCl by epoxy ethane is more economic than the conventional process which adopts epoxypropane and epoxy chloropropane; and the method is very safe and has a very bright industrialization prospect.

The invention discloses a method for preparing xylylene diisocyanate (XDI) based on salification-phosgenation reaction. The method comprises the following steps of: (a) a salification reaction process of amine solution which is formed by xylylene diamine in an inert organic solvent and hydrogen chloride; (b) a hydrochloride centrifugal concentration process; (c) a high-pressure phosgenation process; and (d) a low-pressure phosgenation process. In the method, the salification reaction of the amine is kept performing in low-concentration hydrochloride solution all the time; and high-concentration hydrochloride solution participates in the phosgenation reaction to prepare the XDI. The process has a high time-space conversion rate and simultaneously ensures a good salification effect.