2779 results about "Hydrochloride" patented technology

The invention discloses a polyimidazolone compound as well as a preparation method and application thereof. The preparation method comprises the following steps: dissolving a bilateral alkyne ester compound, amidine hydrochloride, a catalyst and a desalting agent in an organic solvent, and carrying out polymerization reaction to obtain the polyimidazolone compound. The polyimidazolone compound with the five-membered ring is selectively generated, and the method has the advantages that monomers are easy to obtain, operation is easy, and by-products are low in toxicity. The polyimidazolone compound prepared by the invention has better machinability and has potential application value in the aspects of metal ion detection and biogenic amine detection.

The invention relates to the technical field of environmental materials and water treatment, in particular to a graphene amino silica gel composite adsorbent for heavy metal wastewater treatment and a preparation method thereof.The graphene amino silica gel composite adsorbent is prepared from # imgabs0 nanoparticles, an amino-functionalized silicon dioxide coating layer, carboxylated reduced graphene oxide, a polydopamine modification layer and tetraethyl orthosilicate; the coating is prepared from the following raw materials: 3-aminopropyltriethoxysilane, 3-mercaptopropyltrimethoxysilane, N-((4-vinyl benzyl) amino) diacetic acid, chitosan, beta-cyclodextrin, hexadecyl trimethyl ammonium bromide, polyethylene glycol, L-ascorbic acid, 1-ethyl-3-(3-dimethyl aminopropyl) carbodiimide hydrochloride and N-hydroxysuccinimide. The composite adsorbent shows excellent adsorption performance on various heavy metal ions, and the adsorption performance is far higher than that of traditional adsorption materials and existing composite adsorbents.

The invention discloses an anti-scale cross-linked polymer fracturing fluid and a preparation method thereof, and relates to the technical field of petroleum fracturing fluids. When the anti-scale cross-linked polymer fracturing fluid is prepared, allylamine hydrochloride and epoxy chloropropane react to prepare a double-bond chlorinated intermediate; reacting the double-bond chlorinated intermediate with lauramidopropyl dimethylamine to prepare a cationic monomer; copolymerizing a cationic monomer and acrylamide to prepare a cationic polymer; the preparation method comprises the following steps: reacting L-lysine with formaldehyde and phosphorous acid to prepare phosphoric acid modified lysine; reacting the phosphoric acid modified lysine with allyl glycidyl ether to prepare a phosphoric acid modified monomer; acrylamide and an anionic monomer are copolymerized to prepare an anionic polymer; the anionic polymer and the cationic polymer are dissolved in water to prepare the anti-scale cross-linked polymer fracturing fluid. The anti-scale cross-linked polymer fracturing fluid prepared by the invention has the advantages of scale prevention, good temperature resistance, good shear resistance and self-crosslinking.

A method of synthesizing the benzoate salt of 5-MeO-DMT comprising the step of treating the hydrochloride salt of 5-MeO-DMT with a base, prior to the addition of benzoic acid.

A flame-retardant laminated solid wood composite floor and a manufacturing method therefor. The manufacturing method comprising: first reacting dopamine hydrochloride with acryloyl chloride to generate a dopamine acrylamide monomer; by means of a double bond in the dopamine acrylamide monomer, carrying out a click reaction with a phosphate monomer containing a sulfydryl group, so as to introduce a catechol group into a side chain of the phosphate monomer and obtain a flame-retardant monomer containing the double bond; and then mixing pentaerythritol tetra(3-mercaptopropionate), pentaerythritol triacrylate, perfluorodecanethiol and the flame-retardant monomer containing the double bond to obtain a photocurable coating material. The coating material is photocured after being coated on the surface of a wood veneer, thus effectively improving the flame-retardant performance of the wood veneer; moreover, the adhesion between the coating layer and the wood veneer is excellent. The wood veneers are laminated in multiple layers, are glued and assembled into a layered structure, and then hot-pressed to form the solid wood composite floor, thus improving the comprehensive performance.

The invention belongs to the technical field of zinc battery electrolyte, and discloses application of pyridine hydrochloride as an electrolyte additive in stabilizing a zinc negative electrode and realizing four-electron transfer of a zinc-iodine secondary battery. The hydrochloride containing the pyridine structure is used as an electrolyte additive, molecules of the pyridine structure are adsorbed on the surface of the zinc negative electrode to form a shielding layer, the deposition / stripping reversibility of the zinc negative electrode is improved, stabilization of the zinc negative electrode can be achieved, and the problems of zinc dendritic crystal, corrosion and hydrogen evolution are solved. Meanwhile, molecules with pyridine structures can activate and stabilize I- / I0 / I < + > four-electron redox reaction, inhibit I < + > hydrolysis side reaction and improve the energy density and cycling stability of the zinc-iodine battery. The problem of poor electrochemical deposition / stripping reversibility of a zinc negative electrode and the problem of poor stability of positive valence I < + > species of an iodine positive electrode of a four-electron transfer reaction are solved. The electrolyte containing the additive is low in cost, simple in method, easy to produce and high in practical value.

The invention relates to the technical field of oil and gas field exploitation, and discloses a drag reducer for a multifunctional fracturing fluid and a preparation method thereof.The preparation method of the drag reducer for the multifunctional fracturing fluid comprises the steps that acrylic acid, acrylamide, 2-acrylamido-2-methylpropanesulfonic acid and modified itaconic acid are added into deionized water, stirring and mixing are conducted, and the drag reducer for the multifunctional fracturing fluid is obtained. Nitrogen is introduced for 30-40 min to remove oxygen, then azobis (isobutylamidine) hydrochloride is added, the mixture is stirred to react for 48-72 h at the temperature of 45-50 DEG C, and a polymer solution is obtained; and directly and uniformly mixing the polymer solution, the compatilizer and the modified nano silicon dioxide, and reacting in a magnetic stirrer at 60-70 DEG C for 1.5-2 hours to obtain the drag reducer for the multifunctional fracturing fluid. The drag reducer has a good drag reduction effect, and the hydrophobicity, the temperature resistance, the salt resistance and the shear resistance are improved.

A method of synthesizing the benzoate salt of 5-MeO-DMT comprising the step of treating the hydrochloride salt of 5-MeO-DMT with a base, prior to the addition of benzoic acid.

Provided herein is a pleuromutilin derivative containing a cycloalkyl group and preparation method and application thereof. Specifically, the pleuromutilin is reacted with p-toluenesulfonyl chloride to obtain an intermediate I, and the intermediate I is reacted with 1-amino-2-methylpropane-2-thiol hydrochloride to obtain an intermediate II, and then the intermediate II is reacted with cycloalkylcarbonyl chloride to obtain a target derivative. The synthesis process of these derivatives is simple, with a high yield and simple purification. These derivatives can effectively inhibit activities of Staphylococcus aureus and Streptococcus, and have superior activities to the marketed Tiamulin, and they also have good antibacterial activities against drug-resistant bacteria. In particular, the treatment effect of the derivative 2 of the target derivative is significantly superior to the clinical drugs Tiamulin and Valnemulin. They are suitable as new antibacterial drugs for prevention and treatment of infectious diseases caused by bacteria in humans or animals.

An advantageous isolated morphic form of trilaciclib which is 2′-((5-(4-methylpiperazin-1-yl)pyridin-2-yl)amino)-7′,8′-dihydro-6′H-spiro[cyclohexane-1,9′-pyrazino[1′,2′:1,5]pyrrolo[2,3-d]pyrimidin]-6′-one, for example in the form of a dihydrochloride salt or a dihydrochloride, dihydrate.

The invention provides a preparation method of 4-fluoro-3, 5-dimethylphenylhydrazine hydrochloride, which comprises the following steps: salifying 4-fluoro-3, 5-dimethylaniline serving as a substrate with concentrated hydrochloric acid, reacting with sodium nitrite to prepare a diazo solution, reducing the diazo solution into corresponding phenylhydrazine by using alkaline sodium sulfite as a reducing agent system, and reacting the 4-fluoro-3, 5-dimethylphenylhydrazine hydrochloride with the diazo solution to prepare the 4-fluoro-3, 5-dimethylphenylhydrazine hydrochloride. And acidizing the 2, 5-dimethyl phenylhydrazine to obtain corresponding phenylhydrazine hydrochloride. According to the preparation method, sodium sulfite which is low in cost and easy to obtain is used as a reducing agent, the defects that metal residues are high, the environment is prone to being polluted and the raw material cost is high due to the fact that a metal reducing agent is adopted when phenylhydrazine hydrochloride is prepared in the prior art are overcome, the reaction is completed in a water phase, no organic solvent is adopted, and the concept of green chemistry is met; and the problems of complicated post-treatment and easy pollution caused by the adoption of an organic solvent can be effectively avoided.

The invention relates to the technical field of coating liquid, and particularly discloses anti-reflection self-cleaning type coating liquid as well as a preparation method and application thereof. The invention provides anti-reflection self-cleaning type coating liquid. The anti-reflection self-cleaning type coating liquid is specifically prepared from, by weight, 12-18 parts of polymethyl methacrylate, 5-8 parts of composite sol, 3-6 parts of silane, 2-4 parts of inorganic materials, 1-3 parts of an anti-reflection agent and 30-40 parts of a solvent. The composite sol is obtained by carrying out water bath heat preservation reaction treatment on a natural polymer colloid and a styrene-acrylonitrile-glycidyl methacrylate copolymer through a dopamine hydrochloride aqueous solution; the inorganic material is formed by mixing silicon dioxide with the particle size of 10-30 nm and silicon dioxide with the particle size of 40-70 nm according to the weight ratio of (0.5-1.5): (5-8). The anti-reflection self-cleaning coating liquid prepared by the invention can obviously improve the light transmittance and self-cleaning property of photovoltaic glass; and the durability and the stability of the coating layer are excellent.

A salt of a substituted amino six-membered nitric heterocyclic compound, a crystal form thereof, a method for preparing same, and use thereof are provided. A dihydrochloride salt of a compound represented by formula (I) is a specific example. The salt can be prepared as a crystal form, the crystal form preferably having the following advantages: good solubility, low hygroscopicity, stable quality, and crystal form stability, thus being more easily developed into drugs as compared with the compound represented by formula (I) or other salts.

The invention belongs to the field of detection and analysis, and relates to a method for separating and detecting enantiomers in (S)-2-amino-3-[2-(tert-butoxy)-2-oxoacetamido] tert-butyl propionate hydrochloride. According to the method, HPLC is adopted for separation and detection, a polysaccharide derivative chiral chromatographic column is selected as a chromatographic column, a mobile phase A is a weak base aqueous solution, and a mobile phase B is acetonitrile and / or methanol. The method is strong in specificity, high in separation degree, high in accuracy, stable, reliable and high in sensitivity, and a simple, accurate, rapid and reliable detection method is provided for control of impurities in a starting material of (S)-2-amino-3-[2-(tert-butoxy)-2-oxoacetamido] tert-butyl propionate hydrochloride.

The invention relates to a rapid detection kit for large yellow croaker pyramidal worm, and belongs to the field of pathogen biological diagnosis in aquaculture. The kit comprises a nucleic acid releasing agent and further comprises a primer and a probe which are used for detecting the large yellow croaker pyramidal worm. The kit comprises a nucleic acid releaser; the formula of the nucleic acid releasing agent comprises tris (hydroxymethyl) aminomethane hydrochloride with the final concentration of 100 mM, sodium chloride with the final concentration of 100 mM, sodium dodecyl sulfate with the final concentration of 1 wt%, sodium alpha-olefin sulfonate with the final concentration of 3 wt%, sodium lauroyl glutamate with the final concentration of 1.2 wt%, betaine with the final concentration of 1 wt% and water as a solvent. The sequences of the primer and the probe for detecting the Pseudosciaena crocea pyramidal are 5 '-TATGGGCAATTCTGAATCCT-3', 5 '-TCTTTTCTGATCCCTGAAT-3' and 5 '-FAM-GTCGGTGGAGTGATTTGTTTG-3'. The kit disclosed by the invention is simple to operate, provides a tool for diagnosis, prevalence monitoring, prevention and control of the Pseudosciaena crocea pyramidal, and has a very high application value.

The invention relates to the technical field of organic synthesis, and discloses a preparation process of (S)-3-aminobutyronitrile hydrochloride, which comprises the following steps: by taking a compound S1 as an initial raw material, sequentially implementing chlorination, amino protection, cyano substitution and deprotection reaction through four-step continuous reaction (M01 preparation, M02 preparation, M03 preparation and M04 preparation), and finally obtaining the high-purity (S)-3-aminobutyronitrile hydrochloride. The preparation process disclosed by the invention is simple and convenient to operate, mild in reaction condition, stable in yield of each step, high in safety and suitable for industrial large-scale production, and can be used for carrying out standard treatment on the cyanide-containing wastewater, and has a relatively good application prospect.

An advantageous isolated morphic form of trilaciclib which is 2′-((5-(4-methylpiperazin-1-yl)pyridin-2-yl)amino)-7′,8′-dihydro-6′H-spiro[cyclohexane-1,9′-pyrazino[1′,2′:1,5]pyrrolo[2,3-d]pyrimidin]-6′-one, for example in the form of a dihydrochloride salt or a dihydrochloride, dihydrate.

The invention belongs to the field of feeds, and discloses a biological feed containing a microbial microcapsule preparation and a preparation method of the biological feed. The biological feed is prepared from the following components in parts by weight: 90 to 93 parts of wall-broken rhodopseudomonas palustris powder, 2 to 3 parts of lysine hydrochloride, 0.1 to 0.5 part of methionine, 0.1 to 0.5 part of threonine, 0.3 to 1 part of arginine, 2 to 3 parts of calcium hydrophosphate, 1 to 2 parts of calcium carbonate, 0.5 to 1.2 parts of an antioxidant additive, 0.3 to 0.8 part of modified nano montmorillonite and 1 to 5 parts of a microbial microcapsule preparation. According to the biological feed, the wall-broken rhodopseudomonas palustris serves as basic nutrition and a main microorganism source of the feed and is matched with the compound probiotics of the microorganism micro-capsule preparation, the intestinal nutrition utilization rate is effectively increased, meanwhile, the antioxidant additive is added, and the problems that a single additive is narrow in function and prone to oxidation are solved; the modified nano montmorillonite is added to solve the problem of antagonism of toxin adsorption and mineral absorption.

An advantageous isolated morphic form of trilaciclib which is 2′-((5-(4-methylpiperazin-1-yl)pyridin-2-yl)amino)-7′,8′-dihydro-6′H-spiro[cyclohexane-1,9′-pyrazino[1′,2′:1,5]pyrrolo[2,3-d]pyrimidin]-6′-one, for example in the form of a dihydrochloride salt or a dihydrochloride, dihydrate.

The invention relates to the technical field of membrane separation, in particular to a composite forward osmosis membrane based on mussel bionic interface enhancement and a preparation method thereof. The preparation method comprises the following steps: immersing a base material in a dopamine hydrochloride solution for oscillation reaction to obtain a modified base material; the surface of the modified base material is coated with a membrane casting solution in a blade coating mode, then phase inversion is carried out, the residual solvent is removed, then airing is carried out, and the composite forward osmosis membrane based on mussel bionic interface enhancement is obtained. By introducing the mussel bionic polydopamine intermediate layer, the long-standing technical contradictions of poor interfacial compatibility and weak binding force between the hydrophobic substrate and the hydrophilic separation layer are ingeniously solved, and the internal concentration polarization effect is remarkably inhibited. The prepared composite membrane has the advantages of high water flux, low salt reverse flux, stable structure and the like, and has wide application prospects in the fields of water treatment and substance separation.

The present disclosure provides a hydrochloride or hydrochloride hydrate of a compound of Chemical Formula 1 and a pharmaceutical composition comprising the same.

The invention relates to the technical field of in-vitro diagnostic kits, in particular to carboxyl polystyrene microspheres, a preparation method and application of the carboxyl polystyrene microspheres in a kit for quantitatively detecting MxA. The preparation method of the carboxyl polystyrene microspheres comprises the steps that firstly, polystyrene microspheres with the surface rich in aldehyde groups are prepared through a soap-free emulsion polymerization method; then carrying out a Schiff alkali reaction with 2-aminoethyl methacrylate hydrochloride to carry out double bond modification on the surface of the microsphere, and meanwhile, improving the hydrophilicity of the microsphere by an ester group and an imino group; and finally, carrying out sulfydryl-double bond addition reaction on the polystyrene microspheres and mercaptosuccinic acid to generate the polystyrene microspheres rich in carboxyl on the surfaces. The carboxyl polystyrene microspheres prepared by the invention can improve the binding efficiency of latex and an MxA antibody, so that the detection sensitivity is improved, the purpose of high-sensitivity quantitative detection of MxA protein can be achieved, and the detection time is greatly shortened.

The invention relates to the technical field of medicines. The invention provides sapropterin hydrochloride powder and a preparation method thereof. The sapropterin hydrochloride powder comprises the following components in percentage by mass: 15%-30% of sapropterin hydrochloride, 50%-60% of a filler, 8%-18% of a cosolvent, 3%-6% of a lubricant, 1%-3% of a flavoring agent and 0.1%-1% of an antioxidant. The sapropterin hydrochloride powder prepared by adopting the technical scheme has the characteristics of good solubility, high stability, high bioavailability and convenience in taking.

The invention provides arbidol hydrochloride emulsifiable paste for inhibiting HSV-2 and a preparation method of the arbidol hydrochloride emulsifiable paste. The hydrochloric acid arbidol emulsifiable paste for inhibiting HSV-2 comprises the following components in percentage by weight: 0.5-2% of micronized hydrochloric acid arbidol; 70%-95% of a cream matrix; 8%-12% of an absorption enhancer; wherein the particle size D90 of the micronized arbidol hydrochloride is less than or equal to 10 microns. The arbidol hydrochloride emulsifiable paste for inhibiting the HSV-2 is provided. According to the arbidol hydrochloride emulsifiable paste for inhibiting HSV-2, the micronized arbidol hydrochloride with the particle size D90 smaller than or equal to 10 microns, the emulsifiable paste matrix and the absorption enhancer are compounded for use, so that the uniformity of the arbidol hydrochloride emulsifiable paste for inhibiting HSV-2 can be improved, and the continuous and stable release speed of the arbidol hydrochloride emulsifiable paste for inhibiting HSV-2 can be ensured; the arbidol hydrochloride emulsifiable paste for inhibiting the HSV-2 has the advantages that the long-term storage performance is stable, and the arbidol hydrochloride emulsifiable paste for inhibiting the HSV-2 is better suitable for treating acute large-area HSV-2.

The invention belongs to the technical field of microorganisms and fermentation engineering, and particularly relates to application of bifidobacterium longum subsp. Infantis Y46 in the aspects of enhancing cell defense and repair and regulating metabolic homeostasis of a host. The strain is isolated from infant feces. Animal experiments prove that living cell thalli of the bifidobacterium longum subsp. Infantis Y46, which are obtained by culturing an MRS liquid culture medium added with L-cysteine hydrochloride (0.05%, v / v), can significantly enhance the oxidative stress resistance of an organism and reduce the level of active oxygen in the organism compared with a control bacterium bifidobacterium longum subsp. Infantis 15697. Transcriptomics analysis shows that the bifidobacterium longum subsp. Infantis Y46 can enhance self-protection of cells and improve physiological imbalance caused by external pressure by regulating related signal channels of an organism. The action mechanism is closely related to signaling pathways related to cell defense, metabolic homeostasis and barrier functions. The invention provides a new strain resource and an application scheme for developing functional food or medicinal preparations for enhancing the health defense function of a human body.

The invention belongs to the technical field of bioengineering medicines, and particularly relates to a gel dressing for repairing skin wounds and a preparation method of the gel dressing. The anti-fouling coating is prepared from the following raw materials in parts by weight: 65 to 75 parts of polyvinyl alcohol, 14 to 20 parts of sodium alginate, 4 to 8 parts of sodium carboxymethyl cellulose, 1 to 3 parts of sodium hyaluronate, 12 to 22 parts of glycerol, 1 to 3 parts of surface anti-fouling additive, 6 to 10 parts of antibacterial microcapsule and 2 to 2.8 parts of compound ion. According to the invention, a PVA freeze-thaw physical network and an alginic acid Ca / Zn composite ion network cooperate to limit a pore channel, so that stable forming is realized; a chitosan / sodium tripolyphosphate microcapsule is prepared from polyhexamethylene biguanide hydrochloride and covered with sodium alginate, release sensitive to pH / ionic strength, acceleration in an inflammation stage and self-limiting in a later stage are constructed, and long-acting bacteriostasis is formed by SA-Zn site slow release; the stability and staged adaptation are highlighted through processes such as encapsulation, low-shear doping and the like and raw material synergy.

This invention relates to a method for using a low-content ruthenium-based catalyst modified with nitrogen and oxygen ligands in the hydrochlorination of acetylene. The invention utilizes 2-pyridine carboxylate as a ligand, commercial activated carbon as a support, trace amounts of ruthenium as the main active component, and water as a solvent. An improved synthesis procedure yields a low-content ruthenium-based catalyst with ruthenium ions coordinated by a modifier and commercial activated carbon as a support, significantly improving catalyst performance while reducing ruthenium content. This catalyst exhibits high activity and vinyl chloride selectivity in the fixed-bed hydrochlorination of acetylene to vinyl chloride, and its low cost makes it highly valuable for industrial applications. The ruthenium loading is 0.1%, and the reaction gas space velocity is 170 h⁻¹. ‑1 V (C2H2) / V (HCl) With a ratio of 1:1.05 and a reaction temperature of 180℃, the acetylene conversion rate can reach 84.3%, the vinyl chloride selectivity is greater than 99%, and the activity remains basically unchanged within 10 hours.

The invention relates to a continuous production method of high-purity tetraethoxysilane, and belongs to the technical field of tetraethoxysilane preparation. The method comprises a raw material pretreatment stage and a purification and rectification stage: in the pretreatment stage, silicon tetrachloride and ethanol are subjected to an esterification reaction in a molar ratio of 1: (3-4) under the protection of nitrogen, the pH is adjusted to be neutral through triethylamine, and triethylamine hydrochloride is removed through reduced pressure distillation; then, a cerium oxide-molecular sieve composite adsorbent with the specific surface area larger than or equal to 800 m / g and the pore diameter of 2-5 nm is adopted for dehydration under the pressure of 0.8-1.2 MPa till the water content is smaller than or equal to 5 ppm, and volatile impurities are removed through high-purity nitrogen purging; in the purification stage, metal ions and Cl are synergistically removed through a titanate modified resin layer and a nano TiOtube layer, and then step-by-step separation is performed through a four-stage differential pressure rectifying tower. Through collaborative optimization of structural design of the composite adsorbent, construction of an organic-inorganic hybrid interface of the resin layer and pressure gradient rectification, 72-hour continuous production is achieved, the single-pass yield of the product is 92%, and the total amount of metal impurities is smaller than or equal to 5 ppb.

The invention discloses a zinc-bromine flow battery modified diaphragm which comprises a base diaphragm and a modified layer, the component of the modified layer is dopamine hydrochloride, and a preparation method of the zinc-bromine flow battery modified diaphragm comprises the following steps: S1, preparing a dopamine hydrochloride solution; s2, preparing a modified diaphragm: soaking the base membrane in a dopamine hydrochloride solution, adding a buffer solution, standing, and drying to obtain the modified diaphragm. The hydrophilicity of the diaphragm is improved by using dopamine through a bionic method, alkaline dopamine is very easy to infiltrate through a simple and controllable reaction process, a modified membrane is successfully prepared from a base membrane, the method keeps the original high mechanical property and acid-base stability of the base membrane, the hydrophilicity of the surface of the base membrane is remarkably enhanced, and the service life of the membrane is prolonged. In addition, some dopamine hydrochloride molecules are immersed into holes to reduce the average pore size of the film, so that the free shuttling of bromide ions is effectively inhibited.

A method for preparing exosomes is provided. The method includes preparing a human platelet, treating the human platelet with a buffer to obtain a platelet solution, centrifuging the platelet solution, and collecting supernatant of the centrifuged platelet solution to obtain an exosome solution. The buffer is calcium ion buffer, phosphate buffered saline (PBS), tris(hydroxymethyl)aminomethane hydrochloride (Tris-HCl) buffer, or 2-[4-(2-hydroxyethyl)-1-piperazinyl]ethanesulfonic acid (HEPES) buffer.