317 results about "Succinimide" patented technology

The invention relates to an antibody endocytosis efficiency detection method based on fluorescence resonance energy transfer, and belongs to the technical field of antibody endocytosis detection. The method comprises the following steps: coupling succinimide ester with an amino-containing compound to obtain a quenching agent, incubating an antibody to be detected and a target cell together, adding a fluorescence-labeled secondary antibody to carry out endocytosis reaction, removing an extracellular fluorescence signal by using the quenching agent after the reaction is finished, and detecting an intracellular fluorescence signal to obtain the endocytosis percentage of the antibody to be detected. The detection method provided by the invention is based on a fluorescence resonance energy transfer principle, an intracellular signal direct detection method in the prior art is optimized, and an extracellular fluorescence signal is removed, so that a detection system has higher sensitivity. The quenching agent provided by the invention can also be combined with an acid eluent in the prior art to further reduce an extracellular signal background value and improve the sensitivity of a detection system, can be applied to high-throughput detection of a to-be-detected antibody, is high in sensitivity and low in detection cost, and has a good application prospect.

The invention belongs to the technical field of biological materials and ultrasonic printing, and particularly discloses a biological adhesive for ultrasonic printing and preparation and application thereof. The biological adhesive comprises a heat-sensitive main body material and a chemical adhesion component, the heat-sensitive main body material comprises hydroxybutyl chitosan, and the chemical adhesion component comprises polyacrylic acid-N-hydroxysuccinimide ester. The bioadhesive has excellent ultrasonic responsiveness, formability and bioadhesion performance, directional deposition, in-situ solidification and tissue surface adhesion can be achieved in a non-contact and accurately-controlled ultrasonic printing system, and the bioadhesive is suitable for various biomedical scenes such as tissue repair, minimally invasive medicine, biological device construction and drug delivery interface printing.

The invention relates to the technical field of new material application, and discloses a magnetic bead material for enriching a sulfydryl peptide fragment and a preparation method thereof.The magnetic bead material prepared from micron carboxyl magnetic beads, dodecane dicarboxylic acid dihydrazide and SPSP has a long chemical reaction connecting arm, so that a reaction group has the better freedom degree, the reaction with sulfydryl is better facilitated, and the magnetic bead material can be used for enriching the sulfydryl peptide fragment. The enrichment efficiency is relatively high. When the magnetic bead material is prepared, micron carboxyl magnetic beads and dodecane dicarboxylic acid dihydrazide are based on hydrazine group and carboxyl condensation, the condensation reaction is more selective and more stable, the reaction is carried out under a milder condition, the reaction product is stable, and the reaction efficiency is higher at a lower reaction temperature. Dodecane dicarboxylic acid dihydrazide and SPSP are based on a reaction of N-succinimide and hydrazine, N-succinimide has high specificity to amino-containing molecules, side reactions are reduced, the reaction is generally carried out at room temperature, strong acid and alkali conditions are not needed, and protection of other sensitive groups is facilitated.

The invention discloses a non-phosphorus reverse osmosis scale inhibitor and a preparation method thereof, and relates to the technical field of industrial water treatment.The non-phosphorus reverse osmosis scale inhibitor is prepared from, by weight, 10 parts of purified humic acid, 40-60 parts of alkalized acrylic acid-succinimide-hydroxypropyl methacrylate copolymer, 4-8 parts of sodium polyepoxysuccinate and 5-20 parts of water. Compared with the prior art, the scale inhibitor is high in environment-friendly compliance, excellent in scale inhibition performance, scientific and efficient in raw material treatment and high in product scale inhibition rate, meets the environment-friendly emission standard, and is suitable for reverse osmosis membrane scale inhibition treatment in the industries of electric power, chemical engineering, seawater desalination and the like.

The invention discloses a bionic self-crimping material and application in the nerve field, and relates to the technical field of nano materials. The preparation method comprises the following steps: firstly, carrying out ultraviolet photopolymerization on acrylic acid and acrylic acid-N-hydroxysuccinimide, adding chitosan and glutaraldehyde to form hydrogel, and introducing epigallocatechin gallate into a chitosan-acrylic acid network. The material is rapidly and autonomously curled into a tube shape after being in contact with wet nerves, glutaraldehyde is directionally and orderly diffused by adopting a three-channel micro-fluidic chip, and the fineness is improved, so that the matching degree of nerve broken ends with different thicknesses is increased; the surface active groups of the material and the natural component chitosan cooperate to realize suture-free fixation; the plant phenol antioxidant removes free radicals at nerve injury parts; the degradation period is synchronous with natural healing of nerves, and secondary operation for taking out is not needed. The electroneurographic signals using the material are transmitted more smoothly, the target muscle atrophy degree is reduced, and the limb movement function is recovered to be close to the normal level.

The present invention relates to a microneedle-based transdermal delivery patch fabricated from a hydrogel composed of polyvinyl alcohol (PVA), arginine-modified chitosan, and a crosslinker. The arginine-modified chitosan is prepared by reacting a chitosan solution with an arginine solution preactivated with N-hydroxy succinimide and 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide at a specific pH. The hydrogel's formulation further comprises a PVA concentration ranging from 10% to 12% (w / v). arginine-modified chitosan and PVA solution are mixed in a 1:2 ratio by volume and are crosslinked using trimethyl orthoformate (TMOF). The patch is further loaded with curcumin, with a concentration of 120μg per patch, demonstrating a 70% release over 48 hours in a controlled manner. This invention represents the first application of PVA crosslinked arginine-modified chitosan hydrogel loaded with curcumin specifically for animal wound healing, providing enhanced wound healing and antibacterial efficacy.

The invention discloses a probe Cvs-B-NHS based on a coumarin derivative as well as a preparation method and application of the probe Cvs-B-NHS. According to the fluorescent probe Cvs-B-NHS of the coumarin derivative, a coumarin mother nucleus and succinimide ester are organically combined, the excellent fluorescence characteristic of coumarin is reserved, efficient protein labeling capacity is achieved, high-sensitivity fluorescence signal output and specific labeling of protein are achieved, and the fluorescent probe Cvs-B-NHS has the advantages of being high in sensitivity and high in sensitivity. And the accuracy and reliability of protein detection and imaging are improved. The invention discloses a TDP-43 protein phase separation labeling method based on a Cvs-B-NHS probe, which provides a new means for researching the action mechanism of a TDP-43 (G335D) mutant in neurodegenerative diseases, and is beneficial to promoting the research progress in the field of neurodegenerative diseases. The application of the Cvs-B-NHS probe in evaluating the polarity change of the microenvironment in the protein liquid-liquid phase separation process in the cytoplasm environment caused by mitochondrial signal disturbance provides a powerful tool for the research of the protein phase separation microenvironment.

The invention provides a synthesis method of an OLED polycyclic fused thiophene compound, and relates to the technical field of material synthesis, and the synthesis method comprises the following steps: providing and mixing 2-naphthalene sulfonic acid and dichloromethane, dropwise adding an N-bromosuccinimide solution into the mixture under the protection of inert gas, and reacting to obtain an intermediate A; dissolving the intermediate A, then adding sodium hydroxide, 4-bromophenylboronic acid, water and tetrakis (triphenylphosphine) palladium, and reacting to obtain an intermediate B; dissolving the intermediate B, adding sulfonic acid and phosphorus pentoxide, and reacting to obtain an intermediate C; adding the intermediate C into tetrahydrofuran, dissolving, adding lithium aluminum hydride under inert gas, and reacting to obtain a target compound. According to the method, the chemical reaction efficiency of the intermediate C is high, and the yield and LC purity of a target product are relatively high.

The invention provides a thermo-sensitive triblock copolymer with a lateral group containing polyethylene glycol and a preparation method of the thermo-sensitive triblock copolymer, and relates to the field of polymer synthesis. The preparation method comprises the following steps: carrying out a reaction on hydroxyl-terminated polyether PAGE and single carboxyl-terminated polyethylene glycol monomethyl ether (mPEG-COOH) under the action of N-bromosuccinimide to prepare a polymer brush PAGE-g-mPEG; and reacting the polymer brush PAGE-g-mPEG with poly (N-isopropylacrylamide) to generate a thermo-sensitive triblock copolymer of which the side group contains polyethylene glycol. The thermo-sensitive triblock copolymer disclosed by the invention is endowed with good biocompatibility, hydrophilicity and low-temperature performance, has a good thermo-sensitive characteristic, and can be widely applied to the fields of drug-loaded controlled release, sewage treatment and nanoparticles; the invention also provides a preparation method of the thermo-sensitive triblock copolymer, which overcomes the defects of harsh reaction conditions and easy chain extension reaction, and realizes accurate control of the molecular weight of the prepared copolymer.

The invention belongs to the technical field of petrochemical anticorrosion, and provides a multifunctional water-soluble corrosion inhibitor for an oil refining device and a preparation method of the multifunctional water-soluble corrosion inhibitor, and the corrosion inhibitor is a functionalized grafted copolymer obtained by a ring-opening reaction of a succinimide ring on a polysuccinimide intermediate and a plurality of amino-containing compounds; the amino-containing compound at least comprises gemini imidazoline quaternary ammonium salt with a corrosion inhibition function; a polyaspartic acid chain segment precursor with scale inhibition and dispersion functions; the organic amine compound has targeted chelating and pH buffering functions and contains sulfonic acid groups and carboxyl groups; according to the invention, double-anchored gemini imidazoline quaternary ammonium salt is taken as a corrosion inhibition core, and a polysuccinimide ring-opening grafting process is combined, so that chain segments with corrosion inhibition, scale inhibition, targeted buffering and temperature-sensitive self-repairing functions are covalently integrated into a same polymer main chain, and multi-functional efficient protection of a single agent in an oil refining device water phase system is realized.

The invention discloses a method for preparing chiral succinimide through asymmetric hydrogenation of alpha-alkylene succinimide under the catalysis of nickel. The method comprises the following steps: in a solvent, under certain hydrogen pressure and temperature, alpha-alkylene succinimide represented by a general formula (1) is hydrogenated into a chiral succinimide compound represented by a general formula (2) by a nickel chiral catalyst; the structural formulas of the general formulas (1) and (2) are shown in the specification. The method is mild in reaction condition, simple and convenient to operate, capable of achieving good yield and efficiency and wide in application prospect.

A lubricating composition comprises an oil of lubricating viscosity, a phenolic antioxidant, a sulfurized organic compound having an active sulfur content of no more than 8% by weight, and optionally one or more performance additives selected from the group consisting of succinimide dispersants and detergents. Further, a method for improving the oxidative stability of a lubricating oil in an engine comprises supplying to the engine a lubricating composition comprising an oil of lubricating viscosity, a phenolic antioxidant, a sulfurized organic compound having an active sulfur content of not more than 8% by weight, and optionally one or more performance additives selected from the group consisting of succinimide dispersants and detergents.

A composition for an electrolytic capacitor and an electrolytic capacitor including the composition is provided. The composition includes an intrinsically conductive polymer and an electrolyte solution. The electrolyte solution includes an organic solvent, an ionic salt compound and a succinimide-based compound.

Various examples are provided related to functionalization for sensing of antibodies. In one example, a method for functionalizing a test strip includes cleaning a gold surface of an electrode of a test strip; submerging the cleaned gold surface in a 3-Mercaptopropanyl-N-hydroxysuccinimide ester solution; cleaning channels of the test strip; injecting an antibody into the channels; sealing the injected antibody in the test strip; storing the sealed test strip at a controlled temperature; and deactivating unfunctionalized groups. In another example, a method includes connecting a functionalized test strip to a strip connector; generating a test pattern that is passed through the functionalized test strip and input into a gate terminal of a MOSFET in a readout block; converting a readout signal into a frequency signal; and counting the frequency signal at fixed intervals to generate a counter output, and displaying a sample concentration based upon the counter output.

The present invention discloses an electrochemiluminescent compound, a preparation method thereof and an application thereof, wherein the structural formula of the electrochemiluminescent compound is: wherein n is 100-200, R1, R2, R3 and R4 are all selected from one of a Y group and a hydrogen group, and at least one of R1, R2, R3 and R4 is a Y group. The preparation method of the electrochemiluminescent compound comprises the following steps: dissolving an iridium-containing complex, N, N-diisopropylethylamine, N, N, N', N'-tetramethyl-O-(N-succinimide) urea tetrafluoroborate in N, N-dimethylformamide and mixing; adding a polyethyleneimine solution, performing an amide reaction, separating, and obtaining the electrochemiluminescent compound. The electrochemiluminescent compound (Ir-PEI) of the present invention can improve the water solubility of the iridium-containing complex, can also be used as a coreactant unit in the molecule to promote the generation of ECL signals, and can be used as an ECL active material to construct and prepare an iridium ECL reagent.

The invention relates to the technical field of chemical oil-displacing agents for tertiary oil recovery, and particularly discloses a magnetic nano oil-displacing agent and a preparation method thereof. The preparation method comprises the following steps: S1, taking purple phosphorus nanosheets, ferrous sulfate, ferric chloride and ammonia water as raw materials to react to obtain magnetic purple phosphorus nanosheets; s2, reacting the polymer A with ethylenediamine to obtain an aminated polymer A; s3, adding the aminated polymer A or polymer B and 4-dimethylaminopyridine 1, 3-dicyclohexylcarbodiimide into an aqueous solution of the magnetic purple phosphorus nanosheet, so as to obtain a modified magnetic purple phosphorus nanosheet; s4, performing ammonification reaction on the surfactant to obtain an aminated surfactant; and S5, adding an aminated surfactant into the modified magnetic purple phosphorus nanosheet aqueous solution, then adding N-hydroxysuccinimide and 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride, and carrying out a reaction to obtain the magnetic nano oil displacement agent. The oil-displacing agent disclosed by the invention can realize magnetic recovery while realizing a viscosity reduction effect so as to improve the oil recovery rate, and waste of raw materials is avoided.

The application discloses an anticoagulant biomaterial for blood purification and a preparation method and application thereof, and comprises the following steps: providing an amphiphilic copolymer P(AA-MMA); blending polyethersulfone, P(AA-MMA) and a solvent, stirring at a set temperature to obtain a casting solution, and preparing a blending membrane from the casting solution; soaking the blending membrane in a 2-morpholine-4-yl ethanesulfonic acid buffer solution containing argatroban, 1-ethyl-(3-dimethylaminopropyl) carbonyl diimide and hydroxy succinimide, and reacting at room temperature to obtain an argatroban grafted blending membrane, namely the anticoagulant biomaterial. The method improves the hydrophilicity of the membrane, reduces the albumin adsorption of the membrane, reduces the adhesion of platelets on the membrane, prolongs the coagulation time APTT, PT and TT of the membrane, and is better in biocompatibility and enhanced in anticoagulation performance.

The application discloses a fuel oil stabilizer for high-viscosity residual oil blending. The fuel oil stabilizer comprises, in percentage by weight, 1-15% of a fatty amine, 0.1-1.5% of a mono-polyisobutene bis-succinimide, 0.1-2% of a non-ionic surfactant alkylphenol polyoxyethylene-polyoxypropylene alcohol ether, 1-30% of alkyl imidazole ionic liquid and / or quaternary ammonium salt ionic liquid, 10-30% of polyvinyl pyrrolidone, 10-20% of an antifoaming agent, and the rest of hydrogenated white oil. The stabilizer has good compatibility, dispersibility, aging resistance and thermal stability for high-viscosity residual oil blending fuel oil.

The invention relates to the field of slow-release fertilizers, in particular to preparation of a hydrogel slow-release fertilizer. The invention discloses a preparation method of a slow release fertilizer of polyaspartic acid, carboxymethyl cellulose hydrogel, stearic acid and urea. Comprising the following steps: (1) preparing polysuccinimide, (2) preparing a polyaspartic acid gel solution by using the polysuccinimide, and then preparing a polyaspartic acid / carboxymethyl cellulose hydrogel solution by using the polyaspartic acid gel solution; the method further comprises the following steps: (3) preparing stearic acid / urea particles; 4, the polyaspartic acid / carboxymethyl cellulose hydrogel solution and the stearic acid / urea granules are used for preparing and obtaining the polyaspartic acid-carboxymethyl cellulose hydrogel-stearic acid-urea slow-release fertilizer.By means of the method, the slow-release fertilizer with the dual functions of water retention and slow release can be prepared and obtained.

The invention belongs to the field of preparation of conjugated microporous polymers, and particularly discloses a method for synthesizing a conjugated microporous polymer through metal-free catalysis and application of the conjugated microporous polymer. According to the method, triphenylamine (TPA) is taken as a monomer, N-iodosuccinimide (NIS) is introduced to serve as an iodination reagent, the synergistic catalysis of trifluoromethanesulfonic acid (TfOH) is combined, and the synthesis of the conjugated microporous polymer (TPA-CMPs) is successfully realized under the condition that a metal catalyst is not needed. The obtained CMPs material has ultrahigh specific surface area and excellent iodine adsorption capacity, no metal participates in the whole process, the problems of high pollution, high cost and the like in the traditional metal catalytic synthesis process of CMPs are effectively solved, a new thought is provided for green chemical synthesis and functional material development, and the CMPs material has good application prospects in iodine vapor adsorption and iodine adsorption. The catalyst can also be applied to the fields of catalytic carriers, gas separation, environment restoration and the like and has wide application prospects.

A compound having a structure according to Formula I wherein: A is a hydrocarbyl succinimide; n = 1 to 10; m = 0, 1 or 2; and R is a nitrogen-containing heterocyclic moiety

The invention discloses a kind of artificial metabolic enzyme targeting mitochondria and its preparation method and application, relate to the field of biomedical material technology, the method comprises the following steps:Activated carbon is mixed and stirred with phosphomolybdic acid solution to obtain POM / AC;Mixed with acetylacetonate platinum (II) solution, reduction treatment is carried out to obtain Pt-POM / AC;It is dispersed in ethanol, 3-aminopropyltriethoxysilane is added and stirred, and solid A is obtained by freeze drying;(3-carboxypropyl) triphenylphosphine bromide, dimethyl sulfoxide and 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride are mixed, stirred in dark, N-hydroxysuccinimide is added, activated in dark, and solution B is obtained;Solid A is dissolved, mixed with solution B, stirred in dark, centrifuged, washed and dried, and the artificial metabolic enzyme targeting mitochondria is obtained.The artificial metabolic enzyme can be effectively taken up by tumor cells, and combined radiotherapy anti-tumor effect is better, and there is greater application value.

The invention belongs to the technical field of organic ultrathin nanomaterials, and particularly relates to a photoresponse type polymer ultrathin nanosheet as well as a preparation method and application thereof. The preparation method comprises the following steps: (1) adding dicyclohexylcarbodiimide, N-hydroxysuccinimide, N, N-diisopropylethylamine and 4-carboxyl phenylboronic acid pinacol ester into a solvent, and reacting to obtain an intermediate product; (2) carrying out heating reaction on the intermediate product, triethylene glycol and a catalyst to obtain a phenylboronic acid pinacol ester derivative; (3) adding 4, 4-dibromo azobenzene, a phenylboronic acid pinacol ester derivative, a palladium catalyst and potassium carbonate into a solvent for reaction to obtain an amphiphilic alternating copolymer; and (4) dispersing the amphiphilic alternating copolymer in a solvent for self-assembly to obtain the amphiphilic alternating copolymer. According to the invention, a photoresponse group azobenzene structure is introduced into a polymer main chain, so that the ultrathin organic material is endowed with a unique photoresponse characteristic; the method is simple and easy to implement, good in repeatability and high in stability.

The present invention belongs to the technical field of sealants. Disclosed are a low-viscosity non-toxic silane-terminated polyether resin and a preparation method therefor. The preparation method for the silane-terminated polyether resin comprises: with succinic anhydride and a polyether polyol as raw materials, preparing a polymer under the catalysis of an acid catalyst; adding N-hydroxysuccinimide and a carbodiimide-type catalyst to the polymer, stirring and reacting same; and dropwise adding an aminoalkoxysilane coupling agent to the system for termination, so as to prepare the silane-terminated polyether resin. The present invention uses the cheap succinic anhydride and polyether polyol for reaction, so as to achieve chain extension and also convert the hydroxyl at the terminal end of the polyether polyol into carboxyl having higher activity, thereby facilitating subsequent modification; the present invention avoids isocyanate-based coupling agents or tin-series catalysts which are expensive and toxic, thus being safe and nontoxic; and the obtained silane-terminated resin contains only two amide bonds on the terminal end, which effectively reduces the viscosity of products, thus facilitating the subsequent use of the products.

This invention relates to the field of lyophilized formulation technology, specifically disclosing an esupagglutide α-nano-lyophilized micelle and its preparation method. The micelles of this invention utilize polylactic-co-hydroxyacetic acid copolymer and sodium phosphatidylglycerol as micelle carriers, with arginine and cysteine ​​providing branching synergistic effects. Homogenization via film formation and low-temperature lyophilization yield lyophilized nano-micelle powder. The nano-micelle powder reduces protein oxidative decomposition during lyophilization, decreases impurity fragments, and reduces various non-fucose glycosylation, basic components (succinimide, methionine oxidation products), N-terminal deletion, Asn deamidation, and Met and Trp residue oxidation impurities that affect product quality. Product quality analysis and animal experiments after reconstitution show good resistance to impurities and degradation risk. The reconstituted esupagglutide α-nano-micelle system exhibits better stability and sustained-release properties, enhancing the hypoglycemic sustained-release effect 72 hours after injection, significantly improving upon conventional non-micelle formulations.

The invention relates to a preparation method of alpha-bromo-carboxylic acid. The method comprises the following steps: under the protection of nitrogen, dissolving a malonic acid substrate, N-bromosuccinimide (NBS) and pyridine in a reaction solvent, and reacting for 1 hour at 50 DEG C under the irradiation of blue light; and separating the crude reaction product through column chromatography or preparative plate chromatography to obtain the target delta-bromo-carboxylic acid compound. The method has the advantages of mild reaction conditions, simple operation, easily available raw materials, low cost, and good functional group compatibility and substrate universality. In the obtained product, due to high reaction activity of bromine atoms, the bromine atoms can be further derived into various alpha-heteroatom substituted carboxylic acids, and the product has application potential in the fields of synthetic chemistry, drug research and development and the like.

Provided is a lubricating oil composition containing a base oil (A), a metal-based cleaning agent (B) containing a magnesium sulfonate (B1), a boron-modified succinimide (C), and an organic zinc dithiophosphate (D), wherein the atomic content of phosphorus is 500-900 mass ppm on the basis of the total amount of the lubricating oil composition. The lubricating oil composition is substantially free of tetrapropenylphenol, and is used to lubricate equipment mounted on motorcycles.

The invention discloses a lubricating oil additive composition. The lubricating oil additive composition is prepared from the following components in percentage by mass: 10 to 30 weight percent of zinc dialkyl dithiophosphate, 10 to 30 weight percent of succinimide dispersing agent, 15 to 40 weight percent of metal clearing agent and 5 to 10 weight percent of dialkyl dithiophosphate acrylate anti-wear agent, 10-20 wt% of an alkyl biimidazole phosphate ionic liquid, and 5-10 wt% of an alkylated diphenylamine antioxidant. The alkyl bis-imidazole phosphate ionic liquid and the propylene tetrapolymer alkylated diphenylamine are compounded, so that the lubricating oil has excellent oxidation resistance and corrosion inhibition performance in mineral oil and synthetic oil, can reduce the friction coefficient of oil products, and is suitable for vehicle transmission oil, vehicle drive axles or electric transmissions, and the like. And the service condition requirement of long service life of a vehicle transmission system is met.

The invention discloses a preparation method of a sulfonimide compound and application of the sulfonimide compound in electrolyte, the preparation method comprises the following steps: in an organic solvent, in the presence of alkali, succinimide and alkyl sulfonyl chloride are subjected to a one-step reaction to obtain the sulfonimide compound, the reaction steps are simple, and the yield is high. When the sulfonyl imide compound is used as an additive to be applied to an electrolyte, the normal-temperature performance and the high-temperature performance of a battery can be improved at the same time.

The application discloses a preparation method of a semi-interpenetrating network hydrogel based on an amino-succinimide ring-opening reaction, which comprises the following steps: firstly, a hydrophilic compound containing amino groups, such as trishydroxymethylaminomethane, is used to modify polysuccinimide to obtain water-soluble polysuccinimide polymer; N-vinylcaprolactam and 3-mercaptopropionic acid are reacted to obtain poly-N-vinylcaprolactam polymer with terminal carboxyl groups; and the polymer is used to graft hydroxypropyl methyl cellulose to obtain macromolecular hydroxypropyl methyl cellulose derivative. The water-soluble polysuccinimide, the polymer containing amino groups and the hydroxypropyl methyl cellulose derivative are dissolved in water, and the amino-succinimide ring-opening reaction is utilized to obtain the hydrogel; the hydrogel is soaked in water to remove uncrosslinked components; and after drying, the semi-interpenetrating network hydrogel is obtained. The preparation process is simple, the conditions are mild, and the reaction speed is fast; and the prepared hydrogel has pH / temperature sensitivity and can be used in many fields such as tissue engineering, drug release, water treatment and the like.