43 results about "Succinimide" patented technology

The application discloses an anticoagulant biomaterial for blood purification and a preparation method and application thereof, and comprises the following steps: providing an amphiphilic copolymer P(AA-MMA); blending polyethersulfone, P(AA-MMA) and a solvent, stirring at a set temperature to obtain a casting solution, and preparing a blending membrane from the casting solution; soaking the blending membrane in a 2-morpholine-4-yl ethanesulfonic acid buffer solution containing argatroban, 1-ethyl-(3-dimethylaminopropyl) carbonyl diimide and hydroxy succinimide, and reacting at room temperature to obtain an argatroban grafted blending membrane, namely the anticoagulant biomaterial. The method improves the hydrophilicity of the membrane, reduces the albumin adsorption of the membrane, reduces the adhesion of platelets on the membrane, prolongs the coagulation time APTT, PT and TT of the membrane, and is better in biocompatibility and enhanced in anticoagulation performance.

This application discloses a chemiluminescence detection kit for acrylonitrile magnetic microparticles and its detection method. The kit includes a magnetic bead working solution and a luminescent label. The magnetic bead working solution includes acrylonitrile monoclonal antibody A and streptavidin. The luminescent label includes acrylonitrile monoclonal antibody B, modified nano-silica, anhydrous toluene, methoxy polyethylene glycol-succinimide ester, N,N-dimethylformamide, acrylonitrile succinimide ester, glutaraldehyde, and ethanolamine. This application uses modified nano-silica as a carrier and grafts a polyethylene glycol hydrophilic layer onto its surface, which amplifies the acrylonitrile ester molecule signal, reduces non-specific adsorption, and improves the sensitivity, specificity, and reliability of the detection.

This invention discloses a vascular bundle-targeted bio-selenium nanoparticle, its preparation method, and its application, belonging to the field of plant treatment technology. The invention involves mixing and dissolving bio-selenium nanoparticles, water, 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride, and N-hydroxysuccinimide, followed by activation to obtain an activated bio-selenium nanoparticle solution. A xylem-anchored peptide and MES buffer are then mixed and dissolved to obtain a xylem-anchored peptide solution. The activated bio-selenium nanoparticle solution and the xylem-anchored peptide solution are mixed, and the pH is adjusted to 6.3-6.8 before stirring to obtain the vascular bundle-targeted bio-selenium nanoparticle. The vascular bundle-targeted bio-selenium nanoparticle provided by this invention achieves interception of heavy metal transport pathways by specifically anchoring to xylem vessels. Compared with existing technologies that rely solely on broad-spectrum physiological antagonism, its efficiency in reducing heavy metal content in crop stems and leaves represents a qualitative leap.

This invention discloses an alkaline, phosphorus-free nano-chelating agent, which, by weight percentage, is composed of the following components: 30%–40% sodium hydroxide, 6%–15% polyethylene terephthalate, 5%–10% polyglutamic acid, 1%–5% polysuccinimide, 11%–18% ammonium citrate, 2%–9% nano-silica, 2%–9% nano-alumina, and the balance being water. This phosphorus-free nano-chelating agent contains no phosphorus and will not cause phosphorus pollution during use. Compared to traditional phosphorus-containing chemicals, it is more environmentally friendly and helps reduce phosphorus content in water bodies, thereby mitigating environmental problems such as eutrophication.

A preparation method and application of modified carboxymethyl cellulose belong to the technical field of environmental remediation and fixation. The present application solves the problems that the removal effect of the existing modified cellulose in soil remediation is poor, and the existing modification method of cellulose is carried out in a non-water organic solvent system, and the reaction time is long. Method: carboxymethyl cellulose is dissolved in pure water, then N-hydroxysuccinimide and melamine are dissolved in sequence, then EDC·HCl aqueous solution is added, stirring at room temperature, and finally washing and freeze-drying to obtain modified carboxymethyl cellulose; application: it is used for controlling soil mercury release. The present application is used for the preparation and application of modified carboxymethyl cellulose.

The application belongs to the field of pharmaceutical chemical industry, and particularly relates to a preparation method of a ticagrelor intermediate (1R, 2S)-2-(3, 4-difluorophenyl)cyclopropylamine, which comprises the following steps: taking compound II as raw material, and reacting with N-bromosuccinimide and sodium acetate to prepare target intermediate compound I. Compared with the prior art, the reaction has the advantages of mild reaction condition, simple operation, high safety, simple post-treatment, and safety and environmental protection. It is determined that the yield of the product prepared by the technical scheme disclosed in the application can reach more than 88%, and the purity is more than 99%.

The present application relates to the technical field of fertilizer, in particular to a general water-soluble fertilizer for agricultural planting and a preparation method thereof.The fertilizer is composed of a modified polyaspartic acid salt additive, a macroelement fertilizer and a trace element fertilizer.The additive is obtained by alkaline hydrolysis after the reaction of polysuccinimide with 3-amino-1,2-propanediol, boric acid, sodium tetraborate decahydrate and potassium taurate in sequence.The process of first preparing a pre-dispersion of the additive and trace elements and then mixing with macroelements can improve the solubility stability of the fertilizer in high-hardness water and increase the soluble retention rate of iron and zinc, and is suitable for integrated water and fertilizer application.

The application provides a colorimetric-fluorescent dual-mode determination method for hydrophobic anticancer drug curcumin, and the application realizes the preparation of oil amine branch joint polysuccinimide loaded curcumin (CUR@PSI OAm ) coated antigen, dual-mode probe labeled anti-PSI OAm antibody, and specific combination of antigen-antibody reaction for dual-mode ultra-trace detection and analysis of CUR@PSI OAm in cells, and indirect quantitative detection of hydrophobic anticancer drug curcumin in cells. Compared with the prior art, the dual-mode analysis method provided by the application can be mutually supported, and does not need to be enriched and preprocessed, is simple to operate, has short detection time, has the characteristics of high throughput, high sensitivity, high specificity, precise targeting and non-destructive detection, and can be used for ultra-trace non-destructive detection and analysis of hydrophobic anticancer drug curcumin (CUR) in cells.

The application discloses a bipolar polymer semiconductor material containing difluoro-substituted indathrene and a preparation method and application thereof. N The copolymerization of the obtained copolymer monomer and 5,5'- (bistrimethyltinyl) -2,2'-dithiophene or (E) -1,2- (5- (bistrimethyltinyl) -thiophene-2-yl) ethylene, a centrosymmetric monomer, through a bromination reaction of bromo-succinimide to obtain a novel bipolar polymer semiconductor material containing difluoro-substituted indathrene with a D-A configuration. The synthesis route of the application is simple and efficient, raw materials are easy to obtain, the cost is low, the universality is high, and the repeatability is good. The material has the advantages of good solubility, excellent thermal stability and strong absorption spectrum range. The bipolar polymer semiconductor material prepared by the application is used as an active layer material, and an organic field effect transistor device prepared by the application has excellent electrical performance. The material has broad commercial prospects in organic thermoelectricity, organic field effect transistors, organic logic complementary circuits and other optoelectronic devices.

This invention discloses a berberine-dimethylaniline photosensitizer, its preparation method, and its application, belonging to the field of biomedical technology. The method involves sequentially reacting berberine with magnesium methyl bromide via Grignard addition, followed by bromomethylation with N-bromosuccinimide, and basic condensation with dimethylaminobenzaldehyde, then demethylating under high temperature and vacuum to obtain the active berberine-dimethylaniline. Finally, it undergoes weakly alkaline treatment to obtain the inactivated berberine-dimethylaniline. This invention introduces the electron-donating group dimethylaniline onto the berberine backbone, constructing an electron push-pull structure that red-shifts the absorption wavelength, facilitating deeper tissue penetration. Furthermore, this photosensitizer maintains high activity in the weakly acidic microenvironment of tumors while remaining inactive under normal physiological conditions, thereby achieving intelligent "on-off" regulation based on pH differences, improving the safety and precision of photodynamic therapy for tumors.

Succinimide-based compounds used in compositions and methods for inhibiting natural gas hydrate agglomerates are disclosed. These compounds are reaction products of an alkenylsuccinic anhydride and an amine or amine alcohol.

The application discloses an oilfield corrosion and scale inhibitor and a preparation method thereof, and relates to the technical field of corrosion and scale inhibitors. In the preparation of the oilfield corrosion and scale inhibitor, modified polyaspartic acid is prepared by reacting poly succinimide with 3,5-diamino salicylic acid and p-aminobenzenesulfonic acid; and the oilfield corrosion and scale inhibitor is prepared by reacting the modified polyaspartic acid, hydroxypropyltrimethylammonium chloride chitosan and 2,5-thiophenedicarboxaldehyde. The oilfield corrosion and scale inhibitor prepared by the application has good corrosion and scale inhibition performance.

The present disclosure provides a method for preparing Fmoc-Lys(Ivdde)-OH, comprising steps of: reacting dimedone with isovaleric acid in the presence of a condensing agent to obtain an intermediate compound; then reacting the intermediate compound with N-alpha-tert-butoxycarbonyl-L-Lysine in the presence of an organic base to obtain an intermediate; then reacting the intermediate with an acid to obtain another intermediate; and finally reacting the another intermediate with N-(9-fluorenylmethoxycarbonyloxy)succinimide in the presence of an inorganic base to obtain Fmoc-Lys(Ivdde)-OH. The method simplifies the process, features simple operations and mild reaction conditions, and reduces the difficulty of industrial production. Furthermore, the method does not involve expensive raw materials, which is beneficial for controlling production costs, and a product is obtained with a high purity and a high yield.

This application discloses an injectable wet-adhesive hydrogel, its preparation method, and its application, belonging to the field of biomedical materials technology. The hydrogel of this application is formed by in-situ covalent cross-linking of liquid component A and liquid component B. Liquid component A contains an aqueous solution of a four-arm polyethylene glycol succinimide ester compound; liquid component B contains an aqueous solution of serum albumin and an amino-containing biomedical polymer additive. Depending on the amino-containing biomedical polymer additive, the hydrogel has two composition schemes: one is a quaternary structure of a four-arm polyethylene glycol succinimide ester compound, serum albumin, polylysine, and sodium alginate; the other is a ternary structure of a four-arm polyethylene glycol succinimide ester compound, serum albumin, and a four-arm polyethylene glycol amine. This hydrogel possesses good injectability and low swelling rate, and can construct a multi-point covalent cross-linking mechanism combining chemical cross-linking and reversible physical cross-linking, significantly improving the wet adhesion performance and mechanical stability of the hydrogel, effectively achieving a long-term stable sealing effect during dynamic tissue activity in vivo.

The present invention provides a crystalline form of (2R,3S)—N-((3S)-5-(3-fluorophenyl)-9-methyl-2-oxo-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-2,3-bis(3,3,3-trifluoropropyl)succinimide, represented by the structure of Compound 1:wherein the crystalline form comprises N-2 crystalline form, IPA2-1 crystalline form, M3-1 crystalline form, P4 crystalline form, P5 crystalline form, P6 crystalline form, or any combination thereof. The present invention also provides processes for the preparation of a the crystalline form, and pharmaceutical compositions comprising one or more of the crystalline forms.

This invention proposes a polyaspartic acid chelated zinc and its preparation method, belonging to the technical field of polyaspartic acid materials. The preparation method of the polyaspartic acid chelated zinc includes: polymerizing L-aspartic acid under a phosphoric acid catalyst to obtain a polysuccinimide intermediate; and mixing the polysuccinimide intermediate with... α‑ After undergoing a ring-opening grafting reaction with amino acids and aminolated oligosaccharides, polyaspartic acid derivatives are obtained. The polyaspartic acid derivatives are then chelated with zinc salts to obtain the polyaspartic acid chelated zinc. This invention obtains polyaspartic acid chelated zinc by grafting α-amino acids and aminolated oligosaccharides onto polyaspartic acid molecules as modifiers followed by zinc chelation. Compared to ordinary polyaspartic acid zinc, it has a higher molecular weight and stronger chelating functional groups, thus enabling effective chelation of zinc ions. When used as a fertilizer synergist, it can effectively improve crop yield and quality.

The present invention relates to an electrospun multilayer tube or wrap for the protection or bridging of damaged nerves, comprising an electrospun isolating outer layer and at least one electrospun inner layer, the electrospun isolating outer layer comprising at least one polymer selected from the group consisting of polycaprolactone, polylactide, polyglycolide, polytrimethylene carbonate, polydioxanone, polyethylene glycol, polyurethane, copolymers thereof or mixtures thereof, the at least one electrospun inner layer comprising an agent capable of forming a covalent bond with proteins and peptides, the agent comprising at least one group selected from the group consisting of N-hydroxysuccinimide, maleimide, thio-NHS, biotin-NHS, carboxylic acid or aldehyde. Furthermore, the present invention relates to a method of manufacturing such a tube or wrap and to their use for the protection or bridging of nerves or for stimulating nerve growth and cell proliferation.

The present application relates to the field of heterocyclic synthesis and the field of organic photocatalysis, in particular to a preparation method and application of pyrrolo [3,4-c] pyrrole-1,3(2H,5H)-dione derivatives. The present application realizes one-step synthesis of a new photocatalyst, pyrrolo [3,4-c] pyrrole-1,3(2H,5H)-dione derivatives, from tetrahydroisoquinoline and methylene succinimide compounds under catalysis of elemental iodine in an air atmosphere. The technical scheme has the following advantages: (1) the required reagent is stable in nature, does not need pretreatment, is cheap and easy to obtain; (2) one-pot synthesis, obvious economic advantage in steps, no need for water-free and oxygen-free operation, time and labor saving; (3) the molecule itself does not contain metal elements, and no transition metal catalyst is needed, which fundamentally eliminates the problem of metal residues; (4) the use of cheap elemental iodine catalysis reduces environmental pollution and saves reaction cost; (5) the series of derivatives all have suitable oxidation-reduction potentials, and can be used as photocatalysts to catalyze multiple reactions; (5) as a catalyst, the catalytic efficiency is high, and only 0.5-1% loading is needed to catalyze the reaction.

The application provides a lubricating antirust oil and a preparation method and application thereof, and the lubricating antirust oil comprises the following components in parts by weight: base oil 55-80 parts by weight, antirust agent 5-10 parts by weight, antioxidant 2-5 parts by weight, film forming agent 1-3 parts by weight and lubricating additive 5-10 parts by weight; the lubricating additive is prepared by mixing phosphate amine salt, bis-alkenyl succinimide, hexagonal boron nitride and modified metal complex; the modified metal complex is obtained by reacting 2,5-dihydroxybenzoic acid with a metal salt and then modifying the obtained product by using a long-chain alkane modifier. The lubricating antirust oil provided by the application can realize multiple effects of antirust and lubrication simultaneously.

The present application relates to the technical field of biology, in particular to a method for synthesizing a pregabalin intermediate by using immobilized hydantoinase. The pregabalin intermediate with an optical purity of more than 99.9% is obtained by catalyzing the reaction of a substrate 3-isobutyl succinimide under the action of immobilized enzyme; wherein the amino acid sequence of the immobilized enzyme is shown in SEQ ID No. 1. The present application is immobilized by using specific enzyme under specific conditions, and the stability and purity of the enzyme are improved after the treatment, the optical purity of the product is more than 99.9%, and 50 batches of stable application are realized.

The application belongs to the technical field of carbon materials, and specifically provides a phenolic resin-based spherical carbon material and a preparation method thereof, the preparation method comprising the following steps: 1) subjecting alpha-lipoic acid, N-hydroxysuccinimide and N,N'-dicyclohexyl carbodiimide to an activation reaction in a solvent, adding 2-(dimethylamino)ethyl methacrylate to the filtrate after filtration to perform a reaction, then adding 1,4-butane sultone to perform a reaction, and obtaining a betaine derivative through post-treatment; 2) mixing phenol, the betaine derivative, an aqueous formaldehyde solution, polyethylene glycol and ammonia water to perform a polymerization reaction, then adding hexamethylenetetramine to perform a cross-linking and curing reaction, performing solid-liquid separation, washing and drying after the reaction is completed to obtain a precursor, and performing high-temperature carbonization treatment on the precursor under an inert atmosphere, so that the phenolic resin-based spherical carbon material is obtained after cooling. The carbon material prepared by the application has the advantages of good sphericity, perfect pore structure, uniform particle size and high specific surface area.

The application belongs to the technical field of silica preparation, and specifically provides a production process of high-purity nano-silica, which comprises the following steps: taking quartz sand for acid immersion, then reacting with hydrofluoric acid to obtain a fluosilicic acid solution, adding concentrated sulfuric acid to the fluosilicic acid solution to prepare silicon tetrafluoride gas, and then performing hydrolysis, filtration, washing, drying and calcination on the silicon tetrafluoride gas to obtain high-purity nano-silica; a dispersing agent is added in the hydrolysis process; the preparation raw materials of the dispersing agent used in the application include maltose and N-hydroxysuccinimide. The nano-silica prepared by the application has a higher specific surface area and purity, and a smaller and more uniform particle size.

This invention discloses a thermoformable composite sheet and its preparation method, comprising, by weight: 40-60 parts high-density polyethylene, 10-25 parts metallocene polyethylene, 20-40 parts modified cyclic olefin copolymer, 10-20 parts inorganic filler, and 0.2-2 parts latent crosslinking agent; wherein, the modified cyclic olefin copolymer is obtained by modifying some cyclic olefin units on the cyclic olefin copolymer molecular chain with N and / or O-containing heterocyclic side groups, wherein the heterocyclic side groups are selected from one or more of oxazoline, oxazolidinone, triazolone, hydantoin, or succinimide. In preparation, the cyclic olefin copolymer is first melt-grafted with a heterocyclic modifying agent to obtain the modified cyclic olefin copolymer, then dry-premixed with the remaining components, melt-blended, extruded and cast, and finally activated at high temperature to induce crosslinking by the latent crosslinking agent. This invention controls the glass transition temperature of the cyclic olefin copolymer through heterocyclic modification, achieving high barrier properties while maintaining a wide thermoforming window.

This invention provides a self-adhesive biological patch, its preparation method, and its uses. The self-adhesive biological patch of this invention comprises: a substrate having a fibrous structure; and an adhesive coating present on at least one surface of the substrate, the adhesive coating comprising a first layer and a second layer, wherein the first layer is made from polyethylene glycol succinimide glutarate and natural plant extracts, and the second layer is made from polyethylene glycol amine; furthermore, the first and second layers are cross-linked under wetting conditions to form a cross-linked network structure, thereby loading at least a portion of the natural plant extracts within the cross-linked network structure. The self-adhesive biological patch of this invention can firmly adhere to tissue surfaces and can be applied directly without additional preparation, avoiding damage to surrounding normal tissue caused by additional sutures or staples.

The application discloses a kind of low viscosity non-toxic silane end-capped polyether resin and preparation method thereof, belong to sealant technical field.The preparation method of the silane end-capped polyether resin is with succinic anhydride and polyether polyol as raw material, polymer is prepared under the catalysis of acid catalyst;N-hydroxysuccinimide and carbodiimide catalyst are added to polymer and stirred to react, end-capping is carried out by dropping aminoalkoxy silane coupling agent to system, and the silane end-capped polyether resin is prepared.The application is reacted with polyether polyol by cheap succinic anhydride, the hydroxyl group at the end of polyether alcohol is changed into more active carboxyl group while chain extension, subsequent modification is facilitated, expensive and toxic isocyanate coupling agent or tin catalyst is not introduced, it is safe and non-toxic, the silane end-capped resin obtained only contains two amide bonds at the end, can effectively reduce the viscosity of product, and be beneficial to subsequent application of product.

The application discloses a graft copolymerization modified high-water-retention formaldehyde-free adhesive and a preparation method and application thereof, and belongs to the technical field of adhesive preparation. The adhesive is composed of the following components: deionized water, plant protein meal powder, cationic polyamide polyamine epichlorohydrin resin and anionic moisturizing factor. The anionic moisturizing factor is prepared from the following components: deionized water, an initiator, acrylamide, itaconic acid, chitosan, hydrochloric acid, N,N'-methylene bisacrylamide, 1-ethyl-(3-dimethylaminopropyl) carbonyldiimidazole hydrochloride and N-hydroxy succinimide. In the graft copolymerization reaction of acrylamide, itaconic acid and chitosan, the negatively charged moisturizing factor is formed in situ, and is used in combination with the positively charged polyamide polyamine resin. The water-retention performance of the plant protein adhesive is significantly improved, and the mechanical strength characteristics are simultaneously enhanced.