37 results about "Methyl trifluoromethanesulfonate" patented technology

The invention relates to a preparation method of sulfonyl azide compounds, which comprises the following steps: (a) reacting compounds disclosed as Formula (II) with methyl trifluoromethanesulfonate to obtain compounds disclosed as Formula (III), wherein the compounds disclosed as Formula (II) are compounds disclosed as Formula (II-1) or Formula (II-2), and the compounds disclosed as Formula (III) are compounds disclosed as Formula (III-1) or Formula (III-2); and (b) reacting the compounds disclosed as Formula (III) obtained in the step (a) with sodium azide to obtain sulfonyl azide compounds disclosed as Formula (I), wherein the sulfonyl azide compounds disclosed as Formula (I) are compounds disclosed as Formula (I-1) or Formula (I-2). The whole technical process has the advantages of mild conditions, high yield and high repetitiveness, is simple to operate, is safe and controllable, and can easily implement industrial production.

Disclosed is a meta-position alkylphenol synthesizing method. The meta-position alkylphenol synthesizing method is obtained through direct reaction of 2-(3-alkyl-phenoxy) pyridine and methyl trifluoromethansulfonate. The method comprises a reaction process of directly adding the 2-(3-alkyl-phenoxy) pyridine, the methyl trifluoromethansulfonate and methylbenzene into a reaction device; in a nitrogen atmosphere, performing stirring at 100 DEG C for reaction for 24 hours, and after the reaction is completed, separating out coarse products; adding the coarse products and sodium into methyl alcohol for refluxing for 15 minutes, and then performing separation to obtain meta-position alkylphenol compounds. The meta-position alkylphenol synthesizing method is reliable in raw material source and simple in reaction and is an economic and efficient meta-position alkylphenol preparing method.

The invention discloses a preparation method of a 5-arylsulfonyl-2-chlorophenol compound, which is prepared from a 2-(5-arylsulfonyl-2-chlorophenoxy) pyridine compound as a raw material by the following steps: A: directly adding the 2-(5-arylsulfonyl-2-chlorophenoxy) pyridine compound, methyl trifluoromethansulfonate and toluene into a reacting device, stirring for reacting for 24 hours at 100 DEG C, and then separating a crude product; and B: adding the crude product obtained in the step A to methanol, adding sodium, refluxing for 15 minutes, and separating to obtain the 5-arylsulfonyl-2-chlorophenol compound. The preparation method is simple and mild in reaction conditions, is finished in one step, and can be well applied to preparation of the 5-arylsulfonyl-2-chlorophenol compound.

The invention relates to a circulation improvement type lithium and manganese-rich solid solution batteryincluding a positive electrode, a negative electrode and an electrolyte, wherein the positive electrode comprises a positive electrode active material, a positive electrode conductive agent and a positive electrode binder, the negative electrode includes a negative electrode active material, a negative electrode binder and a negative electrode conductive agent, and the circulation improvement type lithium and manganese-rich solid solution batteryis characterized in that, the electrolyte includes a lithium salt, an organic solvent, a film forming additive, a stabilizer and auxiliaries; the and the auxiliary are methyl trifluoromethansulfonate and 4, 4 '-sulfonyl diphenylamine. The invention provides a circulation improvement type lithium and manganese-rich solid solution batterywhich has the advantages of low cost and high capacity, and on the premise of satisfying the multiplying power performance and high and low temperature performance of a normal lithium and manganese-rich solid solution lithium ion battery, the circulation life of the battery system is obviously increased.

The invention belongs to the field of antitumor drug preparation, in particular to a 1-methyl-7H-indene[1, 2-b]quinolinetrifluoromesylate-7-(4-dimethylamino)benzyl alkene derivant used as a DNA topoisomerase inhibitor and a preparation method thereof. The preparation method comprises the following steps of: (1) salification reaction: reacting 7H-indene [1, 2-b]quinoline with methyl trifluoromethanesulfonate in the molar ratio of 1 to (2-3) under the protection of nitrogen gas at room temperature with stirring to obtain 7H-indene[1, 2-b]quinolinetrifluoromesylate; (2) coupling reaction: reacting the obtain 7H-indene[1, 2-b]quinolinetrifluoromesylate and 4-dimethylaminobenzaldehyde in the molar ratio of 1.0:(1.4-1.6) in glacial acetic acid in refluxing to prepare the 1-methyl-7H-indene[1, 2-b]quinolinetrifluoromesylate-7-(4-dimethylamino)benzyl alkene derivant. The prepared compound has strong inhibition action on leukemia cells and human laryngeal squamous carcinoma cells; moreover, the preparation method has the advantages of simple process and good yield reaching about 65%.

The invention belongs to the field of anti-tumor medicine preparation and in particularly relates to a 1-methyl-5H-indene (1,2-b) pyridine trifluoromethanesulfonic salt-5-(4-dimethylamino group) benzylidene derivative used as a DNA topoisomerase inhibitor and a preparation method thereof. The preparation method comprises the following steps of: (1) salifying reaction: stirring and reacting 5H-indene (1,2-b) pyridine and trifluoromethanesulfonic methyl ester in the molar ratio of 1:2-3 under the nitrogen protection at room temperature to obtain 1-methyl-5H-indene (1,2-b) pyridine trifluoromethanesulfonic salt; and (2) coupling reaction: distilling the 1-methyl-5H-indene (1,2-b) pyridine trifluoromethanesulfonic salt obtained in the step (1) with 4-dimethylaminobenzaldehyde in the molar ratio of 1.0:1.4-1.6 in glacial acetic acid to obtain the 1-methyl-5H-indene (1,2-b) pyridine trifluoromethanesulfonic salt-5-(4-dimethylamino group) benzylidene derivative. The obtained compound has strong function for inhibiting leukemia cell and human laryngeal squamous carcinoma. Besides, the preparation method has simple process and good productivity as high as about 65%.

The invention discloses a method for improving thermal stability of liquid fructosaminase. The method comprises the following steps: 1) preparing a tris(hydroxymethyl) aminomethane-hydrochloric acid buffer solution comprising fructosaminase and sodium azide and having a pH value of 7.5-8.5; 2) under a low-temperature stirring condition, adding 1-butyl sulfonate-3-methyl trifluoromethanesulfonate, trehalose and TritonX-100 into the buffering solution prepared in the step (1). With adoption of the method disclosed by the invention, the thermal stability of the fructosaminase is obviously improved, and the fructosaminase can be applied to develop a determination reagent for glycated albumin determined by an FAOD (fructosaminase) clearance method; the method for improving thermal stability of liquid fructosaminase cannot interfere GA content determination by the FAOD clearance method, can obviously improve the thermal stability of the liquid for fructosaminase, enables the liquid fructosaminase to be still enough in activity 12 months after preservation at the temperature of 4 DEG C.