55 results about "Chiral phase" patented technology

Disclosed are liquid crystal (LC) phase-retarders and linear polarizers and methods and apparatus for making the same. The liquid crystal phase-retarder is realized by a liquid crystal film structure having one or more phase retardation regions formed therein. Each phase retardation region has an optical axis specified by the direction and depth of orientation of liquid crystal molecules along the surface of the liquid crystal film structure. The liquid crystal linear polarizer is realized by a liquid crystal film structure having a chiral phase region within which liquid crystal molecules are cholesterically ordered. One or more nematic phase regions are formed along the surface of the liquid crystal film structure within which liquid crystal molecules are oriented along a direction and to a surface depth sufficient to realize one or more phase retardation regions therein having optical axes along the direction of liquid crystal molecule orientation.

The present invention provides a compound of the following formula (I) below. This compound (I) can be produced by reacting a 2,2′-dimethylene bromide-1,1′-binaphthyl derivative, which can be produced by a relatively small number of processes, with an easily available secondary amine. This compound (I) is useful as a chiral phase-transfer catalyst.

The invention belongs to the technical fields of organic synthesis and provides a novel method for asymmetric alpha-hydroxylation of a photo-oxygenation beta-dicarbonyl compound based on a C-2' phase transfer catalyst.The beta-dicarbonyl compound, the cinchona alkaloid C-2' phase transfer catalyst and an organic photosensitizer are stirred in a solvent, alkali is added, strong stirring reaction is performed in the air under the condition of visible light, the reaction temperature is 50-70 DEG C, the reaction time is 1-4 hours, and a chiral alpha-hydroxyl-beta-dicarbonyl compound with the yield no lower than 70% and the enantiomeric excess selectivity no lower than 60% ee is obtained; derivatization is conducted on a cheap cinchona alkaloid C-2' potential easy to obtain a series of chiral phase transfer catalysts having higher catalytic activity, molecules are successively oxidized into an oxidant, and the asymmetric alpha-hydroxylation of the photo-oxygenation beta-dicarbonyl compound is achieved.The method has good substrate applicability and environmental friendliness.

The invention discloses a COF-coated MOF/M/L composite material, which comprises a COF-coated MOF material with a core-shell structure synthesized by a COF-coated MOF crystal material, the MOF of the COF-coated MOF material is firstly subjected to synthesis, then is subjected to metal ion exchange, and then is subjected to ligand exchange to form the COF-coated MOF/M/L composite material with metal ions and chiral ligands. Meanwhile, the invention discloses a preparation method of the COF-coatedMOF/M/L composite material. The COF-coated MOF/M/L composite material disclosed by the invention has the characteristics of a COF-coated MOF material with a core-shell structure; meanwhile, metal ions such as copper or iron with an efficient catalytic degradation function and chiral functional organic ligands such as Llactic acid or histidine are introduced, so that nodes of the MOF have high catalytic activity of monatomic catalysis, and chiral toxic pollutants such as cis-permethrin and cis-permethrin are effectively identified by utilizing chiral-chiral interaction; chiral pollutants can be selectively, quickly, efficiently and thoroughly catalytically degraded into non-toxic substances.

The present invention provides a chiral phase-transfer catalyst of the following formula (I):

The compound (I) can be produced by reacting a 2,2′-dimethylene bromide-1,1′-biphenyl derivative, which can be produced through comparatively small number of steps, with an easily available secondary amine.

The synthesis process 6-18F-L-Dopa (18FDOPA) with 6-nitro piperonaldehyde as precursor includes four steps: nucleophilic fluorination, reducing bromination, chiral phase transferring catalytic alkylation and hydrolysis. The process has high production efficiency, no need of purifying precursor, easy to purify final product, and low cost. The product may be used in animal experiment and conventional clinical application.

The present invention relates to enantiomeric forms of hepoxilin analogs of Formula I-VIII, pharmaceutical compositions thereof, a method for the separation of said enantiomeric forms of hepoxilin analogs comprising applying said hepoxilin to a chiral phase HPLC column and eluting said hepoxilin with an alkane and alcohol solvent mixture. Said enantiomeric forms of hepoxilin analogs of Formula I-VIII were found to be useful in controlling the biological effects of PPAR mediated transcriptional control for the treatment of diseases such as cancer, thromboxane-mediated diseases and for modulating intracellular calcium concentration.

The invention relates to optically active ilaprazole and a synthesis method thereof, belongs to the field of pharmaceutical technology, and discloses a method for synthesizing optically active ilaprazole. According to the method, corresponding thiol is used as a starting raw material, and reacts with acrylate or halopropionate to obtain a thioether compound, the thioether compound is oxidized to obtain racemic sulfoxide, and the racemic sulfoxide reacts with another fragment under the action of a chiral phase transfer catalyst to obtain the chiral ilaprazole. According to the present invention, the preparation of the chiral ilaprazole is firstly reported, the synthesis method of the chiral ilaprazole does not require the use of heavy metals and the use of dangerous peroxides, and the excessive oxidation by-product is generated at the penultimate chemical step so as to easily control; and the method has characteristics of novel process, few steps, mild reaction conditions and the like.

The invention discloses a chiral phase transfer catalyst and a synthesizing method thereof, which relate to chemical synthesis and in particular relates to the technical field of synthesis of the novel chiral phase transfer catalyst. The method comprises the following steps of dissolving quinine in solvent, reacting with sodium hydride, reacting by adding hydrocarbon dihalide, extracting to obtain an organic layer, drying, and re-separating for removing the solvent so as to obtain the chiral phase transfer catalyst. The chiral phase transfer catalyst is novel in structure, and central nitrogen-atoms of the chiral phase transfer catalyst has good hidden performance, and therefore, the chiral phase transfer catalyst has certain special catalyzing effects, and can be suitable for requirements of catalytic reactions with various types. The chiral phase transfer catalyst prepared by the method can be applied to tert-Butyl glycinate ramification asymmetrical alkylating reaction, achieves excellent results, and is an excellent chiral phase transfer catalyst proved by practices.

The invention discloses a stereoselectivity preparation method for a compound shown in the formula (I). First, chiral phase-transfer catalysts of quaternary ammonium salts are employed to catalyze a stereoselective Darzen reaction of diphenyl ketone and alpha-halogenated acetic ester, and optically pure epoxides are obtained. Then ring opening, nucleophilic substitution and ester group hydrolysis reaction are carried out in order and optically pure Letairis is obtained. The method is aimed to achieve industrial preparation of optically pure Letairis. By utilization of the stereoselectivity preparation method, generation of another isomer is avoided, the yield of the target compound is increased, and the method accords with requirements of green synthesis.

The present invention relates to a novel stationary phase support for liquid chromatographic chiral separations. The specific combination of the special underlying support material and certain classes of known chiral selectors according to the invention produces far superior chiral (enantiomeric) separations than those obtained on any conventionally known supports. These chiral (enantiomeric) separations are enhanced in terms of significantly higher efficiencies (theoretical plate numbers), higher resolutions (R_s), shorter retention times and either equivalent or slightly higher selectivities than those obtained on conventional supports.

A process for synthesizing the simple optical isomer nitrendipine features that under existance of quinine-ammonium benzylbromide as chiral phase-transfer catalyst, 2-(3-nitrobenzilidene) ethyl acetylacetate and beta-methyl amino crotonate take part in stereoselective condensating reaction in absolute alcohol to obtain target product.

The invention provides novel optically active dibenzazepine derivatives having high utility value as chiral phase-transfer catalyst, more specifically, optically active 6,7-dihydro-5H-dibenz-[c,e]azepine derivatives represented by general formula (1') [wherein R is a divalent organic bridging group for joining the 1- and 11-positions; R1 and R2 may be the same or different and are each hydrogen, halogeno, or an organic group, or R1 and R2 may together represent an divalent organic group; R3' and R4' may be the same or different and are each a monovalent organic group, or R3' and R4' may together represent a cyclic organic group containing the onium nitrogen atom; Ar is a monovalent organic group; * represents optical activity, that is, an excess of one axially chiral isomer over the other axially chiral isomer, both isomers being due to the bond axis constituting the biphenyl structure of the derivative; and X- is a counter anion].

Disclosed are liquid crystal (LC) phase-retarders and linear polarizers and methods and apparatus for making the same. The liquid crystal phase-retarder is realized by a liquid crystal film structure having one or more phase retardation regions formed therein. Each phase retardation region has an optical axis specified by the direction and depth of orientation of liquid crystal molecules along the surface of the liquid crystal film structure. The liquid crystal linear polarizer is realized by a liquid crystal film structure having a chiral phase region within which liquid crystal molecules are cholesterically ordered. One or more nematic phase regions are formed along the surface of the liquid crystal film structure within which liquid crystal molecules are oriented along a direction and to a surface depth sufficient to realize one or more phase retardation regions therein having optical axes along the direction of liquid crystal molecule orientation.

The invention relates to a method for preparing an intermediate of ecteinascidin-743 and particularly relates to a method for preparing an intermediate which is used for synthesizing ecteinascidin-743 and is represented by the formula I as shown in the description. The method comprises the following steps of carrying out protecting group conversion on a compound represented by the formula X as shown in the description in the presence of a chiral phase transfer catalyst to obtain a chiral intermediate represented by the formula V as shown in the description, carrying out esterification reaction on the intermediate V to obtain an intermediate represented by the formula IV as shown in the description and then carrying out intramolecular cyclization reaction and removing the protecting groups to obtain the intermediate which is used for synthesizing ecteinascidin-743 and is represented by the formula I. The method has the advantages of mild reaction conditions, simplicity in operation, low synthesis cost and the like and is suitable for mass production.