185 results about "Nucleophile" patented technology

The invention provides a halohydrin dehalogenase mutant and an application of the halohydrin dehalogenase mutant in synthesis of a chiral gamma-amino alcohol compound. Halogenated alcohol dehalogenase mutants enabling 2-substituted oxetane to be subjected to ring opening are obtained through the technologies of gene mining, directed evolution and the like, and the enzymes can directly perform ring opening on a substrate 2-aryl oxetane under the action of a nucleophilic reagent to generate a series of chiral gamma-amino alcohol compounds which are important precursors for synthesizing drugs. Therefore, the halohydrin dehalogenase mutants have important application value in the industry.

The invention discloses a dechlorination regeneration method of a chlorine poisoning noble metal catalyst and an application of the regenerated noble metal catalyst in polyolefin hydrogenolysis, and the dechlorination regeneration method comprises the following steps: dispersing the chlorine poisoning noble metal catalyst in water, adding a strong nucleophilic reagent for treatment, and carrying out centrifugal separation, washing and drying treatment to obtain the chlorine poisoning noble metal catalyst. The regenerated noble metal catalyst is obtained. A strong nucleophilic reagent dechlorination regeneration strategy under a room temperature mild condition is provided, chemically inert metal-chlorine bonds are broken through a nucleophilic substitution effect, noble metal particles are prevented from being agglomerated and sintered while deep dechlorination is realized, polyolefin hydrogenolysis activity of the catalyst can be completely recovered, activity improvement can be realized, and the catalyst has a good application prospect. Meanwhile, the regeneration cost is greatly reduced, and the regenerated noble metal catalyst can be used for efficiently hydrogenolyzing, upgrading and recycling waste polyolefin to obtain liquid alkane fuel with high additional value.

This invention belongs to the field of chemical synthesis and relates to a method for achieving deuterated methylation of a nucleophile. The invention provides a deuterated methylating reagent, which is obtained by reacting formic acid with deuterated methanol under acidic conditions, followed by a second reaction with thiaanthracite and trifluoromethanesulfonic acid. The nucleophile is then reacted with the deuterated methylating reagent described in claim 1, a base, and a solvent to obtain the deuterated methylated product. This invention also provides a method for achieving deuterated methylation of a nucleophile, which involves dissolving the nucleophile and 5-deuterated methyl-5H-thiophene-5-onium trifluoromethanesulfonate in a suitable solvent, adding a base, and then performing the deuterated methylation reaction at room temperature. In the method provided by this invention, the yield of the product after nucleophile methylation can reach 52% to 95%.

The invention relates to the technical field of organic dyes, in particular to a novel xanthene dye for blue photoresist color paste and a synthesis method of the novel xanthene dye. The invention relates to a synthesis method of a novel xanthene dye for blue photoresist color paste, which comprises the following steps: 1) taking rigid cyclic amine as a nucleophilic reagent, and carrying out aromatic nucleophilic substitution reaction on a chlorinated xanthene compound to obtain a xanthene intermediate; 2) performing chlorination reaction on the xanthene intermediate by using a chlorination reagent to obtain a chlorinated xanthene intermediate; 3) mixing active amine and the chlorinated xanthene intermediate, and performing substitution reaction under the action of alkali to obtain the novel xanthene dye for the blue photoresist color paste.The novel xanthene dye for the blue photoresist color paste.The novel xanthene dye for the blue photoresist color paste.The novel xanthene dye for the blue photoresist color paste.The novel xanthene dye for the blue photoresist color paste has the advantages of being high in solubility, good in thermal stability and high in contrast ratio.

Partially oxidized carbonaceous materials characterized by substantially homogenous, partially oxygenated surfaces thereof are enabled via microwave-assisted methods that are simple and fast. The exemplary methods include combining carbonaceous material(s), at least one mild oxidizer, at least one nucleophile, and an aqueous solvent system to obtain a mixture; and exposing the mixture to microwave radiation for a predetermined time to produce partially oxidized carbonaceous materials. The predetermined time may be in a range from about 5 seconds to about 2 hours, and the power of the microwave energy may be in a range from about 100 w to about 1700 W. The partially oxidized carbonaceous materials are characterized by a homogeneous distribution of oxygen content in surfaces thereof, in nonzero amounts up to about 10 at %, and a standard deviation of surface oxygen content in a range from about 0.1 at % to about 1.0 at %.

The invention relates to a gel electrolyte and a preparation method and application thereof. The gel electrolyte is prepared from the following raw materials: a nitrogen heterocyclic gel monomer, an electrolyte and an initiator, the nitrogen heterocyclic gel monomer is prepared from the following raw materials: a nucleophilic reagent and an epoxy compound. The gel electrolyte provided by the invention is high in conductivity and good in uniformity, can realize stable circulation under 5C multiplying power, and can be well applied to a quick-charge type gel battery.

The present invention provides a microcapsule composition comprising at least one core-shell microcapsule, wherein the at least one core-shell microcapsule comprises a core comprising at least one benefit agent and a shell surrounding the core, wherein the shell comprises a resin formed by the reaction of: 5 - a Michael acceptor which is the reaction product of a biodegradable polyester polyol with an α,β-unsaturated acid chloride; and - a Michael donor comprising at least two nucleophilic moieties selected from the group consisting of a nitrogen nucleophile, a sulfur nucleophile, an oxygen nucleophile, a carbon nucleophile, a phosphorus nucleophile, and mixtures thereof, which are capable to react with the 10 acrylic double bond of the Michael acceptor. The invention also relates to consumer products comprising the microcapsule composition, a method for preparing the microcapsule composition and to the use of the microcapsule composition to enhance the performance of a benefit agent in a consumer product.

The invention discloses a method for synthesizing a sulfur-containing compound by using an amino sulfur trifluoride compound, which comprises the following two steps: S1, by taking the amino sulfur trifluoride compound and a compound A as reactants, stirring and reacting for 8-15 minutes or 10-15 hours at normal temperature in an organic solvent under an alkaline condition; the compound A is any one of an amide compound or a sulfanilamide compound, or water; and S2, adding a nucleophilic reagent into the solution after the reaction in the step S1, stirring at normal temperature to react for 8-15 minutes or 5-8 hours, and then purifying through a rapid chromatography to obtain a final product, namely, all-heteroatom substituted thioimine or all-heteroatom substituted sulfoxide, the nucleophilic reagent is an alcohol or an amine. According to the method disclosed by the invention, the amido sulfur trifluoride compound is used for synthesizing the asymmetric full heteroatom substituted thioimine and sulfoxide compound for the first time, the reaction steps are simple, the reaction conditions are mild, and expensive reagents are not needed.

The present disclosure provides methods for preparing oligonucleotides. In certain embodiments, the present disclosure provides methods for preparing oligonucleotides using cyclic-phosphate or cyclic-thiophosphate nucleosides. In certain embodiments, the present disclosure provides methods for preparing oligonucleotides using nucleophiles selected from substituted thiol nucleophiles, substituted nitrogen-based nucleophiles, substituted phosphine nucleophiles, halides, pseudohalides, azides, and substituted lithium-based nucleophiles.

The application belongs to the field of organic synthesis, and discloses a method for preparing chiral 2-(1,3-diarylallyl)malonate by using a Pd / phosphine oxygen bidentate phosphine phenol ligand catalysis, which comprises the following steps: under a protective atmosphere, mixing P, O-bidentate phosphine phenol ligand, a palladium catalyst, N, O-bis(trimethylsilyl)acetamide, a malonate nucleophilic reagent and an allyl acetate electrophilic reagent in dichloromethane, and reacting to obtain chiral 2-(1,3-diarylallyl)malonate product. The system has the advantages of high enantioselectivity, high catalytic efficiency, wide substrate application range and mild conditions.

The application discloses a kind of full biological base adhesive based on epoxy soybean oil and preparation method thereof.Specifically, the method uses epoxy soybean oil as reaction base, citric acid as nucleophilic reagent to open the epoxy ring of epoxy soybean oil, tannic acid as catechol compound to provide adhesion after crosslinking polymerization, and constructs a biological base crosslinking network structure with excellent bonding performance. The present application is an environmentally friendly adhesive developed based on full biological base raw materials, with the outstanding features of non-toxic, renewable and environmentally friendly. The adhesive uses a one-pot synthesis process, which is simple and easy to implement industrial production. In terms of performance, it performs outstandingly, not only has excellent tensile strength and long-term stability, but also has outstanding water resistance and mildew resistance, making it stand out among similar products. In addition, the product has a wide range of raw materials, obvious cost advantage, and high performance and economic benefit.

The present invention discloses a preparation method and application of a compound based on a benzimidazole-1-ylmethanol core, wherein the compound comprises reacting (1H-benzimidazole-1-yl)methanol with a nucleophilic reagent R-XH to prepare the compound. The present invention uses cheap raw materials and simple synthesis steps, which not only achieves a significant reduction in cost, but also ensures a higher yield, thereby laying a solid foundation for the large-scale production of benzimidazole-1-ylmethanol core compounds. At the same time, the present invention ensures the quality and stability of the final product by accurately controlling the reaction conditions and optimizing the operating process. The compound of the present invention can prevent metal from being corroded in an alkaline environment and the pH value of the test solution does not decrease significantly. The present invention can select suitable chemical reagents and chemicals to modify and replace the compound based on "benzimidazole-1-ylmethanol" as the core according to different needs to meet different needs.

This invention relates to a waterproof coating for walls and its preparation method, belonging to the field of coating technology. The waterproof coating of this invention is prepared from the following components: 50-53 parts by weight of epoxy resin, 75-81 parts by weight of curing agent, and 8.5-11.5 parts by weight of waterproof filler. The waterproof filler is prepared by the following steps: reaction of epoxidized nano-silica with the nucleophilic reagent p-aminophenyl POSS, ring-opening and polymerization of N-acid anhydride, and modification with ethyl isocyanate. This invention uses epoxy resin as the film-forming substance and constructs a waterproof system by adding waterproof filler to prepare a waterproof coating suitable for application on walls. It can achieve a relatively ideal waterproof effect without the need for additives, effectively blocking the intrusion of water, and the coating has a low water absorption rate.

The invention relates to a multi-metal zinc complex, a preparation method and application in polymer depolymerization. The multi-metal zinc complex forms a stable coordinate bond with an organic ligand molecular skeleton, shows excellent chemical stability and substrate adaptability, and can efficiently catalyze the depolymerization reaction of various polymers in a temperature range of 100-250 DEG C. In addition, the ligand framework has adjustability, polymer substrates with different compositions and structures can be optimized, and high-yield recovery of various types of monomers is realized. The catalytic system has wide applicability, can catalyze the bulk depolymerization of the polymer, and also can catalyze the depolymerization in the presence of a nucleophilic reagent. Through a multi-metal concerted catalysis mechanism, the dosage of the catalyst is remarkably reduced, various polymers with the number-average molecular weight in the range of 3.8-807.5 kg / mol can be depolymerized, the depolymerization reaction time is 0.5-24.0 h, side reactions are remarkably inhibited, and excellent industrial application prospects are shown.

The invention relates to cyclotrithio-tri (2-mercaptoethylthio) mercaptan as shown in a formula I and a preparation method and application thereof. A two-step method of thio reaction and nucleophilic substitution is adopted. In the step I, thiourea is used as a sulfur source, epoxy atoms in trioxymethylene are replaced by sulfur atoms one by one under the condition of strong acid, and 1, 3, 5-trithiacyclohexane is generated. In the nucleophilic reaction of acid catalytic activation in the step II, 1, 3, 5-trithioxane and Lewis acid are subjected to coordination complexation firstly, one sulfydryl in dithiol serves as a nucleophilic reagent to attack an electrophilic carbon center of a ring-opening intermediate, a new C-S bond is formed, and a linear intermediate containing sulfydryl is generated; according to the process, three thiol groups are introduced in sequence step by step, and sulfur alkylation substitution is completed. The obtained product has the characteristics of high purity, high light transmittance and large refractive index, and can be used for preparing optical materials with ultrahigh refractive index and high light transmittance.

The invention discloses DNA (deoxyribonucleic acid) coupled non-natural amino acid as well as a synthesis method and application thereof. The synthesis method of the DNA coupled non-natural amino acid comprises the following steps: adding inorganic alkali and 2, 5-dibromohexane diamide into a boric acid buffer solution containing DNA coupled cysteine as shown in a general formula (I) in the specification, adding an organic phase, and reacting at 25-37 DEG C to enable the DNA coupled cysteine to be subjected to desulfurization elimination, thereby obtaining the DNA coupled non-natural amino acid. DNA coupling dehydroalanine shown as a general formula (II) in the specification is obtained; the method comprises the following steps: carrying out nucleophilic addition reaction on DNA coupled dehydroalanine and a nucleophilic reagent under an alkaline condition or carrying out dipolar cycloaddition reaction on DNA coupled dehydroalanine and 2, 5-substituted tetrazole under an ultraviolet condition to obtain the DNA coupled unnatural amino acid. By adopting the method, the integrity of the DNA chain can be effectively ensured, no by-product is generated in the reaction, and a more powerful chemical tool is provided for construction and subsequent modification of a DNA coding molecular library.

A process for upcycling a polymeric waste material containing a polyarylethersulfone (PAES polymer) having less than 20 mol% reactive end groups, comprising depolymerizing the PAES polymer in the presence of a phenolic nucleophile and an alkali salt-forming carbonate agent in a polar aprotic solvent to obtain a PAES reactive macromer of lower molecular weight which is recovered. A composite comprising a resin matrix, reinforcing fibers and the PAES reactive macromer. An article made from a self-crosslinking PAES reactive macromer. Such a PAES reactive macromer contains more than 60 mol% of reactive end group(s) Ref, at most 20 mol% halide end group(s) X, and at most 20 mol% of unreactive end group(s) Ne, based on the total amount of moles of end groups. Preferably, Ref contains at least one group selected from –OH, -NH2, -COOH, –C≡CH, –C≡C–Ar, and / or an OH group connected to –Ara--W-Ara-, wherein Ar is an aryl group, Ara is an allyl-substituted aryl group, and W is a single bond, –C(CH3)2– and / or –SO2–. Preferably, Ne is an alkoxy group, such as methoxy, and X is Cl.

The invention relates to modified lignin and a preparation method and application thereof, and the preparation method comprises the following steps: mixing a wood fiber raw material, resorcinol and an organic acid solution, and stirring and reacting for 0.2-6 hours at 60-200 DEG C under a closed condition to obtain a reaction mixture; the mass ratio of the wood fiber raw material to the resorcinol to the organic acid solution is 1: (0.5-2): (2-20); organic acid in the organic acid solution is a nucleophilic reagent; and filtering the reaction mixture, collecting filtrate, and adding water into the filtrate to adjust the pH value until precipitate is separated out, so that the precipitate is the modified lignin. The preparation method of the modified lignin provided by the invention is mild in process, simple and convenient in flow, green and environment-friendly, and the prepared modified lignin is high in brightness, complete in structure, high in activity and good in dispersity and has multiple functional characteristics of sun protection, oxidation resistance, tyrosinase inhibition, bacterium resistance and the like.

This invention discloses a method for the deamination functionalization of aliphatic nitrosamines, comprising: reacting an aliphatic nitrosamine as shown in formula (II) with a nucleophile in the presence of an acid and a solvent to generate a deamination functionalized product as shown in formula (III); wherein, R 1 R 2 R 3 Each group is independently selected from hydrogen, hydroxyl, alkyl, alkoxy, alkanoyl, alkoxycarbonyl, alkylsulfinyl, alkylsulfonyl, aryl, heteroaryl, phenylalkyl, or R 1 R 2 R 3 Two or three of the functional groups form a non-aromatic ring, cage-like compound; FG is a functional group in which a nucleophile participates in the reaction. The method of this invention has the advantages of inexpensive and readily available raw materials, simple reaction conditions, and wide substrate applicability.

The application discloses a method for electrochemically synthesizing oxothiazolazine alkane compounds, which utilizes an electrochemical sulfur and oxygen oxidation method for olefins by using olefin radical cations and diprotic nucleophiles, can synthesize N / S heterocyclic compounds in a single reaction container, utilizes easily obtained thiols and styrene azide, does not need external oxidants or redox catalysts, can synthesize N / S heterocyclic compounds in a single reaction container, and can widen the way of obtaining complex molecular structures for pharmaceutical chemistry and material science.

The application discloses an allyl compound containing chiral monofluoromalonate diester and an asymmetric catalytic synthesis method and application thereof, the compound has the structure shown in the following formula, has potential biological activity and pharmacodynamic activity, provides strong technical support for development of new drugs, and has high practical value; the synthesis method is started from 1,3-diene and a nucleophilic reagent fluoromalonate diester as raw materials, and the chiral monofluoromalonate diester substituted allyl compound is efficiently synthesized through a chiral metal catalyst. The method has the following characteristics: the raw material is cheap and easy to obtain; no base needs to be added, the reaction condition is mild, and the operation is simple; the substrate has a wide application range, excellent enantioselectivity can be obtained, and good to excellent yield is achieved. The product prepared by the application is a useful fluorine-containing building block, and a variety of fluorine-containing compounds can be synthesized through simple chemical conversion.

The invention particularly relates to 4 '-thiosugar and a preparation method thereof. The preparation method comprises the following steps: taking D-ribose as a raw material, firstly carrying out methylation protection on C1-site hydroxyl, and then carrying out benzylation protection on other hydroxyl; the preparation method comprises the following steps: firstly, carrying out hydrolysis on a glucosidic bond at a C1 site, carrying out reduction through hydroboron to obtain open-loop ribitol (formula V), carrying out sulfonic acid esterification and bromination substitution on hydroxyl of the ribitol, forming a sulfur bridge bond by taking sodium sulfide as a nucleophilic reagent to obtain benzyl-protected thiosugar, oxidizing a thioether bond into sulfoxide, rearranging to obtain acetoxy thioether, and carrying out debenzylation reaction and hydroxybenzoylation reaction to obtain the high-purity acetoxy thioether. According to the present invention, the multi-step intermediate reaction only needs simple purification, the key intermediate can be obtained through recrystallization, the method is simple, the yield is high, the amplification production is convenient, and the obtained 4 '-thiosugar as the basic sugar can participate in the reaction with a variety of basic groups to form the sulfur-containing nucleoside so as to provide the good foundation for the subsequent drug development or activity screening.

The embodiment of the invention relates to the technical field of synthesis of organic compounds, and particularly discloses a tryptophan derivative and a preparation method thereof, and the tryptophan derivative comprises the following raw materials: 4-methyl phenyl sulfonyl indole, 4-methyl-5-oxazolone and a proper amount of chiral catalyst. According to the embodiment of the invention, sulfuryl indole can be converted into a vinyl imine intermediate with unstable chemical properties after being treated by an alkaline reagent, and then 5-oxazolone is used as a nucleophilic reagent and is added onto the vinyl imine intermediate to synthesize the alpha, beta-substituted tryptophan derivative. According to the synthetic route provided by the embodiment of the invention, the raw materials are cheap and easy to obtain, the price is low, the reaction steps are simple, the conditions are mild, the yield is also greatly improved, the problems of harsh related synthetic reaction conditions and lower yield in the existing scheme for preparing the tryptophan derivative by adopting a chemical synthesis method are solved, and the synthetic route has a wide market prospect.

According to the efficient synthesis method of the amide-containing diheterocyclic compound, aryl iodide is used as a substrate, molybdenum hexacarbonyl is used as a safe carbonyl source, palladium is used as a catalyst, organic phosphine is used as a ligand, potassium carbonate is used as alkali, and indole is used as a nucleophilic reagent, so that the amide-containing diheterocyclic compound is successfully synthesized. The method adopts a one-pot method, and has the characteristics of safety and simplicity in operation, wide substrate range, good functional group compatibility, high bonding efficiency and the like. The amide-containing bis-heterocyclic compound is an important intermediate for synthesizing complex molecules such as drugs and natural products, and the method has important significance in the fields of medicines, pesticides, chemical engineering and the like.

The invention relates to the technical field of organic synthesis chemistry and catalytic chemistry, and discloses a reaction method for obtaining a biaryl compound through Suzuki-Miyaura coupling based on C-S bond activation, aryl sulfide is used as an electrophilic reagent, aryl boric acid ester is used as a nucleophilic reagent, in the presence of a nickel catalyst, a bidentate ligand, alkali and copper salt, a reaction is performed in an organic solvent, and the biaryl compound is obtained. Thus, the corresponding biaryl compound is obtained. According to the method, traditional C-S bonds difficult to break can be efficiently activated under uniform conditions, electron-rich and electron-deficient aryl thioethers and various aryl borates are compatible, and the application range of a substrate is wide; meanwhile, the aryl sulfide does not need to be pre-oxidized or pre-functionalized, the steps are simple, the atom economy is high, and the method is suitable for large-scale production. The obtained biaryl compound can be widely applied to the fields of drug molecule synthesis, organic semiconductor materials and the like.

The invention discloses a preparation method of an N-hydroxyurea compound, which specifically comprises the following steps: step 1, sequentially carrying out Lossen rearrangement and nucleophilic reaction under the action of alkali by taking Boc NHOH as shown in a formula 1 as an initial reactant, SO2F2 gas as an acylating agent and an amine compound RR 'NH as a nucleophilic reagent to obtain a tert-butoxyurea compound as shown in a formula 2; and 2, removing the tert-butoxy group from the tert-butoxyurea compound to obtain the N-hydroxyurea compound as shown in a formula 3. The innovation point of the invention is that commercialized easily available gas sulfonyl fluoride promotes Lossen rearrangement of tert-butylhydroxylamine to generate a key intermediate tert-butoxy isocyanate, the key intermediate tert-butoxy isocyanate and a substrate amine compound are subjected to a one-pot reaction to obtain the N-hydroxyurea compound, the reaction conditions are simple, the operation is convenient, the compatibility of substrate functional groups is strong, and the application prospect is good.

The invention discloses a bidentate / polydentate phosphine ligand and hydrogen electrochemical synthesis method, and belongs to the technical field of electrochemical synthesis. The method comprises the following steps: dispersing a phosphine source, a nucleophilic reagent and a catalyst in a solvent in an inert gas atmosphere, and carrying out an electrolytic reaction to obtain a bidentate / polydentate phosphine ligand and hydrogen; through an alternating current electrolysis mode, the influence of oxidizing substances on the trivalent P-H reagent in the electrochemical synthesis process is reduced, the P-H reagent is adopted as a raw material, the only co-product is hydrogen, and the method has the advantages of being environmentally friendly, simple and convenient in step, capable of achieving multiple purposes and the like.

The application discloses a three-component coupling method of aromatic trifluoroalkyl compounds, conjugated olefins and nucleophilic reagents, under the condition of room temperature and inert atmosphere, the aromatic trifluoroalkyl compounds generate aromatic difluoroalkyl-palladium complexes under the condition of a palladium catalyst, a phosphine ligand, an organic solvent, a base and light; the aromatic difluoroalkyl-palladium complexes are added to the conjugated olefins, and then added to amine or 1,3-dicarbonyl compounds to obtain difluoroalkyl functionalization products. The method has the advantages of easy availability of raw materials, simple operation, mild reaction conditions, wide substrate applicability and the like, meets the development requirements of green chemistry, and is expected to be widely applied in the modification of drug molecules or natural product molecules.

The application discloses a method for synthesizing an alpha-position chiral nitrogen heteroaromatic ring under the synergistic catalysis of a chiral phosphoric acid and a Lewis acid, and the method comprises the following steps: taking a nitrogen heteroaromatic ring olefin I as an electrophilic reagent, taking an aryl alkyl boronic acid II as a carbon nucleophile, and under the synergistic catalysis of a Lewis acid catalyst and a chiral phosphoric acid catalyst, in the presence of an organic solvent, an additive and a proton source, performing a conjugate addition-asymmetric protonation reaction to generate an alpha-position chiral nitrogen heteroaromatic compound shown in formula V, and the reaction is shown as follows: The application provides a conjugate addition-asymmetric protonation strategy for a nitrogen heteroaromatic ring olefin, which is synergistically catalyzed by a chiral phosphoric acid and a Lewis acid (Fe(OTs)3) and involves an organic boron reagent, a series of alpha-position chiral nitrogen heteroaromatic compounds are successfully synthesized by using the catalytic system, the highest enantioselectivity reaches 98% ee, and good universality is shown for aryl, heterocyclic and polysubstituted substrates, and the bottleneck problem of low reactivity of 1,1-disubstituted substrates in a traditional method is effectively overcome.

The invention discloses an in-situ self-film-forming antifouling material based on phosphate groups as well as a preparation method and application of the in-situ self-film-forming antifouling material. According to the preparation method, the compounding of a phosphatide component and an antifouling functional component is realized in a polymerization process, and then in order to achieve effective adsorption, the phosphatide component reacts with halosilane and a strong nucleophilic reagent to hydrolyze to generate a phosphate group with a strong coordination effect, so that the antifouling material has a strong anchoring effect. The antifouling material is prepared into a solution system with required concentration and can form a film to form an antifouling coating when being in contact with a metal surface, and the obtained antifouling coating can resist bacteria and fouling and has an anti-corrosion effect.