87 results about "Nucleophile" patented technology

The invention discloses a dechlorination regeneration method of a chlorine poisoning noble metal catalyst and an application of the regenerated noble metal catalyst in polyolefin hydrogenolysis, and the dechlorination regeneration method comprises the following steps: dispersing the chlorine poisoning noble metal catalyst in water, adding a strong nucleophilic reagent for treatment, and carrying out centrifugal separation, washing and drying treatment to obtain the chlorine poisoning noble metal catalyst. The regenerated noble metal catalyst is obtained. A strong nucleophilic reagent dechlorination regeneration strategy under a room temperature mild condition is provided, chemically inert metal-chlorine bonds are broken through a nucleophilic substitution effect, noble metal particles are prevented from being agglomerated and sintered while deep dechlorination is realized, polyolefin hydrogenolysis activity of the catalyst can be completely recovered, activity improvement can be realized, and the catalyst has a good application prospect. Meanwhile, the regeneration cost is greatly reduced, and the regenerated noble metal catalyst can be used for efficiently hydrogenolyzing, upgrading and recycling waste polyolefin to obtain liquid alkane fuel with high additional value.

This invention belongs to the field of chemical synthesis and relates to a method for achieving deuterated methylation of a nucleophile. The invention provides a deuterated methylating reagent, which is obtained by reacting formic acid with deuterated methanol under acidic conditions, followed by a second reaction with thiaanthracite and trifluoromethanesulfonic acid. The nucleophile is then reacted with the deuterated methylating reagent described in claim 1, a base, and a solvent to obtain the deuterated methylated product. This invention also provides a method for achieving deuterated methylation of a nucleophile, which involves dissolving the nucleophile and 5-deuterated methyl-5H-thiophene-5-onium trifluoromethanesulfonate in a suitable solvent, adding a base, and then performing the deuterated methylation reaction at room temperature. In the method provided by this invention, the yield of the product after nucleophile methylation can reach 52% to 95%.

The present invention provides a microcapsule composition comprising at least one core-shell microcapsule, wherein the at least one core-shell microcapsule comprises a core comprising at least one benefit agent and a shell surrounding the core, wherein the shell comprises a resin formed by the reaction of: 5 - a Michael acceptor which is the reaction product of a biodegradable polyester polyol with an α,β-unsaturated acid chloride; and - a Michael donor comprising at least two nucleophilic moieties selected from the group consisting of a nitrogen nucleophile, a sulfur nucleophile, an oxygen nucleophile, a carbon nucleophile, a phosphorus nucleophile, and mixtures thereof, which are capable to react with the 10 acrylic double bond of the Michael acceptor. The invention also relates to consumer products comprising the microcapsule composition, a method for preparing the microcapsule composition and to the use of the microcapsule composition to enhance the performance of a benefit agent in a consumer product.

The present disclosure provides methods for preparing oligonucleotides. In certain embodiments, the present disclosure provides methods for preparing oligonucleotides using cyclic-phosphate or cyclic-thiophosphate nucleosides. In certain embodiments, the present disclosure provides methods for preparing oligonucleotides using nucleophiles selected from substituted thiol nucleophiles, substituted nitrogen-based nucleophiles, substituted phosphine nucleophiles, halides, pseudohalides, azides, and substituted lithium-based nucleophiles.

The application belongs to the field of organic synthesis, and discloses a method for preparing chiral 2-(1,3-diarylallyl)malonate by using a Pd / phosphine oxygen bidentate phosphine phenol ligand catalysis, which comprises the following steps: under a protective atmosphere, mixing P, O-bidentate phosphine phenol ligand, a palladium catalyst, N, O-bis(trimethylsilyl)acetamide, a malonate nucleophilic reagent and an allyl acetate electrophilic reagent in dichloromethane, and reacting to obtain chiral 2-(1,3-diarylallyl)malonate product. The system has the advantages of high enantioselectivity, high catalytic efficiency, wide substrate application range and mild conditions.

The application discloses a kind of full biological base adhesive based on epoxy soybean oil and preparation method thereof.Specifically, the method uses epoxy soybean oil as reaction base, citric acid as nucleophilic reagent to open the epoxy ring of epoxy soybean oil, tannic acid as catechol compound to provide adhesion after crosslinking polymerization, and constructs a biological base crosslinking network structure with excellent bonding performance. The present application is an environmentally friendly adhesive developed based on full biological base raw materials, with the outstanding features of non-toxic, renewable and environmentally friendly. The adhesive uses a one-pot synthesis process, which is simple and easy to implement industrial production. In terms of performance, it performs outstandingly, not only has excellent tensile strength and long-term stability, but also has outstanding water resistance and mildew resistance, making it stand out among similar products. In addition, the product has a wide range of raw materials, obvious cost advantage, and high performance and economic benefit.

This invention relates to a waterproof coating for walls and its preparation method, belonging to the field of coating technology. The waterproof coating of this invention is prepared from the following components: 50-53 parts by weight of epoxy resin, 75-81 parts by weight of curing agent, and 8.5-11.5 parts by weight of waterproof filler. The waterproof filler is prepared by the following steps: reaction of epoxidized nano-silica with the nucleophilic reagent p-aminophenyl POSS, ring-opening and polymerization of N-acid anhydride, and modification with ethyl isocyanate. This invention uses epoxy resin as the film-forming substance and constructs a waterproof system by adding waterproof filler to prepare a waterproof coating suitable for application on walls. It can achieve a relatively ideal waterproof effect without the need for additives, effectively blocking the intrusion of water, and the coating has a low water absorption rate.

The invention relates to cyclotrithio-tri (2-mercaptoethylthio) mercaptan as shown in a formula I and a preparation method and application thereof. A two-step method of thio reaction and nucleophilic substitution is adopted. In the step I, thiourea is used as a sulfur source, epoxy atoms in trioxymethylene are replaced by sulfur atoms one by one under the condition of strong acid, and 1, 3, 5-trithiacyclohexane is generated. In the nucleophilic reaction of acid catalytic activation in the step II, 1, 3, 5-trithioxane and Lewis acid are subjected to coordination complexation firstly, one sulfydryl in dithiol serves as a nucleophilic reagent to attack an electrophilic carbon center of a ring-opening intermediate, a new C-S bond is formed, and a linear intermediate containing sulfydryl is generated; according to the process, three thiol groups are introduced in sequence step by step, and sulfur alkylation substitution is completed. The obtained product has the characteristics of high purity, high light transmittance and large refractive index, and can be used for preparing optical materials with ultrahigh refractive index and high light transmittance.

A process for upcycling a polymeric waste material containing a polyarylethersulfone (PAES polymer) having less than 20 mol% reactive end groups, comprising depolymerizing the PAES polymer in the presence of a phenolic nucleophile and an alkali salt-forming carbonate agent in a polar aprotic solvent to obtain a PAES reactive macromer of lower molecular weight which is recovered. A composite comprising a resin matrix, reinforcing fibers and the PAES reactive macromer. An article made from a self-crosslinking PAES reactive macromer. Such a PAES reactive macromer contains more than 60 mol% of reactive end group(s) Ref, at most 20 mol% halide end group(s) X, and at most 20 mol% of unreactive end group(s) Ne, based on the total amount of moles of end groups. Preferably, Ref contains at least one group selected from –OH, -NH2, -COOH, –C≡CH, –C≡C–Ar, and / or an OH group connected to –Ara--W-Ara-, wherein Ar is an aryl group, Ara is an allyl-substituted aryl group, and W is a single bond, –C(CH3)2– and / or –SO2–. Preferably, Ne is an alkoxy group, such as methoxy, and X is Cl.

This invention discloses a method for the deamination functionalization of aliphatic nitrosamines, comprising: reacting an aliphatic nitrosamine as shown in formula (II) with a nucleophile in the presence of an acid and a solvent to generate a deamination functionalized product as shown in formula (III); wherein, R 1 R 2 R 3 Each group is independently selected from hydrogen, hydroxyl, alkyl, alkoxy, alkanoyl, alkoxycarbonyl, alkylsulfinyl, alkylsulfonyl, aryl, heteroaryl, phenylalkyl, or R 1 R 2 R 3 Two or three of the functional groups form a non-aromatic ring, cage-like compound; FG is a functional group in which a nucleophile participates in the reaction. The method of this invention has the advantages of inexpensive and readily available raw materials, simple reaction conditions, and wide substrate applicability.

The invention relates to the technical field of organic synthesis chemistry and catalytic chemistry, and discloses a reaction method for obtaining a biaryl compound through Suzuki-Miyaura coupling based on C-S bond activation, aryl sulfide is used as an electrophilic reagent, aryl boric acid ester is used as a nucleophilic reagent, in the presence of a nickel catalyst, a bidentate ligand, alkali and copper salt, a reaction is performed in an organic solvent, and the biaryl compound is obtained. Thus, the corresponding biaryl compound is obtained. According to the method, traditional C-S bonds difficult to break can be efficiently activated under uniform conditions, electron-rich and electron-deficient aryl thioethers and various aryl borates are compatible, and the application range of a substrate is wide; meanwhile, the aryl sulfide does not need to be pre-oxidized or pre-functionalized, the steps are simple, the atom economy is high, and the method is suitable for large-scale production. The obtained biaryl compound can be widely applied to the fields of drug molecule synthesis, organic semiconductor materials and the like.

The invention discloses a bidentate / polydentate phosphine ligand and hydrogen electrochemical synthesis method, and belongs to the technical field of electrochemical synthesis. The method comprises the following steps: dispersing a phosphine source, a nucleophilic reagent and a catalyst in a solvent in an inert gas atmosphere, and carrying out an electrolytic reaction to obtain a bidentate / polydentate phosphine ligand and hydrogen; through an alternating current electrolysis mode, the influence of oxidizing substances on the trivalent P-H reagent in the electrochemical synthesis process is reduced, the P-H reagent is adopted as a raw material, the only co-product is hydrogen, and the method has the advantages of being environmentally friendly, simple and convenient in step, capable of achieving multiple purposes and the like.

The application discloses a three-component coupling method of aromatic trifluoroalkyl compounds, conjugated olefins and nucleophilic reagents, under the condition of room temperature and inert atmosphere, the aromatic trifluoroalkyl compounds generate aromatic difluoroalkyl-palladium complexes under the condition of a palladium catalyst, a phosphine ligand, an organic solvent, a base and light; the aromatic difluoroalkyl-palladium complexes are added to the conjugated olefins, and then added to amine or 1,3-dicarbonyl compounds to obtain difluoroalkyl functionalization products. The method has the advantages of easy availability of raw materials, simple operation, mild reaction conditions, wide substrate applicability and the like, meets the development requirements of green chemistry, and is expected to be widely applied in the modification of drug molecules or natural product molecules.

The application discloses a method for synthesizing an alpha-position chiral nitrogen heteroaromatic ring under the synergistic catalysis of a chiral phosphoric acid and a Lewis acid, and the method comprises the following steps: taking a nitrogen heteroaromatic ring olefin I as an electrophilic reagent, taking an aryl alkyl boronic acid II as a carbon nucleophile, and under the synergistic catalysis of a Lewis acid catalyst and a chiral phosphoric acid catalyst, in the presence of an organic solvent, an additive and a proton source, performing a conjugate addition-asymmetric protonation reaction to generate an alpha-position chiral nitrogen heteroaromatic compound shown in formula V, and the reaction is shown as follows: The application provides a conjugate addition-asymmetric protonation strategy for a nitrogen heteroaromatic ring olefin, which is synergistically catalyzed by a chiral phosphoric acid and a Lewis acid (Fe(OTs)3) and involves an organic boron reagent, a series of alpha-position chiral nitrogen heteroaromatic compounds are successfully synthesized by using the catalytic system, the highest enantioselectivity reaches 98% ee, and good universality is shown for aryl, heterocyclic and polysubstituted substrates, and the bottleneck problem of low reactivity of 1,1-disubstituted substrates in a traditional method is effectively overcome.

The invention discloses an in-situ self-film-forming antifouling material based on phosphate groups as well as a preparation method and application of the in-situ self-film-forming antifouling material. According to the preparation method, the compounding of a phosphatide component and an antifouling functional component is realized in a polymerization process, and then in order to achieve effective adsorption, the phosphatide component reacts with halosilane and a strong nucleophilic reagent to hydrolyze to generate a phosphate group with a strong coordination effect, so that the antifouling material has a strong anchoring effect. The antifouling material is prepared into a solution system with required concentration and can form a film to form an antifouling coating when being in contact with a metal surface, and the obtained antifouling coating can resist bacteria and fouling and has an anti-corrosion effect.

The invention provides a method for efficiently preparing various substituted chiral phosphoramides, which comprises the following steps: in the presence of an organic solvent, alkali, a chiral ligand and a catalyst, reacting a nucleoside compound or alcohol with racemic amino phosphoryl dichloride or alkoxy phosphoryl dichloride to generate chiral phosphoryl chloride; and reacting the chiral phosphoryl chloride with a nucleophilic reagent to obtain the chiral phosphamide. The synthesis method provided by the invention is simple to operate, high in yield and good in diastereoselectivity or enantioselectivity, and the obtained target compound has the characteristics of good functional group compatibility and wide substrate universality. The obtained product is diversified in structure and good in controllability, and has good application potential in the field of medicine synthesis.

The invention relates to a method for synthesizing trans-isopentenyl substituted indolone under the catalysis of transition metal nickel. Specifically, a metal nickel catalyst (Ni (cod) 2) and tricyclohexylphosphine (PCy3) are used as ligands, C3 unsubstituted indolone is used as a nucleophilic reagent to react with isoprene, and a trans-isopentenyl substituted indolone product is obtained. And then taking the product as a reaction raw material, and carrying out nucleophilic substitution reaction on the product and halogenated alkane under an alkaline condition to obtain the 3, 3-disubstituted indolone with divergent functional groups. According to the invention, isoprene is used as a reaction precursor, a trans-isopentenyl substituted indolone product is obtained with high activity and selectivity, a nucleophilic substitution reaction is relayed, and a new strategy is provided for flexibly and conveniently introducing functional groups with different steric hindrances and electrical properties.

The invention provides a single-component epoxy resin lamination adhesive for a silicon steel sheet as well as a preparation method and application of the single-component epoxy resin lamination adhesive. The single-component epoxy resin lamination adhesive for the silicon steel sheet is prepared from the following raw materials: epoxy resin, a tackifying and toughening agent, a nucleophilic reagent, a curing agent and a coupling agent. The single-component epoxy resin lamination adhesive for the silicon steel sheet provided by the invention is a single component, has the normal-temperature viscosity of less than 30mpas, can be stored for one year at normal temperature, adopts a vacuum impregnation process, is then baked and cured, is used for laminating, bonding and fixing silicon steel sheet laminations, eliminates gaps among the silicon steel sheets, bonds the laminated silicon steel sheets into a whole, reduces magnetic loss and noise, and has the advantages of simple preparation process, low cost and high efficiency. And meanwhile, the silicon steel sheets are prevented from rusting.

The plant material may be infiltrated with a solution having a stabilizer and / or a stabilizer precursor. The stabilizers and / or precursors may be absorbed within amorphous and / or hemicellulosic regions of the cell wall of the plant material. After permeation, the amorphous cellulose and / or hemicellulose may be cross-linked with the stabilizer. The stabilizer precursor may include a nucleophilic agent and an electrophilic agent, and the stabilizer may include a reaction product of a nucleophilic agent and an electrophilic agent. Each of the stabilizer and / or the precursor may have a molecular weight of less than or equal to 500 g / mol during permeation. After cross-linking, the stabilizer may impart higher water stability to the plant material, in particular, to limit swelling of the plant material regardless of the duration of exposure to water and / or the amount of water absorbed by the plant material.

The invention discloses a preparation method for electrocatalytic synthesis of polyfluorinated biaryl, and belongs to the field of organic synthesis. The invention solves the problem that the existing method for synthesizing the complex polyfluorinated aryl compound by using polyfluorinated aromatic hydrocarbon mostly depends on the use of a metal nucleophilic reagent or the redox capacity of a photocatalyst. The method comprises the following steps: uniformly mixing polyfluorinated aromatic hydrocarbon, aromatic hydrocarbon, tetrabutylammonium bromide, ferrocene, potassium hydroxide and an organic solvent, and then carrying out electrochemical reaction. The method is used for preparing the polyfluorinated biaryl through electro-catalytic synthesis.

The invention discloses a preparation method of a proteoglycan protein conjugate carrying a specified connection site. The method comprises the following steps: carrying out recombinant expression on a recombinant tetanus toxin heavy chain C fragment rTTHc containing a Sortase A 7M ligase recognition sequence, introducing O, O '-(ethane-1, 2-diyl) bis (hydroxylamine) as a nucleophilic reagent into the C tail end of the rTTHc under the action of ligase Sortase A 7M, and carrying out specific condensation reaction on the C tail end of the rTTHc as a unique chemical reaction site and polysaccharide carrying an aldehyde group functional group to obtain the tetanus toxin heavy chain C fragment rTTHc. Therefore, polysaccharide protein conjugates with definite polysaccharide and protein connection sites are produced. According to the invention, the problem that the key antigen epitope of the carrier protein and the heterogeneity of the product are possibly damaged by the traditional random modification strategy is solved, the antigen epitope of the carrier protein is prevented from being damaged to a great extent, and a reliable technical scheme is provided for preparing the polysaccharide conjugate vaccine with high quality and high immunogenicity.

The invention provides a method for catalyzing free radical-nucleophilic addition halogenation-functionalization of alkene through a visible light induced iron-based material, and belongs to the technical field of organic chemistry. According to the method, olefin is taken as a reaction substrate, inorganic halide MXn is taken as a halogen source, in the presence of a nucleophilic reagent Nu, a halogen functionalization reaction of olefin is efficiently and highly selectively realized through co-catalysis of an iron-based material and visible light, C-X (X = Cl, Br) and C-Y (Y = X, O, S) are constructed at the same time, and a halogen-functionalization product is prepared. According to the method, halide ions are used for replacing traditional halogen simple substances, and olefin which is low in price and easy to obtain is directly converted into the halide which contains a plurality of functional groups and has a high additional value and subsequent derivation potential through free radical-nucleophilic addition under a mild condition. The method has the advantages of environment friendliness, high selectivity, low energy consumption and the like, and has important theoretical significance and practical application value.

The invention belongs to the technical field of epoxy resin coatings, and particularly relates to a bi-component aliphatic polyamine epoxy graphene acid-resistant coating which comprises epoxy resin in a component A and a curing agent in a component B. The curing agent is perfluoroalkyl secondary amine. Alicyclic diamine and perfluoroalkyl ethylene are subjected to a Michael addition reaction under the action of a catalyst cupric trifluoroacetate, the cupric trifluoroacetate catalyst effectively prevents the perfluoroalkyl ethylene and a generated target product secondary amine from being further subjected to an excessive addition reaction, and the reaction efficiency is improved; after the curing agent is subjected to cross-linking reaction with the epoxy resins in the scheme, a large number of ether bonds existing in a traditional phenolic epoxy amine curing system can be eliminated, so that nucleophilic reagent attack sites are reduced, meanwhile, the curing agent perfluoroalkyl secondary amine is converted into a tertiary amine structure, coordination activation of H to nitrogen atoms is reduced, and a coating is more stable.

The invention relates to the technical field of separation and purification of organic compounds, in particular to an adsorbent, a preparation method of the adsorbent and a purification method of methyl phenyl dichlorosilane. The preparation method of the adsorbent comprises the following steps: S1, carrying out first reaction on cyclodextrin and halogenated epoxypropane in the presence of a basic catalyst to obtain an intermediate; and S2, mixing the intermediate with a silane coupling agent, carrying out a second reaction, and separating the product to obtain the adsorbent. Through the synergistic effect of selective adsorption and rectification of the silane coupling agent modified cyclodextrin, the separation efficiency is high, and the product purity can reach 99.5% or above; wherein the adsorbent can be recycled, and the reagent recovery rate is gt; the comprehensive cost is reduced; in addition, mixed liquid obtained in S11 can be treated through distillation, a desorption agent and / or a nucleophilic reagent are / is recycled, closed-loop process design is adopted, the emission amount of three wastes is reduced, the clean production requirement is met, and the environmental protection property is excellent.

The invention discloses a deamination functionalization method of fatty amine or fatty nitro-amine, which comprises the following steps: reacting fatty amine as shown in a formula (I) or fatty nitro-amine as shown in a formula (II) with a nucleophilic reagent in the presence of acid and a solvent to generate a deamination functionalization product as shown in a formula (III), wherein R1, R2 and R3 groups are independently selected from hydrogen, hydroxyl, amino, alkyl, alkoxy, alkanoyl, alkoxycarbonyl, alkyl sulfinyl, alkyl sulfonyl, aryl sulfonyl, aryl, heteroaryl and phenylalkyl, or two or three of the R1, R2 and R3 groups form a non-aromatic ring and a cage compound; fG is a functional group for the nucleophilic reagent to participate in the reaction. The method has the advantages of cheap and easily available raw materials, simple reaction conditions, wide substrate applicability and the like.

A curable composition comprising a hydroxyl or cyanurate-functional, hyperbranched polycyanurate (PCN) prepolymer obtainable by reversible nucleophilic aromatic substitution (SNAr) between a tri-alkoxy and / or tri-aryloxy 1,3,5-triazine and an alcohol component selected from mono-ols, diols, and polyols. The hyperbranched PCN prepolymer provides low viscosity at high functional-group density and programmable end groups to control molecular weight, functionality, and crosslink density. In particular, end-group programmability enables orthogonal build-outs: hydroxyl-terminated oligomers are further polymerized with alkoxy / aryloxy triazines to yield PCN thermoset networks, while alkoxy / aryloxy triazine-terminated oligomers are subsequently polymerized with polyols or other multifunctional nucleophiles to provide the complementary construction of a cyanurate-rich network.

The invention relates to the technical field of organic chemistry, and particularly discloses a preparation method of (6S) 4, 6, 7, 8-tetrahydro-4-oxopyrrolo [1, 2-a] pyrimidine-6-carboxylic acid. The method comprises the following steps: in the presence of an additive, reacting a compound I or a salt thereof with a hydrogen source or a nucleophilic reagent in a solvent under the catalysis of different metal catalysts to obtain (6S) 4, 6, 7, 8-tetrahydro-4-oxopyrrolo [1, 2-a] pyrimidine-6-carboxylic acid or a salt thereof. According to the invention, allyl ester and benzyl ester derivatives are ingeniously used for replacing common alkyl ester, and mild reaction conditions avoid strong acid and strong alkali environments, so that not only can the phenomenon of chiral racemization caused by product hydrolysis be avoided, but also ester functional groups can be adjusted, and isomer byproducts during ring closing are greatly reduced.

The present invention relates to a method for synthesising nitrogen-containing phosphorus(V) precursors of formula (I), wherein a phosphate compound is reacted with an oxygen acceptor based on a sulfonic anhydride in the presence of a Lewis base LN capable of coordination via a nitrogen atom, wherein the Lewis base LN is a nitrogen-containing heteroaromatic compound containing a six-membered heteroaromatic ring. The present invention also relates to a method for synthesising oxyphosphorus compounds, wherein the method for synthesising nitrogen-containing phosphorus(V) precursors of formula (I) is carried out and the nitrogen-containing phosphorus(V) precursor of formula (I) is reacted with a nucleophile.

The present invention relates to a method for coupling aryl halides with N-nucleophilic reagent compounds, characterized in that the coupling is carried out in the presence of a binuclear copper (II) complex with a substituted salbed-type ligand of formula (I). Also described are novel binuclear copper (II) complexes with a substituted salbed-type ligand within the scope of Formula (I).

Methods of modifying properties of a cellulosic material include depositing an additive onto the cellulosic material, the additive being in a vapor phase and configured to modify one or more properties of the cellulosic material and adsorbing the additive into the cellulosic material, wherein the additive reacts with one or more functional groups of the cellulosic material. The depositing can be an atomic layer deposition of the additive onto the cellulosic material. The additive can be configured to react with a nucleophile in the cellulosic material. One or more properties of the cellulosic material can include hydrophobicity, thermal conductivity, thermal diffusivity, fungo-toxicity, toxicity, wettability, tensile strength, corrosiveness, biodegradability, bio-toxicity, or swelling.