1554 results about "Tetra" patented technology

The present invention relates to large scale preparation of LNA phosphoramidites using a 2-cyanoethyl-N,N,N′,N′-tetra-substituted phosphoramidite and a nucleophilic activator, e.g. 2-cyanoethyl-N,N,N′,N′-tetraisopropylphosphoramidite and 4,5-dicyanoimidazole. The method is faster and more cost efficient that previously known methods.

The present invention provides embolic compositions, methods, and devices for embolizing a body lumen. In one embodiment, the embolic composition comprises a mixture of polyethylene glycol diacrylate (PEGDA), pentaerythritol tetra(3-mercaptopropionate), and a physiologically acceptable buffer solution.

CD20 is a transmembrane protein of the tetra-spanin family expressed on the surface of B-cells and has been found on B-cells from peripheral blood as well as lymphoid tissues. CD20 expression persists from the early pre-B cell stage until the plasma cell differentiation stage. Conversely, it is not found on hematopoietic stem cells, pro-B cells, differentiated plasma cells or non-lymphoid tissues. In addition to expression in normal B-cells, CD20 is expressed in B-cell derived malignancies such as non-Hodgkin's lymphoma (NHL) and B-cell chronic lymphocytic leukemia (CLL). CD20 expressing cells are known to play a role in other diseases and disorders, including inflammation. The present invention includes anti-CD20 antibodies, forms and fragments, having superior physical and functional properties; immunoconjugates, compositions, diagnostic reagents, methods for inhibiting growth, therapeutic methods, improved antibodies and cell lines; and polynucleotides, vectors and genetic constructs encoding same.

One aspect of the present invention is a light emitting element having a layer including an aromatic hydrocarbon and a metal oxide between a pair of electrodes. The kind of aromatic hydrocarbon is not particularly limited; however, an aromatic hydrocarbon having hole mobility of 1×10⁻⁶ cm²/Vs or more is preferable. As such aromatic hydrocarbon, for example, 2-tert-butyl-9,10-di(2-naphthyl)anthracene, anthracene, 9,10-diphenylanthracene, tetracene, rubrene, perylene, 2,5,8,11-tetra(tert-butyl)perylene, and the like are given. As the metal oxide, a metal which shows an electron-accepting property to the aromatic hydrocarbon is preferable. As such metal oxide, for example, molybdenum oxide, vanadium oxide, ruthenium oxide, rhenium oxide, and the like are given.

A composition comprising: polyethylene; as a scorch inhibitor, 2,4-diphenyl-4-methyl-1-pentene; as a cure booster, 3,9-divinyl-2,4,8,10-tetra-oxaspiro[5.5]undecane; and an organic peroxide.

The present invention describes the use of porous metal oxides for the preparative purification of antibodies and biomolecules within a range of particle physical characteristics. Typically, particles from 15 to 100 microns in average diameter with pores sizes ranging from 400 to 600 angstroms and surface areas from 10 to 50 square meters per gram, and pore volumes from 0.1 to 0.4 mL/gram can be used for purification processes. The metal oxide particles that fall within this range of physical properties show enhanced utility and greater chromatographic capacity for antibodies than materials oxide particles falling outside of this range. Metal oxides such as zirconia, titania and alumina can all be modified with a multi-Lewis base moiety such as an organophosphate ethylenediamine-N,N-tetra(methylenephosphonic) acid (EDTPA), to produce a bio-compatible purification media for, biomolecules.

The invention features a method for treating a patient diagnosed with, or at risk of developing, an immunoinflammatory disorder by administering to the patient a tetra-substituted pyrimidopyrimidine, either alone or in combination with one or more additional agents. The invention also features a composition containing a tetra-substituted pyrimidopyrimidine in combination with one or more additional agents.

The invention discloses a tetra-rotor aircraft attitude obtaining method by use of a three-order approximation Picard quaternion. The method comprises the following steps: (1), according to the three-order approximation Picard quaternion, performing attitude solution so as to prevent a gyroscope from integration accumulative errors and reduce differential amplification of noise; and (2), performing Kalman filtering on an attitude angle obtained through the solution so as to effectively filter sensor measuring errors caused by vibration of a tetra-rotor aircraft body and obtain a more accurate attitude angle. The attitude solution method provided by the invention can perform accurate attitude estimation on a miniaturized tetra-rotor aircraft.

This invention is an organic silicon modification acrylic acid ester emulsion that used to environment temperature crosslinking water craft coating. The feature is that it is made by the following way, organosilicon prepolymer is synthesized first, then it is reacted with tetra ethyl ortho silicate, silicon dioxide nanometer particle of modifying surface is synthesized by sol-gel technique. Seed emulsion got by seed emulsion concentrical technique is core, compound consisted by nonsaturated organosilicon monomer, hard monomer, soft monomer and function monomer, and the silicon dioxide nanometer particle said above is shell, then anorganic nanometer particle modified silicon abicin emulsion is got through nucleocapsid trough polymer network polyreaction. The preparing method includes following procedures (1) synthesis of organic silicon prepolymer. (2) Preparing of silicon dioxide nanometer particle. (3) Preparing of seed emulsion. (4) Synthesis of silicon abicin emulsion, then this product is got. Abrasion resistant quality, alkali resistance, water resistance, weather resistance, soiling resistance of the product after film forming is greatly improved.

The present invention belongs to the technical field of biological pharmacy, and in particular relates to a preparation and purification method of tetra-hydroxyl xanthone mango aglycone (norathyriol), and an application thereof in hypoglycemic medicine. Based on biological experiments, mango glycoside is used as raw material; under the condition with phenol and hydroiodic acid, carbon-carbon bonds are broken to produce the crude product of mango aglycone; the crude product is separated and purified through silica gel column chromatography so that the mango aglycone is separated; the yield rate reaches 12 percent, the purity is higher than 95 percent, and the reproduction performance is good; the IGTT of C57BL/6 normal mice is effectively improved with the norathyriol; and simultaneously the quantity of insulin secretion induced by glucose in vivo for the C57BL/6 normal mice can be improved with the norathyriol. Therefore, the mango aglycone can be applied for preparation of hypoglycemic medicine.

Compositions and methods of their use to adhere a variety of materials together are disclosed herein. The compositions include at least tetra calcium phosphate, an effective amount of a compound that is structurally similar to phosphoserine, and can be mixed with an aqueous solution. The compositions provide adhesive and cohesive strength in both wet and dry environments and exhibit significant bond strength upon curing.

The invention discloses a polyolefin wood-plastic composite material. The polyolefin wood-plastic composite material is prepared by blending and extruding the following components in parts by weight: 20 to 80 parts of polyolefin resin, 20 to 80 parts of plant fiber powder, 2 to 8 parts of compatilizer, 1 to 8 parts of lubricant, and 0.1 to 1 part of antioxygen, wherein the lubricant includes pentaerythritol tetra-benzoate. The composite material has the balance torque of 3.2 to 8.4N.M, bending strength of 30.1 to 66.3MPa, and bending modulus of (0.80-22.6)*10<4>MPa. The invention also discloses a preparation method of the polyolefin wood-plastic composite material. The ester bond of the pentaerythritol tetra-benzoate contained in the wood-plastic composite material and the hydroxyl of the plant fibers can produce high hydrogen bond effect, so that the plant fibers can be promoted to be uniformly dispersed, the filling amount can be increased, the product cost is reduced, the defect on the appearance of the product is avoided, the melting and extruding efficiency is improved, and the bending performance and water absorbing performance of the material are improved; and the polyolefin wood-plastic composite material can be used as the high-level polyolefin wood-plastic composite material to be widely applied in the fields such as indoor and outdoor decoration and construction industry.

The invention comprises a substrate for detection of micro-organisms, wherein said substrate comprises a set of molecular markers linked, optionally with linker molecules or moeieties, to a di-, or tripeptide consisting of amino acids X1 and X2, or X1, X2 and X3, in which one of them, for example X1, is a D-amino acid and the others, for example X2 and X3, may be any D- or L-amino acid. Said substrate preferably is used for the detection of Bacillus anthracis. Alternatively, the invention is directed to a substrate for detection of micro-organisms, more specifically P. aeruginosa, wherein said substrate comprises a set of molecular markers linked, optionally with linker molecules or moeities to a tri- tetra or pentapeptide consisting of glycine amino acids. The invention further comprises methods for detection of micro-organisms, specifically Bacillus anthracis and Pseudomonas aeruginosa, with the substrates of the invention and use of the substrate(s) in such a method.

The present invention discloses a porphyrin derivative with large substituent and its pharmaceutical acceptable salt and its preparation method. The described porphyrin derivative is M-5,10,15,20-tetra[(N)-substituted-n-phenyl or heterocyclic radical] porphyrin, in which n represents 2,3 and 4 postion substitution, and M is one of Fe, Mn, Co, Ni, Cu Zn, Sn, Cr and V metal ions. Said invented porphyrin derivative has higher steric hindrance, and can effectively resist the combination of porphyrin with DNA, and can reduce the mutual transformation between the different isomers, reduce toxicity of porphyrin and raise its medicinal practicability. The described porphyrin derivative can be used as small molecular antioxidant for regulating concentration of peroxide between cells of human body or in cell.

Nickel silicide is formed on the basis of a gaseous precursor, such as nickel tetra carbonyl, wherein the equilibrium of the decomposition of this gas may be controlled to obtain a highly selective nickel silicide formation rate. Moreover, any etch step for removing excess nickel may be avoided, since only minute amounts of nickel may form on exposed surfaces, which may then be effectively removed by correspondingly shifting the equilibrium. Consequently, reduced process complexity, enhanced controllability and enhanced tool lifetime may be obtained.

A chitosen-quaternary ammonium salt nanoparticle as the carrier of protein-type medicine is prepared through dissolving chitosan-quaternary ammonium salt in distilled water, stirring while adding solution of sodium tripolyphosphate, cross-linking, centrifugal separation, and freeze drying. It has long relesing period (6 days).

The invention relates to polyimide containing a benzimidazole unit and a preparation method thereof. The polyimide has the following structural formula. The preparation method comprises the following steps of: firstly, performing the reaction on 2,6-disubstituted aniline and aldehyde under the acidic condition to generate a diamine compound 3,3',5,5'-tetra-substituted aromatic diamine; and then, after mixing the synthesized aromatic diamine and a heterocyclic diamine monomer 6-aminophenyl-2-aminobenzimidazole according to a certain ratio, performing the reaction on the mixture and a dianhydride monomer in an organic solvent to obtain the polyimide. The polyimide provided by the invention has excellent solubility property, can be dissolved in conventional solvents such as NMP (N-methyl-2-pyrrolidone) and DMAc (dimethyl acetamide), has excellent heat resistance and mechanical property and has excellent thermal properties of glass-transition temperature of over 410 DEG C, decomposition temperature of over 500 DEG C and the like.

The invention relates to a method for making hydrogen-containing silicone oil, in particular to a method for making methyl phenyl hydrogen-containing silicone oil for the encapsulation of LEDs. The method is characterized in that the methyl-phenyl cyclic siloxane (Dn<Me, Ph>), the tetramethyl tetraethyl cyclic tetra-siloxane (D4<Me, Et>) and hydrocyclotetrasiloxane (D4<H>) are taken as monomers; under the protection of N2, right amount of an end capping agent is added into the monomer mixture to be copolymerized under the action of a catalyst, after the polymerization, the catalyst is filtered and recycled, the low molecular compound of the obtained clear solution is removed in decompression and high temperature conditions, the clear solution without low molecular compound is cooled to the room temperature, and the target product is obtained. The method has the advantages of available raw materials, low cost, moderate conditions, simple technique, simple operation, environmental protection and convenient industrialization. The product made by the method can be widely applied to the enterprises which manufacture and use the LEDs, etc.