2513results about How to "Good sustained release effect" patented technology

Disclosed are microspheres having a core / shell structure and a spherical shape, wherein (a) the core comprises solid-state aripiprazole, and (b) the shell coats all or most of the surface of the core, and the shell comprises a biodegradable polymer; a process for producing the microspheres; and an injectable aqueous suspension formulation containing the microspheres; and the like.

The present invention relates to sustained-release pharmaceutical compositions for ionic pharmaceutically active substances (excluding ionic prostanoic acid derivatives) containing ionic compounds having opposite charges to those of the active substances and increasing hydrophobicity of the active substances. More specifically, the invention relates to sustained-release pharmaceutical compositions comprising the ionic pharmaceutically active substances and the ionic compounds having opposite charges to those of the active substances and increasing hydrophobicity of the active substances that contain hydrophobic groups in the molecule thereof. The pharmaceutical composition of the invention can exhibit excellent sustained release effect of the active substance, irrespective of water solubility possessed by the ionic pharmaceutically active substances.

The invention discloses a preparation method of a core-shell structured synthetic polymer-natural polymer composite fiber, and the method comprises the steps of: (1) selecting one or several of synthetic polymers to dissolve in a solvent, and conducting stirring until complete dissolution; (2) selecting a natural polymer to dissolve in a solvent, or adding a spinning assistant, and carrying out stirring until complete dissolution; and (3) taking the solution prepared in step (1) as an outer tube spinning solution, adopting the solution prepared in step (2) as an inner tube spinning solution, injecting them into the inner tube and the outer tube of a coaxial spinneret, and performing coaxial electrospinning at room temperature. The core-shell structured nano-fiber prepared by the invention selects the synthetic polymer as the shell layer, and can inhibit water molecules from penetrating the natural polymer as the core layer. The natural polymer as the core layer can more effectively encapsulate active substances to avoid inactivation of the active substances in the presence of an organic solvent, so that the core-shell structured composite fiber can play a good drug sustained release role in the drug carrier field, and an integral activity can be maintained.

The invention discloses a liquid compound microbial fertilizer containing polyglutamic acid, and a preparation method and an application thereof, and belongs to the field of compound microbial fertilizers. Bacillus megaterium, bacillus thuringiensis and bacillus amyloliquefaciens are prepared into a bacteria liquid by liquid fermentation, and then the bacteria liquid is mixed with compound nutrients and a gamma-polyglutamic acid according to the mass ratio of 1:1:0.05-0.1 to be prepared into the efficient liquid compound microbial fertilizer. On the basis of good phosphorus dissolving capability of the bacillus megaterium, good insect resistance of the bacillus amyloliquefaciens and good organic matter degrading capability of the bacillus amyloliquefaciens, the purposes of more excellent fertilizer efficiency and lower water consumption are achieved under the characteristics of water retention, fertilizer preservation, and no environmental pollution of the gamma-polyglutamic acid, therefore, the scientific and reasonable matching of the compound fertilizers is formed.

The present invention provides a drug delivery system to a posterior segment wherein a pharmaceutical composition comprising a drug and a vehicle is administered subconjunctivally to form a depot out of the vehicle, and thereby the drug is gradually released from the depot to enable an effective concentration of the drug to be maintained, the pharmaceutical composition comprising the vehicle which is in the form of gel subconjunctivally and the drug suspended in the vehicle.

The present invention relates to sustained-release pharmaceutical compositions for ionic pharmaceutically active substances containing ionic compounds having opposite charges to those of ionic prostanoic acid derivatives and increasing hydrophobicity of the active substances. More specifically, the invention relates to sustained-release pharmaceutical compositions comprising the ionic prostanoic acid derivatives and the ionic compounds having opposite charges to those of the prostanoic acid derivatives and increasing hydrophobicity of these derivatives that contain hydrophobic groups in the molecule thereof.The pharmaceutical composition of the invention can exhibit excellent sustained release effect of the ionic prostanoic acid derivatives, irrespective of water solubility possessed by the ionic prostanoic acid derivatives.

The invention discloses a carbon-based compound fertilizer containing probiotic organisms. The carbon-based compound fertilizer comprises biomass carbon black and probiotics, wherein the biomass carbon black is prepared by the following method: carrying out low-temperature carbonization on agricultural wastes as biomass raw materials to form porous biomass carbon black. The probiotics are prepared by the following method: carrying out amplification culture on beneficial microorganisms and fermenting to form probiotic liquid; and mixing and then carrying out solid-liquid separation and expansion drying to form the probiotics, wherein the beneficial microorganisms are selected from one or more of peanibacillus ploymyxa, trichoderma, nitrogen-fixing bacteria, root nodule bacteria, phosphate-solubilizing bacteria, potassium bacteria, cellulose decomposition bacteria, antibiotic-producing strain and photosynthetic bacteria. The carbon-based compound fertilizer disclosed by the invention is made of microporous biomass carbon, and thus the carbon-based compound fertilizer has extremely-strong adsorption capacity and favorable light absorbing and temperature increasing effects; in addition, the probiotics of the carbon-based compound fertilizer are high in cell viability; and the carbon-based compound fertilizer can be preserved at normal temperature for a long time, can be mixed, granulated and dried with other organic and inorganic fertilizers without being influenced and is remarkable in synergistic action.

The invention discloses a biochar base soil modifier and a preparation method thereof. The biochar base soil modifier comprises the following components in percentage by weight: 95.5-98.5% of biomass carbon black and 1.5-4.5% of probiotics agent. Agricultural waste serves as a biomass raw material to carry out low-temperature carbonization to form the porous biomass carbon black; beneficial microorganism is enlarged and cultivated and is fermented into probiotics liquid; after mixing, solid and liquid separation, flash evaporation and drying are carried out to obtain the probiotics agent; the beneficial microorganism is selected from one or more of paenibacillus polymyxa, trichoderma strains, nitrogen-fixing bacteria, rhizobium, phosphate solubilizing bacteria, potassium bacteria, cellulose decomposition bacteria, antibiotic generation bacteria and photosynthetic bacteria. The biochar base soil modifier disclosed by the invention adopts the microporous biomass carbon which has strong adsorption capability and good light absorption and temperature-increasing effect. The probiotics agent has a high survival rate and can be stored for a long time at the normal temperature, the fertilizer synergy action is obvious, and the soil borne disease can be effectively prevented and cured.

The invention discloses a blending electric spun nanometer fiber film biological compress and preparing method in medicinal biological compress technical domain, which is characterized by the following: choosing chitose or polyvinyl alcohol or water-soluble antibacterial drugs as main raw material; adopting electrostatic spinning method; producing nanometer fiber film. This product possesses the advantages of higher strength, good air perviousness and good biological compatibility.

A PLG copolymer material, termed a PLG(p) copolymer material, adapted for use in a controlled release formulation for a bioactive material is provided, wherein the formulation exhibits a reduced “initial burst” effect when introduced into the tissue of a patient in need thereof. A method of preparation of the PLG copolymer material is also provided, as are methods of use.

The invention relates to a fermented alga liquid fertilizer synergist and a production method and an application thereof. The fertilizer synergist is a fermented alga liquid fertilizer synergist obtained by performing microbial fermentation on natural alga serving as a raw material, preparing an alga extracting solution through procedures such as alkali extraction, filter pressing and the like, and adding chelated state trace elements into a liquid. Due to the adoption of the fermented alga liquid fertilizer synergist disclosed by the invention, the soil urease activity can be suppressed remarkably, slow release of a fertilizer is enhanced, and the crop yield can be increased remarkably; trace elements such as boron, zinc, manganese and the like which are generally lacked in soil in China can be replenished; root growth of crops can be facilitated, root activity is increased, and the capabilities of crops of absorbing phosphorus, potassium and medium and trace elements are increased; and the fermented alga liquid fertilizer synergist has the characteristics of reduction in nutrient loss, avoidance of secondary pollution, reduction in the production cost of a synergic fertilizer, wide raw material source, convenience for adding in fertilizer production and the like, and has a wide application prospect in the production of the synergic fertilizer.

The invention relates to a poly-gamma-glutamic acid synergistic fertilizer for strengthening fertilizer effect, which belongs to the fertilizer field. The invention comprises graininess fertilizer which comprises the poly-gamma-glutamic acid. The contents of the poly-gamma-glutamic acid and fertilizer in weight are as follows: 0.01 to 1 percent of the poly-gamma-glutamic acid and the remained content is fertilizer. The contents of poly-gamma-glutamic acid of the invention are strictly controlled and the poly-gamma-glutamic acid can be conveniently fertilized. The poly-gamma-glutamic acid is combined with to make full use of the feature as absorption promoter of fertilizer of the poly-gamma-glutamic acid, therefore, crops output is further raised. The fertilizer is released slowly and prolonged by around 4 times compared with the traditional fertilizer in soil. The invention promotes crop absorption and inhibits fertilizer ingredient decomposition and loss, therefore, fertilizer use is directly decreased by more than 20 percent. The pollution to environment is reduced without excessive or inappropriate fertilization.

The invention relates to a preparation method of a slow-release pesticide. The method comprises the steps of: adsorbing a pesticidal active compound into a porous material; using a pore channel sealing material to seal the pore channels of a porous carrier; conducting further processing so as to obtain a suspending agent, powder, a granule, a tablet and other products of different preparation forms. The pesticidal active compound can be a pesticide, a bactericide, a herbicide or a plant-growth regulator. The preparation method of a slow-release pesticide in the invention can be used to prepare slow-release powder, slow-release granules, slow-release tablets, slow-release suspending agents and other products of different preparation forms so as to meet different demands of agricultural production, and can control the release of pesticidal active components into a surrounding environment at a predetermined speed or a low speed within a predetermined time. One-time application of a slow release pesticide prepared in the invention can control diseases, pests and weeds of a whole growth period (or a certain period). Thus, the slow-release performance of pesticides can be substantially enhanced, the release time can be prolonged, and long-time stable release of slow release pesticides can be maintained.

The invention relates to biodegradable fluorouracil(Fu) polyester drug-bearing manoparticles with a coating material of polylactic acid, polylactic acid-glycolic acid, polylactic acid-polyethylene glycol block copolymer or polylactic acid-glycolic acid-polyethylene glycol block copolymer and the producing method including: firstly, fully dissolving the copolymer in the dichloromethane, under the ultrasonic shock, injecting the fluorouracil NaOH solution in the dichloromethane solution, dispersing uniformly, forming W / O primary latex, and beating up the primary latex and injecting into the fluorouracil saturated water solution containing 5 wt% of polyvinylalcohol (PVA), and storing in the refrigeratory after freeze-dry. The drug-bearing manoparticle has a drug content which is 10-25% of the microparticle mass, and has a smooth surface, an even diameter distribution, a remarkable slow release function and not adhesive. The micropartical size is 100-1000nm.

The invention discloses a hydrogel paste and a preparation method thereof, wherein the hydrogel paste is composed of three layers: a backing layer, a hydrogel layer and a protecting film layer. The hydrogel layer is arranged between the backing layer and the protecting film layer; the hydrogel layer comprises the following components: 5-10% of macromolecule framework material, 0.5-2% of tackifier, 0.5-1% of filler, 0.03-1% of cross-linking agent, 0.03-1% of cross-linking regulator, 0.5-1% of acid-base regulator, 3-10% of humectant, 0.01-2% of preservative and the balance of distilled water; and the hydrogel layer also comprises 0.01-10% of active ingredient, such as whitening agent, antiphlogistic agent, essential oil, and the like. The hydrogel paste has an excellent slow-release property; the action time of the hydrogel paste is prolonged; a cross-linking effect of the cross-linking agent is fully utilized, so that the hydrogel paste is excellent in viscosity and cohesive strength; and the hydrogel paste is high in oxidation resistance, is safe and free from toxic side effect and is suitable for the treatment of dry, fragile and sensitive skins.

The invention provides composite antibacterial powder and a preparation method thereof. The composite antibacterial powder contains nano silver, zinc and nonmetallic minerals such as nano calcium carbonate or nano hydrotalcite, nano titanium oxide and nano bentonite and the like serving as carriers, wherein the content of the silver is 10 to 20 mass percent, and the content of the zinc is 20 to 40 mass percent. The composite antibacterial powder has high bactericidal factor content, is more convenient in compatibility and application, and saves the cost; the particle diameter of the bactericidal factors is nano-scale, so that the bactericidal capability is stronger; the composite antibacterial powder has illumination resistance, does not change color, and has high temperature resistance, good slow-release property and long-acting property; and the preparation method is simple in process, time-saving, labor-saving and high in production efficiency. The composite antibacterial powder serving as an antibacterial agent can be widely applied to various building materials, glass, coating (containing powdery coating), wood, paper and products thereof, plastics, plastic cement, daily ceramic, chemical materials, various home appliances, daily chemical products, textiles and the like.

The invention relates to a water treatment technique with immobilized microorganisms, and discloses a microorganism slow release body with good slow release effect and capable of controlling water pollution of cage culture in running water areas or rivers / lakes and a preparation method thereof. The microorganism slow release body uses porous natural ore granules as a carrier, and is embedded into the spaces in the porous natural ore granules. The microorganism slow release body is placed into water when application, the microorganisms in the pores revive and grow to predominant bacteria around the porous natural ore granules to gradually absorb ammonia nitrogen organics and nitrite in water, so as to clean water. The microorganism slow release body is especially suitable for controlling water pollution. In addition, the porous natural ore granules have better slow release function and can flow with water to slowly release live bacteria in pores, and the released live bacteria are diluted or dispersed in water, so as not to cause adverse influence on the original ecological environment in the water body.

Disclosed are an injectable sustained-release pharmaceutical formulation and a process for preparing the same. In some embodiments, the formulation comprises an active ingredient in a therapeutically effective amount, an amphipathic molecule, an organic acid and / or a salt thereof which is hardly soluble in water, and an oily solvent. The injectable sustained-release pharmaceutical formulation provides a good sustained-release effect for various active ingredients, in particular peptides, proteins, nucleic acids and saccharides.

The invention relates to organic-inorganic biological mineral composition composite synusiologic fertilizer and the preparation method thereof. The invention comprises the raw materials as follow in weight proportion: 20 to 30 parts of organic raw material, 30 to 60 parts of inorganic fertilizer, 10 to 20 parts of mineral composition raw material, and 1 to 5 parts of synusiologic mushroom. The invention has the advantages of promoting the absorption of crops, increasing the fertilizer absorption rate from primary 34 percent to more than 60 percent, decreasing the fertilizer residue, promoting the growth of the crops, improving the quality of the crops, ensuring the early development of the crops, the rich branching roots, the rich branches, the rich leaves, and early mature, and increasing the yield by 50 to 80 percent. Besides, the invention also has the advantages of restraining the development of pathogenic bacteria inside the soil, decreasing the disease and the harm to the crops, improving the structure of the soil, activating the nutrient of the soil and achieving the synusiologic planting.

The present invention discloses slow-release cationic anti-mud polycarboxylic-type high performance water reducer and a preparation method thereof. The slow-release cationic anti-mud polycarboxylic-type high performance water reducer is successfully synthesized from an unsaturated carboxylic acid, a polyether macromonomer, a cationic unsaturated monomer, an unsaturated esters, a crosslinking agent, a chain transfer agent, an oxidizing agent and a reducing agent as raw materials at room temperature without heat source. By introduction of the long-chain-ester crosslinking agent and the cationic unsaturated monomer, the slow-release cationic anti-mud polycarboxylic-type high performance water reducer has good slow-release and anti-mud effects, is low in admixing volume, high in water-reducing rate, excellent in slump retention ability, and not sensitive to mud contained in sand and stones, and the process does not require an additional heat source, an be carried out at room temperature, and is low in investment, low in cost, and suitable for large scale promotion and application.

The invention relates to the field of fertilizers for acidic soil and particularly relates to a special biochar-based organic and inorganic composite fertilizer for acidic soil and a preparation method thereof. The special biochar-based organic and inorganic composite fertilizer for the acidic soil is prepared from the following raw materials: biochar, an acidity regulating substance, a nitrogen-containing substance, a phosphorus-containing substance, a potassium-containing substance, mineral powder and a granulation binder, wherein the granulation binder comprises attapulgite powder and sodium silicate. The composite fertilizer is prepared by mixing the biochar as a controlled-release material and an adsorption material with other components according to a certain proportion, the matching of the components is reasonable, and the nutritional requirements of growth of crops can be well met; the sustained-release effect is good, and the composite fertilizer only needs to be applied once; the composite fertilizer has the effects of improving the pH value of the soil, improving the content of a carbon pool in soil, improving the aggregate structure and the porosity of the soil and reducing toxicity of heavy metals and organic pollutants and can achieve the effects of saving labor, saving the fertilizer and improving the yield and the quality of agricultural products. The invention further provides the preparation method of the composite fertilizer. The preparation method is simple and feasible.

The invention discloses a preparation method of a double-layer wrapped essence micro-capsule, belonging to the technical field of preparation of essence micro-capsules. The preparation method disclosed by the invention comprises the following steps: (1), carrying out micro-capsule embedding on essence for the first time through complex coacervation; (2), solidifying and separating the micro-capsule; and (3), carrying out embedding on the obtained essence micro-capsule for the second time through the spray drying method, and finally, obtaining the double-layer wrapped micro-capsule. According to the invention, first-time complex coacervation embedding on essence is carried out by selecting whey protein and Arabic gum having low cost and good embedding effect as the wall materials; the mixed solution of Arabic gum, maltodextrin, glucose and soy protein is adopted as the spray wall material for the second-time embedding; and finally, the powdery essence micro-capsule is obtained. The preparation method disclosed by the invention has the advantages of realizing industrial production, and being low in cost, steady in physical and chemical property and the like.

The invention discloses a biomass charcoal based probiotic preparation, which is composed of biomass carbon black and concentrated probiotic preparation based on a weight ratio of (8.85-9.15): (0.85-1.15). The preparation is prepared by using agricultural wastes as biomass raw materials, conducting low-temperature carbonization to form porous biomass carbon black; conducting amplification culture to beneficial microorganism, and fermenting to produce probiotic solution; mixing above materials and separating solid from liquid; and drying by flash evaporation to obtain concentrated probiotic preparation, wherein the beneficial microorganism is one or more of paenibacillus polymyxa, trichoderma, nitrogen-fixing bacteria, rhizobium, phosphate dissolving bacteria, potassium dissolving bacteria, cellulose decomposition bacteria, antibiotic producing bacteria, and photosynthetic bacteria. In addition, the invention also discloses a preparation method for the biomass charcoal based probiotic preparation. The biomass charcoal based probiotic preparation provided by the invention uses microporous biomass charcoal, which has very strong absorption capacity and very good light absorption and warming effect. The probiotic preparation is high in survival rate of live bacteria, can be preserved for a long time at normal temperature and has evident synegistic effect for fertilizer.

The invention relates to the field of agricultural chemistry, in particular relates to a carbon-based controlled-release fertilizer special for potato and a preparation method thereof. The environment-friendly efficient carbon-based controlled-release fertilizer special for the potato is a long-acting granular-carbon-based compound fertilizer which is prepared from waste agriculture and forestry biomasses such as corn core, peanut shell, rice shell, edible fungi substrate and the like, wherein the biological granular carbon is black carbon powder granules (carbon black) which is formed by imperfect combustion of biomasses under anaerobic condition and has various features similar to those of soil humus (acid); and the biological granular carbon has strong capabilities of absorbing and retaining nutrition and moisture, can stimulate growth of crops and has good controlled-release effect on NPK, thus the prepared controlled-release fertilizer only needs to be applied once in the full growth and development period of potatoes, has the characteristics of increasing soil fertility, improving soil structure and the like, is efficient and environment-friendly, and has a wide application prospect.

The invention relates to soluble dietary fiber fruit and vegetable meal replacement powder and a preparation method thereof, in particular to dietary fiber fruit and vegetable meal replacement powder capable of adjusting in-vivo nutrient balance and inhibiting in-vivo fat accumulation and a preparation method, and belongs to the technical field of nutrition and health-care food. The dietary fiber fruit and vegetable meal replacement powder is characterized by consisting of the following components in percentage by weight: 10 to 60 percent of refined konjac powder, 15 to 50 percent of soybean dietary fiber powder, 5 to 15 percent of polydextrose, 10 to 20 percent of coix seed powder, 10 to 20 percent of yam powder, 0 to 2 percent of seasoning, and 0 to 5 percent of vitamin B. The soluble dietary fiber fruit and vegetable meal replacement powder prepared by the method is fine and smooth in mouthfeel, good in brew-up performance and rich in nutrition, and has multiple health-care effects of clearing intestines and stomach, reducing three highs, preventing obesity, whitening and moistening skin and the like.

The invention relates to a method of improving the bacterinertness of a silk fibroin solution. Silk fibroin material has favorable prospects when applied in biomedicine aspect, and thus the search of a method of improving the bacterinertness of silk material is meaningful. The invention comprises a silk fibroin solution preparing working procedure which adopts silk fibroin to prepare the silk fibroin solution and is characterized by also comprising a nanometer noble metal feeding working procedure by selecting nanometer noble metal with the grain diameter between 5 nanometers to 100 nanometers. When a temperature is between 0 DEG C to 50 DEG C, the nanometer noble metal is fed to a stand-by silk fibroin solution and is stirred at a rotating speed of 100-400 round / min to obtain the silk fibroin solution comprising the nanometer noble metal; the concentration of the silk fibroin is 0.5-15w / v percent, and the concentration of the nanometer noble metal is 0.005-0.2w / v percent. The invention can favorably improve the antibiotic performance of the silk fibroin solution so that the silk fibroin can be more widely applied to biological material.

The invention discloses a special saline and alkaline land organic / inorganic compounded fertilizer as well as a preparation method and application thereof. The compounded fertilizer comprises raw materials, namely a mixture 1 and a mixture 2, wherein the weight ratio of the mixture 1 to the mixture 2 is (1.5-3.5):1; the mixture 1 comprises composite charcoal, a biological organic fertilizer, humicacid substances, furfural residues, an improvement preparation and inorganic nutrients which are mixed according to a certain ratio; the mixture 2 comprises a biological organic fertilizer, humic acid substances, furfural residues and water retention aids which are mixed according to a certain ratio. By adopting the product disclosed by the invention, soil structures can be improved, soil porosity can be improved, soil bulk density can be reduced, contents of organic matters in soil can be increased, the cation exchange amount of the soil can be increased, and the pH value of the soil and thetotal amount of water soluble salts in the soil can be reduced. In addition, the fertilizer has functions of slowly releasing acid substances and nutrients, is capable of activating soil, reducing immobilization of soil upon nutrients and increasing the utilization rate of the nutrients, is capable of continuously and stably improving soil, is free of adverse influence upon environments and plants, and is ecological and environmentally friendly.

The invention relates to a slow release pellet of high-stability type cysteamine hydrochloride and a preparation method thereof. The slow release pellet comprises the following components in portionsby weight: 30-70 portions of cysteamine hydrochloride, 20-40 portions of silicon dioxide and 5-25 portions of polymer material as coating wall material. The preparation method comprises the followingsteps: firstly, using silicon dioxide pellets to absorb liquid cysteamine hydrochloride in proportion to form cysteamine hydrochloride particles; then, using the coating wall material to encapsulate the cysteamine hydrochloride particles to form a membrane cavity control structure; and drying the structure to obtain slow release pellets of 50% cysteamine hydrochloride. The slow release pellet hasthe characteristics of stable product quality, high content, reasonable preparation method, easy batch production and simple using method and can be added into the premix.

The invention relates to a multi-vesicular liposome, a blank multi-vesicular liposome and a preparation method and application thereof. The multi-vesicular liposome contains the following components in part by weight: 1 part of liposome, 0.01 to 20 parts of auxiliary emulsifier, 1 to 50 parts of osmotic pressure regulator and medicinal active ingredients; the medicament-to-lipid ratio of the multi-vesicular liposome is 1:(0.1-1):200; the lipid contains of a specific amount of neutral phospholipid, cholesterol and triglyceride; and the auxiliary emulsifier is selected from dextran, polyvinyl pyrrolidone, hydroxyethyl starch, gelatin, albumin, arginine and hydroxymethyl starch. The blank multi-vesicular liposome contains the following components in part by weight: 1 part of lipid, 0.01 to 20 parts of auxiliary emulsifier, 1 to 50 parts of osmotic pressure regulator and 0.1 to 50 parts of ion gradient regulator; the osmotic pressure of the in vivo water phase of the multi-vesicular liposome is equal to the osmotic pressure of human plasma; and the auxiliary emulsifier is as previously mentioned. The multi-vesicular liposome has high entrapment rate, and can achieve good sustained-release effect on in vivo and in vitro experiments.

A chitosen-quaternary ammonium salt nanoparticle as the carrier of protein-type medicine is prepared through dissolving chitosan-quaternary ammonium salt in distilled water, stirring while adding solution of sodium tripolyphosphate, cross-linking, centrifugal separation, and freeze drying. It has long relesing period (6 days).