160 results about "Internal phase" patented technology

The invention discloses a method for preparing lubricating oil microspheres based on a microfluidic technology. The method comprises the following steps: preparing an external phase solution, an intermediate phase solution, an internal phase solution and a collection solution; firstly, the internal phase solution is introduced into the micro-fluidic chip, and after the flow of the internal phase solution is stable, the intermediate phase solution is introduced into the micro-fluidic chip to be sheared with the internal phase solution to form nuclear layer liquid drops. After the core layer liquid drops are generated stably, the external phase solution is introduced into the micro-fluidic chip to be sheared with the core layer liquid drops, so that the external phase solution wraps the outer layer of the core layer to form a shell layer with a core-shell structure, and then the double liquid drops are dropped into a collecting solution containing glutaraldehyde to be crosslinked and cured to form the chitosan lubricating oil microspheres. The chitosan lubricating oil microsphere has the following beneficial effects that the lubricating oil is wrapped in the microsphere through a microfluidic technology, so that the chitosan lubricating oil microsphere is of a core-shell structure, and when the lubricating oil is needed, the lubricating oil in the microsphere is released to improve the friction performance of parts.

The invention relates to the technical field of additives for concrete, and particularly discloses a waterproof synergistic interface agent, an interface permeation type water reducing agent mother solution, an interface permeation type water reducing agent and a preparation method of the interface permeation type water reducing agent. The waterproof synergistic interface agent is prepared from the following raw materials: organic acid modified nano inorganic powder and polyhydroxy acrylate. Through the design of the raw materials of the waterproof synergistic interface agent, the surface active groups, the adsorption performance and the dispersity of the nano inorganic powder are increased, the grafting degree of polyhydroxy acrylate with other large monomers, small monomers and functional monomers is improved, the polyhydroxy acrylate is grafted or dispersed in a water reducing agent mother solution through a polymerization reaction, and the waterproof synergistic interface agent is prepared. By combining the synergistic anti-seepage filling effect of the nano inorganic powder, the internal phase interface structure of the concrete is improved, the adhesiveness of different interfaces and the binding force of new and old concrete interfaces are increased, and the hydration hardening product can improve the compactness and toughness of the concrete and improve the ion penetration resistance and mechanical property of the concrete; the problem that an existing water reducing agent is single in function is solved.

The invention discloses a method for preparing a high internal phase emulsion and delivering curcumin by using transglutaminase mediated casein-carboxymethyl chitosan covalent substances, aims to improve the stability and bioaccessibility of curcumin, and belongs to the field of food processing. The method comprises the following steps: firstly, carrying out ultrasonic treatment on sodium caseinate for a certain time, and carrying out transglutaminase cross-linking reaction on sodium caseinate and carboxymethyl chitosan to obtain a casein-carboxymethyl chitosan covalent substance; and then adding the mixture into the curcumin-loaded corn oil according to a certain proportion, and homogenizing to obtain the curcumin-loaded high internal phase emulsion. The emulsion has good interface characteristics and can effectively encapsulate curcumin. The preparation process is simple, efficient, green and environmentally friendly, the prepared high internal phase emulsion has high stability and good biological accessibility, a new technical means is provided for delivery of curcumin, and the high internal phase emulsion has wide application prospects in the field of food.

The invention provides a soybean amyloid protein fiber, a preparation method thereof, a high internal phase emulsion and application, and belongs to the technical field of protein fibers. The preparation method comprises the following steps: dissolving soybean protein isolate in water, adjusting the obtained soybean protein isolate solution to a first pH value, carrying out ultrasonic treatment and / or first stirring treatment, adjusting the obtained feed liquid to a second pH value, sequentially carrying out second stirring treatment, dialysis and freeze drying, and dissolving the obtained pretreated soybean protein isolate in water, adjusting the pH value of the pretreated soybean protein isolate solution to a third pH value, and sequentially performing hydration treatment and fiber growth treatment to obtain the soybean amyloid protein fiber. The invention provides a soybean amyloid protein fiber preparation method based on ultrasonic pretreatment and / or pH migration pretreatment. The yield and the emulsifying property of the obtained soybean amyloid protein fiber can be remarkably improved.

The invention relates to the field of organic silicon thermal management materials, in particular to a flexible insulating organic silicon thermal management composite material based on a phase change material and a preparation method thereof. The problem that the internal temperature of a battery formed by a common technology cannot be effectively controlled and distributed is solved. Comprising 20%-50% of silicone oil, 0.01%-0.1% of an organosilicon catalyst, 0-25% of a heat conduction filler, 25%-80% of a phase change material, 0%-5% of a flame retardant and 0.01%-0.05% of an inhibitor. The material has excellent mechanical property and heat-conducting property, can be suitable for complex working conditions, and has efficient heat management capability. The product is simple in formula and high in designability, and a polymer network constructed by organic silicon rubber can effectively prevent an internal phase change material from leaking under the action of temperature.

The invention provides a preparation method of a monodisperse microsphere with a porous structure on the surface for rapidly promoting collagen regeneration, which comprises the following steps: (1) dissolving or dispersing a pore-foaming agent and a polymer in an organic solvent to obtain an internal phase fluid; the preparation method comprises the following steps: dissolving a water-soluble surfactant in water, adding a proper amount of an organic solvent, and fully mixing to obtain an external phase fluid or a collection liquid; (2) inputting the internal-phase fluid and the external-phase fluid into a microfluid device to prepare a monodisperse oil-in-water emulsion, collecting the oil-in-water emulsion by adopting a collecting solution, fully standing, and stirring to completely volatilize an organic solvent in the oil-in-water emulsion to obtain monodisperse microspheres; and (3) washing to remove the collection liquid and the pore-foaming agent on the monodisperse microspheres. The surfaces of the monodisperse microspheres prepared by the method have uniformly distributed porous structures, and the pore diameters of the porous structures are uniform. The problem that in the prior art, it is difficult to controllably prepare microspheres with uniform porous structures on the surfaces and used in the field of medical cosmetology can be solved.

Microemulsions are disclosed herein that include a discontinuous internal phase comprising an aqueous solution encompassed within an internal emulsifier, a continuous oil phase encompassing the internal phase; and an external emulsifier encompassing the oil phase. Also disclosed are methods for the use of such microemulsions as drug delivery devices, and methods for treating glaucoma and reducing intraocular pressure.

The invention relates to the technical field of compositions of high-molecular compounds, and particularly discloses a preparation method of a sodium caseinate-epigallocatechin gallate-iron ion ternary complex as well as a product and application thereof. The preparation method comprises the following steps: S1, adding EGCG (epigallocatechin gallate) into an SC solution, and stirring in a shading environment to obtain a binary compound; s2, adding a FeCl3. 6H2O solution into the binary compound, and stirring in a shading environment to obtain a ternary compound; wherein in the ternary complex, the mass ratio of SC to EGCG to Fe < 3 + > is (10-14): 1: (2-4). According to the preparation method disclosed by the invention, the stable ternary complex can be prepared, the ternary complex utilizes the metal phenolic network to modify the sodium caseinate, and a high internal phase emulsion formed after the sodium caseinate is loaded with the beta-carotene can show excellent stability and relatively high encapsulation efficiency, so that the bioavailability of the beta-carotene can be remarkably improved.

The invention provides a preparation method and application of a compound protein preparation, and the preparation method comprises the following steps: dissolving a protein matrix in deionized water, adjusting the pH value to 8.0-8.5, firstly adding an antioxidant, and then adding an oxidant and a reducing agent to obtain a protein coupling solution; dissolving the whey protein isolate in deionized water, adding a thickening agent, stirring, and cooling to room temperature to obtain a proteoglycan composite water phase; and mixing the protein coupling solution and the proteoglycan composite water phase according to a preset proportion, adding the oil phase, carrying out homogenization treatment to form a high internal phase emulsion, carrying out freeze drying, and crushing into particles to obtain the powdery protein pre-preparation. The structural stability of protein molecules is remarkably improved, and protein aggregation and sedimentation are reduced, so that the physical and chemical stability of the protein preparation in the storage and use processes is effectively improved, and the problem of insufficient structural stability in the prior art is solved.

The invention discloses cellulose nanocrystal Pickering emulsion gel with stable protein hydrophobic modification and a preparation method of the cellulose nanocrystal Pickering emulsion gel, oil-in-water type emulsion gel is prepared and formed under the shearing action based on cellulose nanocrystals (CNCs) coated with protein or protein sodium salt with an isoelectric point in a range of 4-6, so that a stable gel network structure is formed; by adjusting conditions of different protein coating proportions, particle concentrations and internal phase proportions, the emulsion gel can obtain different processability, and the emulsion gel based on different performance differences has good application flexibility in 3D printing. The main materials are safe in source and have good biocompatibility and biodegradability, the modification method is green and safe, and the prepared emulsion gel can be used as a food 3D printing base material or a nutrient substance loading material.

The application discloses a preparation method of a high internal phase emulsion stabilized only by proteins, which mixes a completely hydrated protein solution as a water phase with an oil phase, and controls the hydrodynamic characteristics of a shearing emulsification process to obtain the high internal phase emulsion stabilized only by proteins. The preparation method of the application can obtain the high internal phase emulsion stabilized only by food-grade proteins through one-step shearing emulsification without other measures. The prepared high internal phase emulsion has good gel characteristics, stability and high safety, and can be used as a substitute for partially hydrogenated vegetable oil and saturated fatty acids. Meanwhile, the method is simple in operation, low in preparation cost and suitable for large-scale industrial promotion.

The invention discloses a high-internal-phase emulsion and a graded porous material prepared from the high-internal-phase emulsion, the high-internal-phase emulsion comprises an oil phase and a water phase, the oil phase comprises a polymeric monomer, a crosslinking monomer, a foaming pore-forming auxiliary agent, an emulsifier and an initiator; according to the invention, the foaming pore-forming auxiliary agent is introduced into the high internal phase emulsion with a water-in-oil (W / O) structure, and the foaming pore-forming auxiliary agent is uniformly dispersed in an oil phase, so that the emulsification of the high internal phase emulsion is not influenced, and the integrity of a first-level foam skeleton structure formed after curing is not influenced; meanwhile, the foaming pore-forming auxiliary agent can be decomposed or volatilized at the polymerization temperature, gas is formed, pores are formed, and a large number of communicated micropores are formed in the continuous support, so that the obtained porous material has a first-stage macroporous structure and a second-stage microporous structure at the same time.

The application discloses an emulsification system and a preparation method of high internal phase emulsion in a continuous cutting environment, wherein the emulsification system comprises a premixing device for premixing raw materials to obtain a mixed liquid, a rotary emulsification device capable of rotating around an axis, the rotary emulsification device comprising a plurality of concentric rotary packing layers, each rotary packing layer being provided with an independent flow channel, the flow channel comprising opposite feeding ports and discharging ports, and a feeding mechanism, a plurality of feeding mechanisms being respectively arranged at the inner periphery or the outer periphery of each rotary packing layer to supply the mixed liquid to the feeding ports. The high internal phase emulsion product with uniform particle size and good stability can be produced by adopting a continuous operation mode and by accurately controlling process parameters such as continuous rotary cutting speed and temperature. Compared with traditional emulsification equipment, the system has high efficiency and wide application range, and is especially suitable for scale preparation of high-viscosity emulsion.

The invention belongs to the technical field of functional emulsion and food processing, and particularly relates to temperature response type high internal phase emulsion and a preparation method and application thereof. The preparation method comprises the following steps: stirring and mixing a starch aqueous solution and an OSA alcoholic solution for reaction to obtain OSA-starch; the preparation method comprises the following steps: dissolving OSA-starch in distilled water to obtain an OSA-starch solution, and then heating and uniformly mixing the OSA-starch solution with a glycyrrhizic acid solution to obtain a water-phase solution; and carrying out high-speed homogenization treatment on the obtained water-phase solution and vegetable oil to obtain the temperature-responsive high-internal-phase emulsion. According to the invention, an aqueous phase solution prepared from OSA-starch and glycyrrhizic acid is introduced into vegetable oil to form the temperature-responsive high-internal-phase emulsion, the prepared temperature-responsive high-internal-phase emulsion has high safety and good stability, rheological properties can be regulated and controlled through temperature, a solution is provided for food system individuation, and the temperature-responsive high-internal-phase emulsion has good application prospects. The method has a good application prospect in the food industry and related fields.

The present invention relates to aransdermal therapeutic system for the transdermal administration of a systemically active agent having a self-adhesive layer structure. The transdermal therapeutic system includes (A) a backing layer, and (B) a dried biphasic layer. The dried biphasic layer has (a) an outer phase having a composition comprising 75% to 100% of a polymer or polymer mixture, and (b) an inner phase having a composition that includes at least one active agent. The inner phase forms dispersed deposits in the outer phase, with the dried biphasic layer including (c) from 0.1% to 3.5% of an interface mediator other than silicone oil, with the interface mediator having with a kinematic viscosity of from 10 cSt to 100 000 cSt at 25° C.

A method of forming a high internal phase emulsion (HIPE) foam is provided. A nitroxide-containing monomer can be used in combination with other monomers that can then be used to make a high internal phase emulsion foam upon curing. The nitroxide group can subsequently be used to control the radical polymerization of many monomers, which can be grafted from the surface of the high internal phase emulsion foam. The resulting foam can be useful in performing separations of radioactive species, metals, metal ions, multi-element ions, metal complexes, halides, and organic chemical species in chemical process streams, clean-up operations, etc.

The invention discloses a high internal phase gel emulsion using rosin modified hydroxyethyl cellulose and a surfactant to synergistically stabilize and a preparation method of the high internal phase gel emulsion. Rosin modified hydroxyethyl cellulose (DA) (EO) 5GE-g-HEC with a specific rosin grafting rate is selected as a main emulsifier, and the surfactant with a specific structure is selected as an auxiliary emulsifier; through the synergistic effect of rosin modified hydroxyethyl cellulose and a surfactant, the water-in-oil type high-internal-phase gel-state emulsion with elastic dominant rheological properties is prepared, the rheological properties of the emulsion are shown as follows: the energy storage modulus is always higher than the loss modulus, the loss factor is smaller than 0.4, the emulsion is free of oil-water layering after standing for 6 months, and the emulsion is inverted and does not flow when the concentration reaches the standard; meanwhile, the particle size of the liquid drops is accurately regulated and controlled within the range of 10-40 microns, the half-peak width of particle size distribution is reduced by more than 40%, the distribution concentration ratio is remarkably improved, and an ideal basic system is provided for material template application due to the unique rheological property and stability of the liquid drops.

The invention discloses a high internal phase emulsion with a nested structure, a preparation method thereof and a porous material, the high internal phase emulsion has at least one layer of nested structure, the nested structure is an HIPE-1 / HIPE-2 structure, the HLB value of an emulsifier A used by the HIPE-1 is recorded as H1, the HLB value of an emulsifier B used by the HIPE-2 is recorded as H2, H1 and H2 meet the condition that H1 is greater than H2, and the difference between H1 and H2 is 8-12; according to the preparation method disclosed by the invention, the emulsifying agents in the HIPE-2 emulsion and the HIPE-1 emulsion are controlled to have a certain difference value, so that the interface structures of at least two different HIPE emulsions in the obtained high-internal-phase emulsion are stable and are immiscible with each other, and the finally obtained porous material has multistage pore diameters and provides a bionic carrier for tissue engineering, drug screening and the like.

An oil-based treatment fluid for use in subterranean operations may comprise an invert emulsion including an aqueous internal phase and an oil external phase. The aqueous internal phase is solids free and comprises a two-salt brine and a true crystallization temperature reduction additive. The two-salt brine comprises a bromide and a nitrate, wherein the bromide brine has a density of about 14.2 lbs / gal to about 17 lbs / gal. There are no additional salts in the aqueous internal phase; The bromide brine has a first true crystallization temperature without inclusion of a true crystallization temperature reduction additive and a second true crystallization temperature with a true crystallization temperature reduction additive that is lower than the first true crystallization temperature reduction additive.

The invention discloses a high-internal-phase emulsion, a porous material with a graded communicated pore structure and application, the high-internal-phase emulsion comprises an oil phase and a water phase, and the oil phase comprises a polymeric monomer, a crosslinking monomer, an emulsifier, an initiator and a polymer pore-foaming agent. According to the preparation method, the polymer pore-foaming agent is introduced into the high internal phase emulsion, and the polymer pore-foaming agent can form secondary pores in the porous material formed by curing the high internal phase emulsion in a dissolving manner, so that the finally obtained porous material has hierarchical structures with large-size pore diameters and small-size pore diameters at the same time; the porous material with the hierarchical structure is obtained.

The invention belongs to the field of food engineering, and particularly relates to sphere-like starch-based nanoparticles as well as a preparation method and application thereof. The method comprises the following steps: performing enzymolysis and aging treatment on sweet potato starch gelatinization liquid to obtain rod-like starch nanoparticles, and further performing cooling and aging treatment on the rod-like starch nanoparticles and a small amount of whey protein solution under a hydrothermal condition to obtain the sphere-like starch-based nanoparticles. According to the method provided by the invention, the rod-like nanoparticles which are less than 10 nm and do not have the emulsifying property are further modified and processed to prepare the sphere-like nanoparticles with the scale of 10-30 nm and the high internal phase emulsifying property, the emulsifying effect of the sphere-like nanoparticles can be compared with that of whey protein with the same concentration, and the high internal phase emulsion is small in droplet particle size, good in storage stability, low in cost and wide in application prospect.

The invention discloses a method for improving 3D printing characteristics of starch gel through rapeseed protein high internal phase emulsion, and belongs to the technical field of food 3D printing. According to the method, modified rapeseed protein-quercetin compound stable high-internal-phase emulsion and starch gel are used as raw materials, the high-internal-phase emulsion is mixed with starch paste according to different proportions, and 3D printing is carried out. By adding the modified rapeseed protein-quercetin compound high internal phase emulsion, the viscosity of starch paste can be effectively reduced, the printing precision is improved, the phenomena such as chapping caused by moisture evaporation of gel are relieved, and the 3D printing characteristics of the starch gel are improved. According to the novel technology disclosed by the invention, room-temperature extrusion of the starch gel can be realized, the surface of a product is prevented from being cracked and hard, slow release of active ingredients can be realized, and the swallowing difficulty of the product is reduced. The method is easy to operate, the quality of printed products is good, and meanwhile application of the rapeseed protein and the starch gel thereof in the field of food 3D printing can be expanded.

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a pharmaceutical composition containing briracetam and a preparation method of the pharmaceutical composition. A pharmaceutical composition of the present application comprises a particle having an intra-particle phase and an extra-particle phase, the particle comprising, based on the total weight of the particle: Briracetam present in the intra-particle phase; the diluent in the particle inner phase is lactose monohydrate and lactose anhydrous in a weight ratio of 1: (0.5-2); a disintegrant present in the particulate inner phase and the particulate outer phase; and a lubricant present in the particulate outer phase. By controlling the weight ratio of the diluent types, the defect of easy sticking is improved under the condition that an adhesive beta-cyclodextrin is not added, and it is guaranteed that intermediate particles are tableted smoothly and are convenient to form; besides, by controlling the particle size of the active components and the dosage of the external phase disintegrating agent in the particles, the prepared briracetam preparation has the dissolution rate and bioequivalence equivalent to those of the original tablet, and the stability is superior to that of the original tablet.

The invention belongs to the field of emulsion preparation, and particularly discloses a preparation method of a high-internal-phase Pickering emulsion with stable Maillard conjugates, which comprises the following steps: respectively preparing a Zein aqueous solution and a kappa-carrageenan aqueous solution, and then mixing the Zein aqueous solution and the kappa-carrageenan aqueous solution to obtain a mixed solution; carrying out ultrasonic-assisted water bath reaction on the mixed solution at 70 + / -10 DEG C, then centrifuging, dialyzing the obtained supernatant, and drying; dissolving the obtained Maillard conjugate solid particles in distilled water to obtain a water phase; slowly dropwise adding medium-chain triglyceride serving as an oil phase into the water phase at a constant speed, mixing a system formed by the water phase and the oil phase, and homogenizing by using a high-speed shearing machine to obtain HIPPEs; the HIPPEs are high internal phase Pickering emulsion with stable Maillard conjugates. The emulsion disclosed by the invention shows excellent encapsulation efficiency in the aspect of delivering bioactive ingredients (such as dihydromyricetin).

The present invention relates to a chickpea protein high internal phase emulsion with high freeze-thaw stability based on interface regulation and its preparation method and application, which belongs to the technical field of emulsion preparation. The preparation of the high internal phase emulsion of the present invention includes: adjusting the pH of the chickpea protein solution to 8-9, ultrasonic treatment, then adding a polysaccharide solution and uniformly mixing, heating the reaction in a water bath, centrifuging the reaction product after the reaction is completed, taking the supernatant and freeze-drying to obtain a protein-polysaccharide conjugate; dissolving the obtained protein-polysaccharide conjugate in water as an aqueous phase; mixing flavor oil and vegetable oil, stirring evenly, as an oil phase; mixing the aqueous phase and the oil phase, and shearing at high speed to obtain a high internal phase emulsion with high freeze-thaw stability. The chickpea protein high internal phase emulsion not only has good freeze-thaw stability, but also has the characteristics of significant gelation, can give fish paste products good freeze-thaw stability, and has broad application prospects.

The present application relates to a kind of lignin-based high internal phase Pickering emulsion and its preparation method, belong to Pickering emulsion technical field.To solve the problem that stable O / W high internal phase Pickering emulsion cannot be obtained with unmodified lignin nanoparticles as stabilizer, the present application provides a kind of O / W oil-in-water lignin-based high internal phase Pickering emulsion, and the water phase is the suspension of ultrapure water containing spherical lignin nanoparticles and PVP, and the volume ratio of water phase and oil phase is 25:75.The lignin-based high internal phase Pickering emulsion prepared in the present application is not disturbed at room temperature after 7 days of storage, and no change such as emulsion system appears deoiling, which indicates that under the condition of high oil load and low stabilizer addition, the lignin-based high internal phase Pickering emulsion realizes excellent storage stability.

The invention provides a controllable photo-thermal-enzymatic degradation porous material as well as a preparation method and application thereof. The controllable photo-thermal-enzymatic degradation porous material is prepared from the following raw materials: an oil phase mixture and a water phase mixture, the oil phase mixture comprises an enzyme sensitive polymer base material, a random heteropolymer (RHP)-enzyme compound, Janus photo-thermal nanoparticles, an internal phase dispersing agent and a solvent; the aqueous phase mixture comprises water, electrolyte and alginate. According to the porous material provided by the invention, the Janus photo-thermal nanoparticles and the RHP-enzyme compound are coupled, under near-infrared light, RHP conformational change can be triggered to release BC lipase, degradation of the porous material can be triggered under the mild condition of 37 DEG C, and the degradation rate within 48 hours can reach 98%.

The invention provides a preparation method of a high-stability high-internal-phase emulsion emulsified by disodium monotetradecyl phosphate (TP2Na), the type of the obtained high-internal-phase emulsion is an oil-in-water (O / W) type, and the volume percentage of an oil phase is not lower than 75% and can reach 92.3% to the maximum. The high-internal-phase emulsion obtained by the invention is extremely good in stability, and the stability time at 25 DEG C can reach 151 days at most. The use amount of the surfactant TP2Na required by the obtained high internal phase emulsion is low, and the mass percentage of the surfactant TP2Na in the emulsion is not more than 3.33%. The surfactant TP2Na provided by the invention is biodegradable and extremely good in emulsifying capacity, and can be suitable for preparing high internal phase emulsion from various liquid alkane mineral oil, dimethyl silicone oil and grease. The preparation method of the high internal phase emulsion provided by the invention is simple, low in equipment requirement, low in production cost and free of emission of three wastes.

The invention specifically discloses a high internal phase emulsion. The high internal phase emulsion comprises an oil phase raw material and a water phase raw material, the oil-phase raw materials comprise an acrylate monomer, a cross-linking agent, an emulsifier and a photoinitiator; the acrylate monomer is selected from one or a composition of more than one of ethyl heptyl acrylate, 2-ethylhexyl acrylate, 2-ethylhexyl methacrylate, benzyl methacrylate and dodecyl methacrylate. The high internal phase emulsion with the composition disclosed by the invention has relatively short light curing time; therefore, when the high internal phase emulsion is used for preparing the water absorbing material, the production efficiency can be improved.

The preparation method comprises the following steps: respectively preparing a plant active extract and a zinc carnosine homogeneous solution; adding a plant active extract into the zinc carnosine homogeneous solution, adding a buffering agent and a coupling agent to obtain an external phase solution, dropwise adding the external phase solution into the internal phase solution, and cross-linking to form gas-producing coagulation beads; the preparation method comprises the following steps: placing aerogenic beads at an ambient temperature of-40 DEG C, carrying out pre-freezing for 3-4 h, carrying out vacuum heating to-10 DEG C, drying for 24 h to obtain aerogel particles, spraying freeze-dried Ackermania muciniphila on an enteric-coated film to obtain enteric-coated pellets, and mixing the enteric-coated pellets and the aerogel particles to obtain the composition with the functions of nourishing the stomach and resisting the helicobacter pylori. The problems that the composition cannot be delivered at a fixed point and the activity is attenuated are solved.