62 results about "Internal phase" patented technology

The invention discloses a high-internal-phase emulsion and a graded porous material prepared from the high-internal-phase emulsion, the high-internal-phase emulsion comprises an oil phase and a water phase, the oil phase comprises a polymeric monomer, a crosslinking monomer, a foaming pore-forming auxiliary agent, an emulsifier and an initiator; according to the invention, the foaming pore-forming auxiliary agent is introduced into the high internal phase emulsion with a water-in-oil (W / O) structure, and the foaming pore-forming auxiliary agent is uniformly dispersed in an oil phase, so that the emulsification of the high internal phase emulsion is not influenced, and the integrity of a first-level foam skeleton structure formed after curing is not influenced; meanwhile, the foaming pore-forming auxiliary agent can be decomposed or volatilized at the polymerization temperature, gas is formed, pores are formed, and a large number of communicated micropores are formed in the continuous support, so that the obtained porous material has a first-stage macroporous structure and a second-stage microporous structure at the same time.

The invention discloses a high internal phase gel emulsion using rosin modified hydroxyethyl cellulose and a surfactant to synergistically stabilize and a preparation method of the high internal phase gel emulsion. Rosin modified hydroxyethyl cellulose (DA) (EO) 5GE-g-HEC with a specific rosin grafting rate is selected as a main emulsifier, and the surfactant with a specific structure is selected as an auxiliary emulsifier; through the synergistic effect of rosin modified hydroxyethyl cellulose and a surfactant, the water-in-oil type high-internal-phase gel-state emulsion with elastic dominant rheological properties is prepared, the rheological properties of the emulsion are shown as follows: the energy storage modulus is always higher than the loss modulus, the loss factor is smaller than 0.4, the emulsion is free of oil-water layering after standing for 6 months, and the emulsion is inverted and does not flow when the concentration reaches the standard; meanwhile, the particle size of the liquid drops is accurately regulated and controlled within the range of 10-40 microns, the half-peak width of particle size distribution is reduced by more than 40%, the distribution concentration ratio is remarkably improved, and an ideal basic system is provided for material template application due to the unique rheological property and stability of the liquid drops.

The invention discloses a high internal phase emulsion with a nested structure, a preparation method thereof and a porous material, the high internal phase emulsion has at least one layer of nested structure, the nested structure is an HIPE-1 / HIPE-2 structure, the HLB value of an emulsifier A used by the HIPE-1 is recorded as H1, the HLB value of an emulsifier B used by the HIPE-2 is recorded as H2, H1 and H2 meet the condition that H1 is greater than H2, and the difference between H1 and H2 is 8-12; according to the preparation method disclosed by the invention, the emulsifying agents in the HIPE-2 emulsion and the HIPE-1 emulsion are controlled to have a certain difference value, so that the interface structures of at least two different HIPE emulsions in the obtained high-internal-phase emulsion are stable and are immiscible with each other, and the finally obtained porous material has multistage pore diameters and provides a bionic carrier for tissue engineering, drug screening and the like.

The invention discloses a high-internal-phase emulsion, a porous material with a graded communicated pore structure and application, the high-internal-phase emulsion comprises an oil phase and a water phase, and the oil phase comprises a polymeric monomer, a crosslinking monomer, an emulsifier, an initiator and a polymer pore-foaming agent. According to the preparation method, the polymer pore-foaming agent is introduced into the high internal phase emulsion, and the polymer pore-foaming agent can form secondary pores in the porous material formed by curing the high internal phase emulsion in a dissolving manner, so that the finally obtained porous material has hierarchical structures with large-size pore diameters and small-size pore diameters at the same time; the porous material with the hierarchical structure is obtained.

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a pharmaceutical composition containing briracetam and a preparation method of the pharmaceutical composition. A pharmaceutical composition of the present application comprises a particle having an intra-particle phase and an extra-particle phase, the particle comprising, based on the total weight of the particle: Briracetam present in the intra-particle phase; the diluent in the particle inner phase is lactose monohydrate and lactose anhydrous in a weight ratio of 1: (0.5-2); a disintegrant present in the particulate inner phase and the particulate outer phase; and a lubricant present in the particulate outer phase. By controlling the weight ratio of the diluent types, the defect of easy sticking is improved under the condition that an adhesive beta-cyclodextrin is not added, and it is guaranteed that intermediate particles are tableted smoothly and are convenient to form; besides, by controlling the particle size of the active components and the dosage of the external phase disintegrating agent in the particles, the prepared briracetam preparation has the dissolution rate and bioequivalence equivalent to those of the original tablet, and the stability is superior to that of the original tablet.

The invention provides a controllable photo-thermal-enzymatic degradation porous material as well as a preparation method and application thereof. The controllable photo-thermal-enzymatic degradation porous material is prepared from the following raw materials: an oil phase mixture and a water phase mixture, the oil phase mixture comprises an enzyme sensitive polymer base material, a random heteropolymer (RHP)-enzyme compound, Janus photo-thermal nanoparticles, an internal phase dispersing agent and a solvent; the aqueous phase mixture comprises water, electrolyte and alginate. According to the porous material provided by the invention, the Janus photo-thermal nanoparticles and the RHP-enzyme compound are coupled, under near-infrared light, RHP conformational change can be triggered to release BC lipase, degradation of the porous material can be triggered under the mild condition of 37 DEG C, and the degradation rate within 48 hours can reach 98%.

The invention provides a porous ceramic material prepared based on a high internal phase emulsion template method and a preparation method and application thereof. The porous ceramic material is prepared from the following raw materials: a high internal phase emulsion and an adhesive, the high internal phase emulsion comprises a continuous phase and a dispersed phase; the continuous phase is a ceramic precursor aqueous solution; the dispersion phase is an emulsifier oil phase solution; the volume fraction of the dispersion phase in the high internal phase emulsion is 74-95%. According to the preparation method, the size of emulsion droplets is accurately regulated and controlled through a high internal phase emulsion template method, and accurate control over the pore diameter of the ceramic material is achieved, so that the porous ceramic material has high porosity and high strength, and is stable in structure, controllable in average pore diameter and wide in application range.

The invention provides a high internal phase emulsion, a preparation method thereof and a porous foam material. The high internal phase emulsion comprises an oil phase mixture and a water phase mixture, the oil-phase mixture comprises a surfactant, a vinyl monomer, an acrylate monomer, a cross-linking agent, an oil-soluble initiator and an auxiliary surfactant; the water-phase mixture comprises water, electrolyte, a pH regulator and a water-soluble initiator; the surfactant is prepared from a pH (Potential of Hydrogen) responsive PS (Polystyrene)-PAA (Polyacrylamide)-PS (Polystyrene) triblock copolymer. According to the invention, the pH responsive PS-PAA-PS triblock copolymer is introduced into the high internal phase emulsion as a surfactant, the pH responsiveness of the triblock copolymer is utilized, more small holes can appear in the HIPE emulsion obtained by emulsification, and the small holes can further improve the specific surface area and the water absorption and water retention capacity of the material after forming the porous foam material.

The invention relates to a static mixing tube and a preparation method and application thereof. The static mixing pipe comprises a static mixing outer pipe and a high internal phase emulsion foam core body. According to the static mixing pipe, the high-internal-phase emulsion foam core body serves as an inner core of the static mixing outer pipe, and the unique porous structure and mechanical property of the high-internal-phase emulsion foam core body are utilized, so that the obtained static mixing pipe has the excellent performance of high connectivity, high porosity and good shearing effect; further, the purpose of efficiently, uniformly and continuously preparing the high-internal-phase emulsion can be achieved.

The invention relates to an anti-radiation high-internal-phase emulsion as well as a preparation method and application thereof. The anti-radiation high internal phase emulsion comprises an oil phase, a water phase and an anti-radiation dispersion liquid, wherein the oil phase comprises a polymerizable monomer, a crosslinking monomer and a functional monomer; the anti-radiation dispersion liquid comprises an anti-radiation filler. The preparation method provided by the invention can effectively avoid agglomeration of the anti-radiation filler, and anti-radiation high-internal-phase emulsion foam prepared from the anti-radiation high-internal-phase emulsion provided by the invention has the characteristics of low density, good mechanical property and excellent shielding effect.

The present invention relates to a moldable nanocomposite for producing a transparent article made of a ceramic material, the moldable nanocomposite according to the present invention comprising: an organic binder; a powder of the ceramic material dispersed in the organic binder, the powder comprising particles having a diameter in the range from 5 nm to 700 nm, and / or a precursor of the ceramic material dispersed in the organic binder, the precursor being at least one metal-containing compound; and a phase-forming agent dispersed in the organic binder, the phase-forming agent being solid or viscous at room temperature and forming an internal phase in the organic binder, wherein the combined content of the powder and the precursor of the ceramic material in the moldable nanocomposite is at least 5 parts per volume based on 100 parts per volume of the organic binder, and wherein the moldable nanocomposite does not contain any low viscosity solvent. Further, the present invention relates to a method of producing a transparent article made of a ceramic material, the method according to the present invention making use of the moldable nanocomposite according to the present invention.

The invention relates to a foam material as well as a preparation method and application thereof. The preparation method comprises the following steps: (1) carrying out primary curing on a high internal phase emulsion to obtain a micro-shaped foam blank; (2) carrying out mechanical shaping on the micro-shaped foam blank body to obtain a special-shaped structure; and (3) carrying out secondary curing on the special-shaped structure to obtain the foam material, the primary curing is photocuring, and the secondary curing is photocuring or thermocuring. By utilizing connectivity and complexity of staggered sites of the HIPE fibers, differential initiators are respectively introduced into an oil phase and a water phase of the HIPE to carry out secondary curing. Through the step-by-step process of primary micro-shaping, special-shaped shaping and secondary complete curing, accurate regulation and control of the morphology of the high-internal-phase emulsion foam holes are realized, and the high-internal-phase emulsion foam holes can be changed into special-shaped structures such as ellipses and polygons from traditional circles.

The application discloses a high internal phase water-in-oil emulsion and application of the high internal phase water-in-oil emulsion as a fat substitute in salad dressing, and belongs to the technical field of fat substitutes. The preparation of the high internal phase water-in-oil emulsion comprises the following steps: dissolving dioscin and SP in chloroform, and then evaporating the chloroform to obtain DGSP particles; dispersing the prepared DGSP particles in rapeseed oil, and then dispersing a water phase drop by drop into the rapeseed oil to obtain a water-oil mixture, and then performing shearing emulsification to obtain W / O-HIPE. The oil gel-based W / O-HIPE with DGSP particles is used as a fat substitute to prepare a fat-reducing salad dressing, so that the fat-reducing salad dressing can have similar performance to normal salad dressing while reducing fat.

The invention relates to an injectable (not requiring pre-molding), biodegradable, and porous high internal phase emulsion composition prepared using solvent-free, photo- crosslinkable, low molecular weight, three-arm polycaprolactone methacrylate-based high internal phase emulsions (3PCLMA HIPE) for use as a bone graft, and to the method for preparing the same. The composition according to the invention is produced using the emulsion templating technique.

The invention provides a high internal phase emulsion, a preparation method thereof and an intelligent porous material. The high internal phase emulsion comprises an oil phase and a water phase, the oil phase comprises a pH / temperature-sensitive dual-responsive triblock copolymer, a polymeric monomer, a cross-linking agent and an initiator; the water phase comprises water, electrolyte and a pH regulator; the pH / temperature sensitive dual responsive triblock copolymer comprises a polyethylene glycol-polyacrylic acid-poly (N-isopropylacrylamide) triblock copolymer. According to the invention, the pH / temperature-sensitive dual-responsive triblock copolymer is introduced into the high internal phase emulsion as an emulsifier, and the triblock copolymer molecule can regulate and control the interface behavior through temperature, pH and ionic strength at the same time, so that the triblock copolymer is an ideal stabilizer for constructing intelligent W / O HIPE; the high-internal-phase emulsion provided by the invention has better stability, and the porous material prepared from the high-internal-phase emulsion has pH / temperature-sensitive synergistic responsiveness.

The invention discloses acrylic ester vitrimer foam as well as a preparation method and application of the acrylic ester vitrimer foam. The foam preparation method comprises the following steps: dropwise adding a water phase into an oil phase to prepare a high internal phase emulsion; the oil phase comprises an acrylate monomer, a surfactant, nanoparticles, an initiator, a cross-linking agent and a catalyst; the acrylate monomer comprises a hard monomer and a soft monomer, and the use amount of the hard monomer is 35-65%; the addition amount of the cross-linking agent is 2-6%; performing polymerization reaction on the high internal phase emulsion, and performing cross-linking heat treatment to obtain the foam. A dynamic covalent cross-linked structure is introduced into a vitrimer structure in the foam, so that the mechanical property of the acrylate foam is enhanced, and the foam is complete, free of collapse, good in morphology and relatively good in buffering performance. According to the method, the internal phase water can be removed through normal-pressure drying, the process bottleneck of special drying is broken through, the problem of cell collapse caused by surface tension in the process of removing the internal phase water through conventional normal-pressure drying is solved, the efficiency is high, and the cost is low.

The invention belongs to the field of drug sustained release preparations, and provides an ovulation inducing preparation for improving fertility and a preparation method thereof. The core-shell structure microsphere design is adopted, leuprorelin acetate is entrapped in the core of the polylactic acid microsphere, and covalently anchored amido bond connection is formed through an end group activated polylactic acid NHS ester intermediate and a chitosan-sodium tripolyphosphate ion network shell layer, so that the high stability of the shell layer is realized; by optimizing the compounding use of the internal phase stabilizer and the freeze-drying protective agent, the particle size distribution D50 of the microspheres is controlled to be 10-60 microns, the thickness of the shell layer is controlled to be 0.05-5 microns, and high encapsulation efficiency, good drug slow release performance and excellent storage stability are realized. The technical problems that in an existing peptide medicine core-shell microsphere system, a shell layer is prone to falling off, the medicine is suddenly released, and the stability is poor after freeze-drying are solved, and the peptide medicine core-shell microsphere has the advantages of being high in encapsulation efficiency, controllable in release and good in biocompatibility and has wide application value in the technical field of assisted reproduction.

The microcapsules according to the present invention are heat-resistant and shear-resistant, and each comprise a core material, a protein coating layer encapsulating the core material, and a wall material encapsulating the protein coating layer. The core material contains an oil or fat, and the wall material is formed by heat-curing a colloid. The microcapsules according to the present invention first encapsulate the oil or fat in the internal phase with the protein, thereby providing an internal environment that blocks moisture and oxygen. Furthermore, the endothermic phase change at the melting point is utilized to improve the viability and stability of the active substance during the heat treatment process. The wall material further protects the microcapsules, allowing them to have high stability and high-temperature resistance, as well as excellent shear resistance and acid resistance.

The present application relates to a method for preparing peanut protein microgel high internal phase emulsion with high antioxidant stability, the preparation method comprising: subjecting peanut protein isolate to enzymatic deamidation treatment to prepare deamidated peanut protein isolate; subjecting the deamidated peanut protein isolate to heat treatment to gel and then to high-pressure homogenization to obtain deamidated peanut protein isolate microgel particles; mixing the microgel particles with an alcohol solution of resveratrol, incubating, and then removing ethanol to construct a resveratrol-microgel particle compound; mixing the compound with vegetable oil and homogenizing to obtain a high internal phase Pickering emulsion. The emulsion prepared by the present application has excellent physical stability and antioxidant performance. The introduction of resveratrol significantly improves the free radical scavenging capacity and metal ion reducing capacity of the emulsion, and also endows the emulsion with good rheological properties, enabling it to exhibit clear structure and good self-supporting characteristics in food 3D printing. The present application can be applied in the fields of functional food, nutrition delivery system, and personalized food processing.

The application discloses a preparation method of a magnetic oil-absorbing resin based on a high internal phase emulsion template. First, a certain amount of magnetic nanoparticles, an initiator and a surfactant are added into a solution containing monomers, a crosslinking agent and a pore-forming agent, and after being uniformly mixed, an oil phase is obtained; then, under mechanical stirring, a calcium chloride aqueous solution is slowly added into the oil phase to obtain a water-in-oil high internal phase emulsion; then, a polymerization reaction is carried out at 70 DEG C for about 24 hours; after being extracted by anhydrous ethanol by means of a Soxhlet extractor and vacuum dried, the magnetic oil-absorbing resin is obtained. By adjusting the content of the magnetic nanoparticles, the pore structure and oil-absorbing performance of the magnetic oil-absorbing resin are optimized, and a series of magnetic oil-absorbing resins are prepared, which exhibit good oil-absorbing performance, magnetic response and recycling performance.

The application relates to a high internal phase emulsion ink material and a preparation method and application thereof, and belongs to the technical field of emulsion ink material preparation. The preparation method of the high internal phase emulsion ink material provided by the application is as follows: a pulse electric field is used to treat a soybean protein isolate solution, then the soybean protein isolate solution is mixed with a polysaccharide solution as an aqueous phase, then vegetable oil and a bioactive substance are mixed as an oil phase, and finally the aqueous phase and the oil phase are mixed and high-speed sheared to prepare the high internal phase emulsion ink material. The high internal phase emulsion ink material prepared by the application has high stability after freeze-thaw storage and high retention rate of the bioactive substance, can effectively embed the bioactive substance, better realizes slow release of the bioactive component, achieves the purpose of targeted transport, improves the retention capacity of the emulsion to the internal phase substance under the freeze-thaw condition, has great application prospect and development potential in the preparation of 3D printing functional food, and can provide a new technical direction and technical support for the 3D printing functional food.

The invention relates to a high-internal-phase bimodal emulsion for 3D printing and a preparation method and application thereof, the preparation method comprises the following steps: shearing, stirring and mixing a first high-internal-phase emulsion and a second high-internal-phase emulsion to obtain the high-internal-phase bimodal emulsion for 3D printing, the mode particle size of the first high internal phase emulsion is greater than the mode particle size of the second high internal phase emulsion. The high-internal-phase double-peak emulsion for 3D printing has self-stability, the structure for 3D printing is good in stability and high in precision, and the problems of structure collapse, deformation, layering, falling and the like are not prone to occurring.

The application discloses a kind of early strength agent for shotcrete and its preparation method, early strength agent prepared by silicon phase and calcium phase is used as internal phase oil phase with urea-based dispersant, water and polycarboxylic acid water reducing agent are mixed as external phase water phase, after sufficient reaction, early strength agent for shotcrete is obtained by centrifugal separation;Preparation method is specifically as follows: (1) urea-based superdispersant is prepared by free radical copolymerization reaction. (2) microfluidic chip is prepared by etching. (3) water phase and oil phase are pumped into chip respectively, and early strength agent is prepared after centrifugation. The application uses microfluidic technology, the preparation condition is mild, the production cost can be reduced, and the production is stable.

This invention relates to the field of food processing technology, and in particular to a highly stable high internal phase emulsion based on giant salamander mucus, its preparation method, and its application. The method includes the following steps: (1) mixing and stirring ascorbic acid solution and freeze-dried giant salamander mucus powder, centrifuging, and taking the supernatant as the aqueous phase of the high internal phase emulsion; (2) mixing the oil phase with the aqueous phase obtained in step (1), and homogenizing to obtain a highly stable high internal phase emulsion based on giant salamander mucus. The method of this invention is simple and mild, opening up new avenues for the high-value utilization of giant salamander aquaculture byproducts. The obtained high internal phase emulsion, due to its natural, stable nature and unique rheological properties, has broad application potential in the food industry, cosmetics, and pharmaceutical carrier fields.

The invention relates to a gelatin-based high internal phase emulsion as well as a preparation method and application thereof. The gelatin-based high internal phase emulsion comprises a water phase and an oil phase; the water phase is prepared from the following raw materials: gelatin, water, glutaraldehyde and a disulfide bond cross-linking agent; the preparation raw materials of the oil phase comprise liquid paraffin and a compound emulsifier. The gelatin-based high-internal-phase emulsion foam material prepared from the gelatin-based high-internal-phase emulsion provided by the invention has the advantages of high porosity, high pore structure connectivity, good structural stability and support performance, good biocompatibility, realization of digestion, and small influence of the digestion process and product on cell activity.

The invention relates to high-internal-phase emulsion foam as well as a preparation method and application thereof. The high-internal-phase emulsion foam is prepared from the following raw materials in percentage by mass: 0.1-10% of an oil-phase component and 90-99.9% of a water-phase component, the oil phase component comprises modified natural oil, an emulsifier and a cross-linking agent; the aqueous phase component includes an electrolyte, an aqueous solvent, and an initiator. According to the high-internal-phase emulsion foam provided by the invention, through collaborative design of food-grade raw materials, the prepared high-internal-phase emulsion foam has high stability and high foam functionality, and the high-internal-phase emulsion foam has 100% biocompatibility in a medical scene and has no toxic residues.

The present disclosure relates to compositions that are useful in the delivery of various materials. In particular, the compositions comprise a suspension wherein an internal phase material is surrounded by an external phase material. The internal phase specifically can be a hydrophilic material, and the external phase specifically can be a hydrophobic material. The materials are combined so that the internal phase is substantially encapsulated by the external phase such that release can be controlled in relation to osmotic pressure differentials. The suspension can be combined with a carrier, and various systems and products can be formed with the suspension and optional carrier, such as oral strips, spray delivery systems, smokeless tobacco products, aerosol delivery devices, cigarettes, and packaging.

The application provides a porous epoxy-based high internal phase emulsion based on a Pickering high internal phase emulsion method and a preparation method thereof, the porous epoxy-based high internal phase emulsion comprises a continuous phase and a dispersed phase, the continuous phase comprises bisphenol A type epoxy resin, a curing agent, a diluent and a dispersant, the dispersed phase comprises an alkaline silica sol aqueous solution, and the dispersant is a mixture of OP-10 and NP-4. The polymer formed by the high internal phase emulsion has a stable multi-level pore structure in the interior, and the structure has micrometer-level large pores and stable sub-micrometer-level small pores in the micrometer-level large pores, thereby forming a multi-level pore structure, and the multi-level pore structure has great application value in adsorption materials and catalytic materials.

This invention relates to the field of sealing grease technology, and more particularly to a high-performance, flame-retardant water-based shield tail sealing grease, its preparation method, and its application. The sealing grease comprises, by mass percentage: 10%–25% polyalphaolefin, 15%–30% polyisobutylene, 10%–25% sodium poly(isobutylene-alt-succinate), 10%–18% deionized water, 20%–30% filler, 1%–15% thickener, and 1%–3% reinforcing fibers. Specifically, the polyalphaolefin and polyisobutylene constitute a continuous oil phase, while the sodium poly(isobutylene-alt-succinate) dissolves or disperses in the deionized water and accumulates at the oil-water interface, allowing the deionized water to be stably dispersed as an internal phase, forming a water-in-oil structure. The sealing grease of this invention has moderate zero-point penetration, excellent pumpability, reliable sealing under 3.5MPa water pressure, good erosion resistance under both fresh and seawater conditions, and an ignition point of not less than 295℃. It also has excellent flame retardancy and environmental friendliness, and is suitable for shield tail sealing in long-distance, deep-buried and high-water-pressure shield tunnel construction.

The invention provides a porous material as well as a preparation method and application thereof, and belongs to the technical field of filtering materials. The preparation method provided by the invention comprises the following steps: mixing a monomer, a cross-linking agent, an emulsifier and a co-emulsifier to obtain a continuous phase; the monomer comprises a styrene monomer and an acrylate monomer; mixing an initiator, a stabilizer and water to obtain a dispersed phase; mixing the continuous phase and the dispersed phase to obtain a pre-emulsified emulsion; shearing the pre-emulsified emulsion to obtain a high internal phase emulsion; and carrying out polymerization reaction on the high internal phase emulsion to obtain the porous material. By controlling the mass fraction of the emulsifier in the continuous phase and the volume fraction of the dispersed phase in the pre-emulsified emulsion, the size of the dispersed phase liquid drops in the high internal phase emulsion is controlled, so that the porosity and the pore diameter of the porous material are adjustable, and the prepared porous material can be used as a centrifugal tube core and can be used as a centrifugal tube. Two technologies of centrifugal separation and size screening are integrated by utilizing an internal pore structure, so that more accurate and more efficient separation is realized.