108results about How to "Efficient killing" patented technology

This invention discloses a portable low-temperature plasma device based on a Laval nozzle structure and its application, belonging to the field of plasma technology application technology. Specifically, it includes (1) the construction of the device; and (2) the use of the device for fungal eradication treatment and transdermal drug delivery enhancement treatment. The beneficial effects achieved by this invention are as follows: This invention is the first to apply the Laval nozzle structure to a portable low-temperature plasma device. The results show that the device can effectively improve the plasma jet performance and active particle content, significantly improve the treatment effect of fungal infections of the skin and nails and the transdermal drug penetration efficiency, while solving the problems of large size, reliance on external power supply, and complex operation of traditional plasma devices. Therefore, using this invention for the treatment of fungal infections of the skin and nails and for enhanced transdermal drug delivery has advantages such as ease of operation, high safety, non-invasiveness, and high efficiency, and thus has potential application prospects in the field of skin disease treatment and transdermal drug delivery.

The application relates to the technical field of sewage treatment, and provides a plasma water circulation treatment system, which is characterized by comprising a water tank, a plasma generator, a fan and a pump; the water tank and the plasma generator are connected through pipelines to form a circulation loop; the fan is connected with the plasma generator; the pump is arranged in the pipeline and used for pumping water in the water tank into the plasma generator; a plurality of water level sensors are arranged in the water tank along the height direction of the water tank in sequence, and the water level sensors are used for detecting the water level of water in the water tank. The plasma water circulation treatment system adopts a plasma discharge mode to treat sewage, can effectively kill harmful microorganisms in the sewage, does not cause secondary pollution, improves the sewage treatment efficiency, and reduces the sewage treatment cost.

The invention provides a bacillus velezensis QT1 and an application of the bacillus velezensis QT1. The classification name of the bacillus velezensis is bacillus velezensis QT1, and the bacillus velezensis is preserved in the China Center for Type Culture Collection on November 12, 2025, the preservation address is Wuhan University, Wuhan, China, and the preservation number is CCTCC NO: M 20252531. The strain shows remarkable biological control efficiency, realizes effective control on various plant pathogens, and can prevent and treat tomato bacterial wilt and tea tree anthracnose. In addition, the bacillus velezensis QT1 can also effectively kill root-knot nematodes (especially meloidogyne incognita). When the strain is applied to plant cultivation, the growth of various pathogens can be remarkably inhibited, the health and yield of crops are improved, the strain is environment-friendly, the use of chemical pesticides is reduced, soil pollution is avoided, and the development requirement of sustainable agriculture is met.

This utility model relates to the field of hydroponics, specifically disclosing a mixing device for hydroponics substrates, including a mixing cylinder mechanism, a stirring mechanism, and a lifting mechanism. The mixing cylinder mechanism includes a mixing cylinder assembly, with an electric heating tube disposed within the inner wall interlayer of the mixing cylinder assembly. The stirring mechanism includes an upper cover plate assembly mounted on the mixing cylinder assembly, with a stirring component installed on the upper cover plate assembly. The lifting mechanism includes a support assembly, with a lifting component installed on the support assembly. This utility model achieves efficient mixing of the hydroponics substrate by driving the stirring rod to rotate via a motor, ensuring uniform distribution of substrate components. The electric heating tube in the inner wall interlayer can heat and sterilize the substrate, effectively killing harmful microorganisms in the substrate and improving the quality and safety of the substrate.

An antibody-drug conjugate, comprising a bispecific antibody targeting HER2 or an antigen-binding fragment thereof. Also provided are a preparation method for and an application of the antibody-drug conjugate, and a pharmaceutical composition comprising the antibody-drug conjugate. The antibody-drug conjugate can effectively kill tumors.

The application relates to a novel FSP1 degrading agent PROTAC compound and a preparation method and application thereof, and belongs to the technical field of medicinal chemistry. The novel FSP1 degrading agent PROTAC compound is a compound shown in formula I, a pharmaceutically acceptable salt of the compound shown in formula I, a hydrate of the compound shown in formula I or a solvate of the compound shown in formula I. The novel FSP1 degrading agent PROTAC compound provided in the application has the activity of degrading ferroptosis inhibitor 1 (FSP1).

This invention belongs to the technical field of traditional Chinese medicine extraction equipment, specifically relating to an automated sterilization process for the entire pipeline of traditional Chinese veterinary medicine extraction. This application modifies the entire pipeline of traditional Chinese veterinary medicine extraction to meet the requirements of high-temperature and high-pressure steam sterilization. Before the extraction of traditional Chinese veterinary medicine, high-temperature and high-pressure steam is used to sterilize the entire pipeline. Then, the extraction temperature in the extraction tank is controlled to ensure the sterilization of the extract, thereby ensuring that the final oral liquid meets the sterilization requirements. This saves on the terminal sterilization process and allows for direct filling with non-high-temperature resistant packaging, greatly saving manufacturing costs.

The invention discloses a drug-loaded nanoparticle as well as a preparation method and application thereof. The drug-loaded nanoparticle can be used for treating triple negative breast cancer, and specifically comprises a magnetic nanoparticle, an active component loaded in the magnetic nanoparticle, and an erythrocyte membrane coating the magnetic nanoparticle, wherein the active ingredients are selected from one or more of piperlongumine, polyphyllin II, erianin, pseudolaric acid, 6-gingerol, ginkgetin, solasonine, cucurbitacine B and lycorine. In practical application, the drug-loaded nanoparticles have good biological safety, long circulation capability and high tumor retention capability, and can generate efficient killing and treatment effects on triple-negative breast cancer by inducing cell apoptosis.

The invention belongs to the technical field of nano-catalyst antibiosis, and particularly relates to a zinc-based nitrogen-doped carbon-loaded metal palladium nano-enzyme as well as a preparation method and application thereof. The ZnNC-loaded metal palladium nano-enzyme is prepared by adopting a deposition-precipitation method which is simple to operate, taking ZnNC as a carrier and taking metal palladium nano-particles as an active center. The nano-enzyme has excellent oxidase-like activity, can catalyze O2 to generate hydroxyl free radicals (. OH), singlet oxygen (< 1 > O2) and superoxide anion free radicals (O2 <->) so as to kill bacteria and achieve an antibacterial effect, and has a remarkable antibacterial effect on escherichia coli under an acidic condition.

This invention belongs to the field of oral care technology and provides a bismuth microsphere oral care agent that eliminates halitosis and has anti-inflammatory and antibacterial properties. The agent comprises a bismuth complex, wherein the bismuth complex is a porous bismuth microsphere selected from Bi2O2CO3 and Bi2O2CO3@Bi2S3 heterojunctions. This oral care agent can rapidly respond to the high expression of H2S in periodontitis, eliminating halitosis, inhibiting inflammation, and regulating the periodontal microenvironment. Simultaneously, the (Bi2O2CO3) microspheres react with H2S to form Bi2O2CO3@Bi2S3 heterojunctions in situ, which can efficiently kill bacteria under light irradiation.

The utility model relates to an intelligent toilet lid and an intelligent toilet. The intelligent toilet lid comprises a machine core base and a plasma generator. Wherein the machine core seat is used for covering a toilet seat, and a cavity is formed in the machine core seat; the plasma generator is arranged in the cavity and used for generating plasma. Plasma generated by the plasma generator has strong oxidizability and can effectively kill bacteria, viruses and molds. The gas containing ions and free electrons is diffused in the cavity of the machine core seat and can sterilize and disinfect the cavity of the whole machine core seat and components such as a circuit assembly in the cavity, and the plasma has a continuous sterilization effect on the cavity, so that mould breeding caused by a humid environment can be prevented, and the service life of the machine core seat is prolonged. Therefore, electrical elements in the machine core seat are prevented from being aged due to bacterial or mould erosion, and the service life is prolonged.

This invention relates to a T-cell receptor capable of binding to the HPV16 E6 antigen presented by the HLA-C*14:02 molecule. The T-cell receptor comprises: αCDR1 (amino acid sequence as shown in SEQ ID NO:1), αCDR2 (amino acid sequence as shown in SEQ ID NO:3), αCDR3 (amino acid sequence as shown in SEQ ID NO:5), βCDR1 (amino acid sequence as shown in SEQ ID NO:11), βCDR2 (amino acid sequence as shown in SEQ ID NO:13), and βCDR3 (amino acid sequence as shown in SEQ ID NO:15). This invention provides a novel and precise immunotherapy strategy for patients with HLA-C*14:02 genotype HPV-related cervical cancer, significantly expanding the applicable population for TCR-T therapy.

The application provides application of glutaroyl-CoA dehydrogenase in inducing ferroptosis of liver cancer cells, and belongs to the technical field of biotechnology.The application provides application of glutaroyl-CoA dehydrogenase (GCDH) in preparing products for evaluating risk of liver cancer and evaluating prognosis risk of liver cancer, and the tumor stage and T grade can be estimated by detecting the expression amount of GCDH, and the survival effect of liver cancer patients is evaluated.The application provides application of the overexpression reagent of GCDH in preparing products for inhibiting proliferation of liver cancer cells and inducing ferroptosis of liver cancer cells, and the ferroptosis of liver cancer cells is promoted by overexpressing GCDH in cells, and the colony formation ability of liver cancer cells is reduced.Further, the application provides application of the overexpression reagent of GCDH combined with a CA9 inhibitor in preparing products for inhibiting proliferation of liver cancer cells.

This utility model discloses a dual-mode ultrasonic therapy device, including a housing. A therapy device is fixedly installed on the bottom inner side of the housing. A first support plate is fixedly installed on one side of the therapy device. A pair of treatment heads are positioned above the first support plate. A set of ventilation plates are symmetrically installed on the outer side of the housing. Ventilation slots are formed on both sides of the housing. A semi-circular plate is fixedly installed in the middle of the outer front end of the housing, with a circular groove below the semi-circular plate. The installation of the ventilation slots and ventilation plates ensures both air permeability and dust prevention, improving the overall safety of the device. The installation of the semi-circular plate and circular groove ensures both effective closure and stability when the device is closed, preventing it from easily falling off and further enhancing the user experience.

The application discloses a preparation method and application of a hollow manganese dioxide nanocarrier coated with a human umbilical cord mesenchymal stem cell membrane and a transmembrane peptide TAT, and is characterized in that: hollow mesoporous manganese dioxide is synthesized through a selective etching technology, and a layer of human umbilical cord mesenchymal stem cell membrane is coated outside the manganese dioxide through a repeated extrusion method. Since the cell membrane has special tumor homing characteristics, and lacks major histocompatibility complex-II and only expresses major histocompatibility complex-I in a trace amount, the key scientific problems and difficulties such as low biological safety, strong immunogenicity and easy elimination by the body of artificially synthesized nanomaterials can be effectively solved. Finally, the cell membrane surface is modified with the transmembrane peptide TAT through a phospholipid insertion method, precise subcellular localization-nucleus targeting is realized, and tumor cells can be more effectively killed.

The utility model discloses a campus direct drinking machine with an efficient sterilization function, and relates to the field of direct drinking machines, the campus direct drinking machine with the efficient sterilization function comprises a shell, a filtering system, a heat exchanger, a hot tank and a range extending water tank are installed in the shell, and the liquid outlet end of the filtering system is connected with a cold fluid inlet of the heat exchanger; according to the campus direct drinking machine with the efficient sterilization function, the range-extending water tank is large in water storage space, multiple external water outlets are connected with multiple faucets, water can be stably supplied when teachers and students use water in a centralized mode in a campus, the problem that water is insufficient when multiple faucets of a traditional direct drinking machine are started at the same time is solved, and the water use requirement of a crowded place is met. Meanwhile, a closed-loop sterilization system is formed through a filtering system, a hot tank, an overflowing type uv sterilization lamp, a correlation uv lamp in a range extending water tank and silver ions at a water nozzle, microorganisms in water are efficiently killed, the safety of drinking water is guaranteed, and the health of teachers and students is protected.

This invention provides a road base material based on sludge and construction waste, its preparation method, and its application. The road base material includes a base component and an admixture component. The base component includes: 45-55% recycled coarse aggregate, 20-35% recycled fine aggregate, 15-25% sludge, 4-6% cement, and 1-4% water. Both the recycled coarse and fine aggregates are derived from construction waste. The admixture component includes quicklime, sodium hydroxide, and zinc ricinoleate. The mass percentage of quicklime to sludge is 4-8%, the mass percentage of sodium hydroxide to sludge is 0.1-0.2%, and the mass percentage of zinc ricinoleate to sludge is 0.2-0.5%. This invention promotes the high-value utilization of urban solid waste such as sludge and construction waste, and yields a higher-performance road base material based on sludge and construction waste.

The invention relates to the technical field of immunity, in particular to a nano antibody specifically combined with CD276 and application of the nano antibody. The preparation method comprises the following steps: immunizing alpaca by adopting human CD276 antigen protein to obtain peripheral blood PBMC (peripheral blood mononuclear cell), then calling a nano antibody gene, establishing a phage library, finally obtaining an antibody sequence with relatively high antigen affinity respectively through a single B cell antibody screening technology and a phage library screening technology, and then applying the found antibody sequence to CAR-T to obtain a CAR-T antibody sequence with relatively high antigen affinity. Animal in-vivo and in-vitro drug effects show that the obtained antibody sequence is suitable for various solid tumor indications and has a remarkable anti-tumor effect on lung cancer, colorectal cancer and pancreatic cancer. The antibody sequence can be applied to development of antibody drugs, cell therapy drugs, ADC drugs and the like.

This invention provides a method for controlling Spartina alterniflora and promoting natural mangrove restoration based on rolling mulching and in-situ mud slurry, belonging to the field of ecological control technology. The method involves mechanically rolling Spartina alterniflora to flatten most of it and press it into the tidal flat soil. Then, a biodegradable mulch film is laid on top, and mud slurry is extracted and applied to form a mud slurry cover layer. A mangrove seed interception and planting device is then installed on the mud slurry cover layer to prevent mangrove seeds from growing naturally, thereby reducing the cost of Spartina alterniflora control and improving the efficiency of Spartina alterniflora control.

The utility model discloses a waste bamboo wood sterilizing and smashing processing device which comprises a smashing mechanism, a sterilizing mechanism is arranged on one side of the smashing mechanism, a conveying mechanism is arranged between the smashing mechanism and the sterilizing mechanism, the smashing mechanism comprises a supporting table, a smashing bin, a double-roller smashing machine and a discharging port, the smashing bin is fixedly arranged at the upper end of the supporting table, and the discharging port is fixedly arranged at the lower end of the supporting table. And a double-roller crusher is fixedly arranged at the lower end of the crushing bin. According to the utility model, the crushing process is added before the sterilization process, so that bamboo wood can be crushed and then is subjected to steam sterilization and cooking more conveniently, the particle size is greatly reduced after the bamboo wood is crushed, steam can permeate into the bamboo wood more quickly and uniformly, each part is ensured to be in full contact with high-temperature steam, and the quality of the bamboo wood is improved. And internal bacteria, molds and microorganisms are effectively killed. And compared with large bamboo materials, the surface area of crushed particles is increased, steam contact is more sufficient, and the sterilization efficiency is remarkably improved.

The invention discloses an extraction process of citrus essential oil and the citrus essential oil prepared through the extraction process, and belongs to the field of natural perfume extraction.The extraction process of the citrus essential oil comprises the following steps that S1, peel of disinfected and cleaned fresh citrus fruits is obtained; s2, sequentially crushing and squeezing the fruit peels under the assistance of ultrasonic waves or without ultrasonic waves, and then separating out solid matters to obtain virgin juice; and S3, standing and layering the virgin juice in an environment of 0-10 DEG C, then centrifuging at a controlled temperature at a centrifugal speed of 2000-60000r / min for 1-180min, and separating out upper-layer essential oil within 30min after centrifugation is finished, so as to obtain the citrus essential oil. The process can improve the essential oil yield, reduce the water content and maintain the natural fragrance close to that of fresh fruits, and can be applied to the field of food and the field of daily chemicals.

The invention discloses a fabric acarus killing instrument based on the synergistic effect of ultrasonic atomization and high-frequency vibration, and the acarus killing instrument comprises an acarus killing instrument host which is provided with a rolling brush, a fan and a power supply board; the chemical acarus killing module comprises an agent bin and an ultrasonic sheet, the agent bin is fixedly installed on the acarus killing instrument main machine, an agent is arranged in the agent bin and comprises tea tree essential oil, folium eucalypti essential oil and water, the adding proportion of the tea tree essential oil, the folium eucalypti essential oil and the water in the agent is 1: 1: 4, and the agent bin supplies the agent to the ultrasonic sheet through a liquid supply pipeline; the ultrasonic piece is connected with the power supply board through a wire, and atomization holes corresponding to the ultrasonic piece in position are formed in a bottom shell of the mite killing instrument host. Compared with the prior art, the problems that an existing mite killing instrument is single in mite killing mode and not thorough in mite killing are solved.

The invention discloses a reverse osmosis membrane chemical cleaning method aiming at organic and microorganism composite sewage plugging. According to the method, the cleaning sequence of'alkali first, sterilization second and acid second 'is adopted, organic sewage blocking substances and biological membranes serving as pollution matrixes are removed preferentially, wrapped inorganic scales and microorganisms are fully exposed, and the reaction efficiency of subsequent sterilization and descaling agents is remarkably improved. The method provided by the invention can effectively recover the membrane flux and desalination rate, significantly reduce the system operation pressure difference and prolong the service life of the membrane element, and is especially suitable for reverse osmosis systems such as urban reclaimed water, closed lake water and the like which are easy to generate organic and microorganism composite sewage blockage.

The utility model relates to the technical field of vegetable product treatment, and discloses vegetable product nutritional ingredient stabilizing treatment equipment which comprises a cleaning frame, a fixing plate is fixedly connected to the top of the cleaning frame, a cleaning assembly used for decontaminating the cleaning frame is fixedly connected to the interior of the cleaning frame, a first motor is fixedly connected to the top of the fixing plate, and a second motor is fixedly connected to the top of the fixing plate. The driving end of the first motor is fixedly connected with an elliptic column, the top of the fixing plate is fixedly connected with a connecting column, the interior of the connecting column is slidably connected with a sliding column, the interior of the sliding column is rotatably connected with an extrusion column, the interior of the sliding column is fixedly connected with a spring, and the exterior of the extrusion column is fixedly connected with a rotating rod. According to the vegetable product quantitative feeding device, accurate quantitative feeding is guaranteed, quantitative feeding treatment on vegetable products is achieved, harmful microorganisms on the surfaces and in the vegetable products can be effectively killed, the number and activity of the microorganisms are reduced, and the spoilage speed of the vegetable products is slowed down.

The invention discloses mussel-imitating bacteria responsive injectable hydrogel as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. The hydrogel is formed by compounding a mussel-imitating viscous hydrogel bracket and a bacterial response agent, the viscous hydrogel scaffold is QCS-EC (Quaternized Chitosan) and is formed by non-covalent binding of QCS (Quaternized Chitosan) and EGCG (Epigallocatechin Gallate); the bacterial response agent is a supramolecular nano cross-linked compound TEBox-B12, and is formed by self-assembly of box-shaped quaternized pyridine heterocyclic organic salt molecules TEBox and salt containing suprachaotropic liquid anions B12H12-through hydrogen bonds and electrostatic interaction. The hydrogel disclosed by the invention has NIR-II photo-thermal and photodynamic antibacterial treatment functions, and can be used for efficiently killing bacteria in deep tissues; the hydrogel also has high adhesion, good biocompatibility and injectability, is strong in convenience and applicability, can provide a good healing environment for wounds, promotes fibroblast proliferation and migration, accelerates wound tissue regeneration and healing processes, and reduces scar formation.

The application provides application of a coumarin compound in prevention and treatment of citrus Huanglongbing or killing of psyllospora citri, and belongs to the technical field of plant disease prevention and treatment. The application takes the citrus Huanglongbing medium pest psyllospora citri as a research object, systematically evaluates biological activity of the coumarin compound on the psyllospora citri, and the result shows that the coumarin compound can effectively kill the psyllospora citri. The application not only provides more choices for the plant source pesticide with good prevention and treatment effect on the psyllospora citri, but also has reference significance for formulating a field resistance management strategy of the psyllospora citri, simultaneously provides a train of thought for developing a high-efficiency prevention and treatment technology of the psyllospora citri, and therefore has important theoretical significance and application prospect.

The application discloses application of dimethoxyphenol and a biological preparation thereof in plant pathogenic nematode control, and aims to solve the problems of single function, unknown active ingredient, unclear mechanism and unstable quality of existing microbial source preparations. The application accurately identifies 2,3-dimethoxyphenol as an important nematicidal active substance through metabolomics, and realizes stable co-accumulation of 2,3-dimethoxyphenol and a growth-promoting factor, isopentenyladenine, by combining with a specific strain (pink helical polysporal mold NF-06 and bacillus velezensis YB-1652) co-culture process, so that technical effects of clear composition, synergistic disease-preventing and growth-promoting function, controllable quality and environment friendliness are achieved.

The invention relates to the technical field of diatom ooze decorative plates, in particular to a fireproof and antibacterial diatom ooze decorative plate and a preparation method thereof.The fireproof and antibacterial diatom ooze decorative plate comprises a base material layer, a decorative layer and a fireproof and antibacterial coating which are sequentially arranged from bottom to top; the fireproof and antibacterial coating comprises the following raw materials in parts by weight: 3-6 parts of nano silicon dioxide, 6-10 parts of methacryloyloxyethyl hexadecyl dimethyl ammonium chloride, 20-30 parts of 2-hydroxyethyl methacrylate phosphate, 5-10 parts of [(6-oxo-6H-dibenzo [C, E] [1, 2, 3] triazolo [3, 4-b] pyrimidine-2-yl)-1, 2, 3-triazolo [ The invention relates to a UV (ultraviolet) photoinitiator, which is prepared from the following components in parts by weight: 10 to 20 parts of 2, 2] oxophosphahexane-6-yl) methyl] succinic acid bis (2-hydroxyethyl) ester, 80 to 100 parts of polyurethane acrylate resin, 3 to 5 parts of photoinitiator and 20 to 40 parts of organic solvent. According to the fireproof and antibacterial diatom ooze decorative plate and the preparation method thereof, on the premise of ensuring the mechanical strength, the fireproof and antibacterial diatom ooze decorative plate not only has an excellent decorative effect, but also has fireproof performance and antibacterial performance at the same time.

The application relates to the field of waste plastic resource utilization, and discloses a composite material with antibacterial performance and a preparation method and application thereof, the composite material comprising a crosslinked polymer and a nano metal loaded on the crosslinked polymer, wherein the crosslinked polymer is a product of crosslinked structure crosslinking of halogen-containing plastic, the structural formula of the crosslinked structure is shown as formula a, and the nano metal comprises at least one of silver, copper, zinc and aluminum, wherein m and n are each independently 1-6. The composite material provided by the application can be prepared by using waste halogen-containing plastic and cheap metal, raw material sources are wide, the cost is low, the process is simple, the operation difficulty is low, the composite material has excellent antibacterial performance and can promote wound healing, that is, the composite material provided by the application can realize safe dehalogenation of halogen-containing waste plastic while simply and efficiently synthesizing an antibacterial material, and realizes resource utilization and high-value utilization of waste halogen-containing plastic.

This invention discloses a method for biotechnology-based conversion of livestock and poultry manure into animal feed, belonging to the field of agricultural waste resource utilization. The method includes: solid-liquid separation and crushing of livestock and poultry manure, adjusting the moisture content to 65%~75%; applying a pulsed electric field to treat the manure, resulting in a microbial cell breakage rate ≥70% and a cellulose crystallinity reduction ≥15%; adding a complex enzyme preparation composed of laccase, manganese peroxidase, xylanase, and lysozyme for enzymatic hydrolysis; after cooling, inoculating a mixed flora of thermophilic Bacillus stearothermophilus and Kluyveromyces martensii acclimated with sodium acetate and phenol; conducting a two-stage fermentation, with an aerobic stage followed by closed, static fermentation; and finally, low-temperature vacuum drying and pulverization to obtain feed protein powder. This invention, through the synergistic effect of pulsed electric field, complex enzyme, and acclimated microbial flora, achieves efficient, safe, and rapid feed utilization of livestock and poultry manure, with a total processing time ≤72 hours, a crude protein content of 28%~35%, and antibiotic residue ≤0.2 mg / kg.