147results about How to "Efficient killing" patented technology

The minced fillet is used as a raw material to produce the protein jelly food, and the product is rich in high-quality protein and high in nutritional value. A physical fishy smell removing method and a biological fishy smell removing method are combined, so that the fishy smell of the minced fillet is effectively removed. 50-100 parts of pigskin and 100 parts of minced fillet are jointly gelatinized to form binary protein gel, so that on one hand, the gel strength of the prepared product is improved, and meanwhile, the melting point of the product is improved. Besides, a microwave technology (the microwave power is 0.5-20kW and the treatment time is 60-600s) is adopted to combine a thermally induced gelation process and a sterilization process into one, so that microorganisms are effectively killed while the gelation process is realized. The fishy smell-removed minced fillet-pigskin protein jelly food with high gel strength can be obtained, and the food has a soft and elastic texture, a fine taste and extremely high nutritional value of fish meat, can be stored at normal temperature for a long time, can be directly eaten after being unsealed, and can also be shredded, sliced and seasoned for eating.

This invention discloses a portable low-temperature plasma device based on a Laval nozzle structure and its application, belonging to the field of plasma technology application technology. Specifically, it includes (1) the construction of the device; and (2) the use of the device for fungal eradication treatment and transdermal drug delivery enhancement treatment. The beneficial effects achieved by this invention are as follows: This invention is the first to apply the Laval nozzle structure to a portable low-temperature plasma device. The results show that the device can effectively improve the plasma jet performance and active particle content, significantly improve the treatment effect of fungal infections of the skin and nails and the transdermal drug penetration efficiency, while solving the problems of large size, reliance on external power supply, and complex operation of traditional plasma devices. Therefore, using this invention for the treatment of fungal infections of the skin and nails and for enhanced transdermal drug delivery has advantages such as ease of operation, high safety, non-invasiveness, and high efficiency, and thus has potential application prospects in the field of skin disease treatment and transdermal drug delivery.

The utility model relates to the technical field of diseased animal isolation, and discloses a diseased animal isolation cage which comprises a fixing structure movably installed at the top end of a device base, the output end of a water pump is fixedly connected with a connecting pipe, a hose is rotatably inserted into the bottom end of the inner wall of the connecting pipe, and a motor is installed at the other end of the top end of a top plate. The output end of the motor is fixedly connected with a second bevel gear, the surface of the second bevel gear is fixedly sleeved with a first bevel gear, filtering holes are formed in the surface of the device base, a movable drawer is slidably inserted into the device base, and a collecting box is slidably inserted into the front face of the device base. Through cooperative arrangement of a first bevel gear, a second bevel gear, a connecting plate, a hose and a spraying head, breeding personnel can conveniently disinfect and spray medicine to sick livestock, so that pathogens can be effectively killed, the sick livestock is prevented from infecting other livestock, and manual operation can be reduced.

The application relates to the technical field of sewage treatment, and provides a plasma water circulation treatment system, which is characterized by comprising a water tank, a plasma generator, a fan and a pump; the water tank and the plasma generator are connected through pipelines to form a circulation loop; the fan is connected with the plasma generator; the pump is arranged in the pipeline and used for pumping water in the water tank into the plasma generator; a plurality of water level sensors are arranged in the water tank along the height direction of the water tank in sequence, and the water level sensors are used for detecting the water level of water in the water tank. The plasma water circulation treatment system adopts a plasma discharge mode to treat sewage, can effectively kill harmful microorganisms in the sewage, does not cause secondary pollution, improves the sewage treatment efficiency, and reduces the sewage treatment cost.

The invention discloses a preparation method and application of a novel carboline quaternary ammonium salt compound with a photodynamic antibacterial effect. According to the novel carboline quaternary ammonium salt compound disclosed by the invention, a triphenylamine group is introduced to a carboline parent nucleus, so that the fluorescence intensity of the compound is effectively reduced, after illumination, energy passes through systems to induce the generation of ROS, and the photodynamic effect of the carboline compound is improved. Meanwhile, the novel carboline quaternary ammonium salt compound disclosed by the invention can target the surface with high negative charges of bacteria due to the existence of quaternary ammonium salt groups, and bacteria and drug-resistant bacteria can be effectively killed after illumination is applied. Therefore, the novel carboline compound provided by the invention can be applied to the field of medicines and is used for preparing antibacterial medicines.

The invention provides a bacillus velezensis QT1 and an application of the bacillus velezensis QT1. The classification name of the bacillus velezensis is bacillus velezensis QT1, and the bacillus velezensis is preserved in the China Center for Type Culture Collection on November 12, 2025, the preservation address is Wuhan University, Wuhan, China, and the preservation number is CCTCC NO: M 20252531. The strain shows remarkable biological control efficiency, realizes effective control on various plant pathogens, and can prevent and treat tomato bacterial wilt and tea tree anthracnose. In addition, the bacillus velezensis QT1 can also effectively kill root-knot nematodes (especially meloidogyne incognita). When the strain is applied to plant cultivation, the growth of various pathogens can be remarkably inhibited, the health and yield of crops are improved, the strain is environment-friendly, the use of chemical pesticides is reduced, soil pollution is avoided, and the development requirement of sustainable agriculture is met.

The jelly food is produced by using the whole fish meat as the raw material, and the product is rich in high-quality protein, EPA, DHA, collagen and mucopolysaccharide, and has extremely high nutritional value of the whole fish meat. Physical fishy smell removal of ginger, garlic and cooking wine is utilized, meanwhile, 5-10 parts of fresh yeast and 5-10 parts of soybean cakes are used for preparing fishy smell removal liquid, biological fishy smell removal is conducted on 100 parts of whole fish meat, and the fishy smell of the fish meat is effectively removed. By adding tea polyphenol, the gel strength and elasticity of the product are improved, and meanwhile, the stability of the product quality is effectively improved. The microwave technology is adopted to combine a thermally induced gelation process and a sterilization process, the microwave power is 0.5-20 kW, the treatment time is 60-600 s, the gelation process is achieved, and microorganisms are effectively killed. According to the invention, the fishy-smell-removed freshwater fish jelly can be obtained, and the leisure food has soft, crisp and tender texture, fine and smooth taste, high protein and low fat, has extremely high nutritional value of whole fish meat, and can be stored for a long time at normal temperature.

This utility model relates to the field of hydroponics, specifically disclosing a mixing device for hydroponics substrates, including a mixing cylinder mechanism, a stirring mechanism, and a lifting mechanism. The mixing cylinder mechanism includes a mixing cylinder assembly, with an electric heating tube disposed within the inner wall interlayer of the mixing cylinder assembly. The stirring mechanism includes an upper cover plate assembly mounted on the mixing cylinder assembly, with a stirring component installed on the upper cover plate assembly. The lifting mechanism includes a support assembly, with a lifting component installed on the support assembly. This utility model achieves efficient mixing of the hydroponics substrate by driving the stirring rod to rotate via a motor, ensuring uniform distribution of substrate components. The electric heating tube in the inner wall interlayer can heat and sterilize the substrate, effectively killing harmful microorganisms in the substrate and improving the quality and safety of the substrate.

An antibody-drug conjugate, comprising a bispecific antibody targeting HER2 or an antigen-binding fragment thereof. Also provided are a preparation method for and an application of the antibody-drug conjugate, and a pharmaceutical composition comprising the antibody-drug conjugate. The antibody-drug conjugate can effectively kill tumors.

The invention discloses a small molecular monomer containing azobenzene and ferrocenyl as well as a synthesis method and application thereof, and the synthesis method comprises the following steps: step 1, obtaining alkynyl functionalized azobenzene from 4, 4 '-dihydroxyazobenzene; step 2, carrying out a click reaction on the ferrocenecarboxylic acid-3-azidopropyl ester and the alkynyl functionalized azobenzene through CuAAC, so as to obtain ferrocene functionalized azobenzene; and 3, carrying out a substitution reaction on methacryloyl chloride and ferrocenyl functionalized azobenzene to obtain the small molecular monomer containing azobenzene and ferrocenyl. The synthesized monomer can be conveniently copolymerized with other functional monomers, so that a water-soluble polymer with a clear and uniform structure is obtained. The polymer can be used as a Fenton reagent, efficiently kills tumor cells through an oxidative stress mechanism, and is applied to chemodynamic therapy of tumors.

The application relates to a novel FSP1 degrading agent PROTAC compound and a preparation method and application thereof, and belongs to the technical field of medicinal chemistry. The novel FSP1 degrading agent PROTAC compound is a compound shown in formula I, a pharmaceutically acceptable salt of the compound shown in formula I, a hydrate of the compound shown in formula I or a solvate of the compound shown in formula I. The novel FSP1 degrading agent PROTAC compound provided in the application has the activity of degrading ferroptosis inhibitor 1 (FSP1).

This invention belongs to the technical field of traditional Chinese medicine extraction equipment, specifically relating to an automated sterilization process for the entire pipeline of traditional Chinese veterinary medicine extraction. This application modifies the entire pipeline of traditional Chinese veterinary medicine extraction to meet the requirements of high-temperature and high-pressure steam sterilization. Before the extraction of traditional Chinese veterinary medicine, high-temperature and high-pressure steam is used to sterilize the entire pipeline. Then, the extraction temperature in the extraction tank is controlled to ensure the sterilization of the extract, thereby ensuring that the final oral liquid meets the sterilization requirements. This saves on the terminal sterilization process and allows for direct filling with non-high-temperature resistant packaging, greatly saving manufacturing costs.

The present invention discloses a multi-stage treatment device for high-concentration organic wastewater, which belongs to the technical field of light-irradiated wastewater treatment, and comprises a shell, wherein a rotating shaft is rotatably connected to the shell through a sealed bearing, a first spiral blade is fixedly connected to the rotating shaft, and an ultraviolet emitting element is fixedly connected to the lower surface of the upper wall of the shell; a liquid storage tank is provided above the shell, and the liquid storage tank is connected to the shell; a gas tank is provided on the lower side of the shell, and the gas tank is connected to the shell. The design of the rotating shaft and the first spiral blade of the invention not only improves the mixing efficiency of the chemical agent in the wastewater, but also enables the agent to be quickly and evenly dispersed into the wastewater, thereby improving the treatment effect; at the same time, the rotation of the spiral blade can also drive the wastewater to form an upward and downward flow, so that the organic matter in the wastewater can be more fully in contact with the chemical agent and dissolved oxygen, further improving the treatment efficiency. In combination with the ultraviolet emitting element, the wastewater can be fully sterilized.

The invention discloses a drug-loaded nanoparticle as well as a preparation method and application thereof. The drug-loaded nanoparticle can be used for treating triple negative breast cancer, and specifically comprises a magnetic nanoparticle, an active component loaded in the magnetic nanoparticle, and an erythrocyte membrane coating the magnetic nanoparticle, wherein the active ingredients are selected from one or more of piperlongumine, polyphyllin II, erianin, pseudolaric acid, 6-gingerol, ginkgetin, solasonine, cucurbitacine B and lycorine. In practical application, the drug-loaded nanoparticles have good biological safety, long circulation capability and high tumor retention capability, and can generate efficient killing and treatment effects on triple-negative breast cancer by inducing cell apoptosis.

The invention belongs to the technical field of nano-catalyst antibiosis, and particularly relates to a zinc-based nitrogen-doped carbon-loaded metal palladium nano-enzyme as well as a preparation method and application thereof. The ZnNC-loaded metal palladium nano-enzyme is prepared by adopting a deposition-precipitation method which is simple to operate, taking ZnNC as a carrier and taking metal palladium nano-particles as an active center. The nano-enzyme has excellent oxidase-like activity, can catalyze O2 to generate hydroxyl free radicals (. OH), singlet oxygen (< 1 > O2) and superoxide anion free radicals (O2 <->) so as to kill bacteria and achieve an antibacterial effect, and has a remarkable antibacterial effect on escherichia coli under an acidic condition.

This invention belongs to the field of oral care technology and provides a bismuth microsphere oral care agent that eliminates halitosis and has anti-inflammatory and antibacterial properties. The agent comprises a bismuth complex, wherein the bismuth complex is a porous bismuth microsphere selected from Bi2O2CO3 and Bi2O2CO3@Bi2S3 heterojunctions. This oral care agent can rapidly respond to the high expression of H2S in periodontitis, eliminating halitosis, inhibiting inflammation, and regulating the periodontal microenvironment. Simultaneously, the (Bi2O2CO3) microspheres react with H2S to form Bi2O2CO3@Bi2S3 heterojunctions in situ, which can efficiently kill bacteria under light irradiation.

The utility model relates to an intelligent toilet lid and an intelligent toilet. The intelligent toilet lid comprises a machine core base and a plasma generator. Wherein the machine core seat is used for covering a toilet seat, and a cavity is formed in the machine core seat; the plasma generator is arranged in the cavity and used for generating plasma. Plasma generated by the plasma generator has strong oxidizability and can effectively kill bacteria, viruses and molds. The gas containing ions and free electrons is diffused in the cavity of the machine core seat and can sterilize and disinfect the cavity of the whole machine core seat and components such as a circuit assembly in the cavity, and the plasma has a continuous sterilization effect on the cavity, so that mould breeding caused by a humid environment can be prevented, and the service life of the machine core seat is prolonged. Therefore, electrical elements in the machine core seat are prevented from being aged due to bacterial or mould erosion, and the service life is prolonged.

This invention relates to a T-cell receptor capable of binding to the HPV16 E6 antigen presented by the HLA-C*14:02 molecule. The T-cell receptor comprises: αCDR1 (amino acid sequence as shown in SEQ ID NO:1), αCDR2 (amino acid sequence as shown in SEQ ID NO:3), αCDR3 (amino acid sequence as shown in SEQ ID NO:5), βCDR1 (amino acid sequence as shown in SEQ ID NO:11), βCDR2 (amino acid sequence as shown in SEQ ID NO:13), and βCDR3 (amino acid sequence as shown in SEQ ID NO:15). This invention provides a novel and precise immunotherapy strategy for patients with HLA-C*14:02 genotype HPV-related cervical cancer, significantly expanding the applicable population for TCR-T therapy.

The application provides application of glutaroyl-CoA dehydrogenase in inducing ferroptosis of liver cancer cells, and belongs to the technical field of biotechnology.The application provides application of glutaroyl-CoA dehydrogenase (GCDH) in preparing products for evaluating risk of liver cancer and evaluating prognosis risk of liver cancer, and the tumor stage and T grade can be estimated by detecting the expression amount of GCDH, and the survival effect of liver cancer patients is evaluated.The application provides application of the overexpression reagent of GCDH in preparing products for inhibiting proliferation of liver cancer cells and inducing ferroptosis of liver cancer cells, and the ferroptosis of liver cancer cells is promoted by overexpressing GCDH in cells, and the colony formation ability of liver cancer cells is reduced.Further, the application provides application of the overexpression reagent of GCDH combined with a CA9 inhibitor in preparing products for inhibiting proliferation of liver cancer cells.

This utility model discloses a dual-mode ultrasonic therapy device, including a housing. A therapy device is fixedly installed on the bottom inner side of the housing. A first support plate is fixedly installed on one side of the therapy device. A pair of treatment heads are positioned above the first support plate. A set of ventilation plates are symmetrically installed on the outer side of the housing. Ventilation slots are formed on both sides of the housing. A semi-circular plate is fixedly installed in the middle of the outer front end of the housing, with a circular groove below the semi-circular plate. The installation of the ventilation slots and ventilation plates ensures both air permeability and dust prevention, improving the overall safety of the device. The installation of the semi-circular plate and circular groove ensures both effective closure and stability when the device is closed, preventing it from easily falling off and further enhancing the user experience.

The application discloses a preparation method and application of a hollow manganese dioxide nanocarrier coated with a human umbilical cord mesenchymal stem cell membrane and a transmembrane peptide TAT, and is characterized in that: hollow mesoporous manganese dioxide is synthesized through a selective etching technology, and a layer of human umbilical cord mesenchymal stem cell membrane is coated outside the manganese dioxide through a repeated extrusion method. Since the cell membrane has special tumor homing characteristics, and lacks major histocompatibility complex-II and only expresses major histocompatibility complex-I in a trace amount, the key scientific problems and difficulties such as low biological safety, strong immunogenicity and easy elimination by the body of artificially synthesized nanomaterials can be effectively solved. Finally, the cell membrane surface is modified with the transmembrane peptide TAT through a phospholipid insertion method, precise subcellular localization-nucleus targeting is realized, and tumor cells can be more effectively killed.

The invention is applicable to the technical field of surface water processing and treatment, and provides comprehensive surface water treatment equipment which comprises a recycling barrel and a treatment pond, the three filter screens are arranged in parallel to the inner position of the recycling barrel in an inclined mode, and cleaning boxes are arranged on the sides, close to the filter screens, with the higher inclined gradient; the electric push rods are arranged in the cleaning boxes; the bearing blocks and the cleaning brooms are arranged at the telescopic ends of the electric push rods, and slag discharging openings are communicated with the sides, close to the filter screens, with the lower inclined gradient; according to the invention, impurities and suspended matters can be effectively removed from surface water in a preliminary filtering stage, chemical reaction and physical precipitation processes are accelerated through precise agent addition and full mixing, harmful substances such as microorganisms, organic matters and heavy metal ions in water are further removed through subsequent multi-stage purification treatment, and in addition, the water quality is improved. The efficient gas treatment system effectively avoids secondary pollution caused by harmful gas and peculiar smell generated in the treatment process.

The utility model discloses a pig testis fluid collecting device which comprises a sterilization assembly, the sterilization assembly comprises a disinfection bin, the disinfection bin is fixed to the outer wall of the top of a workbench, a hinge is installed on one side of the disinfection bin, one end of the hinge is connected with a sealing door, the sealing door is matched with the disinfection bin, and a handle is arranged on one side of the sealing door. Multiple groups of ultraviolet lamps are sequentially arranged and mounted on the inner wall of the disinfection bin, a rotating motor is arranged on the inner wall of the bottom of the disinfection bin, a rotating shaft is connected to the top of the rotating motor, a rotating frame is mounted on the top of the rotating shaft, and a liquid extracting assembly used for extracting pig testis liquid is mounted on one side of the workbench and comprises a collecting bin, and a supporting frame is arranged on the outer wall of the collecting bin; the two sets of supporting frames are installed on the two sides of the collecting bin respectively, the bottoms of the supporting frames are fixed to the outer wall of the top of the workbench, an opening is formed in the bottom of the collecting bin, a supporting plate is detachably arranged on the inner wall of the collecting bin, multiple sets of liquid outlets are evenly formed in the supporting plate, and a fixing frame is arranged on the outer wall of the top of the collecting bin.

The utility model discloses a campus direct drinking machine with an efficient sterilization function, and relates to the field of direct drinking machines, the campus direct drinking machine with the efficient sterilization function comprises a shell, a filtering system, a heat exchanger, a hot tank and a range extending water tank are installed in the shell, and the liquid outlet end of the filtering system is connected with a cold fluid inlet of the heat exchanger; according to the campus direct drinking machine with the efficient sterilization function, the range-extending water tank is large in water storage space, multiple external water outlets are connected with multiple faucets, water can be stably supplied when teachers and students use water in a centralized mode in a campus, the problem that water is insufficient when multiple faucets of a traditional direct drinking machine are started at the same time is solved, and the water use requirement of a crowded place is met. Meanwhile, a closed-loop sterilization system is formed through a filtering system, a hot tank, an overflowing type uv sterilization lamp, a correlation uv lamp in a range extending water tank and silver ions at a water nozzle, microorganisms in water are efficiently killed, the safety of drinking water is guaranteed, and the health of teachers and students is protected.

This invention provides a road base material based on sludge and construction waste, its preparation method, and its application. The road base material includes a base component and an admixture component. The base component includes: 45-55% recycled coarse aggregate, 20-35% recycled fine aggregate, 15-25% sludge, 4-6% cement, and 1-4% water. Both the recycled coarse and fine aggregates are derived from construction waste. The admixture component includes quicklime, sodium hydroxide, and zinc ricinoleate. The mass percentage of quicklime to sludge is 4-8%, the mass percentage of sodium hydroxide to sludge is 0.1-0.2%, and the mass percentage of zinc ricinoleate to sludge is 0.2-0.5%. This invention promotes the high-value utilization of urban solid waste such as sludge and construction waste, and yields a higher-performance road base material based on sludge and construction waste.

The invention belongs to the technical field of soil turning equipment, and particularly relates to soil turning operation equipment suitable for mountains and hills, which comprises a main body carrying frame, a linkage soil turning mechanism and an all-terrain moving system. In order to improve the soil turning efficiency of the hilly environment and reduce the inclination of the equipment, an all-terrain moving system is arranged, a driving motor drives an all-terrain wheel set to rotate, the soil turning equipment can move in an inclined field, meanwhile, the soil turning equipment can stably stop in the field, and a linkage soil turning mechanism can conveniently turn soil on the field; the driving motor is used for pushing the coulter set to turn soil, the coulter set is driven to rotate through the rotating spring after the coulter set is inserted into the land, deep soil is turned out, the soil is looser, circulation of air and water in the soil is facilitated, and growth and development of plant roots are promoted.

The invention relates to the technical field of immunity, in particular to a nano antibody specifically combined with CD276 and application of the nano antibody. The preparation method comprises the following steps: immunizing alpaca by adopting human CD276 antigen protein to obtain peripheral blood PBMC (peripheral blood mononuclear cell), then calling a nano antibody gene, establishing a phage library, finally obtaining an antibody sequence with relatively high antigen affinity respectively through a single B cell antibody screening technology and a phage library screening technology, and then applying the found antibody sequence to CAR-T to obtain a CAR-T antibody sequence with relatively high antigen affinity. Animal in-vivo and in-vitro drug effects show that the obtained antibody sequence is suitable for various solid tumor indications and has a remarkable anti-tumor effect on lung cancer, colorectal cancer and pancreatic cancer. The antibody sequence can be applied to development of antibody drugs, cell therapy drugs, ADC drugs and the like.

The invention provides an air conditioner which comprises a machine body, an air inlet pipe and an air outlet pipe. The sterilization module is arranged at the air outlet end of the air outlet channel; the air sweeping assembly is arranged in the air outlet channel and located on the side of the sterilization module, the air sweeping assembly comprises an air sweeping part, and at least part of the air sweeping part is arranged in the length direction of the air outlet channel in a swinging mode so as to guide airflow in the air outlet channel; the air guide assembly is movably arranged on the machine body so that the air outlet channel can be opened or closed, the air guide assembly comprises an air guide part, the air guide part is rotatably arranged around a preset axis, and airflow in the air outlet channel sequentially flows through the air sweeping part, the sterilization module and the air guide part and then is blown out. The problem that an air conditioner in the prior art is poor in air purification effect is solved.

The invention relates to the field of hygienic products, provides a high-softness skin-friendly sanitary napkin and a preparation method thereof, and solves the problems that an existing sanitary napkin is poor in antibacterial component attachment effect, cannot specifically inhibit vaginal harmful bacteria and promote the dominant position of vaginal beneficial bacteria in bacterial communities, does not have the function of releasing antibacterial components under specific conditions, and cannot be used for preparing the sanitary napkin. The problem that long-time contact between antibacterial components and vaginal skin cannot be reduced while efficient bacteriostasis is achieved, and the cytotoxicity is high is solved; the sanitary towel comprises a surface layer, a flow guide layer, a core body and a leakage-proof bottom film which are sequentially arranged from top to bottom, the surface layer is a modified pure cotton non-woven fabric, and the modified pure cotton non-woven fabric is obtained by dipping a pure cotton non-woven fabric in an antibacterial ingredient microcapsule mixed solution, rolling and then drying.

This invention provides a method for controlling Spartina alterniflora and promoting natural mangrove restoration based on rolling mulching and in-situ mud slurry, belonging to the field of ecological control technology. The method involves mechanically rolling Spartina alterniflora to flatten most of it and press it into the tidal flat soil. Then, a biodegradable mulch film is laid on top, and mud slurry is extracted and applied to form a mud slurry cover layer. A mangrove seed interception and planting device is then installed on the mud slurry cover layer to prevent mangrove seeds from growing naturally, thereby reducing the cost of Spartina alterniflora control and improving the efficiency of Spartina alterniflora control.