36 results about "Alginate microspheres" patented technology

The hydroxyethyl cellulose of dual template method modifies alginate microballoon as well as its Process for preparing. One is modified microballoon of emulsion template method, mixing hydroxyethyl cellulose solution and sodium alginate aqueous solution, adding liquid paraffin and emulsifier, and then dispersing it in organic oil phase, crosslinking to ball by calcium chloride aqueous solution, further crosslinking in aldehydes crosslinking agent, finally, getting the product after removing liquid paraffin. Another one is modified microballoon of macromolecule template method, dissolving sodium alginate in bovine serum albumin aqueous solution, mixing with hydroxyethyl cellulose and dispersing in organic oil phase, crosslinking to ball by calcium chloride aqueous solution, further crosslinking in aldehydes crosslinking agent, finally getting the product after eluting template molecule by buffer. The getted modified microballoons of the mentioned two methods are simple in technology, getting macroporose microballoon of uniform aperture and the microballoon hasing macromolecule template print effect, and effectively improving the mechanical strength of calcium alginate microballoon and instability in ionic environment.

The invention belongs to the field of medical dressings, and particularly relates to a continuous antibacterial hydrocolloid dressing and a preparing method thereof. The dressing is composed of a backlining layer, a functional layer dressing core and an isolation layer in sequence from bottom to top. The functional layer dressing core is prepared from, by weight, 15-20 parts of styrene-isoprene-styrene segmented copolymer (SIS), 15-20 parts of viscosity increasing resin, 10-15 parts of plasticizer, 10-15 parts of antioxidant and 30-50 parts of silver-loaded alginate microspheres. The continuous antibacterial hydrocolloid dressing has strong liquid absorption and humidity maintaining performance and has excellent continuous antibacterial performance, nanosilver contained in the hydrophilicsilver-loaded alginate microspheres in hydrocolloid is slowly released out of the silver-loaded alginate microspheres during liquid absorption swelling of alginate after the silver-loaded alginate microspheres make contact with blood or percolate, and the continuous antibacterial aim is achieved.

The invention relates to a preparation method of a magnetic ferric alginate mesoporous carbon microsphere capable of adsorbing heavy metal elements. The method comprises the steps that a sodium alginate saturated solution and urea are used for preparing an SAC precursor solution, a ferric alginate microsphere is synthesized through an ionic crosslinking method, and by means of vacuum freezing andhigh-temperature cracking methods, the magnetic ferric alginate mesoporous carbon microsphere (MAMC) with the surface to which nano-iron oxide is attached is obtained. Accordingly, preparation is easy, practicability is high, heat stability is good, and the adsorbing effect of the material on a water body As(III) and As(V) is good; the microsphere (MAMC) has superparamagnetism, separation of solute and solvent under external magnetic field interference can be achieved, therefore, heavy metal ions and materials can be stripped out of the water body after the material is adsorbed and saturated,and heavy metal secondary pollution is greatly avoided. In addition, the MAMC material is high in regeneration capacity and can be recycled multiple times, by conducing desorption and regeneration forfour times, the adsorption rate of the MAMC on As(III) is kept at 90%, and the cyclic utilization rate of the adsorbing material is further increased.

The present invention relates to a galactosyl grafted-modified alginate hydrogel microsphere carrier preparation method. According to the present invention, the occupation on the hydroxyl site of alginic acid does not affect the gelation performance of the alginic acid, such that the embedding type hydrogel microsphere carrier with characteristics of good sphericity and good stability can be prepared from the galactosyl alginic acid being subjected to the grafting reaction, and can further be subjected to the film forming reaction with polycations to form the galactosyl alginate/polycation microcapsule.

The invention relates to a rare earth metal ion supported alginate microsphere catalytic material and a method for preparing the same. The rare earth metal ion supported alginate microsphere catalytic material comprises water-soluble rare earth metal ion supported alginate hybrid materials, water-soluble high-polymer materials, Ca2+ cross-linking agents and water. The water-soluble rare earth metal ion supported alginate hybrid materials comprise alginate, stabilizer molecules and rare earth metal ions. The method includes stably and effectively connecting the rare earth metal ions in the hybrid materials onto molecular chains of the alginate in ionic bond and coordination bond forms; dissolving the water-soluble rare earth metal ion supported alginate hybrid materials and the water-soluble high-polymer materials in the water to obtain spinning solution and carrying out electrostatic spraying to obtain the rare earth metal ion supported alginate microsphere catalytic material. The rare earth metal ion supported alginate microsphere catalytic material and the method have the advantages that the method for preparing the catalytic material is free of pollution and easy to implement, and products rarely contain impurities; the alginate microsphere catalytic material prepared by the aid of the method is high in catalytic efficiency in the aspects of waste gas catalytic treatment, automobile exhaust catalytic decomposition and the like.

The preparation technique of protein medicine microsphere carrier with small grain size includes the following processes: under the condition of a certain pressure applying electric field and pulse frequency between pinhole and gel bath, making the mixed soliquoid of sodium alginate and hemoglobin pass through pinhole and drop into the gel bath containing divalent cation, and solidifying so as toobtain the alginate microphere for carrying protein. The main component of raw material liquor includes sodium alginate, Hb, non-ionic surfactant, and the main component of gel bath includes CaCl2 orBaCl2, polyvinyl alcohol, propanol and non-ionic surfactant.

The invention discloses a hyperbranched polyamide modified sodium alginate microsphere for heavy metal ion adsorption and a preparation method thereof. The preparation method comprises the following steps: (1) adding a sodium alginate solution to a CaCl2 solution dropwise, stirring while adding and conducting crosslinking reaction; filtering and cleaning after the reaction is finished to obtain asodium alginate microsphere; (2) adding the sodium alginate microsphere to a glutaraldehyde solution, then adding hydrochloric acid to carry out aldehyde reaction and filtering and cleaning to obtainthe sodium alginate microsphere containing aldehyde groups on the surface; (3) adding the sodium alginate microsphere containing the aldehyde groups on the surface into a hyperbranched polyamide solution and filtering, cleaning and drying after the reaction to obtain the hyperbranched polyamide modified sodium alginate microsphere. According to the preparation method, a strategy of first balling of the sodium alginate and then grafting is adopted, so that the grafting groups can be completely exposed on the surface of the microsphere, and the utilization rate of the grafting groups is effectively increased.

The invention provides an alginate microsphere encapsulating Bi2S3 nanoparticles and a preparation method thereof. The preparation method comprises the following steps: using a liquid-drop-type microfluidic technology, using sodium alginate aqueous solution containing a soluble sulfocompound as a dispersion phase, using an oil phase containing a surfactant as a continuous phase, forming a liquid drop in a microfluidic chip, importing the liquid drop into the aqueous solution containing Bi3<+> along with the continuous phase, and placing until a reaction is completed. The preparation method isbased on the liquid-drop-type microfluidic technology, and a sulfur source is provided by the sulfocompound in the dispersion phase. While the continuous phase is encountered in a microchannel, the dispersion phase is cut to the uniform liquid drops, and the liquid drops are imported to reception liquid containing the Bi3<+>, the in-situ formed alginate microsphere encapsulating Bi2S3 nanoparticles is obtained by one step. The process is simple, a particle diameter of the microsphere is controllable, and the obtained microsphere can be used as an intervention material. The microsphere has thefunctions of thermal therapy, embolism, CT imaging and sensibilization chemotherapy.

The invention relates to a stem cell microsphere gel compound for subcutaneous injection and a preparation method and application of the stem cell microsphere gel compound. The preparation method comprises the following specific steps: 1, separating umbilical cord mesenchymal stem cells; 2, preparing stem cell-alginate microspheres; 3, preparing hydrogel; 4, mixing the stem cell-alginate microspheres with the hydrogel, wherein the dispersion concentration of the stem cells in the hydrogen is 105-106 per mL; and 5, subcutaneously injecting the stem cell microsphere gel compound to a wound in atissue to repair tissue injury. A high polymer material such as hyaluronic acid and stem cells are embedded and combined through microspheres, the microspheres are dispersed into gel to form a biological scaffold material with a function of fixing cell factors released from stem cells in an oriented manner, targeted repair and therapy effects of stem cells can be improved remarkably, a physical barrier is formed by gel so that stem cell tumor formation risks are avoided, and by the structures of the microspheres, the cell factors released from the stem cells have the characteristic of controllability in slow releasing, and thus, the stem cell microsphere gel compound conforms to development tendency of safe drug administration and accurate drug administration, and has high clinical application value.

The invention belongs to the field of medical instruments, particularly relates to the field of medical biopolymer materials, and provides a marine plant extract induced tissue repair hydrogel wound dressing and a preparation method thereof.The marine plant extract induced tissue repair hydrogel wound dressing is obtained by mixing and crosslinking polyvinyl alcohol, carbomer, undecylamide betaine, medical glycerol and growth factor-loaded alginate microspheres; wherein the growth factor loaded alginate microspheres are prepared by a spray drying method. The marine plant extract induced tissue repair hydrogel wound dressing disclosed by the invention not only has relatively strong imbibition and moisturizing performance and excellent film-forming performance, but also has excellent antibacterial performance, wound dirt removal performance and excellent continuous healing promotion performance; the hydrophilic growth factor-loaded alginate microspheres in the hydrogel wound dressing are swelled along with imbibition of alginate after being in contact with blood or exudate, and the growth factors contained in the alginate microspheres are slowly released, so that the aim of continuously promoting healing is fulfilled.

The invention discloses a preparation method of composite silver nano-hydroxyapatite / alginate microspheres. The preparation method of the composite silver nano-hydroxyapatite / alginate microspherescomprises the following steps: (1) dissolving hydroxyapatite powder with an aqueous solution of sodium alginate, carrying out high-speed agitating and then centrifuging, and carrying out washing andprecipitating; and (2) adding a silver nitrate solution into the precipitate, carrying out high-speed agitating and then centrifuging, collecting precipitate, and washing the precipitate so as to obtain the composite silver nano-hydroxyapatite / alginate microspheres. The composite silver nano-hydroxyapatite / alginate microspheres prepared by the preparation method are free of toxic effects on living organisms, and are good in cell compatibility and biodegradability. Moreover, the raw materials are convenient and easy to obtain; the preparation method is simple, convenient and high in operability. Thus, promoted application is facilitated.

The invention relates to a method for continuously producing sodium alginate microspheres capable of efficiently removing heavy metals. The method comprises the following steps of: (1) firstly, addingan iron-manganese-sulfur micron-sized porous material with high specific surface area and high activity into a sodium alginate water solution, and performing sufficient and uniform stirring to obtaina mixed solution A; (2) continuously adding the mixed solution A prepared in the step (1) into a calcium chloride aqueous solution in a spraying manner, and performing stirring to react for 20-30 minutes to prepare iron-manganese-sulfur modified sodium alginate microspheres; and (3) filtering the iron-manganese-sulfur modified sodium alginate microspheres prepared in the step (2), and performingwashing with deionized water for at least three times to obtain the sodium alginate microspheres capable of efficiently removing heavy metals. The sodium alginate microspheres prepared by the method are controllable in morphology, uniform in particle size, high in particle strength and good in heavy metal adsorption effect. And the process flow of the sodium alginate microspheres prepared by the method is simple and controllable, the yield of the sodium alginate microspheres is high, large-scale mass production of thesodium alginate microspheres can be realized, and the sodium alginate microspheres has a bright market prospect.

The present invention discloses an efficient culture medium capable of effectively increasing a protein content of pleurotus ostreatus. The efficient culture medium comprises the following components in parts by weight: 2-3 parts of an alginate microsphere; lotus-type porous apple pomace ultrafine powder, bean cakes; wood chips; potato starches; hydroxylpropyl chitosan; a bioactive ferment lysate, and a growth promotion modulator. According to the invention, bean cakes and rapeseed cakes are used and fermented to prepare the pleurotus ostreatus culture medium so that such nutritive substances as abundant nitrogen and carbon sources are provided for the pleurotus ostreatus, thereby facilitating formation of the pleurotus ostreatus protein. Meanwhile, a nutrient-fortified growth regulation composite agent is added so as to facilitate absorption and utilization of nutritive substances by the pleurotus ostreatus, and effectively shorten the cultivation period of the pleurotus ostreatus, and increase the protein content of the pleurotus ostreatus . During preparation of the culture medium, porous lotus-shaped apple pomace ultrafine powder is used to adsorb loaded yeast, so that good living space is provided for the yeast, active time of the yeast is prolonged, substrate decomposition is promoted, balanced nutrients are provided for the pleurotus ostreatus, and a foundation for efficient cultivation of the pleurotus ostreatus is provided.