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39 results about "Alginate microspheres" patented technology
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Method for preparing alginate microsphere/high polymer composite nanometer fiber by electrostatic spinning
InactiveCN101555637AConvenient sourceEasy to operateWet spinning methodsMonocomponent polyesters artificial filamentFiberPolymer science
The invention relates to a method for preparing an alginate microsphere / high polymer composite nanometer fiber by electrostatic spinning. The method comprises the following steps of: dissolving alginate or alginate blend in distilled water or super purified water to obtain uniform alginate aquagel and water phase solution A; evenly mixing a surface activate agent and an organic solvent to obtain oil phase solution B; mixing the water phase solution A and the oil phase solution B according to a volume ratio of 1:10-15 with the addition of 0.1 to 0.5ml of calcium chloride solution, and shaking and evenly mixing the mixture to obtain mixed solution; adding a high polymer spinning material into the mixed solution for electrostatic spinning to obtain the alginate microsphere / high polymer composite nanometer fiber. The preparation method has simple operation and excellent economic benefit, is friendly to environment and is applicable to large-scale production; and the method combines the microsphere into the nanometer fiber, so that the prepared fiber performs excellence in both mechanical performance and slow release property compared with common electrospun fibers and has wider application prospect.
Owner:DONGHUA UNIV
Double-template method hydroxyethyl cellulose modified alginate microsphere and its preparation method
InactiveCN1807464ACheap and easy to getGood compatibilityBiological testingBovine serum albuminOil phase
The hydroxyethyl cellulose of dual template method modifies alginate microballoon as well as its Process for preparing. One is modified microballoon of emulsion template method, mixing hydroxyethyl cellulose solution and sodium alginate aqueous solution, adding liquid paraffin and emulsifier, and then dispersing it in organic oil phase, crosslinking to ball by calcium chloride aqueous solution, further crosslinking in aldehydes crosslinking agent, finally, getting the product after removing liquid paraffin. Another one is modified microballoon of macromolecule template method, dissolving sodium alginate in bovine serum albumin aqueous solution, mixing with hydroxyethyl cellulose and dispersing in organic oil phase, crosslinking to ball by calcium chloride aqueous solution, further crosslinking in aldehydes crosslinking agent, finally getting the product after eluting template molecule by buffer. The getted modified microballoons of the mentioned two methods are simple in technology, getting macroporose microballoon of uniform aperture and the microballoon hasing macromolecule template print effect, and effectively improving the mechanical strength of calcium alginate microballoon and instability in ionic environment.
Owner:TIANJIN UNIV
Continuous antibacterial hydrocolloid dressing and preparing method thereof
InactiveCN107998438AStrong liquid absorption and moisturizing performanceExcellent continuous antibacterial performancePharmaceutical delivery mechanismAbsorbent padsAntioxidantPlasticizer
The invention belongs to the field of medical dressings, and particularly relates to a continuous antibacterial hydrocolloid dressing and a preparing method thereof. The dressing is composed of a backlining layer, a functional layer dressing core and an isolation layer in sequence from bottom to top. The functional layer dressing core is prepared from, by weight, 15-20 parts of styrene-isoprene-styrene segmented copolymer (SIS), 15-20 parts of viscosity increasing resin, 10-15 parts of plasticizer, 10-15 parts of antioxidant and 30-50 parts of silver-loaded alginate microspheres. The continuous antibacterial hydrocolloid dressing has strong liquid absorption and humidity maintaining performance and has excellent continuous antibacterial performance, nanosilver contained in the hydrophilicsilver-loaded alginate microspheres in hydrocolloid is slowly released out of the silver-loaded alginate microspheres during liquid absorption swelling of alginate after the silver-loaded alginate microspheres make contact with blood or percolate, and the continuous antibacterial aim is achieved.
Owner:GUANGDONG TAIBAO MEDICAL SCI TECH
Preparation method of magnetic ferric alginate mesoporous carbon microsphere capable of adsorbing heavy metal elements
InactiveCN108554385AImprove adsorption capacityEasy to makeOther chemical processesWater contaminantsDesorptionSuperparamagnetism
The invention relates to a preparation method of a magnetic ferric alginate mesoporous carbon microsphere capable of adsorbing heavy metal elements. The method comprises the steps that a sodium alginate saturated solution and urea are used for preparing an SAC precursor solution, a ferric alginate microsphere is synthesized through an ionic crosslinking method, and by means of vacuum freezing andhigh-temperature cracking methods, the magnetic ferric alginate mesoporous carbon microsphere (MAMC) with the surface to which nano-iron oxide is attached is obtained. Accordingly, preparation is easy, practicability is high, heat stability is good, and the adsorbing effect of the material on a water body As(III) and As(V) is good; the microsphere (MAMC) has superparamagnetism, separation of solute and solvent under external magnetic field interference can be achieved, therefore, heavy metal ions and materials can be stripped out of the water body after the material is adsorbed and saturated,and heavy metal secondary pollution is greatly avoided. In addition, the MAMC material is high in regeneration capacity and can be recycled multiple times, by conducing desorption and regeneration forfour times, the adsorption rate of the MAMC on As(III) is kept at 90%, and the cyclic utilization rate of the adsorbing material is further increased.
Owner:HUNAN AGRICULTURAL UNIV +2
Galactosyl grafted-modified alginate microspheres and applications thereof
InactiveCN106399291AAffect gelationEffect of mechanical strengthOn/in organic carrierGraft reactionHydrogel microspheres
The present invention relates to a galactosyl grafted-modified alginate hydrogel microsphere carrier preparation method. According to the present invention, the occupation on the hydroxyl site of alginic acid does not affect the gelation performance of the alginic acid, such that the embedding type hydrogel microsphere carrier with characteristics of good sphericity and good stability can be prepared from the galactosyl alginic acid being subjected to the grafting reaction, and can further be subjected to the film forming reaction with polycations to form the galactosyl alginate / polycation microcapsule.
Owner:DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
Rare earth metal ion supported alginate microsphere catalytic material and method for preparing same
ActiveCN105879909ASimple processMild conditionsOrganic-compounds/hydrides/coordination-complexes catalystsCatalyst activation/preparationRare earthCatalytic decomposition
The invention relates to a rare earth metal ion supported alginate microsphere catalytic material and a method for preparing the same. The rare earth metal ion supported alginate microsphere catalytic material comprises water-soluble rare earth metal ion supported alginate hybrid materials, water-soluble high-polymer materials, Ca2+ cross-linking agents and water. The water-soluble rare earth metal ion supported alginate hybrid materials comprise alginate, stabilizer molecules and rare earth metal ions. The method includes stably and effectively connecting the rare earth metal ions in the hybrid materials onto molecular chains of the alginate in ionic bond and coordination bond forms; dissolving the water-soluble rare earth metal ion supported alginate hybrid materials and the water-soluble high-polymer materials in the water to obtain spinning solution and carrying out electrostatic spraying to obtain the rare earth metal ion supported alginate microsphere catalytic material. The rare earth metal ion supported alginate microsphere catalytic material and the method have the advantages that the method for preparing the catalytic material is free of pollution and easy to implement, and products rarely contain impurities; the alginate microsphere catalytic material prepared by the aid of the method is high in catalytic efficiency in the aspects of waste gas catalytic treatment, automobile exhaust catalytic decomposition and the like.
Owner:DONGHUA UNIV
Preparation technique of protein medicine microsphere carrier with small grain size
InactiveCN1476897AFast absorbencyRapid transitPowder deliveryPeptide/protein ingredientsPolyvinyl alcoholNon ionic
The preparation technique of protein medicine microsphere carrier with small grain size includes the following processes: under the condition of a certain pressure applying electric field and pulse frequency between pinhole and gel bath, making the mixed soliquoid of sodium alginate and hemoglobin pass through pinhole and drop into the gel bath containing divalent cation, and solidifying so as toobtain the alginate microphere for carrying protein. The main component of raw material liquor includes sodium alginate, Hb, non-ionic surfactant, and the main component of gel bath includes CaCl2 orBaCl2, polyvinyl alcohol, propanol and non-ionic surfactant.
Owner:DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
Hyperbranched polyamide modified sodium alginate microsphere for heavy metal ion adsorption and preparation method thereof
InactiveCN109261138AWide variety of sourcesImprove solubilityOther chemical processesWater contaminantsPolyamideSodium Alginate Microspheres
The invention discloses a hyperbranched polyamide modified sodium alginate microsphere for heavy metal ion adsorption and a preparation method thereof. The preparation method comprises the following steps: (1) adding a sodium alginate solution to a CaCl2 solution dropwise, stirring while adding and conducting crosslinking reaction; filtering and cleaning after the reaction is finished to obtain asodium alginate microsphere; (2) adding the sodium alginate microsphere to a glutaraldehyde solution, then adding hydrochloric acid to carry out aldehyde reaction and filtering and cleaning to obtainthe sodium alginate microsphere containing aldehyde groups on the surface; (3) adding the sodium alginate microsphere containing the aldehyde groups on the surface into a hyperbranched polyamide solution and filtering, cleaning and drying after the reaction to obtain the hyperbranched polyamide modified sodium alginate microsphere. According to the preparation method, a strategy of first balling of the sodium alginate and then grafting is adopted, so that the grafting groups can be completely exposed on the surface of the microsphere, and the utilization rate of the grafting groups is effectively increased.
Owner:ZHEJIANG SCI-TECH UNIV
Alginate microsphere encapsulating Bi2S3 nanoparticles and preparation method thereof
ActiveCN108578384AFunction increaseParticle size controllableSurgical adhesivesEnergy modified materialsMicrofluidic chipAlginate microspheres
The invention provides an alginate microsphere encapsulating Bi2S3 nanoparticles and a preparation method thereof. The preparation method comprises the following steps: using a liquid-drop-type microfluidic technology, using sodium alginate aqueous solution containing a soluble sulfocompound as a dispersion phase, using an oil phase containing a surfactant as a continuous phase, forming a liquid drop in a microfluidic chip, importing the liquid drop into the aqueous solution containing Bi3<+> along with the continuous phase, and placing until a reaction is completed. The preparation method isbased on the liquid-drop-type microfluidic technology, and a sulfur source is provided by the sulfocompound in the dispersion phase. While the continuous phase is encountered in a microchannel, the dispersion phase is cut to the uniform liquid drops, and the liquid drops are imported to reception liquid containing the Bi3<+>, the in-situ formed alginate microsphere encapsulating Bi2S3 nanoparticles is obtained by one step. The process is simple, a particle diameter of the microsphere is controllable, and the obtained microsphere can be used as an intervention material. The microsphere has thefunctions of thermal therapy, embolism, CT imaging and sensibilization chemotherapy.
Owner:HUAZHONG UNIV OF SCI & TECH
A novel j2-sodium alginate microsphere slow-release immunosuppressant for anti-graft immune rejection, preparation method and application
InactiveCN102258477AOrganic active ingredientsPharmaceutical product form changeSide effectWhole body
The invention discloses a novel anti-transplantation immunological rejection J2-sodium alginate microsphere slow release immunosuppressive agent, a preparation method and application. The slow release immunosuppressive agent comprises a natural matrix material and is convenient for microsphere implantation. In the preparation, sodium alginate is used as a drug carrier, a J2 immunocompetent component is crosslinked, and the immunosuppressive agent is wrapped or adsorbed in microspheres through a microsphere liquid droplet generation device under the action of calcium ions. The preparation has targeting property to specific tissues and organs; the local action time of the drug can be prolonged; the bioavailability of the drug is improved; the toxic or side effect of a whole body can be reduced; and the immunosuppressive agent can be applied to immunosuppression of transplantation of heart, liver, kidney, lung, skin and cornea.
Owner:BEIJING HONGYIYAO SCI & TECH DEV
Preparing method of modified gingko testa-alginate microsphere adsorbent
ActiveCN107321334AReduce pollutionGood repeatabilityOther chemical processesWater contaminantsPollutionPolyamine
The invention discloses a preparing method of a modified gingko testa-alginate microsphere adsorbent. The method comprises the steps that firstly thoroughly washed gingko testa is smashed, then the smashed gingko testa is added into an alkaline solution of diamine or polyamine, centrifugation is conducted after a reaction is conducted for a certain time, centrifugate and a phenol compound are reacted for a certain time and are then concentrated, then a certain amount of polymers is added, and the polymers and an alginate solution are mixed together, under stirring, a calcium chloride solution is injected, and the modified gingko testa-alginate microsphere adsorbent is prepared. The preparing method is simple in process, convenient to operate, controllable in technology, mild in condition, good in repeatability, low in cost and easy to apply and popularize, the prepared modified gingko testa-alginate microsphere adsorbent has good performance of adsorbing heavy metal ions and organic pollutant, further has certain innovative significance in reducing pollution and cleaning the environment, and has a wide application prospect.
Owner:QILU UNIV OF TECH
Stem cell microsphere gel compound for subcutaneous injection and application of stem cell microsphere gel compound
InactiveCN109125806AGood biocompatibilityPromote degradationPharmaceutical delivery mechanismProsthesisRepair tissueTherapeutic effect
The invention relates to a stem cell microsphere gel compound for subcutaneous injection and a preparation method and application of the stem cell microsphere gel compound. The preparation method comprises the following specific steps: 1, separating umbilical cord mesenchymal stem cells; 2, preparing stem cell-alginate microspheres; 3, preparing hydrogel; 4, mixing the stem cell-alginate microspheres with the hydrogel, wherein the dispersion concentration of the stem cells in the hydrogen is 105-106 per mL; and 5, subcutaneously injecting the stem cell microsphere gel compound to a wound in atissue to repair tissue injury. A high polymer material such as hyaluronic acid and stem cells are embedded and combined through microspheres, the microspheres are dispersed into gel to form a biological scaffold material with a function of fixing cell factors released from stem cells in an oriented manner, targeted repair and therapy effects of stem cells can be improved remarkably, a physical barrier is formed by gel so that stem cell tumor formation risks are avoided, and by the structures of the microspheres, the cell factors released from the stem cells have the characteristic of controllability in slow releasing, and thus, the stem cell microsphere gel compound conforms to development tendency of safe drug administration and accurate drug administration, and has high clinical application value.
Owner:广东克瑞斯普生物科技有限公司
Marine plant extract induced tissue repair hydrogel wound dressing and preparation method thereof
PendingCN114392390AGood moisturizing effectStrong liquid absorption and moisturizing performanceBandagesTissue repairWound dressing
The invention belongs to the field of medical instruments, particularly relates to the field of medical biopolymer materials, and provides a marine plant extract induced tissue repair hydrogel wound dressing and a preparation method thereof.The marine plant extract induced tissue repair hydrogel wound dressing is obtained by mixing and crosslinking polyvinyl alcohol, carbomer, undecylamide betaine, medical glycerol and growth factor-loaded alginate microspheres; wherein the growth factor loaded alginate microspheres are prepared by a spray drying method. The marine plant extract induced tissue repair hydrogel wound dressing disclosed by the invention not only has relatively strong imbibition and moisturizing performance and excellent film-forming performance, but also has excellent antibacterial performance, wound dirt removal performance and excellent continuous healing promotion performance; the hydrophilic growth factor-loaded alginate microspheres in the hydrogel wound dressing are swelled along with imbibition of alginate after being in contact with blood or exudate, and the growth factors contained in the alginate microspheres are slowly released, so that the aim of continuously promoting healing is fulfilled.
Owner:GUANGDONG TAIBAO MEDICAL SCI TECH
Paclitaxel-carrying magnetic fluorescent alginate microsphere system and preparation method thereof
InactiveCN108888772AEasy to operateMild experimental conditionsOrganic active ingredientsPowder deliveryFluorescenceChemistry
The invention discloses a paclitaxel-carrying magnetic fluorescent alginate microsphere system and a preparation method thereof. The preparation method includes the steps of preparing magnetic Fe3O4 nano particles by means of a hydrothermal process, and subjecting the particles to amination modification by means of (3-aminopropyl)trimethoxysilane; subjecting the modified particles to carboxylationmodification with SA (sodium alginate) to obtain Fe3O4 / SA magnetic microspheres; enabling the magnetic particles and GQDS (graphene quantum dots) / PTX (paclitaxel) to combine by the aid of chemical bond reaction under the activating action of carbodiimide and N-hydroxysuccinimide so as to obtain magnetic fluorescent alginate drug-carrying microspheres Fe3O4@SA / (PTX-GQDS). The preparation method ofthe system herein is simple to perform and has mild reaction conditions, and the system has high drug-carrying rate and is expectedly widely applicable to the field of biomedicine.
Owner:JINLING INST OF TECH
Composite silver nano-hydroxyapatite/alginate microspheres and preparation method thereof
PendingCN109529047AGood cell compatibilityPromote degradationOrganic active ingredientsInorganic non-active ingredientsAlginate microspheresApatite
The invention discloses a preparation method of composite silver nano-hydroxyapatite / alginate microspheres. The preparation method of the composite silver nano-hydroxyapatite / alginate microspherescomprises the following steps: (1) dissolving hydroxyapatite powder with an aqueous solution of sodium alginate, carrying out high-speed agitating and then centrifuging, and carrying out washing andprecipitating; and (2) adding a silver nitrate solution into the precipitate, carrying out high-speed agitating and then centrifuging, collecting precipitate, and washing the precipitate so as to obtain the composite silver nano-hydroxyapatite / alginate microspheres. The composite silver nano-hydroxyapatite / alginate microspheres prepared by the preparation method are free of toxic effects on living organisms, and are good in cell compatibility and biodegradability. Moreover, the raw materials are convenient and easy to obtain; the preparation method is simple, convenient and high in operability. Thus, promoted application is facilitated.
Owner:XINYANG NORMAL UNIVERSITY
Adsorption material based on modified sodium alginate microspheres and preparation method and application of material
ActiveCN110170311AImprove adsorption capacityEasy to makeOther chemical processesWater contaminantsIonEthanol
The invention discloses an adsorption material based on modified sodium alginate microspheres and a preparation method and application of the material. Sodium alginate and polyvinyl alcohol are dissolved in deionized water and then added dropwise into a boric acid solution containing calcium chloride to forming a gel pellet; the gel pellet is washed and added into an aqueous solution of a silane coupling agent; a product obtained after a reaction is dispersed in toluene, and 1,3-propane sultone is added for a reaction; after the reaction is completed, an obtained product is sequentially washedwith toluene, ethanol and deionized water and then dried to obtain the adsorbent material of the modified alginate microspheres. The provided adsorbent material of the modified sodium alginate microspheres not only has a simple preparation process, a low cost and a stable structure but also has high adsorption performance and recycling performance for cesium, and can be widely applied to comprehensive development and utilization of salt lake brine and geothermal water resources.
Owner:TIANJIN UNIV OF SCI & TECH
Method for continuously producing sodium alginate microspheres capable of efficiently removing heavy metals
InactiveCN112246225AHigh particle strengthIncrease productionOther chemical processesManganeseChloride
The invention relates to a method for continuously producing sodium alginate microspheres capable of efficiently removing heavy metals. The method comprises the following steps of: (1) firstly, addingan iron-manganese-sulfur micron-sized porous material with high specific surface area and high activity into a sodium alginate water solution, and performing sufficient and uniform stirring to obtaina mixed solution A; (2) continuously adding the mixed solution A prepared in the step (1) into a calcium chloride aqueous solution in a spraying manner, and performing stirring to react for 20-30 minutes to prepare iron-manganese-sulfur modified sodium alginate microspheres; and (3) filtering the iron-manganese-sulfur modified sodium alginate microspheres prepared in the step (2), and performingwashing with deionized water for at least three times to obtain the sodium alginate microspheres capable of efficiently removing heavy metals. The sodium alginate microspheres prepared by the method are controllable in morphology, uniform in particle size, high in particle strength and good in heavy metal adsorption effect. And the process flow of the sodium alginate microspheres prepared by the method is simple and controllable, the yield of the sodium alginate microspheres is high, large-scale mass production of thesodium alginate microspheres can be realized, and the sodium alginate microspheres has a bright market prospect.
Owner:HUBEI FORBON TECH
CT-visible mucous-adherence-type bifunctional microcapsules, and preparation method and application thereof
ActiveCN110038137ATo achieve the purpose of CT visualizationImprove real-time performanceOrganic active ingredientsX-ray constrast preparationsReceptorSodium sulfate
The invention discloses CT-visible mucous-adherence-type bifunctional microcapsules as well as a preparation method and application thereof. The preparation method of the CT-visible mucous-adherence-type bifunctional microcapsules comprises the following steps: preparing catecholated chitosan modified with catechol by utilizing a chemical grafting method; preparing alginate microspheres containingbarium sulfate by utilizing low-concentration alginic acid and a sodium sulphate solution as spray fluid as well as a barium chloride solution as receptor fluid by adopting an one-step electrostaticspray method; performing multi-layer surface coating on the alginate microspheres by utilizing the catecholated chitosan so as to obtain a chitosan / alginate microcapsule complex; and then, mixing the chitosan / alginate microcapsule complex with a trisodium citrate solution so as to obtain microcapsules. The microcapsules prepared by the preparation method have excellent mucous adherence characteristics and CT angiography properties; moreover, the microcapsules are also applicable in oral drug preparations, oral nutrient preparations and oral probiotics.
Owner:天益健康科学研究院(镇江)有限公司
An encapsulation bi 2 the s 3 Nanoparticle alginate microspheres and preparation method thereof
ActiveCN108578384BFunction increaseParticle size controllableSurgical adhesivesEnergy modified materialsActive agentNanoparticle
The invention provides an alginate microsphere encapsulating Bi2S3 nanoparticles and a preparation method thereof. The preparation method comprises the following steps: using a liquid-drop-type microfluidic technology, using sodium alginate aqueous solution containing a soluble sulfocompound as a dispersion phase, using an oil phase containing a surfactant as a continuous phase, forming a liquid drop in a microfluidic chip, importing the liquid drop into the aqueous solution containing Bi3<+> along with the continuous phase, and placing until a reaction is completed. The preparation method isbased on the liquid-drop-type microfluidic technology, and a sulfur source is provided by the sulfocompound in the dispersion phase. While the continuous phase is encountered in a microchannel, the dispersion phase is cut to the uniform liquid drops, and the liquid drops are imported to reception liquid containing the Bi3<+>, the in-situ formed alginate microsphere encapsulating Bi2S3 nanoparticles is obtained by one step. The process is simple, a particle diameter of the microsphere is controllable, and the obtained microsphere can be used as an intervention material. The microsphere has thefunctions of thermal therapy, embolism, CT imaging and sensibilization chemotherapy.
Owner:HUAZHONG UNIV OF SCI & TECH
A kind of developing embolic material and preparation method thereof
ActiveCN106552284BParticle size controllableNarrow distributionSurgical adhesivesX-ray constrast preparationsInterventional therapyArterial embolism
The invention discloses a developing embolic material and a preparation method of the developing embolic material. Developable barium-alginate embolic microspheres encapsulating in-situ synthesis barium sulfate particles are prepared from one step by the adoption of an electrostatic spraying technology, integration of a developing agent and the embolic material is achieved, and the problems that when interventional therapy is clinically adopted, indirect developing exists and rechecking is difficult are solved. The mono-dispersion microspheres with the grain diameter being 100-1000 microns can be obtained by adjusting and controlling the electrostatic spraying parameter, so that the mono-dispersion microspheres with the grain diameter being 100-1000 microns are suitable for embolism of vessels of different calibers. The development agent, barium sulfate, and the barium-alginate microspheres are formed at the same time, and the barium sulfate particles are evenly distributed in the microspheres and firmly fixed. Extracorporeal simulation experiments prove that the developing microspheres are quite stable within the testing time of 50 days. A big-eared rabbit right kidney arterial embolism experiment proves that the developing microspheres have a good developing effect and an embolic effect. Because the electrostatic spraying technology has the characteristics of being simple, rapid and low in cost, the one-step preparation method has the production potential.
Owner:HUAZHONG UNIV OF SCI & TECH
A kind of preparation method of magnetic core-shell alginate microsphere adsorbent
ActiveCN104707575BCause secondary pollutionEasy disposalOther chemical processesAlkali metal oxides/hydroxidesSorbentHigh pressure
Owner:SOUTHWEAT UNIV OF SCI & TECH
A kind of strontium α-calcium sulfate hemihydrate/nano silver/ginsenoside-loaded sodium alginate microsphere bone substitute material and preparation method thereof
ActiveCN110694107BGood biocompatibilityPromote degradationPharmaceutical delivery mechanismTissue regenerationArtificial bonePharmacology
The invention discloses a bone substitute material, which comprises the following components in parts by weight: 1 part of ginsenoside sodium alginate microspheres and 90-110 parts of strontium-doped calcium sulfate hemihydrate loaded with silver nanoparticles; the ginsenoside alginate In the sodium microspheres, the mass ratio of ginsenoside to sodium alginate is: ginsenoside: sodium alginate = 1:4000-12000. The invention loads ginsenosides into the natural polymer alginic acid microspheres, which can promote the proliferation, migration and osteogenic differentiation of human bone marrow stromal cells. At the same time, sodium alginate microspheres are introduced into calcium sulfate hemihydrate containing strontium, which improves The strontium calcium sulfate hemihydrate material has the problems of high brittleness and sudden release. The prepared bone substitute material is a composite artificial bone material with certain mechanical properties and drug sustained release; nano-silver is added to the bone repair material, which can reduce the Risk of inflammation due to bone infection from surgery or trauma.
Owner:THE EIGHTH AFFILIATED HOSPITAL SUN YAT SEN UNIV
Alginic acid salt / nano lanthanum hydroxide composite microspheres, and preparation method and application thereof
ActiveCN120960168BUniform particle sizegood size controlInorganic active ingredientsAntinoxious agentsChemical industryPhysical chemistry
The present application relates to the technical field of medicine and chemical industry, in particular to a kind of alginate / nano lanthanum hydroxide composite microspheres and its preparation method and application.The composite microspheres use sodium alginate as organic matrix material, and nano lanthanum hydroxide as inorganic filling phase, which are prepared by electrospray technology, and can realize the uniform dispersion and wrapping of nano lanthanum hydroxide in alginate microspheres.The size of the composite microspheres can be adjusted as needed between 235.5 μm and 748.4 μm, and the mass ratio of alginate to nano lanthanum hydroxide can be adjusted as needed within 1: (0.5-1.5).The composite microspheres of the present application have a phosphorus binding capacity of 41.0 mg / g-90.0 mg / g in a gastric acid environment with pH=2, and excellent phosphorus binding ability, which can be used as an oral phosphorus binding agent for the treatment of hyperphosphatemia, providing a new technical solution for clinical intervention of hyperphosphatemia.
Owner:WUHAN UNIV OF TECH
A kind of asiaticoside-chitosan-sodium alginate microsphere, preparation method and application thereof
ActiveCN112315943BGood sustained release effectImprove uniformityPowder deliveryOrganic active ingredientsFreeze-dryingEthylic acid
The invention discloses asiaticoside-chitosan-sodium alginate microspheres, a preparation method and application thereof, and belongs to the technical field of biomedical materials. The microspheres are prepared by an emulsification cross-linking method and finally obtained by freeze-drying. The preparation method comprises the following steps: 1) preparing sodium alginate solution and asiaticoside-chitosan acetic acid solution respectively; 2) slowly and uniformly adding sodium alginate solution to the oil phase, stirring at high speed to form colostrum; 3) ) Slowly and evenly add the asiaticoside-chitosan acetic acid solution to the colostrum, stir, and fully emulsify; 4) Slowly and evenly add the glyceraldehyde solution to cross-link and solidify, centrifuge, and the precipitate is washed with petroleum ether successively. washing, washing with absolute ethanol, and vacuum freeze-drying to obtain light yellow powder of asiaticoside-sodium alginate-chitosan microspheres.
Owner:GUANGDONG OCEAN UNIVERSITY
Radiotherapeutic microspheres
Certain embodiments are directed to compositions comprising and method for producing alginate microspheres that contain liposomes encapsulating a variety of useful substances. Substances of note that can be encapsulated in liposomes and loaded into alginate microspheres include radiotherapeutics (e.g., rhenium-188), radiolabels (e.g., technetium-99m), chemotherapeutics (doxorubicin), magnetic particles (e.g., 10 m iron nanoparticles), and radio-opaque material (e.g., iodine contrast).
Owner:BOARD OF RGT THE UNIV OF TEXAS SYST
A device, method and application for preparing monodisperse calcium alginate microspheres
ActiveCN112044371BNo toxicityPermeableGel preparationMicroballoon preparationPetri dishCalcium alginate
The present invention relates to a device, method and application for preparing monodisperse calcium alginate microspheres, comprising coaxially arranged inner-phase glass tubes, middle-phase glass tubes and outer-phase glass tubes, and the inner-phase glass tube passes through the second dispensing The needle is inserted into the middle phase glass tube, the middle phase glass tube passes through the third dispensing needle and inserted into the outer phase glass tube, the outer phase glass tube extends into the collection culture dish, and the inner phase glass tube communicates with the inner cavity of the first dispensing needle , the middle phase glass tube communicates with the inner space of the second dispensing needle, the outer phase glass tube communicates with the inner space of the third dispensing needle, and the first dispensing needle, the second dispensing needle and the third dispensing needle are fixedly connected with the bottom plate , the device and method of the present invention can prepare calcium alginate microspheres with better sphericity.
Owner:SHANDONG UNIV
Adsorption material based on modified sodium alginate microspheres and its preparation method and application
ActiveCN110170311BImprove adsorption capacityEasy to makeOther chemical processesWater contaminantsPolyvinyl alcoholCoupling reagent
The invention discloses an adsorption material based on modified sodium alginate microspheres and its preparation method and application. Sodium alginate and polyvinyl alcohol are dissolved in deionized water, and then added dropwise to a boric acid solution of calcium chloride Form gel balls in the medium; wash the gel balls and add them to the aqueous solution of silane coupling agent to react; disperse the reacted products in toluene, add 1,3-propane sultone to react; after the reaction , followed by washing with toluene, ethanol and deionized water, and drying to obtain the adsorption material of modified sodium alginate microspheres. The adsorption material of the modified sodium alginate microspheres provided by the present invention not only has a simple preparation process and low cost, but also has a stable structure, has good adsorption performance and recycling performance for cesium, and can be widely used in the synthesis of salt lake brine and geothermal water resources develop and use.
Owner:TIANJIN UNIV OF SCI & TECH
Sustained-release drug-loaded microspheres as well as preparation method and application thereof
PendingCN121695109APeptide/protein ingredientsInorganic non-active ingredientsLymphocyteT lymphocyte
The invention discloses a sustained-release drug-loaded microsphere and a preparation method and application thereof, the sustained-release drug-loaded alginate microsphere prepared by a freeze spray drying method has good dispersibility and stability in an aqueous solution, and can effectively release loaded active components. After being injected into a tumor in situ, the hyaluronidase and the chemotactic factor can be released in a long-acting manner, the number and functions of the infiltrating T cells in the tumor are increased, the anti-tumor effect of the infiltrating T cells is effectively improved, and the T cell depletion is improved. Therefore, the time and the cost of lymphocyte in-vitro culture are shortened, and the curative effect of the tumor infiltration lymphocyte therapy is enhanced. After T lymphocytes are transfused back, sustained-release drug-loaded microspheres are injected in situ, so that the collection efficiency of the T cells at a tumor part and the activity of the T cells can be improved, the transfused T cells can play an anti-tumor role, and the curative effect is enhanced.
Owner:SUZHOU UNIV
A kind of preparation method of modified Ginkgo biloba exocarp-alginate microsphere adsorbent
ActiveCN107321334BReduce pollutionGood repeatabilityOther chemical processesWater contaminantsPolyaminePollution
The invention discloses a preparing method of a modified gingko testa-alginate microsphere adsorbent. The method comprises the steps that firstly thoroughly washed gingko testa is smashed, then the smashed gingko testa is added into an alkaline solution of diamine or polyamine, centrifugation is conducted after a reaction is conducted for a certain time, centrifugate and a phenol compound are reacted for a certain time and are then concentrated, then a certain amount of polymers is added, and the polymers and an alginate solution are mixed together, under stirring, a calcium chloride solution is injected, and the modified gingko testa-alginate microsphere adsorbent is prepared. The preparing method is simple in process, convenient to operate, controllable in technology, mild in condition, good in repeatability, low in cost and easy to apply and popularize, the prepared modified gingko testa-alginate microsphere adsorbent has good performance of adsorbing heavy metal ions and organic pollutant, further has certain innovative significance in reducing pollution and cleaning the environment, and has a wide application prospect.
Owner:QILU UNIV OF TECH
Antibacterial cleaning towel containing biological antiviral factors and preparation method thereof
PendingCN121915602ABiochemical treatment with enzymes/microorganismsGrip property fibresBiotechnologySpinning
The invention discloses an antibacterial cleaning towel containing biological antiviral factors and a preparation method of the antibacterial cleaning towel. The towel is prepared by compounding natural fibers such as bamboo fibers, aloe fibers and chitosan modified viscose fibers with functional components such as nano-silver loaded alginate microspheres, a biological antiviral factor compound liquid, far infrared ceramic powder and a biquaternary ammonium salt softening agent. The preparation method comprises the steps of fiber mixing, ring spinning, functional finishing liquid dipping, drying, heat setting and the like. Through the synergistic effect of various active components, the towel is endowed with efficient and lasting antibacterial and antiviral performance, and meanwhile, the towel has good biological safety and use comfort. Experiments show that the towel can still keep the antibacterial rate of 95% or above after being washed for multiple times, is obviously superior to a traditional antibacterial towel, is suitable for daily cleaning, medical care, public places and other scenes with high sanitation requirements, and has important practical value and popularization significance.
Owner:HEJING NANO NEW MATERIAL TECHNOLOGY (JIANGSU) CO LTD