106 results about "Bezoar" patented technology

The invention provides a traditional Chinese medicine composition and an application thereof in preparing a product for preventing, alleviating or treating acute hepatopancreatic necrosis of shrimp, belonging to the field of veterinary medicine. The active ingredients of the traditional Chinese medicine composition include isatis root, artificial bezoar, liquorice, borneol, pig gall powder and xuanming powder. The traditional Chinese medicine composition has a good therapeutic effect on preventing, alleviating or treating acute hepatopancreatic necrosis of shrimp, with a cure rate of more than 70%, has antibacterial and liver-protecting effects, can effectively improve the degree of liver damage, improve the survival rate of shrimp and reduce losses.

The invention discloses mixing and compounding equipment and a compounding process for producing calculus bovis factitius, and relates to the field of mixing equipment. The premixing cavity is formed in the mixing tank, meanwhile, a solution in the mixing tank can be pumped and conveyed into the premixing cavity through the liquid inlet assembly, when solid raw materials are added into the premixing cavity, the rotary driving assembly drives the shearing and mixing assembly to rotate in the premixing cavity, and the solid raw materials are sheared into fine particles; the solid raw materials and the solution are fully mixed and dissolved in the solution, then the premixed solution is conveyed into the mixing tank through the liquid distribution mechanism, and the solid raw materials are sheared and premixed, so that the solid raw materials can be prevented from being bonded into blocks after being added into the mixing tank, and the dissolving and mixing efficiency of the solid raw materials is improved; the dissolved solid raw materials are uniformly distributed in the mixing tank through the liquid distribution holes, so that the mixing efficiency of the solid raw materials and a solution in the mixing tank can be improved, and the mixing and compounding effect and the mixing and compounding efficiency of the mixing and resetting equipment are improved.

The invention belongs to the technical field of in-vitro cultivation of calculus bovis, and particularly relates to a method for in-vitro cultivation of calculus bovis. According to the invention, firstly, the escherichia coli is subjected to bile domestication and ray induced mutation, a high-activity oxgall-resistant bezoar production engineering bacterium E.coli-NH01 is obtained through screening, a method for in-vitro cultivation of bezoar by using the engineering bacterium E.coli-NH01 is provided, the prepared bezoar meets the pharmacopoeia standard, the production efficiency of in-vitro cultivation of bezoar is improved, and the production cost is reduced. And the production cost is reduced, the overall forming period is shortened, and the key that precious traditional Chinese medicinal materials are popular can be achieved.

The invention relates to the field of traditional Chinese medicine compositions, in particular to a composition for dispelling effects of alcohol and protecting liver and application. The composition for dispelling the effects of alcohol and protecting the liver comprises the following raw materials: 1-4 parts of calculus bovis factitius, 1-4 parts of artificial bear gall, 35-55 parts of a pseudo-ginseng extract, 40-60 parts of a herba artemisiae scopariae extract, 50-70 parts of a rhizoma smilacis glabrae extract, 30-50 parts of a polygonum cuspidatum extract, 30-50 parts of a radix paeoniae alba extract, 70-90 parts of a pueraria flower extract, 40-60 parts of a rhizoma polygonati extract and 40-60 parts of a dark malt extract. And 25-35 parts of a fructus amomi extract. The hangover-alleviating and liver-protecting composition has the advantages that the hangover-alleviating and liver-protecting effects are similar to that of a positive medicine Haiwang Jinvessel for relieving rat body mass reduction caused by an acute drunkenness model, the hangover-alleviating rate within 6 hours and the liver-protecting and anti-oxidation effects are similar to that of a positive medicine Haiwang Jinvessel, the body mass improvement effect, the hangover-alleviating rate and the anti-oxidation capability of a body are better, and the hangover-alleviating and liver-protecting composition has good development and application values.

The invention belongs to the technical field of cosmetic raw materials, and particularly discloses a method for preparing a cosmetic raw material with anti-inflammatory, soothing and repairing effects through a microbial fermentation method, and the method comprises the following steps: S1, preparing a fermentation culture medium; s2, preparing fermentation liquor: culturing saccharomyces cerevisiae and / or lactobacillus plantarum, and then inoculating the saccharomyces cerevisiae and / or lactobacillus plantarum into the fermentation culture medium obtained in the step S1 to obtain the fermentation liquor; s3, sieving the fermentation liquor obtained in the step S2 to obtain an upper-layer active raw material and a lower-layer substance; centrifuging the obtained lower-layer substance, and performing freeze drying treatment to obtain a lower-layer active raw material; and S4, mixing the upper-layer active raw material and the lower-layer active raw material obtained in the step S3, and then adding calculus bovis factitius. According to the invention, a specific strain is utilized to ferment a specific fermentation culture medium raw material, and the obtained cosmetic raw material active ingredients have very good anti-inflammatory, soothing and repairing effects; and the preparation process is simple and easy for large-scale production.

The invention belongs to the technical field of biochemical pharmacy, and particularly relates to a bezoar intermediate and a preparation method of bezoar. The preparation method comprises the following steps: mixing preparation raw materials and biochemical reaction liquid to obtain a mixed raw material solution; the preparation raw materials comprise bilirubin, organic active raw materials and vitamins, the biochemical reaction liquid is sterile purified water, and the bilirubin comprises bilirubin or biliverdin; and reacting the mixed raw material solution to obtain the bezoar intermediate. The content of combined bilirubin in the bezoar intermediate prepared by the preparation method provided by the invention is 75%-85%, the content of combined biliverdin is 73%-83%, and the yield is 83%-87%. According to the method, the poisoning and destroying effects of mycotoxin on the content, the yield, the biological activity and the oxidation resistance of the bezoar intermediate are effectively eliminated. The content, the yield, the oxidation resistance and the biological activity of the bezoar intermediate are greatly improved, the performance is stable, and the quality of bezoar is ensured.

The invention discloses an application of a traditional Chinese medicine composition in preparation of a medicine for preventing and treating atherosclerosis combined with hyperhomocysteinemia and / or hyperlipidemia. The traditional Chinese medicine composition comprises the following components: ginseng, lucid ganoderma, safflower, musk, calculus bovis, bear gall, pearl, venenum bufonis, radix aconiti carmichaeli and borneol. According to the traditional Chinese medicine composition disclosed by the invention, through reasonable compatibility of all the components, at least one of indexes such as aorta plaque area, vasomotor inner diameter difference, intima-media thickness, blood fat level, homocysteine content and the like in atherosclerosis combined with hyperhomocysteinemia and / or hyperlipidemia can be effectively improved; the symptoms of atherosclerosis combined with hyperhomocysteinemia and / or hyperlipidemia are relieved from multiple aspects, and the progress of the disease course is blocked. The traditional Chinese medicine composition is controllable in quality, convenient for standardized production, safe and reliable in prescription and free of toxic and side effects on human bodies.

The invention discloses an echinacea micromolecule peptide composition for promoting yield increase of natural calculus bovis. The echinacea micromolecule peptide composition comprises four sections of micromolecule peptides of peptide sequences A, B, C and D, the composition is extracted from echinacea through a specific process, and the proportion of each peptide sequence is 15-35%. When the sodium alginate microsphere carrier is prepared into a solution to be injected or loaded on the sodium alginate microsphere carrier to be implanted near the gallbladder of cattle, the formation rate of the natural calculus bovis can be remarkably improved to 60-65%, the average weight is greatly increased, and cholecystitis can be relieved. Compared with a traditional method, the technology is safe, efficient, wide in raw material source, low in cost and capable of specifically acting on bezoar to form a key target spot, and bezoar formation is promoted through cooperation of multiple links.

The invention provides a Mongolian medicine composition for treating hepatitis B and a preparation method of the Mongolian medicine composition. The composition is prepared from the following components in parts by weight: 75 to 85 parts of saffron, 75 to 85 parts of trogopterus dung, 65 to 75 parts of gardenia jasminoides, 45 to 55 parts of cortex phellodendri, 45 to 55 parts of dianthus chinensis, 55 to 65 parts of gypsum, 55 to 65 parts of scabiosa, 55 to 65 parts of calamine, 55 to 65 parts of caulis akebiae, 25 to 35 parts of rhizoma coptidis, 25 to 35 parts of fructus gardeniae, 25 to 35 parts of calomel, 25 to 35 parts of bunge corydalis herb, 45 to 55 parts of elecampane, 45 to 55 parts of rose and 55 to 65 parts of calculus bovis factitius. The Mongolian medicine composition for treating hepatitis B is prepared from multiple raw materials, meanwhile, the added coptis chinensis and rose flowers are treated through a specific extraction mode and a specific fermentation mode, and the prepared Mongolian medicine composition for treating hepatitis B has an excellent hepatitis B treatment effect.

The application relates to the technical field of biological pharmacy, and discloses a method for preparing high-bionic bovine bezoar by using a 3D printing technology and application. The preparation raw material of the high-bionic bovine bezoar comprises the following components: fermented bovine bile, saturated calcium hydroxide, hydroxypropyl methyl cellulose, bilirubin, cholic acid, deoxycholic acid and taurine; wherein the fermented bovine bile is obtained by fermenting bovine bile by using escherichia coli. The high-bionic bovine bezoar prepared by using the preparation raw material to perform 3D printing can be comparable to natural bovine bezoar in terms of components, effects and appearance, the main pharmaceutical components can be adjusted according to actual requirements, the production cost of the bovine bezoar can be greatly reduced, and the demand of people for the bovine bezoar can be met.

This invention provides the application of Jiawei Xihuang Pill (MXHP) in the preparation of drugs for the prevention and / or treatment of malignant tumors. This invention also provides the application of Jiawei Xihuang Pill in combination with chemotherapy drugs for the prevention and / or treatment of malignant tumors, particularly glioblastoma multiforme (GBM), wherein the active ingredients of Jiawei Xihuang Pill are prepared from bezoar, musk, vinegar-processed frankincense, vinegar-processed myrrh, and Panax notoginseng root extract in a weight ratio of 14-16:14-16:545-555:545-555:245-255. MXHP can synergistically inhibit the growth of glioblastoma in situ and induce tumor cell apoptosis, indicating that MXHP may be a potential therapeutic drug. Furthermore, compared to XHP, MXHP significantly prolongs the median survival of GBM, exhibiting an enhanced anti-GBM effect.

The application belongs to the field of traditional Chinese medicines, and particularly relates to a more low-irritation analgesic ancient prescription microemulsion gel and application thereof in anti-arthritis drugs. The application finds that after water-soluble and fat-soluble components of black plaster prepared from raw frankincense, myrrh, eaglewood, dragon's blood, Strychnos nux-vomica, Panax notoginseng, Oldenlandia diffusa, Venenum Bufonis, bovine bezoar, Stachys jamaicensis, Platycodon grandiflorum, Hirudo nipponia, Tinea, Solenopsis geminata, Scorpio, scorpio, red lead and sesame oil are extracted, a more low-irritation analgesic ancient prescription microemulsion gel is prepared; compared with the black plaster itself, the analgesic effect of the microemulsion gel is significantly improved, and the microemulsion gel has good anti-inflammatory effect and can be used for preparing anti-arthritis drugs; and the microemulsion gel has reduced toxicity and is more convenient to use.

The invention belongs to the technical field of detection and analysis, and provides an HPLC detection method for taurocholic acid in snake gall bulbus fritilariae liquid, which comprises the following steps: collecting chromatograms of a test sample and a reference substance through HPLC, and judging whether a co-outflow phenomenon exists or not; if the co-outflow phenomenon occurs, interference proportion analysis is carried out, and main interferents are identified; the judged main interferents are removed; carrying out retention analysis to obtain a taurocholic acid retention rate, judging whether the taurocholic acid retention rate accords with expectation or not based on the taurocholic acid retention rate, and if not, judging whether a trailing signal is triggered or not; if the trailing signal is triggered, performing cause analysis to determine the cause of triggering the trailing signal; when the optimal methanol proportion is obtained, a comprehensive detection signal is triggered; if the comprehensive detection signal is triggered, performing comprehensive adaptation analysis of the HPLC detection method to obtain an adaptation index, and evaluating the comprehensive performance of the HPLC detection method according to the adaptation index; and the accuracy of HPLC taurocholic acid detection is effectively improved.

The utility model discloses a compressible self-expansion type bezoar bed which comprises a flexible bezoar bed body, a cover body and elastic frameworks, the side wall of the bezoar bed body is provided with a plurality of wavy elastic frameworks in the length direction, and the elastic frameworks are arranged in a surrounding mode in the circumferential direction of the side wall of the bezoar bed body; the yellow bed body is of a hollow structure, compressible cover bodies are arranged at the two ends of the yellow bed body respectively, and flowing holes are formed in the middles of the cover bodies. Through the bezoar bed main body, the cover body and the elastic framework, the whole bezoar bed can be compressed longitudinally and transversely, and the size of a wound needing to be cut when the bezoar bed is implanted into a cattle body is effectively reduced. By means of the bezoar bed of the hollow structure and the flowing holes, the flow of bile in the bezoar bed is increased, bezoar particles in the bezoar bed can be intercepted through the cover body, bezoar is promoted to be enriched and nucleated, the quality of cultivated bezoar is effectively improved, and the bezoar bed has good practicability.

The invention provides a high-fidelity calculus bovis and a preparation method thereof, and belongs to the technical field of traditional Chinese medicines. According to the technical scheme provided by the invention, the high-fidelity calculus bovis is accurately prepared by taking the mean value of the contents of various components of the natural calculus bovis as a reference and accurately measuring the contents of various components in the raw materials, fully utilizing the original components of the ox bile or ox gall powder, not adding other non-calculus bovis components and combining the existence forms of the components. The problems that existing artificial calculus bovis is greatly different from natural calculus bovis in efficacy, and toxic and side effects are relatively high are solved. The shape, the forming process and the components of the product are highly similar to those of natural calculus bovis; the medicine effect of the calculus bovis is improved, and the production cost is reduced.

The invention relates to the technical field of traditional Chinese medicine, in particular to a Chinese and western medicine composition for treating wind-heat type common cold and a preparation method and application thereof. The traditional Chinese and western medicine composition comprises the following components in parts by weight: 4-8 parts of a traditional Chinese medicine extract A; 3-7 parts of a traditional Chinese medicine extract B; 5-10 parts of a traditional Chinese medicine extract C; 1-5 parts of a western medicine composition D; the traditional Chinese medicine extract A is prepared by performing CO2 supercritical extraction and volatile oil clathration on honeysuckle; the traditional Chinese medicine extract B is obtained by carrying out enzymolysis on honeysuckle and isatis root; the traditional Chinese medicine extract C is prepared from honeysuckle and radix isatidis through ultrasonic extraction; the western medicine composition D is prepared from raw material components including calculus bovis factitius, acetaminophen and amantadine hydrochloride. The Chinese and western medicine composition is simple in component, can enhance the anti-inflammatory, cough-relieving and phlegm-eliminating effects, and obviously improves various symptoms caused by cold.

The invention belongs to the technical field of biochemical pharmacy, and particularly relates to a compound bezoar composition, decoction piece type compound bezoar and a preparation method of the decoction piece type compound bezoar. The compound calculus bovis composition provided by the invention comprises 94-96% by mass of main agents and 8 kinds of calculus bovis intermediates, the mass content of the auxiliary agent is 4-6%, and the auxiliary agent is six commercially available finished product combined cholic acid. The bilirubin content of the bezoar intermediate used in the invention is increased by more than 30% and the yield is increased by more than 25% compared with the existing biochemical reaction process of oxgall. The DPPH free radical scavenging rate of the compound bezoar composition reaches 89.6% + / -2.1% and is increased by 25.7-36.9% compared with 58.3% + / -3.5% of a product prepared from ox bile, and through t inspection, p is smaller than 0.01 (n is equal to 5). Free cholic acid intervention is strictly prohibited, lithocholic acid addition is completely eradicated, and the composition has the advantages of being high in bilirubin content, high in oxidation resistance and high in biological activity and adapts to the physiological characteristics of the human body.

This invention discloses a single-herb bezoar preparation based on an ancient prescription; an enteric-coated bezoar soft capsule and its preparation method. The enteric-coated bezoar soft capsule consists of a bezoar dispersion and an enteric-coated soft capsule shell. A sand mill is used to prepare bezoar powder into micron-sized particles with a particle size ≤100μm. The micron-sized bezoar powder is fully dispersed in a dispersion medium, thereby improving the solubility of bezoar. The single-herb bezoar preparation can improve the problem of inconsistent bezoar content in compound bezoar preparations. The process of preparing the ≤100μm micron-sized bezoar dispersion uses non-metallic grinding equipment, avoiding the catalytic reaction of metal ions during the preparation of micron-sized powder. Low-temperature grinding is also used to avoid denaturation of the heat-sensitive active substances in bezoar, better preserving its biological activity. The enteric-coated formulation prevents the drug from being released in the stomach until it reaches the small intestine, avoiding the precipitation of bilirubin and other bile acids in the acidic environment of the stomach, which would otherwise lead to insoluble solids and poor solubility.

The utility model discloses an Angong bezoar pill ceramic box which comprises a box body and a box cover, an annular flange is fixed on the edge of the bottom of the box cover, the box cover is clamped at an opening of the box body through the annular flange, a piece of screen cloth covers the lower surface of the annular flange, and the outer periphery of the screen cloth is fixed on the peripheral side wall of the annular flange. A containing cavity is formed between the screen cloth and the bottom of the box cover, a limiting notch is further formed in the middle of the screen cloth, a soft cushion is placed in the box body, a groove is formed in the top of the soft cushion, when the box cover is clamped at the opening of the box body, the limiting notch and the groove are matched to fix an Angong bezoar pill, and part of the Angong bezoar pill extends into the containing cavity. According to the ceramic box for the Anggong bezoar pills, the Anggong bezoar pills cannot be in direct contact with the box body and the box cover, and the situation that some active ingredients or auxiliary materials contained in the Anggong bezoar pills are possibly subjected to chemical reaction in the long-term contact process with plastic, and consequently the ingredients of the Anggong bezoar pills are changed or the medicine effect is reduced is avoided.

The invention discloses an oxgall-tolerant in-vitro calculus bovis culture transformation strain and application thereof, and belongs to the technical field of calculus bovis culture. The strain is obtained by separating and purifying fresh ox bile, is identified to belong to escherichia coli, has excellent ox bile tolerance, has the characteristics of beta-glucuronidase, high bezoar conversion rate and high safety, and can be used in the production of in-vitro artificial cultivation of bezoar. The strain is a brand new strain for in-vitro calculus bovis transformation, not only enriches a strain resource library of calculus bovis transformation bacteria, but also provides a new thought for deep research of subsequent in-vitro calculus bovis culture.

The invention discloses a method for culturing calculus bovis by utilizing flora, which is characterized in that cattle gall bladders obtained by slaughtering are used as reaction containers, so that the animal welfare problem caused by living body surgery is completely avoided. A plurality of key steps of bilirubin generation, cholesterol conversion, matrix formation and the like are synergistically completed by adopting functional complementary synthetic flora, and the components of the generated product are closer to a complex system of natural calculus bovis. The breeding is carried out in a closed bioreactor with controllable parameters, uncontrollable factors such as individual cattle difference and feeding environment are eliminated, and the product quality is highly stable and uniform. Automatic monitoring and feedback control are achieved in the whole cultivation process, and technological parameters are accurate and adjustable. The used strains are all non-pathogenic or food-grade safe strains, and the whole process is sterile, free of exogenous pathogen pollution and antibiotic residue risks, and high in biological safety.

The invention discloses fermentation equipment, and a preparation production line and a production process of in-vitro cultured calculus bovis, and relates to the field of fermentation equipment. According to the invention, the fermentation tank is provided with the biological detection analyzer capable of detecting the number and the state of the strains in the fermentation tank, and the oxygen supply amount of the oxygen inlet pipe to the fermentation tank can be adjusted according to the detected number and the state of the strains in the fermentation tank, so that the oxygen supply amount in the fermentation tank is always in a suitable range; the influence on the fermentation efficiency and the product quality due to the damage to microbial metabolic balance caused by excessive or insufficient oxygen supply is prevented; fermentation liquid is stirred through the stirring assembly, the gas-liquid contact area is increased, the oxygen transfer rate is increased, and the gas guide assembly and the gas distribution assembly which are communicated with the oxygen inlet pipe are arranged in the stirring assembly, so that when the stirring assembly rotates and stirs in the fermentation tank, the oxygen transfer rate is increased; oxygen conveyed by the oxygen inlet pipe can be uniformly distributed and conveyed into the fermentation tank through the gas guide assembly and the gas distribution assembly, so that the mixing uniformity of fermentation liquor and oxygen is improved.

The invention discloses nanometer calculus bovis gel and a preparation method thereof. The nanometer calculus bovis gel is prepared from calculus bovis and a gel material in a weight ratio of 1: (1000-4000), the calculus bovis is one of natural calculus bovis, calculus bovis cultured in vitro, calculus bovis cultured in vivo and artificial calculus bovis; the gel material is prepared from a gel matrix, a humectant, a pH regulator, a preservative and purified water in a weight ratio of 1: (1-10): (0-3): (0-0.2): (20-50). The preparation method comprises the following steps: S1, dissolving bezoar in a dimethyl sulfoxide solution as an organic phase, dropwise adding the organic phase into an emulsifier-containing water phase under a stirring condition, mixing, continuously stirring, and aging for a certain time to obtain a bezoar nanocrystal solution; and S2, performing high-speed centrifugation and washing on the calculus bovis nanocrystal solution for purification, adding a gel material, and uniformly stirring to obtain the nanometer calculus bovis gel. The chemical composition of the obtained nanometer calculus bovis is not changed in the preparation process, the particle size is uniform, the chemical property is stable, the nanometer calculus bovis is uniformly dispersed in a gel matrix, and the stability is good.

The utility model relates to the field of calculus bovis processing, in particular to a drying device for processing calculus bovis decoction pieces. Comprising a first drying box and a box-shaped support, an opening supporting box is fixedly installed at the top of the first drying box, an air heater body is fixedly installed on the inner top wall of the opening supporting box, an air supply hole is formed in the top of the first drying box, and a second operation long hole and a first operation long hole are formed in the front side of the first drying box; an opening and closing assembly is movably installed in the second operation long hole, a placing assembly is movably installed in the box-shaped support, a first limiting assembly is fixedly installed in the box-shaped support, a fixing assembly is fixedly installed at the top of the box-shaped support, and a positioning assembly is fixedly installed at the top of the first limiting assembly. A rotating assembly is fixedly installed on one side of the box-shaped support, a second limiting assembly is rotationally installed on one side of the first drying box, and a supporting assembly is fixedly installed on one side of the first drying box. The technical problems that drying is inconvenient and the drying effect is poor are solved.

The invention discloses a bezoar quality improving method based on natural pasture environment optimization. According to the method, the internal quality of the calculus bovis is remarkably improved through multi-dimensional cooperative regulation and control. A natural feed basis with balanced nutrition is provided for cattle from soil environment baseline investigation to precise pasture proportioning, and by combining directional cultivation and implantation of genetic engineering strains, the metabolic activity of rumen microorganisms is effectively enhanced, and accumulation of key components for synthesis of calculus bovis is promoted. The linkage application of the intelligent monitoring system and the environment regulation and control device optimizes the living environment of cattle in real time, and cooperates with innovative intervention means such as lavender essential oil and music therapy, so that the stress reaction of cattle herds is remarkably reduced, and the efficient operation of liver metabolic pathways is guaranteed. The directional feeding of the functional lick bricks further enhances the conversion efficiency of the calculus bovis precursor substance, the whole-process data tracing ensures the controllability of the quality formation process, and finally the improvement of the content of effective active ingredients in the calculus bovis and the enhancement of the quality stability are realized.

1. Name of the designed product: packing gift box (bezoar). 2. Use of the designed product: the designed product is used for packing medicine. 3. Design points of the designed product: combination of shape and pattern. 4. Picture or photo showing the design points: perspective view.

This invention provides an in vitro cultured bezoar, its preparation method, and its application, belonging to the field of traditional Chinese medicine preparation technology. The preparation method of this invention involves obtaining a bile-resistant, high-β-glucuronidase-active *Escherichia coli* strain through bile gradient acclimation, which is then combined with *Enterococcus faecalis* to form a functional bacterial community. This community is then cultured in vitro through a three-stage process of proliferation, transformation, and crystallization, followed by gradient calcium ion-induced crystallization and vacuum freeze-drying to obtain in vitro cultured bezoar. This invention aims to solve the problems of low conversion efficiency, uneven crystallization, insufficient content of effective components, and unstable product quality in existing technologies. The obtained in vitro cultured bezoar product has significantly higher bilirubin and conjugated bile acid contents than the standards of the *Chinese Pharmacopoeia*, and the process is stable, controllable, and suitable for industrialization.

The invention discloses a traditional Chinese medicine formula for nourishing liver, improving eyesight, tonifying yang and tonifying kidney, and relates to the technical field of traditional Chinese medicines. The health food is prepared from the following raw materials: 8-18 parts of fructus lycii, 6-11 parts of semen cassiae, 5-8 parts of flos chrysanthemi, 5-7 parts of radix puerariae, 5-6 parts of semen hoveniae, 3-5 parts of fructus hippophae, 3-5 parts of seville orange flower, 3-5 parts of fructus citri sarcodactylis, 4-8 parts of oyster, 4-8 parts of fructus crataegi, 3-12 parts of poria cocos, 3-12 parts of fructus momordicae, 6-8 parts of radix glycyrrhizae and 8-12 parts of fructus corni. The formula covers various medicine properties and effects including nourishing liver to improve eyesight, nourishing kidney yang, benefiting essence and blood, clearing away heat and toxic materials and the like. And the dosage of each medicinal material can be flexibly adjusted according to specific symptoms and physique so as to achieve the optimal treatment effect.

The utility model relates to the field of injectors, in particular to a bezoar strain injector with a leakage-proof design. Comprising a needle cylinder, a piston is installed on the inner wall of the needle cylinder, a needle head is installed at one end of the needle cylinder, an adjusting structure is arranged on one side of the piston and comprises a connecting block, the connecting block is fixedly connected with the piston, a connecting plate is fixedly connected to one side of the connecting block, and a sliding groove is formed in the upper surface of the connecting plate; a positioning block is slidably connected to the inner wall of the sliding groove, a fixing hole is formed in the upper surface of the positioning block, a fixing rod is slidably connected to the inner wall of the connecting plate, and a limiting plate is fixedly connected to one end of the fixing rod. The calculus bovis strain injector with the leakage-proof design has the advantages that the position of the piston can be effectively locked, the piston is prevented from moving due to external factors in the operation, transportation or storage process, the safety of strains is ensured, and the leakage phenomenon is avoided.

The invention discloses application of a safflower liver-clearing thirteen-ingredient pill in preparation of a medicine for repairing liver injury, and belongs to the field of medicines. The safflower liver-clearing thirteen-ingredient pill consists of safflower, cape jasmine, clove, lotus seed, dwarf lilyturf tuber, costus root, medicine terminalia fruit, szechwan chinaberry fruit, red sandalwood, musk, buffalo horn concentrated powder, bezoar and vermilion. The lotus seeds and the costustoot in the safflower liver-clearing thirteen-ingredient pill play a role in repairing liver injury by activating HNF-4alpha, and the ratio of the lotus seeds to the costustoot is 4: (1-3). The research finds that the lotus seed and costus root components in the HHQG can activate the HNF-4alpha, the optimal proportion for activating the HNF-4alpha is preferably selected, and a scientific basis is provided for extracting useful components in medicines and developing natural active small molecular substances.