188 results about "Acetaminophen" patented technology

The invention relates to an application of Danjie emodin in preparation of drugs for preventing or treating drug-induced liver injury. The liver injury is drug-induced liver injury induced by acetaminophen. According to the invention, the effective component Danleaf emodin in the traditional Chinese medicine rhubarb is used for preventing and treating drug-induced liver injury induced by acetamido, and the traditional Chinese medicine composition has the characteristics of safety, reliability and small toxic and side effects. Starting from the whole, multi-target intervention is performed on drug-induced liver injury induced by acetaminophen, the levels of glutamic-pyruvic transaminase, glutamic oxalacetic transaminase and malondialdehyde in plasma are remarkably reduced, the obvious anti-inflammatory and liver cell apoptosis inhibiting effects are achieved, the good clinical application prospect is achieved, and a new way is provided for prevention and treatment of liver injury.

The invention discloses a Fenton-like catalytic system and application thereof in degradation of acetaminophen, and belongs to the technical field of water treatment. The Fenton-like catalytic system is prepared from MXene and H2O2 (hydrogen peroxide). The MXene with nano-scale thickness and submicron or micron-scale transverse size is used as a catalyst, H2O2 is coupled to provide a Fenton-like catalytic system, a larger specific surface area and a larger reaction site are achieved, a Fenton-like catalytic reaction with highly oxyphilic single vacancy or vacancy cluster defects left in an etching reaction of H2O2 and MXene can be brought into full play, and the reaction efficiency is improved. The method has the advantages that the defect sites are accelerated to form oxidation clusters by hydrolyzing or extracting oxygen, the Fenton-like catalytic reaction of H2O2 is facilitated, the acetaminophen can be effectively degraded in the presence or absence of light, and the treatment requirement of the acetaminophen-containing sewage is met.

The invention relates to the technical field of acetaminophen feeding, and particularly provides a spiral feeder for preparing acetaminophen, which comprises a premixing barrel, a spiral feeding mechanism, an integrated locking mechanism, a spiral quantitative feeding mechanism and a synchronous driving mechanism. The multiple spiral quantitative feeding mechanisms are matched with the rotating shaft in the premixing barrel and the premixing conveying piece to conduct premixing spiral feeding on raw materials, when the raw materials are put into the reaction kettle, the spiral feeding machine does not need to be continuously replaced to be connected with a feeding port of the reaction kettle, the problems that operation is tedious, and time and labor are wasted are solved, and the production efficiency is improved. The raw materials can be premixed before entering the reaction kettle, the acetaminophen preparation efficiency is greatly improved, the rotating shaft drives the multiple material stirring sets to stir the raw materials in the corresponding feeding hoppers through the synchronous driving mechanism, and therefore the function of integrated driving of the rotating shaft and the multiple material stirring sets is achieved.

The invention discloses a tannic acid modified tungsten disulfide nanosheet and application thereof in treatment of acetaminophen acute liver injury, the nanosheet takes a tungsten disulfide nanosheet as a core, and the surface of the tungsten disulfide nanosheet is modified with electronegative tannic acid. The nanosheet disclosed by the invention has good stability and biocompatibility, can be used for preparing a nano-drug for treating acetaminophen acute liver injury, and specifically targets and removes active oxygen at a liver injury part through an electrostatic adsorption effect, so that inflammatory response is inhibited, and symptoms caused by the acute liver injury are effectively relieved.

The invention relates to the technical field of acetaminophen crystallization, in particular to a multi-stage continuous cooling crystallization device and method for acetaminophen. The invention provides a multi-stage continuous cooling crystallization method for acetaminophen, which comprises the following steps: S1, at least five stages of continuous cooling crystallization are adopted, and circulating water with a set temperature is injected into a jacket of a crystallization kettle during each stage of cooling crystallization; wherein during the first several stages of crystallization, the difference between the initial temperature of the material entering the crystallization kettle and the initial temperature of the circulating water is 13-25 DEG C; and during the last crystallization, the initial temperature of the material entering the crystallization kettle is 30-35 DEG C. According to the multi-stage continuous cooling crystallization method, different water temperatures are adopted to carry out gradient cooling on the materials, so that the problems of non-uniform grain size and low purity caused by crystal explosion due to large temperature difference between the materials and a refrigerant and high cooling rate in the early stage of cooling are avoided.

The invention discloses a pyranopyridone alkaloid compound as well as a preparation method and application thereof, and belongs to the technical field of medicines. The pyranopyridone alkaloid compound with the activity of resisting the acetaminophen-induced acute liver injury is extracted from a fermentation product of a marine fungus Aspergillus aculeatusWHUF0198, and the pyranopyridone alkaloid compound improves the cell survival rate of mouse hepatocytes treated by acetaminophen and reduces the glutamic-pyruvic transaminase level in a cell supernatant. The pyranopyridone alkaloid compound has the advantages that the pyranopyridone alkaloid compound has the activity of resisting the acetaminophen-induced acute liver injury, and the pyranopyridone alkaloid compound has the activity of resisting the acetaminophen-induced acute liver injury; the pyran pyridone alkaloid compound disclosed by the invention can be used for preparing a medicine for treating acute liver injury. Aiming at the current situation that the types of medicines for treating acute liver injury caused by acetaminophen are deficient at present, the traditional Chinese medicine composition is rich in potential economic benefit.

The invention discloses an anti-phenacetin monoclonal antibody hybridoma cell strain AD, a preparation method and application thereof, and relates to the technical field of food safety immunodetection. The monoclonal antibody hybridoma cell strain is named monoclonal cell strain AD and the number CGMCC19681. The Phe-BA obtained by the hydrolysis of the reaction product of the phenacetin metabolite acetaminophen and ethyl 4-bromobutyrate is used as the hapten, and the hapten is coupled with the carrier protein to prepare the immunogen Phe-BA-BSA. After the mice were immunized with the immunogen Phe-BA-BSA, they were fused with myeloma cells by PEG method, screened by indirect competitive enzyme-linked immunosorbent assay and subcloned five times to obtain hybridoma cell lines. The monoclonal antibody secreted by the cell line can be made into a phenacetin detection kit, which has good affinity and detection sensitivity for phenacetin, and can be used for immunodetection of phenacetin residues in food.

The present application discloses a Fenton-like catalytic system and its application in the degradation of acetaminophen, belonging to the field of water treatment technology. The Fenton-like catalytic system includes MXene and H2O2. The present application adopts MXene with nanometer-scale thickness and submicron or micron-scale lateral dimensions as a catalyst, and couples H2O2 to provide a Fenton-like catalytic system with a larger specific surface area and reaction sites. It can give full play to the Fenton-like catalytic reaction of highly oxygen-philic single vacancies or vacancy cluster defects left in the etching reaction between H2O2 and MXene, accelerate the defect sites to form oxidation clusters by hydrolysis or extraction of oxygen, and is beneficial to the Fenton-like catalytic reaction of H2O2. In the presence or absence of light, effective degradation of acetaminophen can be achieved, meeting the treatment requirements of acetaminophen-containing sewage.

The invention discloses an application of mannose in preparation of a medicine for preventing acetaminophen-induced drug-induced liver injury. The mannose with the mass concentration of 20% is used for intervening acetaminophen-induced (acetaminophen intraperitoneal injection dosage of 300mg / kg) drug-induced liver injury model animals as mice for four weeks in a free water drinking manner. Experiments show that after the mannose is fed for four weeks in advance, the serum ALT and AST levels of APAP-induced drug-induced liver injury model mice can be reduced, the serum inflammatory cytokine level can be reduced, and the pathological injury of liver tissues can be relieved, which indicates that the mannose can protect the APAP-induced drug-induced liver injury. The invention provides the application of mannose in the APAP-induced drug-induced liver injury, and a new prevention thought is provided for the APAP-induced drug-induced liver injury.

This invention discloses a polyethylene glycol-modified magnesium boride nanosheet and its application in treating acute liver failure and hepatic encephalopathy caused by acetaminophen. The nanosheet uses magnesium boride nanosheets as a core, with polyethylene glycol modified on the surface to improve biocompatibility. The nanosheet of this invention exhibits good antioxidant properties and can be used to prepare nanomedicines for treating acute liver failure and / or hepatic encephalopathy caused by acetaminophen. It generates reducing hydrogen gas through a hydrolysis reaction, effectively scavenging reactive oxygen species at the site of liver failure, thereby inhibiting inflammatory responses and effectively alleviating symptoms caused by acute liver failure.

The invention discloses synthesis and pharmacodynamic toxicological research of an acetaminophen derivative, the acetaminophen derivative has a structure as shown in the following formula (I) or a pharmaceutically acceptable salt thereof, in the formula (I), R1 is selected from-OH, F, Cl or Br; r2 is selected from S or O; when R2 is O, R1 is not-OH; and preferably, R2 is S. The invention designs and synthesizes a series of APAP-based novel derivatives from the perspective of changing the metabolic pathway of the drug by carrying out reasonable drug modification on APAP, and reduces the toxic and side effects of the original drug while exerting the biological activity similar to or higher than that of the original drug.

It is described and claimed a pharmaceutical composition comprising celecoxib and acetaminophen as active ingredients, wherein the pharmaceutical composition is an immediate release coated tablet. The pharmaceutical composition of the invention is particularly stable and allows the oral administration in a single dosage unit of two active ingredients. It is further provided a process for manufacturing the pharmaceutical composition, as well as the use of said pharmaceutical composition for the treatment of pain, it provides analgesia and a reduction of adverse effects.

The invention provides rhizoma alismatis purified polysaccharide as well as a preparation method, an identification method and application thereof, the rhizoma alismatis purified polysaccharide is a functional component with a novel structure in a traditional Chinese medicine rhizoma alismatis water extract obtained by further extraction and purification, the administration efficiency is effectively improved, and the pharmacodynamic substances are clarified; in-vivo and in-vitro experiments show that the polysaccharide can improve the antioxidant capacity of the liver and relieve inflammatory response; synthesis and metabolism of liver bile acid can be adjusted, cholestasis of the liver is relieved, and bile acid circulation is promoted so as to relieve acute liver injury caused by acetaminophen; the effect of promoting the recovery of liver injury patients is obvious; and the compound also can be used as prebiotics to improve the homeostasis of intestinal microorganisms and promote the synthesis of short-chain fatty acids so as to have beneficial effects on the liver.

The invention belongs to the technical field of medicines, and particularly relates to application of isosalicin in preparation of liver injury medicines. The invention provides the application of the isosalicin in the aspect of preparing the liver injury medicine for the first time. The isosalicin is isosalicin (the molecular formula is C13H18O7; the compound has a molecular weight of 286.28, hereinafter referred to as IS), and the medicine IS does not show toxicity in an investigated concentration range (6.25-100 [mu] M), can significantly improve the cell survival rate of acetaminophen induced damaged parenchymal hepatic cells AML-12 at the investigated concentration of 6.25-25 [mu] M, has a significant liver protection effect, and has a good application prospect in preparation of medicines for preventing and treating liver injury.

The invention discloses a traditional Chinese medicine preparation with a liver protection effect and a preparation method and application thereof, and belongs to the technical field of application of medicine extracts. The traditional Chinese medicine preparation is prepared from a gallnut extract, an auxiliary material and an ethanol solution, the mass ratio of the gallnut extract to the auxiliary material is 1: (1-2), and the ratio of the total mass of the gallnut extract and the auxiliary material to the mass volume of the ethanol solution is 100g: (2-5) mL. The traditional Chinese medicine preparation disclosed by the invention has the advantages that the antioxidant capacity of mice is improved, the anti-inflammatory capacity of mice is enhanced, the liver injury of the mice caused by toxicants such as acetaminophen and carbon tetrachloride is relieved, and the intestinal flora structure and liver metabolism condition of the mice are improved; when the compound is used for preparing the liver protection preparation, an antioxidant signal channel of a body can be activated, and oxidation and fibrosis damage of the liver can be relieved, so that the liver function of the body is improved.

The invention provides an electrode for an implantable biosensor and application of the electrode, a conducting layer of the electrode is located on an insulating substrate of the biosensor, a sensing layer and a limiting layer are sequentially arranged on the conducting layer of the electrode, the sensing layer comprises enzyme required by reaction, and the sensing layer further comprises cationic polymer. The biosensor provided by the invention realizes good linear correlation of testing under low potential, obviously reduces interference of acetaminophen and other interfering substances on test signals under the condition of low-potential testing, and improves the accuracy of detection.

A chemical composition for an oral pharmaceutical product is described having a therapeutically effective amount of one or more active pharmaceutical ingredients (API) including acetaminophen and ibuprofen in combination with a cannabidiol (CBD) isolate.

A composition comprises an alkali metal salt of a first pharmaceutical ingredient; and a second pharmaceutical ingredient, wherein the second pharmaceutical ingredient is chemically incompatible with the first pharmaceutical ingredient, and the composition is an aqueous solution. The first active pharmaceutical ingredient can comprise ibuprofen or naproxen. The second pharmaceutical ingredient can comprise acetaminophen.

Disclosed in the present application are a method and drug for preventing or treating a neurodegenerative disease, whereby a therapeutically effective amount of gliclazide or a pharmaceutically acceptable salt thereof or a combination of gliclazide or a pharmaceutically acceptable salt thereof and acetaminophen or a pharmaceutically acceptable salt thereof is used or comprised. The method and drug of the present invention can significantly alleviate symptoms such as hyposmia, cognitive dysfunction, and psychiatric symptoms in patients with neurodegenerative diseases that cannot be treated with existing drugs, and can be particularly used for controlling the progression of neurodegenerative diseases.

This specification describes softgel capsules comprising a filler material and a shell composition. The filler material may contain alkali metal salts of NSAIDs and acetaminophen, but may not contain povidone. The shell composition may contain a film-forming material. The softgel capsules may have at least about 99% assay stability at room temperature after 12 months.

The invention discloses an application of distension hippocampus submicron powder in preparation of a composition for acetaminophen-induced liver injury. The application of the superfine powder form of the hippocampus japonicus which can be cultured on a large scale to the APAP liver injury is developed, the effect is equivalent to or superior to that of NAC, the advantages of dose dependence and multi-target protection are achieved, sustainable utilization of marine medicinal materials is promoted, and a novel, safe and effective strategy is provided for clinical prevention and treatment of the liver injury.

Pharmaceutical formulations containing acetaminophen and sulfoalkyl ether cyclodextrin are described. The formulation includes acetaminophen; and sulfoalkyl ether cyclodextrin, wherein the molar ratio of sulfoalkyl ether cyclodextrin to acetaminophen is in the range of about 0.01 to about 2. The formulations can be prepared in an injectable form for mitigating or treating fever or alleviating pain in a patient.

The invention relates to the technical field of traditional Chinese medicine, in particular to a Chinese and western medicine composition for treating wind-heat type common cold and a preparation method and application thereof. The traditional Chinese and western medicine composition comprises the following components in parts by weight: 4-8 parts of a traditional Chinese medicine extract A; 3-7 parts of a traditional Chinese medicine extract B; 5-10 parts of a traditional Chinese medicine extract C; 1-5 parts of a western medicine composition D; the traditional Chinese medicine extract A is prepared by performing CO2 supercritical extraction and volatile oil clathration on honeysuckle; the traditional Chinese medicine extract B is obtained by carrying out enzymolysis on honeysuckle and isatis root; the traditional Chinese medicine extract C is prepared from honeysuckle and radix isatidis through ultrasonic extraction; the western medicine composition D is prepared from raw material components including calculus bovis factitius, acetaminophen and amantadine hydrochloride. The Chinese and western medicine composition is simple in component, can enhance the anti-inflammatory, cough-relieving and phlegm-eliminating effects, and obviously improves various symptoms caused by cold.

The invention relates to the technical field of pharmaceutical preparations, in particular to an ibuprofen and acetaminophen composition and a preparation method thereof. The invention aims to meet the requirements of patients on rapid pain relief and long-term effectiveness. The first aspect of the invention is to provide an ibuprofen and acetaminophen composition, the ibuprofen and acetaminophen composition comprises an ibuprofen-containing slow release layer, an acetaminophen-containing slow release layer and a drug-containing quick release layer which are stacked, the ibuprofen-containing slow release layer comprises a slow release layer ibuprofen and a first slow release auxiliary material, and the drug-containing quick release layer comprises a drug-containing quick release layer. The acetaminophen-containing sustained-release layer comprises a sustained-release layer acetaminophen and a second sustained-release auxiliary material, and the drug-containing quick-release layer comprises a quick-release layer ibuprofen, a quick-release layer acetaminophen and a quick-release auxiliary material. The second purpose of the invention is to provide a method for preparing the ibuprofen and acetaminophen composition.

The invention relates to modified release oral formulations of therapeutic agents, including gamma hydroxybutyrate (GHB), paracetamol, codeine or oxycodone, which are resistant to alcohol induced dose dumping. Provided are formulations that have improved resistance to rapid release of the active ingredient in the presence of increasing amounts of alcohol. Also provided are formulations that can reduce or prevent the release of the active ingredient following exposure to alcohol-containing media. The invention also relates to methods of making the formulations, and methods of their use for the treatment of sleep disorders such as apnea, sleep time disturbances, narcolepsy, cataplexy, sleep paralysis, hypnagogic hallucination, sleep arousal, insomnia, and nocturnal myoclonus.

A chemical composition for an oral pharmaceutical product is described having a therapeutically effective amount of one or more active pharmaceutical ingredients (API) including acetaminophen in combination with a cannabidiol (CBD) isolate.

The present disclosure is directed to an improved method of treating mild pain in humans using a pharmaceutical dosage form comprising acetaminophen in admixture with naproxen.

The invention belongs to the technical field of biological medicines, and relates to an application of Lindenamarin in medicines for preventing, relieving or / and treating acetaminophen-induced liver injury or / and acute hepatic failure. According to the application disclosed by the invention, it is found for the first time that Linocinnamarin can be used for preventing, relieving or / and treating APAP-induced liver injury or / and acute liver failure; in addition, the invention also finds that the Linocinnamarin can improve liver cell apoptosis, inflammatory response and oxidative stress reaction caused by APAP-induced liver injury or / and acute liver failure, and also finds that the Linocinnamarin can improve the liver cell apoptosis, inflammatory response and oxidative stress reaction caused by APAP-induced liver injury. Therefore, the invention provides a new treatment thought for clinically treating the APAP-induced liver injury or / and acute liver failure.

A composition for the treatment of chronic pain and mixed pain sites may include a serotonin and norepinephrine reuptake inhibitor; a non-steroidal anti-inflammatory agent; optionally acetaminophen; optionally oxcarbamazepine; optionally an oral opioid antagonist; optionally an antacid; optionally an anti-epileptic; and optionally an opioid. A method for treating chronic pain and mixed pain sites may include administering, to a patient in need, a therapeutically effective dosage of the composition.

A novel compound complex that has no side effects on a liver and is used to alleviate the toxicity of an acetaminophen (APAP) drug to the liver. The composition of the compound consists of (a) acetaminophen in a pharmaceutically effective amount and (b) a commonly-used safe and pharmaceutically acceptable excipient that can be combined with one or more of two drugs to reduce the toxicity of a drug metabolized by the hepatic enzyme CYP2E1 in the liver.The compound is selected from the following group: Tween 20, microcrystalline cellulose, dicalcium phosphate, polyoxyethylene 23 lauryl ether, saccharin, mannitol, polyoxyethylene alkyl ether, sucralose, pyrrolidone, sodium starch glycolate, S100 acrylic resin, sodium carboxymethylcellulose, polyoxyethylene polyoxyethylene, menthol, low-substituted propylcellulose hydrocarbon, pregelatinized starch, Dextrates NF hydrate, citric acid, polyoxyethylene castor oil, colloidal silicon, aliphatic polyethylene glycol monostearate ester, sorbic acid, lemon oil, hydroxypropylcellulose, sorbitol, acesulfame potassium, hypromellose phthalate, lactose monohydrate, maltodextrin, Brij 58, Brij 76, Tween 80, Tween 40, PEG 400, Peg 4000, PEG 2000, and the like, so as to reduce the side effects caused by acetaminophen on the liver.