32 results about "Calculus bovis" patented technology

The invention relates to the technical field of traditional Chinese veterinary medicines, in particular to a veterinary antiviral traditional Chinese medicine composition and a preparation method thereof.The traditional Chinese medicine composition is prepared from, by weight, 20-40 parts of gypsum and 15-30 parts of rhizoma anemarrhenae; 15-30 parts of cornu bubali; 10-15 parts of manyleaf paris rhizome; 10-15 parts of radix paeoniae rubra; 10 to 15 parts of moutan bark; 10 to 15 parts of uncaria rhynchophylla; 0.3-1 part of calculus bovis factitius; 15 to 30 parts of magnet; 1-3 parts of benzoin; 10-15 parts of radix trichosanthis; and 10-15 parts of cape jasmine. The preparation method comprises the following steps: decocting the traditional Chinese medicines to prepare traditional Chinese medicine decoction, and concentrating overnight filtrate under reduced pressure to obtain traditional Chinese medicine fluid extract; and adding clinically acceptable auxiliary materials into the traditional Chinese medicine fluid extract, and preparing a clinically acceptable oral traditional Chinese medicine preparation by adopting a conventional preparation mode. The veterinary antiviral traditional Chinese medicine composition provided by the invention has a good treatment effect on viral diseases of livestock according to the principle of dialectical treatment of traditional Chinese veterinary medicines, can be used for replacing western medicines, and effectively avoids the problems of food safety and drug resistance caused by drug residues of the western medicines.

The invention belongs to the technical field of in-vitro cultured calculus bovis, and provides in-vitro cultured calculus bovis and a preparation method thereof. The preparation method comprises the following steps: (1) separating cells; (2) primary culture; (3) cell inoculation and cultivation: adding the serum-free culture medium into the carrier matrix, putting the carrier matrix into a reactor, and performing cell inoculation on the carrier matrix after passage; the inoculated culture comprises a proliferation period; a synthesis period; a crystallization period; and (4) collecting and purifying the calculus bovis, namely stopping culturing after 45 days, and sequentially collecting, cleaning, degreasing, drying and crushing the calculus bovis. The preparation method aims at solving the problems of long culture period, unstable content of effective components, high production cost, large batch difference and the like in the existing in-vitro calculus bovis culture technology by optimizing a culture medium formula, regulating and controlling a culture process and a purification process.

The invention belongs to the technical field of traditional Chinese medicine (Tibetan medicine), and particularly relates to a Tibetan medicine composition for treating new coronavirus infection and application of the Tibetan medicine composition. The invention discloses a Tibetan medicine composition for treating new coronavirus infection and application of the Tibetan medicine composition. The composition is prepared from the following components in parts by weight: 100 to 700 parts of fructus chebulae, 10 to 80 parts of radix aconiti lateralis, 10 to 60 parts of radix aucklandiae, 50 to 600 parts of rhizoma acori calami, 10 to 50 parts of Muslim myrrh, 0.01 to 50 parts of calculus bovis factitius and 0.01 to 50 parts of artificial musk. The composition can inhibit the mRNA expression of the N gene and the ORF1ab gene after the SARS-CoV-2 virus infects the Vero cell, so that the treatment on the novel coronavirus infection is realized.

The invention provides a high-fidelity calculus bovis and a preparation method thereof, and belongs to the technical field of traditional Chinese medicines. According to the technical scheme provided by the invention, the high-fidelity calculus bovis is accurately prepared by taking the mean value of the contents of various components of the natural calculus bovis as a reference and accurately measuring the contents of various components in the raw materials, fully utilizing the original components of the ox bile or ox gall powder, not adding other non-calculus bovis components and combining the existence forms of the components. The problems that existing artificial calculus bovis is greatly different from natural calculus bovis in efficacy, and toxic and side effects are relatively high are solved. The shape, the forming process and the components of the product are highly similar to those of natural calculus bovis; the medicine effect of the calculus bovis is improved, and the production cost is reduced.

The invention discloses a traditional Chinese medicine manufacturing knowledge extraction method and device based on a small-sample fine-tuning large language model and prompt engineering and electronic equipment. The method comprises the following steps: firstly, acquiring low-quality non-standard real text data in the field of manufacturing of the same-kernel calculus bovis heart-clearing pills, and generating a high-quality standard text by utilizing a large language model to construct a mixed evaluation set; then, a few-sample training set is constructed through human-in-loop mechanism iteration, fine adjustment is carried out on a GPT-4omini model through OpenAI API, and fine adjustment parameters comprise the learning rate 1e-4, the batch size 5 and the training round number 5; meanwhile, a structured prompt template for clearly specifying entity types and relationships is constructed; and after model reasoning, automatically outputting a structured result in a JSON-LD format, analyzing the structured result, and storing the analyzed structured result in a Neo4j graph database to construct a knowledge graph. According to the method, through combination of few-sample fine adjustment and prompt engineering, the sensitivity to data quality is remarkably reduced, and the knowledge extraction problem of non-standard texts with professional term nesting and structure breakage in the field of traditional Chinese medicine manufacturing is effectively solved.

The invention belongs to the technical field of biochemical pharmacy, and particularly relates to a compound bezoar composition, decoction piece type compound bezoar and a preparation method of the decoction piece type compound bezoar. The compound calculus bovis composition provided by the invention comprises 94-96% by mass of main agents and 8 kinds of calculus bovis intermediates, the mass content of the auxiliary agent is 4-6%, and the auxiliary agent is six commercially available finished product combined cholic acid. The bilirubin content of the bezoar intermediate used in the invention is increased by more than 30% and the yield is increased by more than 25% compared with the existing biochemical reaction process of oxgall. The DPPH free radical scavenging rate of the compound bezoar composition reaches 89.6% + / -2.1% and is increased by 25.7-36.9% compared with 58.3% + / -3.5% of a product prepared from ox bile, and through t inspection, p is smaller than 0.01 (n is equal to 5). Free cholic acid intervention is strictly prohibited, lithocholic acid addition is completely eradicated, and the composition has the advantages of being high in bilirubin content, high in oxidation resistance and high in biological activity and adapts to the physiological characteristics of the human body.

The invention discloses a traditional Chinese medicine composition for inhibiting and fading scar hyperplasia and a preparation method of the traditional Chinese medicine composition, and belongs to the field of traditional Chinese medicine compositions for fading scars. 5 to 15 parts of a gel matrix; 10 to 25 parts of an oil phase component; 3-8 parts of an emulsifier and a thickener; and the balance of water. Wherein the active traditional Chinese medicine component consists of 1-5 parts of calculus bovis factitius, 1-3 parts of artificial musk, 3-10 parts of cowherb seed, 3-10 parts of golden cypress, 2-8 parts of frankincense and 2-8 parts of myrrh. The traditional Chinese medicine composition for inhibiting and fading scar hyperplasia and the preparation method of the traditional Chinese medicine composition have the beneficial effects that the traditional Chinese medicine composition for inhibiting and fading scar hyperplasia and the preparation method of the traditional Chinese medicine composition are provided, all the medicines are combined to jointly achieve the effects of promoting blood circulation to remove blood stasis, dredging collaterals, removing stasis, resisting inflammation and promoting tissue regeneration and directly refer to the pathogenesis core of scar hyperplasia, and an oil-in-water (O / W) latex dosage form is adopted, so that the traditional Chinese medicine composition has the refreshing effect of gel and the moistening effect of cream, and is easy to coat and good in air permeability.

The invention discloses a bezoar quality improving method based on natural pasture environment optimization. According to the method, the internal quality of the calculus bovis is remarkably improved through multi-dimensional cooperative regulation and control. A natural feed basis with balanced nutrition is provided for cattle from soil environment baseline investigation to precise pasture proportioning, and by combining directional cultivation and implantation of genetic engineering strains, the metabolic activity of rumen microorganisms is effectively enhanced, and accumulation of key components for synthesis of calculus bovis is promoted. The linkage application of the intelligent monitoring system and the environment regulation and control device optimizes the living environment of cattle in real time, and cooperates with innovative intervention means such as lavender essential oil and music therapy, so that the stress reaction of cattle herds is remarkably reduced, and the efficient operation of liver metabolic pathways is guaranteed. The directional feeding of the functional lick bricks further enhances the conversion efficiency of the calculus bovis precursor substance, the whole-process data tracing ensures the controllability of the quality formation process, and finally the improvement of the content of effective active ingredients in the calculus bovis and the enhancement of the quality stability are realized.

The invention belongs to the technical field of microorganisms, and particularly relates to a bacterial strain for promoting formation of calculus bovis, a microbial agent and application of the bacterial strain, the bacterial strain is classified and named as Escherichia fergusonii, the bacterial strain is preserved in China General Microbiological Culture Collection Center on May 13, 2025, and the preservation number is CGMCC No.34526. The invention further discloses a preparation method of the bacterial strain for promoting formation of calculus bovis. The strain can be used as a transformation strain for in-vitro cultivation of calculus bovis and can also be used as an implantation strain for artificial in-vivo cultivation of calculus bovis, and the problems that in the process of artificial in-vitro cultivation or in-vivo cultivation of calculus bovis, thalli are low in bile tolerance and enzyme production activity, short in survival time in ox bile and low in calculus bovis forming efficiency are solved.

The invention discloses eye protection liquid and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine external preparations. The eye protection liquid is prepared from a chrysanthemum extract, borneol, calculus bovis factitius, venenum bufonis, realgar, a mint extract, a pipewort extract, a feather cockscomb seed extract, a butterflybush flower extract, pearl powder and purified water according to a specific weight part ratio, and is prepared by soaking, distilling, filtering and filling. The traditional Chinese medicine composition can rapidly permeate into eyes and directly enter focus, can relieve and treat various eye diseases such as presbyopia, myopia, amblyopia, cataract and the like, has the effects of soothing liver and relieving depression, promoting blood circulation and dredging collaterals, tonifying kidney and nourishing yin, supplementing optic nerve nutrition and improving microcirculation around the eyes, has the total effective rate of 100% and the cure rate of 80-95%, and is free of side effects and drug resistance and convenient to use.

The utility model relates to the field of injectors, in particular to a bezoar strain injector with a leakage-proof design. Comprising a needle cylinder, a piston is installed on the inner wall of the needle cylinder, a needle head is installed at one end of the needle cylinder, an adjusting structure is arranged on one side of the piston and comprises a connecting block, the connecting block is fixedly connected with the piston, a connecting plate is fixedly connected to one side of the connecting block, and a sliding groove is formed in the upper surface of the connecting plate; a positioning block is slidably connected to the inner wall of the sliding groove, a fixing hole is formed in the upper surface of the positioning block, a fixing rod is slidably connected to the inner wall of the connecting plate, and a limiting plate is fixedly connected to one end of the fixing rod. The calculus bovis strain injector with the leakage-proof design has the advantages that the position of the piston can be effectively locked, the piston is prevented from moving due to external factors in the operation, transportation or storage process, the safety of strains is ensured, and the leakage phenomenon is avoided.

The invention discloses a compound paracetamol and amantadine hydrochloride capsule containing caffeine microcapsules, which relates to the technical field of medicines and comprises paracetamol, amantadine hydrochloride, calculus bovis factitius, pharmaceutic adjuvants and functional microcapsule units. The functional microcapsule unit has a three-layer structure: a core material taking caffeine and microcrystalline cellulose as a core, an ethyl cellulose controlled release layer and a quick release layer containing chlorpheniramine maleate. According to the structure, time sequence controlled release of drugs is achieved by synthesizing a polymer coating material, chlorpheniramine maleate is quickly released when encountering gastrointestinal fluid to quickly resist allergy, and caffeine starts to be slowly released after being effectively delayed to the intestinal environment, so that the time when the plasma concentration reaches the peak tends to be synchronous with the time when chlorpheniramine maleate reaches the peak; the drowsiness side effect can be effectively resisted.

The novel fixing frame comprises a bottom plate and side plates, the side plates are arranged on the left side and the right side of the bottom plate in a welded mode, the side plates are provided with handrails and second door plates, the handrails are arranged above the second door plates, hollow grooves are formed between the second door plates and the handrails, and the second door plates are arranged in the hollow grooves. The side plates are provided with limiting mechanisms matched with the hollowed-out grooves. The limiting mechanism comprises a sliding rail, a sliding block and a steel pipe, the sliding block is arranged on the sliding rail in a sliding mode, a clamp is welded to the sliding block, and the steel pipe penetrates through the clamp and the hollowed-out groove. The novel fixing frame for artificial cultivation of calculus bovis is simple in structure, practical in function and ingenious in design, and effectively solves the problem that an existing fixing frame is not provided with a side face door plate for an operation, and inconvenience is brought to the operation process.

A method for screening and efficiently cultivating bezoar strains belongs to the field of bezoar strain screening, and comprises the following steps: step 1, inoculating a culture medium with low-pathogenicity Escherichia coli for culturing, comparing and observing, picking out single colonies with good growth vigor for subculture, and preserving the strains after culture; 2, taking the primarily screened preserved strain, reviving in four regions of an LB solid culture medium by marking lines, selecting a single colony, putting the single colony into a first gradient liquid bile culture medium, culturing, measuring OD600, and if OD600gt is detected, determining that the single colony is not detected; and 0.6, the strain can be placed in a liquid bile culture medium of the next gradient, and the strain which can grow in the three gradients can be inoculated into fresh oxgall for culture. The method has the advantages that the escherichia coli strain with high beta-glucuronidase activity for efficiently cultivating calculus bovis can be obtained, in-vitro cultivation verifies that the escherichia coli strain has bile resistance, calculus bovis analogues can be obtained, and the physicochemical properties of the calculus bovis analogues are similar to those of natural calculus bovis.

The invention relates to a preparation method for producing calculus bovis by a chemical fermentation technology, which is characterized in that animal bile such as cattle (pigs, sheep and poultry) is used as a raw material, and the calculus bovis is produced by a modern process technology. The composition is prepared from the following components in parts by weight: 8 to 15 parts of taurine, 13 to 26 parts of ox gall powder, 1 to 12 parts of cholic acid, 1 to 17 parts of zinc sulfate, 1 to 15 parts of bilirubin, 20 to 40 parts of calcium gluconate, 20 to 38 parts of deoxycholic acid, 1 to 16 parts of cholesterol, 0.1 to 4.5 parts of fatty acid, 0.05 to 0.95 part of amylase and 0.05 to 2.22 parts of honeysuckle flower extract.

The invention belongs to the technical field of traditional Chinese medicine authenticity identification and quality control, and particularly relates to an artificial intelligence calculus bovis trace element quality attribute rapid detection and discrimination method and device and electronic equipment. The method comprises the following steps: firstly, quickly and nondestructively acquiring calculus bovis comprehensive element fingerprint spectrum data by adopting a high-sensitivity X-ray fluorescence spectrum, and constructing a calculus bovis database; secondly, evaluating the quality consistency of the calculus bovis according to the similarity coefficient; and finally, establishing a back propagation neural network and a multi-layer sensor model, and realizing rapid and accurate discrimination of the natural product and the artificial product of the calculus bovis. Compared with a traditional method, the method has the advantages of rapidness, no damage, low cost and high accuracy, and is suitable for quality monitoring and market supervision of traditional Chinese medicinal materials.

The utility model relates to the field of trays for selecting calculus bovis, in particular to a tray for selecting calculus bovis. Comprising a placing disc, an auxiliary structure is arranged on the inner wall of the placing disc, the auxiliary structure comprises two sliding grooves, the two sliding grooves are formed in the inner wall of the placing disc, a connecting groove is formed in one end of the placing disc, sliding blocks are slidably connected to the inner walls of the sliding grooves, and magnetic sheets are fixedly connected to the bottom walls of the sliding grooves. And iron sheets are fixedly connected to the ends, close to the magnetic sheets, of the sliding blocks, placing plates are fixedly connected to the sides, close to each other, of the two sliding blocks, notches are formed in the inner walls of the placing plates, and moving blocks are fixedly connected to the two sides of the ends, close to the connecting grooves, of the placing plates. The material tray for selecting the calculus bovis has the advantages that the special container is designed, cattle gastric juice can be independently contained, the direct contact between the cattle gastric juice and the material tray is avoided, the material tray is prevented from being eroded by the cattle gastric juice, and the long service life of the material tray and an electronic scale is ensured.

The utility model relates to the technical field of bezoar forming induction, and discloses a bezoar forming induction device which comprises a first body and a second body, the outer side of the surface of the bottom end of the first body is fixedly sleeved with a first connecting mechanism, and the top of the second body is provided with a second connecting mechanism. Movable limiting mechanisms are movably clamped to the outer sides of the surfaces of the second connecting mechanism and the first connecting mechanism, each of the first connecting mechanism and the second connecting mechanism comprises an annular frame, and a fixing groove is formed in the side, close to the first body or the second body, of each annular frame; through mutual cooperation of the first connecting mechanism, the second connecting mechanism and the movable limiting mechanism, the first body and the second body can be stably connected, and otherwise, the first body and the second body can be quickly separated; the adsorption balls can be conveniently implanted into the inner sides of the first body and the second body, and the operation is convenient.

Provided is a compound hydrocortisone and neomycin sulfate granule, including the following components in parts by mass: 140 parts of acetaminophen, 1 part of chlorpheniramine maleate, 1.2 parts of methylephedrine hydrochloride, 2 to 2.5 parts of an inclusion stabilizer, 3.0 parts of artificial calculus bovis, and 0.5 to 1 parts of a caramel. In a method for preparing the compound hydrocortisone and neomycin sulfate granule, natural Chinese medicinal herbs are subjected to extraction to obtain natural stabilizers for stabilizing low-concentration acetaminophen and chlorpheniramine maleate, and the natural stabilizers are encapsulated with hydroxypropyl-β-cyclodextrin with a specific degree of substitution (DS).

The invention relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition for treating osteoarthritis and application of the traditional Chinese medicine composition in pharmacy. The traditional Chinese medicine composition is prepared from astragalus membranaceus, pseudo-ginseng, angelica sinensis, radix paeoniae rubra, white paeony root stir-fried with bran, stephania tetrandra, rhizoma alismatis, semen coicis, poria cocos, salvia miltiorrhiza, honeysuckle stem, rhizoma atractylodis, radix achyranthis bidentatae, dendrobe, polygala tenuifolia, processed pinellia ternate, thunberg fritillary bulb, calculus bovis factitius and liquorice according to a specific proportion, and has the effects of promoting blood circulation to remove blood stasis, clearing damp, reducing phlegm and activating meridians to stop pain. Experiments show that the traditional Chinese medicine composition can significantly improve the joint function of a patient with knee osteoarthritis and reduce the level of inflammatory factors.

The invention belongs to the field of microorganisms, and particularly relates to a screening culture medium and a screening method of beta-glucuronidase producing bacteria. The screening culture medium for producing the beta-glucuronidase bacteria is prepared from the following raw materials in parts by weight: 3 to 10 parts of ox bile crude extract, 12 to 24 parts of ammonium nitrate, 10 to 20 parts of sodium chloride, 1 to 10 parts of dipotassium phosphate, 1 to 8 parts of quercetin and 0.1 to 0.5 part of 5-bromo-4-chloro-3-indolyl-beta-D-gluconic acid glycoside. The crude ox bile extract is an ethanol extract of ox bile powder. According to the screening culture medium disclosed by the invention, the beta-glucuronidase producing bacteria can be rapidly separated from the ox bile, and the separated beta-glucuronidase producing bacteria are used for preparing the calculus bovis, so that the calculus bovis with high yield and quality can be obtained, and the production efficiency of the calculus bovis is improved.

This invention provides a compound traditional Chinese medicine composition, its preparation method, and its application in the preparation of drugs for treating allergic rhinitis, belonging to the field of traditional Chinese medicine technology. The compound traditional Chinese medicine composition of this invention includes: Antrodia camphorata, Paeonia suffruticosa, Cynanchum paniculatum, Cicadae periostracum, Calculus bovis, Borneol, and Mentha haplocalyx. Antrodia camphorata, the principal ingredient, fundamentally regulates immunity and reduces inflammation and swelling. Paeonia suffruticosa, Cynanchum paniculatum, and Cicadae periostracum assist in anti-allergy and clearing heat and wind. Calculus bovis and Borneol are adjuvant ingredients that resolve phlegm, open the orifices, clear heat, and relieve pain. Mentha haplocalyx guides the medicine upwards and relieves local symptoms. This invention treats allergic rhinitis using a combination of internal and external application. Internal administration exerts a systemic regulatory effect and enhances immunity, while external application to the nose quickly relieves symptoms. The comprehensive formula addresses both the root cause and symptoms, with the various drug components synergistically enhancing anti-inflammatory, anti-allergic, and immunomodulatory effects to achieve the therapeutic effect of treating allergic rhinitis.

The invention relates to the technical field of pharmaceutical preparations, and discloses a formula and a preparation method of a bezoar detoxification capsule, and the method comprises the following steps: crushing and screening artificial bezoar, nano realgar, glycyrrhizic acid, rheum officinale, scutellaria baicalensis, platycodon grandiflorum and liquorice, performing ultrasonic extraction on gypsum, dissolving borneol, performing ultrasonic extraction, and drying to obtain the bezoar detoxification capsule. Crushing the honeysuckle flower extract, the fructus forsythiae extract, the herba violae extract, the radix isatidis extract and the fructus arctii extract; mixing the treated gypsum powder, rhubarb powder, scutellaria baicalensis powder, platycodon grandiflorum powder, liquorice powder, honeysuckle extract powder, fructus forsythiae extract powder, philippine violet herb extract powder, isatis root extract powder and burdock extract powder, preparing a solution, spraying the solution on the mixed powder to prepare a soft material, granulating, adding treated calculus bovis factitius powder, nano realgar powder, glycyrrhizic acid powder and borneol powder, uniformly mixing, and granulating to obtain a finished product. The bezoar detoxification mixture filled capsule is obtained. The calculus bovis detoxification capsule has the effects of clearing away heat and toxic materials, reducing toxicity and improving the component extraction rate and utilization rate.

The invention relates to a method for preparing bionic calculus bovis from engineering bacteria, the bionic calculus bovis and application of the bionic calculus bovis, and belongs to the technical field of traditional Chinese medicine raw material preparation. According to the method, natural oxgall is used as a fermentation substrate, a fermentation reaction system is used for preparing the bionic calculus bovis, and the fermentation reaction system uses synthetase high-expression engineering bacteria as a fermentation strain for direct in-vitro fermentation; the preparation method of the synthase high-expression engineering bacterium comprises the following steps: constructing an overexpression plasmid, introducing the plasmid into a vector to construct an engineering strain, and carrying out expanding culture to obtain the synthase high-expression engineering bacterium. The bionic calculus bovis prepared by the method is highly consistent with natural calculus bovis in component, the content of cholic acid (CA) is 8.5%-20.0%, the content of deoxycholic acid (DCA) is 2.0%-6.5%, the fingerprint similarity is greater than or equal to 88.0%, and pharmacological experiments show that the bionic calculus bovis prepared by the method has the same acting effect as the natural calculus bovis and is superior to that of each pair of calculus bovis.

The utility model relates to the technical field of calculus bovis cultivation, and discloses a bioreactor for in-vitro cultivation of calculus bovis, which comprises a reactor body, a material uniformizing mechanism arranged in an inner cavity of the reactor body, a plurality of groups of oxygen supply tanks arranged at the upper end of the reactor body, and a first electromagnetic valve arranged at the lower end of each group of oxygen supply tank, an oxygen supply mechanism is arranged at the bottom of the inner cavity of the reactor body and is arranged below the refining mechanism; through cooperation of the oxygen supply mechanism, the reactor body and the material uniformizing mechanism, oxygen can be uniformly introduced into the bottom of the inner cavity of the reactor body through the oxygen supply mechanism, so that the contact range between the oxygen and cells is expanded, and meanwhile, under the action of the material uniformizing mechanism, the oxygen can flow in the reactor body along with bile, so that the bile is uniformly dispersed. Therefore, the oxygen can be uniformly supplied to the cells, and the mixing uniformity of the bile and various raw materials for promoting cell differentiation is improved, so that the cultivation efficiency of the calculus bovis is improved.

The invention discloses a method for increasing the yield of bezoar through specific forage combination feeding. According to the method, through scientific treatment and directional feeding of the ox gall powder residues, appropriate physiological conditions are created for bezoar formation. Active ingredients in the treated residues are more easily absorbed by cattle, the gallbladder contraction rhythm is mildly adjusted, cholestasis is induced, and cholesterol is crystallized and separated out, which is the core mechanism of calculus bovis generation; meanwhile, due to the interval feeding rhythm, continuous stimulation is guaranteed, excessive burden cannot be caused to the hepatobiliary system of the cattle, the calculus bovis can be gradually formed in a stable physiological environment, the yield of the calculus bovis is increased from the source, and the double advantages of resource recycling and breeding health guarantee are achieved. Originally possibly discarded ox gall powder residues are converted into effective raw materials after being treated, the breeding cost is reduced, meanwhile, waste discharge is reduced, and the method is suitable for practical application of farmers.

The invention discloses a preparation method of a core-shell type hydrogel microsphere wrapping xanthogenic bacteria and production application of the core-shell type hydrogel microsphere in cultivation of calculus bovis in a cattle body. The preparation method specifically comprises the following steps: S1, preparing an external phase solution; S2, preparing a shell solution; S3, preparing a core solution; according to the application, the specially-made core-shell hydrogel microspheres are implanted through minimally invasive surgery, the microspheres can realize long-term efficient colonization of yellow bacteria so as to improve the bilirubin conversion efficiency, and also can specifically adsorb key enzymes and bilirubin particles, so that the yellowing period is remarkably shortened, and meanwhile, the high success rate and the high quality of calculus bovis are guaranteed.

The invention relates to the technical field of calculus bovis factitius detection equipment, and discloses an online detection device for producing calculus bovis factitius, which comprises an equipment rack, the hardness detection part, the picture acquisition part, the rolling powder preparation part, the rotary drum mechanism, the material loading mechanism and the stock bin driving tool are integrated on the equipment rack and are sequentially matched to realize online detection and pretreatment of the calculus bovis factitius, and the rotary drum mechanism is used as a core transmission part to drive the material loading mechanism to do uniform-speed circular motion, so that the material loading mechanism can perform uniform-speed circular motion according to a preset working procedure; the hardness detection part and the picture acquisition part are sequentially and precisely used for completing dual detection, then the rolling powder-making part is used for completing material pretreatment, manual intervention is not needed for material transfer in the whole process, tedious operation of traditional manual detection is thoroughly replaced, the labor intensity of operators is effectively reduced, and the working efficiency is improved. The defects that in the prior art, detection equipment and pretreatment equipment are mutually independent, connection is tedious, transfer time is long, and efficiency is low are overcome.

The present invention provides the use of a traditional Chinese medicine composition in the preparation of a drug for treating heart failure. The traditional Chinese medicine composition comprises the following components in parts by weight: 46-53.6 parts of nutmeg, 42.4-49.2 parts of radix vladimiriae, 98.4-111.6 parts of fructus chebulae, 50.8-65.2 parts of stigma croci, 17.2-26 parts of calculus bovis and 9.2-13.6 parts of bear gall powder. By means of ingenious combination of a plurality of traditional Chinese medicine components, the traditional Chinese medicine composition has enhanced drug efficacy and an expanded treatment range, can regulate qi and blood as well as yin and yang and treat internal organs, and can effectively treat heart failure.

Disclosed are a traditional Chinese medicine composition for clearing heat, detoxifying, relieving sore throat, and reducing swelling, and a preparation method therefor, and use thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 10-20 parts of Houttuyniae Herba, 8-15 parts of Astragali Radix, 8-15 parts of Andrographis Herba, 8-15 parts of Scrophulariae Radix, 8-15 parts of Platycodonis Radix, 8-15 parts of Archidendri Folium, 2-6 parts of Lonicerae Japonicae Flos, 2-6 parts of Bupleuri Radix, 2-6 parts of Belamcandae Rhizoma, 2-6 parts of Peucedani Radix, 1-4 parts of Trollii Flos, and 0.1-0.6 parts of Calculus Bovis Factitius. The effect of the traditional Chinese medicine composition in treating acute pharyngitis and fever abatement is superior to that of each comparative example.