49 results about "Calculus bovis" patented technology

The invention discloses a preparation method and application of a Tibetan medicine Qipeng pill. The Qipeng pill comprises Tibetan medicine active components and microcrystalline fibers, the microcrystalline fibers account for 30% of the weight of pellets, and the method comprises the following steps: uniformly mixing the active components and the microcrystalline fibers to obtain a mixture, adding 75% ethanol to prepare a soft material, filling the soft material into an extruder, extruding the soft material into strip columns, cutting the strip columns in a rolling machine, rolling the strip columns into pellets with uniform sizes, drying and sieving to obtain the Qipeng pill. Wherein the active component is prepared from fine powder of seven raw materials including fructus chebulae (denucleated), radix aconiti lateralis preparata, radix aucklandiae, rhizoma acori calami, Muslim myrrh, calculus bovis factitius and artificial musk. The Qipeng pill prepared by the method is good in roundness, good in friability, high in yield and uniform in size. In addition, the Qipeng pill also has the prospect of treating acute lung injury.

The invention relates to the technical field of traditional Chinese veterinary medicines, in particular to a veterinary antiviral traditional Chinese medicine composition and a preparation method thereof.The traditional Chinese medicine composition is prepared from, by weight, 20-40 parts of gypsum and 15-30 parts of rhizoma anemarrhenae; 15-30 parts of cornu bubali; 10-15 parts of manyleaf paris rhizome; 10-15 parts of radix paeoniae rubra; 10 to 15 parts of moutan bark; 10 to 15 parts of uncaria rhynchophylla; 0.3-1 part of calculus bovis factitius; 15 to 30 parts of magnet; 1-3 parts of benzoin; 10-15 parts of radix trichosanthis; and 10-15 parts of cape jasmine. The preparation method comprises the following steps: decocting the traditional Chinese medicines to prepare traditional Chinese medicine decoction, and concentrating overnight filtrate under reduced pressure to obtain traditional Chinese medicine fluid extract; and adding clinically acceptable auxiliary materials into the traditional Chinese medicine fluid extract, and preparing a clinically acceptable oral traditional Chinese medicine preparation by adopting a conventional preparation mode. The veterinary antiviral traditional Chinese medicine composition provided by the invention has a good treatment effect on viral diseases of livestock according to the principle of dialectical treatment of traditional Chinese veterinary medicines, can be used for replacing western medicines, and effectively avoids the problems of food safety and drug resistance caused by drug residues of the western medicines.

The invention belongs to the technical field of in-vitro cultured calculus bovis, and provides in-vitro cultured calculus bovis and a preparation method thereof. The preparation method comprises the following steps: (1) separating cells; (2) primary culture; (3) cell inoculation and cultivation: adding the serum-free culture medium into the carrier matrix, putting the carrier matrix into a reactor, and performing cell inoculation on the carrier matrix after passage; the inoculated culture comprises a proliferation period; a synthesis period; a crystallization period; and (4) collecting and purifying the calculus bovis, namely stopping culturing after 45 days, and sequentially collecting, cleaning, degreasing, drying and crushing the calculus bovis. The preparation method aims at solving the problems of long culture period, unstable content of effective components, high production cost, large batch difference and the like in the existing in-vitro calculus bovis culture technology by optimizing a culture medium formula, regulating and controlling a culture process and a purification process.

The invention belongs to the technical field of traditional Chinese medicine (Tibetan medicine), and particularly relates to a Tibetan medicine composition for treating new coronavirus infection and application of the Tibetan medicine composition. The invention discloses a Tibetan medicine composition for treating new coronavirus infection and application of the Tibetan medicine composition. The composition is prepared from the following components in parts by weight: 100 to 700 parts of fructus chebulae, 10 to 80 parts of radix aconiti lateralis, 10 to 60 parts of radix aucklandiae, 50 to 600 parts of rhizoma acori calami, 10 to 50 parts of Muslim myrrh, 0.01 to 50 parts of calculus bovis factitius and 0.01 to 50 parts of artificial musk. The composition can inhibit the mRNA expression of the N gene and the ORF1ab gene after the SARS-CoV-2 virus infects the Vero cell, so that the treatment on the novel coronavirus infection is realized.

The invention discloses an application of a traditional Chinese medicine composition in preparation of a medicine for preventing and treating chronic heart failure with cognitive impairment. The traditional Chinese medicine composition comprises the following components: ginseng, lucid ganoderma, safflower, musk, calculus bovis, bear gall, pearl, venenum bufonis, radix aconiti carmichaeli and borneol. The traditional Chinese medicine composition has a good treatment effect on qi deficiency and blood stasis type chronic heart failure accompanied with cognitive impairment, and a large number of test data prove that the traditional Chinese medicine composition can effectively improve the heart function, and / or cognitive function and / or traditional Chinese medicine symptoms of qi deficiency and blood stasis type chronic heart failure accompanied with cognitive impairment through reasonable compatibility of all the components, so that the traditional Chinese medicine composition has a good curative effect on qi deficiency and blood stasis type chronic heart failure accompanied with cognitive impairment. The symptoms of chronic heart failure with cognitive impairment are relieved from multiple aspects, and the progress of the disease course is blocked. The prescription is safe and reliable without toxic and side effects on human bodies.

The invention provides a high-fidelity calculus bovis and a preparation method thereof, and belongs to the technical field of traditional Chinese medicines. According to the technical scheme provided by the invention, the high-fidelity calculus bovis is accurately prepared by taking the mean value of the contents of various components of the natural calculus bovis as a reference and accurately measuring the contents of various components in the raw materials, fully utilizing the original components of the ox bile or ox gall powder, not adding other non-calculus bovis components and combining the existence forms of the components. The problems that existing artificial calculus bovis is greatly different from natural calculus bovis in efficacy, and toxic and side effects are relatively high are solved. The shape, the forming process and the components of the product are highly similar to those of natural calculus bovis; the medicine effect of the calculus bovis is improved, and the production cost is reduced.

The invention discloses a traditional Chinese medicine manufacturing knowledge extraction method and device based on a small-sample fine-tuning large language model and prompt engineering and electronic equipment. The method comprises the following steps: firstly, acquiring low-quality non-standard real text data in the field of manufacturing of the same-kernel calculus bovis heart-clearing pills, and generating a high-quality standard text by utilizing a large language model to construct a mixed evaluation set; then, a few-sample training set is constructed through human-in-loop mechanism iteration, fine adjustment is carried out on a GPT-4omini model through OpenAI API, and fine adjustment parameters comprise the learning rate 1e-4, the batch size 5 and the training round number 5; meanwhile, a structured prompt template for clearly specifying entity types and relationships is constructed; and after model reasoning, automatically outputting a structured result in a JSON-LD format, analyzing the structured result, and storing the analyzed structured result in a Neo4j graph database to construct a knowledge graph. According to the method, through combination of few-sample fine adjustment and prompt engineering, the sensitivity to data quality is remarkably reduced, and the knowledge extraction problem of non-standard texts with professional term nesting and structure breakage in the field of traditional Chinese medicine manufacturing is effectively solved.

The invention belongs to the technical field of biochemical pharmacy, and particularly relates to a compound bezoar composition, decoction piece type compound bezoar and a preparation method of the decoction piece type compound bezoar. The compound calculus bovis composition provided by the invention comprises 94-96% by mass of main agents and 8 kinds of calculus bovis intermediates, the mass content of the auxiliary agent is 4-6%, and the auxiliary agent is six commercially available finished product combined cholic acid. The bilirubin content of the bezoar intermediate used in the invention is increased by more than 30% and the yield is increased by more than 25% compared with the existing biochemical reaction process of oxgall. The DPPH free radical scavenging rate of the compound bezoar composition reaches 89.6% + / -2.1% and is increased by 25.7-36.9% compared with 58.3% + / -3.5% of a product prepared from ox bile, and through t inspection, p is smaller than 0.01 (n is equal to 5). Free cholic acid intervention is strictly prohibited, lithocholic acid addition is completely eradicated, and the composition has the advantages of being high in bilirubin content, high in oxidation resistance and high in biological activity and adapts to the physiological characteristics of the human body.

The invention discloses a traditional Chinese medicine composition for inhibiting and fading scar hyperplasia and a preparation method of the traditional Chinese medicine composition, and belongs to the field of traditional Chinese medicine compositions for fading scars. 5 to 15 parts of a gel matrix; 10 to 25 parts of an oil phase component; 3-8 parts of an emulsifier and a thickener; and the balance of water. Wherein the active traditional Chinese medicine component consists of 1-5 parts of calculus bovis factitius, 1-3 parts of artificial musk, 3-10 parts of cowherb seed, 3-10 parts of golden cypress, 2-8 parts of frankincense and 2-8 parts of myrrh. The traditional Chinese medicine composition for inhibiting and fading scar hyperplasia and the preparation method of the traditional Chinese medicine composition have the beneficial effects that the traditional Chinese medicine composition for inhibiting and fading scar hyperplasia and the preparation method of the traditional Chinese medicine composition are provided, all the medicines are combined to jointly achieve the effects of promoting blood circulation to remove blood stasis, dredging collaterals, removing stasis, resisting inflammation and promoting tissue regeneration and directly refer to the pathogenesis core of scar hyperplasia, and an oil-in-water (O / W) latex dosage form is adopted, so that the traditional Chinese medicine composition has the refreshing effect of gel and the moistening effect of cream, and is easy to coat and good in air permeability.

The invention discloses a bezoar quality improving method based on natural pasture environment optimization. According to the method, the internal quality of the calculus bovis is remarkably improved through multi-dimensional cooperative regulation and control. A natural feed basis with balanced nutrition is provided for cattle from soil environment baseline investigation to precise pasture proportioning, and by combining directional cultivation and implantation of genetic engineering strains, the metabolic activity of rumen microorganisms is effectively enhanced, and accumulation of key components for synthesis of calculus bovis is promoted. The linkage application of the intelligent monitoring system and the environment regulation and control device optimizes the living environment of cattle in real time, and cooperates with innovative intervention means such as lavender essential oil and music therapy, so that the stress reaction of cattle herds is remarkably reduced, and the efficient operation of liver metabolic pathways is guaranteed. The directional feeding of the functional lick bricks further enhances the conversion efficiency of the calculus bovis precursor substance, the whole-process data tracing ensures the controllability of the quality formation process, and finally the improvement of the content of effective active ingredients in the calculus bovis and the enhancement of the quality stability are realized.

The invention belongs to the technical field of microorganisms, and particularly relates to a bacterial strain for promoting formation of calculus bovis, a microbial agent and application of the bacterial strain, the bacterial strain is classified and named as Escherichia fergusonii, the bacterial strain is preserved in China General Microbiological Culture Collection Center on May 13, 2025, and the preservation number is CGMCC No.34526. The invention further discloses a preparation method of the bacterial strain for promoting formation of calculus bovis. The strain can be used as a transformation strain for in-vitro cultivation of calculus bovis and can also be used as an implantation strain for artificial in-vivo cultivation of calculus bovis, and the problems that in the process of artificial in-vitro cultivation or in-vivo cultivation of calculus bovis, thalli are low in bile tolerance and enzyme production activity, short in survival time in ox bile and low in calculus bovis forming efficiency are solved.

The invention discloses eye protection liquid and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine external preparations. The eye protection liquid is prepared from a chrysanthemum extract, borneol, calculus bovis factitius, venenum bufonis, realgar, a mint extract, a pipewort extract, a feather cockscomb seed extract, a butterflybush flower extract, pearl powder and purified water according to a specific weight part ratio, and is prepared by soaking, distilling, filtering and filling. The traditional Chinese medicine composition can rapidly permeate into eyes and directly enter focus, can relieve and treat various eye diseases such as presbyopia, myopia, amblyopia, cataract and the like, has the effects of soothing liver and relieving depression, promoting blood circulation and dredging collaterals, tonifying kidney and nourishing yin, supplementing optic nerve nutrition and improving microcirculation around the eyes, has the total effective rate of 100% and the cure rate of 80-95%, and is free of side effects and drug resistance and convenient to use.

The utility model relates to the field of injectors, in particular to a bezoar strain injector with a leakage-proof design. Comprising a needle cylinder, a piston is installed on the inner wall of the needle cylinder, a needle head is installed at one end of the needle cylinder, an adjusting structure is arranged on one side of the piston and comprises a connecting block, the connecting block is fixedly connected with the piston, a connecting plate is fixedly connected to one side of the connecting block, and a sliding groove is formed in the upper surface of the connecting plate; a positioning block is slidably connected to the inner wall of the sliding groove, a fixing hole is formed in the upper surface of the positioning block, a fixing rod is slidably connected to the inner wall of the connecting plate, and a limiting plate is fixedly connected to one end of the fixing rod. The calculus bovis strain injector with the leakage-proof design has the advantages that the position of the piston can be effectively locked, the piston is prevented from moving due to external factors in the operation, transportation or storage process, the safety of strains is ensured, and the leakage phenomenon is avoided.

The invention relates to a method for detecting the content of arsenic in quick-acting calculus bovis pills and application thereof, and belongs to the technical field of traditional Chinese medicine detection. The invention provides a method for detecting the content of arsenic in quick-acting bezoar pills, which comprises the following steps: mixing the quick-acting bezoar pills, nitric acid and hydrochloric acid, digesting, and adding water to a constant volume to obtain a diluent; mixing the acid solution and the diluent to obtain a sample solution; and measuring the absorbance of the sample solution by adopting an atomic absorption spectrophotometric method, and calculating the content of arsenic in the quick-acting calculus bovis pill according to the standard curve. The detection method provided by the invention can accurately detect the content of arsenic in the quick-acting calculus bovis pill, and has the characteristics of high specificity, repeatability, stability and accuracy.

The invention discloses a composition for relieving chronic pain related depressive mood. The composition is mainly prepared from the following traditional Chinese medicinal materials in parts by weight: 5-30 parts of borneol, 5-30 parts of musk, 50-100 parts of liquorice, 50-100 parts of burdock, 50-100 parts of gardenia kernel, 20-60 parts of calculus bovis, 50-100 parts of acorus gramineus and 50-100 parts of radix curcumae. Molecular mechanisms and potential treatment effects of borneol powder for treating chronic pain related depressive mood are researched by a modern scientific method, and safety and effectiveness of medicines are evaluated by pharmacodynamic and toxicological evaluation and animal experiments, so that the traditional Chinese medicine composition capable of effectively relieving chronic pain related depressive mood is provided.

The invention discloses a compound paracetamol and amantadine hydrochloride capsule containing caffeine microcapsules, which relates to the technical field of medicines and comprises paracetamol, amantadine hydrochloride, calculus bovis factitius, pharmaceutic adjuvants and functional microcapsule units. The functional microcapsule unit has a three-layer structure: a core material taking caffeine and microcrystalline cellulose as a core, an ethyl cellulose controlled release layer and a quick release layer containing chlorpheniramine maleate. According to the structure, time sequence controlled release of drugs is achieved by synthesizing a polymer coating material, chlorpheniramine maleate is quickly released when encountering gastrointestinal fluid to quickly resist allergy, and caffeine starts to be slowly released after being effectively delayed to the intestinal environment, so that the time when the plasma concentration reaches the peak tends to be synchronous with the time when chlorpheniramine maleate reaches the peak; the drowsiness side effect can be effectively resisted.

The novel fixing frame comprises a bottom plate and side plates, the side plates are arranged on the left side and the right side of the bottom plate in a welded mode, the side plates are provided with handrails and second door plates, the handrails are arranged above the second door plates, hollow grooves are formed between the second door plates and the handrails, and the second door plates are arranged in the hollow grooves. The side plates are provided with limiting mechanisms matched with the hollowed-out grooves. The limiting mechanism comprises a sliding rail, a sliding block and a steel pipe, the sliding block is arranged on the sliding rail in a sliding mode, a clamp is welded to the sliding block, and the steel pipe penetrates through the clamp and the hollowed-out groove. The novel fixing frame for artificial cultivation of calculus bovis is simple in structure, practical in function and ingenious in design, and effectively solves the problem that an existing fixing frame is not provided with a side face door plate for an operation, and inconvenience is brought to the operation process.

A method for screening and efficiently cultivating bezoar strains belongs to the field of bezoar strain screening, and comprises the following steps: step 1, inoculating a culture medium with low-pathogenicity Escherichia coli for culturing, comparing and observing, picking out single colonies with good growth vigor for subculture, and preserving the strains after culture; 2, taking the primarily screened preserved strain, reviving in four regions of an LB solid culture medium by marking lines, selecting a single colony, putting the single colony into a first gradient liquid bile culture medium, culturing, measuring OD600, and if OD600gt is detected, determining that the single colony is not detected; and 0.6, the strain can be placed in a liquid bile culture medium of the next gradient, and the strain which can grow in the three gradients can be inoculated into fresh oxgall for culture. The method has the advantages that the escherichia coli strain with high beta-glucuronidase activity for efficiently cultivating calculus bovis can be obtained, in-vitro cultivation verifies that the escherichia coli strain has bile resistance, calculus bovis analogues can be obtained, and the physicochemical properties of the calculus bovis analogues are similar to those of natural calculus bovis.

The disclosure relates to a traditional Chinese medicine composition, comprising active ingredients derived from Cornu caprae or Cornu saigae tataricae, Radix scutellariae, Bulbus fritillariae ussuriensis, Radix glycyrrhizae, Radix et rhizoma rhei, Gypsum fibrosum, Calculus bovis artifactus and Lapis Chloriti, the said active ingredients comprise in parts by weight: at least 1600 parts of amino acids; at least 120 parts of gallic acid; at least 130 parts of liquiritin; at least 20 parts of liquiritigenin; at least 400 parts of baicalin; at least 40 parts of oroxyloside; at least 120 parts of wogonoside; at least 280 parts of glycyrrhizic acid; at least 12 parts of chrysin-7-O-β-D-glucoronic acid; at least 50 parts of aloe-emodin-8-O-β-D-glucopyranoside; at least 30 parts of chrysophanol-1-O-β-D-glucopyranoside; at least 45 parts of chrysophanol-8-O-β-D-glucopyranoside; at least 260 parts of hyodeoxycholic acid; at least 150 parts of cholic acid. The traditional Chinese medicine composition in the present invention possess antipyretic, anti-inflammatory and antitussive effects.

The invention relates to a preparation method for producing calculus bovis by a chemical fermentation technology, which is characterized in that animal bile such as cattle (pigs, sheep and poultry) is used as a raw material, and the calculus bovis is produced by a modern process technology. The composition is prepared from the following components in parts by weight: 8 to 15 parts of taurine, 13 to 26 parts of ox gall powder, 1 to 12 parts of cholic acid, 1 to 17 parts of zinc sulfate, 1 to 15 parts of bilirubin, 20 to 40 parts of calcium gluconate, 20 to 38 parts of deoxycholic acid, 1 to 16 parts of cholesterol, 0.1 to 4.5 parts of fatty acid, 0.05 to 0.95 part of amylase and 0.05 to 2.22 parts of honeysuckle flower extract.

The invention relates to the technical field of sustained-release veterinary preparations, in particular to a heat-clearing and detoxifying sustained-release Niuchan preparation and a preparation method thereof. The sustained-release Niuchan preparation capable of clearing away heat and toxic materials comprises the following raw materials in parts by mass: 1-3 parts of venenum bufonis, 3-6 parts of calculus bovis factitius, 1-5 parts of a Chinese herbal medicine extract, 1-5 parts of beta-cyclodextrin, 90-100 parts of dextrin, 700-800 parts of cane sugar and 1-3 parts of a borneol ethanol solution. The Chinese herbal medicine extract is prepared by the following steps: adding scutellaria baicalensis and liquorice into water, vacuumizing to-0.04 to-0.06 MPa, keeping for 5-10 minutes, performing reflux boiling at 60-80 DEG C for 2-6 hours, and filtering to obtain an extracting solution a and filter residues a; adding an ethanol water solution into the filter residue a, carrying out reflux extraction at 60-70 DEG C for 1-3 hours, and filtering to obtain an extracting solution b; combining the extracting solution a and the extracting solution b, then adding dendritic polylysine, stirring for 1-2 hours at 40-50 DEG C under the protection of nitrogen, carrying out homogenizing cycle treatment for 2-4 times, and concentrating.

The invention provides a traditional Chinese medicine composition for treating throat diseases, and relates to the field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 0.15 to 0.3 part of borneol, 1.5 to 3 parts of refined borax, 0.3 to 1 part of nacre mother of pearl, 3 to 9 parts of bulbus fritillariae cirrhosae, 0.03 to 0.01 part of musk and 0.15 to 0.3 part of calculus bovis. The composition has the effects of clearing heat and relieving sore throat, reducing swelling and removing stasis, stopping bleeding and activating blood, discharging phlegm blockage, dredging and benefiting viscera, opening yin and benefiting skills, relieving pain and drawing out phlegm and poison, is used for wounds after throat minimally invasive surgery, and is beneficial to rapid recovery of the wounds.

The invention belongs to the technical field of traditional Chinese medicine authenticity identification and quality control, and particularly relates to an artificial intelligence calculus bovis trace element quality attribute rapid detection and discrimination method and device and electronic equipment. The method comprises the following steps: firstly, quickly and nondestructively acquiring calculus bovis comprehensive element fingerprint spectrum data by adopting a high-sensitivity X-ray fluorescence spectrum, and constructing a calculus bovis database; secondly, evaluating the quality consistency of the calculus bovis according to the similarity coefficient; and finally, establishing a back propagation neural network and a multi-layer sensor model, and realizing rapid and accurate discrimination of the natural product and the artificial product of the calculus bovis. Compared with a traditional method, the method has the advantages of rapidness, no damage, low cost and high accuracy, and is suitable for quality monitoring and market supervision of traditional Chinese medicinal materials.

The invention discloses a formula for treating tumors and a preparation process, relates to the technical field of medicaments, and researches and develops a medicine which is safe and effective, can play a better role in treating middle and advanced stage tumors and has a treatment effect on related diseases. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 10 to 30 parts of dried toad skin, 15 to 35 parts of radix fici simplicissimae, 5 to 20 parts of radix astragali seu hedysari essence, 3 to 15 parts of radix ginseng, 1 to 5 parts of in-vitro cultured calculus bovis, 0.1 to 1 part of artificial musk, 5 to 15 parts of vinegar frankincense and 5 to 15 parts of vinegar myrrh. The formula disclosed by the invention has the effects of detoxifying, diminishing swelling and relieving pain. The traditional Chinese medicine is used for treating middle and advanced tumors, chronic hepatitis B and the like; and the traditional Chinese medicine composition can be used for treating ulcer, furunculosis, scrofula, abscess and cancerous swelling caused by heat toxin accumulation.

The utility model relates to the field of trays for selecting calculus bovis, in particular to a tray for selecting calculus bovis. Comprising a placing disc, an auxiliary structure is arranged on the inner wall of the placing disc, the auxiliary structure comprises two sliding grooves, the two sliding grooves are formed in the inner wall of the placing disc, a connecting groove is formed in one end of the placing disc, sliding blocks are slidably connected to the inner walls of the sliding grooves, and magnetic sheets are fixedly connected to the bottom walls of the sliding grooves. And iron sheets are fixedly connected to the ends, close to the magnetic sheets, of the sliding blocks, placing plates are fixedly connected to the sides, close to each other, of the two sliding blocks, notches are formed in the inner walls of the placing plates, and moving blocks are fixedly connected to the two sides of the ends, close to the connecting grooves, of the placing plates. The material tray for selecting the calculus bovis has the advantages that the special container is designed, cattle gastric juice can be independently contained, the direct contact between the cattle gastric juice and the material tray is avoided, the material tray is prevented from being eroded by the cattle gastric juice, and the long service life of the material tray and an electronic scale is ensured.

The invention discloses a traditional Chinese medicine composition for treating hyperlipemia as well as a preparation method and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from the following raw materials in parts by mass: 5-15 parts of calculus bovis, 5-15 parts of raw rhubarb, 10-30 parts of pseudo-ginseng, 5-15 parts of leech and 5-15 parts of American ginseng. The traditional Chinese medicine composition disclosed by the invention has the characteristics of simple medicine flavor, special medicine effect and rigorous compatibility, and compared with a traditional blood fat reducing formula consisting of multiple traditional Chinese medicines, unnecessary medicine combination is avoided, so that potential toxicity and adverse reaction risks are reduced, the safety of medication is improved, and the traditional Chinese medicine composition is suitable for long-term use. Besides, the whole prescription is ingenious in design, not only is fundamental treatment of diseases considered, but also comprehensive conditioning of body functions is considered, the content of blood lipid metabolism related indexes including total cholesterol (TC), triglyceride (TG) and low-density lipoprotein cholesterol (LDL-C) can be remarkably reduced, and a definite treatment effect on hyperlipidemia is achieved.

The invention provides a traditional Chinese medicine composition for treating diabetes and / or diabetic complications, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition comprises calculus bovis factitius, rhizoma atractylodis, almond, radix paeoniae rubra, ligusticum wallichii, salvia miltiorrhiza, semen momordicae, elecampane, ginseng, penis et testis cervi, hippocampus, syngnathus, eucommia ulmoides, fructus psoraleae, notopterygium root, radix clematidis, sculellaria barbata, semen cassiae, curcuma zedoary, rhizoma sparganii, radix trichosanthis, felwort and astragalus membranaceus. The traditional Chinese medicine composition has the effects of promoting the production of body fluid to quench thirst, clearing away heat and toxic materials and invigorating spleen to eliminate dampness through the synergistic effect of the medicines, has a good treatment effect on type I diabetes mellitus, type II diabetes mellitus and diabetic complications (lactic acidosis, ketoacidosis and symmetric distal polyneuritis caused by ketoacidosis), has a clinical total effective rate of 91.88%, does not have toxic or side effects, and is suitable for clinical application. The preparation method is simple, and the use is convenient.

The utility model relates to the technical field of bezoar forming induction, and discloses a bezoar forming induction device which comprises a first body and a second body, the outer side of the surface of the bottom end of the first body is fixedly sleeved with a first connecting mechanism, and the top of the second body is provided with a second connecting mechanism. Movable limiting mechanisms are movably clamped to the outer sides of the surfaces of the second connecting mechanism and the first connecting mechanism, each of the first connecting mechanism and the second connecting mechanism comprises an annular frame, and a fixing groove is formed in the side, close to the first body or the second body, of each annular frame; through mutual cooperation of the first connecting mechanism, the second connecting mechanism and the movable limiting mechanism, the first body and the second body can be stably connected, and otherwise, the first body and the second body can be quickly separated; the adsorption balls can be conveniently implanted into the inner sides of the first body and the second body, and the operation is convenient.

Provided is a compound hydrocortisone and neomycin sulfate granule, including the following components in parts by mass: 140 parts of acetaminophen, 1 part of chlorpheniramine maleate, 1.2 parts of methylephedrine hydrochloride, 2 to 2.5 parts of an inclusion stabilizer, 3.0 parts of artificial calculus bovis, and 0.5 to 1 parts of a caramel. In a method for preparing the compound hydrocortisone and neomycin sulfate granule, natural Chinese medicinal herbs are subjected to extraction to obtain natural stabilizers for stabilizing low-concentration acetaminophen and chlorpheniramine maleate, and the natural stabilizers are encapsulated with hydroxypropyl-β-cyclodextrin with a specific degree of substitution (DS).

Provided is a method for identifying Calculus Bovis and a substitute thereof, and use thereof. The method includes the following steps: subjecting a cholic acid (CA) component of the Calculus Bovis and the substitute thereof to qualitative and quantitative analysis by ultra-performance liquid chromatography-mixed quadrupole orbitrap mass spectrometry (UPLC-Q-orbitrap-MS), and then establishing a chromatogram of the CA component of the Calculus Bovis and the substitute thereof; screening a significantly different CA component in the Calculus Bovis and the substitute thereof by multivariate statistical analysis (MVSA); and establishing a discriminant function equation for the Calculus Bovis and the substitute thereof to identify the Calculus Bovis and the substitute thereof. The method provides a novel and simple evaluation standard for a quality control of Chinese patent medicines, and a reference for the construction of a quality control system of Chinese medicine compound prescriptions.