337 results about "Precursor substance" patented technology

A process for easily synthesizing a zeolite substance containing an element having a large ionic radius in the framework at a high ratio. This process comprises the following first to fourth steps: First Step: a step of heating a mixture containing a template compound, a compound containing a Group 13 element of the periodic table, a silicon-containing compound and water to obtain a precursor (A); Second Step: a step of acid-treating the precursor (A) obtained in the first step; Third Step: a step of heating the acid-treated precursor (A) obtained in the second step together with a mixture containing a template compound and water to obtain a precursor (B); and Fourth Step: a step of calcining the precursor (B) obtained in the third step to obtain a zeolite substance.

A technique for atomic layer deposition is disclosed. In one particular exemplary embodiment, the technique may be realized by an apparatus for atomic layer deposition. The apparatus may comprise a process chamber having a substrate platform to hold at least one substrate. The apparatus may also comprise a supply of a precursor substance, wherein the precursor substance comprises atoms of at least one first species and atoms of at least one second species, and wherein the supply provides the precursor substance to saturate a surface of the at least one substrate. The apparatus may further comprise a plasma source of metastable atoms of at least one third species, wherein the metabstable atoms are capable of desorbing the atoms of the at least one second species from the saturated surface of the at least one substrate to form one or more atomic layers of the at least one first species.

The invention discloses a dentiform sphere shaped heavy oil hydrotreated catalyst and a preparation method thereof. The catalyst comprises an active composition, an addition agent and a dentiform sphere shaped aluminum oxide carrier, wherein the active composition comprises compounds of cobalt and nickel, and a compound of molybdenum or/and tungsten; the addition agent comprises a compound of phosphor, silicon, boron or halogen or compounds of any two compositions of the phosphor, the silicon, the boron and the halogen; and compositions according to gross weight of the dentiform sphere shaped heavy oil hydrotreated catalyst comprise: 2 to 6 percent of the cobalt compound, 3 to 10 percent of the nickel compound, 0 to 26 percent of the molybdenum compound, 0 to 8 percent of the tungsten compound, and 0.5 to 2 percent of the addition agent. The catalyst has the characteristics of high specific surface area, large pore volume, high strength, proper surface acid content, small bed pressure drop, low reaction temperature and high activity of hydrodesulfurization and denitrification. The preparation method comprises preparation of a precursor substance of the aluminum oxide carrier, preparation of the dentiform sphere shaped aluminum oxide carrier, preparation of a catalyst steeping fluid and preparation of the catalyst. The preparation process can be mastered and realized simply and easily.

The invention relates to a method for conversion of low-hydrogen heavy oil to light fractions by hydrogenation with hydrogen-supplying hydrocarbons, which is a process for conversion of heavy oil such as coal pitch by hydrogenation with hydrogen-supplying hydrocarbon stream enriched in hydrogen-supplying hydrocarbons. The method has the effects of inhibiting condensation coking speed, increasing liquid product yield in the process of conversion of coal tar heavy oil to light fractions, improving product quality, reducing reaction temperature increase and enhancing stability and safety of device operation. The hydrogen-supplying hydrocarbon stream can be hydrogenation reaction effluents in partial hydrogenation saturation process of bicyclic aromatic hydrocarbons or polycyclic aromatic hydrocarbons or oil products enriched in partial saturated aromatic hydrocarbons obtained in the separation process of bicyclic aromatic hydrocarbons or polycyclic aromatic hydrocarbons. The precursor substance of hydrogen-supplying solvent oil is coal tar fractions with boiling points of 350-450 DEG C, and the hydrogen-supplying solvent oil mainly comprises hydrocarbon components with ordinary boiling points of 350-450 DEG C. The combination of the method for conversion of coal tar heavy oil to light fractions by hydrogenation and method for conversion of coal tar light fractions by hydrogenation constitutes a novel combined process for conversion of full-range fractions of coal tar by hydrogenation.

The invention discloses a method for mensurating the aroma quality of tobacco and a tobacco product. The method comprises the following steps: firstly, through an approach for producing an aroma substance or a degradation rule of a precursor substance, total or partial substances are selected from basic aroma substances as representative characteristic substances; secondly, an aroma-causing composition in tobacco leaf is mensurated and analyzed by simultaneously adopting a distillation and extraction-gas chromatography/mass spectrometry method; and finally, a response factor of the substances to the instrument obtained through analysis and detection is set as 1; a calculation factor KR value of a sample is calculated through directly applying data obtained by the instrument; and the aroma quality of the sampler is intuitively characterized. The method provides a convenient and effective mensuration method for controlling tobacco quality.

The invention discloses a quinoline compound, and a preparation method, an intermediate, a medicinal composition and an application thereof/ The invention provides a quinoline compound represented by formula 1 shown in the specification, and its pharmaceutically acceptable salts, solvates, metabolites, metabolism precursors or medicinal precursors. The quinoline compound has a good inhibition effect on tyrosine kinases C-Met, and can be used for preparing medicines for prevention, treatment or adjuvant treatment of many C-Met expression or activity related diseases, especially tumor diseases.

The invention relates to a ready-to-use aerogel microsphere, which uses an aerogel microsphere as a core, is coated or doped with a functional material or a functional group on the surface, and contains at least a functional material or functional group and at least an aerogel. The invention further discloses a method for producing the ready-to-use aerogel microsphere, and uses of the ready-to-useaerogel microsphere, wherein the method comprises: carrying out homogenizing or on starting aerogel particles or an aerogel preparation precursor substance by using an ultrahigh pressure jet device,or carrying out magnetic grinding or carrying out homogenizing and magnetic grinding, doping or coating with a photosensitive material/photocurable material, a functional material or a functional monomer substance or a combination thereof, and finally carrying out three-spectrum photocuring to obtain the ready-to-use aerogel microsphere material.

The invention discloses an amphiphilic prodrug of 7- ethyl-10-hydroxycamptothecin, which is prepared by connecting hydroxyl at the site 10 and/or 20 site of the 7-ethyl-10- hydroxycamptothecin and a hydrophilic group through a scissionable chemical bond. The amphiphilic prodrug is self-assembled in water to form a micelle or vesicle structure. Therefore, on one hand, the solubility of SN-38 in water is greatly increased, and the stability of SN-38 lactone rings is improved; and on the other hand, the drug loading rate is high and the SN-38 can be quickly released in cells, consequently the defect of low drug loading rate of traditional drugs is overcame. Moreover, with the nano-micelles or the nano-vesicles of the prodrug, EPR (enhanced permeability and retention) effect targeted cancer tissues of tumors can be effectively utilized.

The invention discloses a vitamin K2 and preparation process thereof. According to the process, 1-hydroxyl-2-naphthoic acid resistant flavobacterium strain HNA12-D is fermented and cultured, and vitamin K2 efficiently metabolizes in the strain through the batch feeding of glycerin serving as the carbon source, peptone serving as the nitrogen source and precursor substances, and is extracted by using organic solvents and separated by macroporous resin, and the yield and purity of the product are improved. The total output of the vitamin K2 crude product is 200-600 mg/L after the flavobacterium strain HNA12-D of the invention is fermented and cultured for 120-144 hours, and the product purity reaches 80-99 percent after absorption chromatography; compared with the prior art, the yield output and the product purity are greatly improved, and the product can be used in industrial production.

The invention provides a method for directly synthesizing M-phase vanadium dioxide nano particles by a liquid phase method. The method comprises the following steps of: dissolving one or a mixture of vanadium pentoxide and metavanadate, which is taken as a raw material in water, heating under normal pressure with stirring, slowly dripping a reducing agent, and reacting at constant temperature to obtain precursor substance; and centrifuging and precipitating the precursor substance, mixing with distilled water, transferring into a reaction steel kettle with a teflon lining, and controlling phase purity and the particle size of a product by controlling reaction temperature, reaction time, reaction kettle filling rate, substance concentration and the like to obtain black blue M-phase vanadium dioxide nano particles. The preparation process is performed under the condition of liquid phase, a solid-phase high-temperature heating step is eliminated, and the method belongs to a low-carbon technology; and moreover, the generation condition of M-phase vanadium dioxide is mild and easy to control, and the particle size of the product is in a nano level. The method has obvious competition advantages and profit margins in the aspects of manufacturing cost, product performance, environment-friendliness and the like.

The invention relates to bifidobacterium breve CCFM1025, a fermented food and application thereof. The bifidobacterium breve CCFM1025 can be used for improving the depression-like behavior of a depression mouse, improving 5-hydroxytryptamine in the brain of the depression mouse, improving the level of 5-hydroxytryptamine and a brain-derived neurotrophic factor, reducing the level of corticosteronein serum of the depression mouse, improving the level of 5-hydroxytryptamine in the serum of the depression mouse, improving intestinal flora disturbance of the depression mouse, reducing the abundance of intestinal veillonella, improving the abundance of bifidobacterium and mycoplasmataceae, improving alpha-diversity of intestinal flora and reducing occurrence of inflammatory bowel disease and obesity. By adopting the bifidobacterium breve CCFM1025, the mRNA level of tryptophan hydroxylase in a simulated entero-chromaffin cell can be improved, the secretion volume of 5-hydroxytryptophane ofthe cell can be improved, and a precursor substance is specifically provided to synthesis of 5-hydroxytryptamine in the brain. The bifidobacterium breve CCFM1025 has a wide application prospect.

The present invention provides a catalyst precursor substance containing copper, zinc, and aluminum and exhibiting an X-ray diffraction pattern having a broad peak at a specific interplanar spacing d (Å). The present invention also provides a method for producing the catalyst precursor substance by mixing a solution containing a copper salt, a zinc salt, and an aluminum salt with a solution containing an alkali metal hydroxide or an alkaline earth metal hydroxide, thereby forming a precipitate. In the present invention, a catalyst is prepared through calcining of the catalyst precursor; the catalyst is employed for water gas shift reaction; and carbon monoxide conversion is carried out by use of the catalyst. Thus, the present invention also provides a catalyst useful for water gas shift reaction, which exhibits high activity and durability and which, even when applied to a fuel cell, can be used for a long period of time with reduction in activity being suppressed; a carbon monoxide conversion method employing the catalyst; and a fuel cell system employing hydrogen produced through the carbon monoxide conversion method.

The invention discloses a method for preparing an erythrothioneine-containing cosmetic stock solution through hericium erinaceus fermentation. The method includes the following steps of firstly, inoculating hericium erinaceus hypha into a liquid seed culture medium to be cultured to obtain seed liquid; secondly, inoculating the seed liquid into a fermentation culture medium for fermentation, and adding erythrothioneine precursor substances for fermentation to the end to obtain fermentation liquid; thirdly, processing the fermentation liquid containing mycelia to obtain an erythrothioneine-containing fermentation stock solution to serve as the erythrothioneine-containing cosmetic stock solution. The stock solution product contains erythrothioneine with the concentration of 300 mg/L or above, has the functions of high oxidization resistance, radiation prevention and inflammation resistance, and can be added as the raw material to toners, lotions, creams and milks and widely applied to the field of cosmetics.

The invention discloses a 7-ethyl-10-hydroxycamptothecine drug precursor, a preparation method and an application thereof. A structure formula of the drug precursor is represented as the formula I or II. The drug precursor is prepared through an esterification reaction between a C-10 hydroxyl group or a C-20 hydroxyl group of 7-ethyl-10-hydroxycamptothecine and a hydrophobic molecule. The drug precursor has excellent anti-tumor activity and can directly release active components in vivo in a hydrolysis manner without catalytic hydrolysis of carboxylesterase, thereby achieving a high bioavailability. The drug precursor not only has excellent solubility in water but also has great solubility in amphipathic surfactants, such as tween-80 and the like, wherein the solubility can reach more than 30 mg/ml, and a high stability is achieved even that the drug precursor is diluted in water. The drug precursor can be prepared just through a one-step esterification method, is high in yield and low in preparation cost, is high in stability and good in safety, satisfies requirements in clinical medication and in large-scale industrial production, and has excellent market prospect and clinical application value.

The invention discloses a tissue culture method of dendrobium candidum. The method comprises the following steps of: firstly culturing in dark in a seeding culture medium for a week and then transferring to be under light to culture; after performing aseptic germination for 25-35 days, transferring in a protocorm multiplication culture medium to perform multiplication culture for 25-35 days; and then sequentially performing differentiation culture in a protocorm differentiation culture medium for 40-50 days, subculture in a subculture medium for 55-65 days, strong seedling culture in a strong seedling culture medium for 55-65 days and rooting culture in a rooting culture medium for 40-50 days. A tissue culture rapid propagation method of the dendrobium candidum can be free from seasonal constraint and can realize industrialized production all the year, the environment is easy to control, and the aseptic germination rate of dendrobium candidum seeds reaches up to over 96.8 percent; and according to the method, the multiplication multiple is increased, a large number of high-grade seedlings can be rapidly bred, a precursor substance is added, and the dendrobium polysaccharide content of a dendrobium candidum test-tube plantlet is effectively accumulated.

The invention relates to a deodorized radish red pigment and a deodorization method. The deodorization method comprises the steps as follows: a radish is preheated, crushed and squeezed; pectinase is then respectively added into residues and juices to carry out enzymolysis; filter liquor is combined to obtain radish raw juices; under acid environment, chitosan with certain deacetylation degree isadded into the raw juices, odor of precursor substance glucosinolate is removed, and the purpose of deodorization is finally achieved; red pigment concentrated solution is obtained through separationand concentration, and the radish red pigment powder is obtained through carrying out spray dying for the red pigment concentrated solution. Compared with the traditional deodorization method with ion exchange, macroporous resin adsorption, acid treatment, membrane separation, and the like, the invention has simple technology and high deodorization efficiency, is green and safe, and is suitable for medium and large scale production. The prepared radish red pigment is tasteless, has natural and deep colors as well as favorable water solubility, and can be widely applied to the food and medicine field such as beverages, ciders, candies, and the like.

The invention provides a preparation method of InP quantum dots. The preparation method comprises the following steps that (a) an indium precursor is added to a non-coordinating solvent containing a first ligand to form a uniform indium-first ligand solution; (b) the indium-first ligand solution is heated to reach 180-260 DEG C, and PH3 is added to obtain a mixed system containing smaller-particle-size InP crystal nuclei; (c) the indium-first ligand solution and the PH3 are sequentially and alternatively added to the mixed system to obtain larger-particle-size InP crystal nuclei; (d) a precursor substance required by a shell layer for quantum dot synthesis is added to obtain the shell layer coated InP quantum dots. The method uses PH3 as a phosphorus source, growth of the quantum dots becomes uniform by adopting the method for alternatively adding the raw materials, and the larger-particle-size InP quantum dots are more easily to prepare.

The present invention discloses a method using Agrobacterium rhizogenes (Ar) gene to transform Rhodiola sachalinensis A.Bor to achieve a hairy root system for Salidroside production. By preparation of explant and cultivation in Ar bacteria liquid, Rhodiola sachalinensis A.Bor is induced to grow hairy roots by genetic transformation; the PCR testing proves that hairy roots are generated by transformation; a fermenter is used for massive production of hairy roots, and precursor substances and elicitors are added to improve the Salidroside content. The method is applied to produce Salidroside to substitute the drying-up Rhodiola sachalinensis A.Bor resources.

The invention discloses a high-yield natural astaxanthin fermentation method, which comprises the steps as follows: activating phaffia rhodozyma CGMCC6355 bacterial strains and preparing a seed liquid; inoculating the seed liquid to a fermentation culture medium to perform fermentation culture, and extracting astaxanthin after the end of the fermentation culture, wherein before the fermentation culture, adding an oxygen vector with a volume ratio of 0.5-6 percent to the fermentation culture medium; during the fermentation culture, adding a sugar source to enable the concentration of reducing sugar in a fermentation liquid to reach 2-3 percent when the concentration of the reducing sugar in the fermentation liquid is consumed to below 2 percent, and adding an astaxanthin precursor substance to the fermentation liquid every other 8-24 hours. The astaxanthin produced by adopting the method can be applied to high-grade feed additives for the aquaculture industry and the like, and has the effects on improving the egg laying rate of aquatic animals, boosting the growth, and resisting and preventing diseases. The high-yield natural astaxanthin fermentation method is low in cost, high in the utilization ratio of raw materials, simple to operate, and easy to achieve large-scale industrial production.