130 results about "Gold nanorod" patented technology

The invention discloses a preparation method of a protein halo-coated silicon-coated gold nanorod and a PCR amplification method and kit based on the protein halo-coated silicon-coated gold nanorod, and belongs to the technical field of PCR detection. The photo-thermal nano material is composed of an AuNR coated SiO2 core-shell structure and an external protein halo layer, the protein halo layer avoids inhibition of AuNR on a PCR reaction system, meanwhile, adsorption of AuNR on biological small molecules is effectively reduced, non-specific amplification is reduced, and normal amplification of PCR reaction is guaranteed; and the protein halo layer is used as a thermal insulation layer to optimize heat exchange and maintain the temperature uniformity of the reaction liquid. When the kit is applied to a photo-thermal PCR detection reagent, DNA of a pathogen to be detected can be efficiently and stably amplified and detected within 10 minutes, the kit has huge application potential in the fields of early screening of infectious diseases, food safety detection and the like, collaborative optimization of photo-thermal conversion efficiency, biocompatibility, detection sensitivity and operation convenience is achieved, and the kit has a wide application prospect. And an efficient solution is provided for prevention and control of infectious diseases, food safety monitoring and biomedical research.

The invention belongs to the technical field of optical fiber sensing, and provides an optical fiber microstructure biosensor for detecting alpha fetoprotein and a preparation method thereof, and the method comprises the following steps: step 1, synthesizing a gold nanorod; 2, selecting a single-mode optical fiber for real-time monitoring, removing a coating layer, placing the single-mode optical fiber in a fusion splicer, drawing to obtain a micro-conical optical fiber, enabling CO2 laser to act on a conical waist area of the micro-conical optical fiber to manufacture a cone, taking out the optical fiber, and cooling and curing to obtain an optical fiber microstructure sensor; step 3, immersing a sensing area of the optical fiber microstructure sensor into NaOH, washing and drying, and immersing the sensing area into an MPTMS-ethanol solution; washing is carried out, and then the sensing area is immersed in a GNRs-PEG-COOH solution; washing and drying, immersing the sensing area in an EDC / NHS mixed solution for soaking, washing and drying, and putting the sensing area in an mAb solution for soaking; and washing and drying to obtain the optical fiber microstructure biosensor.

The invention discloses an optical fiber sensor and a preparation method thereof, and belongs to the technical field of optical fiber sensing, and the optical fiber sensor comprises an optical fiber body adopting a splicing structure of a single-mode optical fiber, a tapering coreless optical fiber and a single-mode optical fiber; the cascaded F-P structure comprises a sensing cavity and a reference cavity which are arranged on the tapering coreless optical fiber; the metal enhancement layer comprises a silver film and a gold nanorod array which are sequentially arranged on the surface of the tapering coreless optical fiber, the thickness of the silver film is 30-50 nm, the length-diameter ratio of gold nanorods is 3: 1-5: 1, and the diameter of the gold nanorods is 40-60 nm; the sensitive material coating comprises a polydimethylsiloxane (PDMS) film coated on the surface of the sensing cavity and a polyvinyl alcohol (PVA) film coated on the surface of the gold nanorod array, the thickness of the PDMS film is 3-7 microns, and the concentration of the PVA film is 2-4 wt%; according to the optical fiber sensor and the preparation method thereof provided by the invention, a synergistically enhanced sensing system is formed, and high sensitivity, amplification and multi-parameter detection capability are considered at the same time.

The invention provides a water-borne epoxy resin silicon steel sheet rapid curing self-adhesion coating, and relates to the technical field of curing coatings. The coating is prepared from water-borne epoxy resin emulsion, ureido pyrimidone modified epoxy resin, gold nanorod and silicon dioxide core-shell particles, silane modified carbon nanohorns, a cationic photoinitiator, a microencapsulated diaminodiphenylmethane curing agent, deionized water, propylene glycol methyl ether acetate and auxiliaries. The ureido pyrimidone modified epoxy resin, the gold nanorod and silicon dioxide core-shell particles, the silane modified carbon nanohorns and the microencapsulated diaminodiphenylmethane curing agent are added into the coating, so that the curing time of the coating is prolonged, meanwhile, a multi-layer stacked structure is formed after the coating is cured, and the adhesive force between the coating and a base material is improved.

The invention discloses a cyromazine concentration detection and analysis method and system, and relates to the technical field of pesticide residue detection.The method comprises the specific steps that a cyromazine detection chip is prepared, an integrated signal probe is prepared, a detection reaction system is constructed, triple cooperative response signals are collected, multiple signals are fused, and the cyromazine concentration is calculated; the cyromazine detection chip and the integrated signal probe are prepared, the fluorescence, electrochemistry and SERS triple synergistic response signal acquisition technology is combined, the accuracy of cyromazine concentration detection is improved, the gold nanoparticle modified substrate and the gold nanorod loaded fluorescence and electrochemical active substances are utilized, the response strength of the signal probe is enhanced, and the sensitivity of the signal probe is improved. The fluorescence spectrophotometer can detect cyromazine with lower concentration, meanwhile, the electrochemical workstation and the Raman spectrometer are introduced, so that the electrochemical peak current and SERS characteristic peak displacement are accurately acquired, signals from different sources are normalized, and errors existing among single signals are eliminated.

The invention relates to a preparation method of a platinum-doped hollow gold nanorod with high photo-thermal stability. The invention belongs to the technical field of nano material preparation. The preparation method comprises the following steps: adding a tellurium precursor substance and a selenium precursor substance into a hydrazine hydrate-containing solution, continuously magnetically stirring, and diluting by using an aqueous solution of lauryl sodium sulfate after the reaction is completed, so as to obtain the tellurium-selenium nanorod; and dispersing the prepared tellurium-selenium nanorod in pure water, adding a gold precursor, a platinum precursor and a modifier at the same time, and then performing centrifugal separation to obtain the platinum-doped hollow gold nanorod. The thermal stability of the hollow gold nanorod is effectively improved through platinum doping, and when the platinum doping proportion is 10% or above, the light and heat stability of the hollow gold nanorod is obviously improved; the positive significance is realized on the full play of the effect of the material in photo-thermal therapy and related combined therapy application.

The invention discloses an enhanced Raman scattering substrate for chiral molecule detection and a preparation method, and relates to the technical field of spectral analysis and chiral recognition. Chiral cysteine is induced at the core of the gold nanorod to form a spiral chiral gold-silver alloy layer and then wraps the zirconium-based metal organic framework, the synthesized chiral gold rod (at) MOF material has excellent LPSR effect and chiral electromagnetic field, and the MOF layer on the surface can well adsorb molecules to be detected to enter a plasma hot spot area. The Raman substrate is excellent in SERS performance. According to the composite material, through the dual effects of molecular enrichment and electromagnetic enhancement, enantiomers are distinguished directly through SERS intensity, and labeling or catalytic conversion is not needed.

The application discloses a kind of quantum dots of doped gold nanorod high-efficiency color conversion polarization LED device, it is related to the technical field of optoelectronic device, and the light box is used to improve luminous and color conversion efficiency.Light box is formed by bottom plate and fence and is not transparent to light emitting chamber, mounting hole is matched with LED chip and shields scattered light, realizes pure signal output, is helpful to light source and test area coaxial.Light box fixed position of light emitting element and color conversion layer board component, so that LED chip and color conversion film maintain optimal vertical excitation distance.Installation groove is equipped with light transmission bearing part and cooperates with reflection layer, and edge light is reflected to color conversion film.Color conversion film is coupled with the resonance of plasmon resonance peak and quantum dot light emitting peak by adjusting the length-diameter ratio of gold nanorod, and electric field is applied during film formation Induction gold nanorod directional arrangement, enhance the anisotropic coupling efficiency between gold nanorod and quantum dot.LED chip surface is equipped with subwavelength ridge microstructure, and total reflection loss is inhibited.The device structure is simple and can be 3D printed.

This invention relates to the field of food testing technology, and more particularly to a colorimetric LAMP method for the simultaneous visual detection of Vibrio vulnificus and Vibrio alginolyticus. The method employs a LAMP detection system composed of DNA-functionalized gold nanospheres and gold nanorods for detecting Vibrio vulnificus and Vibrio alginolyticus, respectively, and LAMP primer pairs. This allows for the detection and determination of the following states of Vibrio vulnificus and Vibrio alginolyticus: when neither pathogen is present, the solution is transparent; when both pathogens are present, the solution is purplish-red; when only Vibrio alginolyticus is present, the solution is gray; and when only Vibrio vulnificus is present, the solution is purple. This method can accurately determine the presence or absence of Vibrio vulnificus and Vibrio alginolyticus, and the specific type of bacteria, avoiding misjudgments, missed detections, and inaccurate traceability of these two types of pathogen contamination in food safety monitoring, clinical practice, and aquaculture protection.

The invention belongs to the technical field of superconducting material processing, and discloses a near-infrared optical response Nb3Sn superconducting wire and a preparation method thereof. The Nb3Sn superconducting wire with near-infrared optical response comprises an optical functional coating, the optical functional coating is formed by embedding periodically-arranged plasmon metal micro-nano structures into a high-transparency dielectric substrate, the plasmon metal micro-nano structures are gold nanorod arrays or silver nanoring, the dielectric substrate is made of a SiO2-polyimide composite material, and the thickness of the dielectric substrate is 10-20 micrometers. The Nb3Sn superconducting wire with the near-infrared optical response has high absorptivity and photoelectric response in the near-infrared band, in-situ optical sensing of temperature, stress and magnetic field intensity can be synchronously achieved, the interface compatibility of the optical functional coating and the Nb3Sn superconducting basic wire is good, meanwhile, the influence of the added optical functional coating on the performance of the superconducting wire is small, and the service life of the superconducting wire is prolonged. And the method has a wide application prospect in the aspect of constructing an integrated optical-electric-magnetic multifunctional device.

The present invention provides a protein detection method and detection preparation, which realizes efficient enrichment of target protein through mesoporous silica-graphene oxide composite nanoporous material, completes specific immune capture in combination with magnetic nanoparticles modified with targeted antibodies, and realizes single molecule separation using a microfluidic chip of a three-dimensional hydrogel antibody array. Signal amplification adopts enzyme-labeled secondary antibody-gold nanorod conjugate, enhances the fluorescence signal through the plasma resonance effect, and corrects the background noise in combination with a convolutional neural network algorithm, which significantly improves the detection reliability; experiments show that the detection limit of this method is as low as 0.12pg / mL, the linear range covers 0.5-100,000pg / mL, the single cell detection error is ±7.8%, the batch repeatability (CV=4.2%), the nonspecific adsorption rate is only 1.1%, and the detection time is shortened to 1.2 hours. The detection method of the present invention is suitable for ultra-sensitive detection of tumor markers, especially in the in situ analysis of CTCs with clinical application potential.

The invention relates to the technical field of preparation of bone cement, and particularly discloses a preparation method of a photo-thermal response type gold nanorod-bone cement composite material. The method comprises the following steps: synthesizing a gold seed solution; constructing a growth solution; controlling the growth of the nanorod; gradient centrifugal purification; carrying out surface ligand exchange (sulfydryl-PEG); preparing a bone cement composite material; curing and forming; gold nanorods (GNRs) are uniformly embedded into a polymethyl methacrylate (PMMA) bone cement matrix, so that the problems that free nanorods are easy to migrate and poor in bone targeting are solved. The local temperature can be accurately controlled, and damage to surrounding tissues is avoided. According to the invention, immunogen cell death (ICD) can be effectively induced, and anti-tumor immune response can be activated. According to the invention, enough mechanical support can be provided, and the stability after implantation is ensured.

The present invention provides a method for detecting and identifying molecular chirality based on a composite plasmon chiral nanostructure. The present invention constructs a composite plasmon chiral nanostructure using chiral nanofibers and gold nanorods as basic components, and achieves molecular chirality recognition and detection through plasmon chiral optical amplification. The excellent plasmon circular dichroism optical properties of the composite nanostructure can convert the host-guest chiral recognition interaction occurring at the fiber interface into an asymmetric plasmon chiral optical amplification signal. This technology can detect and identify the chiral enantiomers of amino acid molecules in about 1 minute, with a sensitivity of 10 ‑6 mol / L. This structure can also be used for quantitative analysis of molecular enantiomeric excess (ee), with a detection sensitivity of ±0.05. Furthermore, given that the chiral host-guest complexes involved in this technology are primarily based on hydrogen bonding interactions, the chiral fiber host can be used as a universal substrate for the detection of chiral amino acid molecules.

The invention discloses a spiral chiral gold nanorod as well as a preparation method and application thereof, and the method comprises the following steps: (1) sequentially adding hexadecyl trimethyl ammonium bromide, cysteine and p-aminothiophenol into an anisotropic gold nanorod solution, uniformly mixing, and adsorbing; and (2) silver nitrate, chloroauric acid and ascorbic acid are added for a reaction, centrifugal dispersion is performed after the reaction is finished, and the spiral chiral gold nanorod is obtained. Dispersing the spiral chiral gold nanorod in an aqueous solution, adding phenylalanine enantiomer, dropwise adding on a clean glass slide after incubation is finished, and performing surface enhanced Raman spectroscopy test by using a Raman microscope after air drying. According to the invention, the broadband coverage of chiral response from visible light to near ultraviolet region is realized by accurately regulating and controlling the arrangement of interface molecules and the morphology of the nano structure.

The application relates to a surface enhanced Raman detection technology, in particular to a spherical composite SERS substrate and a preparation method and application thereof. The method comprises the following steps: adopting a micro flow injection pump to drop a solution containing silver nanowires and gold nanorods into liquid nitrogen, and then performing freeze drying; wherein, a gun head of the micro flow injection pump is a hydrophobic gun head; the concentration of the silver nanowires in the solution containing the silver nanowires and the gold nanorods is 15-40 mg / mL. The spherical composite SERS substrate prepared by the method has a spherical structure formed by silver nanowires and metal nanorods, the spherical skeleton structure is formed by interweaving silver nanowires into a net, and the metal nanorods are loaded on the silver nanowires, and the spherical composite SERS substrate can realize detection of rhodamine 6G without introducing a modifier.

The present invention provides a multi-arm Anti-CD40 antibody-mediated nanometer dual-drug delivery system and its preparation method and application, belonging to the field of biomedicine technology. In the present invention, chromium ion-doped zinc gallate nanocrystals are embedded in silica-coated gold nanorod nanoparticles GNR@MSNs to prepare composite nanoparticles cGNR@MSNs, and then multi-arm DOTV is modified on the surface of the nanoparticles, and then anti-CD40 antibodies are covalently coupled to obtain the multi-arm Anti-CD40 antibody-mediated nanometer dual-drug delivery system. The multi-arm Anti-CD40 antibody-mediated nanometer dual-drug delivery system improves diagnostic accuracy by combining multimodal imaging, promotes the development of imaging-guided combined therapy, exerts the synergistic effect of chemotherapy, immunotherapy and photothermal therapy, optimizes the tumor treatment effect, is suitable for the treatment of various malignant solid tumors, and has good practicality.

The invention discloses a preparation method of natural polysaccharide-based organic / inorganic hybrid photo-thermal antibacterial hydrogel, which comprises the following steps: 1) mixing and dissolving methacrylated gelatin, hydroformylated sodium alginate, tannic acid and a photoinitiator in a phosphate buffer solution to obtain a solution A; 2) dissolving carboxymethyl chitosan in a phosphate buffer solution to obtain a solution B; 3) adding a gold nanorod aqueous dispersion into the solution B to obtain a solution C; the volume ratio of the gold nanorod aqueous dispersion to the solution B is (1.5: 1)-(2: 1), the length of the gold nanorod is 30-70nm, and the width of the gold nanorod is 5-10nm; 4) blending the solution A and the solution C, and injecting to obtain a network hydrogel I; and 5) carrying out ultraviolet irradiation crosslinking on the hydrogel I to obtain the dual-network hydrogel II. The antibacterial hydrogel can be formed in a mold with a complex shape, in-situ injection photo-crosslinking gel forming can be carried out, a photo-thermal heating effect under near-infrared light irradiation can be achieved, and the range required by photo-thermal antibacterial can be reached.

The invention discloses a micro-fluidic chip based on a polylysine and gold nanorod assembly array and a preparation method of the micro-fluidic chip. The micro-fluidic chip comprises a pressing cap top cover layer, a PMMA runner layer and a glass substrate which are sequentially arranged from top to bottom, a nucleic acid extraction runner is arranged in the PMMA runner layer, and the inner wall of the PMMA runner layer is covalently modified with a polylysine functional layer and a vertical-oriented periodic gold nanorod array in sequence; when a nucleic acid solution is injected into the nucleic acid extraction runner, nucleic acid is adsorbed under the synergistic effect of the cationic characteristic of polylysine and the high specific surface area of the gold nanorod; when the eluent is injected, the polylysine releases nucleic acid under the environment of specific ionic strength and pH, and the photothermal effect of the gold nanorod can assist in accelerating desorption. According to the micro-fluidic chip prepared by the invention, nucleic acid extraction is directly realized through the nucleic acid extraction runner, magnetic beads or microarrays are not needed, the cost is low, fluid control is simple, the adsorption efficiency is enhanced by the gold nanorod array, and the micro-fluidic chip is suitable for rapid and high-sensitivity nucleic acid detection.

The purpose of this invention is to provide a composite particle that singly blocks both ultraviolet light and infrared light at the same time, has good dispersibility and photothermal effect, and is highly safe. The present invention relates to a long ellipsoid-shaped composite particle comprising a Au nanorod, a Pt nanoparticle coating layer containing Pt nanoparticles provided on the surface of the Au nanorod, and a Au nanooutermost layer provided on the surface of the Pt nanoparticle coating layer.

This invention discloses an enhanced Raman scattering (SERS) substrate and its preparation method for chiral molecule detection, relating to the fields of spectroscopic analysis and chiral recognition technology. By inducing the formation of a helical chiral gold-silver alloy layer on a gold nanorod core with chiral cysteine ​​followed by encapsulation of a zirconium-based metal-organic framework, the synthesized chiral gold rod@MOF material not only exhibits excellent LPSR effect and chiral electromagnetic field, but the MOF layer on its surface can also effectively adsorb analyte molecules into the plasma "hot spot" region, making it a Raman substrate with superior SERS performance. This composite material, through the dual effects of molecular enrichment and electromagnetic enhancement, enables direct differentiation of enantiomers by SERS intensity without the need for labeling or catalytic conversion.

The present invention provides a method for accelerating the oxidative etching of gold nanorods by ferric ions using a carboxyl-containing thiol small molecule and its application. The method comprises the following steps: (1) adding a carboxyl-containing thiol small molecule to a mixed solution of incubated gold nanoparticles and a surfactant for incubation; (2) centrifuging the solution incubated in step (1), discarding the supernatant, dispersing the precipitate into an acidified surfactant solution, and then adding an etching solution containing ferric ions to initiate the etching reaction. The present invention utilizes a carboxyl-containing thiol small molecule to significantly accelerate the oxidative etching of gold nanoparticles by ferric ions and can be used to detect the spatial distribution of thiol molecules. The method is simple, rapid and highly reproducible.

The present invention discloses a photoluminescence-resonance light scattering dual-mode detection kit, which comprises: quantum dots, gold nanoparticles, gold nanostars or gold nanorods, an amino-modified aptamer molecule solution, and a thiol-modified aptamer molecule solution; a photoluminescence-resonance light scattering dual-mode biological detection system, which comprises: 1) co-incubating the quantum dots with the amino-modified aptamer molecule solution; 2) co-incubating the gold nanoparticles, gold nanostars or gold nanorods with the thiol-modified aptamer molecule solution; 3) mixing after incubation, and using photoluminescence-resonance light scattering dual-mode detection. Results show that the detection system has good sensitivity and reliability for detecting relevant biomarkers.

The present invention relates to: a biosensor for simultaneous multiplex detection of target nucleic acid molecules, the biosensor comprising gold nanorods with immobilized ssDNA and ssRNA; and a composition for diagnosing cancer using the biosensor. The present invention enables rapid simultaneous multiplex detection of cancer-associated cfDNA and miRNA, which are target nucleic acid molecules, to be performed with high accuracy and sensitivity, and thus can be advantageously used in the field of cancer diagnosis.

An endovascular system for targeted photothermal ablation of perivascular nerves is disclosed. A catheter includes a fluid lumen communicating with outlet orifices, and an electromagnetic radiation emitter positioned within a support structure that apposes the array against a vessel wall. A proximal console independently controls irradiation and injection parameters. In use, a nanofluid comprising plasmonic nanoparticles, such as gold nanorods tuned for near-infrared absorption, is injected into or through the vascular wall and subsequently irradiated intraluminally; the nanofluid absorbs energy and converts it to heat to ablate adjacent nerve fibers while reducing non-target tissue heating.

The invention discloses a gold nano array sensor and a method for efficiently and rapidly identifying the multielement form of phosphorus in wastewater, the gold nano array sensor comprises four groups of functionalized gold nano particle probe units, and the functionalized gold nano particle probe units are composed of nanogold probes modified by four surface modifiers, the first unit is a nanogold probe modified by amino / sulfydryl bifunctional molecules, the second unit is a nanogold probe modified by rare earth metal ions, the third unit is a nanogold probe modified by a quaternary ammonium salt type surfactant, and the fourth unit is a nanogold probe modified by a quaternary phosphonium salt type surfactant. The gold nano array sensor disclosed by the invention is based on multi-wavelength detection, and realizes rapid identification and quantitative detection of different phosphorus forms in wastewater through qualitative and quantitative analysis of multi-dimensional data. The method does not need a complex pretreatment process, has the advantages of short detection time, simplicity and convenience in operation, high sensitivity, strong anti-interference capability and the like, and provides an innovative thought for the distinguishing and concentration detection combined analysis of phosphorus species in industrial wastewater.

The invention discloses a controllably prepared gold nanorod self-assembled array SERS (Surface Enhanced Raman Scattering) substrate as well as a preparation method and application thereof, and relates to the technical field of SERS (Surface Enhanced Raman Scattering) detection. The substrate comprises a silicon wafer and a surface self-assembled PVP modified gold nanorod array (the length-diameter ratio is 2.5 / 3.1 / 3.5 / 4.2, optimally 3.5), and the array is a continuous compact single-layer film and is excellent in uniformity and reproducibility. The preparation method comprises the following steps: synthesizing gold nanorods by adopting a seed crystal method, and preparing the substrate through three-phase self-assembly (dispersion liquid, dichloromethane, water and normal hexane); during application, a honey sample is pre-treated by a Carrez reagent and then is applied to a substrate, 785nm laser Raman detection is carried out (the characteristic peak is 1524cm <-1 >), the standard substance detection limit is 0.1 mg / L, the honey detection limit is 1mg / L, the adding standard recovery rate is 73.32%-95.92%, and the method is suitable for accurate detection of honey 5-HMF.

The present invention discloses a temperature-responsive two-photon MOF-based fluorescent probe, its preparation method, and application, relating to the field of fluorescent probe technology. MOF-199 is used as a nanocarrier, simultaneously loaded with a photothermal agent, gold nanorods (Au NRs), and a temperature-responsive pyridinium salt molecule (B). MOF-199 can degrade in the acidic tumor microenvironment, and the released copper ions react with overexpressed H2O2 through a Fenton-like reaction to generate ·OH, inducing tumor cell apoptosis and achieving chemodynamic therapy. Au NRs, with high photothermal conversion efficiency, can achieve photothermal therapy under near-infrared light irradiation, and local hyperthermia can further accelerate ·OH generation, thereby accelerating the chemodynamic therapy process. B, with its two-photon response characteristics, can achieve real-time temperature monitoring under near-infrared light irradiation, and the coated phase change material film can effectively prevent B leakage, achieving temperature-controlled release.

The invention discloses a preparation method of a suspending agent containing lambda-cyhalothrin and chlorantraniliprole, and relates to the technical field of pesticides. Comprising the following steps: uniformly mixing lambda-cyhalothrin and chlorantraniliprole, adding a hydrogen bond directing agent, adding an ethyl acetate-ethanol mixed solvent, and grinding; the preparation method comprises the following steps: dissolving N-isopropylacrylamide and acryloylated chitosan in water, adding gold nanorods, introducing nitrogen, injecting an initiator, and dialyzing and purifying; dissolving the co-crystallized powder in tetrahydrofuran, dispersing the composite gel in a choline propionate aqueous solution containing polyoxyethylene-polylactic acid, slowly adding the liquid medicine into a gel dispersion liquid, simultaneously carrying out ultrasonic treatment, and dialyzing to obtain a drug-loaded nanogel suspension; respectively adding glycerol and sodium citrate, homogenizing, shearing, adjusting the pH value, filtering with a filter membrane, and sterilizing; liquid medicine is loaded in a temperature-sensitive gel network, and a photothermal conversion material is introduced, so that on-demand release under the triggering of near-infrared light is realized.

The application belongs to the technical field of biological medicine, and relates to construction and application of a kind of nano oxygen delivery system based on internal peroxide. The application designs and synthesizes a kind of nano drug which can be used as a molecular oxygen delivery agent. In the nano drug, active molecules are composed of internal peroxide compound and 1,4-diazabicyclo[2.2.2]octane (DABCO), and the two molecules are constructed on gold nanorods to improve water solubility, biocompatibility and targeting of the active molecules. Finally, the active molecule modified gold nanorods obtained by the application can be used to relieve the damage of tissues and organs caused by hypoxia.

The invention relates to a phthalate detection method based on gold nanorods and aptamers, which comprises the following steps: firstly, synthesizing positively charged gold nanorods, and neutralizing positive charges on the surfaces of AuNRs by using negatively charged aptamers to aggregate the AuNRs; auNRs aggregation is regulated and controlled through the action of DEHP and the aptamer, rapid visual detection of DEHP is achieved, and the detection limit can reach 4.2 nM. The detection sensitivity is high. The method is simple, convenient and rapid in operation process and high in sensitivity, does not need complex sample pretreatment and large-scale instruments and equipment, has strong practicability, has been used for detecting DEHP content in various actual water samples and food samples, and has wide application prospects in the aspects of food safety evaluation and environmental monitoring.