700 results about "Gold nanorod" patented technology

The invention discloses a top silver-cladding gold nanorod array and a preparation method and application thereof. In the array, a gold film is provided with a gold nanorod array of which the top end is cladded with silver nanoparticles with the diameters of between 60 and 90nm, and the bottom surface is provided with an organic matter substrate with the thickness of between 50 and 100 mu m. The method comprises the following steps of: evaporating the gold film on one side of a nano through-hole alumina template, and growing the gold nanorod array in the hole of the template, particularly coating a liquid organic matter on the gold film on one side on which the gold nanorod array does not grow; evaporating the gold film on one side after the liquid organic matter is cured; placing the alumina template of which the hole is deposited with the gold nanorod array and the gold film is coated with the organic matter in acid or alkali solution; etching off the template; and evaporating silver on the top of the gold nanorod array by film evaporating technology to obtain the top silver-cladding gold nanorod array. A trace amount of organic matter rhodamine or 2,3,3'-trichlorodiphenyl can be detected by using the surface enhanced raman scattering effect of the top silver-cladding gold nanorod array.

The invention discloses a method for preparing gold nano-rods. The method includes the steps: adding chloroauric acid solution and optional gold seed generating regulating agents into CTAB (cetyl trimethyl ammonium bromide) solution, adding silver nitrate solution, weak reducing agents and strong reducing agents into the CTAB solution and reacting at the constant temperature of 25-40 DEG C for 5-30min to obtain reaction liquid A; and adding silver nitrate solution, optional gold nano-rod growth regulating agent solution and water into the reaction liquid A to obtain reaction liquid B, and continuing reaction to obtain the gold nano-rods. The method is simple in process and operation and fine in reproducibility, the diameter of coverage of the prepared gold nano-rods is as small as 5nm to tens of nanometers, LSPR (localized surface plasmon resonance) peak value coverage in the length direction ranges from 630nm to 1010nm, counts in a TEM (transmission electron microscopy) graph indicate that more than 90% of rod products among obtained gold nano-particle products are high in rod yield, and the ratio of an LSPR peak value to a TSPR (transverse surface plasmon resonance) peak value is not lower than 2 in a UV-Vis (ultraviolet visible) absorption spectrogram. Raw materials used in the method are widely and easily obtained, and production cost is low.

The invention discloses a dual-mode optical coding probe and a preparation method thereof. The probe is in a three-layer core-shell structure, the first-layer core is a gold nano bar, the second-layer shell is silica, the third-layer shell is a cadmium telluride quantum dot, the second-layer shell is wrapped on the outer side of the first-layer core, the third-layer shell covers the outer side ofthe second-layer shell in a sticking mode, and the outer surface of the first-layer core is stuck with Raman molecules which are wrapped by the second-layer shell. The preparation method of the dual-mode optical coding probe comprises the following steps of: 1, preparing an original gold nano bar solution; 2, preparing gold nano bars marked by the Raman molecules; 3, preparing a gold nano bar andsilica metal medium composite nano ball solution; and 4, preparing the dual-mode optical coding probe. The dual-mode optical coding probe has the joint encoding capacity of fluorescence and SERS (Surface Enhanced Raman Scattering), and enhances the optical coding capacity. The preparation method of the dual-mode optical coding probe has a simple process and high repeatability.

The invention discloses a pH-responsive anti-tumor drug carrier material and a preparation and application of the pH-responsive anti-tumor drug carrier material. The preparation method comprises the following steps that (1) gold nanoparticles wrapped by mesoporous silica are prepared, and the gold nanoparticles comprise gold nanospheres or gold nanorods; (2) gold nanoparticles wrapped by carboxylation mesoporous silica are prepared; (3) water-soluble zinc oxide quantum dots are prepared; and (4) the pH-responsive anti-tumor drug carrier material is prepared. According to the pH-responsive anti-tumor drug carrier material and the preparation and application of the pH-responsive anti-tumor drug carrier material, the whole technological process design of the preparation method, the parameter conditions adopted by the reaction steps and the like are optimized, and the existing problems that drug releasing is uncontrollable, the drug loading capacity is low, and side effects are prone to being caused when the gold nanoparticles wrapped by the mesoporous silica serve as a drug carrier can be effectively solved.

The invention discloses a gold nanorod-silicon dioxide core-shell structure nanometer material. The core structure of the core-shell structure nanometer material is a chiral gold nanorod side-by-side assembly with the circular dichroism optical activity. The shell structure of the core-shell structure nanometer material is silicon dioxide. The core of the chiral gold nanorod side-by-side assembly is coated with the silicon dioxide shell layer, so that the nanometer material with the circular dichroism optical activity is obtained. According to the nanometer material, the side-by-side assembly structure is stable, the solution state is stable, and the circular dichroism optical activity is obviously improved, wherein the circular dichroism optical activity is improved by 4-6 times compared with a pure chiral gold nanorod, and the stability is kept as long as 6 months. A preparation method of the gold nanorod-silicon dioxide core-shell structure nanometer material is simple and low in cost. The obtained chiral gold nanorod side-by-side assembly-silicon dioxide core-shell structure nanometer material has various compositions and properties, is wide in application range and has the large development space.

The invention discloses a nano-carrier particle controllable in drug release, which has a three-layer core-shell structure and comprises outer-layer mesoporous silica, an interlayer silica shell layer and an inner-layer gold nanorod; drug is loaded in the mesoporous silica; raman molecule is coated on the silica shell layer; the raman molecule is marked on the gold nanorod; the drug is connected on the mesoporous silica by a molecule containing a disulfide bond in a manner of a covalent bond, and the disulfide bond is cut off under the action of glutathione in a cell, so as to release the drug molecule. The invention also discloses a preparation method of the nano-carrier particle controllable in drug release. The nano-drug carrier particle and the preparation method can effectively avoid advance leakage of the drug and reduce the toxic and side effects of the drug, and simultaneously, SERS (surface enhanced raman scattering) signals are integrated in the nano-drug carrier particle, so that precise optical tracing on the nano-drug carrier particle is realized, great convenience is brought to the research on administration behavior, and can effectively improve the cancer chemotherapy efficiency.

The invention relates to a saturable absorber based on a plasmon axial vibration mode and belongs to the technical field of pulse laser. The invention particularly relates to a novel saturable absorber which consists of gold nanorods and film forming agent and can be used for mode-locked fiber lasers. The saturable absorber based on the gold nanorods can be prepared by adopting the method which comprises the steps of mixing the gold nanorod water dispersion and film forming agent water solution according to a molar ratio of (8-133):1, and performing ultrasonic dispersion for 2-5hours; and finally spin-coating the mixed solution on surfaces of flat silicon wafers and naturally drying the silicon wafers in a vacuum closed container till films are formed. The output of pulse laser at a near-infrared band is realized by using the unique longitudinal surface plasma resonance absorption characteristic of the gold nanorods. The saturable absorber based on the plasmon axial vibration mode enables the types of saturable absorbers to be expanded and can be widely used for mode locking of lasers at a visible-near infrared band.

The invention provides a method for preparing surface enhanced Raman substrate, and relates to Raman spectrums. The method comprises the steps that a seed crystal growing method is used for synthetizing a gold nanorod solution, wherein gold nano seeds are synthetized first, then a growing solution is added, silver nitrate is used for adjusting the slenderness ratio of gold nanorods until reaction is completed, the needed gold nanorod solution is obtained, then centrifuging is conducted to remove supernatant liquor, signal molecules are added to be connected to a gold surface, then a polyethylene glycol dressing agent is added to induce the gold nanorods to conduct self-assembling, then a processed nano particle solution is stirred, a TEOS methanol solution is added for reacting, silicon dioxide layers are wrapped on the surfaces of the self-assembled gold nanorods, and the surface enhanced Raman substrate is obtained. Detecting can be directly conducted in the solution, due to self-assembling and the coupling effect of plasma on the surfaces of adjacent nano particles, the electromagnetic field between the nano particles is obviously enhanced, the Raman signals at the position are amplified in a quantity level mode, accordingly, the detecting sensitivity of surface enhanced Raman is greatly improved, and the stability is high.

The invention discloses a method for rapidly preparing a gold nanorod, which belongs to the technical field of a nano material, and solves the problem that the existing gold nanorod seed induction growth method is long in consumed time. The method is characterized in that cationic surface active agent chloride quaternary ammonium salt is used as a protective agent, gold seeds which are obtained by reducing sodium borohydride through the reducing agent sodium oleate, ascorbic acid are added into a chloroauric acid solution under the assistant effect of ions and silver ions to obtain gold nanorods. According to the method, the synthesis of the gold nanorods can be completed in 15 minutes, so that not only can the synthesis time of the gold nanorods be greatly shortened and a material base be provided for the real application of the gold nanorods, but also the yield of the gold nanorods is high, and fewer spherical particles exist.

The invention discloses a method for preparing gold nanorods and belongs to the field of nano material preparing. The method includes the following steps that firstly, a mixed solution of quaternary ammonium bromide, oleate, chloroauric acid hydrated, silver nitrate, an acid solution and ascorbic acid is prepared, and a growth solution is obtained; secondly, in a cetyl trimethyl ammonium bromide surface modifying solution, strong reductant sodium borohydride is used for restoring the chloroauric acid hydrated to obtain a gold seed solution; thirdly, the gold seed solution is injected into the growth solution for reaction for 3-15 hours, and the gold nanorods are obtained. The method for preparing the gold nanorods has the advantages that the requirement for equipment is low, the method is easy to operate, conditions are gentle, reproducibility is high, and large-batch preparing can be conducted; the obtained gold nanorods are high in yield which can reach 99 percent or higher, consistency is high, the variable coefficient of length and the variable coefficient of width are within 10 percent, the length-diameter ratio can be regulated in the large range of 1.5-8, and a solid foundation is laid for practical use of the gold nanorods.

The invention relates to a method for performing supersensitive detection on fungaltoxin of a DTNB mark-based gold@silver core-shell nanorod, and belongs to the technical fields of food safety, environment monitoring and the like. The gold nanorod is prepared by a seed growing method, 5,5'-dithio-bis(2-nitrobenzoic acid) (DTNB) is marked on the gold nanorod, meanwhile, the gold nanorod is coated with a silver shell layer to prepare a gold@DTNB@silver surface Raman enhanced substrate, a superparamagnetic magnetic material chitosan ferroferric oxide is prepared, a fungaltoxin aptamer complementary chain is coupled on the prepared Raman enhanced substrate, a fungaltoxin aptamer chain is coupled on the magnetic material, an enhancer and the magnetic material are combined and a Raman signal of a system is strongest when the fungaltoxin does not exist in the detection system, and the aptamer modified magnetic material is specifically and preferentially combined with the fungaltoxin and the Raman signal of the system is changed after an external magnetic field is separated when the fungaltoxin exists, so that the aim of quantitatively detecting the fungaltoxin is fulfilled.

A nanoagent includes at least one nanocomposite. The nanocomposite includes at least one gold nanorod, a silver layer coated on an outer surface of the gold nanorod, a Raman reporter molecule layer coated on the silver layer, a pegylated layer coated on the Raman reporter molecule layer, an active layer conjugated to the pegylated layer. the active layer includes at least one of a targeting molecule configured to bind to a target of interest, and a functional molecule configured to interact with the target of interest. The silver layer has silver nanoparticles. The Raman reporter molecule layer has Raman reporter molecules that are detectable by surface enhanced Raman spectroscopy (SERS). The pegylated layer has at least one of thiolated polyethylene glycol (HS-PEG), thiolated polyethylene glycol acid (HS-PEG-COOH) and HS-PEG-NHx.

The invention provides a composite gold nanorod carrier having photo-thermal/photodynamic therapy treatment performance and a preparation method thereof. The composite gold nanorod carrier uses a gold nanorod as a core and uses silicon dioxide as a shell layer, a near infrared fluorescent dye for photodynamic therapy is modified on the outer surface of the shell layer. The preparation method comprises the steps that a chloroauric acid solution and a cetyl trimethyl ammonium bromide solution are mixed, a sodium borohydride ice water mixed solution is added to obtain a nano gold seed solution A; a silver nitrate solution and a chloroauric acid solution are added to a binary surface active agent solution, a hydrochloric acid is added after reaction to obtain a solution B, then ascorbic acid and the solution A are added, and a gold nanorod is obtained after reaction; a tetraethoxysilane methanol solution and an aminopropyl trimethoxy silane methanol solution are added to a gold nanorod solution to obtain composite nanoparticles; 1-(3-dimethyl amino propyl)-3-ethyl carbodiimide hydrochloride is added to the near infrared fluorescent dye, then N-hydroxyl succinimide is added to obtain a solution C; the composite nanoparticle solution is mixed with the solution C to obtain a product.

The invention discloses a preparation method of a gold nanorod array. The method includes the steps that a gold nanorod aqueous solution modified by cetyl trimethyl ammonium bromide (CATB) is prepared; the final concentration of gold nanorods and the final concentration of the CATB are adjusted to be 0.2-0.6 nmol/L and 0.5-2 mmol/l respectively; sulfhydryl compounds are added and stirred, and a mixed solution can be obtained; the final concentration of the sulfhydryl compounds is 0.01-0.2 mmol/L; after being concentrated, the mixed solution is dripped to a hydrophilic planar substrate; and the gold nanorod array is obtained after natural drying. The preparation method of the gold nanorod array is easy to operate and mild in condition. The prepared gold nanorod array is regular in structure and at the macroscopic millimeter level; and evenly-distributed SERS hot spots are arranged on the surface of the gold nanorod array, and therefore the gold nanorod array can serve as an SERS enhanced substrate easily. The invention further provides the gold nanorod array and application thereof.

The invention provides a nano rod and a preparation method and application thereof. The preparation method includes: in the presence of solvent, allowing soluble platinum salt, soluble copper salt and reducing agent to be in contact with a gold nano rod, wherein for each mol of gold atom, 0.1-0.5mol of soluble platinum salt is used, 0.01-3mol of soluble copper salt is used, and 2-20mol of reducing agent is used. The nano rod prepared by the method has CuPt alloy nano island structures, selectivity on substrate catalyzing and high catalyzing efficiency are achieved, the catalytic activity, on an OPD, TMB+H2O2 system and H2O2, of the nano rod is evidently higher than that of the gold nano rod having only deposited platinum on the surface, and the nano rod prepared by the method is applicable to the fields of chemical and biological catalysis. In addition, the CuPt alloy nano island structures gather to two ends of the gold nano bar when the use amount of the soluble copper salt and the soluble platinum salt is increased, and accordingly nano rods of different morphologies and components can be obtained by the method.

The invention discloses a simply synthesized gold nanorod-CdS-gold nanoparticle composite photocatalyst with visible and near-infrared light response. The photocatalyst is used for organic synthesis in a water phase and prepared from two Au nanostructures (gold nanorods and gold nanoparticles) different in morphology and one-dimensional semiconductor CdS nanowires by a simple electrostatic self-assembly method. For the first time, the simply synthesized gold nanorod-CdS-gold nanoparticle composite photocatalyst is used for photocatalysis in the water phase to realize selective reduction for substitution of nitrobenzene. The photocatalyst has high catalysis efficiency and high selectivity. In addition, the preparation process is simple, selective reduction for substitution of the nitrobenzene is realized by taking the visible and near-infrared light as driving energy, water as a solvent and nitrogen as a shielding gas, and sustainable development of environment and energy is benefited.

The invention relates to an electrochemiluminescence immunosensor for detecting beta-amyloid protein and construction of the electrochemiluminescence immunosensor. The sensor comprises a magnetic glassy carbon electrode and Fe3O4-expoxy, a mesoporous carbon @Ru(bpy)32+/beta-amyloid protein antibody composite nanometer composite material, beta-amyloid protein to be detected with different concentrations and a gold nanorod-beta- beta-amyloid protein aptamer nanometer composite material, wherein the Fe3O4-expoxy, the mesoporous carbon @Ru(bpy)32+/beta-amyloid protein antibody composite nanometer composite material, beta-amyloid protein to be detected with different concentrations and the gold nanorod-beta- beta-amyloid protein aptamer nanometer composite material are synthesized on the surface of the magnetic glassy carbon electrode in sequence. Compared with the prior art, the electrochemiluminescence immunosensor has the advantages that the constructing method is simple, detection on Alzheimer's disease markers (beta-amyloid protein and the like) is high in speed, high in sensitivity, high in specificity, low in detection limit, wide in detection range and the like, and the application of the electrochemiluminescence immunosensor provides a new thought for early diagnosis of the Alzheimer's disease and detection of markers of other diseases.

The invention discloses a silver-gold porous nanorod array, a preparation method and a purpose of the silver-gold porous nanorod array. The array comprises porous gold nanorods coated with 3-15nm silver films and arranged on a methyl methacrylate substrate coated with a gold film, wherein the nanorods are 150-250nm in length, and 50-70nm in diameter; and holes are 5-20nm in diameter. The method comprises the steps of placing an aluminum oxide template coated with a gold film in a mixed electrolytic solution for electro-deposition, obtaining an aluminum oxide template coated with the gold film and provided with a gold-silver alloy nanorod array deposited in holes, placing the aluminum oxide template in a nitric acid solution for reaction to obtain an aluminum oxide template coated with the gold film and provided with a porous gold nanorod array in holes, coating the other side of the gold film with liquid methyl methacrylate, solidifying, then sequentially placing the aluminum oxide template in a silver nitrate electrolytic solution for the electro-deposition and aqueous alkali for removing the aluminum oxide template, or sequentially placing the aluminum oxide template in aqueous alkali for removing the aluminum oxide template, coating a silver film by an ion sputtering method, and obtaining the objective product. The array can serve as an SERS (Surface Enhanced Raman Scattering) activity substrate for detecting trace organic matters.

A nanoagent for surface enhanced Raman spectroscopy (SERS) detection of a target of interest, includes one or more nanocomposites. The target of interest may include at least one tumor cell or at least one pathogen. Each nanocomposite includes at least one gold nanorod, a silver layer coated on a surface of the gold nanorod and having silver nanoparticles, a Raman reporter molecule layer assembled on the silver layer and having Raman reporter molecules, a pegylated layer coated on the Raman reporter molecule layer, and an antibody layer conjugated to the pegylated layer. The different nanocomposites of the nanoagent can be represented by different colors when SERS images are collected upon the nanoagent.

The invention discloses an ordered porous gold nanorod array and a preparation method and application thereof. The array is that the porous gold nanorod array is arranged on a methyl methacrylate substrate coated with a gold film. Length of porous gold nanorods on the gold film is 150-250nm, diameter of the nanorods is 50-70nm, and diameter of upper holes of the nanorods is 5-20nm. The method includes: an alumina template with one surface plated with a gold film is placed in mixed electrolyte to perform electrolytic deposition, the alumina template with the gold film plated on one surface and gold-silver alloy nanorods arrays deposited in holes is obtained, the alumina template is placed in a salpeter solution to react to obtain the alumina template with the gold film plated on one surface and porous gold nanorod arrays placed in the holes, liquid-state methyl methacrylate is coated on the other surface of the gold film of the alumina template with the gold film plated on one surface and porous gold nanorod arrays placed in the holes, the alumina template with the gold film plated on one surface and porous gold nanorod arrays placed in the holes is placed in an alkali solution to remove the alumina template after the liquid-state methyl methacrylate is solidified, and a target product is obtained. The ordered porous gold nanorod array can be used as a surface enhanced Raman scattering (SERS) active substrate to detect trace rhodamine.

The invention provides a piezoelectric composite dressing for promoting peripheral nerve repair and wound healing and loading exosome of traditional Chinese medicine and a preparation method. The preparation method comprises the following steps that gelatin and methacrylic anhydride react to prepare methacrylate gelatin; the exosome of the Chinese medicine is prepared through differential centrifugation;a conductive pregel system is prepared through the recombination of gold nanorods, the exosome and the methacrylate gelatin; and the conductive pregel and a polyvinylidene fluoride ethylene piezoelectric thin film arerecombined, and the piezoelectric composite dressing is prepared. The dressing prepared by the preparation method is a novel dressing for piezoelectric stimulation composite medicine action, polyvinylidene fluoride ethylene produces electricity potential to stimulate a wound area through the conductive gel, wound healing and nerve regeneration are promoted with the exosomeof the traditional Chinese medicine, and the problems in the current wound repair and nerve repair process can be effectively solved. Therefore, the composite dressing has a wide application value inthe treatment of trauma and nerve repair.