333 results about "Solution state" patented technology

A stabilized human monoclonal antibody preparation containing 1 to 20 mg of D-mannitol per 1 mg of a human monoclonal antibody. This preparation is excellent in stability in a solution state, a freeze drying state and a freezing state, particularly stability against aggregation and precipitation of the human monoclonal antibody at the time of redissolution after freeze drying.

The invention provides a preparation method of polyinosinic-polycytidylic acid dry powder. The method comprises the following steps: (1) respectively dissolving polyinosinic acid and polycytidysic acid in a phosphate buffer solution, mixing the solution, adding a stabilizer, uniformly mixing the stabilizer and the solution, and performing heat preservation on the mixture at the temperature of 40-100DEG C; (2) naturally cooling the reaction liquid obtained in the step (1), mixing the reaction liquid with an organic solvent, standing for precipitating, and drying the precipitate, thereby obtaining the polyinosinic-polycytidylic acid dry powder. The preparation method has the beneficial effects that the prepared polyinosinic-polycytidylic acid dry powder has a complete double-helix structural features and physiological activity, the quality and the stability are better than those of the polyinosinic-polycytidylic acid at a solution state, a stronger enzymolysis-resisting performance can be achieved compared with the bare polyinosinic-polycytidylic acid after entering a living body, so that the curative effect can be enhanced. The polyinosinic-polycytidylic acid is purified in the process for making the polyinosinic-polycytidylic acid solution into the dry powder, a plurality of small-molecular-weight substances and impurities can be removed, the toxic and side effects can be reduced, and the quality of the polyinosinic-polycytidylic acid can be improved.

The invention is to provide such a polymerizable liquid crystal composition that is excellent in stability in a solution state, shows good coating property on a supporting substrate, and has uniform homeotropic alignment property. The polymerizable liquid crystal composition of the invention contains an acrylate compound and a bisphenol fluorene compound. The bisphenol fluorene compound is effective for controlling uniform homeotropic alignment of the polymerizable liquid crystal composition.

The invention discloses a gold nanorod-silicon dioxide core-shell structure nanometer material. The core structure of the core-shell structure nanometer material is a chiral gold nanorod side-by-side assembly with the circular dichroism optical activity. The shell structure of the core-shell structure nanometer material is silicon dioxide. The core of the chiral gold nanorod side-by-side assembly is coated with the silicon dioxide shell layer, so that the nanometer material with the circular dichroism optical activity is obtained. According to the nanometer material, the side-by-side assembly structure is stable, the solution state is stable, and the circular dichroism optical activity is obviously improved, wherein the circular dichroism optical activity is improved by 4-6 times compared with a pure chiral gold nanorod, and the stability is kept as long as 6 months. A preparation method of the gold nanorod-silicon dioxide core-shell structure nanometer material is simple and low in cost. The obtained chiral gold nanorod side-by-side assembly-silicon dioxide core-shell structure nanometer material has various compositions and properties, is wide in application range and has the large development space.

A method of manufacturing a wafer-level flip chip package is capable of being used to produce a flip chip package by directly coating a flip chip package using anisotropic conductive adhesives (ACA) and non conductive adhesives (NCA) in a solution state as a double layer on a wafer. The method can be used to manufacture a non-conductive mixed solution and a conductive mixed solution and directly coat them on a substrate, such that it is possible to: increase productivity; simplify a manufacturing process; suppress a shadow effect; easily perform thickness control that is difficult with the anisotropic conductive adhesive paste or the non-conductive adhesive paste; and obtain the non-conductive layer and the anisotropic conductive layer in an initial state of a B-stage with a level not losing latent of hardening through a simple drying process to volatilize an organic solvent. Above all, the non-conductive layer and the anisotropic conductive layer is sequentially stacked on the substrate formed with the non-solder bump, making it possible to make the selectivity of electrical conduction and the stability of a connection process excellent, shorten process time and costs, and dramatically reduce consumption of the conductive particles which account for a large portion of total production costs.

Such a polymerizable liquid crystal composition is to be provided that is excellent in stability in a solution state, shows good coating property on a supporting substrate, and has a uniform homeotropic alignment property. The polymerizable liquid crystal composition contains an acrylate compound, an epoxy compound and a bisphenol fluorene compound. The polymerizable liquid crystal composition contains a compound selected from a group of compounds represented by formulae (1-1) and (1-2) as a component (A), a compound selected from a group of compounds represented by formula (2) as a component (B), a compound selected from a group of compounds represented by formulae (3-1) to (3-3) as a component (C) and a compound selected from a group of compounds represented by formulae (4-1A), (4-1B), (4-2), (4-3), (4-4) and (4-5) as a component (D), and may optionally contain a compound selected from a group of compounds represented by formulae (5-1) and (5-2) as a component (E). The bisphenol fluorene compound is effective for controlling a uniform homeotropic alignment of the polymerizable liquid crystal composition.

The invention relates to a beta titanium alloy, in particular to a beta titanium alloy with low cost and high strength and a preparation method thereof. The beta titanium alloy comprises the following components in mass percentage: 0.5%-2.5% of ferrum, 1.5%-3.5% of aluminum, 2%-4% of chromium, 6%-11% of niobium and the balance of titanium. The preparation method comprises the following steps of: smelting sponge-state titanium and then smelting the smelted titanium with ferrum, aluminum, chromium and niobium to obtain a beta titanium alloy ingot; and cooling the beta titanium alloy ingot along with a furnace after uniform heat treatment, hot rolling the cooled beta titanium alloy ingot into a sheet alloy material, cutting the sheet alloy material into samples, carrying out ice water quenching after solution treatment and then carrying out ageing treatment to obtain the beta titanium alloy with high strength. The results of stretching experiments indicate that the room-temperature tensile strength of the beta titanium alloy in the solution state is above 850 MPa, and the elongation is above 15%; and the room-temperature tensile strength of the beta titanium alloy in the ageing state is above 1300 MPa, the elongation is above 4%, the strength of the beta titanium alloy can achieve above 1300 MPa, and meanwhile, the beta titanium alloy keeps a certain plasticity.

The invention belongs to a synthesis method for preparing nano-titania sol and powder, and in particular relates to a synthesis method for preparing rutile nano-titania sol or powder at a low temperature. The synthesis method comprises: dissolving a mineralizer into an aqueous solution containing titanium salt, obtaining the mineralizer-doped aqueous solution containing the titanium salt, using inorganic alkali to adjust the pH value of the solution to be between 5 and 11 or using water to dilute the mineralizer-doped aqueous solution containing the titanium salt or heating the mineralizer-doped aqueous solution containing the titanium salt, and obtaining composite titanate deposit; using superoxol to disperse the composite titanate deposit into solution state, and adjusting the pH value of the composite titanate solution; adjusting the pH value to be more than 1 in order to obtain the sol; adjusting the pH value to be less than or equal to 1 in order to obtain the powder; heating the solution; obtaining the yellow orange transparent or semitransparent nano titania sol when the pH value is more than 1; and obtaining white deposit when the pH value is less than or equal to 1, and obtaining the nano titania powder after centrifugation or filtration. The synthesis method greatly reduces the cost and simplifies the technology.

The invention discloses an ammonification method of polyacrylonitrile polymerization liquid and a device for realizing the same. The method comprises the following steps: (1) dissolving acrylonitrile, copolymerization monomers and an initiator in a solvent in a polymerization kettle by adopting a solution polymerization process, and carrying out copolymerization reaction in a solution state to obtain the polyacrylonitrile polymerization liquid; (2) adding a certain amount of solvent to a container, and introducing ammonia gas to the solvent to obtain NH3 solution, wherein the solvent is same as that used in the step (1); and (3) adding a proper amount of the polyacrylonitrile polymerization liquid obtained in the step (1) and a proper amount of the NH3 solution obtained in the step (2) toa mixer, and uniformly mixing to realize uniform ammonification of the polyacrylonitrile polymerization liquid. Compared with the existing ammonia gas bubbling method, the ammonification method overcomes the defects that ammonia gas is difficult to meter and mix and generates pollution to the polymerization kettle, improves the ammonification controllability and uniformity, and lays a foundation for production of stable and high-performance PAN (polyacrylonitrile) protofilament.

Provided herein are biomolecular hybridization devices comprising a substrate with a permanently and covalently attached surface of functional groups and an adsorbed monolayer of unmodified, single-stranded oligonucleotides all of which are 10 to about 24 bases in length as a saturated film of constrained oligonucleotides on the surface via direct non-covalent phosphate-surface adsorptive contact of substantially all phosphate groups of each oligonucleotide. The constrained oligonucleotides are effective to dissociably hybridize to a complementary single-stranded nucleic acid with asymmetric, non-helical base pairing and without oligonucleotide dissociation from the surface of the device. Also, provided are methods for hybridizing solution-state target nucleic acids to probe nucleic acids and for identifying a nucleotide sequence to which a nucleotide-binding protein binds using the biomolecular hybridization devices.

The invention relates to the technical field of fluorescent material, specifically to an activated luminescence material and a method for preparing the same. Different biomolecules are combined to tetraphenyl ethylene through condensation reaction, so the biocompatible activated luminescence material having AIE/AEE features can be obtained. The biomolecules contain water soluble activated luminescence molecules with high fluorescent quantum yield, which have excellent biocompatibility in a solution state and a solid state, and crystalline polymer which can form nanosheets in a water-soluble medium. The obtained activated luminescence material can be applied to living cell fluorescence staining, sensitive explosive detecting and the like.

The invention belongs to the technical field of bio-analytical detection and discloses a fluorescent compound with aggregation-induced luminescence properties and application thereof to the cell fluorescence imaging field. The fluorescent compound with the aggregation-induced luminescence properties adopts one of structures shown as a formula 1 to a formula 4. The fluorescent compound with the aggregation-induced luminescence properties almost does not emit light or emit weak fluorescence in a solution state, can obtain the strong fluorescence emission aggregation-induced luminescence properties in solid state and aggregation states, has room temperature phosphorescent emission properties in a crystalline state, is simple to prepare and wide in luminous spectrum range, is applied to cell fluorescence imaging, biological analysis and other fields, has the characteristics of being sensitive and quick in cell dyeing, small in cytotoxicity, excellent in fluorescence signal anti-photobleaching properties and capable of in-situ real-time monitoring, and has practical application values.

The invention relates to a catalyst sizing agent for preparing a catalytic membrane electrode of a proton exchange membrane fuel cell. The catalyst sizing agent consists of an electric catalyst, proton conductor polymer distilled water and an organic solvent. The catalyst sizing agent is controlled in a colloid state, so that the pore structure of a prepared catalytic layer of a catalytic membrane electrode is improved, and the cell performance is enhanced. The conventional sizing agent for preparing the catalytic membrane electrode is in a solution state, so that the utilization ratio of a prepared electrode catalyst is not high, the porosity of a catalytic layer is very low, and the gas diffusion process is suppressed. In the invention, the composition and adding sequence of organic solvents in the sizing agent are changed. A preparation method of the catalyst sizing agent comprises the following steps of: conditioning a solution-state catalyst sizing agent with isopropanol, ethanol, ethanediol and the like; and dropwise adding the formed sizing agent into butyl acetate under ultrasonic oscillation condition to form a colloid-state catalyst sizing agent.

The invention discloses an aggregation-induced emission type diarylethene fluorescent molecular switch and a preparation method and application thereof. The aggregation-induced emission type diarylethene fluorescent molecular switch is characterized in that an AIE radical is introduced to gain solid or aggregation strong emission capacity; two diarylethene can be used for quickly quenching fluorescence of fluorescent radicals which aggregate in the surrounding under the irradiation of ultraviolet rays or visible light, thus achieving the purpose of high fluorescent switch ratio. According to the light control type AIE-effect fluorescent molecular switch, the limitation that traditional fluorescent chromophore leads to fluorescence quenching is broken; in addition, the fluorescent molecularswitch in solid and aggregation state has the advantages of being high in switch ratio and high in fluorescence quenching efficiency by being compared with the fluorescent molecular switch in solution state; the fluorescent molecular switch is applicable to information storage under solid state and photoelectric devices and has potential application in biosensing and fluorescence imaging.

The invention discloses a preparation method and application of a super-molecular carbon dioxide adsorbent used in solid and liquid states, and belongs to the technical fields of environmental chemistry and new materials. The method comprises the following steps: carrying out heating reaction on organic amine, a macrocyclic compound and a solvent according to a certain weight ratio; filtering insoluble substances or adding an organic solvent so as to enable sediments to be separated out; and washing solids, and drying in vacuum, so as to obtain a super-molecular complex of the organic amine and the macrocyclic compound. The super-molecular complex is used for adsorbing carbon dioxide in a solution state or a solid state; the carbon dioxide can be efficiently dissociated under the heating or acidifying condition; and the regeneration and the cyclic utilization of the adsorbent are achieved. The super-molecular carbon dioxide adsorbent disclosed by the invention is low in cost, simple in preparation flow, easy to recycle and regenerate, and long in circulating service life; the defects that the organic amine is easy to oxide and degrade, and strong in corrosivity are solved; and the super-molecular carbon dioxide adsorbent is relatively stable in property, and convenient to store and transport, can be used at high temperature, and is a carbon dioxide adsorbent with a wide application prospect.

There is disclosed an overlaminating adhesive film comprising a transparent film, an adhesive layer and a release material successively laminated in this order, wherein said release material has a surface contacting with the adhesive layer, said surface having a centerline average surface roughness of 0.5 μm or lower; an adhesive forming said adhesive layer has a pH of 7.2 to 8.5 in a solution state before applied, and is an acrylic emulsion-type adhesive having an average particle size of 200 nm or smaller; and a monomer component used for production of said adhesive includes an alkoxysilane group-containing unsaturated monomer in which each alkoxy group has 1 to 4 carbon atoms, but includes no hydroxy-containing unsaturated monomer. The overlaminating adhesive film of the present invention exhibits a good water resistance and is free from deterioration in its transparency due to lifting or bubbles when laminated on an adherend, and further prevents an ink-jet printed surface over which the adhesive film is laminated, from suffering from ink bleeding even when the printed surface is allowed to stand under humidified conditions.

An enterprise system/process modeling (ESPO) system and method that permits efficient representation of enterprise systems/processes (ESP) and calculation of global solutions to models associated with these ESPs is disclosed. The system/method incorporates an enterprise system/process modeling definition subsystem (ESPD) in which an interconnected processes, resources, constraints, and objectives may be defined to describe a global enterprise system/process model (ESPO). This ESPO describes the enterprise to be modeled and the various boundaries within which enterprise modeling is to take place. This ESPO is translated and transformed into an intermediate indexed format by an enterprise global modeling subsystem (EGMS) for use in generating the coefficients of an equation matrix. The equation matrix is solved for a solution state space conforming to desired enterprise objectives and the results are presented for review by an enterprise model reporting subsystem (FSPR).

This invention relates to a method for storing a naphthol aralkyl type cyanate ester resin solution, which is difficult to precipitate due to long term storage in a solution state, and particularly relates to a method for storing a naphthol aralkyl type cyanate ester resin solution (AB), which comprises: preparing (i) a naphthol aralkyl type cyanate ester resin solution (AB) comprising a naphthol aralkyl type cyanate ester resin (A), a maleimide compound (B) and a solvent, (ii) a naphthol aralkyl type cyanate ester resin solution (AB) comprising a prepolymer of a naphthol aralkyl type cyanate ester resin (A), a maleimide compound (B) and a solvent, or (iii) a naphthol aralkyl type cyanate ester resin solution (AB) comprising a prepolymer of a naphthol aralkyl type cyanate ester resin (A) and a maleimide compound (B), and a solvent, and; storing the resin solution (AB).