The application belongs to the technical field of biological medical materials, and discloses a polydopamine modified modified nano-
graphyne and a preparation method and application thereof. In the method, the polydopamine
coating is combined with the nano-
graphyne for the first time to construct a GDY@PDA composite
system, and the core defects of the blocky
graphyne, such as easy agglomeration, poor water
solubility and insufficient
biocompatibility, are solved. The graphyne-based material is applied to the near-
infrared two-region photothermal regulation of
neural cell calcium influx for the first time, the
calcium ion channel is activated through the local
thermal effect of the material, and precise, remote and reversible
calcium influx regulation is realized; the limitation that the traditional
biocompatibility modification is easy to fall off and difficult to functionalize is broken through, the polydopamine modification makes the material have both photothermal efficiency and
biological safety, and the application of the graphyne in the treatment of neural diseases (such as
neural cell injury repair) is expanded.