Colloidal bismuth tartrate medicine and preparation method and use thereof

A technology of bismuth tartrate and colloid, which is applied in the directions of pharmaceutical formulations, drug combinations, active ingredients of anhydride/acid/halide, etc. It can solve the problems of low product yield, poor drying effect, and failure to obtain fine powder, etc., and achieve product yield. High efficiency, reduced pollution, and small particle size

Active Publication Date: 2009-07-29
山西双雁生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This preparation process may have residues of acid, alkali or ethanol, which is safe for clinical application; the ethanol precipitation method has low product yield and poor drying effect, and cannot obtain fine powder within a certain particle size range.

Method used

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  • Colloidal bismuth tartrate medicine and preparation method and use thereof
  • Colloidal bismuth tartrate medicine and preparation method and use thereof
  • Colloidal bismuth tartrate medicine and preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] Suspend 25g of bismuth oxide in 15ml of warm water, and dissolve 5g of tartaric acid in 8ml of water, add it to the bismuth oxide and fully stir the reaction to dissolve. Put the reaction solution in a microwave reactor, add 5mg of surfactant (polyoxyethylene stearate), 4mg of emulsifier (Pingpingjia), add low methoxy-D-galacturonic acid, react with microwave for 5h, centrifugal spray Dried to obtain microcrystalline fine powder (15-60 μm), after measurement, its sedimentation volume ratio is 100%-98%, and the intrinsic viscosity number [η] is 132ml / g. Fill it into hard capsules and get ready.

Embodiment 2

[0062] Dissolve 2.5g of bismuth oxide in 10ml of hot water with sorbitol, add it into 5g of tartaric acid under stirring, stir to dissolve, put it in a microwave synthesis machine, add 4mg of surfactant (Tween-80), 5mg of emulsifier (COP), add low methoxy-D-galacturonic acid, microwave reaction for 4h, centrifugal spray drying to get microcrystalline fine powder (10-100μm), fill it into hollow capsules, and obtain.

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Abstract

The invention relates to a colloid tartro-bismuthate and a drug preparation, a preparation method and application of the colloid tartro-bismuthate. The colloid tartro-bismuthate consists of tartaric acid, trivalent metal bismuth ion oxide or salt and low methoxyl-D-polygalacturonase; and the colloid tartro-bismuthate is subjected to centrifugal spraying and drying by dissolution, mixing, precipitation and other methods to form microcrystalline fine powdery colloid tartro-bismuthate. The drug has obvious treatment effect on chronic nonspecific ulcerative colitis, irritable bowel syndrome and chronic colonic inflammation, has good treatment effect on chronic atrophic gastritis and other stomach diseases, has small toxicity and side effect and belongs to a safe, nontoxic and effective drug of a gastroenterology department.

Description

Technical field: [0001] The present invention relates to a kind of medicine and its preparation and application, in particular to a kind of colloidal bismuth tartrate and its pharmaceutical preparation, especially a kind of colloidal bismuth tartrate capsule, and their medical application. It belongs to the field of medicinal chemistry and pharmaceutical preparation. Background technique: [0002] Chronic nonspecific ulcerative colitis (ulcera tive colitis) is a nonspecific inflammatory bowel disease, also known as idiopathic ulcerative colitis. The main symptoms of this disease are long-term chronic diarrhea, abdominal pain, abdominal distension, mucus or pus and blood in the stool, tenesmus, etc., in addition to the formation of crypt abscess and the reduction of goblet cells. Inflammatory reaction and erosion can be seen in colonoscopy biopsy , ulcers and other lesions. Chronic colitis (irritable bowel syndrome) refers to a group of symptoms including abdominal pain, ab...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K31/19A61K33/24A61K31/732A61P1/04
Inventor 于学敏
Owner 山西双雁生物科技有限公司
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